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Magnetic resonance tractography of the cervical spine:A rapid diffusion tensor imaging protocol to serve as a clinical evaluation tool 认领 引用 被引量：1
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作者 Emilio P Supsupin Alejandro Serrano +7 位作者 Christopher Louviere Luke Pearson Mauricio Hernandez Vashisht Sekar Aboubakr Amer Ulas Cikla Mayur Virarkar Kazim Z Gumus 《World Journal of Radiology》 2025年第9期92-104,共13页
BACKGROUND Spinal cord injury can lead to long-term disability,but current imaging methods are limited in predicting outcomes.Rapid diffusion tensor imaging(DTI)has shown promise,yet its clinical utility remains under... BACKGROUND Spinal cord injury can lead to long-term disability,but current imaging methods are limited in predicting outcomes.Rapid diffusion tensor imaging(DTI)has shown promise,yet its clinical utility remains underexplored.AIM To evaluate the potential applications of a short DTI sequence,incorporated into a cervical spine magnetic resonance imaging(MRI)protocol,for characterizing a range of symptomatic spinal cord pathologies.We propose that cervical spine tractography can provide essential diagnostic information beyond what is currently available from conventional MRI.METHODS We utilized a quick DTI sequence to create tractography models of the cervical spinal cord in four patients with distinct pathologies of various etiologies:Cord contusion,metastasis,myelopathy,and multiple sclerosis.We used DSI Studio software for post-processing of tractography cases.Fiber tract findings for each pathology case were compared to five control cases from the same scanner by looking for individual differences in white matter tract integrity based on the fractional anisotropy(FA)and mean diffusivity(MD)of the regions of interest from controls.These correlated with clinical presentations and conventional MRI findings.RESULTS Control cases showed consistent and intact tract patterns with stable FA and MD values.In pathological cases,abnormalities in fiber orientation and tract continuity correlated with clinical symptoms and lesion locations.CONCLUSION The tractography models can provide additional information on white matter disruption that was not discernible on standard MRI sequences.However,its clinical use remains limited due to the need for specialized imaging protocols and complex post-processing,restricting its use to mostly academic settings. 展开更多
关键词 Cervical spinal cord Diffusion tensor imaging Tractography Fractional anisotropy Mean diffusivity
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Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction 认领 引用 被引量：33
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作者 Xiao-na Wu Tao Zhang +9 位作者 Jun Wang Xiao-yan Liu Zhen-sheng Li Wei Xiang Wei-qing Du Hong-jun Yang Tie-gen Xiong Wen-ting Deng Kai-run Peng Su-yue Pan 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第7期1115-1121,共7页
Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether naajor ozonated autohelnotherapy affects remote in）ury remains po... Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether naajor ozonated autohelnotherapy affects remote in）ury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups. Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy （47 mg/L, 100 mL ozone） for 10 ± 2 days. Patients in the control group received medical treatment only. National Institutes of Health Stroke Scale score, modified Rankin scale score, and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased, brain function improved, clinical efficiency significantly increased, and no obvious adverse reactions detected in the ozone treatment group compared with the control group. These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing re,note injury, and additionally, exhibits high safety. 展开更多
关键词 nerve regeneration ozone cerebral infarction magnetic resonance diffusion tensor imaging anisotropy internal capsule whitematter corticospinal tract cerebral peduncle neural regeneration
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Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction 认领 引用 被引量：21
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作者 Ruiman Xie Min Fang +5 位作者 Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第12期900-905,共6页
To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffus... To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction, 23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction. The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days. The diffusion coefficient remained unchanged. Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. 展开更多
关键词 corticospinal tracts Wallerian degeneration fractional anisotropy diffusion tensor imaging neuroimaging neural regeneration
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Optic radiation injury in patients with aneurismal subarachnoid hemorrhage: a preliminary diffusion tensor imaging report 认领 引用 被引量：10
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作者 Sung Ho Jang Chul Hoon Chang +2 位作者 Young Jin Jung Seong Ho Kim Jeong Pyo Seo 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第3期563-566,共4页
Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage（SAH）. Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study,we ... Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage（SAH）. Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study,we investigated the diffusion tensor imaging （DTI） finding of the optic radiation in patients with SAH followingrupture of a cerebral artery aneurysm. We recruited 21 patients with aneurismal SAH （12 males, 9 females, mean age, 52.67 years; range, 41–68 years） who showed no definite lesion along the visual pathway.Twenty-one age-and sex-matched normal control subjects were also recruited. DTI data were acquired at an average of 5.9 weeks （range： 3–12 weeks） after onset and reconstruction of the optic radiation was performed using DTI-Studio software. The fractional anisotropy value, apparent diffusion coefficient value,and fiber number of the optic radiation were measured. The fractional anisotropy value of the optic radiation was significantly decreased, and the apparent diffusion coefficient value was significantly increased, in patients with aneurismal SAH than in normal control subjects. However, there was no significant difference in the fiber number of the optic radiation between patients with aneurismal SAH and normal control subjects. The decrement of fractional anisotropy value and increment of apparent diffusion coefficient value of the optic radiation in patients with aneurismal SAH suggest optic radiation injury. Therefore, we recommend a thorough evaluation for optic radiation injury in patient with aneurismal SAH. 展开更多
关键词 nerve regeneration diffusion tensor imaging optic radiation subarachnoid hemorrhage visual field defect neural regeneration
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Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging 认领 引用 被引量：14
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作者 Qiu-Juan Zhang Dong Wang +2 位作者 Zhi-Lan Bai Bai-Chao Ren Xiao-Hui Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期975-979,共5页
AIM: To evaluate the value of quantitative diffusion tensor imaging (DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle -closure glaucoma (PA... AIM: To evaluate the value of quantitative diffusion tensor imaging (DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle -closure glaucoma (PACG) by using high -field magnetic resonance (MR) imaging (3T). METHODS: Twenty patients with bilateral chronic PACG and twenty age - and sex matched disease -free control subjects were enrolled. Conventional MRI and DTI were performed on all subjects using 3T MR scanner. Mean diffusivity (MD), fractional anisotropy (FA), axial diffusivities (AD) and radial diffusivities (RD) of each optic nerve and each optic radiation were measured by using post -processing software of DTI studio 2.3, and then compared between left eyes and right eyes and between patients group and control group. The pairedsample t- test were used. RESULTS: There was no abnormality in the shape and signal intensity of the optic nerves and optic radiations in patients group and control group on the conventional MRI. No significant differences were observed in the FA, MD, AD and RD between the right and left optic nerves and optic radiations within patients group and control group (P>0.05). The optic nerves and optic radiations of patients with chronic PACG, as compared with control subjects, had significantly higher MD, AD, RD and significantly lower FA (P<0.05). CONCLUSION: The diffusivity of optic nerves and optic radiations in chronic PACG group showed abnormal and diffusivity parameters could be used markers of axonal and myelin injury in glaucoma. 展开更多
关键词 primary angle-closure glaucoma chronic optic nerve and optic radiation diffusion tensor imaging magnetic resonance imaging
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Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury 认领 引用 被引量：8
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作者 Chang-Bin Liu De-Gang Yang +12 位作者 Qian-Ru Meng Da-Peng Li Ming-Liang Yang Wei Sun Wen-Hao Zhang Chang Cai Liang-Jie Du Jun Li Feng Gao Yan Yu Xin Zhang Zhen-Tao Zuo Jian-Jun Li 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第5期877-886,共10页
Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the micros... Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the microstructure of nerve tissue and can quantify the pathological damage of spinal cord white matter and gray matter. In this study, a custom-designed spinal cord contusion-impactor was used to damage the T_（10） spinal cord of beagles. Diffusion tensor imaging was used to observe changes in the whole spinal cord, white matter, and gray matter, and the Texas Spinal Cord Injury Score was used to assess changes in neurological function at 3 hours, 24 hours, 6 weeks, and 12 weeks after injury. With time, fractional anisotropy values after spinal cord injury showed a downward trend, and the apparent diffusion coefficient, mean diffusivity, and radial diffusivity first decreased and then increased. The apparent diffusion-coefficient value was highly associated with the Texas Spinal Cord Injury Score for the whole spinal cord（R = 0.919, P = 0.027）, white matter（R = 0.932, P = 0.021）, and gray matter（R = 0.882, P = 0.048）. Additionally, the other parameters had almost no correlation with the score（P 〉 0.05）. In conclusion, the highest and most significant correlation between diffusion parameters and neurological function was the apparent diffusion-coefficient value for white matter, indicating that it could be used to predict the recovery of neurological function accurately after spinal cord injury. 展开更多
关键词 nerve regeneration spinal cord injury diffusion tensor imaging fractional anisotropy apparent diffusion coefficient white matter gray matter Texas Spinal Cord Injury Score beagles neural regeneration
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Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury 认领 引用 被引量：5
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作者 Wen-Zhu Wang Xu Liu +2 位作者 Zheng-Yi Yang Yi-Zheng Wang Hai-Tao Lu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第4期838-844,共7页
At present,predicting the severity of brain injury caused by global cerebral ischemiaeperfusion injury(GCI/RI)is a clinical problem.After such an injury,clinical indicators that can directly reflect neurological dysfu... At present,predicting the severity of brain injury caused by global cerebral ischemiaeperfusion injury(GCI/RI)is a clinical problem.After such an injury,clinical indicators that can directly reflect neurological dysfunction are lacking.The change in hippocampal microstructure is the key to memory formation and consolidation.Diffusion tensor imaging is a highly sensitive tool for visualizing injury to hippocampal microstructure.Although hippocampal microstructure,brain-derived neurotrophic factor(BDNF),and tropomyosin-related kinase B(Trk B)levels are closely related to nerve injury and the repair process after GCI/RI,whether these indicators can reflect the severity of such hippocampal injury remains unknown.To address this issue,we established rat models of GCI/RI using the four-vessel occlusion method.Diffusion tensor imaging parameters,BDNF,and Trk B levels were correlated with modified neurological severity scores.The results revealed that after GCI/RI,while neurological function was not related to BDNF and Trk B levels,it was related to hippocampal fractional anisotropy.These findings suggest that hippocampal fractional anisotropy can reflect the severity of hippocampal injury after global GCI/RI.The study was approved by the Institutional Animal Care and Use Committee of Capital Medical University,China(approval No.AEEI-2015-139)on November 9,2015. 展开更多
关键词 brain-derived neurotrophic factor diffusion tensor imaging fractional anisotropy value global cerebral ischemiaeperfusion injury hippocampus Trk B
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GRADING OF RABBIT SKELETAL MUSCLE TRAUMA BY DIFFUSION TENSOR IMAGING AND TRACTOGRAPHY ON MAGNETIC RESONANCE IMAGING 认领 引用 被引量：10
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作者 Hui Zeng Jun-hui Zheng +1 位作者 Jin-e Zhang Yan-hui Liu 《Chinese Medical Sciences Journal》 CAS 2006年第4期276-280,共5页
Objective To distinguish the edema, injury, or rupture in the traumatic skeletal muscle fiber in vivo using diffusion tensor imaging （DTI） and tractography on magnetic resonance imaging （MRI）. Methods The skeletal... Objective To distinguish the edema, injury, or rupture in the traumatic skeletal muscle fiber in vivo using diffusion tensor imaging （DTI） and tractography on magnetic resonance imaging （MRI）. Methods The skeletal muscle trauma models were made in 4 rabbits （ eight hindlimbs） by iron discus （ weight 1. 0 kg, diameter 6 cm） falling down vertically from 45 cm height to rabbits＇ thighs. Conventional sequences and two-dimensional （2D） diffusion-weighted （DW） spin-echo （SE） echo planar imaging （EPI） sequence with fat suppression （ b = 600 s/mm^2 ） were performed on 1.5T MRI scanner. The grading of edema, injury, and fiber rupture in the damaged muscle were made according to their histopathological views, which was consistent with the images. The mean apparent diffusion coefficient （ADC） values and fractional anisotropy （FA） values were measured from the region of interests （ROIs） of all groups on 2D DW images used for tractography. Analysis of variance test was performed to analyze all data. Results ADC values of the areas in normal muscle, edema muscle, injury muscle, and ruptured muscle were （6. 12±1.34 ） × 10^-3, （ 6.38±1.30 ） × 10^-3, （ 8.06±0. 97 ） × 10^-3, and （ 9. 57±0. 93 ） × 10^-3 mm^2/s, respectively. There was significant difference among groups （P 〈0. 001 ）, but no difference between edema muscle and normal muscle group （P 〉0. 05）. The FA values of normal muscle, edema muscle, injury muscle, and ruptured muscle were 0. 42±0. 12, 0. 36±0. 12, 0. 26±0. 09, 0. 12±0. 08, respectively, with a significant difference among groups （ P 〈 0. 001 ）. In the edema muscle, the tracking cross-fiber could be seen but it decreased slightly. In the injury muscle, the tracking fiber decreased markedly. In the ruptured muscle, the transverse-orientation tracking fiber vanished, yet some interrupted longitudinal-orientation tracking fiber could be found. Conclsion The edema, injury, and rupture of muscle fiber in rabbit damaged skeletal muscle can be verified according to the ADC and the FA on DTI and tractography. 展开更多
关键词 traumatic skeletal muscle grade diffusion tensor imaging tractography
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Magnetic resonance diffusion tensor imaging of optic nerve and optic radiation in healthy adults at 3T 认领 引用 被引量：6
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作者 Hong-Hong Sun Dong Wang +2 位作者 Qiu-Juan Zhang Zhi-Lan Bai Ping He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2013年第6期868-872,共5页
AIM:To investigate the diffusion characteristics of water of optic nerve and optic radiation in healthy adults and its related factors by diffusion tensor imaging（DTI）at3T.METHODS:A total of 107 healthy volunteers p... AIM:To investigate the diffusion characteristics of water of optic nerve and optic radiation in healthy adults and its related factors by diffusion tensor imaging（DTI）at3T.METHODS:A total of 107 healthy volunteers performed head conventional MRI and bilateral optic nerve and optic radiation DTI.The primary data of DTI was processed by post-processing software of DTI studio 2.3,obtaining fractional anisotropy value,mean diffusivity value,principal engine value,orthogonal engine value by measuring,and analyzed by the SPSS13.0 statistical software.RESULTS:The bilateral optic nerve and optic radiation fibers presented green color in directional encoded color（DEC）maps and presented high signal in fractional anisotropy（FA）maps.The FA value of the left optic nerve was 0.598±0.069 and the right was 0.593±0.065;the mean diffusivity（MD）value of the left optic nerve was（1.324±0.349）×10-3mm2/s and the right was（1.312±0.350）x10-3mm2/s;the principal engine value(λ?)of the left optic nerve was（2.297±0.522）×10-4mm2/s and the right was（2.277±0.526）×10-3mm2/s;the orthogonal engine value（λ⊥）of the left optic nerve was（0.838±0.285）×10-3mm2/s and the right was（0.830±0.280）×10-3mm2/s;the FA value of the left optic radiation was 0.636±0.057 and the right was0.628±0.056;the mean diffusivity（MD）value of the left optic radiation was（0.907±0.103）×10-3mm2/s and the right was（0.889±0.125）×10-3mm2/s;the principal eigenvalue(λⅡ)of the left optic radiation was（1.655±0.210）×10-3mm2/s and the right was（1.614±0.171）×10-3mn2/s;the orthogonal enginvalue（λ⊥）of the left optic radiation was（0.531±0.103）×10-3mm2/s and the right was（0.524±0.152）×10-3mm2/s.There was no obvious difference between the FA,MD,λ‖,λ⊥of the bilateral optic radiation and the bilateral optic nerve（P】0.05）and no obvious differencebetween male and female group.The FA,MO,λ‖,λ⊥of the bilateral optic radiation and the bilateral optic nerve had no obvious correlations to the age.CONCLUSION:DTI is sensitive to the optic nerve and radiation and the relevant DTI parameters of the optic nerve and radiation are established preliminarily in this study. 展开更多
关键词 magnetic resonance imaging diffusion tensor imaging optic nerve optic radiation fractional anisotropy mean diffusivity
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Magnetic resonance diffusion tensor imaging and diffusion tensor tractography of human visual pathway 认领 引用 被引量：9
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作者 Yan Zhang Si-Hai Wan +1 位作者 Gui-Jun Wu Xue-Lin Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2012年第4期452-458,共7页
AIM:To investigate the visual pathway in normal subjects and patients with lesion involved by diffusion tensor imaging(DTI)and diffusion tensor tractography(DTT).METHODS:Thirty normal volunteers,3 subjects with orbita... AIM:To investigate the visual pathway in normal subjects and patients with lesion involved by diffusion tensor imaging(DTI)and diffusion tensor tractography(DTT).METHODS:Thirty normal volunteers,3 subjects with orbital tumors involved the optic nerve(ON)and 33 subjects with occipital lobe tumors involved the optic radiation(OR)(10 gliomas,6 meningiomas and 17 cerebral metastases)undertook routine cranium magnetic resonance imaging(MRI),DTI and DTT.Visual pathway fibers were analyzed by DTI and DTT images.Test fractional anisotropy(FA)and mean diffusivity(MD)values in different part of the visual pathway.RESULTS:The whole visual pathway but optic chiasm manifested as hyperintensity in FA maps and homogenous green signal in the direction encoded color maps.The optic chiasm did not display clearly.There was no significant difference between the bilateral FA values and MD values of normal visual pathway but optic chiasm,which the FA values tested were much too low(all P>0.05).The ONs of subjects with orbital tumors were compressed and displaced.Only one subject had lower FA values and higher MD values.OR of 9 gliomas subjects were infiltrated,with displacement in 2 and disruption in 7 subjects.All OR in 6 meniongiomas subjects were displaced.OR in 17 cerebral metastases subjects all developed displacement while 7 of them had disruption also.CONCLUSION:MR-DTI is highly sensitive in manifesting visual pathway.Visual pathway can be analyzed quantitatively in FA and MD values.DTT supplies accurate three dimensional conformations of visual pathway.But optic chiasm's manifestation still needs to improve. 展开更多
关键词 visual pathway human diffusion tensor imaging diffusion tensor tractography
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Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects 认领 引用 被引量：5
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作者 Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir +3 位作者 Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha 《World Journal of Clinical Cases》 SCIE 2022年第24期8450-8462,共13页
Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological ba... Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain elusive.Enhanced relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in CSVD.Diffusion tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter damage.However,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical use.In this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals. 展开更多
关键词 Diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing Tractography
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Evaluation of mannitol effect in patients with acute hepatic failure and acute-on-chronic liver failure using conventional MRI,diffusion tensor imaging and in-vivo proton MR spectroscopy 认领 引用 被引量：3
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作者 Vivek A Saraswat Sona Saksena +5 位作者 Kavindra Nath Pranav Mandal Jitesh Singh M Albert Thomas Ramkishore S Rathore Rakesh K Gupta 《World Journal of Gastroenterology》 SCIE CAS 2008年第26期4168-4178,共11页
AIM： To evaluate the effect of an intravenous bolus of mannitol in altering brain metabolites, brain water content, brain parenchyma volume, cerebrospinal fluid （CSF） volume and clinical signs in controls and in pa... AIM： To evaluate the effect of an intravenous bolus of mannitol in altering brain metabolites, brain water content, brain parenchyma volume, cerebrospinal fluid （CSF） volume and clinical signs in controls and in patients with acute liver failure （ALF） and acute- on-chronic liver failure （ACLF）, by comparing changes in conventional magnetic resonance imaging （MRI）, in vivo proton magnetic resonance spectroscopy （PMRS） and diffusion tensor imaging （DTI） before and after its infusion.METHODS： Five patients each with ALF and ACLF in grade 3 or 4 hepatic encephalopathy and with clinical signs of raised intracranial pressure were studied along with five healthy volunteers. After baseline MRI, an intravenous bolus of 20% mannitol solution was given over 10 min in controls as well as in patients with ALF and ACLE Repeat MRI for the same position was acquired 30 rnin after completing the rnannitol injection. RESULTS： No statistically significant difference was observed between controls and patients with ALF and ACLF in metabolite ratios, DTI metrics and brain volume or CSF volume following 45 rain of mannitol infusion. There was no change in clinical status at the end of post-mannitol imaging. CONCLUSION： The osmotic effect of mannitol did not result in significant reduction of brain water content, alteration in metabolite ratios or any change in the clinical status of these patients during or within 45 min of mannitol infusion. 展开更多
关键词 Mannitol Acute liver failure Acute-on-chronic liver failure Proton MR spectroscopy Diffusion tensor imaging
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Diffusion tensor imaging with multiple diffusion-weighted gradient directions 认领 引用 被引量：3
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作者 Shan Jiang Meixia Liu +1 位作者 Tong Han Weihua Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第1期66-71,共6页
Diffusion tensor MRI （DT-MRI or DTI） is emerging as an important non-invasive technology for elucidating intemal brain structures. It has recently been utilized to diagnose a series of diseases that affect the integ... Diffusion tensor MRI （DT-MRI or DTI） is emerging as an important non-invasive technology for elucidating intemal brain structures. It has recently been utilized to diagnose a series of diseases that affect the integrity of neural systems to provide a basis for neuroregenerative studies. Results from the present study suggested that neural tissue is reconstructed with multiple diffusion-weighted gradient directions DTI, which varies from traditional imaging methods that utilize 6 gradient directions. Simultaneously, the diffusion tensor matrix is obtained by multiple linear regressions from an equation of echo signal intensity. The condition number value and standard deviation of fractional anisotropy for each scheme can be used to evaluate image quality. Results demonstrated that increasing gradient direction to some extent resulted in improved effects. Therefore, the traditional 6 and 15 directions should not be considered optimal scan protocols for clinical DTI application. In a scheme with 20 directions, the condition number and standard deviation of fractional anisotropy of the encoding gradients matrix were significantly reduced, and resulted in more clearly and accurately displayed neural tissue. Results demonstrated that the scheme with 20 diffusion gradient directions provided better accuracy of structural renderings and could be an optimal scan protocol for clinical DTI application. 展开更多
关键词 diffusion tensor imaging neural tissue tensor matrix multiple linear regression condition number
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Changes in a cerebellar peduncle lesion in a patient with Dandy-Walker malformation A diffusion tensor imaging study 认领 引用 被引量：2
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作者 Ah Young Lee Sung Ho Jang +3 位作者 Sang Seok Yeo Ensil Lee Yun Woo Cho Su Min Son 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第5期474-478,共5页
We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was d... We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolled. The superior cerebellar peduncle, the middle cerebellar peduncle, and the inferior cerebellar peduncle were evaluated using fractional anisotropy and the apparent diffusion coefficient. The patients＇ functional ambulation category was 0 at the initial visit, but improved to 2 at the follow-up evaluation, and Berg＇s balance scale score also improved from 0 to 7. Initial diffusion tensor tractography revealed that the inferior cerebellar peduncle was not detected, that the fractional anisotropy of the superior cerebellar peduncle and middle cerebellar peduncle decreased by two standard deviations below, and that the apparent diffusion coefficient increased by two standard deviations over normal control values. However, on follow-up diffusion tensor tractography, both inferior cerebellar peduncles could be detected, and the fractional anisotropy of superior cerebellar peduncle increased to within two standard deviations of normal controls. The functional improvement in this patient appeared to correspond to changes in these cerebellar peduncles. We believe that evaluating cerebellar peduncles using diffusion tensor imaging is useful in cases when a cerebellar peduncle lesion is suspected. 展开更多
关键词 neural regeneration neuroimaging Dandy-Walker malformation cerebellar peduncle ataxia cerebral palsy functional ambulation category Berg＇s balance scale fractional anisotropy apparent diffusion coefficient diffusion tensor tractography diffusion tensor imaging grants-supported paper photographs-containing paper neuroregeneration
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Correlation of diffusion tensor imaging and cognitive function in patients with leukoaraiosis 认领 引用 被引量：2
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作者 Chuanqiang Qu Shougang Guo +4 位作者 Hongzhi Guo Xiangshui Meng Chunjuan Wang Lin Ma Yan He 《Neural Regeneration Research》 SCIE CAS 2010年第15期1190-1195,共6页
Conventional imaging technology does not measure white matter lesions of the brain or cognitive impairment. Diffusion tensor imaging is able to detect changes in the microstructure of white matter, and correlating vas... Conventional imaging technology does not measure white matter lesions of the brain or cognitive impairment. Diffusion tensor imaging is able to detect changes in the microstructure of white matter, and correlating vascular risk factors with cognitive dysfunction seems feasible using this technique. A total of 60 leukoaraiosis patients and 30 healthy elderly controls received diffusion tensor imaging examination to detect the average diffusion coefficient and fractional anisotropy of leukoaraiosis lesion and normal white matter. Leukoaraiosis severity positively correlated with average diffusion coefficient but negatively correlated with fraction anisotropy. Neuropsychology tests （mini-mental state examination） were related to average diffusion coefficient and fraction anisotropy of normal white matter in leukoaraiosis patients, especially in the anterior horn and centrum semiovale. The average diffusion coefficient and fraction anisotropy of leukoaraiosis displayed characteristic changes. Therefore, diffusion tensor imaging can detect the macrostructural changes in white matter with normal magnetic resonance imaging, and these changes are related to cognitive function. Application of diffusion tensor imaging techniques to analyze the correlation between vascular risk factors and cognitive dysfunction is feasible. 展开更多
关键词 diffusion tensor imaging cognitive function leukoaraiosis elderly magnetic resonance imaging neural regeneration
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Age-related changes of the corticospinal tract in the human brain A diffusion tensor imaging study 认领 引用 被引量：2
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作者 Sung Ho Jang Sang-Hyun Cho +2 位作者 Mi Young Lee Yong Hyun Kwon Min Cheul Chang 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第4期283-287,共5页
The corticospinal tract （CST） is one of the most important neural tracts for motor function in the human brain. Little is known about age-related changes of the CST. tn this study, we tried to evaluate age-related c... The corticospinal tract （CST） is one of the most important neural tracts for motor function in the human brain. Little is known about age-related changes of the CST. tn this study, we tried to evaluate age-related changes of the CST using diffusion tensor imaging in 60 healthy subjects. The diffusion tensor imaging result revealed that the tract number and fractional anisotropy value were decreased, and the apparent diffusion coefficient （ADC） value was increased with aging. The distribution showed a semilog pattern for tract number, fractional anisotropy and ADC of the CST, and the pattern of each graph was near-linear. When compared with the diffusion tensor imaging parameters of subjects in the 20 s age group, tract number and fractional anisotropy values were significantly decreased in the 50 s-70 s age groups. Likewise, the ADC value was significantly higher in the 50 s-70 s age groups. The CST in the brain of normal subjects degenerated continuously from the 20 s to the 70 s, with a near-linear pattern, and degeneration of the CST began to manifest significantly in the subjects in their 50 s, compared with the subjects in their 20 s. 展开更多
关键词 corticospinal tract motor function aging diffusion tensor imaging
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Changes in brain function and anatomical structure following treatment of hyperbaric oxygen for visual pathway abnormalities in 16 cases Evaluation of functional magnetic resonance imaging combined with diffusion tensor imaging 认领 引用 被引量：2
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作者 Ziqian Chen Ping Ni +6 位作者 Hui Xiao Jinhua Chen Gennian Qian Youqiang Ye Shangwen Xu Jinliang Wang Xizhang Yang 《Neural Regeneration Research》 SCIE CAS 2008年第2期117-123,共7页
BACKGROUND： There is a growing research focus on the combination of blood oxygenation level dependent functional magnetic resonance imaging （BOLD-fMRI） and diffusion tensor imaging （DTI） to evaluate visual cortic... BACKGROUND： There is a growing research focus on the combination of blood oxygenation level dependent functional magnetic resonance imaging （BOLD-fMRI） and diffusion tensor imaging （DTI） to evaluate visual cortical function and structural changes in the cerebrum, as well as morphological changes to the white matter fiber tracks, after visual pathway lesions. However, the combined application of BOLD-fMRI and DTI in treating of visual pathway abnormalities still requires further studies. OBJECTIVE： To observe and evaluate the effects of hyperbaric oxygen on visual pathway abnormalities, and to evaluate the characteristics of cerebral function and anatomic structural changes by using BOLD-fMRI combined with DTI technique. DESIGN： Case contrast observation. SETTING： Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA. PARTICIPANTS： Sixteen patients （9 males and 7 females, 15-77 years old） with lateral or bilateral visual disorder induced by visual pathway lesions were selected from the Department of Neurology, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA from January 2006 to May 2007. These patients comprised the lesion group. Measures of interventional therapy： hyperbaric oxygen of two normal atmospheres for three courses （10 d/course） and routine internal medicine treatment. In addition, 12 healthy subjects of similar sex and age to the lesion group were regarded as the control group. The control group underwent routine ophthalmological and ocular fundus examinations; diagnostic results were normal. The experiment received confirmed consent from the local ethic committee, and all patients provided informed consent. METHODS： BOLD-fMRI and DTI manifestations in the lesion group were observed before and after hyperbaric oxygen intervention, and the results were compared with the control group. The subjects were positioned on their back, and BOLD-fMRI images were collected with the following GRE EPI sequence： TR = 2 000 ms, TE = 40 ms, layer thickness = 5 mm, and 20-layer successive scanning to cover the whole brain. While, DTI images were collected with SE EPI sequence of single excitation： TR=10 000 ms, TE = 112 ms, layer thickness = 4 mm, layer spacing = 0.5 mm, and a 30-layer successive scanning, matrix = 128×128. A diffusion gradient was applied at 13 directions, and one layer without diffusion weighted imaging was collected at b =1 000 s/mm^2. Numbers of activated voxels in cortical-activated regions, and fractional anisotropy in bilateral cerebral optical radiation regions, were calculated. Displacement, continuity, and destruction of fibrous tracts were analyzed. MAIN OUTCOME MEASURES： Results of BOLD-fMRI and DTI examinations. RESULTS： All 16 patients and 12 controls were included in the final analysis. ① Numbers of activated voxels through the use of BOLD-fMRI： prior to hyperbaric oxygen therapy, the number of activated voxels in the bilateral cortex of occipital lobe were significantly less in the lesion group than in the control group （t =3.23, P 〈 0.01）. In addition, the number of activated voxels significantly increased after treatment compared to before treatment （t = 2.46, P 〈 0.05）. ② Fractional anisotropy in optical radiation regions of bilateral cerebrum： fractional anisotropy in the lesion group was significantly less than the control group （t =2.89, P 〈 0.05）. In addition, fractional anisotropy after treatment was significantly higher than before treatment （t = 2.48, P 〈 0.05）. Moreover, fractional anisotropy of optical neuropathy was significantly higher in 6 patients in the lesion group than the occipital lobe optical central lesion （t = 2.35, P 〈 0.05）. CONCLUSION： BOLD-fMRI combined with DTI can indicate the occurrence, development, and therapeutic course of action for optical pathway lesions. The results acquired from these methods can provide information for function and structure, which can provide reliable verification in the treatment of cerebral function. 展开更多
关键词 vision functional magnetic resonance imaging diffusion tensor imaging hyperbaric oxygen therapy
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Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury 认领 引用 被引量：1
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作者 Chang-Bin Liu De-Gang Yang +5 位作者 Jun Li Chuan Qin Xin Zhang Jun Liu Da-Peng Li Jian-Jun Li 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第1期176-182,共7页
Based on the Wallerian degeneration in the spinal cord pathways,the changes in synaptic connections,and the spinal cord-related cellular responses that alter the cellular structure of the brain,we presumed that brain ... Based on the Wallerian degeneration in the spinal cord pathways,the changes in synaptic connections,and the spinal cord-related cellular responses that alter the cellular structure of the brain,we presumed that brain diffusion tensor imaging(DTI)parameters may change after spinal cord injury.However,the dynamic changes in DTI parameters remain unclear.We established a Beagle dog model of T10 spinal cord contusion and performed DTI of the injured spinal cord.We found dynamic changes in DTI parameters in the cerebral peduncle,posterior limb of the internal capsule,pre-and postcentral gyri of the brain within 12 weeks after spinal cord injury.We then performed immunohistochemistry to detect the expression of neurofilament heavy polypeptide(axonal marker),glial fibrillary acidic protein(glial cell marker),and NeuN(neuronal marker).We found that these pathological changes were consistent with DTI parameter changes.These findings suggest that DTI can display brain structure changes after spinal cord injury. 展开更多
关键词 spinal cord injury diffusion tensor imaging canines pathophysiology cerebrospinal structures corticospinal tract magnetic resonance imaging anisotropic fraction apparent dispersion coefficient
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Diffusion tensor imaging study of fractional anisotropy values and the area of both cerebral peduncles in healthy adults 认领 引用 被引量：1
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作者 Zhibin Song Suyue Pan +3 位作者 Yanling Zhou Yanjiang Dong Haimao Liang Zhengfeng Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第10期797-800,共4页
Diffusion tensor imaging was performed in 105 volunteers free of central nervous system lesions.No differences were found in fractional anisotropy between the left and right cerebral peduncles among subjects（P 0.05）... Diffusion tensor imaging was performed in 105 volunteers free of central nervous system lesions.No differences were found in fractional anisotropy between the left and right cerebral peduncles among subjects（P 0.05）.The lower limit value of fractional anisotropy was 0.36,and the asymmetry ratio was 0.77.The area and lower limit value of the cerebral peduncles were 0.90 cm2 and 0.83,respectively.These results will be useful in evaluating the diagnosis of Wallerian degeneration following cerebral infarction. 展开更多
关键词 healthy Chinese people cerebral peduncle fractional anisotropy area diffusion tensor imaging
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Imaging changes in neural circuits in patients with depression using 1 H-magnetic resonance spectroscopy and diffusion tensor imaging 认领 引用 被引量：2
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作者 Shaoqiong Chen Lisha Lai +3 位作者 Zhuang Kang Xiao Luo Jiansheng Zhang Jianfang Li 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第24期1881-1888,共8页
1 H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 controls.The mean age of the patients was 31 years.The mean Hamilton depression sco... 1 H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in 19 patients with mild depression and in 13 controls.The mean age of the patients was 31 years.The mean Hamilton depression score of the patients was 22.5±13.2.N-acetylaspartate,choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus,striatum,thalamus and prefrontal deep white matter. Compared with the control group,the mild depressed patients had：（1）a higher choline/creatine ratio and a negative correlation between the choline/creatine ratio and the average diffusion coefficient in the hippocampus;（2）a lower choline/creatine ratio and a higher fractional anisotropy in the striatum;（3）a lower fractional anisotropy and a positive correlation between the fractional anisotropy and the choline/creatine ratio in the prefrontal deep white matter;and（4）a higher average diffusion coefficient and a positive correlation between the choline/creatine ratio and the N-acetylaspartate/creatine ratio in the thalamus,as well as positive correlation between the choline/creatine ratio and Hamilton depression scores.These data suggest evidence of abnormal connectivity in neurofibrotic microstructures and abnormal metabolic alterations in the limbic-cortical-striatal-pallidal-thalamic neural circuit in patients with mild depression. 展开更多
关键词 depression diffusion tensor imaging hippocampus magnetic resonance spectroscopy nerve fiber neural circuit neurotransmitter neural regeneration
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