The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the...The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.展开更多
In response to the growing need for adaptive optimization algorithms capable of handling complex,multimodal,and high-dimensional search spaces,this paper introduces the Structured Random Cycle-guided Algorithm(SRCA).S...In response to the growing need for adaptive optimization algorithms capable of handling complex,multimodal,and high-dimensional search spaces,this paper introduces the Structured Random Cycle-guided Algorithm(SRCA).SRCA is not presented as a fundamentally new optimization paradigm,but rather as an architectural synthesis and a unified adaptive framework for dynamic operator selection.Based on a cycle-structured architecture,directional and stochastic search behaviors are dynamically selected at the individual level.The algorithm orchestrates well-established structured movements with a diverse pool of stochastic exploration strategies,enabling a coherent and adaptive balance between exploration and exploitation throughout the optimization process.Unlike traditional metaheuristics that rely on fixed behavioral roles or static movement schemes,SRCA allows each individual to adapt its search strategy based on real-time population feedback,monitored through convergence and dispersion indicators.The performance of SRCA is quantitatively assessed under strictly identical experimental conditions on a comprehensive set of 23 benchmark functions,including multimodal and high-dimensional problems,as well as on six classical constrained engineering design problems.Numerical results demonstrate competitive convergence reliability and robustness across diverse optimization tasks,confirming the effectiveness of the proposed adaptive cycle-based framework.展开更多
Frequency diverse array multiple-input multiple-output(FDA-MIMO)radar has gained considerable research attention due to its ability to effectively counter active repeater deception jamming in complex electromagnetic e...Frequency diverse array multiple-input multiple-output(FDA-MIMO)radar has gained considerable research attention due to its ability to effectively counter active repeater deception jamming in complex electromagnetic environments.The effectiveness of interference suppression by FDA-MIMO is limited by the inherent range-angle coupling issue in the FDA beampattern.Existing literature primarily focuses on control methods for FDA-MIMO radar beam direction under the assumption of static beampatterns,with insufficient exploration of techniques for managing nonstationary beam directions.To address this gap,this paper initially introduces the FDA-MIMO signal model and the calculation formula for the FDA-MIMO array output using the minimum variance distortionless response(MVDR)beamformer.Building on this,the problem of determining the optimal frequency offset for the FDA is rephrased as a convex optimization problem,which is then resolved using the cuckoo search(CS)algorithm.Simulations confirm the effectiveness of the proposed approach,showing that the frequency offsets obtained through the CS algorithm can create a dot-shaped beam direction at the target location while effectively suppressing interference signals within the mainlobe.展开更多
Amplitude Phase Shift Keying(APSK)is more suitable for the nonlinear channels of Low Earth Orbit(LEO)satellite communication systems compared to Quadrature Amplitude Modulation(QAM).To tackle challenges posed by Direc...Amplitude Phase Shift Keying(APSK)is more suitable for the nonlinear channels of Low Earth Orbit(LEO)satellite communication systems compared to Quadrature Amplitude Modulation(QAM).To tackle challenges posed by Direct Current(DC)interference and high demodulation complexity,we propose an APSK demodulation algorithm based on K-means clustering.Initially,static DC components are calculated and removed from the received APSK signals.Subsequently,the estimated APSK constellation points serve as initial centers for K-means clustering.These centers are refined through the K-means process and act as theoretical APSK constellation points for the Max-Log-MAP demodulation algorithm,effectively eliminating residual DC.We then introduce a low-complexity APSK demodulation algorithm that utilizes the symmetry of constellation points along with the Euclidean distance between DC-eliminated signals and these constellation points to minimize the set of constellation points.Simulation results indicate that for 32-APSK,our proposed demodulation submodule reduces computational complexity to approximately one-third that of the Max-Log-MAP algorithm while improving Bit Error Rate(BER)performance by about 0.23 dB.Furthermore,end-to-end simulation experiments conducted within LEO satellite communication systems demonstrate that our approach not only maintains this complexity advantage but also enhances BER performance by approximately 1.1 dB.展开更多
The Intrusion Detection System(IDS)is a security mechanism developed to observe network traffic and recognize suspicious or malicious activities.Clustering algorithms are often incorporated into IDS;however,convention...The Intrusion Detection System(IDS)is a security mechanism developed to observe network traffic and recognize suspicious or malicious activities.Clustering algorithms are often incorporated into IDS;however,conventional clustering-based methods face notable drawbacks,including poor scalability in handling high-dimensional datasets and a strong dependence of outcomes on initial conditions.To overcome the performance limitations of existing methods,this study proposes a novel quantum-inspired clustering algorithm that relies on a similarity coefficient-based quantum genetic algorithm(SC-QGA)and an improved quantum artificial bee colony algorithm hybrid K-means(IQABC-K).First,the SC-QGA algorithmis constructed based on quantum computing and integrates similarity coefficient theory to strengthen genetic diversity and feature extraction capabilities.For the subsequent clustering phase,the process based on the IQABC-K algorithm is enhanced with the core improvement of adaptive rotation gate and movement exploitation strategies to balance the exploration capabilities of global search and the exploitation capabilities of local search.Simultaneously,the acceleration of convergence toward the global optimum and a reduction in computational complexity are facilitated by means of the global optimum bootstrap strategy and a linear population reduction strategy.Through experimental evaluation with multiple algorithms and diverse performance metrics,the proposed algorithm confirms reliable accuracy on three datasets:KDD CUP99,NSL_KDD,and UNSW_NB15,achieving accuracy of 98.57%,98.81%,and 98.32%,respectively.These results affirm its potential as an effective solution for practical clustering applications.展开更多
Seismic time series forecasting remains challenging due to the nonlinearity,non-stationarity,and noise of earthquake data,and because deep learning models are sensitive to preprocessing and hyperparameter settings.Alt...Seismic time series forecasting remains challenging due to the nonlinearity,non-stationarity,and noise of earthquake data,and because deep learning models are sensitive to preprocessing and hyperparameter settings.Although recent studies have improved neural architectures and optimization techniques,preprocessing is often treated as a fixed or manually designed stage,with limited integration into model optimization.To address this,this paper proposes an integrated,data-driven modelling framework that combines guided preprocessing with systematic hyperparameter optimization for seismic prediction,specifically forecasting earthquake magnitude from seismic catalog time-series data,with experiments conducted on Canadian seismic records.The method uses a Large Language Model to guide data preparation and feature engineering,rather than fully automate them,and applies deep learning-based forecasting with the N-HITS architecture,optimized via metaheuristic-assisted feature selection and hyperparameter tuning.The Football Optimization Algorithm(FbOA),employed as a metaheuristic optimization strategy in this study,is evaluated and compared with several well-known optimizers under identical conditions.The results show significant performance gains,with FbOA achieving superior accuracy,robustness,and convergence compared to baseline and competing methods.Notably,error metrics are reduced(MSE 3.10×10-7,RMSE 5.57×103),with high performance indicators(r=0.982,R2=0.979,NSE=0.981,WI=0.985).These results highlight the value of integrating guided preprocessing with optimization and demonstrate a scalable framework for high-precision time-series prediction in geophysical and related domains.展开更多
OBJECTIVE:To investigate the efficacy and safety of electro-thumbtack needles(ETN)compared with sham acupuncture(SA)on symptoms during high-altitude exposure.METHODS:In this pilot,single-blind,randomized,controlled st...OBJECTIVE:To investigate the efficacy and safety of electro-thumbtack needles(ETN)compared with sham acupuncture(SA)on symptoms during high-altitude exposure.METHODS:In this pilot,single-blind,randomized,controlled study,we assessed the impact of ETN acupuncture on symptoms associated with high-altitude exposure.Participants were randomized into two groups:an ETN group and a SA group.The intervention involved routine skin disinfection and stimulation of seven acupuncture points:bilateral Neiguan(PC6),bilateral Hegu(LI4),bilateral Taiyang(EX-HN5),and Zhongwan(CV12),with pressure for approximately 1 min on each point.The primary outcome was the Lake Louise Score after intervention.Secondary outcome measures were heart rate,blood pressure,blood oxygen saturation,headache visual analogue scale score,clinical function score,and sleep scale scores after the intervention.RESULTS:We enrolled 125 patients with high-altitude exposure;59 in the ETN group and 66 in the SA group.AMS was present in 37.90%of the 125 patients.The Lake Louise Score in the ETN group was significantly lower than that in the SA group 6 h postintervention[P=0.05;adjusted mean difference:0.56;95%confidence interval(CI)(0.01,1.11)].The changes in blood pressure,blood oxygen saturation,and Groningen Sleep Quality Survey,Stanford Sleepiness Scale,visual analog scale,and clinical functioning scores 48 h postintervention showed no significant differences between the groups.Decreases in cerebral oxygen saturation postintervention differed significantly between the ETN and SA groups[P<0.05;t=-1.39;95%CI(3.50,0.59)].CONCLUSIONS:This study assessed the feasibility of ETN to address AMS and was a preliminary evaluation of its efficacy.This study provides a basis for the development of intervention programs and scale implementation.ETN is a possible intervention in AMS for special populations,such as those with drug contraindications or pregnant women.This study may guide future research by presenting novel insights,strategic directions,and foundational evidence.展开更多
Background:Auriculotherapy is a simple,convenient,nonpharmacological option that has shown positive effects for insomnia patients,but its efficacy and safety remain unknown.Objective:The aim of this study is to evalua...Background:Auriculotherapy is a simple,convenient,nonpharmacological option that has shown positive effects for insomnia patients,but its efficacy and safety remain unknown.Objective:The aim of this study is to evaluate the efficacy and safety of auricular therapy for insomnia.Design,setting,participants and intervention:An 18-week(2-week screening,4-week treatment,and 12-week follow-up),recruiter-and assessor-blinded,randomized,sham-controlled trial was performed.Patients were recruited from outpatient settings at three clinical centers in China from 2 February 2023 to 26 January 2024.Participants had insomnia for more than 3 months and met the criteria classified in the Diagnostic and Statistical Manual of Mental Disorders(Fifth Edition).Patients were randomly assigned in a 1:1 ratio to receive auricular therapy(AT)or sham AT(SAT)for 4 consecutive weeks,twice a week,and once every 3 days.Main outcome measures:Primary outcome was the response rate at week 4 after treatment,defined as the percentage of patients with at least a 50%reduction in Pittsburgh Sleep Quality Index(PSQI)from baseline.Secondary outcomes consisted of response rates at other time points,PSQI and 4 related scales,actigraphy-recorded sleep efficiency,sleep arousal frequency,and total sleep time.Results:A total of 234 participants were screened,and 156 patients(122 female[78.2%];mean[standard deviation]age,37.2[13.5]years)were included in the intention-to-treat analysis,with 78 participants randomized to each group.A total of 117 participants(75%)were followed up for 3 months.The AT group had a higher response rate at week 4 than the SAT group(39.73%[29/73]vs 23.29%[17/73],P=0.03),and the response rates for the AT and SAT groups at week 2 were 28.38%(21/74)and 13.33%(10/75),respectively(P=0.02).The differences between the two groups in the PSQI at each time point(P<0.05)and the Insomnia Severity Index at weeks 4 and 12(both P=0.03)were also statistically significant.The other partial outcomes also showed statistically significant differences.Adverse events occurred in 2 cases in the AT group(2.60%).Conclusion:Four-week AT treatment was an effective and safe alternative therapy for insomnia,although the difference with the SAT treatment did not reach the minimal clinically important difference.Adverse events were mild or transient.展开更多
Background:Risk-adapted colorectal cancer(CRC)screening has the potential to balance effectiveness with resource demands,yet evidence comparing it with established methods remains limited.This study aims to compare ou...Background:Risk-adapted colorectal cancer(CRC)screening has the potential to balance effectiveness with resource demands,yet evidence comparing it with established methods remains limited.This study aims to compare outcomes of risk-adapted CRC screening with colonoscopy and fecal immunochemical test(FIT)strategies.Methods:We adopted a hybrid methodology combining real-world data from a population-based CRC screening randomized controlled trial(TARGET-C)with projections from a validated Markov-based microsimulation model(MIMIC-CRC).The TARGET-C trial enrolled 19,582 participants aged 50-74 years from 6 centers in China,randomized in a 1:2:2 ratio into three groups.After applying the exclusion criteria,the final analysis included 3883 participants in the one-time colonoscopy group,7793 in the annual FIT group,and 7697 in the risk-adapted screening group.In the latter group,screening allocation was determined by a composite risk score incorporating age,sex,family history of CRC,smoking status,and body mass index,with high-risk participants referred for colonoscopy and low-risk participants for FIT.The primary outcome was detection rates of advanced neoplasm(CRC and advanced adenoma)over 4 rounds.Secondary outcomes included screening participation,colonoscopy demand,and costs from a societal perspective.Long-term effectiveness and cost-effectiveness were modeled over 15 years using MIMIC-CRC.Results:Across 4 rounds,overall participation rates(attending at least one screening round)were 42.3%(colonoscopy),99.8%(FIT),and 92.5%(risk-adapted).Detection rates of advanced neoplasms were 2.8%,2.3%,and 2.6%,respectively,with no significant differences(P>0.05).Colonoscopies needed to detect 1 advanced neoplasm were 15.4,7.9,and 9.3,respectively.From a societal perspective,the cost for detecting 1 advanced neoplasm was 15,341,21,754,and 24,300 Chinese Yuan,respectively.Over 15 years,risk-adapted screening reduced incidence by 16.7%and mortality by 21.5%compared with no screening,slightly less effective than colonoscopy(24.6%and 24.8%,respectively).Under observed real-world adherence,colonoscopy was the most cost-effective;under perfect full adherence,risk-adapted screening was the most cost-effective.Conclusions:In this population-based CRC screening trial,risk-adapted screening,colonoscopy,and FIT demonstrated comparable effectiveness,but differed in participation rates,resource utilization,and cost-effectiveness.Risk-adapted screening could serve as a complementary approach to established strategies,particularly when health resources are limited.Trial registration:Chinese Clinical Trial Registry(ChiCTR1800015506).展开更多
When milling structural components with varying axial depths and widths,cutting forces tend to fluctuate,negatively impacting tool life and machining accuracy.To mitigate the force fluctuations and enhance tool longev...When milling structural components with varying axial depths and widths,cutting forces tend to fluctuate,negatively impacting tool life and machining accuracy.To mitigate the force fluctuations and enhance tool longevity,developing a simple,reliable,and easy-to-implement force control system for milling is essential,which is an important step toward advancing intelligent manufacturing.This paper explores the use of genetic algorithms(GA) for powerful optimization capabilities in developing self-tuning milling force controllers.A comprehensive framework for optimizing a fuzzy logic controller using an enhanced GA is specifically designed for the milling process.The optimization integrates the GA with a simulation model,fine-tuning membership functions and optimizing fuzzy rule selection.The enhanced GA incorporates the Integral of Time-weighted Absolute Error(ITAE) as the fitness criterion to improve the robustness and responsiveness of the controller.The optimized fuzzy logic controller is implemented within a computer numerical control system,adjusting feed rates in real-time to control milling forces.The performance of the proposed controller is validated through step and slope milling tests,demonstrating an average control accuracy of 95.52%.Comparative evaluations with other controllers show that the proposed system offers a significant improvement,achieving up to 4.58% better control accuracy in step milling tests.展开更多
OBJECTIVE:To observe the clinical efficacy and safety of Chinese herbal medicine Jiawei Simiao Yongan granules(加味四妙勇安颗粒,JWSMYAG)in the treatment of non-infectious anterior uveitis(NIAU).METHODS:We conducted a ...OBJECTIVE:To observe the clinical efficacy and safety of Chinese herbal medicine Jiawei Simiao Yongan granules(加味四妙勇安颗粒,JWSMYAG)in the treatment of non-infectious anterior uveitis(NIAU).METHODS:We conducted a single-center,randomized,open-labeled clinical trial in adults with NIAU.Patients received standard treatment or a combination of JWSMYAG(twice daily)for three months,with a 3-month withdrawal period for observation.The primary endpoint was the recurrence rate within six months.RESULTS:A total of 98 patients were included in the intention-to-treat analysis,including 49 patients in the Traditional Chinese Medicine(TCM)group and 49 patients in the control group.Compared with the control group,the number of relapses was significantly lower in the TCM group[24.5%vs 6.1%,P=0.0224;Hazard Ratio=0.208,95%Confidence Interval(0.059,0.737)];in addition,patients in the TCM group had lower symptom scores of eye pain,insomnia,and bitter taste within two weeks(all P10 mm Hg,the scoring of anterior chamber cells,the number of patients with keratic precipitates(+)after 1/2 weeks of treatment,and the scores of conjunctival hyperemia,headache,photophobia,and lacrimation.The difference in the number of adverse events between the two groups over six months was not statistically significant.CONCLUSION:JWSMYAG can reduce the recurrence rate of NIAU,alleviate ocular pain,insomnia,and bitter taste symptoms in patients with NIAU,and have a favorable safety profile.展开更多
Few-for-many(F4M)optimization,recently introduced as a novel paradigm in multi-objective optimization,aims to find a small set of solutions that effectively handle a large number of conflicting objectives.Unlike tradi...Few-for-many(F4M)optimization,recently introduced as a novel paradigm in multi-objective optimization,aims to find a small set of solutions that effectively handle a large number of conflicting objectives.Unlike traditional many-objective optimization methods,which typically attempt comprehensive coverage of the Pareto front,F4M optimization emphasizes finding a small representative solution set to efficiently address highdimensional objective spaces.Motivated by the computational complexity and practical relevance of F4M optimization,this paper proposes a new evolutionary algorithm explicitly tailored for efficiently solving F4M optimization problems.Inspired by Smetric selection evolutionary multi-objective optimization algorithm(SMS-EMOA),our proposed approach employs a(μ+1)-evolution strategy guided by the objective of F4M optimization.Furthermore,to facilitate rigorous performance assessment,we propose a novel benchmark test suite specifically designed for F4M optimization by leveraging the similarity betw een the R2indicator and F4M formulations.Our test suite is highly flexible,allowing any existing multi-objective optimization problem to be transformed into a corresponding F4M instance via scalarization using the weighted Tchebycheff function.Comprehensive experimental evaluations on benchmarks demonstrate the superior performance of our algorithm compared to existing state-of-the-art algorithms,especially on instances involving a large number of objectives.The source code of the proposed algorithm will be released publicly.Source code is available at http://gffzz188fe103f8f1460asnxcv9bw0c0qc6owp.ffgz.tsg.suse.edu.cn/MOL-SZU/SoM-EMOA.展开更多
Objective:Conventional total hip arthroplasty(cTHA)may be technically challenging in some scenarios.Robotic-assisted THA(rTHA)was introduced in the 1980s with an active ROBODOC system.Considering the miscellaneous dra...Objective:Conventional total hip arthroplasty(cTHA)may be technically challenging in some scenarios.Robotic-assisted THA(rTHA)was introduced in the 1980s with an active ROBODOC system.Considering the miscellaneous drawbacks of this early system,more recent semi-active systems were subsequently introduced.The present meta-analysis aimed to compare the operative and clinical outcomes of rTHA assisted by semi-active systems with those of cTHA in randomized controlled trials(RCTs).Methods:The present study was conducted in line with the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 expanded statement.Three databases were searched for relevant studies(July 2025)in English,including PubMed,Web of Science Core Collection and Scopus.The outcome data included the operative time,amount of intraoperative and total blood loss,duration of hospital stay,number of patients in the Lewinnek or Callanan safe zones,postoperative Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,postoperative Harris hip score and leg length discrepancy(LLD).The risk of bias in the included studies was assessed via the risk of bias assessment tool.Results:Eleven RCTs with 834 patients were included in this study.No significantdifferences were found between rTHA and cTHA regarding blood loss,hospital stay,WOMAC score or Harris hip score.While cTHA had a significantlyshorter operative duration(MD:22.12;95%CI:9.75,34.48),rTHA was associated with a significantlygreater frequency of patients in the Lewinnek(OR:4.11;95%CI:2.04,8.31)and Callanan(OR:3.93;95%CI:1.15,13.57)safe zones and a significantly lower LLD(SMD:-0.45;95%CI:-0.60,-0.30).Conclusion:Compared with cTHA,rTHA is a more accurate surgical technique with comparable blood loss,hospital stay and clinical scores.展开更多
Accurate prediction of flood events is important for flood control and risk management.Machine learning techniques contributed greatly to advances in flood predictions,and existing studies mainly focused on predicting...Accurate prediction of flood events is important for flood control and risk management.Machine learning techniques contributed greatly to advances in flood predictions,and existing studies mainly focused on predicting flood resource variables using single or hybrid machine learning techniques.However,class-based flood predictions have rarely been investigated,which can aid in quickly diagnosing comprehensive flood characteristics and proposing targeted management strategies.This study proposed a prediction approach of flood regime metrics and event classes coupling machine learning algorithms with clustering-deduced membership degrees.Five algorithms were adopted for this exploration.Results showed that the class membership degrees accurately determined event classes with class hit rates up to 100%,compared with the four classes clustered from nine regime metrics.The nonlinear algorithms(Multiple Linear Regression,Random Forest,and least squares-Support Vector Machine)outperformed the linear techniques(Multiple Linear Regression and Stepwise Regression)in predicting flood regime metrics.The proposed approach well predicted flood event classes with average class hit rates of 66.0%-85.4%and 47.2%-76.0%in calibration and validation periods,respectively,particularly for the slow and late flood events.The predictive capability of the proposed prediction approach for flood regime metrics and classes was considerably stronger than that of hydrological modeling approach.展开更多
Single-photon avalanche diode(SPAD)image sensors are widely used in direct time-of-flight(D-TOF)imaging,but their ranging performance is often constrained by limited laser power.This article presents a SPAD-based D-TO...Single-photon avalanche diode(SPAD)image sensors are widely used in direct time-of-flight(D-TOF)imaging,but their ranging performance is often constrained by limited laser power.This article presents a SPAD-based D-TOF imaging system that combines a reconfigurable macro-pixel sensor architecture with a lightweight depth completion algorithm to achieve long-range depth imaging with enhanced spatial resolution under low optical power.The proposed sensor adopts a back-side illuminated(BSI)3D-stacked architecture with programmable macro-pixels that enhance detection sensitivity and enable flexible sensitivity–resolution trade-offs.An injection-locked ring-oscillator-based time-to-digital converter(RO-TDC)array achieves a time resolution of 152.5 ps,enabling accurate TOF measurement at an optical power of 10 mW.To compensate for macropixel-induced resolution loss,a probabilistic normalized convolutional neural network(pNCNN)is employed for depth completion using sparse depth inputs only.Experimental results demonstrate that up to 30×effective resolution enhancement of the system can be achieved via the depth completion algorithm without changing the physical resolution of the sensor.Additionally,the proposed system achieves a maximum ranging distance of 90 m and a range-to-power figure-of-merit(FOM)of9 m/mW,which validates the effectiveness of the system.展开更多
The Marine Predators Algorithm(MPA),while promising for complex optimization,suffers from limited solution precision,imbalanced exploration–exploitation,and premature convergence.To address these shortcomings,this pa...The Marine Predators Algorithm(MPA),while promising for complex optimization,suffers from limited solution precision,imbalanced exploration–exploitation,and premature convergence.To address these shortcomings,this paper proposes a phased-enhancement variant named PEMPA,which integrates three novel strategies into distinct phases of MPA:1)embedding historical best positions in the high-velocity ratio phase to refine solution quality;2)introducing an adaptive inertia weight based on an inverted Sigmoid function in the unit-velocity ratio phase to systematically balance exploration and exploitation;and 3)designing a two-stage opposition-based learning operator in the low-velocity ratio phase to prevent premature convergence.The performance of PEMPA is comprehensively evaluated across 23 classical benchmark functions,the IEEE Congress on Evolutionary Computation(CEC)2017 test suite,21 feature selection tasks,and a real-world medical insurance fraud detection problem.Experimental results confirm that the proposed strategies significantly enhance the efficiency and robustness of MPA.Furthermore,PEMPA demonstrates highly competitive performance compared with several state-of-the-art metaheuristic algorithms,validating its effectiveness and scalability for diverse optimization challenges.展开更多
Constitutive modeling for geomaterials remains challenging because of limited data availability,strong nonlinearity,pressure sensitivity,and the non-smooth characteristics of commonly used yield surfaces.This study pr...Constitutive modeling for geomaterials remains challenging because of limited data availability,strong nonlinearity,pressure sensitivity,and the non-smooth characteristics of commonly used yield surfaces.This study presents a deep-learning-based constitutive method for geomaterials that incorporates a neural stress-integration procedure based on the cutting plane algorithm(CPA).Two compact fully connected networks are trained to learn the yield function and its stress gradient from an augmented stress-state dataset.The trained networks are then incorporated into a cutting plane return-mapping procedure,in which only first-order information is required for the plastic stress return.This avoids explicit analytical yield expressions and second-derivative evaluations and is therefore more naturally compatible with non-smooth Mohr-Coulomb-type yield-surface representations in a first-order returnmapping sense.Numerical results show that the proposed method reproduces the reference Mohr-Coulomb response along the examined monotonic triaxial compression paths.Compared with the finite-difference closest-point projection method(CPPM)implementation considered in this study,the CPA-based neural stress-update procedure requires fewer network calls per update,indicating a more economical implementation for the present learned constitutive framework.展开更多
The rapid growth of Internet of Things(IoT)and 5G technologies has led to a sharp increase in computing demands from wireless devices,making efficient task offloading a critical challenge.Key issues include reducing a...The rapid growth of Internet of Things(IoT)and 5G technologies has led to a sharp increase in computing demands from wireless devices,making efficient task offloading a critical challenge.Key issues include reducing application latency,lowering the energy consumption of terminal devices,and improving overall system performance,all of which directly affect user experience.Traditional genetic algorithms(GA),inspired by biological evolution,have been widely used in task offloading,but they often suffer from slow convergence and a tendency to fall into local optima in complex scenarios,limiting their effectiveness.To address these drawbacks,this paper proposes a task offloading strategy based on a refined elite mechanism in a GA.The algorithm introduces multi-point variation in both crossover and mutation operations to enhance population diversity,avoid local optima,and accelerate convergence.This design leverages the GA’s strength in multi-objective optimization,which outperforms other bionic heuristic algorithms that excel in single domains.Comparative experiments with GA,ant colony optimization,Deep Q-Network,Greedy algorithms,simulated annealing algorithm and particle swarm optimization,show that the proposed algorithm improves convergence speed by 35%,reduces task completion time by 6%,and optimizes energy consumption by approximately 18%.展开更多
Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT*),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narr...Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT*),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narrow passages,slow convergence,and high computational costs.To address these challenges,this paper proposes a novel hybrid global path planning algorithm integrating Gaussian sampling and quadtree optimization(RRT*-GSQ).This methodology aims to enhance path planning by synergistically combining a Gaussian mixture sampling strategy to improve node generation in critical regions,an adaptive step-size and direction optimization mechanism for enhanced obstacle avoidance,a Quadtree-AABB collision detection framework to lower computational complexity,and a dynamic iteration control strategy for more efficient convergence.In obstacle-free and obstructed scenarios,compared with the conventional RRT*,the proposed algorithm reduced the number of node evaluations by 67.57%and 62.72%,and decreased the search time by 79.72%and 78.52%,respectively.In path tracking tests,the proposed algorithm achieved substantial reductions in RMSE of the final path compared to the conventional RRT*.Specifically,the lateral RMSE was reduced by 41.5%in obstacle-free environments and 59.3%in obstructed environments,while the longitudinal RMSE was reduced by 57.2%and 58.5%,respectively.Furthermore,the maximum absolute errors in both lateral and longitudinal directions were constrained within 0.75 m.Field validation experiments in an operational orchard confirmed the algorithm's practical effectiveness,showing reductions in the mean tracking error of 47.6%(obstacle-free)and 58.3%(with obstructed),alongside a 5.1%and 7.2%shortening of the path length compared to the baseline method.The proposed algorithm effectively enhances path planning efficiency and navigation accuracy for robots,presenting a superior solution for high-precision autonomous navigation of agricultural robots in orchard environments and holding significant value for engineering applications.展开更多
Background:The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated.While primary debulking surgery(PDS)has been considered the standard approach,recent randomized trial...Background:The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated.While primary debulking surgery(PDS)has been considered the standard approach,recent randomized trials have questioned its survival advantage over neoadjuvant chemotherapy(NACT)followed by interval debulking surgery(IDS).The study aimed to systematically evaluate phase Ⅲ randomized controlled trials comparing PDS and NACT.Methods:Following PRISMA guidelines(PROSPERO ID 1169057),PubMed and Scopus were systematically searched in October 2025 for phase Ⅲ randomized clinical trials evaluating cytoreductive strategies in ovarian carcinoma.Only full-text English studies reporting overall survival(OS)or disease-free survival(DFS)were included.Risk ratios(RR)with 95%confidence intervals(CI)were calculated.Results:Five phase Ⅲ trials(EORTC 55971,CHORUS,JCOG0602,SCORPION,TRUST)comprising 2296 patients met the inclusion criteria.PDS(n=1139)and NACT(n=1157)showed comparable OS(RR 0.99,95%CI 0.94-1.03,p=0.55,I2=0%)and DFS(PDS RR 0.98,95%CI 0.95-1.02,p=0.27,I2=0%).Subgroup analyses confirmed the absence of significant differences for patients with CC0(RR 0.96,95%CI 0.87-1.05,p=0.35,I2=0%),FIGO stage Ⅲ disease(RR 0.97,95%CI 0.92-1.03,p=0.34,I2=0%),or age under 70 years(RR 1.03,95%CI 0.97-1.09,p=0.38,I2=0%).Conclusions:PDS and NACT provide no significant survival outcomes in advanced ovarian cancer.No clear survival benefit for PDS was observed.Refinement of patient selection,integration of predictive biomarkers,and re-evaluation of PDS in the context of HIPEC and Poly-ADP-Ribose Polymerase(PARP)inhibitor use are warranted to guide individualized treatment strategies.展开更多
基金Projects(52374138,51764013)supported by the National Natural Science Foundation of ChinaProject(20204BCJ22005)supported by the Training Plan for Academic and Technical Leaders of Major Disciplines of Jiangxi Province,China+1 种基金Project(2019M652277)supported by the China Postdoctoral Science FoundationProject(20192ACBL21014)supported by the Natural Science Youth Foundation Key Projects of Jiangxi Province,China。
摘要The cemented tailings backfill(CTB)with initial defects is more prone to destabilization damage under the influence of various unfavorable factors during the mining process.In order to investigate its influence on the stability of underground mining engineering,this paper simulates the generation of different degrees of initial defects inside the CTB by adding different contents of air-entraining agent(AEA),investigates the acoustic emission RA/AF eigenvalues of CTB with different contents of AEA under uniaxial compression,and adopts various denoising algorithms(e.g.,moving average smoothing,median filtering,and outlier detection)to improve the accuracy of the data.The variance and autocorrelation coefficients of RA/AF parameters were analyzed in conjunction with the critical slowing down(CSD)theory.The results show that the acoustic emission RA/AF values can be used to characterize the progressive damage evolution of CTB.The denoising algorithm processed the AE signals to reduce the effects of extraneous noise and anomalous spikes.Changes in the variance curves provide clear precursor information,while abrupt changes in the autocorrelation coefficient can be used as an auxiliary localization warning signal.The phenomenon of dramatic increase in the variance and autocorrelation coefficient curves during the compression-tightening stage,which is influenced by the initial defects,can lead to false warnings.As the initial defects of the CTB increase,its instability precursor time and instability time are prolonged,the peak stress decreases,and the time difference between the CTB and the instability damage is smaller.The results provide a new method for real-time monitoring and early warning of CTB instability damage.
摘要In response to the growing need for adaptive optimization algorithms capable of handling complex,multimodal,and high-dimensional search spaces,this paper introduces the Structured Random Cycle-guided Algorithm(SRCA).SRCA is not presented as a fundamentally new optimization paradigm,but rather as an architectural synthesis and a unified adaptive framework for dynamic operator selection.Based on a cycle-structured architecture,directional and stochastic search behaviors are dynamically selected at the individual level.The algorithm orchestrates well-established structured movements with a diverse pool of stochastic exploration strategies,enabling a coherent and adaptive balance between exploration and exploitation throughout the optimization process.Unlike traditional metaheuristics that rely on fixed behavioral roles or static movement schemes,SRCA allows each individual to adapt its search strategy based on real-time population feedback,monitored through convergence and dispersion indicators.The performance of SRCA is quantitatively assessed under strictly identical experimental conditions on a comprehensive set of 23 benchmark functions,including multimodal and high-dimensional problems,as well as on six classical constrained engineering design problems.Numerical results demonstrate competitive convergence reliability and robustness across diverse optimization tasks,confirming the effectiveness of the proposed adaptive cycle-based framework.
基金supported by the National Natural Science Foundation of China(61503408)。
摘要Frequency diverse array multiple-input multiple-output(FDA-MIMO)radar has gained considerable research attention due to its ability to effectively counter active repeater deception jamming in complex electromagnetic environments.The effectiveness of interference suppression by FDA-MIMO is limited by the inherent range-angle coupling issue in the FDA beampattern.Existing literature primarily focuses on control methods for FDA-MIMO radar beam direction under the assumption of static beampatterns,with insufficient exploration of techniques for managing nonstationary beam directions.To address this gap,this paper initially introduces the FDA-MIMO signal model and the calculation formula for the FDA-MIMO array output using the minimum variance distortionless response(MVDR)beamformer.Building on this,the problem of determining the optimal frequency offset for the FDA is rephrased as a convex optimization problem,which is then resolved using the cuckoo search(CS)algorithm.Simulations confirm the effectiveness of the proposed approach,showing that the frequency offsets obtained through the CS algorithm can create a dot-shaped beam direction at the target location while effectively suppressing interference signals within the mainlobe.
基金the Key Project of the Chongqing Natural Science Foundation(2022NSCQ-LZX0191)the Key Research Program of Science and Technology of the Chongqing Education Commission(KJZD-K202202402)+1 种基金the Scientific Research Start-up Fund of Chongqing University of Posts and Telecommunications(A2023-62)the Chongqing Natural Science Foundation(cstc2024ycjh-bgzxm003)for their invaluable support in this research。
摘要Amplitude Phase Shift Keying(APSK)is more suitable for the nonlinear channels of Low Earth Orbit(LEO)satellite communication systems compared to Quadrature Amplitude Modulation(QAM).To tackle challenges posed by Direct Current(DC)interference and high demodulation complexity,we propose an APSK demodulation algorithm based on K-means clustering.Initially,static DC components are calculated and removed from the received APSK signals.Subsequently,the estimated APSK constellation points serve as initial centers for K-means clustering.These centers are refined through the K-means process and act as theoretical APSK constellation points for the Max-Log-MAP demodulation algorithm,effectively eliminating residual DC.We then introduce a low-complexity APSK demodulation algorithm that utilizes the symmetry of constellation points along with the Euclidean distance between DC-eliminated signals and these constellation points to minimize the set of constellation points.Simulation results indicate that for 32-APSK,our proposed demodulation submodule reduces computational complexity to approximately one-third that of the Max-Log-MAP algorithm while improving Bit Error Rate(BER)performance by about 0.23 dB.Furthermore,end-to-end simulation experiments conducted within LEO satellite communication systems demonstrate that our approach not only maintains this complexity advantage but also enhances BER performance by approximately 1.1 dB.
基金supported by the NSFC(Grant Nos.62176273,62271070,62441212)The Open Foundation of State Key Laboratory of Networking and Switching Technology(Beijing University of Posts and Telecommunications)under Grant SKLNST-2024-1-062025Major Project of the Natural Science Foundation of Inner Mongolia(2025ZD008).
摘要The Intrusion Detection System(IDS)is a security mechanism developed to observe network traffic and recognize suspicious or malicious activities.Clustering algorithms are often incorporated into IDS;however,conventional clustering-based methods face notable drawbacks,including poor scalability in handling high-dimensional datasets and a strong dependence of outcomes on initial conditions.To overcome the performance limitations of existing methods,this study proposes a novel quantum-inspired clustering algorithm that relies on a similarity coefficient-based quantum genetic algorithm(SC-QGA)and an improved quantum artificial bee colony algorithm hybrid K-means(IQABC-K).First,the SC-QGA algorithmis constructed based on quantum computing and integrates similarity coefficient theory to strengthen genetic diversity and feature extraction capabilities.For the subsequent clustering phase,the process based on the IQABC-K algorithm is enhanced with the core improvement of adaptive rotation gate and movement exploitation strategies to balance the exploration capabilities of global search and the exploitation capabilities of local search.Simultaneously,the acceleration of convergence toward the global optimum and a reduction in computational complexity are facilitated by means of the global optimum bootstrap strategy and a linear population reduction strategy.Through experimental evaluation with multiple algorithms and diverse performance metrics,the proposed algorithm confirms reliable accuracy on three datasets:KDD CUP99,NSL_KDD,and UNSW_NB15,achieving accuracy of 98.57%,98.81%,and 98.32%,respectively.These results affirm its potential as an effective solution for practical clustering applications.
摘要Seismic time series forecasting remains challenging due to the nonlinearity,non-stationarity,and noise of earthquake data,and because deep learning models are sensitive to preprocessing and hyperparameter settings.Although recent studies have improved neural architectures and optimization techniques,preprocessing is often treated as a fixed or manually designed stage,with limited integration into model optimization.To address this,this paper proposes an integrated,data-driven modelling framework that combines guided preprocessing with systematic hyperparameter optimization for seismic prediction,specifically forecasting earthquake magnitude from seismic catalog time-series data,with experiments conducted on Canadian seismic records.The method uses a Large Language Model to guide data preparation and feature engineering,rather than fully automate them,and applies deep learning-based forecasting with the N-HITS architecture,optimized via metaheuristic-assisted feature selection and hyperparameter tuning.The Football Optimization Algorithm(FbOA),employed as a metaheuristic optimization strategy in this study,is evaluated and compared with several well-known optimizers under identical conditions.The results show significant performance gains,with FbOA achieving superior accuracy,robustness,and convergence compared to baseline and competing methods.Notably,error metrics are reduced(MSE 3.10×10-7,RMSE 5.57×103),with high performance indicators(r=0.982,R2=0.979,NSE=0.981,WI=0.985).These results highlight the value of integrating guided preprocessing with optimization and demonstrate a scalable framework for high-precision time-series prediction in geophysical and related domains.
基金the Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences:Registration and Enrollment Study on the Evaluation of the Efficacy of Traditional Chinese Medicine in the Real World(No.CI2021A05408)Standard Project of Chinese Acupuncture Society:Expert Consensus on Acupuncture and Moxibustion Treatment for High Altitude Sickness(No.Z0674,surplus funds)+1 种基金Project of China Academy of Chinese Medical Sciences:Research on the Key Technology of the Real-World Case Registry(No.2022031)Project of the National Key Research and Development Program:Development of International Clinical Research Service Standard for Acupuncture and Moxibustion(No.2019YFC1712205)。
摘要OBJECTIVE:To investigate the efficacy and safety of electro-thumbtack needles(ETN)compared with sham acupuncture(SA)on symptoms during high-altitude exposure.METHODS:In this pilot,single-blind,randomized,controlled study,we assessed the impact of ETN acupuncture on symptoms associated with high-altitude exposure.Participants were randomized into two groups:an ETN group and a SA group.The intervention involved routine skin disinfection and stimulation of seven acupuncture points:bilateral Neiguan(PC6),bilateral Hegu(LI4),bilateral Taiyang(EX-HN5),and Zhongwan(CV12),with pressure for approximately 1 min on each point.The primary outcome was the Lake Louise Score after intervention.Secondary outcome measures were heart rate,blood pressure,blood oxygen saturation,headache visual analogue scale score,clinical function score,and sleep scale scores after the intervention.RESULTS:We enrolled 125 patients with high-altitude exposure;59 in the ETN group and 66 in the SA group.AMS was present in 37.90%of the 125 patients.The Lake Louise Score in the ETN group was significantly lower than that in the SA group 6 h postintervention[P=0.05;adjusted mean difference:0.56;95%confidence interval(CI)(0.01,1.11)].The changes in blood pressure,blood oxygen saturation,and Groningen Sleep Quality Survey,Stanford Sleepiness Scale,visual analog scale,and clinical functioning scores 48 h postintervention showed no significant differences between the groups.Decreases in cerebral oxygen saturation postintervention differed significantly between the ETN and SA groups[P<0.05;t=-1.39;95%CI(3.50,0.59)].CONCLUSIONS:This study assessed the feasibility of ETN to address AMS and was a preliminary evaluation of its efficacy.This study provides a basis for the development of intervention programs and scale implementation.ETN is a possible intervention in AMS for special populations,such as those with drug contraindications or pregnant women.This study may guide future research by presenting novel insights,strategic directions,and foundational evidence.
基金funded by grant(No.2022YFC3500601)from the National Key R&D Program of China。
摘要Background:Auriculotherapy is a simple,convenient,nonpharmacological option that has shown positive effects for insomnia patients,but its efficacy and safety remain unknown.Objective:The aim of this study is to evaluate the efficacy and safety of auricular therapy for insomnia.Design,setting,participants and intervention:An 18-week(2-week screening,4-week treatment,and 12-week follow-up),recruiter-and assessor-blinded,randomized,sham-controlled trial was performed.Patients were recruited from outpatient settings at three clinical centers in China from 2 February 2023 to 26 January 2024.Participants had insomnia for more than 3 months and met the criteria classified in the Diagnostic and Statistical Manual of Mental Disorders(Fifth Edition).Patients were randomly assigned in a 1:1 ratio to receive auricular therapy(AT)or sham AT(SAT)for 4 consecutive weeks,twice a week,and once every 3 days.Main outcome measures:Primary outcome was the response rate at week 4 after treatment,defined as the percentage of patients with at least a 50%reduction in Pittsburgh Sleep Quality Index(PSQI)from baseline.Secondary outcomes consisted of response rates at other time points,PSQI and 4 related scales,actigraphy-recorded sleep efficiency,sleep arousal frequency,and total sleep time.Results:A total of 234 participants were screened,and 156 patients(122 female[78.2%];mean[standard deviation]age,37.2[13.5]years)were included in the intention-to-treat analysis,with 78 participants randomized to each group.A total of 117 participants(75%)were followed up for 3 months.The AT group had a higher response rate at week 4 than the SAT group(39.73%[29/73]vs 23.29%[17/73],P=0.03),and the response rates for the AT and SAT groups at week 2 were 28.38%(21/74)and 13.33%(10/75),respectively(P=0.02).The differences between the two groups in the PSQI at each time point(P<0.05)and the Insomnia Severity Index at weeks 4 and 12(both P=0.03)were also statistically significant.The other partial outcomes also showed statistically significant differences.Adverse events occurred in 2 cases in the AT group(2.60%).Conclusion:Four-week AT treatment was an effective and safe alternative therapy for insomnia,although the difference with the SAT treatment did not reach the minimal clinically important difference.Adverse events were mild or transient.
基金supported by the Chinese Academy of Medical Science Innovation Fund for Medical Science(2022-I2M-1-003)the National Natural Science Foundation of China(82173606,82273726)the Beijing Nova Program of Science and Technology(20230484397).
摘要Background:Risk-adapted colorectal cancer(CRC)screening has the potential to balance effectiveness with resource demands,yet evidence comparing it with established methods remains limited.This study aims to compare outcomes of risk-adapted CRC screening with colonoscopy and fecal immunochemical test(FIT)strategies.Methods:We adopted a hybrid methodology combining real-world data from a population-based CRC screening randomized controlled trial(TARGET-C)with projections from a validated Markov-based microsimulation model(MIMIC-CRC).The TARGET-C trial enrolled 19,582 participants aged 50-74 years from 6 centers in China,randomized in a 1:2:2 ratio into three groups.After applying the exclusion criteria,the final analysis included 3883 participants in the one-time colonoscopy group,7793 in the annual FIT group,and 7697 in the risk-adapted screening group.In the latter group,screening allocation was determined by a composite risk score incorporating age,sex,family history of CRC,smoking status,and body mass index,with high-risk participants referred for colonoscopy and low-risk participants for FIT.The primary outcome was detection rates of advanced neoplasm(CRC and advanced adenoma)over 4 rounds.Secondary outcomes included screening participation,colonoscopy demand,and costs from a societal perspective.Long-term effectiveness and cost-effectiveness were modeled over 15 years using MIMIC-CRC.Results:Across 4 rounds,overall participation rates(attending at least one screening round)were 42.3%(colonoscopy),99.8%(FIT),and 92.5%(risk-adapted).Detection rates of advanced neoplasms were 2.8%,2.3%,and 2.6%,respectively,with no significant differences(P>0.05).Colonoscopies needed to detect 1 advanced neoplasm were 15.4,7.9,and 9.3,respectively.From a societal perspective,the cost for detecting 1 advanced neoplasm was 15,341,21,754,and 24,300 Chinese Yuan,respectively.Over 15 years,risk-adapted screening reduced incidence by 16.7%and mortality by 21.5%compared with no screening,slightly less effective than colonoscopy(24.6%and 24.8%,respectively).Under observed real-world adherence,colonoscopy was the most cost-effective;under perfect full adherence,risk-adapted screening was the most cost-effective.Conclusions:In this population-based CRC screening trial,risk-adapted screening,colonoscopy,and FIT demonstrated comparable effectiveness,but differed in participation rates,resource utilization,and cost-effectiveness.Risk-adapted screening could serve as a complementary approach to established strategies,particularly when health resources are limited.Trial registration:Chinese Clinical Trial Registry(ChiCTR1800015506).
基金Supported by the National Natural Science Foundation of China (Grant No.52475466)the National Key Laboratory of Science and Technology on Helicopter Transmission (Grant No.HTL-A-21G09)+1 种基金the National Science and Technology Major Project of China (Grant No.J2019-VII-0001–0141)the Youth Talent Support Project of Jiangsu Provincial Association of Science and Technology (Grant No.TJ-2023–056)。
摘要When milling structural components with varying axial depths and widths,cutting forces tend to fluctuate,negatively impacting tool life and machining accuracy.To mitigate the force fluctuations and enhance tool longevity,developing a simple,reliable,and easy-to-implement force control system for milling is essential,which is an important step toward advancing intelligent manufacturing.This paper explores the use of genetic algorithms(GA) for powerful optimization capabilities in developing self-tuning milling force controllers.A comprehensive framework for optimizing a fuzzy logic controller using an enhanced GA is specifically designed for the milling process.The optimization integrates the GA with a simulation model,fine-tuning membership functions and optimizing fuzzy rule selection.The enhanced GA incorporates the Integral of Time-weighted Absolute Error(ITAE) as the fitness criterion to improve the robustness and responsiveness of the controller.The optimized fuzzy logic controller is implemented within a computer numerical control system,adjusting feed rates in real-time to control milling forces.The performance of the proposed controller is validated through step and slope milling tests,demonstrating an average control accuracy of 95.52%.Comparative evaluations with other controllers show that the proposed system offers a significant improvement,achieving up to 4.58% better control accuracy in step milling tests.
基金the Capital Health Development Research Project:Research on the Treatment of Non-infectious Uveitis Based on Disease-Syndrome Combination”(No.2022-2-4174)Beijing Natural Science Foundation(No.7244501)+1 种基金Study on the Mechanism of Liangxue Sanjie Decoction in Treating Subretinal Fibrosis Secondary to Neovascular Age-related Macular Degeneration Based on mi R155-mediated Autophagy”(No.82405489)Hospital Capability Enhancement Project of Xiyuan Hospital,China Academy of Chinese Medical Sciences:a Randomized Controlled Trial of Acupuncture with Huoxue Tongluo Therapy for Neovascular Age-related Macular Degeneration(No.XYZX0202-10)。
摘要OBJECTIVE:To observe the clinical efficacy and safety of Chinese herbal medicine Jiawei Simiao Yongan granules(加味四妙勇安颗粒,JWSMYAG)in the treatment of non-infectious anterior uveitis(NIAU).METHODS:We conducted a single-center,randomized,open-labeled clinical trial in adults with NIAU.Patients received standard treatment or a combination of JWSMYAG(twice daily)for three months,with a 3-month withdrawal period for observation.The primary endpoint was the recurrence rate within six months.RESULTS:A total of 98 patients were included in the intention-to-treat analysis,including 49 patients in the Traditional Chinese Medicine(TCM)group and 49 patients in the control group.Compared with the control group,the number of relapses was significantly lower in the TCM group[24.5%vs 6.1%,P=0.0224;Hazard Ratio=0.208,95%Confidence Interval(0.059,0.737)];in addition,patients in the TCM group had lower symptom scores of eye pain,insomnia,and bitter taste within two weeks(all P10 mm Hg,the scoring of anterior chamber cells,the number of patients with keratic precipitates(+)after 1/2 weeks of treatment,and the scores of conjunctival hyperemia,headache,photophobia,and lacrimation.The difference in the number of adverse events between the two groups over six months was not statistically significant.CONCLUSION:JWSMYAG can reduce the recurrence rate of NIAU,alleviate ocular pain,insomnia,and bitter taste symptoms in patients with NIAU,and have a favorable safety profile.
基金supported by the National Natural Science Foundation of China(62472292,62471310,62376115)Guangdong Basic and Applied Basic Research Foundation(2025A1515011638)the Research Grants Council of the Hong Kong Special Administrative Region,China(GRF Project No.CityU11215622)。
摘要Few-for-many(F4M)optimization,recently introduced as a novel paradigm in multi-objective optimization,aims to find a small set of solutions that effectively handle a large number of conflicting objectives.Unlike traditional many-objective optimization methods,which typically attempt comprehensive coverage of the Pareto front,F4M optimization emphasizes finding a small representative solution set to efficiently address highdimensional objective spaces.Motivated by the computational complexity and practical relevance of F4M optimization,this paper proposes a new evolutionary algorithm explicitly tailored for efficiently solving F4M optimization problems.Inspired by Smetric selection evolutionary multi-objective optimization algorithm(SMS-EMOA),our proposed approach employs a(μ+1)-evolution strategy guided by the objective of F4M optimization.Furthermore,to facilitate rigorous performance assessment,we propose a novel benchmark test suite specifically designed for F4M optimization by leveraging the similarity betw een the R2indicator and F4M formulations.Our test suite is highly flexible,allowing any existing multi-objective optimization problem to be transformed into a corresponding F4M instance via scalarization using the weighted Tchebycheff function.Comprehensive experimental evaluations on benchmarks demonstrate the superior performance of our algorithm compared to existing state-of-the-art algorithms,especially on instances involving a large number of objectives.The source code of the proposed algorithm will be released publicly.Source code is available at http://gffzz188fe103f8f1460asnxcv9bw0c0qc6owp.ffgz.tsg.suse.edu.cn/MOL-SZU/SoM-EMOA.
摘要Objective:Conventional total hip arthroplasty(cTHA)may be technically challenging in some scenarios.Robotic-assisted THA(rTHA)was introduced in the 1980s with an active ROBODOC system.Considering the miscellaneous drawbacks of this early system,more recent semi-active systems were subsequently introduced.The present meta-analysis aimed to compare the operative and clinical outcomes of rTHA assisted by semi-active systems with those of cTHA in randomized controlled trials(RCTs).Methods:The present study was conducted in line with the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 expanded statement.Three databases were searched for relevant studies(July 2025)in English,including PubMed,Web of Science Core Collection and Scopus.The outcome data included the operative time,amount of intraoperative and total blood loss,duration of hospital stay,number of patients in the Lewinnek or Callanan safe zones,postoperative Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,postoperative Harris hip score and leg length discrepancy(LLD).The risk of bias in the included studies was assessed via the risk of bias assessment tool.Results:Eleven RCTs with 834 patients were included in this study.No significantdifferences were found between rTHA and cTHA regarding blood loss,hospital stay,WOMAC score or Harris hip score.While cTHA had a significantlyshorter operative duration(MD:22.12;95%CI:9.75,34.48),rTHA was associated with a significantlygreater frequency of patients in the Lewinnek(OR:4.11;95%CI:2.04,8.31)and Callanan(OR:3.93;95%CI:1.15,13.57)safe zones and a significantly lower LLD(SMD:-0.45;95%CI:-0.60,-0.30).Conclusion:Compared with cTHA,rTHA is a more accurate surgical technique with comparable blood loss,hospital stay and clinical scores.
基金National Key Research and Development Program of China,No.2023YFC3006704National Natural Science Foundation of China,No.42171047CAS-CSIRO Partnership Joint Project of 2024,No.177GJHZ2023097MI。
摘要Accurate prediction of flood events is important for flood control and risk management.Machine learning techniques contributed greatly to advances in flood predictions,and existing studies mainly focused on predicting flood resource variables using single or hybrid machine learning techniques.However,class-based flood predictions have rarely been investigated,which can aid in quickly diagnosing comprehensive flood characteristics and proposing targeted management strategies.This study proposed a prediction approach of flood regime metrics and event classes coupling machine learning algorithms with clustering-deduced membership degrees.Five algorithms were adopted for this exploration.Results showed that the class membership degrees accurately determined event classes with class hit rates up to 100%,compared with the four classes clustered from nine regime metrics.The nonlinear algorithms(Multiple Linear Regression,Random Forest,and least squares-Support Vector Machine)outperformed the linear techniques(Multiple Linear Regression and Stepwise Regression)in predicting flood regime metrics.The proposed approach well predicted flood event classes with average class hit rates of 66.0%-85.4%and 47.2%-76.0%in calibration and validation periods,respectively,particularly for the slow and late flood events.The predictive capability of the proposed prediction approach for flood regime metrics and classes was considerably stronger than that of hydrological modeling approach.
基金supported in part by the National Key Research and Development Program of China under Grant 2024YFE0201500in part by the National Natural Science Foundation of China under Grant 62334008,Grant 62274154,Grant 62534004,Grant 92464103,Grant 62404218,Grant 62134004。
摘要Single-photon avalanche diode(SPAD)image sensors are widely used in direct time-of-flight(D-TOF)imaging,but their ranging performance is often constrained by limited laser power.This article presents a SPAD-based D-TOF imaging system that combines a reconfigurable macro-pixel sensor architecture with a lightweight depth completion algorithm to achieve long-range depth imaging with enhanced spatial resolution under low optical power.The proposed sensor adopts a back-side illuminated(BSI)3D-stacked architecture with programmable macro-pixels that enhance detection sensitivity and enable flexible sensitivity–resolution trade-offs.An injection-locked ring-oscillator-based time-to-digital converter(RO-TDC)array achieves a time resolution of 152.5 ps,enabling accurate TOF measurement at an optical power of 10 mW.To compensate for macropixel-induced resolution loss,a probabilistic normalized convolutional neural network(pNCNN)is employed for depth completion using sparse depth inputs only.Experimental results demonstrate that up to 30×effective resolution enhancement of the system can be achieved via the depth completion algorithm without changing the physical resolution of the sensor.Additionally,the proposed system achieves a maximum ranging distance of 90 m and a range-to-power figure-of-merit(FOM)of9 m/mW,which validates the effectiveness of the system.
基金supported by the National Natural Science Foundation of China(12361106)the Guizhou Provincial Science and Technology Plan Key Project of Qiankehe Jichu(ZK[2023]003)the Guizhou Provincial High Level Innovative Talent Training Plan Project of Qiankehe Platform Talent(GCC[2023]006).
摘要The Marine Predators Algorithm(MPA),while promising for complex optimization,suffers from limited solution precision,imbalanced exploration–exploitation,and premature convergence.To address these shortcomings,this paper proposes a phased-enhancement variant named PEMPA,which integrates three novel strategies into distinct phases of MPA:1)embedding historical best positions in the high-velocity ratio phase to refine solution quality;2)introducing an adaptive inertia weight based on an inverted Sigmoid function in the unit-velocity ratio phase to systematically balance exploration and exploitation;and 3)designing a two-stage opposition-based learning operator in the low-velocity ratio phase to prevent premature convergence.The performance of PEMPA is comprehensively evaluated across 23 classical benchmark functions,the IEEE Congress on Evolutionary Computation(CEC)2017 test suite,21 feature selection tasks,and a real-world medical insurance fraud detection problem.Experimental results confirm that the proposed strategies significantly enhance the efficiency and robustness of MPA.Furthermore,PEMPA demonstrates highly competitive performance compared with several state-of-the-art metaheuristic algorithms,validating its effectiveness and scalability for diverse optimization challenges.
基金funded by the Postgraduate Research&Practice Innovation Programof Jiangsu Province,grant number SJCX25_0268(Zijie He).
摘要Constitutive modeling for geomaterials remains challenging because of limited data availability,strong nonlinearity,pressure sensitivity,and the non-smooth characteristics of commonly used yield surfaces.This study presents a deep-learning-based constitutive method for geomaterials that incorporates a neural stress-integration procedure based on the cutting plane algorithm(CPA).Two compact fully connected networks are trained to learn the yield function and its stress gradient from an augmented stress-state dataset.The trained networks are then incorporated into a cutting plane return-mapping procedure,in which only first-order information is required for the plastic stress return.This avoids explicit analytical yield expressions and second-derivative evaluations and is therefore more naturally compatible with non-smooth Mohr-Coulomb-type yield-surface representations in a first-order returnmapping sense.Numerical results show that the proposed method reproduces the reference Mohr-Coulomb response along the examined monotonic triaxial compression paths.Compared with the finite-difference closest-point projection method(CPPM)implementation considered in this study,the CPA-based neural stress-update procedure requires fewer network calls per update,indicating a more economical implementation for the present learned constitutive framework.
基金supported by National Key Research and Development Program Industrial Software Key Special Project(2022YFB3305100).
摘要The rapid growth of Internet of Things(IoT)and 5G technologies has led to a sharp increase in computing demands from wireless devices,making efficient task offloading a critical challenge.Key issues include reducing application latency,lowering the energy consumption of terminal devices,and improving overall system performance,all of which directly affect user experience.Traditional genetic algorithms(GA),inspired by biological evolution,have been widely used in task offloading,but they often suffer from slow convergence and a tendency to fall into local optima in complex scenarios,limiting their effectiveness.To address these drawbacks,this paper proposes a task offloading strategy based on a refined elite mechanism in a GA.The algorithm introduces multi-point variation in both crossover and mutation operations to enhance population diversity,avoid local optima,and accelerate convergence.This design leverages the GA’s strength in multi-objective optimization,which outperforms other bionic heuristic algorithms that excel in single domains.Comparative experiments with GA,ant colony optimization,Deep Q-Network,Greedy algorithms,simulated annealing algorithm and particle swarm optimization,show that the proposed algorithm improves convergence speed by 35%,reduces task completion time by 6%,and optimizes energy consumption by approximately 18%.
基金National Natural Science Foundation of China(32301712)Natural Science Foundation of Jiangsu Province(BK20230548,BK20250876)+2 种基金Project of Faculty of Agricultural Equipment of Jiangsu University(NGXB20240203)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD-2023-87)Open Funding Project of the Key Laboratory of Modern Agricultural Equipment and Technology(Jiangsu University),Ministry of Education(MAET202101)。
摘要Traditional sampling-based path planning algorithms,such as the rapidly-exploring random tree star(RRT*),encounter critical limitations in unstructured orchard environments,including low sampling efficiency in narrow passages,slow convergence,and high computational costs.To address these challenges,this paper proposes a novel hybrid global path planning algorithm integrating Gaussian sampling and quadtree optimization(RRT*-GSQ).This methodology aims to enhance path planning by synergistically combining a Gaussian mixture sampling strategy to improve node generation in critical regions,an adaptive step-size and direction optimization mechanism for enhanced obstacle avoidance,a Quadtree-AABB collision detection framework to lower computational complexity,and a dynamic iteration control strategy for more efficient convergence.In obstacle-free and obstructed scenarios,compared with the conventional RRT*,the proposed algorithm reduced the number of node evaluations by 67.57%and 62.72%,and decreased the search time by 79.72%and 78.52%,respectively.In path tracking tests,the proposed algorithm achieved substantial reductions in RMSE of the final path compared to the conventional RRT*.Specifically,the lateral RMSE was reduced by 41.5%in obstacle-free environments and 59.3%in obstructed environments,while the longitudinal RMSE was reduced by 57.2%and 58.5%,respectively.Furthermore,the maximum absolute errors in both lateral and longitudinal directions were constrained within 0.75 m.Field validation experiments in an operational orchard confirmed the algorithm's practical effectiveness,showing reductions in the mean tracking error of 47.6%(obstacle-free)and 58.3%(with obstructed),alongside a 5.1%and 7.2%shortening of the path length compared to the baseline method.The proposed algorithm effectively enhances path planning efficiency and navigation accuracy for robots,presenting a superior solution for high-precision autonomous navigation of agricultural robots in orchard environments and holding significant value for engineering applications.
摘要Background:The optimal sequencing of surgery and chemotherapy in advanced epithelial ovarian cancer remains debated.While primary debulking surgery(PDS)has been considered the standard approach,recent randomized trials have questioned its survival advantage over neoadjuvant chemotherapy(NACT)followed by interval debulking surgery(IDS).The study aimed to systematically evaluate phase Ⅲ randomized controlled trials comparing PDS and NACT.Methods:Following PRISMA guidelines(PROSPERO ID 1169057),PubMed and Scopus were systematically searched in October 2025 for phase Ⅲ randomized clinical trials evaluating cytoreductive strategies in ovarian carcinoma.Only full-text English studies reporting overall survival(OS)or disease-free survival(DFS)were included.Risk ratios(RR)with 95%confidence intervals(CI)were calculated.Results:Five phase Ⅲ trials(EORTC 55971,CHORUS,JCOG0602,SCORPION,TRUST)comprising 2296 patients met the inclusion criteria.PDS(n=1139)and NACT(n=1157)showed comparable OS(RR 0.99,95%CI 0.94-1.03,p=0.55,I2=0%)and DFS(PDS RR 0.98,95%CI 0.95-1.02,p=0.27,I2=0%).Subgroup analyses confirmed the absence of significant differences for patients with CC0(RR 0.96,95%CI 0.87-1.05,p=0.35,I2=0%),FIGO stage Ⅲ disease(RR 0.97,95%CI 0.92-1.03,p=0.34,I2=0%),or age under 70 years(RR 1.03,95%CI 0.97-1.09,p=0.38,I2=0%).Conclusions:PDS and NACT provide no significant survival outcomes in advanced ovarian cancer.No clear survival benefit for PDS was observed.Refinement of patient selection,integration of predictive biomarkers,and re-evaluation of PDS in the context of HIPEC and Poly-ADP-Ribose Polymerase(PARP)inhibitor use are warranted to guide individualized treatment strategies.