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Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas 认领 引用 被引量：40
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作者 Yan Xin Xiao Ling Li +4 位作者 Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang 《World Journal of Gastroenterology》 SCIE CAS 2001年第1期53-59,共7页
AIM:To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.METHODS:Surgically resected speci... AIM:To reveal the correlation between the functional differentiation phenotypes of gastric carcinoma cells and the invasion and metastasis by a new way of cell-function classification.METHODS:Surgically resected specimens of 361 gastric carcinomas(GC)were investigated with enzyme-,mucin-,and tumor-related marker immunohistochemistry.According to the direction of cell-function differentiation,stomach carcinomas were divided into five functionally differentiated types.RESULTS:(1)Absorptive function differentiation type(AFDT):there were 82(22.7%)patients including 76(92.7%)aged 45 years.Sixty-nine(84.1%)cases belonged to the intestinal type.Thirty-eight(46.3%)expressed CD44v6 and 9(13.6%)of 66 male patients developed liver metastasis.The 5-year survival rate of patients in this group(58.5%)was higher than those with the other types(P【0.01).(2)Mucin secreting function differentiation type(MSFDT):54(15%)cases.Fifty-three(98.1%)tumors had penetrated the serosa,12(22.2%)expressed ER and 22(40.7%)expressed CD44v6.The postoperative 5-year survival rate was 28.6%.(3)Absorptive and mucin-producing function differentiation type(AMPFDT):there were 180(49.9%)cases,including 31(17.2%)aged younger than 45 years.The tumor was more common in women(62,34.4%,)and expressed more frequently estrogen receptors(ER)(129,81.7%)than other types(P【0.01).Ovary metastasis was found in 12(19.4%)out of 62 female subjects.The patients with this type GC had the lowest 5-year survival rate(24.7%)among all types.(4)Specific function differentiation type(SFDT):13(3.6%)cases.Nine(69.2%)tumors of this type derived from APUD system,the other 4(30.7%)were of different histological differentiation.Sixty per cent of the patients survived at least five years.(5)Non-function differentiation type(NFDT):32(8.9%)cases.Nineteen(59.4%)cases had lymph node metastases but no one with liver or ovary metastasis.The 5-year survival rate was 28.1%.CONCLUSION:This new cell-function classification of GC is helpful in indicating the characteristics of invasion and metastasis of GC with different cell-function differentiation phenotypes.Further study is needed to disclose the correlation between the cell-functional differentiation phenotypes and the relevant genotypes and the biological behavior of gastric carcinoma. 展开更多
关键词 stomach neoplasms celldifferentiation lymphatic metastasis _prognosis cell-function classification immunohistochemistry absorptive function differentiation type
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The biological function of type I receptors of bone morphogenetic protein in bone 认领 引用 被引量：11
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作者 Shuxian Lin Kathy KH Svoboda +1 位作者 Jian Q Feng Xinquan Jiang 《Bone Research》 SCIE CAS CSCD 2016年第2期63-71,共9页
Bone morphogenetic proteins （BMPs） have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serinehreonine kinase receptors （BMPRI and BMPRII）. In recent decade... Bone morphogenetic proteins （BMPs） have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serinehreonine kinase receptors （BMPRI and BMPRII）. In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2 （ALK2, also called type IA activin receptor）, activin- llke kinase 3 （ALK3, also called BMPRIA）, and activin-like kinase 6 （ALK6, also called BMPRIB）. The research areas covered include the current progress regarding the roles of these receptors during myogenesis, chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future. 展开更多
关键词 ALK The biological function of type I receptors of bone morphogenetic protein in bone type
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Disparities in tree mortality among plant functional types(PFTs)in a temperate forest:Insights into size-dependent and PFT-specific patterns 认领 引用 被引量：1
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作者 Man Hu Hang Shi +6 位作者 Rui He Bingbin Wen Haikun Liu Kerong Zhang Xiao Shu Haishan Dang Quanfa Zhang 《Forest Ecosystems》 SCIE CSCD 2024年第4期480-490,共11页
Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains incomplete.This s... Tree mortality significantly influences forest structure and function,yet our understanding of its dynamic patterns among a range of tree sizes and among different plant functional types(PFTs)remains incomplete.This study analysed size-dependent tree mortality in a temperate forest,encompassing 46 tree species and 32,565 individuals across different PFTs(i.e.,evergreen conifer vs.deciduous broadleaf species,shade-tolerant vs.shade-intolerant species).By employing all-subset regression procedures and logistic generalized linear mixed-effects models,we identified distinct mortality patterns influenced by biotic and abiotic factors.Our results showed a stable mortality patte rn in eve rgreen conifer species,contrasted by a declining pattern in deciduous broadleaf and shadetolerant,as well as shade-intolerant species,across size classes.The contribution to tree mortality of evergreen conifer species shifted from abiotic to biotic factors with increasing size,while the mortality of deciduous broadleaf species was mainly influenced by biotic factors,such as initial diameter at breast height(DBH)and conspecific negative density.For shade-tolerant species,the mortality of small individuals was mainly determined by initial DBH and conspecific negative density dependence,whereas the mortality of large individuals was subjected to the combined effect of biotic(competition from neighbours)and abiotic factors(i.e.,convexity and pH).As for shade-intolerant species,competition from neighbours was found to be the main driver of tree mortality throughout their growth stages.Thus,these insights enhance our understanding of forest dynamics by revealing the size-dependent and PFT-specific tree mortality patterns,which may inform strategies for maintaining forest diversity and resilience in temperate forest ecosystems. 展开更多
关键词 Size-dependent tree mortality Plant functional type Neighbourhood competition Topography variables Soil properties
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Classification of plant functional types based on the nutrition traits: a case study on alpine meadow community in the Zoigê Plateau 认领 引用 被引量：6
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作者 SHEN Song-tao ZHANG Shu-jie +1 位作者 FAN Min WANG Qing 《Journal of Mountain Science》 SCIE CSCD 2017年第10期2003-2012,共10页
The ecological concept of Plant Functional Types（PFTs）, which refers to the assemblage of plants with certain functional traits, has been introduced for the study of plant responses to the environment change and hum... The ecological concept of Plant Functional Types（PFTs）, which refers to the assemblage of plants with certain functional traits, has been introduced for the study of plant responses to the environment change and human disturbance. Taking the alpine meadow community in the Zoigê Plateau as a study case, this paper classified PFTs in terms of plant nutrition traits. The sequential results are as follows.（1） The main herbages in the Zoigê Plateau included 16 species in 5 families. Among the five families, Cyperaceae vegetation accounted for 81.37%of herbage area in total, while the remaining 4families occupied less than 20%. As for the species,Kobresia setchwanensis Hand.-Maizz. was dominant,accounting for 48.74% of the total area; while the remaining 51.26% was comprised of Polygonum viviparum L., Anaphalis fiavescens Hand.-Mazz.,Stipa aliena Keng and other species.（2） By using the Principal Component Analysis（PCA）, the assessment of herbages nutrition was carried out based on the comprehensive multi-index evaluation model.Polygonum viviparum L. had the highest nutritional value score（1.43）, and Stipa aliena Keng had the lowest（-1.40）. Nutritional value of herbage species had a significantly positive correlation with altitude（P＆lt;0.01） in the Zoigê Plateau.（3） Based on the nutritional values, herbages in the Zoigê Plateau could be grouped into 3 nutrition PFTs（high, medium and low） by using the Natural Breaks（Jenks） method. 展开更多
关键词 Plant functional types Nutritional value Forage resource management the Zoigê Plateau
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Effect of Implementing Ecosystem Functional Type Data in a Mesoscale Climate Model 认领 引用 被引量：1
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作者 Seung-Jae LEE E. Hugo BERBERY Domingo ALCARAZ-SEGURA 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2013年第5期1373-1386,共14页
In this paper, we introduce a new concept of land-surface state representation for southern South America, which is based on ＂functional＂ attributes of vegetation, and implement a new land-cover （Ecosystem Function... In this paper, we introduce a new concept of land-surface state representation for southern South America, which is based on ＂functional＂ attributes of vegetation, and implement a new land-cover （Ecosystem Functional Type, hereafter EFT） dataset in the Weather and Research Forecasting （WRF） model. We found that the EFT data enabled us to deal with functional attributes of vegetation and time-variant features more easily than the default land-cover data in the WRF. In order to explore the usefulness of the EFT data in simulations of surface and atmospheric variables, numerical simulations of the WRF model, using both the US Geological Survey （USGS） and the EFT data, were conducted over the La Plata Basin in South America for the austral spring of 1998 and compared with observations. Results showed that the model simulations were sensitive to the lower boundary conditions and that the use of the EFT data improved the climate simulation of 2-m temperature and precipitation, implying the need for this type of information to be included in numerical climate models. 展开更多
关键词 Ecosystem Functional Type WRF land cover climate simulation
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ORTHOGONAL POLYNOMIALS AND DETERMINANT FORMULAS OF FUNCTION-VALUED PADE-TYPE APPROXIMATION USING FOR SOLUTION OF INTEGRAL EQUATIONS 认领 引用 被引量：2
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作者 顾传青 潘宝珍 吴蓓蓓 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2006年第6期853-860,共8页
To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined. By means of the power series expansion of the s... To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined. By means of the power series expansion of the solution, this method can construct an approximate solution to solve the given integral equation. On the basis of the orthogonal polynomials, two useful determinant expressions of the numerator polynomial and the denominator polynomial for Padé-type approximation are explicitly given. 展开更多
关键词 generalized linear functional function-valued Padé-type approximation Fredholm integral equation orthogonal polynomial determinant formula
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RAZUMIKHIN-TYPE THEOREM FOR NEUTRAL STOCHASTIC FUNCTIONAL DIFFERENTIAL EQUATIONS WITH UNBOUNDED DELAY 认领 引用 被引量：8
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作者 吴付科 胡适耕 毛学荣 《Acta Mathematica Scientia》 SCIE CSCD 2011年第4期1245-1258,共14页
This paper establishes the Razumikhin-type theorem on stability for neutral stochastic functional differential equations with unbounded delay. To overcome difficulties from unbounded delay, we develop several differen... This paper establishes the Razumikhin-type theorem on stability for neutral stochastic functional differential equations with unbounded delay. To overcome difficulties from unbounded delay, we develop several different techniques to investigate stability. To show our idea clearly, we examine neutral stochastic delay differential equations with unbounded delay and linear neutral stochastic Volterra unbounded-delay-integro-differential equations. 展开更多
关键词 neutral stochastic functional differential equations Razumikhin-type theorem ψ γ stability exponential stability polynomial stability
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Approximation by modified Durrmeyer type Jakimovski-Leviatan operators 认领 引用
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作者 Qing-bo Cai Şule Yüksel Güngör +1 位作者 BayramÇekim Mehmet AliÖzarslan 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2025年第3期709-724,共16页
In the present paper,the modified Durrmeyer type Jakimovski-Leviatan operators are presented and their approximation properties are examined.It has shown that the new operators are the Gamma transform of the Jakimovsk... In the present paper,the modified Durrmeyer type Jakimovski-Leviatan operators are presented and their approximation properties are examined.It has shown that the new operators are the Gamma transform of the Jakimovski-Leviatan operators.The degree of approximation is given by the modulus of continuity.It has been stressed that,there are other operators having the same error estimation with the operators,arising from the Sz´asz-Durrmeyer operators.Then the degree of global approximation is obtained in a special Lipschitz type function space.Further,a Voronovskaja type asymptotic formula and Gr¨uss-Voronovskaja type theorem are given.The approximation with these operators is visualized with the help of error tables and graphical examples. 展开更多
关键词 modulus of continuity Appell polynomials Durrmeyer operators Jakimovski-Leviatan operators Lipschitz type function space
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HIGHER RADIAL DERIVATIVE OF BLOCH TYPE FUNCTIONS 认领 引用 被引量：6
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作者 李波 欧阳才衡 《Acta Mathematica Scientia》 SCIE 2002年第4期433-445,共13页
In this paper, The integral characterizations of alpha-Bloch (little alpha-Bloch) axe given in terms of higher radial derivative, and their characterizations of Caxleson type measure are obtained.
关键词 Bloch type function higher radial derivative Carleson type measure
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RAZUMIKHIN-TYPE THEOREMS OF NEUTRAL STOCHASTIC FUNCTIONAL DIFFERENTIAL EQUATIONS 认领 引用 被引量：2
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作者 周少波 胡适耕 《Acta Mathematica Scientia》 SCIE 2009年第1期181-190,共10页
The stability of stochastic functional differential equation with Markovian switching was studied by several authors,but there was almost no work on the stability of the neutral stochastic functional differential equa... The stability of stochastic functional differential equation with Markovian switching was studied by several authors,but there was almost no work on the stability of the neutral stochastic functional differential equations with Markovian switching.The aim of this article is to close this gap.The authors establish Razumikhin-type theorem of the neutral stochastic functional differential equations with Markovian switching,and those without Markovian switching. 展开更多
关键词 Markovian chain Razumikhin-type theorem neutral stochastic functional differential equation exponential stability
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K-Dimension and Hlder Exponent for Bush Type Fractal Functions 认领 引用
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作者 王宏勇 《Journal of Southwest Jiaotong University(English Edition)》 2006年第4期400-403,共4页
Bush type fractal functions were defined by means of the expression of Cantor series of real numbers. The upper and lower bound estimates for the K-dimension of such functions were given. In a typical case, the fracta... Bush type fractal functions were defined by means of the expression of Cantor series of real numbers. The upper and lower bound estimates for the K-dimension of such functions were given. In a typical case, the fractal dimensional relations in which the K-dimension equals the box dimension and packing dimension were presented; moreover, the exact Holder exponent were obtained for such Bush type functions. 展开更多
关键词 Bush type function Fractal function K-Dimension Holder exponent
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SUFFICIENT CONDITION FOR FUNCTIONS TO BE IN A CLASS OF MEROMORPHIC MULTIVALENT SAKAGUCHI TYPE SPIRAL-LIKE FUNCTIONS 认领 引用 被引量：1
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作者 Muhammad ARIF Janusz SOK Muhammad AYAZ 《Acta Mathematica Scientia》 SCIE CSCD 2014年第2期575-578,共4页
In this article, we define a subclass of meromorphic multivalent Sakaguchi type functions and obtain certain sufficient conditions for functions to be in this class. The main result presented here includes a number of... In this article, we define a subclass of meromorphic multivalent Sakaguchi type functions and obtain certain sufficient conditions for functions to be in this class. The main result presented here includes a number of consequences as its special cases. 展开更多
关键词 Sakaguchi type functions spirallike functions meromorphic functions
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Uniform persistence of multispecies ecological competition predator-pray system with Holling Ⅲ type functional response 认领 引用 被引量：1
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作者 LI Zhan LI Ling-xiao WANG Ke 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE 2008年第4期410-412,共3页
The main purpose of this paper is to study the persistence of the general multispecies competition predator-pray system with Holling Ⅲ type functional response. In this system, the competition among predator species ... The main purpose of this paper is to study the persistence of the general multispecies competition predator-pray system with Holling Ⅲ type functional response. In this system, the competition among predator species and among prey species are simultaneously considered. By using the comparison theory and qualitative analysis, the sufficient conditions for uniform strong persistence are obtained. 展开更多
关键词 competition predator-pray system Holling Ⅲ type functional response persistence
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SANDWICH-TYPE THEOREMS FOR MEROMORPHIC MULTIVALENT FUNCTIONS ASSOCIATED WITH THE LIU-SRIVASTAVA OPERATOR 认领 引用
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作者 Nak Eun Cho 《Acta Mathematica Scientia》 SCIE CSCD 2012年第3期929-941,共13页
The purpose of this article is to obtain some subordination and superordi- nation preserving properties of meromorphic multivalent functions in the punctured open unit disk associated with the Liu-Srivastava operator.... The purpose of this article is to obtain some subordination and superordi- nation preserving properties of meromorphic multivalent functions in the punctured open unit disk associated with the Liu-Srivastava operator. The sandwich-type results for these meromorphic multivalent functions are also considered. 展开更多
关键词 Subordination superordination meromorphic multivalent function Liu- Srivastava operator sandwich-type result
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The Existence and Non-Existence of Positive Steady State Solutions for a Cross-Diffusion Predator-Prey Model with Holling Type Ⅱ Functional Response 认领 引用
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作者 Shuping CAO Li-na ZHANG 《Journal of Mathematical Research with Applications》 CSCD 2021年第4期383-392,共10页
In this paper,we consider the positive steady state solutions of a predator-prey model with Holling type Ⅱfunctional response and cross-diffusion,where two cross-diffusion rates represent the tendency of prey to keep... In this paper,we consider the positive steady state solutions of a predator-prey model with Holling type Ⅱfunctional response and cross-diffusion,where two cross-diffusion rates represent the tendency of prey to keep away from its predator and the tendency of the predator to chase its prey,respectively.Applying the fixed point index theory,some sufficient conditions for the existence of positive steady state solutions are established.Furthermore,the non-existence of positive steady state solutions is studied. 展开更多
关键词 predator-prey model Holling typeⅡfunctional response cross-diffusion coexistence states
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APPROXIMATION OF CONVEX TYPE FUNCTION BY PARTIAL SUMS OF FOURIER SERIES 认领 引用
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作者 YuGuohua 《Applied Mathematics(A Journal of Chinese Universities)》 2004年第1期67-76,共10页
The concept of convex type function is introduced in this paper,from which a kin d of convex decomposition approach is proposed.As one of applications of this a pproach,the approximation of the convex type function by... The concept of convex type function is introduced in this paper,from which a kin d of convex decomposition approach is proposed.As one of applications of this a pproach,the approximation of the convex type function by the partial sum of its Fourier series is inves tigated.Moreover,the order of approximation is describe d with the 2th continuous modulus. 展开更多
关键词 Fourier series convex type function convex decomposition Riemann deriv ative continuous modulus approximation.
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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction 认领 引用 被引量：2
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作者 Soon Hyun Park Sung Woo Park +6 位作者 Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park 《Asian Journal of Andrology》 SCIE CAS CSCD 2015年第1期143-148,I0011,I0012,共6页
We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-wee... We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients. 展开更多
关键词 erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil
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THE CAUCHY TYPE INTEGRAL FOR M-ANALYTIC FUNCTION AND ITS APPLICATION 认领 引用 被引量：1
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作者 林伟 戴道清 《Acta Mathematica Scientia》 SCIE 1990年第2期149-166,共18页
In this paper, the Cauchy type integral for M-analytic function is investigated which is by definition the regular solution of the elliptic system f_x+Mf_y=0, where M is a constant m×m matrix without any real eig... In this paper, the Cauchy type integral for M-analytic function is investigated which is by definition the regular solution of the elliptic system f_x+Mf_y=0, where M is a constant m×m matrix without any real eigenvalues and f is an m×q matrix. 展开更多
关键词 Pr THE CAUCHY TYPE INTEGRAL FOR M-ANALYTIC FUNCTION AND ITS APPLICATION
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Impulsive Predator-Prey Dynamic Systems with Beddington-DeAngelis Type Functional Response on the Unification of Discrete and Continuous Systems 认领 引用 被引量：1
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作者 Ayse Feza Güvenilir Billur Kaymakcalan Neslihan Nesliye Pelen 《Applied Mathematics》 2015年第9期1649-1664,共16页
In this study, the impulsive predator-prey dynamic systems on time scales calculus are studied. When the system has periodic solution is investigated, and three different conditions have been found, which are necessar... In this study, the impulsive predator-prey dynamic systems on time scales calculus are studied. When the system has periodic solution is investigated, and three different conditions have been found, which are necessary for the periodic solution of the predator-prey dynamic systems with Beddington-DeAngelis type functional response. For this study the main tools are time scales calculus and coincidence degree theory. Also the findings are beneficial for continuous case, discrete case and the unification of both these cases. Additionally, unification of continuous and discrete case is a good example for the modeling of the life cycle of insects. 展开更多
关键词 Time Scales Calculus Predator-Prey Dynamic Systems Periodic Solutions Coincidence Degree Theory Beddington-DeAngelis Type Functional Response
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Algebraic Independence Measures for the Values of Mahler Type Functions 认领 引用
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作者 WANG Tian-qin LIU Hua-ke 《Chinese Quarterly Journal of Mathematics》 北大核心 2006年第4期567-576,共10页
In this paper, we give the algebraic independence measures for the values ofMahler type functions in complex number field and p-adic number field, respectively.
关键词 algebraic independence measure Mahler type function p-adic number field
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