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Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation 认领 引用
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作者 Xinyi Zhang Deling Li +6 位作者 Weiting Zeng Yiru Huang Zongyi Zhan Yuning Zhang Qinyuan Hu Lianyan Huang Minbin Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1236-1248,共13页
Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglio... Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglion cells and their axons,leading to axonal transport dysfuntion,subsequently causing secondary damage to anterior or posterior ends of the visual system.Accordingly,recent evidence indicates that glaucoma is a degenerative disease of the central nervous system that causes damage throughout the visual pathway.However,the effects of glaucoma on synaptic plasticity in the primary visual cortex remain unclear.In this study,we established a mouse model of unilateral chronic ocular hypertension by injecting magnetic microbeads into the anterior chamber of one eye.We found that,after 4 weeks of chronic ocular hypertension,the neuronal somas were smaller in the superior colliculus and lateral geniculate body regions of the brain contralateral to the affected eye.This was accompanied by glial cell activation and increased expression of inflammatory factors.After 8 weeks of ocular hypertension,we observed a reduction in the number of excitatory and inhibitory synapses,dendritic spines,and activation of glial cells in the primary visual cortex contralateral to the affected eye.These findings suggest that glaucoma not only directly damages the retina but also induces alterations in synapses and dendritic spines in the primary visual cortex,providing new insights into the pathogenesis of glaucoma. 展开更多
关键词 chronic ocular hypertension dendritic spines glaucoma glial cells neuroinflammation neuron retinal ganglion cells synaptic plasticity visual cortex visual pathway
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Comparison of visual outcomes between bilateral EDOF IOL implantation and combined EDOF and bifocal IOL implantation 认领 引用
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作者 Jia-Yan Fang Jing Jin +4 位作者 Yi-Ling Jiang Fu-Man Yang Ping-Jun Chang Yin-Ying Zhao Yun-E Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第2期266-272,共7页
AIM:To compare the visual outcomes between bilateral implantation of Tecnis ZXR00 extended depth-of-focus(EDOF)intraocular lenses(IOLs)and mixed implantation of Tecnis ZXR00(EDOF)with Tecnis ZMB00(bifocal)IOLs.METHODS... AIM:To compare the visual outcomes between bilateral implantation of Tecnis ZXR00 extended depth-of-focus(EDOF)intraocular lenses(IOLs)and mixed implantation of Tecnis ZXR00(EDOF)with Tecnis ZMB00(bifocal)IOLs.METHODS:This postoperative cross-sectional study enrolled patients who underwent phacoemulsification combined with IOL implantation.Patients were divided into two groups:the bilateral ZXR00 group(ZXR00-only group)and the mixed IOL group(ZXR00+ZMB00 group).Primary outcome measures included uncorrected and corrected distance visual acuity(UDVA,CDVA),uncorrected and distance-corrected near visual acuity(UNVA,DCNVA),uncorrected and distance-corrected intermediate visual acuity(UIVA,DCIVA),and defocus curves.Secondary outcome measures were visual quality,spectacle independence,patient satisfaction,photic phenomena,and stereopsis.RESULTS:A total of 47 patients(94 eyes)were included,with 26 patients(11 males,15 females)in the ZXR00-only group(mean age:62.73±7.24y)and 21 patients(7 males,14 females)in the mixed group(mean age:65.71±9.16y).There was no statistically significant difference in age between the two groups(P=0.218).The mixed group showed significantly better binocular DCNVA compared to the ZXR00-only group(P=0.002).Defocus curve analysis revealed that the mixed group exhibited superior performance at−2.5 to−4.0 D but inferior performance at−0.5 and−1.5 D.Near stereoacuity was significantly poorer in the mixed group(Randot:5.589±0.744 vs 6.240±0.394 ln arcsec;Contour:4.966±0.973 vs 5.740±0.833 ln arcsec;both P<0.01).Both groups achieved high levels of spectacle independence and patient satisfaction,with no significant differences in photic phenomena or questionnaire scores.CONCLUSION:Mixed implantation of EDOF and bifocal IOLs improve near visual acuity but may compromise near stereopsis.This approach provides a viable option for patients prioritizing near vision;however,caution is recommended for individuals requiring fine stereoscopic vision for daily or professional tasks. 展开更多
关键词 extended depth-of-focus intraocular lens bifocal intraocular lens mixed intraocular lens implantation near visual acuity stereopsis visual quality
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Visual Servo-Based Formation Control of Unmanned Surface Vehicles 认领 引用
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作者 Xiang Liu Yueying Wang +1 位作者 Xudong Zhao Zhiguang Feng 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第2期480-482,共3页
Dear Editor,This letter addresses the formation control problem for unmanned surface vehicles(USVs)under GPS-denied environments.A novel visual servo formation control scheme,utilizing a monocular camera on the follow... Dear Editor,This letter addresses the formation control problem for unmanned surface vehicles(USVs)under GPS-denied environments.A novel visual servo formation control scheme,utilizing a monocular camera on the follower to obtain the leader’s global position,is developed,which is also capable of guaranteeing collision avoidance and visibility maintenance(CA&VM)raised by the requirement of actual formation navigation. 展开更多
关键词 visual servo formation control collision avoidance formation navigation unmanned surface vehicles usvs monocular camera unmanned surface vehicles formation control visual servo
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Guidelines for visual cognitive rehabilitation of visual information processing disorders(2025) 认领 引用
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作者 Yi Shao Cong Zhang +6 位作者 Chun-Nan Zhang Expert Workgroup of Guidelines for VisualCognitive Rehabilitation of Visual Information Processing Disorders Ophthalmology&Optometry Branch of China Association for Ethnic Medicine Ophthalmology Committee ofInternational Association of Translational Medicine Ophthalmology Committee of InternationalAssociation of Intelligent Medicine Intelligent Medicine Special Committee of China MedicalEducation Association Chinese Visual Cognition Study Group 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第8期1484-1498,共15页
●Visual information processing(VIP)is essential for perception and cognition.It enables the brain to acquire and integrate visual stimuli into coherent representations.Visual information processing disorder(VIPD)is c... ●Visual information processing(VIP)is essential for perception and cognition.It enables the brain to acquire and integrate visual stimuli into coherent representations.Visual information processing disorder(VIPD)is characterized by impairments in visuospatial ability,visual analysis,and visuomotor integration.These deficits significantly affect daily activities,learning,and occupational performance.The etiology of these disorders is multifaceted,including developmental anomalies,traumatic brain injuries,ocular diseases,and surgical interventions.This condition involves multiple disciplines(ophthalmology,pediatrics,neurology,and rehabilitation),posing significant challenges for clinical diagnosis,treatment,and rehabilitation.Despite the growing international focus on these disorders,there remain considerable deficiencies in their diagnosis and treatment within China.Clinicians often have limited awareness of VIPD.Standardized diagnostic criteria are lacking,and rehabilitation approaches remain inconsistent.Visual abnormalities are often overlooked in pediatrics and neurology.In contrast,ophthalmology is limited in addressing disorders related to neurological dysfunction.In response to these challenges,this guide has been developed,drawing on the experiences of Europe and America and integrating local research and practice.It provides practical and systematic guidance for the diagnosis and management of VIPD.The objective is to enhance diagnostic and therapeutic capabilities,foster interdisciplinary collaboration,and improve patients’visual function and quality of life. 展开更多
关键词 visual information processing disorder visual cognition rehabilitation therapy guidelines
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Retinitis pigmentosa elicits neurodegeneration within the visual pathway in REEP6 knockout mice 认领 引用
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作者 Yin Yang Maoxia Lv +6 位作者 Binbin Qiao Zhengjiang Yang Houbin Zhang Zhengzheng Wu Yang Xia Dezhong Yao Ke Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3863-3869,共7页
While degenerative diseases of the central nervous system are commonly linked to age-related macular degeneration and glaucoma,they have also been infrequently associated with retinitis pigmentosa,a condition defined ... While degenerative diseases of the central nervous system are commonly linked to age-related macular degeneration and glaucoma,they have also been infrequently associated with retinitis pigmentosa,a condition defined by retinal degeneration that can be caused by an isoform of receptor expression enhancing protein 6(REEP6)expressed in rod photoreceptors.In this study,we used REEP6 knockout mice(REEP6-/-)and wild-type mice(REEP6+/+)to examine neurodegenerative pathology within the visual pathways and neural activity in the primary visual cortex(V1)at three specific time points(1,6,and 10 months)during retinitis pigmentosa progression.Microglial activation was observed in both the retina and the primary visual cortex starting at 1 month of age,but no such activation was detected in the lateral geniculate nucleus at any time point.Not only was increased microglial activation observed at 6 and 10 months within the primary visual cortex of REEP6-/-mice,but also coinciding with elevated levels of phosphorylated Tau expression.At 6 and 10 months of age,primary visual cortex neurons in REEP6-/-mice exhibited reduced responses to grating stimuli and increased spontaneous activity compared with neurons in the primary visual cortex of mice in the control group.Our findings show that retinitis pigmentosa induces neurodegenerative pathology within the visual pathway of mice,particularly in the primary visual cortex,suggesting that ocular disease contributes substantially to central nervous system degeneration.It may provide new clues for the selection of treatment opportunities and the development of therapeutic measures for the subsequent treatment of retinitis pigmentosa or even other retinal degenerative diseases. 展开更多
关键词 microglial activation nerve regeneration neurodegeneration phosphorylated Tau photoreceptor degeneration primary visual cortex(V1) REEP6 retinitis pigmentosa rod photoreceptors visual pathway
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From Macro to Micro:Visualizing Scientific Structures with the SDCL-Framework 认领 引用
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作者 Kang Wang Qiwei Liu +2 位作者 Xin Zhang Tingting Yuan Linwei Cui 《Journal of Data and Information Science》 CSCD 2026年第2期165-180,共16页
Purpose:This study aims to propose a scientific structure visualization framework that systematically characterizes the structure of scientific knowledge and analyzes the evolutionary trajectories of disciplinary topi... Purpose:This study aims to propose a scientific structure visualization framework that systematically characterizes the structure of scientific knowledge and analyzes the evolutionary trajectories of disciplinary topics,thereby providing data-driven support for scientific research decision-making.Design/methodology/approach:To effectively identify the macro-and micro-structures of scientific knowledge,this paper proposes an innovative framework-SDCL-Framework,which integrates the SBERT pre-trained model,density contour visualization,and Log-likelihood ratio(LLR)label extraction algorithm.The synergy among these three components supports a scientific structure analysis paradigm that combines semantic depth,structural precision,and algorithmic robustness.Based on Essential Science Indicators(ESI)highly cited papers,the SDCL-Framework is used to construct visual maps of basic research scientific structures at both macro and micro levels.Findings:The SDCL-Framework can reveal the internal micro-features and evolutionary processes within scientific structures,providing more detailed structural and relational information than traditional BERTopic-based results.Research limitations:Since this study uses only ESI Highly Cited Papers as the dataset to demonstrate the feasibility and effectiveness of our visualization framework,the results serve as a methodological demonstration and cannot be used as a definitive guide for policy or resource allocation.Practical implications:By integrating the SBERT model,density contour visualization,and LLR label extraction algorithm,the SDCL-Framework offers an innovative and comprehensive method for analyzing scientific structures.It assists in identifying research trends,optimizing the allocation of research resources,and supporting scientific decision-making.Originality/value:The SDCL-Framework creatively combines multiple techniques,achieving both semantic depth and structural precision.It uncovers the evolution of scientific research from macro and micro perspectives,demonstrating unique value in the analysis of scientific structures. 展开更多
关键词 scientific structure visualization SBERT density contour log-likelihood ratio(LLR) knowledge graph data visualization
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Visual functioning in patients with macular degeneration compared to patients with cataracts 认领 引用
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作者 Reilley M.Knott Nathan Grove +3 位作者 Jennifer L.Patnaik Niranjan Manoharan Anne M.Lynch Karen L.Christopher 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第7期1278-1283,共6页
●AIM:To compare Visual Functioning Questionnaire-25(VFQ)response data in patients with age-related macular degeneration(AMD)to patients with cataracts.●METHODS:In total 415 individuals with early or intermediate AMD... ●AIM:To compare Visual Functioning Questionnaire-25(VFQ)response data in patients with age-related macular degeneration(AMD)to patients with cataracts.●METHODS:In total 415 individuals with early or intermediate AMD and 236 patients with visually significant cataracts who completed the VFQ-25 from a single academic eye center registry between July 2014 and May 2022 were identified.The effect of disease(AMD versus cataract)on VFQ composite score was analyzed using univariate and multivariable linear regression,controlling for age,race/ethnicity,history of transient ischemic attack(TIA)/stroke,and visual acuity.●RESULTS:AMD patients were older than the cataract group(76.0±7.4y vs 73.2±5.9y,P<0.001).There was no difference in sex between groups with both being predominantly female(63%for AMD vs 61%for cataracts,P=0.801).The VFQ composite score was higher in the AMD group(88.8±10.7 vs 82.8±14.5,P<0.001).All vision-related and socio-emotional subscales had significantly higher scores among AMD compared to cataract patients.When adjusted for age,race/ethnicity,history of TIA/stroke,bettereye visual acuity,and worse-eye visual acuity,patients with cataracts had a 3.3-point lower VFQ composite score(95%CI:-5.3 to-1.4,P<0.001)compared to patients with AMD.●CONCLUSION:Patients with early or intermediate AMD report higher visual functioning compared to patients with cataracts in composite score and all VFQ subscale categories in both unadjusted and adjusted analyses. 展开更多
关键词 Visual Functioning Questionnaire agerelated macular degeneration visual acuity cataract surgery
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From unrecognized to incapacitating:Neuro-ergonomic differentiation of spatial disorientation typologies induced by visual illusions for pilot cognitive training and cockpit design 认领 引用
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作者 Xin YUAN Kam KHNG +3 位作者 Qinbiao LI Cho Yin YIU Qinyu ZHOU Yuanyuan BU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第6期498-517,共20页
Spatial Disorientation(SD)causes 15%–22%of general aviation fatalities,rising to 72%with conflicting visual references.Current detection methods fail to distinguish the three SD types:Type 1(unrecognized),Type 2(reco... Spatial Disorientation(SD)causes 15%–22%of general aviation fatalities,rising to 72%with conflicting visual references.Current detection methods fail to distinguish the three SD types:Type 1(unrecognized),Type 2(recognized),and Type 3(incapacitating),nor the effects of visual illusions.This study presents a neuro-ergonomic framework combining 32-channel Electroencephalogram(EEG)and eye-tracking to identify subtype-specific signatures during visual illusions.Sixteen cadet pilots completed simulated flights under adverse weather and inconsistent instrument displays to induce the three SD types.A customized SD-Probe scale was used to label dynamic SD types during flight.The results showed hierarchical neurophysiological changes:pilots without SD had balanced brain activity;Type 1 showed the lowest neural engagement;activation increased from Type 1 to Type 3,with narrowing visual scanning.Types 2 and 3 exhibited enhanced Beta and Gamma activity in prefrontal and occipital regions,reflecting increased cognitive processing during spatial conflicts.Conflicting visual illusions heightened arousal in peripheral brain areas,disrupting spatial awareness and flight parameter cross-checking.This pioneering study monitors SD occurrence and transitions triggered by visual illusions from a neuro-ergonomics perspective,offering insights into targeted pilot training and multimodal SD detection methods. 展开更多
关键词 EEG Eye tracker Neuro-ergonomics patterns Spatial disorientation Visual illusions
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Neuromorphic devices for intelligent visual perception 认领 引用
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作者 Yixin Zhu Xiangjing Wang +4 位作者 Yuqing Hu Xinli Chen Xianhao Le Changjin Wan Qing Wan 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期186-219,共34页
Neuromorphic visual perception,by emulating the efficient information processing mechanisms of biological vision systems and integrating innovations in materials and device architectures,offers novel solutions for art... Neuromorphic visual perception,by emulating the efficient information processing mechanisms of biological vision systems and integrating innovations in materials and device architectures,offers novel solutions for artificial intelligence sensing.For instance,the incorporation of low-dimensional materials(e.g.,quantum dots,carbon nanotubes,and two-dimensional materials)optimizes device optoelectronic properties,while the synergistic design of organic semiconductors and oxide materials balances flexibility with complementary metal-oxide-semiconductor(CMOS)compatibility.Representative neuromorphic devices such as memristors and neuromorphic transistors address traditional vision system bottlenecks via near-sensor and in-sensor architectures in data transmission latency and energy consumption,offering a new paradigm for highly integrated,energy-efficient real-time perception.However,critical challenges—including device non-uniformity caused by material interface defects,system instability induced by memristor conductance drift,and environmental adaptability under complex illumination—remain barriers to scalable applications.This review comprehensively examines neuromorphic visual perception devices from the perspectives of device structure,operational mechanisms,materials,and applications.It explores the pivotal roles of memristors,electrolyte-gated transistors,and other neuromorphic devices in optical signal perception and information processing,with a focus on their implementations in visual perception tasks and future prospects. 展开更多
关键词 neuromorphic visual perception neuromorphic computing memristor transistor
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Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys 认领 引用
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作者 Wenqing Zhu Ye Liu +5 位作者 Xiaoxiao Chen Liling Qian Wei Wang Leilei Zou Yiliang Lu Rui Liu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第3期619-629,共11页
Long-term exposure to monochromatic light during early life has been shown to significantly impact the development of myopia.However,its effect on color processing in the visual cortex remains unclear.In this study,we... Long-term exposure to monochromatic light during early life has been shown to significantly impact the development of myopia.However,its effect on color processing in the visual cortex remains unclear.In this study,we investigated the effects of different lighting conditions on the functional organization of color representation in the visual cortical areas V1,V2,and V4 of rhesus monkeys raised under long-wave and short-wave monochromatic illumination for four years.Using cytochrome oxidase staining and intrinsic signal optical imaging,we found that the sizes,densities,and response strengths of cortical color domains in V1,V2,and V4 were consistent across illumination conditions.In addition,the cortical distances between specific hue response patches did not significantly differ among the groups.These findings suggested that long-term monochromatic illumination does not alter the spatial organization or functional properties of color domains in the visual cortex of rhesus monkeys.This research provides new insights into the resilience of the visual system's chromatic representation despite altered lighting conditions in early life. 展开更多
关键词 Visual cortex Color Monochromatic illumination Intrinsic signal optical imaging Rhesus monkey
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Tear proteomics reveals biomarkers for visual field progression in normal-tension glaucoma 认领 引用
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作者 Le-Wei Tang Hui-Yan Mao +5 位作者 Mei-Min Lin Si Zhu Qiang-Jie Huang De-Fu Chen Wei-He Zhou Yuan-Bo Liang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第1期1-10,共10页
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas... AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress. 展开更多
关键词 normal-tension glaucoma tears proteomics biomarkers visual field progression
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Multifunctional fluorescent Zn-MOF for latent fingerprint visualization,information anti-counterfeiting encryption and turn-on sensing of ciprofloxacin in river water 认领 引用
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作者 Yuying Yuan Yuting Ren +4 位作者 Yunwu Li Luomei Liu Huiyan Ma Suna Wang Jiandong Pang 《Science China Chemistry》 SCIE EI CAS CSCD 2026年第7期3435-3443,共9页
Luminescent metal-organic frameworks(MOFs)with multifunctional capabilities are highly sought after for applications in security,forensics,and environmental monitoring.Herein,a 2D Zn-MOF(LCU-133)was rationally constru... Luminescent metal-organic frameworks(MOFs)with multifunctional capabilities are highly sought after for applications in security,forensics,and environmental monitoring.Herein,a 2D Zn-MOF(LCU-133)was rationally constructed to integrate multiple functions based on intrinsic fluorescence and hostguest interaction.The intrinsic blue emission of LCU-133 enables high-resolution latent fingerprints imaging on multiple substrates,while its structural adaptability facilitates advanced information encryption via UV-responsive QR codes and anti-counterfeiting inks.Furthermore,LCU-133 demonstrates excellent fluorescence enhancement detection of ciprofloxacin(CIP)in river water,achieving low detection limits(LODs)of 0.56 and 0.25μmol/L,respectively,with high selectivity,fast response and strong anti-interference ability.In addition,using a smartphone RGB app to analyze the luminous test strips,a naked eye on-site visual quantification detection CIP is realized.Comprehensive experiments coupled with DFT calculations elucidate a photoinduced electron transfer(PET)-mediated luminescence enhancement mechanism,underscoring the role of host-guest interactions in selective recognition.This work presents a versatile single MOF-based platform that bridges diverse luminescence applications in security,forensics,and environmental sensing. 展开更多
关键词 multifunctional MOFs latent fingerprints visualization information anti-counterfeiting encryption ciprofloxacin detection luminescence enhancement mechanism
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Correction to:Long-Term Monochromatic Light Exposure Does Not Alter Modular Chromatic Representation in the Visual Cortex of Rhesus Monkeys 认领 引用
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作者 Wenqing Zhu Ye Liu +5 位作者 Xiaoxiao Chen Liling Qian Wei Wang Leilei Zou Yiliang Lu Rui Liu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第6期1440-1440,共1页
The original version of this article unfortunately contained an error in the affiliation information of the author Wei Wang.The affiliation“6.University of Chinese Academy of Sciences,Beijing 100049,China”was missin... The original version of this article unfortunately contained an error in the affiliation information of the author Wei Wang.The affiliation“6.University of Chinese Academy of Sciences,Beijing 100049,China”was missing for Wei Wang.The correct affiliations for Wei Wang2,6 are:2Institute of Neuroscience,Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China 6University of Chinese Academy of Sciences,Beijing 100049,China. 展开更多
关键词 rhesus monkeys affiliation correction modular chromatic representation monochromatic light visual cortex long term exposure
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Diquafosol ophthalmic solution on ocular surface parameters in visual display terminal-associated dry eye disease 认领 引用
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作者 Ting-Ting Yang Hong-Yu Duan +7 位作者 Yi-Fan Zhou Bai-Kai Ma Lu Zhao Qian-Qian Lan Jia-Wei Chen Xiao-Yu Wang Kyung Chul Yoon Hong Qi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第4期673-680,共8页
AIM:To evaluate 3%diquafosol ophthalmic solution on ocular surface parameters and the alterations of lipid and muco-aqueous layer in tear film of patients with visual display terminal(VDT)-associated dry eye disease(D... AIM:To evaluate 3%diquafosol ophthalmic solution on ocular surface parameters and the alterations of lipid and muco-aqueous layer in tear film of patients with visual display terminal(VDT)-associated dry eye disease(DED).METHODS:This study included patients with VDTassociated DED.It was a prospective single-arm interventional clinical trial.Patients were provided with 3%diquafosol ophthalmic solution for 3mo and were followed up in 1,2 and 3mo after treatment.Tear breakup time(TBUT),ocular surface staining score,and ocular surface disease index(OSDI)score were ocular surface characteristics.Lipid layer thickness(LLT),tear meniscus height(TMH),and mucin mRNA expression levels(MUC1,MUC4,MUC5AC,MUC16,and MUC20)were used to measure changes in the tear film.The LipiView interferometer was used to measure the partial blink rate(PBR).RESULTS:Sixty-eight eyes of 68 participants(54 females;mean age 25.12±4.10y;mean spherical equivalent-4.35±2.69 D)were enrolled.Compared with the pre-treatment,OSDI scores and TBUT improved significantly at all follow-up time points(all P<0.01),and TMH increased significantly at 1 and 3mo(P<0.01,P<0.001,respectively).Conjunctival lissamine green staining improved only at 2mo(P<0.05),while corneal fluorescein staining showed no significant changes.Overall LLT remained unchanged,but the PBR<1 subgroup exhibited significant LLT elevation at 3mo(P<0.05),unlike the PBR=1 subgroup.Conjunctival mRNA expression of MUC1,MUC5AC,MUC16,and MUC20 was significantly upregulated at 1 and 3mo(all P<0.01),and MUC4 expression increased significantly only at 1mo(P<0.001).CONCLUSION:In patients with VDT-associated DED,3%diquafosol ophthalmic solution dramatically reduced symptoms and enhanced tear film stability by promoting ocular surface muco-aqueous secretion.Patients with better blinking habits(PBR<1)demonstrate greater LLT improvement than those with poorer habits. 展开更多
关键词 dry eye disease visual display terminal diquafosol mucin
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Direct visualization of the dynamic evolution of sulfur cathodes in Li-S batteries via in situ AFM 认领 引用
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作者 Yuan Li Xu-Sheng Zhang +2 位作者 Jian-Xin Tian Shuang-Yan Lang Rui Wen 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期451-455,共5页
Lithium-sulfur(Li-S)batteries with the high theoretical capacity of 1675 mAh/g have attracted attention as next-generation energy storage systems.Understanding the dynamic evolution and reaction mechanisms at the inte... Lithium-sulfur(Li-S)batteries with the high theoretical capacity of 1675 mAh/g have attracted attention as next-generation energy storage systems.Understanding the dynamic evolution and reaction mechanisms at the interface between sulfur cathodes and the electrolyte is crucial to achieve a high reversible capacity of Li-S batteries.However,due to the challenges in probing the complex Li-S redox reaction,the structural and morphological changes from active sulfur to insoluble lithium sulfide(Li2S)under operating conditions remain poorly understood.Here,the behaviors during sulfur dissolution and Li2S deposition/decomposition under realistic conditions were investigated via in situ atomic force microscopy(AFM).Direct visualizations revealed that tightly stacked sulfur particles hinder essential electronic pathways within the cathode.Furthermore constructing a conductive framework promotes more uniform Li2S deposition,which was previously dispersed across the electrode surface,thus accelerating Li2S conversion kinetics during the subsequent charge process.Peak Force tunneling atomic force microscopy(TUNA)measurements effectively elucidated the correlation between nanoscale structural features and electrical conductivity under varying potentials.Real-time observations reveal the dynamic evolution and reaction mechanisms of sulfur cathodes,offering profound insights into the Li-S redox processes and guiding the rational design of advanced cathodes. 展开更多
关键词 Electrochemical atomic force microscopy Interfacial evolution In situ visualization Sulfur cathodes Li-S batteries
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Enhancing the Fluorescence of an Aggregation-Induced Emission-Active Polymorphic System With Remarkable Mechanochromism for Visualizing Microcracks and Stress Distribution in Textiles 认领 引用
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作者 Chunping Ma Yang Wang +12 位作者 Jiyin He Qiankun Guo Baoyu Huang Wenyang Xie Zihui Liu Anqi Xu Zheng Zhao Jinpeng Mo Longfei Fan Bingjia Xu Zhenguo Chi Ben Zhong Tang Tiangang Luan 《Aggregate》 EI CAS CSCD 2026年第4期88-96,共9页
Visualization of microcracks and stress distribution is crucial for material usability and safety assessment,yet effective monitoring technologies remain very limited.In this work,an organic luminogen TPEXD with aggre... Visualization of microcracks and stress distribution is crucial for material usability and safety assessment,yet effective monitoring technologies remain very limited.In this work,an organic luminogen TPEXD with aggregation-induced emission(AIE)properties has been developed by introducing a 3,4,5,6,7,9-hexahydro-1 H-xanthene-1,8(2 H)-dione group onto tetraphenylethylene via a nonconjugated methylene linkage.TPEXD forms two polymorphs:a deep-blue fluorescent crystal SCb with a low photoluminescence quantum yield(ΦPL)of 2.4%and a blue fluorescent crystal SCc with a highΦPL of 22.6%.Notably,SCb exhibits remarkable mechanochromism(MC)properties and force-induced emission enhancement(FIEE)characteristics opposite to classical mechano-responsive AIE materials,with theΦPL increasing to 30.1%under external force.SCb integrates three mechano-responsive properties,including MC,FIEE,and mechanoluminescence(ML).Under pressure increased from 0 to 17.33 GPa,the emission maximum of SCb gradually red-shifts by 106 nm.Inspired by the MC and FIEE properties,the SCb were leveraged for inkless writing,impact indication,visualized monitoring of microcracks,and stress distribution in textiles.This work provides helpful guidance for developing AIE materials with MC and FIEE characteristics and offers a practical approach for the visualized monitoring of microcracks and stress distribution in materials. 展开更多
关键词 aggregation-induced emission mechanochromism force-induced emission enhancement mechanoluminescence visualization of microcracks and stress distribution
A Comparative Analysis of Deep Learning Approaches for Visual Perception Benchmarks in Ship Navigation 认领 引用
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作者 Ruolan Zhang Xingchen Ji +1 位作者 Jinichi Koue Katsutoshi Hirayama 《哈尔滨工程大学学报（英文版）》 CSCD 2026年第2期600-616,共17页
The establishment of a reliable benchmark for evaluating model performance is critical for advancing deep learning(DL),including its application in the recognition of the ship navigation environment.Despite the steady... The establishment of a reliable benchmark for evaluating model performance is critical for advancing deep learning(DL),including its application in the recognition of the ship navigation environment.Despite the steady progress being made in object detection models across various tasks,maritime navigation presents unique challenges,such as long distances,miscellaneous objects,wide perception scales,and local conditions and features of water areas.Therefore,the improvement of DL approaches for this domain remains a significant challenge.Using a widely applicable offshore image dataset from the ship bridge,we evaluated the performance of the state-of-the-art object detection model from three perspectives:average precision,multiscale feature calculation,and intersection-over-union design,and explored the factors that may affect the model performance evaluation benchmark from the perspective of data quality,scale calculation,feature quantification,and object association.Our experiments have demonstrated that,in the context of object detection tasks within complex water surface traffic scenes,comprehensive model performance evaluation benchmarks are essential.Such benchmarks must incorporate multiple dimensions of the model. 展开更多
关键词 Long-range perception Visual navigation Dataset Multiscale detection Vision benchmark
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Visualizing enzyme-induced mineralization in fractures 认领 引用
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作者 Yang Xiao Chang Zhao +3 位作者 Qingyun Fang Xiang He Jian Chu Hanlong Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第5期4023-4033,共11页
Effective sealing of geological fractures is essential for subsurface stability and mitigating environmental risks such as groundwater contamination and inefficient CO₂sequestration.Enzymatically Induced Carbonate Pre... Effective sealing of geological fractures is essential for subsurface stability and mitigating environmental risks such as groundwater contamination and inefficient CO₂sequestration.Enzymatically Induced Carbonate Precipitation(EICP)offers a promising bio-mediated approach due to its ability to fill and seal fractures.However,real-time precipitation patterns and clogging behavior of EICP under varying fracture and flow conditions remain poorly understood.This study employs a transparent fracture model with visualization to systematically investigate the effects of fracture aperture,flow conditions,and surface roughness on EICP-mediated sealing.Results indicate that fractures with narrower apertures promote tortuous finger-like flowpaths,while wider-aperture fractures show more uniform deposition,with fewer but wider preferential flowpaths.An appropriate injection rate around 1 mL/min ensures uniform precipitation and effective clogging,avoiding inlet clogging at lower rates(0.1 mL/min)and flushing effect reducing deposition at higher rates(10 mL/min).Additionally,rough fractures exhibit higher precipitation efficiency and greater permeability reduction,driven by their irregular surface geometry,which creates more deposition sites and complex flow compared to smooth fractures.Image processing reveals that precipitation patterns in rough fractures match closely with aperture distribution,compared to more concentrated deposition in smooth fractures.These findings provide insights for optimizing EICP-mediated fracture sealing,with implications for groundwater protection and geotechnical practices. 展开更多
关键词 Enzymatically Induced Carbonate Precipitation(EICP) Fracture healing Fracture roughness Fracture aperture Visualization method Permeability evolution
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Engineering a γ-glutamyl transpeptidase-activated fluorogenic probe for quantitative visualization and imaging-guided tumor resection 认领 引用
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作者 Meng Zhao Yan Chen +8 位作者 Chenshuo Zhang Jianan Ding Qiulian Mao Yuqi Zhang Yinjia Gao Yongxiang Bai Laiqing Xie Guohua Fan Haibin Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期577-582,共6页
Quantitative visualization of pivotal biomarkers and accurate delineation of tumor lesion boundary are highly significant to assist surgeon precisely resect the tumors and reduce the risk of recurrence.Activatable flu... Quantitative visualization of pivotal biomarkers and accurate delineation of tumor lesion boundary are highly significant to assist surgeon precisely resect the tumors and reduce the risk of recurrence.Activatable fluorescent probes hold great promise for intraoperative guidance of tumor surgery with high signal-to-background ratio(SBR).Here,we report a γ-glutamyl transpeptidase(GGT)-activated fluorogenic probe Indol-Glu for quantitative visualization of GGT and fluorescence-guided tumor resection.The fluorescence of Indol-Glu was initially“off”state but was specifically activated by GGT to produce enhanced near-infrared(NIR)fluorescence(~37-fold at 741 nm).It is also accompanied by the formation of self-assemblies in the tumor microenvironment resulting in prolonged retention in tumor tissues,which was demonstrated to be able to apply for NIR imaging-guided surgical resection of GGT-overexpressed luciferase-transfected hepatocellular carcinoma(HCC/Luc)tumor.More notably,taking advantage of the ratiometric photoacoustic signal(PA690/PA800)characteristic of Indol-Glu under the digestion of GGT,quantitative visual assessment of GGT activities in various tumor models was achieved in living mice.We believe that this research work may offer a powerful tool for precise diagnosis and surgical resection of malignant tumors. 展开更多
关键词 Activatable fluorogenic probe γ-Glutamyl transpeptidase Ratiometric photoacoustic imaging Quantitative visualization NIR imaging-guided surgery
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Prediction of visual recovery after idiopathic macular hole surgery:a triad of tractional mechanics,subfoveal anatomy,and preoperative function 认领 引用
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作者 Li-Na Cheng Song Wang +3 位作者 Hong-Bing Zhang Hong-Song Li Pei Chen Yan-Yan Xue 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第4期742-749,共8页
AIM:To establish and validate a multidimensional predictive model of postoperative visual recovery after idiopathic macular hole(IMH)surgery.METHODS:Retrospective cohort study.Examinations within a three-month period,... AIM:To establish and validate a multidimensional predictive model of postoperative visual recovery after idiopathic macular hole(IMH)surgery.METHODS:Retrospective cohort study.Examinations within a three-month period,both pre-and postoperative,included assessments of best corrected visual acuity(BCVA),intraocular pressure(IOP),and morphological parameters of IMH with optical coherence tomography(OCT).Then,a series of indices were derived,including the IMH index(MHI),diameter hole index(DHI),macular hole closure index(MHCI),hole form factor(HFF),and tractional hole index(THI).Subfoveal anatomical damage(macular hole inferior volume,Vi)was calculated based on the basal diameter(BD),minimum diameter(MD),and height at the narrowest point(HMD)of IMH.Pearson correlation analysis was utilized to discern significant correlations between postoperative BCVA and the multiple indices examined.A subsequent linear correlation analysis was performed.RESULTS:The study involved 51 eyes from 51 patients(mean age 66.90±6.07y)diagnosed with IMH.Preoperative BCVA was 1.22±0.76 logMAR and improved to 0.88±0.38 logMAR after surgery(P<0.001).The correlation analysis results showed significant correlations between postoperative BCVA and preoperative BCVA(P<0.001),BD(P=0.042),MD(P=0.001),MHI(P=0.047),THI(P=0.004),and Vi(P=0.007).The multidimensional model integrating THI,Vi,and preoperative BCVA significantly outperformed traditional predictors(MD,BD,and height)in terms of postoperative visual recovery prediction.THI,reflecting posterior vitreous traction mechanics,independently predicted anatomical reset potential(β=-0.06,P=0.022),while Vi,quantifying subfoveal photoreceptor disruption,was correlated with structural-functional recovery(β=0.01,P=0.046).Preoperative visual acuity served as a critical surrogate for retinal functional reserve(β=0.15,P=0.020).Redundant morphometric parameters(MHI,DHI,MHCI,HFF)were excluded,as their predictive contributions were subsumed by THI/Vi or mediated by preoperative vision.CONCLUSION:The combination of biomechanical traction(THI),subfoveal anatomical damage(Vi),and preoperative BCVA represents a clinically applicable framework for predicting postoperative visual recovery after IMH surgery.This model can be used as a practical tool to guide surgical planning,facilitating the identification of highrisk patients who may benefit from additional techniques(such as an internal limiting membrane flap)while optimizing resource allocation for standard cases. 展开更多
关键词 macular hole surgery visual acuity biomechanical traction optical coherence tomography prediction
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