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Prediction of lithium content in typical mountainous clay in Xinjiang,China using fractional derivatives and feature extraction 认领 引用
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作者 JIANG Guo CUI Shichao +6 位作者 CHEN Xi CHEN Xi WANG Jinlin CHEN Tao ZHOU Shuguang ZHANG Zhengfeng XU Xiaozhi 《Journal of Mountain Science》 SCIE CSCD 2026年第2期545-558,共14页
Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral ... Lithium(Li)is an‘emerging'environmental pollutant,especially in soil,which is a great concern because it can endanger human health through the food chain.Compared with traditional chemical analyses,hyperspectral techniques have achieved many exciting results in soil metal monitoring due to their advantages of being fast and non-destructive.However,insufficient attention has been paid to lithium in soil,and the feasibility of its estimation using hyperspectral techniques needs to be investigated.We studied 97 soil samples from claytype lithium mines in the Ertanggou area of the East Tianshan Mountains of Xinjiang to explore the effects of spectral resolution,fractional order derivatives(FOD),and characteristic band selection on the estimation accuracy of clay Li content,to obtain a fast and effective method for estimating clay Li content.Finally,we developed a new method for rapid and nondestructive estimation of soil lithium content.We have obtained some important results from the study.Spectral resolution exerts a significant impact on model performance,and its reduction usually leads to a decline in model performance.For the full band,the models constructed with low-order derivatives were superior to those with high-order derivatives,and the best model was obtained at the 0.4-order derivative(coefficient of determination(R2)and relative predictive deviation(RPD)of 0.777 and 2.118,respectively).In the characteristic bands,the lower order is sensitive to the visible-near-infrared range,and the higher order is sensitive to the short-wave infrared range,and the model constructed with the higher-order derivatives outperforms the lower-order derivatives.In this study,the combination of FOD and Random Forest(RF)can significantly improve the model performance,with R2,Relative Root Mean Squared Error(RRMSE),and RPD being 0.849,1.526,and 2.574,respectively.Therefore,this research provides a theoretical basis and technical reference for imaging hyperspectral exploration of anomalous areas of clay-type Li resources. 展开更多
关键词 Hyperspectral remote sensing Fractional order Derivatives Random Forest Lithium Soil pollutant
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Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance 认领 引用
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作者 Si-Chan Li Shun-Zi Shao +7 位作者 Yu-Hang Zhang Yu Zhou Wen-Tao Shang Yuan Gao Qi-Bin He Qing-Long Guo Chuan-Yong Guo Xiao-Bo Zhang 《World Journal of Gastroenterology》 SCIE CAS 2026年第8期87-104,共18页
BACKGROUND Bortezomib(BTZ)is ineffective in gastric carcinoma(GC)due to lysosome-mediated resistance.Wogonin derivative V8 targets lysosomes.AIM To address the limited efficacy of BTZ in GC and explore whether wogonin... BACKGROUND Bortezomib(BTZ)is ineffective in gastric carcinoma(GC)due to lysosome-mediated resistance.Wogonin derivative V8 targets lysosomes.AIM To address the limited efficacy of BTZ in GC and explore whether wogonin derivative V8 enhances anti-GC effects by overcoming lysosome-mediated resistance.METHODS In vitro experiments used four human GC cell lines(MGC-803,BGC-823,AGS,and HGC-27)to assess cell viability(cell counting kit-8),lysosomal function(LysoSensor staining),autophagy(western blotting for light chain 3/p62),and drug synergy[combination index(CI)].Liquid chromatography/mass spectrometry measured intracellular BTZ concentration.Transcription factor EB(TFEB),a master regulator of lysosomal and autophagy genes,was investigated using small interfering RNA silencing and plasmid overexpression.In vivo efficacy/safety was tested in MGC-803 xenograft nude mice,and patient-derived tumor organoids(PDOs)validated clinical relevance.RESULTS BTZ was trapped in GC cell lysosomes,reducing its proteasome accessibility and inducing resistance;lysosome number correlated positively with the half-maximal inhibitory concentration of BTZ.V8 induced lysosomal damage/deacidification,increasing intracellular BTZ availability.V8+BTZ synergistically inhibited GC cell growth(CI<1),upregulated proteotoxic stress markers(ATF4,immunoglobulin heavy chain binding protein)and apoptotic mediators(cleaved caspase-3).TFEB knockdown enhanced V8+BTZ cytotoxicity,whereas its overexpression reduced cell death,indicating a protective role of TFEB in gastric cancer cells.In xenografts,V8+BTZ significantly reduced tumor volume/weight(P<0.01)without organ toxicity.PDOs showed enhanced sensitivity to V8+BTZ vs monotherapy.CONCLUSION Lysosomes mediate BTZ resistance in GC;V8 overcomes this by disrupting lysosomes,enabling BTZ to target proteasomes.V8+BTZ is a safe,effective strategy against GC. 展开更多
关键词 Gastric carcinoma Bortezomib Wogonin derivative V8 Lysosome Drug resistance Transcription factor EB Patient-derived organoids
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Piericidin F,a Novel Marine-Derived Piericidin Derivative,Degrades High-Risk HPV Oncoproteins E6/E7 by ROS-Dependent Ubiquitin Proteasome System and Induces Apoptosis in HeLa Cells 认领 引用
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作者 ZHANG Weiyi CHEN Yifan +5 位作者 CHANG Yimin HAN Xiaoning YANG Yufeng GU Qianqun LI Dehai LIU Ming 《Journal of Ocean University of China》 SCIE CAS CSCD 2026年第3期1133-1142,共10页
High-risk human papillomavirus(HPV)oncoproteins E6/E7 are essential for cellular carcinogenesis and malignant growth in HPV-positive cervical cancers,and these oncoproteins have been considered as promising targets fo... High-risk human papillomavirus(HPV)oncoproteins E6/E7 are essential for cellular carcinogenesis and malignant growth in HPV-positive cervical cancers,and these oncoproteins have been considered as promising targets for cervical cancer treatment.Here,for the first time,we report that piericidin F(PdF),a new piericidin derivative derived from marine Streptomyces,inhibits cell proliferation and induces cell apoptosis in HPV-positive human cervical cancer HeLa cells.Molecular mechanism studies showed that PdF disrupted the mitochondria function and inhibited the function of mitochondrial respiration chains complex I.Subsequently,this increased generation of ROS stimulates oncoproteins E6/E7 degradation via ubiquitin proteasome system.In short,we reveal a new mechanism underlying the anti-cancer activity of piericidin compounds by disrupting mitochondrial function and degrading oncoproteins E6/E7 in HPV-positive cervical cancers,and highlight that PdF has the potential to be a lead compound for therapeutic agents against HPV-positive cervical cancers. 展开更多
关键词 piericidin derivative ubiquitin proteasome system apoptosis reactive oxygen species E6/E7 cervical cancer
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Discovery of sulfonyl benzoic acid derivatives with joint TGR5-agonist and FXR-antagonist activity for myocardial ischemia/reperfusion injury protection 认领 引用
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作者 Xinyi Zhao Tianqi Chang +11 位作者 Xiang Wu Tongyu Huo Jing Peng Yameng Liu Dongfang Li Chao Wang Fan Yang Jiaxing Wang Xiaodong Dou Jinpeng Sun Ming Xu Ning Jiao 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2026年第6期3802-3827,共26页
TGR5 and FXR are key regulators of metabolic homeostasis and cardiovascular health.Since the cardioprotective capacity of TGR5 activation and FXR inhibition has been recognized,dual modulation of these targets offers ... TGR5 and FXR are key regulators of metabolic homeostasis and cardiovascular health.Since the cardioprotective capacity of TGR5 activation and FXR inhibition has been recognized,dual modulation of these targets offers a promising therapeutic strategy for myocardial ischemiaeperfusion injury.Herein,sulfonyl benzoic acid derivatives were identified as effective bidirectional modulators,with compound E6 emerging as a potent lead compound.E6 demonstrated robust dual-target activity,significantly preserving cardiomyocyte viability and attenuated reactive oxygen specie overproduction in hypoxiaeoxygenation models.Moreover,oral administration of E6 markedly reduced infarct size and improved cardiac contractile function after ischemiaeperfusion in vivo,without inducing gallbladder-related side effects.Notably,E6 demonstrated superior efficacy in restoring systolic function compared to mono-regulators.Transcriptomic analysis and subsequent validation studies suggested that its therapeutic effects are mediated through favorable modulation of inflammatory response,attenuation of apoptosis,and enhanced cardiomyocytes survival.Our findings underscore the therapeutic advantages of dual TGR5/FXR targeting and establish E6 as a promising bifunctional lead compound for the treatment of myocardial ischemiaeperfusion injury. 展开更多
关键词 TGR5 agoninst FXR antagonist Sulfonyl benzoic acid derivative Structure-activity relationship Myocardial ischemiaeperfusion injury Left ventricular ejection fraction Infarct size Cardioprotective mechanism
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Structural insights into pterocarpan reductases unveil a universal ring-opening mechanism in plant biosynthesis of 4-(furan-2-yl)phenol derivatives 认领 引用
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作者 Hongye Li Jianlin Zou +4 位作者 Meng Zhang Chunxue Zhao Yang-oujie Bao Yanfang Yang Min Ye 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2026年第6期3953-3962,共10页
Pterocarpans and isoflavans are important phytoalexins,and demonstrate significant benefits to human health.Pterocarpan reductases(PTRs)catalyze the conversion of pterocarpans to isoflavans,while the catalytic mechani... Pterocarpans and isoflavans are important phytoalexins,and demonstrate significant benefits to human health.Pterocarpan reductases(PTRs)catalyze the conversion of pterocarpans to isoflavans,while the catalytic mechanism remains unknown.Herein,we report six PTRs(GuPTR1-6)from Glycyrrhiza uralensis,together with the first PTR crystal structure(GuPTR1/(−)-medicarpin/NADP+,1.8Å).Structural analysis and mutagenesis reveal that a lysine-mediated deprotonation of the 7-OH group triggers C‒O bond cleavage of pterocarpans in the furan ring-opening reactions.This mechanism also applies to similar ring-opening enzymatic reactions.Through ancestral sequence reconstruction,we obtained a multifunctional reductase N0,which could accept different types of 4-(furan-2-yl)phenol derivatives as substrates.This study not only unveils the catalytic mechanisms of PTRs,but also provides a powerful enzymatic tool for the synthesis of bioactive isoflavans. 展开更多
关键词 Pterocarpan reductase Catalytic mechanisms Crystal structure Glycyrrhiza uralensis 4-(Furan-2-yl)phenol derivatives Ancestral sequence reconstruction C-O bond cleavage
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A NIR and ratiometric fluorescent probe for quantitative detection of SO2 derivatives in Chinese medicinal materials and bioimaging in vivo 认领 引用 被引量：1
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作者 Meitong Wu Ke Wu +7 位作者 Shumin Feng Li Xu Mi Lei Jianmei Chen Shuang Li Mian Qin Dahui Liu Guoqiang Feng 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期434-439,共6页
Sulfur dioxide(SO2) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the q... Sulfur dioxide(SO2) and its derivatives have been recognized as harmful environmental pollutants.However,they are often produced during the processing of traditional Chinese medicines,potentially compromising the quality of these medicinal materials and contributing to various health issues.Due to a lack of effective monitoring and imaging tools,the physiological effects of excessive SO2 residues in traditional Chinese medicine remain unclear.Therefore,developing a rapid and effective tool for detecting SO2 is crucial for understanding its metabolic pathways and effects in vivo.In this study,we developed a near infrared(NIR) and ratiometric fluorescent probe,NIR-RS,which exhibits high sensitivity,selectivity,and rapid response for SO2 detection.Notably,NIR-RS accurately quantifies SO2 contents in Pinelliae rhizoma(P.rhizoma) samples,with recovery rates from 98.46 % to 102.40 %,and relative standard deviations(RSDs)< 5.0 %.For bioimaging applications,NIR-RS has low cytotoxicity and good mitochondrial-targeting ability,making it suitable for imaging exogenous and endogenous SO2 in mitochondria.Additionally,NIR-RS was successfully applied to image SO2 content of P.rhizoma samples within cells,revealing that high SO2 residue elevated mitochondria adenosine triphosphate(ATP) content,these findings reveal that P.rhizoma with excessive SO2 can affect the organism's growth mechanisms through alterations in ATP pathways.In vivo,SO2 was found to predominantly accumulate in the liver following gavage with P.rhizoma solution,with accumulation levels increasing in proportion to SO2 residue concentration.High SO2 concentrations in P.rhizoma can cause pulmonary fibrosis and gastric mucosal damage.This work provides a valuable tool for regulating SO2 content in P.rhizoma and may help researcher better understand the metabolism of SO2 derivatives and explore their physiological roles in biological systems. 展开更多
关键词 Fluorescent probe SO2derivatives metabolism Quantitative analysis Pinelliae rhizoma Fluorescent imaging
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Research progress of 3-n-butylphthalide and its derivatives in combating cerebral ischemia 认领 引用
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作者 Hongwei Zheng Yangyang Jiang +7 位作者 Kai Wang Xiao Liu Zihan Jia Xing Su Yanan Zhang Yihua Zhang Zhangjian Huang Yong Ling 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期13-22,共10页
Ischemic stroke(IS)presents a major threat to human life and health due to its high disability and mortality rates.3-n-Butylphthalide(NBP),derived from celery seeds of the Apiaceae family native to the Mediterranean r... Ischemic stroke(IS)presents a major threat to human life and health due to its high disability and mortality rates.3-n-Butylphthalide(NBP),derived from celery seeds of the Apiaceae family native to the Mediterranean region,was first introduced in China for acute IS treatment in 2004.NBP demonstrates multiple therapeutic actions,including reconstruction of microcirculation in the cerebral ischemia area,inhibition of platelet aggregation,reduction of cerebral infarction volume,maintenance of blood-brain barrier(BBB)integrity,and enhancement of cerebral blood perfusion.However,its overall efficacy remains moderate,limited by poor water solubility and low bioavailability,which constrains its clinical application.To address these limitations,researchers have actively pursued the development of NBP derivatives and analogs,achieving notable progress.These efforts,including substituent introduction,ring opening derivatization,esterification,and atom substitution,have generated diverse NBP derivatives.Several of these derivatives have advanced to clinical studies.Specifically,potassium 2-(1-hydroxypentyl)-benzoate(PHPB),brozopentyl sodium(BZP),and XY-03-EA(ZONK1103)have reached phase II clinical trials,while(S)-2-(1-acetoxypentyl)benzoic acid L-arginine salt(AAPB)has received clinical trial approval for 2024.This review examines the structural modification and optimization of NBP over the past two decades from a medicinal chemistry perspective,aiming to facilitate the development of superior derivatives and advance cerebral ischemia treatment. 展开更多
关键词 Ischemic stroke 3-n-Butylphthalide Derivatives Structural modification Cerebral ischemia
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Panunoids A-D,four new prenylhydroquinone derivatives isolated from the fungus Panus rudis 认领 引用
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作者 Yun Liu Jian-Qiang Zhao +3 位作者 Yan-Long Yang Han-Bing Yuan Yan-Ming Wang Jun Yuan 《Natural Products and Bioprospecting》 CSCD 2026年第1期148-159,共12页
A chemical constituent study on the fermented rice substrate of basidiomycetous fungus Panus rudis led to the iso-lation of four previously undescribed prenylhydroquinone derivatives compounds(1-4)and eight known com-... A chemical constituent study on the fermented rice substrate of basidiomycetous fungus Panus rudis led to the iso-lation of four previously undescribed prenylhydroquinone derivatives compounds(1-4)and eight known com-pounds(5-12).Among them,compound 3 featured a rare benzothiazole derivative with hydroxy substituted 3-methyl-1-butenyl substitution on the benzene ring,and the absolute configurations of 7 and 12 were elucidated as unreported ones.Their structures were identified by the interpretation of 1D and 2D NMR spectroscopy,HRESIMS data,X-ray single-crystal diffraction,and comparison of calculated and experimental ECD spectra.The plausible biosynthetic pathways for 1-7 are proposed.Cytotoxicity evaluation was conducted on 1 and 3-12 against two cancer cell lines(A-549 and HepG2).The results demonstrated that 1,3-6,8,9,and 12 exhibited weak cytotoxicity against both two cell lines.Among them,8 and 12 showed dose-dependent inhibitory effects,and their IC50 values at 72 h were obtained. 展开更多
关键词 Panus rudis Solid-state fermentation Benzothiazole derivatives Cytotoxicity
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Asymmetric catalysis for the synthesis of planar chiral ferrocene derivatives 认领 引用
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作者 Haitao Liu Youlin Deng +2 位作者 Dan Ling Lingzhu Chen Zhichao Jin 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期180-190,共11页
The asymmetric catalytic synthesis of planar chiral ferrocene derivatives has received dramatic attention in recent years.Transition metal-catalyzed asymmetric cross-coupling reactions and C–H functionalization react... The asymmetric catalytic synthesis of planar chiral ferrocene derivatives has received dramatic attention in recent years.Transition metal-catalyzed asymmetric cross-coupling reactions and C–H functionalization reactions have played significant roles in the stereoselective construction of planar chiral ferrocene derivatives.Transition metals such as copper,palladium,rhodium,iridium,gold,and platinum have been adopted as the effective catalysts in combination with various chiral ligands to achieve satisfactory yields and stereoselectivity.Organic catalysts have also shown great potential in the synthesis of planar chiral ferrocenes.Chiral amines and N-heterocyclic carbenes(NHCs)have been the key catalysts for facile access to multi-functional ferrocene derivatives.Some of the planar chiral ferrocene molecules obtained from the above methods have demonstrated promising applications in the development of novel ligands for asymmetric synthesis and pesticides for plant protection.This review provides an overview on the key progresses in the catalytic synthesis of planar chiral ferrocene derivatives using transition metal catalysts and organic catalysts.The merits,challenges and potential directions in the future development within this highly active research field are also discussed at the end of this review. 展开更多
关键词 Ferrocene derivatives Planar chirality Asymmetric catalysis Desymmetrization Kinetic resolution
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A geometric algorithm for orbital dynamics based on Lie derivative 认领 引用
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作者 Yuhan SONG Shixing LIU +1 位作者 Wenan JIANG Yongxin GUO 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2026年第5期1157-1176,共20页
Orbital dynamics is a fundamental problem in celestial mechanics,yet its governing equations are characterized by irrational terms and denominator-type nonlinearities.Traditional numerical methods,which are locally di... Orbital dynamics is a fundamental problem in celestial mechanics,yet its governing equations are characterized by irrational terms and denominator-type nonlinearities.Traditional numerical methods,which are locally discrete,may lead to ambiguities near singularities(e.g.,x=y=z=0),thereby limiting the numerical stability and accuracy.To address these challenges,we propose a Lie derivative algorithm that constructs discrete iterative schemes based on the Lie series expansion.Unlike local schemes,this approach discretizes the vector field in a global manner,effectively avoiding singular inconsistencies while ensuring stable long-term integration.Numerical experiments demonstrate that,when compared with a high-accuracy reference solution under uniform step-size settings,the proposed approach not only achieves higher accuracy but also improves computational efficiency by up to 47%in the two-body problem and 67%in the circular restricted three-body problem,relative to classical second-order schemes.These results indicate that the Lie derivative algorithm provides an efficient and practical alternative for high-precision orbital dynamics computations. 展开更多
关键词 geometric numerical algorithm Lie derivative high efficiency three-body problem
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A benzoquinone derivative-mediated decoupled direct seawater electrolysis for separated hydrogen production 认领 引用
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作者 Shujing He Hanyu Jiang +9 位作者 Mengxin Li Yitao Xu Yiting Yang Liangyu Zhu Zhiyu Zhao Wenchuan Jiang Yifan Wu Zhejun Pan Cheng Lan Tao Liu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期772-781,I0019,共10页
Harvesting seawater for hydrogen production is essential to scale green hydrogen.However,the complex seawater matrix hampers direct electrolysis through catalyst deactivation and undermines compatibility with intermit... Harvesting seawater for hydrogen production is essential to scale green hydrogen.However,the complex seawater matrix hampers direct electrolysis through catalyst deactivation and undermines compatibility with intermittent renewables.Here,we develop a benzoquinone-derived redox-mediator(RM)strategy using 2,5-dihydroxy-1,4-benzoquinone(DHBQ)to decouple hydrogen and oxygen evolution in time and space.RM oxidation is paired with the hydrogen evolution reaction(HER),and RM reduction with the oxygen evolution reaction(OER),mitigating chloride-induced side reactions and corrosion hazards.DHBQ exhibits high solubility,excellent redox reversibility,and cycling stability in alkaline freshwater,simulated seawater,and natural seawater.At a current density of 100 m A cm-2,the DHBQ-mediated decoupled direct seawater electrolysis system operates at 1.72 V and remains stable for over 200 h across multiple current densities.This work provides new insights and a valuable route to decoupled H2/O2production in seawater and improves compatibility with intermittent renewable power. 展开更多
关键词 Decoupled direct seawater electrolysis Redox mediator Green hydrogen production Benzoquinone derivative Electrochemical engineering
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Electrochromic Devices with High Stability from Colorless to Green Conversion Based on Viologen Derivatives 认领 引用
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作者 PENG Yuyi QIAN Chao +3 位作者 WANG Peng GUO Xu JIANG Chuanyu LIU Ping 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第1期258-267,共10页
Two viologen derivatives containing fluorine substituent(F)with an asymmetric structures,1,1'-bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]dihexafluorophosphate(DFPV)and 1-benzyl-1'-(4-(trifluoromethyl)... Two viologen derivatives containing fluorine substituent(F)with an asymmetric structures,1,1'-bis(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]dihexafluorophosphate(DFPV)and 1-benzyl-1'-(4-(trifluoromethyl)phenyl)-[4,4'-bipyridine]di-hexafluorophosphate(Bn-FPV),were synthesized.These viologen derivatives as active materials were used to assemble both flexible and rigid electrochromic devices(ECDs).ECDs based on DFPV exhibited reversible color change from colorless to deep green and ECDs based on Bn-FPV exhibited reversible color change from colorless to blue-green within applied voltage.It was found that the devices based on DFPV showed cycle stability,which could still maintain more than 90% after 1000 cycles.In addition,the modulation rate of the device to the solar irradiance is also calculated to characterize its application potential in smart windows.Among them,the rigid device(R-DFPV)based on the DFPV has a large solar irradiance modulation rate of 54.66%,which has the potential to be used as smart windows. 展开更多
关键词 viologen derivatives electrochromic material flexible electrochromic devices rigid electrochromic device smart windows
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Experimental Validation on a Real-World Truss Structure of a Damage Localization Method Based on Mode Shape Derivatives 认领 引用
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作者 Giada Faraco Andrea Vincenzo De Nunzio +1 位作者 Nicola Ivan Giannoccaro Arcangelo Messina 《Structural Durability & Health Monitoring》 EI 2026年第2期23-38,共16页
Damage detection and localization analysis have gained increasing importance over the years,due to the growing number of catastrophic events and the associated risks that small,undetected cracks in structures may evol... Damage detection and localization analysis have gained increasing importance over the years,due to the growing number of catastrophic events and the associated risks that small,undetected cracks in structures may evolve into severe failures if not identified in time.In this context,vibration-based methods have been extensively investigated for structural damage detection.Among them,one of the most widely used approaches since its introduction is the curvature method.It has been successfully employed in numerous studies,consistently providing reliable results.However,the use of second-order or higher-order derivatives can be challenging when dealing with experimental data,as these are highly sensitive tomeasurement noise.Conversely,using the first derivative may simplify the analysis while maintaining robustness.Therefore,the present work introduces and experimentally demonstrates an extension of the curvature-based approach,focusing on the integration of the first derivative for damage localization.In particular,both methods based on the use of the second and first derivatives were applied to detect their capability in detecting and localizing the damage.This was tested on a slender truss structure,with induced damages at different locations,equal to just 1.069%of the structure volume.The results,obtained from this real-world case study,show that for certain structures,like slender ones,the use of the first derivative can achieve equal or even superior damage detection performance compared to the traditional second derivative method.Specifically,the comparison was evaluated based on the accuracy in localizing the damage with the twomethods,both froma visual and quantitative point of view,since a deviation index δ was also introduced. 展开更多
关键词 Damage localization mode shapes mode shape derivatives curvature method structural health monitoring
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A Deterministic and Stochastic Fractional-Order Model for Computer Virus Propagation with Caputo-Fabrizio Derivative:Analysis,Numerics,and Dynamics 认领 引用
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作者 Najat Almutairi Mohammed Messaoudi +1 位作者 Faisal Muteb K.Almalki Sayed Saber 《Computer Modeling in Engineering & Sciences》 SCIE EI 2026年第3期806-843,共38页
This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four... This paper introduces a novel fractional-order model based on the Caputo-Fabrizio(CF)derivative for analyzing computer virus propagation in networked environments.The model partitions the computer population into four compartments:susceptible,latently infected,breaking-out,and antivirus-capable systems.By employing the CF derivative—which uses a nonsingular exponential kernel—the framework effectively captures memory-dependent and nonlocal characteristics intrinsic to cyber systems,aspects inadequately represented by traditional integer-order models.Under Lipschitz continuity and boundedness assumptions,the existence and uniqueness of solutions are rigorously established via fixed-point theory.We develop a tailored two-step Adams-Bashforth numerical scheme for the CF framework and prove its second-order accuracy.Extensive numerical simulations across various fractional orders reveal that memory effects significantly influence virus transmission and control dynamics;smaller fractional orders produce more pronounced memory effects,delaying both infection spread and antivirus activation.Further theoretical analysis,including Hyers-Ulam stability and sensitivity assessments,reinforces the model’s robustness and identifies key parameters governing virus dynamics.The study also extends the framework to incorporate stochastic effects through a stochastic CF formulation.These results underscore fractional-order modeling as a powerful analytical tool for developing robust and effective cybersecurity strategies. 展开更多
关键词 Caputo-Fabrizio derivative fractional-order computer virus model stochastic fractional dynamics Adams-Bashforth scheme Hyers-Ulam stability sensitivity analysis cyber-epidemiology memory effects nonsingular kernel
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Pyrazino[2,3-f][1,10]phenanthroline Derivatives as Photoredox Catalysts for Photoinduced Organocatalyzed Atom Transfer Radical Polymerization(O-ATRP)at ppm-Level Loading 认领 引用
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作者 Wen-Zhe Xu Wan-Chao Hu +1 位作者 Bei Liu Chang-Li Lü 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第3期664-674,I0009,共11页
Organocatalyzed atom transfer radical polymerization(O-ATRP)is a pivotal technique for the synthesis of polymers with well-defined structures that are devoid of metallic residues.A major challenge in this area is the ... Organocatalyzed atom transfer radical polymerization(O-ATRP)is a pivotal technique for the synthesis of polymers with well-defined structures that are devoid of metallic residues.A major challenge in this area is the reduction of catalyst loading while maintaining precise control over polymer architecture and properties.Herein,we systematically evaluate the efficacy of six pyrazino[2,3-f][1,10]phenanthroline(pyzPhen)-based photoredox catalysts in photoinduced O-ATRP.Experimental results indicate that the introduction of various substituents markedly influences the photophysical properties and redox behavior of the catalysts,thereby resulting in differing catalytic efficiencies in the O-ATRP of methyl methacrylate(MMA).Following additional optimization,two highly efficient O-ATRP photocatalysts capable of exhibiting thermally activated delayed fluorescence(TADF)were successfully identified.Under visible light irradiation,TADF catalysts effectively mediated the controlled polymerization of MMA at a low loading level of 50 ppm,particularly when used in conjunction with the initiator DBMM.The catalytic systems demonstrate excellent temporal control,broad monomer applicability,and favorable compatibility with various initiators and solvent systems.This work offers new insights into the development of efficient,low-catalyst-loading,metal-free ATRP systems. 展开更多
关键词 Organocatalyzedatom transfer radical polymerization(O-ATRP) Photoredox catalysts Pyrazino[2,3-f][1,10]phenanthroline derivatives Thermally activated delayed fluorescence(TADF) Low catalyst loading
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Anodic Self-Electrochemiluminescence of Carboxyl-Functionalized Tetraphenylethylene Derivatives for SOD2 Detection 认领 引用
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作者 Zuoxun Xie Bangxiang Liu +6 位作者 Runying He Qiang Yu Xiurong Ma Yunming Liu Xinye Cao Qiue Cao Liyan Zheng 《Aggregate》 EI CAS CSCD 2026年第6期56-68,共13页
The self-electroluminescent(self-ECL)behaviors of tetraphenylethylene carboxyl derivatives(TPED-(COOH)x)during the anodic process are first reported in this work.This study establishes a genuine co-reactant-free se... The self-electroluminescent(self-ECL)behaviors of tetraphenylethylene carboxyl derivatives(TPED-(COOH)x)during the anodic process are first reported in this work.This study establishes a genuine co-reactant-free self-ECL system driven by electrogenerated radical disproportionation,which is mechanistically distinct from classic annihilation and co-reactant-mediated ECL pathways.The self-ECL mechanism involves the disproportionation of electrogenerated TPED∙+-(COO−)x radicals to directly populate a charge-transfer excited state,which then decays radiatively.The results of the structure-activity analysis indicate that the electronic structure(determined by the conjugation length and substitution position)and intermolecular packing interactions are more important than either the aggregation-induced emission property or the oxidation potential for self-ECL.Furthermore,numerous controlled experiments have confirmed that the carboxyl group is essential for triggering self-ECL and this strategy can be extended to other AIE molecules.Notably,4″,4″″′,4″″″″,4″″″″″′-(ethene-1,1,2,2-tetrayl)tetrakis([1,1′:4′,1″-terphenyl]-4-carboxylic acid)(H4 TCTPE)achieved a high self-ECL efficiency of up to 411%(relative to Ru(bpy)32+,ΦECL=5%).Under optimal experimental conditions,an immunosensor for superoxide dismutase 2(SOD2)was constructed based on H4 TCTPE,with a linear range of 0.01–100 ng/mL,a detection limit of 7.9 pg/mL,excellent selectivity,reproducibility,and stability,and was successfully applied to serum analysis.This work provides a theoretical basis and design principles for the development of next-generation self-ECL luminophores. 展开更多
关键词 disproportionation SOD2 self-electrochemiluminescence tetraphenylethylene carboxyl derivatives
Design,synthesis and anti-tumor evaluation of plinabulin derivatives 认领 引用
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作者 HUANG Shijie TANG Ya +4 位作者 MA Qinbo ZHANG Zixuan CAO Yating JIANG Tao QIU Peiju 《中国海洋药物》 CAS CSCD 2026年第2期36-42,共7页
Objective To modify the 4-position of the B ring of Plinabulin,a total of 7 novel compounds were synthesized,and their antitumor activity was evaluated.Methods The cytotoxic activities of all derivatives against cance... Objective To modify the 4-position of the B ring of Plinabulin,a total of 7 novel compounds were synthesized,and their antitumor activity was evaluated.Methods The cytotoxic activities of all derivatives against cancer cell lines were evaluated using the MTT assay,and the cell cycle arrest and apoptosis promotion effects were evaluated using flow cytometry.Tubulin destructive effects were evaluated using Immunofluorescence experiments.Results Among these derivatives,P6 exerted comparable inhibitory effect against tested cell lines.Immunofluorescence assay showed that P6 at a concentration of 180 nmol/L significantly disturbed tubulin structure.Flow cytometry analysis demonstrated that P6 induced obvious G2/M cell cycle arrest and apoptosis in a dose-dependent manner.This study developed a potential candidate for cancer treatment as antimicrotubule agent. 展开更多
关键词 plinabulin derivatives antitumor β-tubulin cell cycle arrest apoptosis
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UGT74B5-mediated glucosylation at ortho hydroxyl groups of benzoic acid derivatives regulating plant immunity to anthracnose in tea plants 认领 引用 被引量：6
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作者 Caiyun Li Feixue Wu +7 位作者 Lei Yang Nana Liu Xinfu Zhang Fengfeng Qu Liping Gao Tao Xia Lei Zhao Peiqiang Wang 《Horticulture Research》 SCIE CSCD 2025年第4期269-282,共14页
Benzoates,particularly salicylic acid(SA)and its derivatives,play critical roles in plant immune responses and basal defense through hydroxylation and glycosylation.Anthracnose is one of the most common and devastatin... Benzoates,particularly salicylic acid(SA)and its derivatives,play critical roles in plant immune responses and basal defense through hydroxylation and glycosylation.Anthracnose is one of the most common and devastating diseases in tea plants(Camellia sinensis).However,the role of SA and its derivatives in tea plant immunity and resistance to anthracnose remains largely unexplored.In the present study,we identified and characterized a glycosyltransferase,CsUGT74B5,which was significantly downregulated in tea seedlings upon anthracnose infection.CsUGT74B5 was preferentially expressed in mature leaves and stem,and responded rapidly to exogenous SA treatment.Phylogenetic analysis suggested CsUGT74B5 might possess the catalytic activity toward benzoates.Enzymatic assays and molecular docking demonstrated recombinant CsUGT74B5 specifically glycosylated at the ortho hydroxyl groups of SA and 2,6-dihydroxybenzoic acid(2,6-DHBA),but did not glycosylate 2,3-DHBA,2,5-DHBA,or other substrates in vitro.Overexpression of CsUGT74B5 in Arabidopsis thaliana and tobacco(Nicotiana tabacum)reduced SA level while promoting the accumulation of SA 2-O-β-D-glucoside(SAG),further validating the in vivo function of CsUGT74B5.Moreover,transient overexpression of CsUGT74B5 in two tea plant cultivars increased their sensitivity to anthracnose and accelerated lesion development,which was attributed to decreased SA levels.Overall,our finding demonstrated that CsUGT74B5-mediated biosynthesis of SAG regulated tea plant immunity against anthracnose by fine-tuning free SA levels,providing new progress into the immunity response of tea plants. 展开更多
关键词 anthracnose glycosylation benzoic acid derivatives salicylic acid immunity UGT B basal defense tea plants
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Comprehensive review of synthesis strategies and performance enhancement of metal-organic frameworks and their derivatives for photocatalytic applications 认领 引用 被引量：1
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作者 Huihua Luo Lianqing Yu +5 位作者 Chong Liu Nannan Chen Kehui Xue Wendi Liu Haifeng Zhu Yaping Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第4期408-439,共32页
Energy conversion and environmental pollution present significant challenges that necessitate the development of materials with optimal characteristics for effective applications in solar energy-driven photocatalysis.... Energy conversion and environmental pollution present significant challenges that necessitate the development of materials with optimal characteristics for effective applications in solar energy-driven photocatalysis.Metal-organic frameworks(MOFs)serve as excellent platforms for the development of various MOF-derived materials,which have garnered extensive attention due to their unique structural features,high crystallinity,large surface areas,diverse morphologies,adjustable dimensions,tunable textural characteristics,and inherent catalytic activity.However,the sluggish charge kinetics and poor stability of MOFs and MOF-derived photocatalysts restrict their photocatalytic activity,thereby limiting their applications in the field of photocatalysis.Consequently,substantial research efforts have been directed toward maximizing the advantages of these intriguing materials while addressing their shortcomings.This review provides a comprehensive summary and analysis of various synthesis strategies of MOFs and their derivatives.Effective modification strategies to enhance the performance of these novel materials are also summarized.This review systematically explores the current advancements in the application of MOFs and their derivatives for photocatalytic water splitting,photocatalytic CO2reduction,and environmental water pollution treatment.Finally,it discusses the challenges and future prospects of MOFs and MOF-derived materials in photocatalytic applications.Researchers should systematically optimize synthetic strategies and functionalize MOFs and their derivatives to enhance their application in energy conversion and environmental pollution control,thereby underscoring their extensive potential.Future research will increasingly concentrate on the intelligent design and functionalization of MOFs to attain superior catalytic performance and tackle the urgent energy and environmental challenges confronting the world. 展开更多
关键词 Metal-organic frameworks Derivatives Energy convention Environmental pollution
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Novel Bipolar Hosts for Solution-processable Green Phosphorescent OLEDs Based on Tetrasubstituted Carbazole Derivatives 认领 引用 被引量：2
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作者 HUANG Hong ZHANG Youming +2 位作者 HUA Tao LI Nengquan XIE Guohua 《发光学报》 EI CAS CSCD 北大核心 2025年第11期1971-1979,共9页
Two tetrasubstituted carbazole derivatives TBICz and TOXDCz have been designed and synthesized,which possess the twist skeletons and exhibit excellent thermal and morphological stabilities.Utilizing these novel compou... Two tetrasubstituted carbazole derivatives TBICz and TOXDCz have been designed and synthesized,which possess the twist skeletons and exhibit excellent thermal and morphological stabilities.Utilizing these novel compounds as host material,high efficiency solution-processed green phosphorescent organic light-emitting diodes(PhOLEDs)have been achieved.The high triplet energies of TBICz and TOXDCz ensure efficient energy transfer from the host to the phosphor and triplet exciton confinement on the phosphor.Solution-processable green phospho⁃rescent devices employing Ir(ppy)3 as guest and the two tetrasubstituted carbazole derivatives as hosts exhibit high ef⁃ficiencies.The best EL performance is achieved for the TBICz-based device,with a maximum current efficiency of 27.3 cd/A,a maximum power efficiency of 15.9 lm/W,and a maximum external quantum efficiency of 7.8%,which provides more host material options for solution-processed OLEDs. 展开更多
关键词 tetrasubstituted carbazole derivatives green phosphorescent organic light-emitting diodes solution-pro⁃cessed bipolar host
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