This study explored how psychology educators in South Africa can be professionally developed to embed Acceptance and Commitment Therapy(ACT)principles into their pedagogy,thereby enhancing psychological flexibility am...This study explored how psychology educators in South Africa can be professionally developed to embed Acceptance and Commitment Therapy(ACT)principles into their pedagogy,thereby enhancing psychological flexibility among postgraduate students.Using a Collaborative Action Research approach,seven educators and thirteen students participated in a ten-month intervention comprising four iterative cycles of training,implementation,and reflection.The thematic analysis found that ACT-informed pedagogy not only promoted student resilience,present-moment awareness(mindfulness),and values-based engagement(authenticity)but also catalysed shifts in educator identity toward more reflexive teaching.Students cultivated resilience by learning to tolerate emotional discomfort and sustain values-driven action,while developing mindfulness through present-moment awareness that fostered engagement.This process also nurtured authenticity,as students aligned their academic and professional identities with personally meaningful values,paralleled by educators’growing reflexivity and relational openness,signalling a values-informed pedagogy.These findings provide a theoretically grounded,contextually responsive model for cultivating soft skills in higher education,affirming the potential of ACT as a scalable,culturally congruent framework for professional development.展开更多
As power systems expand,solving the unit commitment problem(UCP)becomes increasingly challenging due to the curse of dimensionality,and traditional methods often struggle to balance computational efficiency and soluti...As power systems expand,solving the unit commitment problem(UCP)becomes increasingly challenging due to the curse of dimensionality,and traditional methods often struggle to balance computational efficiency and solution optimality.To tackle this issue,we propose a problem-structure-informed quantum approximate optimization algorithm(QAOA)framework that fully exploits the quantum advantage under extremely limited quantum resources.Specifically,we leverage the inherent topological structure of power systems to decompose large-scale UCP instances into smaller subproblems,which are solvable in parallel by limited number of qubits.This decomposition not only circumvents the current hardware limitations of quantum computing but also achieves higher performance as the graph structure of the power system becomes more sparse.Consequently,our approach can be extended to future power systems that are larger and more complex.展开更多
The biodegradable polybutylene succinate(PBS)material offers a sustainable solution for a circular economy to address the global issue of marine plastic waste.Its cross-linkage with non-biodegradable xanthan gum(XG)bi...The biodegradable polybutylene succinate(PBS)material offers a sustainable solution for a circular economy to address the global issue of marine plastic waste.Its cross-linkage with non-biodegradable xanthan gum(XG)biopolymer to ameliorate residual granitic soil(RGS)in arid and semiarid regions can significantly mitigate soil erosion.This study investigates the enhancement of RGS by cross-linking the PBS and XG biopolymers.Employing a multitude of geotechnical tests(liquid limit,linear shrinkage,specific gravity,compaction,and UCS tests)at 3 d,28 d,and 90 d of steam-curing at a controlled temperature of 16℃,the outcomes were validated through scanning electron microscopy(SEM),thermogravimetric analysis(TGA),Fourier transform infrared spectroscopy(FTIR),and Brunauer-Emmett-Teller(BET)analyses.In addition,a comprehensive experimental database of 150 tests and nine parameters from the current study was utilized to model the UCS90-d(i.e.unconfined compressive strength after 90 d of curing)of the PBS-XG-treated RGS mixtures by deploying the random forest(RF)and eXtreme Gradient Boost(XGBoost)methods.The results found that the two biopolymers significantly improve the mechanical properties of RGS,with optimal UCS achieved at specific dosages(0.4PBS,1.5XG,and 0.2PBS+1.5XG dosage levels)and curing times.The UCS of PBS-XG-treated RGS showed up to a 57%increase after 90 d of curing.Furthermore,SEM and FTIR analyses revealed the formation of stronger microstructures and chemical bonds,respectively,whereas BET analysis indicated that pore volume and diameter are critical in affecting UCS.The proposed RF model outperformed XGBoost in predictive accuracy and generalization,demonstrating robustness and versatility.Moreover,SHAP values highlighted the significant impact of input parameters on UCS90-d,with curing time and specific material properties being key determinants.The study concludes with the proposal of a novel PyCharm intuitive graphical user interface as a"UCS Prediction App"for engineers and practitioners to forecast the UCS90-d of granitic residual soil.展开更多
Ulcerative colitis(UC)is an idiopathic,chronic inflammatory disorder with an increasing incidence worldwide.Due to the complex and unclear therapeutic targets,unmet UC therapeutic drugs still exist.Recently,acylcarnit...Ulcerative colitis(UC)is an idiopathic,chronic inflammatory disorder with an increasing incidence worldwide.Due to the complex and unclear therapeutic targets,unmet UC therapeutic drugs still exist.Recently,acylcarnitine metabolism disorder has been linked to intestinal inflammation,but its role in UC remains elusive.According to our preliminary non-targeted metabolomics data,acylcarnitines(ACs)was screened as the disturbed metabolites in the different intestinal inflammation-related diseases.Here we quantified 26 ACs within liquid chromatography-tandem mass spectrometry(LC-MS/MS)in the dextran sulfate sodium(DSS)-induced UC rat model,and found that long-chain acylcarnitines(LCACs)were increased to varying degrees.As the key metabolites of fatty acidβ-oxidation(FAO),the upstream metabolites long-chain fatty acids(LCFAs)and the related metabolic enzymes were further characterized,the results showed that the rate-limiting enzyme carnitine palmitoyltransferase 1A(CPT1A)-mediated LCFAs-LCACs metabolic axis was activated sharply.Next in vitro experiments exhibited that CPT1A was significantly upregulated in both inflammatory macrophages and colonic epithelial cells,and inhibition or knockdown of CPT1A could reduce the inflammation level remarkably.Thus,we screened the pharmacologic inhibitors of CPT1A from US Food and Drug Administration(FDA)approved drugs,within molecular docking,Western blot and cell membrane chromatography(CMC)technology,gliquidone was found to inhibit CPT1A in a dose-dependent manner and exert anti-inflammatory effects in vitro.Animal experiments also showed that gliquidone alleviated DSS-induced UC significantly.In summary,our study presents that within metabolomics analysis,inhibiting CPT1A is focused to be a potential therapeutic strategy against UC,and gliquidone represents an alternative treatment.展开更多
Soft clay treatment with all industrial by-product(IBP)binder has great economic and environmental benefits,yet its geomechanics and mechanisms still need to be well probed.With the activation by calcium carbide resid...Soft clay treatment with all industrial by-product(IBP)binder has great economic and environmental benefits,yet its geomechanics and mechanisms still need to be well probed.With the activation by calcium carbide residue(CCR)and phosphogypsum(PG),the strength,structure,and mechanisms of soft clay treated by aluminosilicate-rich IBP(AS-IBP,such as ground granulated blast furnace slag(GGBS),fly ash(FA),coal gangue(CG),Bayer red mud(BR),and sintered red mud(SR))are comparatively investigated.The strength characteristics of solidified clay exhibit significant differences as AS-IBP changes.When GGBS is adopted,the strength is sensitive to the change in PG content,while the impact of CCR is insignificant.After 90 d,the strength of the optimal sample(G23)reaches 1.40 MPa,35.9%higher than cement solidified clay(CSC),while that achieved by other AS-IBPs is less than 0.3 MPa.In the compression test,the structure's evolutionary trend of G23 has a sudden change as the strength increases from 1.81 MPa to 2.29 MPa,suggesting the transformation in material properties.Besides,the structure of G23 is stronger than CSC,which contributes more to the compressive performance.The total amount of main products(C-S-H and ettringite)of all-IBP solidified clay determines the strength,and ettringite is only significant when calcium-rich AS-IBP is adopted.The total amount of minor products(C-A-H and C-A-S-H)is similar for different samples,equivalent to 28.9%-46.3%of the main products.The relationship between the strength and the product amount can be presented using an exponential function.展开更多
集成电路测试机(Automatic Test Equipment,ATE)是用于验证芯片功能与性能的核心设备,传统测试方法存在效率低、精度不足等问题,为此提出一种基于ST3020 ATE测试机的自动测试方案,该设备具备自动化、高效率、高精度、宽量程、高灵活性...集成电路测试机(Automatic Test Equipment,ATE)是用于验证芯片功能与性能的核心设备,传统测试方法存在效率低、精度不足等问题,为此提出一种基于ST3020 ATE测试机的自动测试方案,该设备具备自动化、高效率、高精度、宽量程、高灵活性与良好扩展性等特点。以芯片UC2625为测试对象,通过软件层面编写自动测试代码,硬件层面设计接口板PCB,结合循环测试、数组存储与比对等技术,系统研究了该芯片的逻辑功能与关键参数指标,最终实现了完整的ATE自动测试方案。测试结果与芯片手册规格相符,满足实际测试要求。方案在自动测试方法上进行了有益探索,为我国ATE测试技术的自主发展提供了重要参考。展开更多
Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the na...Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the national oil company of Oman,Petroleum Development Oman(PDO).展开更多
The interrogation of duty-related crimes committed by judicial personnel faces practical dilemmas,including suspects'strong counter-interrogation capabilities,complex nested case relationships,and a disruption in ...The interrogation of duty-related crimes committed by judicial personnel faces practical dilemmas,including suspects'strong counter-interrogation capabilities,complex nested case relationships,and a disruption in the transmission of experiential knowledge.In response,a structured interrogation method anchored in cognitive dissonance theory can be constructed.By applying external information interventions to disrupt suspects'ingrained professional mindsets,and by generating and resolving cognitive conflicts,this approach facilitates a shift in confession attitudes.Supported by digital-intelligence technologies and ancillary mechanisms such as a strategy repository and a closed-loop leads integration system,the method converts tacit individual expertise into reusable organizational knowledge.This offers an actionable pathway for enhancing the quality and efficiency of prosecutorial investigations and for resolving the tensions inherent in internal supervision mechanisms.展开更多
The enhancement of the intensity of red upconversion(UC)emission has significant implications for biological applications.In KZnF3:Yb3+,Er3+which inherently produces high-purity red emission,the introduction ...The enhancement of the intensity of red upconversion(UC)emission has significant implications for biological applications.In KZnF3:Yb3+,Er3+which inherently produces high-purity red emission,the introduction of Fe3+markedly improves the UC intensity by a factor of 13.The mechanism behind the enhanced UC red luminescence is deduced to originate from the Yb3+-Fe3+dimer,as determined by first principle calculation and analysis of UC luminescence properties.The thermometry performance,based on splitting peaks of red emission,demonstrated enhanced temperature sensitivity at lower ranges.Exploring the photothermal properties,it was observed that temperature exhibited a linear correlation with pump power under a 980 nm laser,achieving levels up to 48℃.This temperature range is ideal for applications in mild photothermal therapy(MPTT).This work elucidates the material’s potential in advanced biological applications,merging optical thermometry and photothermics,indicating its multifunctional utility.展开更多
In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of...In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of area-wide system strength in power systems with high inverter-based resource(IBR)penetration,thereby contributing to the mitigation of weak grid issues.Unlike traditional models,this approach considers the interactions among multiple IBRs.The UC problem is initially formulated as a mixed-integer nonlinear programming(MINLP)model,reflecting WSCR and bus impedance matrix modification constraints.To enhance computational tractability,the model is transformed into a mixed-integer linear programming(MILP)form.The effectiveness of the proposed approach is validated through simulations on the IEEE 5-bus,IEEE 39-bus,and a modified Korean power system,demonstrating the ability of the proposed UC model enhancing system strength compared to the conventional methodologies.展开更多
Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study exam...Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.展开更多
To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy stora...To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy storage,incorporating daily minimum chargeable energy constraints,was developed.Firstly,considering the variations in the frequency of unit start-ups and shutdowns under different levels of net load fluctuation,a method was proposed to reduce decision time periods for unit start-up and shut-down operations.This approach,based on the characteristics of net load fluctuations,minimizes the decision variables of units,thereby simplifying the monthly schedulingmodel.Secondly,the relationship between energy storage charging and discharging power,net load,and the total maximum/minimum output of units was analyzed.Based on this,daily minimum chargeable energy constraints were established to ensure the energy storage system meets charging requirements under extreme net load scenarios.Finally,taking into account the operational costs of thermal generators and energy storage,load loss costs,and operational constraints,the reduced time-period monthly schedulingmodel was constructed.Case studies demonstrate that the proposedmethod effectively generates economical monthly operation plans for thermal generators and energy storage,significantly reduces model solution time,and satisfies the charging requirements of energy storage under extreme net load conditions.展开更多
Unit commitment(UC), as a typical optimization problem in electric power system, faces new challenges as energy saving and emission reduction get more and more important in the way to a more environmentally friendly s...Unit commitment(UC), as a typical optimization problem in electric power system, faces new challenges as energy saving and emission reduction get more and more important in the way to a more environmentally friendly society. To meet these challenges, we propose a UC model considering energy saving and emission reduction. By using real-number coding method, swap-window and hill-climbing operators, we present an improved real-coded genetic algorithm(IRGA) for UC. Compared with other algorithms approach to the proposed UC problem, the IRGA solution shows an improvement in effectiveness and computational time.展开更多
Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,...Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,little attention has been paid to the influence of humic substances on the EICP.Humic substances cover most of the surface soil across the world land with vegetation,which varies according to the density of vegetation and climate.To understand the compatibility of this technique to distinct problematic soils,it is important to figure out how humic substances could affect the carbonate precipitation process induced by urease enzyme.Therefore,this study aims to investigate the effects of humic acid(HA),one type of humic substance,on the soil solidification through EICP.For this purpose,HA was added to natural soil with varying addition amounts(0%,1%,2%,4%,8%,16%)in soil column solidification tests.The results found that the cementation effectiveness was enhanced by a small amount of HA addition(<4%),while an addition up to 8%greatly inhibited the formation of calcium carbonate.At the same time,soil samples were buffered by HA in a weak acidic condition,thus preventing the emission of undesirable by-product ammonia in the ureolysis process.Therefore,this study makes a contribution to research on enzymatic biocementation by demonstrating the effects of HA on the cementation effectiveness of EICP technique.展开更多
Although soil exhibits excellent mechanical performance,the microstructural changes of biopolymer within soil due to dehydration and rehydration are rarely explored.This study aims to explore xanthan gum soil microstr...Although soil exhibits excellent mechanical performance,the microstructural changes of biopolymer within soil due to dehydration and rehydration are rarely explored.This study aims to explore xanthan gum soil microstructure and strength behavior under different dehydration and rehydration degrees using nuclear magnetic resonance(NMR)and unconfined compressive strength tests.The results showed that the proportion of large-volume biopolymer gel within the sample decreased from 91.91%to 38.28%during dehydration,but increased to 90.44%upon rehydration when sample moisture returned to its original level.The NMR images revealed that biopolymer gel evaporated from outside during the dehydration process,causing the dehydrated biopolymer to shrink and form a high-strength glass,which directly enhanced the soil's macroscopic mechanical properties.Upon rehydration,the biopolymer reabsorbed moisture and gradually expanded,leading to weakened connections between soil particles and a decrease in strength.Therefore,even when the moisture content of soil remained constant during the dehydration and rehydration processes,their unconfined compressive strength(UCS)and failure patterns exhibited significant differences.Both the UCS and NMR signal of biopolymer-treated soil decreased after the first dehydration and rehydration cycle,stabilizing gradually after subsequent cycles.展开更多
Objective:To study the relationship,the mediating effect of organizational commitment on nurses’ethical climate and ethical behavior.Methods:Structural Equation Modeling(SEM)was employed to perform path analysis in t...Objective:To study the relationship,the mediating effect of organizational commitment on nurses’ethical climate and ethical behavior.Methods:Structural Equation Modeling(SEM)was employed to perform path analysis in this exploratory study.The participants consisted of 280 Iranian nurses who were studied through proportional random sampling.The research tool was consisted of(1)the Ethical Climate Questionnaire by Cullen and Victor,which examines the ethical standards of selfishness,philanthropy,and ethical principles,as well as the reference sources of ethical arguments,including individual,regional,and global ones;(2)Allen and Mayer’s questionnaire,which measures organizational commitment in 3 areas:emotional commitment,continuous commitment,and normative commitment;and(3)Peterson’s Ethical Behavior Questionnaire,which combines nine items to form interconnected ethical behaviors and is based on a 5-point Likert scale.The data were analyzed using AMOS and SPSS v.23 software.Results:The correlation coefficient between the two variables,ethical climate and ethical behavior,showed a significant relationship(r=0.10,p=0.085).The organizational commitment showed a significant relationship between some dimensions and the total ethical climate.The ethical climate affects the organizational commitment(beta=3.261)and behavior(beta=0.121).Organizational commitment does not show any significant relationship with ethical behavior.The ethical climate affects the organizational commitment and the ethical behavior.Conclusions:Nursing managers and nursing staff should consider the ethical climate that affects the organizational commitment and nursing ethical behavior.展开更多
The quantum hybrid algorithm has recently become a very promising and speedy method for solving larger-scale optimization problems in the noisy intermediate-scale quantum(NISQ)era.The unit commitment(UC)problem is a f...The quantum hybrid algorithm has recently become a very promising and speedy method for solving larger-scale optimization problems in the noisy intermediate-scale quantum(NISQ)era.The unit commitment(UC)problem is a fundamental problem in the field of power systems that aims to satisfy the power balance constraint with minimal cost.In this paper,we focus on the implementation of the UC solution using exact quantum algorithms based on the quantum neural network(QNN).This method is tested with a ten-unit system under the power balance constraint.In order to improve computing precision and reduce network complexity,we propose a knowledge-based partially connected quantum neural network(PCQNN).The results show that exact solutions can be obtained by the improved algorithm and that the depth of the quantum circuit can be reduced simultaneously.展开更多
摘要This study explored how psychology educators in South Africa can be professionally developed to embed Acceptance and Commitment Therapy(ACT)principles into their pedagogy,thereby enhancing psychological flexibility among postgraduate students.Using a Collaborative Action Research approach,seven educators and thirteen students participated in a ten-month intervention comprising four iterative cycles of training,implementation,and reflection.The thematic analysis found that ACT-informed pedagogy not only promoted student resilience,present-moment awareness(mindfulness),and values-based engagement(authenticity)but also catalysed shifts in educator identity toward more reflexive teaching.Students cultivated resilience by learning to tolerate emotional discomfort and sustain values-driven action,while developing mindfulness through present-moment awareness that fostered engagement.This process also nurtured authenticity,as students aligned their academic and professional identities with personally meaningful values,paralleled by educators’growing reflexivity and relational openness,signalling a values-informed pedagogy.These findings provide a theoretically grounded,contextually responsive model for cultivating soft skills in higher education,affirming the potential of ACT as a scalable,culturally congruent framework for professional development.
摘要As power systems expand,solving the unit commitment problem(UCP)becomes increasingly challenging due to the curse of dimensionality,and traditional methods often struggle to balance computational efficiency and solution optimality.To tackle this issue,we propose a problem-structure-informed quantum approximate optimization algorithm(QAOA)framework that fully exploits the quantum advantage under extremely limited quantum resources.Specifically,we leverage the inherent topological structure of power systems to decompose large-scale UCP instances into smaller subproblems,which are solvable in parallel by limited number of qubits.This decomposition not only circumvents the current hardware limitations of quantum computing but also achieves higher performance as the graph structure of the power system becomes more sparse.Consequently,our approach can be extended to future power systems that are larger and more complex.
基金supported by the National Natural Science Foundation of China(Grant Nos.52379104 and 52090084).
摘要The biodegradable polybutylene succinate(PBS)material offers a sustainable solution for a circular economy to address the global issue of marine plastic waste.Its cross-linkage with non-biodegradable xanthan gum(XG)biopolymer to ameliorate residual granitic soil(RGS)in arid and semiarid regions can significantly mitigate soil erosion.This study investigates the enhancement of RGS by cross-linking the PBS and XG biopolymers.Employing a multitude of geotechnical tests(liquid limit,linear shrinkage,specific gravity,compaction,and UCS tests)at 3 d,28 d,and 90 d of steam-curing at a controlled temperature of 16℃,the outcomes were validated through scanning electron microscopy(SEM),thermogravimetric analysis(TGA),Fourier transform infrared spectroscopy(FTIR),and Brunauer-Emmett-Teller(BET)analyses.In addition,a comprehensive experimental database of 150 tests and nine parameters from the current study was utilized to model the UCS90-d(i.e.unconfined compressive strength after 90 d of curing)of the PBS-XG-treated RGS mixtures by deploying the random forest(RF)and eXtreme Gradient Boost(XGBoost)methods.The results found that the two biopolymers significantly improve the mechanical properties of RGS,with optimal UCS achieved at specific dosages(0.4PBS,1.5XG,and 0.2PBS+1.5XG dosage levels)and curing times.The UCS of PBS-XG-treated RGS showed up to a 57%increase after 90 d of curing.Furthermore,SEM and FTIR analyses revealed the formation of stronger microstructures and chemical bonds,respectively,whereas BET analysis indicated that pore volume and diameter are critical in affecting UCS.The proposed RF model outperformed XGBoost in predictive accuracy and generalization,demonstrating robustness and versatility.Moreover,SHAP values highlighted the significant impact of input parameters on UCS90-d,with curing time and specific material properties being key determinants.The study concludes with the proposal of a novel PyCharm intuitive graphical user interface as a"UCS Prediction App"for engineers and practitioners to forecast the UCS90-d of granitic residual soil.
基金supported by the National Natural Science Foundation of China(Grant Nos.:82273896,82473883,and U24A20788)the Fundamental Research Funds for the Central Universities(Gramt No.:2632024ZD02)+2 种基金a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,Project Program of State Key Laboratory of Natural Medicines(China Pharmaceutical University,Program No.:SKLNMZZ2024JS21)the Natural Science Foundation of Shaanxi Province(Grant No.:2024JC-YBQN-0941)the Key Research and Development Projects of Shaanxi Province(Project No.:2023-YBSF-504).
摘要Ulcerative colitis(UC)is an idiopathic,chronic inflammatory disorder with an increasing incidence worldwide.Due to the complex and unclear therapeutic targets,unmet UC therapeutic drugs still exist.Recently,acylcarnitine metabolism disorder has been linked to intestinal inflammation,but its role in UC remains elusive.According to our preliminary non-targeted metabolomics data,acylcarnitines(ACs)was screened as the disturbed metabolites in the different intestinal inflammation-related diseases.Here we quantified 26 ACs within liquid chromatography-tandem mass spectrometry(LC-MS/MS)in the dextran sulfate sodium(DSS)-induced UC rat model,and found that long-chain acylcarnitines(LCACs)were increased to varying degrees.As the key metabolites of fatty acidβ-oxidation(FAO),the upstream metabolites long-chain fatty acids(LCFAs)and the related metabolic enzymes were further characterized,the results showed that the rate-limiting enzyme carnitine palmitoyltransferase 1A(CPT1A)-mediated LCFAs-LCACs metabolic axis was activated sharply.Next in vitro experiments exhibited that CPT1A was significantly upregulated in both inflammatory macrophages and colonic epithelial cells,and inhibition or knockdown of CPT1A could reduce the inflammation level remarkably.Thus,we screened the pharmacologic inhibitors of CPT1A from US Food and Drug Administration(FDA)approved drugs,within molecular docking,Western blot and cell membrane chromatography(CMC)technology,gliquidone was found to inhibit CPT1A in a dose-dependent manner and exert anti-inflammatory effects in vitro.Animal experiments also showed that gliquidone alleviated DSS-induced UC significantly.In summary,our study presents that within metabolomics analysis,inhibiting CPT1A is focused to be a potential therapeutic strategy against UC,and gliquidone represents an alternative treatment.
基金supported by the National Natural Science Foundation of China(Grant No.U24A20183)Natural Science Fund for Distinguished Young Scholars of Hubei Province,China(Grant No.2024AFA051)Youth Science Fund(A-class)of Hunan Natural Science Foundation of China(Grant No.2025JJ20049).
摘要Soft clay treatment with all industrial by-product(IBP)binder has great economic and environmental benefits,yet its geomechanics and mechanisms still need to be well probed.With the activation by calcium carbide residue(CCR)and phosphogypsum(PG),the strength,structure,and mechanisms of soft clay treated by aluminosilicate-rich IBP(AS-IBP,such as ground granulated blast furnace slag(GGBS),fly ash(FA),coal gangue(CG),Bayer red mud(BR),and sintered red mud(SR))are comparatively investigated.The strength characteristics of solidified clay exhibit significant differences as AS-IBP changes.When GGBS is adopted,the strength is sensitive to the change in PG content,while the impact of CCR is insignificant.After 90 d,the strength of the optimal sample(G23)reaches 1.40 MPa,35.9%higher than cement solidified clay(CSC),while that achieved by other AS-IBPs is less than 0.3 MPa.In the compression test,the structure's evolutionary trend of G23 has a sudden change as the strength increases from 1.81 MPa to 2.29 MPa,suggesting the transformation in material properties.Besides,the structure of G23 is stronger than CSC,which contributes more to the compressive performance.The total amount of main products(C-S-H and ettringite)of all-IBP solidified clay determines the strength,and ettringite is only significant when calcium-rich AS-IBP is adopted.The total amount of minor products(C-A-H and C-A-S-H)is similar for different samples,equivalent to 28.9%-46.3%of the main products.The relationship between the strength and the product amount can be presented using an exponential function.
摘要集成电路测试机(Automatic Test Equipment,ATE)是用于验证芯片功能与性能的核心设备,传统测试方法存在效率低、精度不足等问题,为此提出一种基于ST3020 ATE测试机的自动测试方案,该设备具备自动化、高效率、高精度、宽量程、高灵活性与良好扩展性等特点。以芯片UC2625为测试对象,通过软件层面编写自动测试代码,硬件层面设计接口板PCB,结合循环测试、数组存储与比对等技术,系统研究了该芯片的逻辑功能与关键参数指标,最终实现了完整的ATE自动测试方案。测试结果与芯片手册规格相符,满足实际测试要求。方案在自动测试方法上进行了有益探索,为我国ATE测试技术的自主发展提供了重要参考。
摘要Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the national oil company of Oman,Petroleum Development Oman(PDO).
摘要The interrogation of duty-related crimes committed by judicial personnel faces practical dilemmas,including suspects'strong counter-interrogation capabilities,complex nested case relationships,and a disruption in the transmission of experiential knowledge.In response,a structured interrogation method anchored in cognitive dissonance theory can be constructed.By applying external information interventions to disrupt suspects'ingrained professional mindsets,and by generating and resolving cognitive conflicts,this approach facilitates a shift in confession attitudes.Supported by digital-intelligence technologies and ancillary mechanisms such as a strategy repository and a closed-loop leads integration system,the method converts tacit individual expertise into reusable organizational knowledge.This offers an actionable pathway for enhancing the quality and efficiency of prosecutorial investigations and for resolving the tensions inherent in internal supervision mechanisms.
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),"Qinglan Project"Young and Middle-aged Academic Leaders Program of Jiangsu Province,and the National Natural Science Foundation of China(General Program).
摘要The enhancement of the intensity of red upconversion(UC)emission has significant implications for biological applications.In KZnF3:Yb3+,Er3+which inherently produces high-purity red emission,the introduction of Fe3+markedly improves the UC intensity by a factor of 13.The mechanism behind the enhanced UC red luminescence is deduced to originate from the Yb3+-Fe3+dimer,as determined by first principle calculation and analysis of UC luminescence properties.The thermometry performance,based on splitting peaks of red emission,demonstrated enhanced temperature sensitivity at lower ranges.Exploring the photothermal properties,it was observed that temperature exhibited a linear correlation with pump power under a 980 nm laser,achieving levels up to 48℃.This temperature range is ideal for applications in mild photothermal therapy(MPTT).This work elucidates the material’s potential in advanced biological applications,merging optical thermometry and photothermics,indicating its multifunctional utility.
基金partially supported by Korea Electrotechnology Research Institute(KERI)Primary research program through the National Research Council of Science&Technology(NST)funded by the Ministry of Science and ICT(MSIT)(No.25A01038)partially supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2024-00218377).
摘要In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of area-wide system strength in power systems with high inverter-based resource(IBR)penetration,thereby contributing to the mitigation of weak grid issues.Unlike traditional models,this approach considers the interactions among multiple IBRs.The UC problem is initially formulated as a mixed-integer nonlinear programming(MINLP)model,reflecting WSCR and bus impedance matrix modification constraints.To enhance computational tractability,the model is transformed into a mixed-integer linear programming(MILP)form.The effectiveness of the proposed approach is validated through simulations on the IEEE 5-bus,IEEE 39-bus,and a modified Korean power system,demonstrating the ability of the proposed UC model enhancing system strength compared to the conventional methodologies.
基金funded by the Education and Teaching Reform Research Major Project of Anhui Province(2022xqhz023)(2023sx170).
摘要Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.
基金This study was supported by State Grid Corporation headquarters technology project(4000-202399368A-2-2-ZB).
摘要To address the excessive complexity of monthly scheduling and the impact of uncertain net load on the chargeable energy of storage,a reduced time-period monthly scheduling model for thermal generators and energy storage,incorporating daily minimum chargeable energy constraints,was developed.Firstly,considering the variations in the frequency of unit start-ups and shutdowns under different levels of net load fluctuation,a method was proposed to reduce decision time periods for unit start-up and shut-down operations.This approach,based on the characteristics of net load fluctuations,minimizes the decision variables of units,thereby simplifying the monthly schedulingmodel.Secondly,the relationship between energy storage charging and discharging power,net load,and the total maximum/minimum output of units was analyzed.Based on this,daily minimum chargeable energy constraints were established to ensure the energy storage system meets charging requirements under extreme net load scenarios.Finally,taking into account the operational costs of thermal generators and energy storage,load loss costs,and operational constraints,the reduced time-period monthly schedulingmodel was constructed.Case studies demonstrate that the proposedmethod effectively generates economical monthly operation plans for thermal generators and energy storage,significantly reduces model solution time,and satisfies the charging requirements of energy storage under extreme net load conditions.
基金the National Natural Science Foundation of China(Nos.61004088 and 61374160)
摘要Unit commitment(UC), as a typical optimization problem in electric power system, faces new challenges as energy saving and emission reduction get more and more important in the way to a more environmentally friendly society. To meet these challenges, we propose a UC model considering energy saving and emission reduction. By using real-number coding method, swap-window and hill-climbing operators, we present an improved real-coded genetic algorithm(IRGA) for UC. Compared with other algorithms approach to the proposed UC problem, the IRGA solution shows an improvement in effectiveness and computational time.
基金JST SPRING,Grant Number JPMJSP2119Japan Society for the Promotion of Science(JSPS)KAKENHI Grant Number JP22H01581。
摘要Enzyme induced carbonate precipitation(EICP)is a promising technique in the field of biocementation due to its efficiency and controllability.Although many studies have proved its reliability in different environment,little attention has been paid to the influence of humic substances on the EICP.Humic substances cover most of the surface soil across the world land with vegetation,which varies according to the density of vegetation and climate.To understand the compatibility of this technique to distinct problematic soils,it is important to figure out how humic substances could affect the carbonate precipitation process induced by urease enzyme.Therefore,this study aims to investigate the effects of humic acid(HA),one type of humic substance,on the soil solidification through EICP.For this purpose,HA was added to natural soil with varying addition amounts(0%,1%,2%,4%,8%,16%)in soil column solidification tests.The results found that the cementation effectiveness was enhanced by a small amount of HA addition(<4%),while an addition up to 8%greatly inhibited the formation of calcium carbonate.At the same time,soil samples were buffered by HA in a weak acidic condition,thus preventing the emission of undesirable by-product ammonia in the ureolysis process.Therefore,this study makes a contribution to research on enzymatic biocementation by demonstrating the effects of HA on the cementation effectiveness of EICP technique.
基金supported by the National Natural Science Foundation of China(Grant No.42102324)the Natural Science Foundation of Hubei Province of China(Grant No.2024AFB686)Open Fund of Badong National Observation and Research Station of Geohazards(Grant No.BNORSG-202102).
摘要Although soil exhibits excellent mechanical performance,the microstructural changes of biopolymer within soil due to dehydration and rehydration are rarely explored.This study aims to explore xanthan gum soil microstructure and strength behavior under different dehydration and rehydration degrees using nuclear magnetic resonance(NMR)and unconfined compressive strength tests.The results showed that the proportion of large-volume biopolymer gel within the sample decreased from 91.91%to 38.28%during dehydration,but increased to 90.44%upon rehydration when sample moisture returned to its original level.The NMR images revealed that biopolymer gel evaporated from outside during the dehydration process,causing the dehydrated biopolymer to shrink and form a high-strength glass,which directly enhanced the soil's macroscopic mechanical properties.Upon rehydration,the biopolymer reabsorbed moisture and gradually expanded,leading to weakened connections between soil particles and a decrease in strength.Therefore,even when the moisture content of soil remained constant during the dehydration and rehydration processes,their unconfined compressive strength(UCS)and failure patterns exhibited significant differences.Both the UCS and NMR signal of biopolymer-treated soil decreased after the first dehydration and rehydration cycle,stabilizing gradually after subsequent cycles.
基金supported by The Mediating Effect of Organizational Commitment on Nurses’Ethical Climate and Ethical Behavior(No.IR.UMSHA.REC.1396.601).
摘要Objective:To study the relationship,the mediating effect of organizational commitment on nurses’ethical climate and ethical behavior.Methods:Structural Equation Modeling(SEM)was employed to perform path analysis in this exploratory study.The participants consisted of 280 Iranian nurses who were studied through proportional random sampling.The research tool was consisted of(1)the Ethical Climate Questionnaire by Cullen and Victor,which examines the ethical standards of selfishness,philanthropy,and ethical principles,as well as the reference sources of ethical arguments,including individual,regional,and global ones;(2)Allen and Mayer’s questionnaire,which measures organizational commitment in 3 areas:emotional commitment,continuous commitment,and normative commitment;and(3)Peterson’s Ethical Behavior Questionnaire,which combines nine items to form interconnected ethical behaviors and is based on a 5-point Likert scale.The data were analyzed using AMOS and SPSS v.23 software.Results:The correlation coefficient between the two variables,ethical climate and ethical behavior,showed a significant relationship(r=0.10,p=0.085).The organizational commitment showed a significant relationship between some dimensions and the total ethical climate.The ethical climate affects the organizational commitment(beta=3.261)and behavior(beta=0.121).Organizational commitment does not show any significant relationship with ethical behavior.The ethical climate affects the organizational commitment and the ethical behavior.Conclusions:Nursing managers and nursing staff should consider the ethical climate that affects the organizational commitment and nursing ethical behavior.
基金supported in part by the China Postdoctoral Science Foundation(Grant No.2023M740874)。
摘要The quantum hybrid algorithm has recently become a very promising and speedy method for solving larger-scale optimization problems in the noisy intermediate-scale quantum(NISQ)era.The unit commitment(UC)problem is a fundamental problem in the field of power systems that aims to satisfy the power balance constraint with minimal cost.In this paper,we focus on the implementation of the UC solution using exact quantum algorithms based on the quantum neural network(QNN).This method is tested with a ten-unit system under the power balance constraint.In order to improve computing precision and reduce network complexity,we propose a knowledge-based partially connected quantum neural network(PCQNN).The results show that exact solutions can be obtained by the improved algorithm and that the depth of the quantum circuit can be reduced simultaneously.