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Naloxone plus enteral nutrition for gastrointestinal dysfunction in elderly cerebral infarction and peptic ulcer patients 认领 引用
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作者 Xin-Xin Chen Xue-Fei Han Yan Chu 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期288-295,共8页
BACKGROUND Cerebral infarction(CI)is a major subtype of ischemic stroke,with high incidence,recurrence rate,disability rate,and mortality rate in the elderly.Elderly CI patients are prone to peptic ulcer due to long-t... BACKGROUND Cerebral infarction(CI)is a major subtype of ischemic stroke,with high incidence,recurrence rate,disability rate,and mortality rate in the elderly.Elderly CI patients are prone to peptic ulcer due to long-term use of antiplatelet drugs and stress factors,which further leads to gastrointestinal dysfunction,seriously affecting nutritional intake and rehabilitation.Naloxone,an opioid receptor antagonist,has neuroprotective potential,and enteral nutrition(EN)can improve gastrointestinal function.This study aims to explore the intervention effect of their combination.AIM To investigate the efficacy of naloxone combined with EN on gastrointestinal dysfunction in elderly patients with CI and peptic ulcer.METHODS In this randomized controlled trial,110 elderly patients with CI and peptic ulcer were equally assigned to a control group(receiving standard therapy combined with EN)or a combination group(receiving standard therapy,EN,and naloxone).The National Institute of Health Stroke Scale(NIHSS)scores,Barthel Index(BI),Chinese version of the MOS 36-Item Short Form Health Survey(SF-36)scores,gastrointestinal function scores,and serum levels of motilin(MTL),gastrin(GAS),and somatostatin(SS)were compared.Adverse reactions were also recorded.RESULTS Compared with the control group,the combination group had lower NIHSS scores(5.88±1.07 vs 8.73±1.14,P<0.001)and gastrointestinal dysfunction scores(5.14±1.27 vs 8.62±1.31,P<0.001),higher BI(87.36±4.42 vs 72.29±3.23,P<0.001)and SF-36 scores(76.26±3.85 vs 70.21±3.66,P<0.001),increased serum MTL(201.31±12.35 ng/L vs 186.81±11.18 ng/L,P<0.001)and GAS levels(94.46±9.64 pg/mL vs 103.15±10.52 pg/mL,P<0.001),and decreased SS levels(5.69±1.25 pg/mL vs 8.31±1.19 pg/mL,P<0.001).No significant difference in the incidence of adverse reactions was found between the two groups.CONCLUSION The combination of naloxone and EN is a safe and efficacious therapeutic approach for ameliorating gastrointestinal dysfunction and promoting overall recovery in elderly individuals with CI and peptic ulcer. 展开更多
关键词 Naloxone Enteral nutrition support Cerebral infarction Peptic ulcer Gastrointestinal dysfunction
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Construction of a risk prediction model for postoperative gastrointestinal dysfunction and prevention in patients with gastrointestinal tumors 认领 引用
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作者 Xiao-Hui Wang Yi Wang +3 位作者 Xi Liu Xiao-Lan Ouyang Fen Xie Lu Liao 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第2期231-239,共9页
BACKGROUND The global incidence of gastrointestinal tumors is continuously increasing.Surgery remains the primary treatment modality.However,postoperative gastrointestinal dysfunction remains prevalent,severely impedi... BACKGROUND The global incidence of gastrointestinal tumors is continuously increasing.Surgery remains the primary treatment modality.However,postoperative gastrointestinal dysfunction remains prevalent,severely impeding patient recovery and increasing medical burden.Existing research investigating risk prediction and preventive management has some limitations.AIM To construct a risk-prediction model for postoperative gastrointestinal dysfunction in patients with gastrointestinal tumors and explore preventive management strategies.METHODS Data from 176 patients who underwent gastrointestinal tumor surgery at the authors’hospital between November 2022 and November 2024 were included.Patients were divided into groups according to Tilburg Frailty Scale scores on postoperative day 5.Risk factors were screened using univariate and multivariate logistic regression analyses to establish a model,and the effectiveness of preventive management measures was evaluated.RESULTS Seven factors including age,sex,body mass index,tumor stage,operative duration,and preoperative hemoglobin and albumin levels were identified as independent risk factors.The constructed model had an area under the receiver operating characteristic curve of 0.895.The incidence of postoperative gastrointestinal dysfunction in the intervention group was significantly lower than that in the control group using preventive management measures based on the model.CONCLUSION An effective risk-prediction model was constructed and independent risk factors were identified.Preventive management measures based on this model can reduce risk and provide a scientific basis for clinical practice. 展开更多
关键词 Gastrointestinal neoplasms Postoperative gastrointestinal dysfunction Risk prediction model Preventive management Intestinal barrier function
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Multifactorial Pathogenesis and Clinical Characteristics Analysis of Gastrointestinal Dysfunction After Gastrointestinal Surgery 认领 引用
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作者 ZHOU Biao 《外文科技期刊数据库（文摘版）医药卫生》 2026年第5期015-019,共5页
Postoperative gastrointestinal dysfunction (POGD) is one of the most common complications after gastrointestinal surgery, with clinical manifestations ranging from mild intolerance to enteral nutrition to severe intes... Postoperative gastrointestinal dysfunction (POGD) is one of the most common complications after gastrointestinal surgery, with clinical manifestations ranging from mild intolerance to enteral nutrition to severe intestinal ischemia and multiple organ dysfunction syndrome. This study aims to explore the multifactorial pathogenesis of POGD and analyze its clinical characteristics, so as to provide a theoretical basis for early clinical identification and intervention. A retrospective analysis was performed on 438 patients who underwent gastrointestinal surgery in our hospital from January 2021 to December 2023. The incidence of POGD was counted, and the correlation between clinical factors and POGD was analyzed through univariate and multivariate regression. The results showed that the total incidence of POGD in this group was 27.17%, which was the most common type of postoperative complications. Multivariate regression analysis showed that surgical trauma (OR=3.21, 95%CI: 1.87-5.52), postoperative electrolyte disturbance (OR=2.76, 95%CI: 1.53-4.98), opioid analgesic use (OR=2.49, 95%CI: 1.42-4.36), and postoperative abdominal infection (OR=2.18, 95%CI: 1.25-3.81) were independent risk factors for POGD. Clinically, POGD is most likely to occur on the 5th, 8th and 15th days after surgery, and the main clinical manifestations include abdominal distension, nausea, vomiting, constipation and intolerance to enteral diet. In conclusion, POGD is a common complication after gastrointestinal surgery caused by the interaction of multiple factors. Understanding its multifactorial pathogenesis and clinical characteristics is helpful for clinical risk stratification and early intervention, which can effectively reduce the prolongation of hospital stay and the increase of medical costs caused by POGD. 展开更多
关键词 Postoperative gastrointestinal dysfunction Gastrointestinal surgery Pathogenesis Clinical characteristics Risk factor
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Gastrointestinal dysfunction after brain injury:Mechanisms and the role of the brain-gut axis 认领 引用
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作者 Xia Zhao Wei Zhang +1 位作者 Ying Zhang Xing-An Liu 《World Journal of Gastroenterology》 SCIE CAS 2026年第10期8-22,共15页
Brain injury(BI)encompasses traumatic BI and stroke,and is a leading cause of mortality and morbidity worldwide.In addition to primary brain damage,BI can cause a series of sequelae,of which gastrointestinal(GI)dysfun... Brain injury(BI)encompasses traumatic BI and stroke,and is a leading cause of mortality and morbidity worldwide.In addition to primary brain damage,BI can cause a series of sequelae,of which gastrointestinal(GI)dysfunction is one of the most important affecting patient outcomes.GI dysfunction,including delayed gastric emptying,increased intestinal permeability,and gut dysbiosis,is common among patients with BI.GI dysfunction not only impairs nutrient absorption and increases the risk for infection,but also enhances secondary BI by aggravating the systemic inflammatory response.The brain-gut axis refers to the bidirectional communication network between the central nervous system and enteric nervous system.This article provides an overview of the mechanisms underlying GI dysfunction after BI and the close relationship with the brain-gut axis.Furthermore,the potential mechanisms underlying brain-gut modulation by probiotics,fecal microbiota transplantation,and vagus nerve stimulation are discussed,which may provide new insights into the treatment of GI dysfunction in patients with BI.An in-depth understanding of the interaction between the brain and GI system is essential to develop more effective therapeutic strategies to alleviate patient suffering and improve survival and quality of life. 展开更多
关键词 Brain injury Gastrointestinal dysfunction Brain-gut axis Neuroinflammation Gut microbiota
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Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction 认领 引用
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作者 Yi-Xiao Chen Na-Qi Sun Sai-Jun Mo 《World Journal of Gastroenterology》 SCIE CAS 2026年第4期121-125,共5页
This commentary provides a critical evaluation of the study by Wang et al,which focuses on rhapontin activating colonic nuclear factor erythroid 2-related factor 2(NRF2)to explore its therapeutic potential for Parkin... This commentary provides a critical evaluation of the study by Wang et al,which focuses on rhapontin activating colonic nuclear factor erythroid 2-related factor 2(NRF2)to explore its therapeutic potential for Parkinson’s disease(PD)-associated gastrointestinal dysfunction.The commentary acknowledges the academic value of the study:It has not only validated intestinal NRF2 as a therapeutic target for PD but also provided experimental support for the“enteric pathology hypothesis”.However,several key gaps remain unresolved in the study.At the gut microbiota level,the exploration of the causal relationship of the microbiota is insufficient,with no validation conducted via methods such as fecal microbiota transplantation;additionally,it fails to systematically integrate the gut-brain axis with PD and does not assess the impact of rhapontin on the composition or function of the gut microbiota.At the pathway mechanism level,it lacks an analysis of the crosstalk between NRF2 and other rhapontin-targeted pathways,including nuclear factor kappa-B,mitogen-activated protein kinase,adenosine monophosphate-activated protein kinase,and sirtuin 1.At the experimental method level,the behavioral testing methods for PD mouse models and the limitations of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models need attention.Additionally,certain flaws exist in some experimental result figures.Furthermore,this commentary puts forward improvement suggestions for the study.Future research should prioritize multi-omics analysis,encompassing combined metabolomics and metagenomics detection,while conducting mechanistic validation of NRF2-interacting molecules(KEAP1 and p62).In addition,it is necessary to improve refined behavioral tests,focusing on incorporating cognitive function and anxiety-related assessment items. 展开更多
关键词 Rhapontin Gastrointestinal dysfunction Parkinson’s disease Nuclear factor erythroid 2-related factor 2 Antiinflammatory
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Early-life gastrointestinal inflammation and the developing brain:Unravelling the pathways to long-term cognitive dysfunction 认领 引用
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作者 Mohammed Al-Beltagi Nermin Kamal Saeed +2 位作者 Yasser El-Sawaf Adel Salah Bediwy Reem Elbeltagi 《World Journal of Clinical Pediatrics》 2026年第2期1-31,共31页
The gut-brain axis(GBA)is a complex,bidirectional communication network critical to integrating central nervous system functions with gastrointestinal(GI)health.This review examines how disruptions to the GBA during t... The gut-brain axis(GBA)is a complex,bidirectional communication network critical to integrating central nervous system functions with gastrointestinal(GI)health.This review examines how disruptions to the GBA during the critical early-life developmental window–a period of rapid neurogenesis and microbial colonization–contribute to long-term neurocognitive and psychiatric vulnerabilities.Evidence from animal models demonstrates that early-life stress,antibiotics,and infection induce sustained neuro-inflammation and alter microglial function,leading to long-term behavioral and cognitive impairments in adulthood.Human studies corroborate these findings,revealing that severe early GI insults,such as necrotizing enterocolitis,confer a high risk(40%)of global neurodevelopmental impairment and specific attention deficits.Chronic inflammatory conditions similarly impact the central nervous system:A high burden of early severe enteric infection is an independent risk factor for diminished intelligence quotient(IQ)and executive function,while conditions like celiac disease and inflammatory bowel disease are associated with persistent deficits in attention,processing speed,memory,and executive function.These clinical outcomes are strongly linked to systemic inflammation[elevated interleukin-6,kynurenine-to-tryptophan(Kyn:Trp)ratio],micronutrient deficiencies(iron,vitamin B12,folate),and structural white matter changes in the brain.Furthermore,chronic GI disease imposes a significant psychiatric burden,with high comorbidity of anxiety and depression often mediating poor health-related quality of life,particularly in pediatric inflammatory bowel disease.The findings underscore the necessity for a shift in clinical practice:Chronic GI disease in early life must be recognized as a red flag for neurocognitive risk.We advocate for a multidisciplinary approach encompassing early neurodevelopmental follow-up for high-risk groups and routine screening for cognitive and emotional comorbidities.Future research must focus on long-term prospective cohorts,identifying precise mechanistic biomarkers(metabolomics,microbiome signatures),and conducting interventional trials targeting the GBA to mitigate these long-term functional consequences. 展开更多
关键词 Gut-brain axis Neurodevelopment Necrotizing enterocolitis Inflammatory bowel disease Celiac disease Cognitive dysfunction Microbiome
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Serum inflammatory biomarkers can predict clinical outcomes in patients with sepsis-associated gastrointestinal dysfunction 认领 引用
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作者 You-Hui Liu Qing-Yang Chen +1 位作者 Fei-Yue Dai Xin-Yu Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第2期139-146,共8页
BACKGROUND Effective predictive indicators for clinical outcomes in septic patients with gastrointestinal dysfunction(GID)remain lacking.AIM To evaluate the relationship between serum inflammatory biomarkers(SIBs)and ... BACKGROUND Effective predictive indicators for clinical outcomes in septic patients with gastrointestinal dysfunction(GID)remain lacking.AIM To evaluate the relationship between serum inflammatory biomarkers(SIBs)and clinical outcomes in patients with sepsis-induced GID.METHODS A total of 117 sepsis-induced GID patients were selected(January 2021 to January 2025).They were grouped into poor[n=76;Acute Physiology and Chronic Health Evaluation II(APACHE II)score>10]and good(n=41;APACHE II≤10)prognosis groups based on outcomes.Clinical variables(sex,age,body mass index,smoking history,diabetes,hypertension,and infection site)were collected.SIBs,encompassing procalcitonin(PCT),C-reactive protein(CRP),interleukin(IL)-6/10,and tumor necrosis factor(TNF)-α,were analyzed.Correlation analyses were conducted to assess the associations of SIBs with Sequential Organ Failure Assessment(SOFA)and APACHE II scores.Receiver operating characteristic curves visualized SIBs’predictive performance,and multivariate analysis identified independent outcome predictors.RESULTS The groups were similar in age,sex,body mass index,comorbidities,and major infection site.The poor prognosis group exhibited elevated APACHE II,SOFA,PCT,CRP,IL-6,IL-10,and TNF-αthan the good prognosis cohort.SIBs correlated positively with both APACHE II and SOFA scores.When used to predict outcomes individually,SIBs yielded an area under the curve range of 0.660-0.780 in septic patients with GID,whereas combined biomarker analysis increased the area under the curve to 0.906.APACHE II,SOFA,PCT,CRP,IL-6,and TNF-αacted as independent predictors of prognosis.CONCLUSION SIBs correlate intimately with clinical outcomes in sepsis-induced GID patients. 展开更多
关键词 Serum inflammatory biomarkers Procalcitonin C-reactive protein Interleukin-6/10 Sepsis Gastrointestinal dysfunction Clinical outcome Predictive value
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Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala 认领 引用 被引量：1
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作者 Hong-Kun Ma Shan-Lan Zhu +5 位作者 Xue-Yan Li Yi Yuan Qing-Yang Huang Hao Wang Guo-Ming Shen Xi-Yang Wang 《World Journal of Psychiatry》 SCIE 2026年第2期357-376,共20页
BACKGROUND Depression is frequently accompanied by gastrointestinal disturbances,reflecting the close interplay between emotional regulation and gut physiology.The central amygdala(CeA),particularly its GABAergic neur... BACKGROUND Depression is frequently accompanied by gastrointestinal disturbances,reflecting the close interplay between emotional regulation and gut physiology.The central amygdala(CeA),particularly its GABAergic neurons,has been identified as a critical hub within the brain-gut axis.However,the mechanisms by which CeA inhibitory neurons mediate comorbid depressive and gastrointestinal symptoms remain poorly understood,and their potential as therapeutic targets has not been fully explored.AIM To investigate CeA GABAergic mechanisms linking mood and gastric function and to appraise the efficacy of electroacupuncture(EA).METHODS A mouse model of chronic unpredictable mild stress(CUMS)was used to induce depressive-like behavior and gastric dysfunction.Behavioral tests,gastric motility assays,and fluorescent gastric emptying imaging were performed.CeA GABAergic activity was examined using immunofluorescence,calcium imaging,and chemogenetic modulation.EA was applied at CV12 and ST36 acupoints,and its therapeutic effects were evaluated across behavioral and gastric measures.RESULTS CUMS mice exhibited reduced exploration,anhedonia,increased immobility,impaired gastric motility,and delayed gastric emptying.Immunofluorescence and calcium imaging revealed hyperactivation of CeA GABAergic neurons.Chemogenetic activation reproduced depressive-like behavior and gastric dysfunction,whereas inhibition alleviated them.EA improved behavioral outcomes,restored gastric motility,and partially reversed the pathological effects of CeA overactivation.These findings demonstrate that CeA GABAergic neurons are central to the comorbidity of depression and gastrointestinal dysfunction,and that EA exerts its therapeutic effects by modulating their activity.CONCLUSION EA attenuates depressive-like and gastric deficits in CUMS mice,with evidence implicating CeA GABAergic neurons as a contributory node. 展开更多
关键词 Chronic stress Depression Central amygdala GABAergic neurons Electroacupuncture Gastrointestinal motility Gut-brain axis
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Nomogram integrating systemic immune-inflammation index and blood lipid ratio to predict postoperative gastrointestinal dysfunction in elderly gallstone patients 认领 引用
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作者 Yuan-Yuan Zhu Jing-Ran Li Ling Jia 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第5期228-239,共12页
BACKGROUND Gastrointestinal dysfunction is a common complication in elderly patients with cholelithiasis after undergoing laparoscopic cholecystectomy,and it can markedly hinder postoperative recovery.The systemic imm... BACKGROUND Gastrointestinal dysfunction is a common complication in elderly patients with cholelithiasis after undergoing laparoscopic cholecystectomy,and it can markedly hinder postoperative recovery.The systemic immune-inflammation index(SII)and the total cholesterol(TC)/high-density lipoprotein cholesterol ratio(HDL-C)may reflect the underlying inflammatory and metabolic states associated with postoperative outcomes.However,the combined predictive value of these two indicators remains unclear.AIM To develop a nomogram based on SII and TC/HDL-C for predicting poor postoperative gastrointestinal function in elderly patients with gallstones.METHODS In this retrospective cohort study,123 elderly patients with cholelithiasis from Hefei BOE Hospital were included and randomly assigned to the modeling cohort(n=86)and the validation cohort(n=37)in a 7:3 ratio.Gastrointestinal function was evaluated 30 days after surgery.Risk factors were identified using binary logistic regression.A nomogram was then constructed,and its performance was evaluated using the area under the curve,calibration curve,and decision curve analysis.RESULTS In the modeling cohort,TC/HDL-C,SII,operation time,TC,neutrophil count,lymphocyte count,gallbladder wall thickness>5 mm,and postoperative ambulation time≥1 day were significantly higher in the poor gastrointestinal function group than in the good function group(P<0.05).Logistic regression analysis identified TC/HDL-C[odds ratio(OR)=1.628,95%confidence interval(CI):1.378-1.869],SII(OR=3.411,95%CI:1.763-5.509),gallbladder wall thickness(OR=1.524,95%CI:1.167-1.881),operation time(OR=2.406,95%CI:1.858-2.954),and postoperative ambulation time(OR=3.457,95%CI:1.109-5.805)as independent risk factors for postoperative gastrointestinal dysfunction.The area under the curves of the nomogram in the modeling and validation cohorts were 0.889 and 0.828,respectively.The calibration and decision curves indicated that the model demonstrated good consistency and clinical utility.CONCLUSION The nomogram model developed based on the SII and TC/HDL-C provides a reliable tool for preoperative risk stratification and may assist in guiding individualized perioperative management. 展开更多
关键词 Systemic immune-inflammation index Total cholesterol to high-density lipoprotein cholesterol ratio Gallstones Gastrointestinal function Nomogram
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The Efficacy of Traditional Chinese Medicine Hotpack Therapy for Postoperative Gastrointestinal Dysfunction in Patients with Gastrointestinal Malignancies 认领 引用
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作者 Liya Tian Aiyun Huang +2 位作者 Jingyan Yang Caizhi Xiao Jun Zhang 《Expert Review of Chinese Medical》 2025年第2期1-3,共3页
Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)hot-pack therapy in treating postoperative gastrointestinal dysfunction in patients undergoing surgery for gastrointestinal malignancies.... Objective To evaluate the clinical efficacy of Traditional Chinese Medicine(TCM)hot-pack therapy in treating postoperative gastrointestinal dysfunction in patients undergoing surgery for gastrointestinal malignancies.Method 60 postoperative patients with gastrointestinal malignancies were randomized into a treatment group(n=30)and a control group(n=30).Both groups received standard postoperative supportive care,including oral mosapride citrate(5 mg,three times daily,starting 6 h post-op,for 3 days).The treatment group additionally received external abdominal application of a TCM hot-pack twice daily(20-30 min each)for 3 days.Primary endpoints were time to first flatus,first defecation,and first oral intake.Secondary endpoints included numeric scores for abdominal pain and distension at 24 h and 72 h post-op,and overall clinical efficacy.Result Compared with controls,the treatment group showed significantly faster recovery:time to first flatus(50.3±7.8 h vs.62.5±9.4 h),first defecation(72.1±11.3 h vs.85.2±13.6 h),and first oral intake(48.0±9.5 h vs.62.5±12.4 h)(all P<0.01).At 24 h and 72 h,the treatment group reported lower abdominal pain and distension scores(24 h pain 5.1±1.3 vs.6.0±1.4,distension 2.3±0.5 vs.2.8±0.6;72 h pain 3.9±0.8 vs.4.7±0.9,distension 1.9±0.5 vs.2.3±0.6;P<0.05 to P<0.01).Total effective rate was higher in the treatment group(96.7%vs.90.0%,χ2=6.96,P=0.031).Conclusion TCM hot-pack therapy combined with routine care significantly accelerates recovery of gastrointestinal function,shortens duration of postoperative dysfunction,and alleviates abdominal pain and distension in patients after gastrointestinal malignancy surgery,demonstrating notable clinical benefit. 展开更多
关键词 Gastrointestinal malignancies postoperative gastrointestinal dysfunction traditional Chinese medicine hot-pack gastrointestinal function recovery post-operative rehabilitation
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Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice 认领 引用 被引量：1
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作者 Xin-Yu Wang Fang Liu +4 位作者 Qi-Tong Wang Shu-Zhu Li Yu-Zhao Ye Tao Chen Ben-Chi Cai 《World Journal of Gastroenterology》 SCIE CAS 2025年第15期96-108,共13页
BACKGROUND Parkinson's disease(PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction.The exploration of novel therapeutic strategies for PD is vital.AIM To investi... BACKGROUND Parkinson's disease(PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction.The exploration of novel therapeutic strategies for PD is vital.AIM To investigate the potential mechanism of action of rhapontin-a natural compound with known antioxidant and anti-inflammatory properties-in the context of PD.METHODS Network pharmacology was used to predict the targets and mechanisms of action of rhapontin in PD.Behavioral tests and tyrosine hydroxylase immunofluorescence analysis were used to assess the effect of rhapontin on symptoms and pathology in MPTP-induced mice.Interleukin(IL)-6,IL-1β,tumor necrosis factor(TNF)-α,and IL-10 levels in tissues were measured using an enzyme-linked immunosorbent assay(ELISA).Additionally,nuclear factor erythroid 2-related factor 2(NRF2)activation was confirmed using western blotting.RESULTS NRF2 was predicted to be the key transcription factor underlying the therapeutic effects of rhapontin in PD,and its anti-PD action may be associated with its antiinflammatory and antioxidant properties.Rhapontin ameliorated the loss of dopaminergic neurons and gastrointestinal dysfunction in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mice by activating NRF2.Additio-nally,rhapontin treatment significantly decreased pro-inflammatory cytokines(IL-6,TNF-α,IL-1β)in the substantia nigra,striatum,and colon,whereas it increased anti-inflammatory cytokine(IL-10)levels only in the colon,indicating the involvement of gut–brain axis in its neuroprotective potential.Finally,NRF2 was identified as a key transcription factor activated by rhapontin,particularly in the colon.CONCLUSION We elucidated the effects of rhapontin in MPTP-induced PD mouse models using a combination of network pharmacology analysis,behavioral assessments,immunofluorescence,ELISA,and Western blotting.Our findings revealed the multifaceted role of rhapontin in ameliorating PD through its anti-inflammatory and antioxidant properties,particularly by activating NRF2,paving the way for future research into targeted therapies for PD. 展开更多
关键词 Rhapontin Gastrointestinal dysfunction Parkinson’s disease Nuclear factor erythroid 2-related factor 2 Gut-Brain axis Oxidative stress Neuroinflammation
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Comparing gastrointestinal dysfunction score and acute gastrointestinal injury grade for predicting short-term mortality in critically ill patients 认领 引用 被引量：11
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作者 Chao Shen Xi Wang +3 位作者 Yi-Ying Xiao Jia-Ying Zhang Guo-Lian Xia Rong-Lin Jiang 《World Journal of Gastroenterology》 SCIE CAS 2024年第42期4523-4531,共9页
BACKGROUND The prognosis of critically ill patients is closely linked to their gastrointestinal(GI)function.The acute GI injury(AGI)grading system,established in 2012,is extensively utilized to evaluate GI dysfunction... BACKGROUND The prognosis of critically ill patients is closely linked to their gastrointestinal(GI)function.The acute GI injury(AGI)grading system,established in 2012,is extensively utilized to evaluate GI dysfunction and forecast outcomes in clinical settings.In 2021,the GI dysfunction score(GIDS)was developed,building on the AGI grading system,to enhance the accuracy of GI dysfunction severity assessment,improve prognostic predictions,reduce subjectivity,and increase reproducibility.AIM To compare the predictive capabilities of GIDS and the AGI grading system for 28-day mortality in critically ill patients.METHODS A retrospective study was conducted at the general intensive care unit(ICU)of a regional university hospital.All data were collected during the first week of ICU admission.The primary outcome was 28-day mortality.Multivariable logistic regression analyzed whether GIDS and AGI grade were independent risk factors for 28-day mortality.The predictive abilities of GIDS and AGI grade were compared using the receiver operating characteristic curve,with DeLong’s test assessing differences between the curves’areas.RESULTS The incidence of AGI in the first week of ICU admission was 92.13%.There were 85 deaths(47.75%)within 28 days of ICU admission.There was no initial 24-hour difference in GIDS between the non-survival and survival groups.Both GIDS(OR 2.01,95%CI:1.25-3.24;P=0.004)and AGI grade(OR 1.94,95%CI:1.12-3.38;P=0.019)were independent predictors of 28-day mortality.No significant difference was found between the predictive accuracy of GIDS and AGI grade for 28-day mortality during the first week of ICU admission(Z=-0.26,P=0.794).CONCLUSION GIDS within the first 24 hours was an unreliable predictor of 28-day mortality.The predictive accuracy for 28-day mortality from both systems during the first week was comparable. 展开更多
关键词 Critical illness Gastrointestinal dysfunction Acute gastrointestinal injury Prognostic indicators Intensive care unit outcomes Mortality prediction Risk stratification Predictive modeling
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Prognostic factors associated with gastrointestinal dysfunction after gastrointestinal tumor surgery:A meta-analysis 认领 引用 被引量：7
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作者 Jia Song Cong Zhou Tian Zhang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第5期1420-1429,共10页
BACKGROUND Explore the risk factors of gastrointestinal dysfunction after gastrointestinal tumor surgery and to provide evidence for the prevention and intervention of gastrointestinal dysfunction in patients with gas... BACKGROUND Explore the risk factors of gastrointestinal dysfunction after gastrointestinal tumor surgery and to provide evidence for the prevention and intervention of gastrointestinal dysfunction in patients with gastrointestinal tumor surgery.AIM To investigate the potential risk factors for gastrointestinal dysfunction following gastrointestinal tumor surgery and to present information supporting the prevention and management of gastrointestinal dysfunction in surgery patients.METHODS Systematically searched the relevant literature from PubMed,Web of Science,Cochrane Library,Embase,CNKI,China Biomedical Database,Wanfang Database,and Weipu Chinese Journal Database self-established until October 1,2022.Review Manager 5.3 software was used for meta-analysis after two researchers independently screened literature,extracted data,and evaluated the risk of bias in the included studies.RESULTS A total of 23 pieces of literature were included,the quality of which was medium or above,and the total sample size was 43878.The results of meta-analysis showed that the patients were male(OR=1.58,95%CI:1.25-2.01,P=0.002)and≥60 years old(OR=2.60,95%CI:1.76-2.87,P<0.001),physical index≥25.3 kg/m2(OR=1.6,95%CI:1.00-1.12,P=0.040),smoking history(OR=1.89,95%CI:1.31-2.73,P<0.001),chronic obstructive pulmonary disease(OR=1.49,95%CI:1.22-1.83,P<0.001),enterostomy(OR=1.47,95%CI:1.26-1.70,P<0.001),history of abdominal surgery(OR=2.90,95%CI:1.67-5.03,P<0.001),surgical site(OR=1.2,95%CI:1.40-2.62,P<0.001),operation method(OR=1.68,95%CI:1.08-2.62,P=0.020),operation duration(OR=2.65,95%CI:1.92-3.67,P<0.001),abdominal adhesion grade(OR=2.52,95%CI:1.90-3.56,P<0.001),postoperative opioid history(OR=5.35,95%CI:3.29-8.71,P<0.001),tumor TNM staging(OR=2.58,95%CI:1.84-3.62,P<0.001),postoperative blood transfusion(OR=2.92,95%CI:0.88-9.73,P=0.010)is a risk factor for postoperative gastrointestinal dysfunction in patients with gastrointestinal tumors.CONCLUSION There are many factors affecting gastrointestinal dysfunction in gastrointestinal patients after surgery.Clinical staff should identify relevant risk factors early and implement targeted intervention measures on the basis of personalized assessment to improve the clinical prognosis of patients. 展开更多
关键词 Gastrointestinal tumor surgery Postoperative gastrointestinal dysfunction Intestinal paralysis Risk factors Metaanalysis
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Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia:study protocol for a prospective practical randomized controlled trial 认领 引用 被引量：19
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作者 Meng-yue Liu Cheng-wei Wang +1 位作者 Zhou-peng Wu Ning Li 《Journal of Integrative Medicine》 CAS CSCD 2014年第6期512-519,共8页
BACKGROUND:Postoperative gastrointestinal dysfunction(PGD)is one of the most common complications following major surgeries under general anesthesia(GA).Despite ongoing research and new drug treatments,abdominal diste... BACKGROUND:Postoperative gastrointestinal dysfunction(PGD)is one of the most common complications following major surgeries under general anesthesia(GA).Despite ongoing research and new drug treatments,abdominal distension within 24 h postoperatively occurs in 8%–28%of all surgeries.We aim to analyze the effectiveness of preventing PGD by preoperatively stimulating Neiguan(PC6),Zusanli(ST36)and Shangjuxu(ST37)bilaterally twice a day compared with sham-acupuncture treatment and standard treatment.METHODS AND DESIGN:This is a single-center,prospective practical randomized controlled trial.All groups will be given standard treatments.Patients undergoing vascular surgery under GA will be included from the Vascular Surgery Unit in West China Hospital of Sichuan University,China,and divided into three groups.The experimental group will receive routine treatments and acupuncture at PC6,ST36 and ST37 bilaterally with electrical stimulation twice a day for 20 min preoperatively.The sham-acupuncture group will receive pseudo-electroacupuncture at sham acupoints of PC6,ST36 and ST37,which are 1 cun away from the real acupoints.The routine-treatment group will not receive electroacupuncture.The outcomes include the incidence of abdominal distention,abdominal circumference,the degree of abdominal distension,the fi rst time of fl atus and defecation,and hospitalization duration.DISCUSSION:The results from this study will demonstrate whether preoperative electroacupuncture is an effective method for the prevention of PGD in patients undergoing vascular surgery under GA.This study may also provide a standardized acupuncture treatment for reduction of PGD.TRIAL REGISTRATION:This study is registered with the Chinese Clinical Trial Registry:Chi CTR-TRC-13003649. 展开更多
关键词 electroacupuncture gastrointestinal dysfunction vascular surgery study protocol
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COVID-19-induced gastrointestinal autonomic dysfunction:A systematic review 认领 引用 被引量：3
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作者 Reem Elbeltagi Mohammed Al-Beltagi +1 位作者 Nermin Kamal Saeed Adel Salah Bediwy 《World Journal of Clinical Cases》 SCIE 2023年第22期5252-5272,共21页
BACKGROUND It is common for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection to occur in the gastrointestinal tract,which can present itself as an initial symptom.The severity of coronavirus diseas... BACKGROUND It is common for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection to occur in the gastrointestinal tract,which can present itself as an initial symptom.The severity of coronavirus disease 2019(COVID-19)is often reflected in the prevalence of gastrointestinal symptoms.COVID-19 can damage the nerve supply to the digestive system,leading to gastrointestinal autonomic dysfunction.There is still much to learn about how COVID-19 affects the autonomic nervous system and the gastrointestinal tract.AIM To thoroughly explore the epidemiology and clinical aspects of COVID-19-induced gastrointestinal autonomic dysfunction,including its manifestations,potential mechanisms,diagnosis,differential diagnosis,impact on quality of life,prognosis,and management and prevention strategies.METHODS We conducted a thorough systematic search across various databases and performed an extensive literature review.Our review encompassed 113 studies published in English from January 2000 to April 18,2023.RESULTS According to most of the literature,gastrointestinal autonomic dysfunction can seriously affect a patient's quality of life and ultimate prognosis.Numerous factors can influence gastrointestinal autonomic nervous functions.Studies have shown that SARS-CoV-2 has a well-documented affinity for both neural and gastrointestinal tissues,and the virus can produce various gastrointestinal symptoms by reaching neural tissues through different pathways.These symptoms include anorexia,dysgeusia,heartburn,belching,chest pain,regurgitation,vomiting,epigastric burn,diarrhea,abdominal pain,bloating,irregular bowel movements,and constipation.Diarrhea is the most prevalent symptom,followed by anorexia,nausea,vomiting,and abdominal pain.Although COVID-19 vaccination may rarely induce autonomic dysfunction and gastrointestinal symptoms,COVID-19-induced autonomic effects significantly impact the patient's condition,general health,prognosis,and quality of life.Early diagnosis and proper recognition are crucial for improving outcomes.It is important to consider the differential diagnosis,as these symptoms may be induced by diseases other than COVID-19-induced autonomic dysfunction.Treating this dysfunction can be a challenging task.CONCLUSION To ensure the best possible outcomes for COVID-19 patients,it is essential to take a multidisciplinary approach involving providing supportive care,treating the underlying infection,managing dysfunction,monitoring for complications,and offering nutritional support.Close monitoring of the patient's condition is crucial,and prompt intervention should be taken if necessary.Furthermore,conducting thorough research on the gastrointestinal autonomic dysfunction caused by COVID-19 is vital to manage it effectively. 展开更多
关键词 COVID-19 SARS-CoV-2 Gastrointestinal autonomic dysfunction Long COVID Post-COVID Autonomic nervous system
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Gastrointestinal dysfunction is associated with mortality in severe burn patients:a 10-year retrospective observational study from South China 认领 引用
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作者 Qiu-Lan He Shao-Wei Gao +5 位作者 Ying Qin Run-Cheng Huang Cai-Yun Chen Fei Zhou Hong-Cheng Lin Wen-Qi Huang 《Military Medical Research》 SCIE CAS CSCD 2023年第3期299-312,共14页
Background:Data on severe and extensive burns in China are limited,as is data on the prevalence of a range of related gastrointestinal(GI)disorders[such as stress ulcers,delayed defecation,opioid-related bowel immotil... Background:Data on severe and extensive burns in China are limited,as is data on the prevalence of a range of related gastrointestinal(GI)disorders[such as stress ulcers,delayed defecation,opioid-related bowel immotility,and abdominal compartment syndrome(ACS)].We present a multicentre analysis of coincident GI dysfunction and its effect on burn-related mortality.Methods:This retrospective analysis was conducted on patients with severe[≥20%total burn surface area(TBSA)]and extensive(>50%TBSA or>25%full-thickness TBSA)burns admitted to three university teaching institutions in China between January 1,2011 and December 31,2020.Both 30-and 90-day mortality were assessed by collating demographic data,burn causes,admission TBSA,%full-thickness TBSA,Baux score,Abbreviated Burn Severity Index(ABSI)score,and Sequential Organ Failure Assessment(SOFA)score,shock at admission and the presence of an inhalation injury.GI dysfunction included abdominal distension,nausea/vomiting,diarrhoea/constipation,GI ulcer/haemorrhage,paralytic ileus,feeding intolerance and ACS.Surgeries,length of intensive care unit(ICU)stay,pain control[in morphine milligram equivalents(MME)]and overall length of hospital stay(LOHS)were recorded.Results:We analyzed 328 patients[75.6%male,mean age:(41.6±13.6)years]with a median TBSA of 62.0%(41.0%–80.0%);256(78.0%)patients presented with extensive burns.The 90-day mortality was 23.2%(76/328),with 64(84.2%)of these deaths occurring within 30 d and 25(32.9%)occurring within 7 d.GI dysfunction was experienced by 45.4%of patients and had a significant effect on 90-day mortality[odds ratio(OR)=14.070,95%confidence interval(CI)5.886–38.290,P<0.001].Multivariate analysis showed that GI dysfunction was associated with admission SOFA score and%full-thickness TBSA.Overall,88.2%(67/76)of deceased patients had GI dysfunction[hazard ratio(HR)for death of GI dysfunction=5.951],with a survival advantage for functional disorders(diarrhoea,constipation,or nausea/vomiting)over GI ulcer/haemorrhage(P<0.001).Conclusion:Patients with severe burns have an unfavourable prognosis,as nearly one-fifth died within 90 d.Half of our patients had comorbidities related to GI dysfunction,among which GI ulcers and haemorrhages were independently correlated with 90-day mortality.More attention should be given to severe burn patients with GI dysfunction. 展开更多
关键词 Severe burn Gastrointestinal dysfunction Mortality Sepsis Gastrointestinal haemorrhage Continuous analgesia
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Novel insights into autophagy in gastrointestinal pathologies,mechanisms in metabolic dysfunction-associated fatty liver disease and acute liver failure 认领 引用 被引量：3
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作者 Tsvetelina Velikova Milena Gulinac 《World Journal of Gastroenterology》 SCIE CAS 2024年第27期3273-3277,共5页
In this editorial,we comment on three articles published in a recent issue of World Journal of Gastroenterology.There is a pressing need for new research on autophagy's role in gastrointestinal(GI)disorders,and al... In this editorial,we comment on three articles published in a recent issue of World Journal of Gastroenterology.There is a pressing need for new research on autophagy's role in gastrointestinal(GI)disorders,and also novel insights into some liver conditions,such as metabolic dysfunction-associated fatty liver disease(MAFLD)and acute liver failure(ALF).Despite advancements,understanding autophagy's intricate mechanisms and implications in these diseases remains incomplete.Moreover,MAFLD's pathogenesis,encompassing hepatic steatosis and metabolic dysregulation,require further elucidation.Similarly,the mechanisms underlying ALF,a severe hepatic dysfunction,are poorly understood.Innovative studies exploring the interplay between autophagy and GI disorders,as well as defined mechanisms of MAFLD and ALF,are crucial for identifying therapeutic targets and enhancing diagnostic and treatment strategies to mitigate the global burden of these diseases. 展开更多
关键词 Gastrointestinal diseases Autophagy Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Silent information regulator sirtuin 1 Acute liver failure
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Effect of self-made exhaust plaster on patients with gastrointestinal dysfunction after gynecological operation 认领 引用
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作者 Wen-Ming Cao Xiu-Rong Wang Xiao-Xia Wang 《Psychosomatic Medicine Research》 2020年第2期54-59,共6页
Objective:To explore the effect of self-made exhaust patch(SMEP)on gastrointestinal dysfunction after gynecological operation.Methods:A total of 200 patients with gynecological operation in the gynecological ward of S... Objective:To explore the effect of self-made exhaust patch(SMEP)on gastrointestinal dysfunction after gynecological operation.Methods:A total of 200 patients with gynecological operation in the gynecological ward of Shandong Changle People's Hospital were randomly divided into the control group(n=100)and the treatment group(n=100).The recovery time of bowel sounds,the time of first anal exhaust,the duration of abdominal distention,the duration of abdominal pain,the incidence of abdominal distention and abdominal pain and linical efficacy of SMEP were observed.Results:Compared with the control group,the recovery time of gastrointestinal function and the first anal exhaust time in the treatment group were shorter;the duration of abdominal distention and abdominal pain in the treatment group were shorter than those in the control group(P<0.05);Cure rate of abdominal distention in the treatment is 62.5%and cure rate of abdominal pain in the treatment is 60%within 72 hours after operation,which is higher than that in the control group(44.%,45.9%).Conclusion:The results showed that the self-made exhaust patch can improve the clinical symptoms of patients after gynecological abdominal surgery,and the self-made exhaust patch had a significant effect on gastrointestinal dysfunction after gynecological surgery,which was worthy of clinical promotion. 展开更多
关键词 Self-made exhaust patch Gynecological operation Gastrointestinal dysfunction Abdominal distention
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A randomized placebo-controlled trial of Chinese medicine acupoint application on gastrointestinal dysfunction after appendectomy 认领 引用
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作者 Hong Chen Yi-Yuan Liu +6 位作者 Yu-Tao Wang Cheng-Cheng Yang Xiu-Qin Xu Hai-Rong Hu Yun-Lan Jiao Xing-Tong Bao Ling Tang 《TMR Non-Drug Therapy》 2020年第4期158-164,共7页
Background:Gastrointestinal dysfunction is one of the common complications of appendectomy,which seriously affects the postoperative recovery and clinical prognosis.Through traditional Chinese medicine acupoint applic... Background:Gastrointestinal dysfunction is one of the common complications of appendectomy,which seriously affects the postoperative recovery and clinical prognosis.Through traditional Chinese medicine acupoint application is suggested for managing postoperative gastrointestinal dysfunction,supporting evidence is weak.Here,the prospective randomized placebo-controlled study was designed to provide high-level evidence regarding whether traditional Chinese medicine acupoint application is effective on the gastrointestinal dysfunction after appendectomy.Methods:A total of 60 patients who underwent appendectomy in Dongfang Hospital Beijing University of Chinese Medicine(Beijing,China)from November 2016 to December 2017 were selected as study objects and randomly divided into control group(n=30)and observation group(n=30).Based on routine postoperative care,the acupoints Zusanli(ST36)and Yongquan(KI1)were selected.The control group was given acupoint application of traditional Chinese medicine placebo and the observation group was given acupoint application of clinical empirical Chinese medicine called Wentongliqi prescription.The course of treatment was performed on the 1st,2nd,and 3rd days after appendectomy,once a day and 4 hours each time.The primary outcome includes the time until the recovery time of bowel sounds(h),the first postoperative flatus(h)and first bowel movement time(h)on the 1st,2nd,and 3rd days after appendectomy.The secondary outcome includes clinical symptom score,life ability score and adverse reactions were observed and recorded on the 1st,2nd,and 3rd days after appendectomy.Results:After treatment,the recovery time of intestinal sound in the observation group was earlier than that in the control group(P0.05).Conclusion:Acupoint application therapy has limited effect on the recovery of gastrointestinal dysfunction after appendectomy.Further study with large sample size is needed to confirm its therapeutic effects. 展开更多
关键词 Appendicitis Gastrointestinal dysfunction Acupoint sticking therapy Randomized controlled clinical trials Curative effect Security
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Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients 认领 引用 被引量：3
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作者 Weijie Xue Masaki Honda Taizo Hibi 《World Journal of Gastroenterology》 SCIE CAS 2023年第15期2283-2293,共11页
Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a major global public health event,resulting in a significant social and economic burden.Alth... Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a major global public health event,resulting in a significant social and economic burden.Although COVID-19 was initially characterized as an upper respiratory and pulmonary infection,recent evidence suggests that it is a complex disease including gastrointestinal symptoms,such as diarrhea,nausea,and vomiting.Moreover,it remains unclear whether the gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or are the result of systemic immune activation and subsequent dysregulation of homeostatic mechanisms.This review provides a brief overview of the mechanisms by which SARS-CoV-2 disrupts the integrity of the gastrointestinal barrier including the mechanical barrier,chemical barrier,microbial barrier,and immune barrier. 展开更多
关键词 Gastrointestinal barrier dysfunction SARS-CoV-2 COVID-19 Angiotensinconverting enzyme 2 Microbiome Immune cells
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