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Enhanced neurogenesis after ischemic stroke:The interplay between endogenous and exogenous stem cells 认领 引用 被引量：3
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作者 Ruxu Geng Yuhe Wang +2 位作者 Renzhi Wang Jun Wu Xinjie Bao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期212-223,共12页
Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within t... Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within the ischemic brain,these mechanisms are often insufficient to restore neuronal functionality.This has led to intensive investigation into the use of exogenous stem cells as a potential therapeutic option.This comprehensive review outlines the ontogeny and mechanisms of activation of endogenous neural stem cells within the adult brain following ischemic events,with focus on the impact of stem cell-based therapies on neural stem cells.Exogenous stem cells have been shown to enhance the proliferation of endogenous neural stem cells via direct cell-tocell contact and through the secretion of growth factors and exosomes.Additionally,implanted stem cells may recruit host stem cells from their niches to the infarct area by establishing so-called“biobridges.”Furthermore,xenogeneic and allogeneic stem cells can modify the microenvironment of the infarcted brain tissue through immunomodulatory and angiogenic effects,thereby supporting endogenous neuroregeneration.Given the convergence of regulatory pathways between exogenous and endogenous stem cells and the necessity for a supportive microenvironment,we discuss three strategies to simultaneously enhance the therapeutic efficacy of both cell types.These approaches include:(1)co-administration of various growth factors and pharmacological agents alongside stem cell transplantation to reduce stem cell apoptosis;(2)synergistic administration of stem cells and their exosomes to amplify paracrine effects;and(3)integration of stem cells within hydrogels,which provide a protective scaffold for the implanted cells while facilitating the regeneration of neural tissue and the reconstitution of neural circuits.This comprehensive review highlights the interactions and shared regulatory mechanisms between endogenous neural stem cells and exogenously implanted stem cells and may offer new insights for improving the efficacy of stem cell-based therapies in the treatment of ischemic stroke. 展开更多
关键词 brain-derived neurotrophic factor endogenous neuroregeneration exosomes hydrogels ischemic stroke mesenchymal stem cells neural stem cells neurogenesis stem cell transplantation
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Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer's disease 认领 引用 被引量：4
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作者 Li Zeng Kaiyue Zhao +5 位作者 Jianghong Liu Mimin Liu Zhongdi Cai Ting Sun Zhuorong Li Rui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期392-405,共14页
Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The... Long noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer's disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated. The long noncoding RNA growth arrest-specific 5(GAS5) is a member of the 5′-terminal oligopyrimidine gene family that may be involved in neurological disorders, but its role in Alzheimer's disease remains unclear. This study aimed to investigate the function of GAS5 and construct a GAS5-associated competitive endogenous RNA network comprising potential targets. RNA sequencing results showed that GAS5 was upregulated in five familial Alzheimer's disease(5×FAD) mice, APPswe/PSEN1dE9(APP/PS1) mice, Alzheimer's disease-related APPswe cells, and serum from patients with Alzheimer's disease. Functional experiments with targeted overexpression and silencing demonstrated that GAS5 played a role in cognitive dysfunction and multiple Alzheimer's disease-associated pathologies, including tau hyperphosphorylation, amyloid-beta accumulation, and neuronal apoptosis. Mechanistic studies indicated that GAS5 acted as an endogenous sponge by competing for microRNA-23b-3p(miR-23b-3p) binding to regulate its targets glycogen synthase kinase 3beta(GSK-3β) and phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in an Argonaute 2-induced RNA silencing complex(RISC)-dependent manner. GAS5 inhibited miR-23b-3p-mediated GSK-3β and PTEN cascades with a feedforward PTEN/protein kinase B(Akt)/GSK-3β linkage. Furthermore, recovery of GAS5/miR-23b-3p/GSK-3β/PTEN pathways relieved Alzheimer's disease-like symptoms in vivo, indicated by the amelioration of spatial cognition, neuronal degeneration, amyloid-beta load, and tau phosphorylation. Together, these findings suggest that GAS5 promotes Alzheimer's disease pathogenesis. This study establishes the functional convergence of the GAS5/miR-23b-3p/GSK-3β/PTEN pathway on multiple pathologies, suggesting a candidate therapeutic target in Alzheimer's disease. 展开更多
关键词 Alzheimer's disease amyloid-beta peptide accumulation cognitive dysfunction competitive endogenous RNA glycogen synthase kinase 3beta lncRNA growth arrest-specific 5 microRNA-23b-3p neuronal apoptosis phosphatase and tensin homologue deleted on chromosome 10 tau phosphorylation
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Evolution Characteristics and Driving Mechanism of‘Bottom-up’and‘Top-down’Endogenous Automobile Industry Clusters:A Comparative Study in Taizhou and Wuhu,China 认领 引用 被引量：1
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作者 JIANG Haining ZHANG Jun +1 位作者 CHEN Jiaqi JIN Xingxing 《Chinese Geographical Science》 SCIE CAS CSCD 2026年第1期34-49,共16页
Bottom-up and top-down endogenous automobile clusters exhibit distinct evolutionary traits and driving mechanisms,yet their comparative analysis remains understudied.Therefore,using Taizhou automobile industry cluster... Bottom-up and top-down endogenous automobile clusters exhibit distinct evolutionary traits and driving mechanisms,yet their comparative analysis remains understudied.Therefore,using Taizhou automobile industry cluster(TAIC)and Wuhu automobile industry cluster(WAIC)as cases,using historical statistical data and field interview data from the 1980s to 2023,combined with qualitative research methods of thematic and diachronic analysis,and quantitative research methods of social network analysis,we compare both endogenous automobile clusters’evolutionary traits and driving mechanisms.The results confirm both clusters undergo multi-scale spatial reconfiguration,organizational complexification,and intelligent networking technological transformation,yet diverge fundamentally:TAIC evolves through market-driven progressive expansion,transitioning from single to dual-core structures via private enterprise networking,with innovation following market-integrated logic and institutional thickness built on demand-driven evolution.Conversely,WAIC follows planned expansion,maintaining state-led hierarchical single-core stability through policy-driven breakthrough innovation and supply-dominated institutional construction-though both ultimately require formal-informal system synergy.Their coevolution is driven by dynamic interactions of path dependence(weakening influence),learning-innovation(strengthening influence),and relationship selection(inverted U-shaped trajectory),with divergent development paths rooted in TAIC’s grassroots self-organization genes versus WAIC’s top-level design genes,amplified by core enterprises’strategic disparities.The research findings can not only provide decision-making support for China’s industrial upgrading,but also contribute China’s insights to global economic governance. 展开更多
关键词 endogenous automobile industrial clusters evolutionary characteristics driving mechanism Taizhou Wuhu China
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Manipulating Interphase Chemistry by Endogenous Doping Toward High‑Performance Hard Carbon Anodes for Sodium‑Ion Batteries 认领 引用
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作者 Hang Li Yuan Zhou +7 位作者 Yutian Yang Yining Chen Yuying Zhang Zhe Wang Quan Zong Guozhao Fang Shuang Zhou Anqiang Pan 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第8期585-602,共18页
The practical of hard carbon(HC)anodes in sodium-ion batteries is primarily limited by their unsatisfactory initial coulombic efficiency(ICE),cycling stability and rate performance,which are closely related to their i... The practical of hard carbon(HC)anodes in sodium-ion batteries is primarily limited by their unsatisfactory initial coulombic efficiency(ICE),cycling stability and rate performance,which are closely related to their interphase chemistry and microstructure.Herein,a unique manipulating interphase chemistry strategy by endogenous N/S doping is proposed to simultaneously achieve the both issues.Specifically,a series of reducing sugars and amino acid have been proven to trigger the Maillard reaction,thereby enabling endogenous N/S doping and microstructural design for HC anodes.Endogenous doping facilitates the formation of an inorganic-enriched solid-electrolyte interface(SEI)layer on cycled HC,which can effectively accelerate ion transport kinetics and reduce side effects for enhanced rate,ICE,cycling performance and reversible capacity.Meanwhile,the increase in the number of closed pores boosts both the platform capacity and cycling stability of HC.Consequently,the features HC anodes demonstrate a splendid reversible capacity(363 mAh g-1 at 0.05 A g-1),superior cycling performance(over 2500 cycles with 79%retention at 5.0 A g-1)and adequate ICE(89%).The assembled full cell with Na3V2(PO4)3 cathode exhibits splendid cycling stability over 700 cycles with capacity retention of 89.2%at 1 C.Surprisingly,the pouch cell with high cathode mass loading of 20.7 mg cm−1 maintains 98.1%capacity retention after 175 cycles at 1 C.This strategy provides new ideas and insights for the design and screening of high-performance HC anodes. 展开更多
关键词 Hard carbon Sodium-ion batteries Maillard reaction Endogenous doping Micropore structure Solid-electrolyte interface layer
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Biomaterial gels drive endogenous neurogenesis to support functional recovery after adult traumatic cortical injury 认领 引用
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作者 Jinting Wu Peng Hao +5 位作者 Hongmei Duan Wen Zhao Yudan Gao Zhiqiang Cui Zhaoyang Yang Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4290-4296,共7页
Activation and neuronal differentiation of endogenous neural stem/progenitor cells within the hippocampal neurogenic niche(a neurogenic region) of the adult mammalian brain are considered potential bases for restorati... Activation and neuronal differentiation of endogenous neural stem/progenitor cells within the hippocampal neurogenic niche(a neurogenic region) of the adult mammalian brain are considered potential bases for restoration of cognitive and memory functions.However,following traumatic cortical brain injury(i.e.,injuries in a non-neurogenic region),the local microenvironment becomes hostile due to the presence of inhibitory factors such as inflammation,edema,and hypoxic-ischemic stress.These conditions hinder the migration and subsequent neuronal differentiation of activated neural stem/progenitor cells into the injured cortex.Numerous recent studies have confirmed that biomaterials can improve the microenvironment of the injured area and promote nerve regeneration.In this study,we report the findings obtained by injecting a biodegradable chitosan-gelatin-collagen gel into the cortical lesion area.We observed that the chitosan-gelatin-collagen gel established a permissive microenvironment for neural repair by suppressing inflammation and scar infiltration while promoting neovascularization.Thus,it enabled activated endogenous “seed” cells,i.e.,neural stem/progenitor cells,to migrate into the cortical lesion area and generate new neurons and thereby facilitate functional recovery.These findings represent a novel biomaterial-based therapeutic strategy for the treatment of traumatic cortical brain injury,stroke,and other neurological disorders. 展开更多
关键词 biomaterial gel chitosan-gelatin-collagen gel endogenous neural stem cell functional recovery newborn neuron traumatic cortical brain injury
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Rictor/mTORC2 signaling pathway protects endogenous neural stem cells to promote recovery after spinal cord injury 认领 引用
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作者 Kuileung Tong Shiming Li +4 位作者 Guoliang Chen Dacheng He Chengkai Lin Yuhang Li Ningning Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4367-4377,共11页
Although endogenous neural stem cells represent a promising target for noninvasive spinal cord injury repair,inflammatory lesion environments frequently trigger their death.Our prior work identified necroptosis as a k... Although endogenous neural stem cells represent a promising target for noninvasive spinal cord injury repair,inflammatory lesion environments frequently trigger their death.Our prior work identified necroptosis as a key death pathway for endogenous neural stem cells migrating to spinal cord injury lesions.Rapamycin-insensitive companion of mTOR(Rictor;a core component of the mechanistic target of rapamycin complex 2[mTORC2]complex)regulates neural stem cell self-renewal and differentiation,and our preliminary data implicate it in spinal cord injury repair;however,its role in promoting endogenous neural stem cell survival post-spinal cord injury remains unclear.Here,we generated conditional endogenous neural stem cell-specific Rictor knockout mice using the Cre-loxP system.Although the endogenous neural stem cell-specific Rictor knockout mice displayed normal baseline spinal cord morphology and function,they exhibited impaired functional recovery after spinal cord injury compared with wild-type controls.This deficit correlated with elevated inflammatory responses and the increased susceptibility of endogenous neural stem cells to necroptosis.Mechanistically,lentiviral-mediated Rictor knockdown in neural stem cells in vitro impaired lysosomal function,leading to heightened sensitivity to tumor necrosis factor-alpha-and lipopolysaccharide-induced necroptosis.Collectively,these findings indicate that Rictor/mTORC2 signaling protects endogenous neural stem cells against receptor-interacting protein kinase 1-mediated necroptosis following spinal cord injury.Consequently,the modulation of intrinsic Rictor activity represents a potential therapeutic strategy to enhance endogenous neural stem cell survival and functional recovery post-spinal cord injury. 展开更多
关键词 endogenous neural stem cell glial scar inflammation intracellular Ca2+ lysosome mTORC2 necroptosis Rictor RIPK1 spinal cord injury
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Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression 认领 引用
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作者 Jin-Jun Ding Xiao-Li Liu +11 位作者 Ang Li Yi-Yao Liang Yu-Bo Wang Xiao-Na Zhu Jie Li Jie Weng Lan Yan Wen-Wen Duan Zi-Chen Zhang Ti-Fei Yuan Xiao-Yun Guo Dong-Sheng Zhou 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第5期1177-1182,共6页
Dear Editor,Non-suicidal self-injury(NSSI)refers to the intentional,self-inflicted damage of body tissues in the absence of suicidal intent and represents a highly prevalent and clinically significant behavioral issue... Dear Editor,Non-suicidal self-injury(NSSI)refers to the intentional,self-inflicted damage of body tissues in the absence of suicidal intent and represents a highly prevalent and clinically significant behavioral issue among adolescents[1]. 展开更多
关键词 adolescents non suicidal self injury self injury severity comorbid depression Serum endogenous opioid levels behavioral issue
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Generalized Kennedy receivers enhanced CV-QKD in turbulent channels for endogenous security of space-air-ground integrated network 认领 引用
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作者 Shouye Miao Mugen Peng +3 位作者 Renzhi Yuan Bin Cao Mufei Zhao Zhifeng Wang 《Digital Communications and Networks》 SCIE EI CSCD 2026年第2期332-342,共11页
Endogenous security in next-generation wireless communication systems attracts increasing attentions in recent years.A typical solution to endogenous security problems is the Quantum Key Distribution(QKD),where uncond... Endogenous security in next-generation wireless communication systems attracts increasing attentions in recent years.A typical solution to endogenous security problems is the Quantum Key Distribution(QKD),where unconditional security can be achieved thanks to the inherent properties of quantum mechanics.Continuous Variable-Quantum Key Distribution(CV-QKD)enjoys high Secret Key Rate(SKR)and good compatibility with existing optical communication infrastructure.Traditional CV-QKD usually employ coherent receivers to detect coherent states,whose detection performance is restricted to the standard quantum limit.In this paper,we employ a generalized Kennedy receiver called CD-Kennedy receiver to enhance the detection performance of coherent states in turbulent channels,where Equal-Gain Combining(EGC)method is used to combine the output of CD-Kennedy receivers.Besides,we derive the SKR of a post-selection based CV-QKD protocol using both CD-Kennedy receiver and homodyne receiver with EGC in turbulent channels.We further propose an equivalent transmittance method to facilitate the calculation of both the Bit-Error Rate(BER)and SKR.Numerical results show that the CD-Kennedy receiver can outperform the homodyne receiver in turbulent channels in terms of both BER and SKR performance.We find that BER and SKR performance advantage of CD-Kennedy receiver over homodyne receiver demonstrate opposite trends as the average transmittance increases,which indicates that two separate system settings should be employed for communication and key distribution purposes.Besides,we also demonstrate that the SKR performance of a CD-Kennedy receiver is much robust than that of a homodyne receiver in turbulent channels. 展开更多
关键词 CV-QKD Endogenous security Generalized Kennedy receiver Space-air-ground integrated network Turbulent channels
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Defense hardening of electricity-hydrogen networks for extreme weather:A risk limitation approach with endogenous uncertainties 认领 引用
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作者 Sicheng Liu Bo Yang +4 位作者 Xin Li Xu Yang Zhaojian Wang Dafeng Zhu Xinping Guan 《Cyber-Physical Energy Systems》 2026年第1期42-52,共11页
Defense hardening can effectively enhance the resilience of distribution networks against extreme weather events.Currently,most existing hardening strategies focus on reducing load-shedding.However,for electricity-hyd... Defense hardening can effectively enhance the resilience of distribution networks against extreme weather events.Currently,most existing hardening strategies focus on reducing load-shedding.However,for electricity-hydrogen distribution networks(EHDNs),controlling hydrogen leakage risk is crucial to preventing severe incidents,such as explosions.This paper proposes an optimal hardening strategy for EHDNs against extreme weather,aiming to minimize load shedding while limiting the leakage risk of hydrogen pipelines.Specifically,improved endogenous uncertainty models are developed to characterize failure probabilities,enhancing the representation of failure correlations under the combined influence of both disaster intensity and hardening.Then,to derive the optimal hardening strategy,the failure models are integrated into a two-stage distributionally robust optimization incor-porating a hydrogen leakage chance constraint(HLCC)with endogenous uncertainties.To efficiently handle the HLCC under endogenous discrete uncertainties,a second-order cone transformation is introduced.Moreover,to address the intractable inverse of the second-order moment under the proposed endogenous uncertainties,lifted variables are adopted to refine the main-cross moments.These reformulate the hardening problem as a two-stage mixed-integer second-order-cone programming problem,which is finally solved by the column-and-constraint generation algorithm.Case studies demonstrate the effectiveness of the proposed method. 展开更多
关键词 Electricity-hydrogen distribution network Resilience enhancement Defense hardening Endogenous uncertainties Risk control
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LncRNA MALAT1 as a Competitive Endogenous RNA in Osteoarthritis:Mechanisms and Therapeutic Prospects 认领 引用
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作者 Junhao Hu 《Journal of Clinical and Nursing Research》 2026年第3期401-409,共9页
Osteoarthritis(OA)is a complex degenerative joint disease characterized by articular cartilage degeneration,synovial inflammation,and osteophyte formation,with its exact pathogenesis not yet fully elucidated.In recent... Osteoarthritis(OA)is a complex degenerative joint disease characterized by articular cartilage degeneration,synovial inflammation,and osteophyte formation,with its exact pathogenesis not yet fully elucidated.In recent years,competing endogenous RNA(ceRNA)regulatory networks,particularly the role of long non-coding RNAs(LncRNAs)within them,have garnered increasing attention.This review focuses on LncRNA MALAT1,summarizing its ceRNA mechanism in the initiation and progression of OA.The article systematically elaborates on how MALAT1 acts as a molecular sponge to adsorb specific microRNAs(miRNAs),thereby relieving the inhibition of downstream target genes,and consequently regulating key pathological processes such as chondrocyte metabolism,extracellular matrix homeostasis,inflammatory response,and cell apoptosis.Furthermore,this review summarizes the potential value and latest research progress in targeting the MALAT1-ceRNA axis for early OA diagnosis,disease monitoring,and the development of novel therapeutic strategies,aiming to provide a new theoretical basis and perspective for the precise diagnosis and treatment of OA. 展开更多
关键词 Osteoarthritis Competing endogenous RNA LncRNA MALAT1 Chondrocytes ceRNA network Molecular mechanism
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Role of endogenous wheat enzymes on gluten cross-linking and dough and bread properties:a review 认领 引用
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作者 Ying Liang Chunlei Zheng +3 位作者 Yaping Zhang Hao Liu Penghui Zhang Jinshui Wang 《Food Innovation and Advances》 2025年第3期321-333,共13页
The quality of wheat-based products is significantly influenced by the structure and properties of gluten,and these are affected by various endogenous enzymes.However,the specific mechanisms of these enzymes,such as s... The quality of wheat-based products is significantly influenced by the structure and properties of gluten,and these are affected by various endogenous enzymes.However,the specific mechanisms of these enzymes,such as sulfhydryl oxidase,protein disulfide isomerase,ascorbate oxidase,and dehydroascorbate reductase have not been well studied.The role of these enzymes in enhancing gluten network formation and dough properties is not yet fully understood.This review examines the types,structures,and mechanisms of these key enzymes,with a focus on their roles in promoting disulfide bond formation and improving dough rheology and bread quality.By elucidating the mechanisms through which these enzymes directly or indirectly influence the structure,function,and physicochemical properties of gluten proteins,this review provides critical insights that advance understanding of gluten crosslinking and lay the groundwork for practical strategies to enhance the quality and safety of wheat-based products in food processing. 展开更多
关键词 endogenous enzymes sulfhydryl oxidase ascorbate oxidase endogenous enzymeshoweverthe protein disulfide isomerase sulfhydryl oxidaseprotein disulfide isomeraseascorbate oxidaseand dehydroascorbate reductase enhancing gluten
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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex 认领 引用 被引量：5
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作者 Yan Li Peng Hao +6 位作者 Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第10期2923-2937,共15页
The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne... The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries. 展开更多
关键词 adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation
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Mild deficit irrigation delays flag leaf senescence and increases yield in drip-irrigated spring wheat by regulating endogenous hormones 认领 引用 被引量：1
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作者 Ziqiang Che Shuting Bie +4 位作者 Rongrong Wang Yilin Ma Yaoyuan Zhang Fangfang He Guiying Jiang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第8期2954-2973,共20页
Drought is one of the important stress factors affecting the growth and development processes of wheat in China's arid zones, which severely limits the yield. This study examined the impact of deficit irrigation o... Drought is one of the important stress factors affecting the growth and development processes of wheat in China's arid zones, which severely limits the yield. This study examined the impact of deficit irrigation on the flag leaf protection system and yield of drip-irrigated spring wheat during the growth stages in arid zones. In addition, this study aimed to determine the optimal water supply mode for efficient production under drip irrigation conditions and to provide technical support for water-saving and high-yield cultivation of drip-irrigated wheat. The experiment was conducted with a split plot design using the water-sensitive variety Xinchun 22(XC22) and the drought-tolerant variety Xinchun 6(XC6) as the main plots, while a fully irrigated control(CK, 75–80% FC, where FC is field water holding capacity), mild deficit(T1, 60–65% FC) and moderate deficit(T2, 45–50% FC) at the tillering stage, and mild deficit(J1, 60–65% FC) and moderate deficit(J2, 45–50% FC) at the jointing stage were used as the subplots. Systematic studies were conducted on the regulatory effects of deficit irrigation during the tillering and jointing stages on protective substances, membrane lipid metabolism, endogenous hormones in the flag leaf, and yield of spring wheat. Compared with treatments T2 and J2, treatments T1 and J1 were beneficial for increasing the activities of superoxide dismutase(SOD), peroxidase(POD), and catalase(CAT), the levels of proline(Pro), indole-3-acetic acid(IAA), and zeatin riboside(ZR), and the ratios IAA/abscisic acid(ABA), ZR/ABA, IAA/ZR, and(IAA+ZR)/ABA, while reducing the levels of hydrogen peroxide(H2O2), superoxide anion radicals(O2–·), malondialdehyde(MDA), phosphatidic acid(PA), free fatty acids(FFA), ABA, phospholipase D(PLD), and lipoxygenase(LOX), alleviating flag leaf senescence, and increasing yield. Under treatment T1, the SOD, POD, CAT, and Pro levels of flag leaves in XC6 were 11.14, 8.08, 12.98, and 3.66% higher than those of treatment CK, and under treatment J1, they were 6.43, 4.49, 7.36, and 2.50% higher than those of treatment CK. Under treatment T1 in XC6, the IAA, ZR level of the flag leaf, spike number, grains per spike, 1,000-grain weight and yield were 10.50, 5.79, 3.10, 8.84, 3.78, and 10.52% higher than those of treatment CK, and under treatment J1, they were 5.36, 3.94, 2.40, 3.72, 1.37, and 4.46% higher than those of treatment CK. Compared with XC22, XC6 was more conducive to the improvement of flag leaf protective substances, IAA, ZR, dry matter weight, yield components and yield. The correlation analysis showed significant positive correlations between IAA and ZR with SOD, POD, CAT, proline, and yield. IAA and ZR promoted the enhancement of protective enzyme activities, thereby clearing reactive oxygen species to cope with the oxidative stress caused by drought and achieve the effect of delaying senescence. Principal component analysis showed that yield components and dry matter weight, had direct effects on yield. Mild deficiency during the tillering stage without water stress in other stages could effectively optimize yield components, not only achieving high yield while increasing protective substances, but also reducing the reactive oxygen species content. This strategy can be recommended as a water-saving and high-yield production mode for drip irrigation of spring wheat in Xinjiang, China. 展开更多
关键词 spring wheat senescence protection system endogenous hormones yield
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Integrated Optimization Scheduling Model for Ship Outfitting Production with Endogenous Uncertainties 认领 引用 被引量：1
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作者 Lijun Liu Pu Cao +2 位作者 Yajing zhou Zhixin Long Zuhua Jiang 《哈尔滨工程大学学报（英文版）》 CSCD 2025年第1期194-209,共16页
Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan ... Ship outfitting is a key process in shipbuilding.Efficient and high-quality ship outfitting is a top priority for modern shipyards.These activities are conducted at different stations of shipyards.The outfitting plan is one of the crucial issues in shipbuilding.In this paper,production scheduling and material ordering with endogenous uncertainty of the outfitting process are investigated.The uncertain factors in outfitting equipment production are usually decision-related,which leads to difficulties in addressing uncertainties in the outfitting production workshops before production is conducted according to plan.This uncertainty is regarded as endogenous uncertainty and can be treated as non-anticipativity constraints in the model.To address this problem,a stochastic two-stage programming model with endogenous uncertainty is established to optimize the outfitting job scheduling and raw material ordering process.A practical case of the shipyard of China Merchants Heavy Industry Co.,Ltd.is used to evaluate the performance of the proposed method.Satisfactory results are achieved at the lowest expected total cost as the complete kit rate of outfitting equipment is improved and emergency replenishment is reduced. 展开更多
关键词 Ship outfitting Production scheduling Purchase planning Endogenous uncertainty Multistage stochastic programming
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An overview of the formation mechanisms of endogenous and exogenous N-nitrosamines in human diets 认领 引用
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作者 Fan Zhou Yuxuan Xie +4 位作者 Yu Wang Huayu Zhang Jun Wang Xiaobin Liao Chao Chen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第12期527-541,共15页
There are two formation routes of dietary N-nitrosamines:exogenous and endogenous formation.The formation of N-nitrosamines from either source requires precursors with a dialkylamine functional group and a nitrosating... There are two formation routes of dietary N-nitrosamines:exogenous and endogenous formation.The formation of N-nitrosamines from either source requires precursors with a dialkylamine functional group and a nitrosating agent.Precursors are supplied primarily by amine-rich foods and nitrosating agents are nitrite or its reaction products(N2O3 and NO+).Unprocessed fresh foods initially contain zero or only trace amounts of N-nitrosamines while significant amounts of N-nitrosamines can be generated during certain types of food processing.Cooking methods,pH,additives,and storage conditions can affect the formation of N-nitrosamines in foods.We analysed the formation mechanisms/pathways of the three most frequently detected N-nitrosamines in processed meats.Formation of endogenous N-nitrosamines is likely to be greater than that of exogenous N-nitrosamines.Nitrosating agents involved in the formation of endogenous N-nitrosamines are formed from nitrate in vegetables via the nitrate-nitrite-NO cycle.N-nitrosamines are produced in the human stomach and intestine but their formation mechanisms differ.We analysed the mechanism/pathway for the formation of N-nitrosotryptophan from tryptophan in the stomach.The formation of N-nitrosamines in the intestine includes both chemical and microbiological mechanisms.In addition to N-nitrosation,S-nitrosation also occurs in the human body.There is a competitive relationship between the two reactions,and S-nitrosation is more likely to occur in the healthy human body.This paper reviews the mechanisms and factors influencing the formation of exogenous and endogenous dietary N-nitrosamines,which illustrate the importance of microbial-mediated N-nitrosamine formation and the production of endogenous N-nitrosamines. 展开更多
关键词 N-nitrosamine Nitrosation Dietary Exogenous exposure Endogenous exposure
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Endogenous formation of Fe-bearing particles and their differentiation from exogenous exposure 认领 引用
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作者 Yuming Huang Lin Liu +6 位作者 Hang Yang Huixuan Yi Xiangyu Li Linqian Li Dawei Lu Qian Liu Guibin Jiang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第12期386-394,共9页
Accurately distinguishing between the endogenous formation and exogenous exposure of Fe-bearing particles(e.g.,magnetic Fe particles)within biological organisms is the prerequisite for scientifically evaluating their ... Accurately distinguishing between the endogenous formation and exogenous exposure of Fe-bearing particles(e.g.,magnetic Fe particles)within biological organisms is the prerequisite for scientifically evaluating their health risks.However,this remains a challenging task due to lacking the comprehensive understanding of the endogenous formation process of Fe-bearing particles.Here,we report the formation dynamics of Fe-bearing particles under conditions closely resembling actual physiological conditions,and compare the morphological and structural differences between endogenous and exogenous Fe-bearing particles.We find that Fe-bearing particles can indeed form under physiological conditions at 37℃.In this process,phosphate plays a crucial role in the oxidation and mineralization of iron ions.Moreover,endogenously formed Fe-bearing particles typically have a diameter of less than8 nm,and iron is the only metal element present.Therefore,we propose that Fe-bearing particles found in the body with a diameter larger than 8 nm are mainly derived from exogenous exposure.For Fe-bearing particles smaller than 8 nm,it is necessary to combine associated elements and crystal structure characteristics to distinguish between endogenous and exogenous sources.This study provides direct evidence from endogenous metabolism for tracing Fe-bearing particles,especially magnetic iron particles,within the human body. 展开更多
关键词 Magnetic iron particles(Fe-MPs) Endogenous formation Ferritin PM2.5
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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation 认领 引用
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作者 Joel Gruchot Laura Reiche +2 位作者 Andrew Chan Robert Hoepner Patrick Küry 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第3期813-814,共2页
Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.
关键词 endogenous inflammation Human
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Long Non-Coding RNA HOXA10-AS Promotes the Migration and Invasion of Glioblastoma Cells by Serving as a Competing Endogenous RNA for miR-99a-3p to Upregulate ITGB5 Expression 认领 引用
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作者 Yingjie Wang Wanlin Dong +4 位作者 Can Wang Zirui Li Yongqiang Wang Qi Li Cheng-Ya Dong 《Oncology Research》 SCIE 2025年第12期4093-4111,共19页
Objectives:Glioblastoma is a prevalent malignant brain tumor,and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear.Here,the function of HOXA10-AS in glioblastoma cell invasi... Objectives:Glioblastoma is a prevalent malignant brain tumor,and the actions of the long non-coding RNA HOXA10-AS in its invasion and migration remain unclear.Here,the function of HOXA10-AS in glioblastoma cell invasion and migration and associated mechanisms were investigated.Methods:HOXA10-AS was knocked down in glioblastoma cells,and Transwell and wound healing assays were conducted to elucidate its impacts on cell invasion and migration.Western blotting and quantitative reverse transcription polymerase chain reaction(qRTPCR)assessed HOXA10-AS’s impact on the epithelial-mesenchymal transition(EMT).Microarray analysis identified differentially expressed genes,complemented by bioinformatics approaches to explore potentialmolecular participants and pathways.Rescue experiments validated our findings.Results:HOXA10-AS knockdown significantly inhibits glioblastoma cell migration,invasion,and the EMT process.Specifically,HOXA10-AS siRNA transfection significantly reduced the migratory capacity of A172 cells by 50.5%and U251 cells by 61.4%,as well as their invasive capacities by 33.8%and 58.5%,respectively(all p<0.05).HOXA10-AS acts as anmiR-99a-3p sponge,and pathway analysis identified processes linked to tumorigenesis andmetastasis,alongwith nine hub genes.HOXA10-AS upregulates the expression of integrin subunit beta 5(ITGB5)through a competing endogenous RNAmechanism.Thereduced tumorigenic behavior of glioblastoma cells due toHOXA10-AS knockdown can be rescued by ITGB5 overexpression ormiR-99a-3p inhibitor.Conclusion:These results indicate thatHOXA10-AS promotes tumorigenic behavior in glioblastoma cells by regulating the EMT-like process and functioning as an miR-99a-3p sponge to modulate ITGB5 levels,providing insights into glioblastoma development and potential therapeutic targets. 展开更多
关键词 HOXA10-AS competing endogenous RNA migration bioinformatics analysis glioblastoma
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Circular RNA contributes to gastric cancer by targeting Wnt family member 2B as a competing endogenous RNA 认领 引用
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作者 Wei Bai Zong-Liang Guo +3 位作者 Jiang-Hong Guo Feng Li Peng Bu Juan Liu 《World Journal of Gastroenterology》 SCIE CAS 2025年第10期71-85,共15页
BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,thi... BACKGROUND As a non-coding RNA molecule,circular RNAs(circRNAs)have significant specificity,and existing data suggest a close relationship between them and the prognosis of patients with gastric cancer(GC).However,this mechanism has no evidence yet.This article explores the functions of hsa_circRNA_102415 in the malignant behavior and potential downstream signaling of GC cells.The chosen approach is loss of signal and functional gain.AIM To investigate and analyze the relationship between hsa_circRNA_102415 and GC and explore its specific role.Results provide reference for other researchers to develop targeted treatment plans.METHODS The gene expression omnibus(GEO)database can be used to obtain the microarray dataset GSE83521.Data were analyzed using the GEO2R tool to identify differences in circRNAs between normal and GC samples.Quantitative real-time polymerase chain reaction was used to detect differentially expressed genes in GC tissue samples and adjacent cancer tissue samples.GC cells were transfected with small interfering-hsa_circRNA_104415 and plasmid DNA(pcDNA)-hsa_ircRNA_102415.Multiple detection methods,such as Transwell and cell counting kit 8,were used to evaluate cellular physiological activities,including cell invasion and proliferation.The relationship between Wnt family members 2B,microRNA(miR)-4529-5p,etc.,including argonaute 2-RNA immunoprecipitation and luciferase reporter genes was analyzed.Rescue experiments were conducted to analyze and explore the relationship between the malignant behavior of GC cells and hsa_circRNA_102415.RESULTS GEO2R analysis confirmed that hsa_circRNA_102415 had significantly higher expression levels in disease tissues.hsa_circRNA_102415 and miR-4529-5p showed a negative correlation in disease cells,suggesting that hsa_circRNA_102415 upregulated WNT2B expression in GC cells as a competing endogenous RNA for miR-4529-5p.miR-4529-5p mimic or small interfering-WNT2B reversed the effects of pcDNA-hsa_circRNA_102415 or miR-4529-5p inhibitor on cell malignant functions.CONCLUSION miR-4529-5p was used to successfully activate the potential of WNT2B,clarify the role of hsa_circRNA_102415 in GC cells,and provide reference for other researchers to develop targeted treatment plans. 展开更多
关键词 Competing endogenous RNA Wnt family member 2B MicroRNA-4529-5p Circular RNAs Gastric cancer
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Development of an endogenous promoter-driven CRISPR/Cas9 system for genome editing in Fraxinus mandshurica 认领 引用
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作者 Shangzhu Gao Mengfan Zhao +5 位作者 Siyu Sun Xin Fan Jialin Yan Ying Xin Yaguang Zhan Fansuo Zeng 《Forestry Research》 2025年第1期170-184,共15页
CRISPR/Cas9-mediated genome editing has revolutionized tree improvement by enabling precise trait modification,accelerating breeding cycles,and enhancing forestry sustainability.Fraxinus mandshurica,valued for its des... CRISPR/Cas9-mediated genome editing has revolutionized tree improvement by enabling precise trait modification,accelerating breeding cycles,and enhancing forestry sustainability.Fraxinus mandshurica,valued for its desirable traits and adaptability,serves as a strategic focus for the National Reserve Forest Project(NRFP)and forestry germplasm resource breeding and quality improvement in China.Developing a species-specific genome editing system is crucial for valuable yet recalcitrant species like F.mandshurica.In this study,the development of a species-specific CRISPR/Cas9 platform is presented for F.mandshurica,which incorporates endogenous promoter engineering,sgRNA optimization,light quality modulation,and temperature control protocols to enhance genome editing efficiency.Truncated endogenous FmU6 promoter variants(FmU6-6-4 and FmU6-7-4)drove sgRNA expression at levels 3.36 and 3.11 times higher than that of the AtU6-26 promoter.The expression of Cas9 was controlled by the endogenous constitutive FmECP3 promoter,exhibiting an activity 5.48 times greater than the positive control.A highly active sgRNA4 targeting FmPDS1/2 was identified,demonstrating a cleavage efficiency of 36.10%.Heat treatment at 37℃ effectively increased the Cas9 cleavage efficiency to 7.77 times that observed at 22℃.Chimeric albino mutants with an editing efficiency of 18.2% were obtained through transient and stable transformations,combined with light quality optimization and heat treatment during different regeneration stages.The mutation types included nucleotide insertions,deletions,and substitutions,leading to early termination codons and truncated FmPDS1/2 protein.Additionally,mutations in FmPDS1/2 resulted in albino phenotypes and a reduction in chlorophyll content to 46.44%-58.88%.This optimized system provides a robust platform for functional genomics studies and trait improvement in F.mandshurica,with potential applications in forestry biotechnology. 展开更多
关键词 genome editing endogenous promoter enhancing forestry sustainabilityfraxinus mandshuricavalued CRISPR Cas national reserve forest project nrfp tree improvement Fraxinus mandshurica precise trait modificationaccelerating breeding cyclesand
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