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Lights for aging:Can photobiomodulation restore functionality in the cerebral networks of aged individuals? 认领 引用
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作者 Marjorie Dole John Mitrofanis 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期3991-3996,共6页
Of all our organs,the brain is particularly prone to aging.The neurons become increasingly more dysfunctional with age,leading to less efficient patterns of functional connectivity,not only within,but also between the... Of all our organs,the brain is particularly prone to aging.The neurons become increasingly more dysfunctional with age,leading to less efficient patterns of functional connectivity,not only within,but also between the different large-scale resting-state networks.Further,the aged brain shows weaker,less efficient patterns of activation when undertaking a particular task,such as a motor movement or recalling a memory.Quite remarkably,however,compensatory mechanisms do develop,where other brain regions are recruited to help perform the tasks.There is,however,much variability across different individuals in the ability to recruit such compensatory processes,and this has been referred to as cognitive reserve or resilience.In addition to these neuronal dysfunctions,the aged brain suffers from widespread inflammation.In terms of options to slow the aging process,there is nothing specific on offer,except for some recommendations to live a healthier life(e.g.,change in diet,more exercise,and cognitive training).In this narrative review,we explore the idea that the use of red and near infrared light,referred to often as photobiomodulation,can slow neuronal wear and tear,reduce inflammation,enhance the overall function of the cerebral networks,and improve the quality of life in aged individuals.We hypothesize that the application of these specific wavelengths of light has the potential to improve aged-induced cell dysfunction and death,leading to a restoration of more functional patterns of activity across the aged brain and reducing the risk of developing a neurological disorder such as stroke or neurodegenerative disease. 展开更多
关键词 aging functional connectivity mitochondria near infrared neural regeneration photobiomodulation red light
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Linking starch particle physicochemical properties to functionality in medicinal plants:Insights from Polygonum multiflorum and Smilax glabra 认领 引用 被引量：1
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作者 Nan Wang Lingling Wu +2 位作者 Yaya Su Haifeng Tang Hailong Yuan 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期487-491,共5页
This study investigates the properties of high-purity starches extracted from Polygonum multiflorum(PMS)and Smilax glabra(SGS).The starches were characterized by scanning electron microscopy,Fouriertransform infrared ... This study investigates the properties of high-purity starches extracted from Polygonum multiflorum(PMS)and Smilax glabra(SGS).The starches were characterized by scanning electron microscopy,Fouriertransform infrared spectroscopy,X-ray diffraction,high-performance anion-exchange chromatography,and differential scanning calorimetry.Significant differences were observed in their morphological,physicochemical,and functional properties.PMS had a smaller particle size(13.68 μm),irregular polygonal shape,A-type,lower water absorption(62.67 %),and higher oil absorption(51.17 %).In contrast,SGS exhibited larger particles(31.75 μm),a nearly spherical shape,B-type,higher crystallinity(50.66 %),and greater amylose content(21.54 %),with superior thermal stability,shear resistance,and gelatinization enthalpy.SGS also contained higher resistant starch(83.28 %) and longer average chain length(20.58 %),but showed lower solubility,swelling power,light transmittance,and freeze-thaw stability.The physicochemical properties differences in crystal pattern and particle morphology between PMS and SGS lead to distinct behaviors during in vitro digestion and fermentation.These findings highlight the potential of medicinal plant starches in functional ingredients and industrial processes. 展开更多
关键词 Starch particle Physicochemical properties Starch function Resistant starch Starch extraction
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The enhanced Cu/MXene heterointerfaces coupled with silver facilitate the integration of high conductivity functionality and strong mechanical properties 认领 引用
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作者 Peng Chen Yilong Liang +4 位作者 Guigui Peng Guanyu He Xianli Ren Xianyun Feng Xing Ran 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第33期163-175,共13页
Interface issues have consistently impeded efforts to balance a trade-off between the conductivity functionality and mechanical properties of Cu-matrix composites.Combining first-principles simulations,this study addr... Interface issues have consistently impeded efforts to balance a trade-off between the conductivity functionality and mechanical properties of Cu-matrix composites.Combining first-principles simulations,this study addresses this challenge by preparing a new Cumatrix composite reinforced with MXene,Cu/Ag@MXene composite block(CuAM-CB),which improves the compatibility between metallic Cu and nonmetallic MXene facilitated by Ag modification anchored in situ onto MXene nanosheets,thus realizing element-coupled reinforcement of Ag at the Cu/MXene heterointerfaces.Benefiting from the strong interaction between Ag and C atoms from in situ self-reduction,as well as the excellent compatibility between Ag and Cu atoms(both IB group metals),Ag atoms act as a mediator for the electron transport and mechanical connection at the Cu/MXene heterointerfaces,enabling CuAM-CB to achieve integrated high conductivity functionality(up to 95%IACS)and strong mechanical properties(with a strength-plasticity product of∼18 GPa%). 展开更多
关键词 Cu-matrix composites MXene Element-coupled heterointerfaces High conductivity functionality Strong mechanical properties
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Assembly processes of rare and abundant microbial taxa are closely related to bacterial and fungal functionality during desert vegetation reestablishment 认领 引用
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作者 Zhouchang YU Wei ZHANG +11 位作者 Pian DUO Ying ZHANG Xingfang TIAN Lin SUN Yuzheng GU Junhong ZHANG Jiaxing SONG Ahejiang SAILIKE Yujie LIANG Rong FU Zhiguo XIE Peizhi YANG 《Pedosphere》 SCIE CAS CSCD 2025年第3期475-489,共15页
Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of ... Effective vegetation reconstruction plays a vital role in the restoration of desert ecosystems.However,in reconstruction of different vegetation types,the community characteristics,assembly processes,and functions of different soil microbial taxa under environmental changes are still disputed,which limits the understanding of the sustainability of desert restoration.Hence,we investigated the soil microbial community characteristics and functional attributes of grassland desert(GD),desert steppe(DS),typical steppe(TS),and artificial forest(AF)in the Mu Us Desert,China.Our findings confirmed the geographical conservation of soil microbial composition but highlighted decreased microbial diversity in TS.Meanwhile,the abundance of rare taxa and microbial community stability in TS improved.Heterogeneous and homogeneous selection determined the assembly of rare and abundant bacterial taxa,respectively,with both being significantly influenced by soil moisture.In contrast,fungal communities displayed stochastic processes and exhibited sensitivity to soil nutrient conditions.Furthermore,our investigation revealed a noteworthy augmentation in bacterial metabolic functionality in TS,aligning with improved vegetation restoration and the assemblage of abundant bacterial taxa.However,within nutrient-limited soils(GD,DS,and AF),the assembly dynamics of rare fungal taxa assumed a prominent role in augmenting their metabolic capacity and adaptability to desert ecosystems.These results highlighted the variations in the assembly processes and metabolic functions of soil microorganisms during vegetation reestablishment and provided corresponding theoretical support for anthropogenic revegetation of desert ecosystems. 展开更多
关键词 deterministic processes metabolic function microbial community assembly rare microbial taxa revegetation stochastic processes
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Construction of a Virtual Twin Testing Framework for Safety of the Intended Functionality in Intelligent Connected Vehicles 认领 引用 被引量：1
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作者 Quanyou Fu Daxu Sun 《Journal of Electronic Research and Application》 2025年第5期12-17,共6页
This study aims to construct a virtual twin testing framework for the safety of the intended functionality of intelligent connected vehicles to address the safety requirements of intelligent driving and transportation... This study aims to construct a virtual twin testing framework for the safety of the intended functionality of intelligent connected vehicles to address the safety requirements of intelligent driving and transportation systems.The research methods include the construction of a theoretical model of safety for intelligent connected vehicles based on the concept of virtual twins,the correlation study between key concepts and functional safety,and the application research of virtual twin technology in the safety testing of intelligent connected vehicles.The results reveal that the virtual twin testing framework can effectively enhance the functional safety of intelligent connected vehicles,reduce development costs,and shorten the product launch cycle.The conclusion suggests that this framework provides strong support for the healthy development of the intelligent connected vehicle industry and has a positive impact on the safety and efficiency of intelligent transportation systems. 展开更多
关键词 Intelligent connected vehicles Safety of the intended functionality Virtual twin Testing framework Safety theory model
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Advances in artificial blood vessels:Exploring materials,preparation,and functionality 认领 引用 被引量：5
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作者 Feng Wang Mengdi Liang +5 位作者 Bei Zhang Weiqiang Li Xianchen Huang Xicheng Zhang Kaili Chen Gang Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第16期225-256,共32页
Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery... Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research. 展开更多
关键词 Artificial blood vessels Materials choice Preparation techniques Performance requirements Functionalization
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A review on cell damage,viability,and functionality during 3D bioprinting 认领 引用 被引量：10
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作者 He-Qi Xu Jia-Chen Liu +1 位作者 Zheng-Yi Zhang Chang-Xue Xu 《Military Medical Research》 SCIE CAS CSCD 2023年第5期620-635,共16页
Three-dimensional(3D)bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials and living cells.Even though 3D bioprinting techniques have experienced... Three-dimensional(3D)bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials and living cells.Even though 3D bioprinting techniques have experienced significant advancement over the past decades,it remains challenging for 3D bioprinting to artificially fabricate functional tissues/organs with high post-printing cell viability and functionality since cells endure various types of stress during the bioprinting process.Generally,cell viability which is affected by several factors including the stress and the environmental factors,such as pH and temperature,is mainly determined by the magnitude and duration of the stress imposed on the cells with poorer cell viability under a higher stress and a longer duration condition.The maintenance of high cell viability especially for those vulnerable cells,such as stem cells which are more sensitive to multiple stresses,is a key initial step to ensure the functionality of the artificial tissues/organs.In addition,maintaining the pluripotency of the cells such as proliferation and differentiation abilities is also essential for the 3D-bioprinted tissues/organs to be similar to native tissues/organs.This review discusses various pathways triggering cell damage and the major factors affecting cell viability during different bioprinting processes,summarizes the studies on cell viabilities and functionalities in different bioprinting processes,and presents several potential approaches to protect cells from injuries to ensure high cell viability and functionality. 展开更多
关键词 Three-dimensional bioprinting Cell damage Shear stress Cell viability Cell functionality
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A Survey on an Emerging Safety Challenge for Autonomous Vehicles:Safety of the Intended Functionality 认领 引用 被引量：6
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作者 Hong Wang Wenbo Shao +3 位作者 Chen Sun Kai Yang Dongpu Cao Jun Li 《Engineering》 SCIE EI CAS CSCD 2024年第2期17-34,共18页
As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(S... As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(SOTIF)has emerged,presenting significant challenges to the widespread deployment of AVs.SOTIF focuses on issues arising from the functional insufficiencies of the AVs’intended functionality or its implementation,apart from conventional safety considerations.From the systems engineering standpoint,this study offers a comprehensive exploration of the SOTIF landscape by reviewing academic research,practical activities,challenges,and perspectives across the development,verification,validation,and operation phases.Academic research encompasses system-level SOTIF studies and algorithm-related SOTIF issues and solutions.Moreover,it encapsulates practical SOTIF activities undertaken by corporations,government entities,and academic institutions spanning international and Chinese contexts,focusing on the overarching methodologies and practices in different phases.Finally,the paper presents future challenges and outlook pertaining to the development,verification,validation,and operation phases,motivating stakeholders to address the remaining obstacles and challenges. 展开更多
关键词 Safety of the intended functionality Autonomous vehicles Artificial intelligence Uncertainty Verification Validation
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Effect and cerebral mechanism of moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation and myofascial pain syndrome by resting-state functionality magnetic resonance imaging:protocol for an observational study 认领 引用 被引量：17
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作者 YANG Jun XIONG Jun +2 位作者 XU Shaozhong XIE Hongwu XIANG Jie 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第1期175-180,共6页
We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational st... We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion. 展开更多
关键词 lumbar disc herniation myofascial pain syndrome point GV3(Yaoyangguan) resting-state functionality magnetic resonance imaging heat-sensitive moxibustion mean fractional amplitude of low-frequency fluctuation regional homogeneity pilot projects
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Flow cytometry for the assessment of animal sperm ntegrity and functionality: state of the art 认领 引用 被引量：3
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作者 Md. Sharoare Hossain Anders Johannisson +3 位作者 Margareta Wallgren Szabolcs Nagy Amanda Pimenta Siqueira Heriberto Rodriguez-Martinez 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第3期406-419,511,共14页
Flow cytometry is now a recognized methodology within animal spermatology, and has moved from being a research tool to become routine in the assessment of animal semen destined to breeding. The availability of ＇bench... Flow cytometry is now a recognized methodology within animal spermatology, and has moved from being a research tool to become routine in the assessment of animal semen destined to breeding. The availability of ＇bench-top＇ flow cytometers and of newer and versatile markers for cell structure and function had allowed the instrumentation to measure more sperm parameters, from viability to reactiveness when exposed to exogenous stimuli, and to increase our capabilities to sort spermatozoa for potential fertilizing capacity, or chromosomal sex. The present review summarizes the state of the art regarding flow cytometry applied to animal andrology, albeit keeping an open comparative intent. It critically evaluates the present and future capabilities of flow cytometry for the diagnostics of potential fertility and for the development of current reproductive technologies such as sperm freezing, sperm selection and sperm sorting. The flow cytometry methods will probably further revolutionize our understanding of the sperm physiology and their functionality, and will undoubtedly extend its application in isolating many uncharacterized features of spermatozoa. However, continuous follow-up of the methods is a necessity owing to technical developments and the complexity of mapping spermatozoa. 展开更多
关键词 animals fertility flow cytometry semen analysis spermatozoa sperm functionality sperm intactness
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Evaluating alternative hypotheses behind biodiversity and multifunctionality relationships in the forests of Northeastern China 认领 引用 被引量：5
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作者 Qingmin Yue Minhui Hao +5 位作者 Yan Geng Xuerui Wang Klaus von Gadow Chunyu Zhang Xiuhai Zhao Lushuang Gao 《Forest Ecosystems》 SCIE CSCD 2022年第3期301-310,共10页
Background:The importance of biodiversity in maintaining multiple ecosystem functions has been widely accepted.However,the specific mechanisms affecting biodiversity and ecosystem multifunctionality(BEMF)relationships... Background:The importance of biodiversity in maintaining multiple ecosystem functions has been widely accepted.However,the specific mechanisms affecting biodiversity and ecosystem multifunctionality(BEMF)relationships in forests are largely unknown.This is particularly evident for the macroscale of a large forested landscape.Methods:Based on 412 one-tenth hectare field plots distributed over forested areas across northeastern China,we evaluated three alternative hypotheses explaining the relationships between BEMF,namely:niche complementarity,mass ratio,and vegetation quantity effect.We used Rao's quadratic entropy and community weighted mean trait values to quantify forest“biodiversity”.These two variables represent two complementary aspects of functional properties,which are in line with niche complementary and mass ratio effects,respectively.Results:Ecosystem multifunctionality was negatively associated with the community weighted mean values of acquisitive traits(a proxy of mass ratio effect).Rao's quadratic entropy(a proxy of niche complementarity)had no relationship with ecosystem multifunctionality.Higher stand biomass greatly increased ecosystem multifunctionality,which is in line with the vegetation quantity effect.Our results confirm that in the temperate forests of northeastern China,the relationship of BEMF was primarily affected by vegetation quantity,followed by mass ratio effects.Conclusions:The results of this study contribute to a better understanding of the main drivers of ecosystem multifunctionality in forest ecosystems.The results of this study provide additional evidence to support the vegetation quantity and mass ratio hypotheses in forest ecosystems. 展开更多
关键词 Biodiversity and ecosystem multifunctionality Biomass Functional traits Mass ratio effect Niche complementarity effect Vegetation quantity effect
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Shaking table test study on performance and functionality of a typical telecommunication room after earthquakes 认领 引用 被引量：1
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作者 Li Bo Guo Endong +5 位作者 Sun Guoliang Ji Shuqiang Mao Chenxi Wang Tao Han Di Li Xiaofei 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第2期455-474,共20页
Large numbers of basic transceiver stations,where the telecommunication room is one of the main components,comprise an important part of the telecommunication system.After earthquakes,considerable economic loss from t... Large numbers of basic transceiver stations,where the telecommunication room is one of the main components,comprise an important part of the telecommunication system.After earthquakes,considerable economic loss from telecommunication systems is often associated with seismic damage and functional loss of the telecommunication room.However,research related to this has been limited.In this study,shaking table tests were conducted for a full-scale typical telecommunication room,including a light-steel house and the necessary communication and power supply equipment.The tests not only focused on the seismic damage to all the structures but also considered the functions of the communication and power supply of the equipment.The interactions between these facilities and their effects on communication function were also investigated.Compared with the damage to structures,the interruption of the power supply due to earthquakes is a weak link.Finally,the damage indexes,together with their threshold values of different damage states for the communication and power supply equipment,were derived from the test results.The results of this research can contribute to the literature gaps regarding seismic performance studies of telecommunication rooms,and can serve as a valuable reference for future research on its seismic fragility and economic losses evaluation. 展开更多
关键词 telecommunication light-steel house communication equipment power supply equipment seismic performance functionality
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Functionality proportion and corresponding stability study of multivariate metal-organic frameworks 认领 引用 被引量：1
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作者 Jie Li Yecheng Wang +1 位作者 Yan Yu Qiaowei Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第6期837-841,共5页
Multivariate metal-organic frameworks（MTV-MOFs） with different ratios of terephthalate（BDC） linker and amino-benzenedicarboxylate（BDC-NH2） linker were synthesized through both direct synthesis from linker mixtur... Multivariate metal-organic frameworks（MTV-MOFs） with different ratios of terephthalate（BDC） linker and amino-benzenedicarboxylate（BDC-NH2） linker were synthesized through both direct synthesis from linker mixture and linker exchange of activated single-linker MOFs. Functionality proportion was impacted by the thermodynamics during the one-pot MOF construction, resulting in preference of BDC over BDC-NH2 in the MTV-MOF, in agreement with the quantum mechanics calculations. The functionality difference also affects the thermodynamics in the linker exchange process, as indicated by the more effective linker exchange in BDC-NH2-based IRMOF-3 than in BDC-based MOF-5. Furthermore,the thermal decomposition temperatures and chemical integrity upon ambient air exposure of these MOFs with variate functionalities were investigated, and it reveals that higher proportion of BDC in the MTV-MOF crystals contribute to both higher thermal and higher chemical stabilities. 展开更多
关键词 Multivariate metal-organic frameworks Direct synthesis Linker exchange Functionality proportion
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Functionality evaluation of system of systems architecture based on extended influence diagrams 认领 引用 被引量：1
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作者 ZHANG Mengmeng CHEN Honghui +2 位作者 ZHANG Xiaoxue LUO Aimin LIU Junxian 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2018年第3期510-518,共9页
System of systems architecture（SoSA） has received increasing emphasis by scholars since Zachman ignited its flame in 1987. Given its complexity and abstractness, it is critical to validate and evaluate SoSA to ensur... System of systems architecture（SoSA） has received increasing emphasis by scholars since Zachman ignited its flame in 1987. Given its complexity and abstractness, it is critical to validate and evaluate SoSA to ensure requirements have been met.Multiple qualities are discussed in the literature of SoSA evaluation, while research on functionality is scarce. In order to assess SoSA functionality, an extended influence diagram（EID） is developed in this paper. Meanwhile, a simulation method is proposed to elicit the conditional probabilities in EID through designing and executing SoSA. An illustrative anti-missile architecture case is introduced for EID development, architecture design, and simulation. 展开更多
关键词 system of systems architecture（SoSA） functionality evaluation extended influence diagram（EID） anti-missile architecture simulation
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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets 认领 引用
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作者 Dirkjan Schokker Soumya K.Kar +3 位作者 Els Willems Alex Bossers Ruud A.Dekker Alfons J.M.Jansman 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第1期313-328,共16页
Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome an... Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning piglets.In study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were investigated.In study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression profiles.Results Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals inter-changed.In the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal tissue.These genes are involved in biological processes related to immunity and inflammatory responses.For example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum tissue.In the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O content compared to low Zn O content.Conclusions Supplementing a diet with a pharmaceutical level of Zn as Zn O for clinically healthy post weaning piglets influences various aspects intestinal functionality,in particular in the first two weeks post-weaning.The model intervention increased both the alpha diversity of the intestinal microbiome and the expression of a limited number of genes linked to the local immune system in intestinal tissue.The effects do not seem related to a direct antimicrobial effect of Zn O. 展开更多
关键词 Immune system Intestinal functionality Microbiota Piglets Zinc oxide
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Elaboration of Materials with Functionality Gradients by Assembly of Chitosan-Collagen Microspheres Produced by Microfluidics 认领 引用
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作者 David Azria Raluca Guermache +4 位作者 Sophie Raisin Sébastien Blanquer Frédéric Gobeaux Marie Morille Emmanuel Belamie 《Journal of Renewable Materials》 SCIE EI CAS 2018年第3期314-324,共11页
Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilici... Biopolymers extracted from renewable resources like chitosan and collagen exhibit interesting properties for the elaboration of materials designed for tissue engineering applications,among which are their hydrophilicity,biocompatibility and biodegradability.In many cases,functional recovery of an injured tissue or organ requires oriented cell outgrowth,which is particularly critical for nerve regeneration.Therefore,there is a growing interest for the elaboration of materials exhibiting functionalization gradients able to guide cells.Here,we explore an original way of elaborating such gradients by assembling particles from a library of functionalized microspheres.We propose a simple process to prepare chitosan-collagen hybrid microspheres by micro-and milli-fluidics,with adaptable dimensions and narrow size distributions.The adhesion and survival rate of PC12 cells on hybrid microspheres were compared to those on pure chitosan ones.Finally,functionalized microspheres were assembled into membranes exhibiting a functionalization gradient. 展开更多
关键词 Hybrid microspheres biomaterials chitosan collagen functionality gradient nerve regeneration microfluidics
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Functionality Semantics of Predicate Data Flow Diagram 认领 引用
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作者 高晓雷 缪淮扣 刘玲 《Journal of Shanghai University(English Edition)》 2004年第3期309-316,共8页
SOZL (structured methodology + object-oriented methodology + Z language) is a language that attempts to integrate structured method, object-oriented method and formal method. The core of this language is predicate dat... SOZL (structured methodology + object-oriented methodology + Z language) is a language that attempts to integrate structured method, object-oriented method and formal method. The core of this language is predicate data flow diagram (PDFD). In order to eliminate the ambiguity of predicate data flow diagrams and their associated textual specifications, a formalization of the syntax and semantics of predicate data flow diagrams is necessary. In this paper we use Z notation to define an abstract syntax and the related structural constraints for the PDFD notation, and provide it with an axiomatic semantics based on the concept of data availability and functionality of predicate operation. Finally, an example is given to establish functionality consistent decomposition on hierarchical PDFD (HPDFD). 展开更多
关键词 predicate data flow diagram (PDFD) predicate operation (PO) hierarchical predicate data flow diagram (HPDFD) availability functionality semantics.
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The Information Efficiency and Functionality Efficiency of Stock Markets 认领 引用
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作者 邹辉文 《Journal of Donghua University(English Edition)》 EI CAS 2011年第4期431-438,共8页
The efficiency of a stock market is principally measured by its information efficiency and functionality efficiency. Both metrics are closdy related to the information of stock markets. However, there is no uniform de... The efficiency of a stock market is principally measured by its information efficiency and functionality efficiency. Both metrics are closdy related to the information of stock markets. However, there is no uniform definition of information in the economy field since researchers may have various opinions on the information of stock markets. In this research, a comparatively strict definition of information in sense of economy is presented. Based on this definition, the optimal conditions to reach the maximum information efficiency and functionality efficiency of stock markets are derived. The conclusion is, only when the market＇s operation and information transmission mechanisms are fully effective, its information completeness degree is optimal, all investors take optimal equilibrium actions, and the information efficiency and functionality efficiency of stock markets will be optimal. Based on the conclusions, the information efficiency and functionality efficiency of reality stock markets in China are studied and the corresponding supervision countermeasures are suggested. 展开更多
关键词 information definition stock market information efficiency functionality efficiency
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Functional diversity dominates positive species mixture effects on ecosystem multifunctionality in subtropical plantations 认领 引用 被引量：11
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作者 Xi Li Hui Wang +4 位作者 Junwei Luan Scott X.Chang Bing Gao Yi Wang Shirong Liu 《Forest Ecosystems》 SCIE CSCD 2022年第3期417-426,共10页
Mixed-species plantations generally exhibit higher ecosystem multifunctionality than monospecific plantations.However,it is unclear how tree species functional composition influences species mixture effects on ecosyst... Mixed-species plantations generally exhibit higher ecosystem multifunctionality than monospecific plantations.However,it is unclear how tree species functional composition influences species mixture effects on ecosystem multifunctionality.We selected 171 monospecific and mixed-species plantations from nine regions across subtropical China,and quantified 13 key ecosystem functional properties to investigate how species mixture effects on ecosystem multifunctionality are modulated by functional diversity and identity.We found that ecosystem multifunctionality was significantly higher(p<0.05)in mixed tree plantations than in monospecific plantations except the mixed-conifer species plantations.Across all regions,ecosystem multifunctionality was significantly higher(p<0.05)in mixed conifer-broadleaf plantations than in monospecific plantations of the corresponding species,but not different between mixed and monospecific coniferous plantations.The magnitude of species mixture effects on ecosystem multifunctionality varied greatly with tree species compositions.Taking Cunninghamia lanceolata Lamb.as an example,the effects varied from a range of 2.0%–9.6%when mixed with a conifer species to 36%–87%when mixed with a broadleaf species.The functional diversity was the dominate driver shaping ecosystem multifunctionality,while functional identity,as expressed by community-weighted mean of specific leaf area,also had a positive effect on ecosystem multifunctionality through the increased below-ground nitrogen and phosphorus stocks regulated by specific leaf area of the mixing tree species.Our study highlights the important role of functional diversity in shaping ecosystem multifunctionality across region-wide environmental conditions.Mixed conifer-broadleaf tree plantations with distinct functional traits benefit the enhancement of ecosystem multifunctionality,and the magnitude of species mixture effects is modulated by the functional identity of tree species composition;those relationships deserve a special consideration in multifunctional management context of subtropical plantations. 展开更多
关键词 Ecosystem multifunctionality Species mixture effects Functional diversity Functional identity Mixed tree plantations Monospecific plantations
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Phosphatidylserine:An overview on functionality,processing techniques,patents,and prospects 认领 引用 被引量：3
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作者 Jingnan Chen Jun Li +4 位作者 Haoyu Xu Jiaxi Li Yonghong Yuan Xuebing Xu Yanlan Bi 《Grain & Oil Science and Technology》 CAS 2023年第4期206-218,共13页
Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited... Phosphatidylserine(PS)is the part of cell structure in the body and has many beneficial functions especially in brain-related aging diseases.Although daily foods can provide PS to human body,the amount is very limited due to its poverty in most foods.To overcome the issue,numerous studies based on PS have been reported to develop PS-related supplements.In this review,PS was comprehensively and critically reviewed from the view of resources,functions,processing techniques,patents,and prospects.For resources,animal,plant,and microorganism origins were all covered with their differences in composition profiles.For functions,benefits regarding memory,cognitive enhancement,exercise performance,reducing Alzheimer’s disease,and attention-deficit hyperactivity disorder symptoms were covered as well as the functional differences among animal-,plant-,and microorganism-based PS-related supplements.For processing techniques,traditional extracting methods from animal,plant,and microorganism tissues were comparatively discussed with enzymatic synthesis based on different reaction systems.Finally,patents of PS-related supplements were evaluated as well as their applications.This review could provide scientific and valuable support for PS industry. 展开更多
关键词 Phosphatidylserine Functionality Processing techniques Patents evaluation Prospects
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