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NLRP3 inflammasome and gut microbiota–brain axis:A new perspective on white matter injury after intracerebral hemorrhage 认领 引用 被引量：3
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作者 Xiaoxi Cai Xinhong Cai +4 位作者 Quanhua Xie Xueqi Xiao Tong Li Tian Zhou Haitao Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期62-80,共19页
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev... Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have revealed that gut microbiota can communicate bidirectionally with the brain through the gut microbiota–brain axis.This axis indicates that gut microbiota is closely related to the development and prognosis of intracerebral hemorrhage and its associated secondary white matter injury.The NACHT,LRR,and pyrin domain-containing protein 3(NLRP3)inflammasome plays a crucial role in this context.This review summarizes the dysbiosis of gut microbiota following intracerebral hemorrhage and explores the mechanisms by which this imbalance may promote the activation of the NLRP3 inflammasome.These mechanisms include metabolic pathways(involving short-chain fatty acids,lipopolysaccharides,lactic acid,bile acids,trimethylamine-N-oxide,and tryptophan),neural pathways(such as the vagus nerve and sympathetic nerve),and immune pathways(involving microglia and T cells).We then discuss the relationship between the activated NLRP3 inflammasome and secondary white matter injury after intracerebral hemorrhage.The activation of the NLRP3 inflammasome can exacerbate secondary white matter injury by disrupting the blood–brain barrier,inducing neuroinflammation,and interfering with nerve regeneration.Finally,we outline potential treatment strategies for intracerebral hemorrhage and its secondary white matter injury.Our review highlights the critical role of the gut microbiota–brain axis and the NLRP3 inflammasome in white matter injury following intracerebral hemorrhage,paving the way for exploring potential therapeutic approaches. 展开更多
关键词 gut microbiota gut microbiota–brain axis immune intracerebral hemorrhage neuroinflammation NLRP3 protein stroke therapeutics white matter injury
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Phellodendron amurense Rupr.Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota 认领 引用 被引量：1
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作者 Mei Mei Huawei Sun +3 位作者 Kai Zhang Feng Zhang Shiqing Sun Yu Zhang 《Natural Products and Bioprospecting》 CSCD 2026年第1期212-229,共18页
In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism o... In this study,a diabetic nephropathy(DN)rat model was established using 2%Streptozocin(STZ)solution,and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mecha-nism of Phellodendron amurense Rupr.Polysaccharides(PAP)in ameliorating DN.Results demonstrated that PAP,a neu-tral homogeneous polysaccharide with molecular weight of 1.98 × 105 Da composed of Rha,GalA,Gal,and D-Xyl,exerted renal protective effects through multiple pathways.It enhanced renal antioxidant capacity and alleviated oxidative damage in DN by upregulating PI3K/AKT pathway-related protein expression.Simultaneously,PAP acti-vated theTGF-β/Smad pathway via Nrf2 to mitigate renal fibrosis symptoms in DN,while inhibiting cellular apoptosis.Furthermore,PAP suppressed renal inflammation through gut microbiota reduction,thereby protecting against renal injury in DN rats.This study reveals that PAP alleviates DN symptoms by modulating gut microbiota,enhancing anti-oxidant and anti-fibrotic capacities,and inhibiting apoptotic pathways,comprehensively elucidating its multifaceted therapeutic mechanisms against DN. 展开更多
关键词 Phellodendron amurense Rupr.Polysaccharides Diabetic nephropathy Gut microbiota
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High-altitude exposure remodels the gut microbiota:health and disease 认领 引用
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作者 Yan Li Mingshan Jiang +7 位作者 Jiangmei Pang Chunxiang Ma Hong Zhang Fang Yin Yongbin Jia Xiang Zou Tao Zuo Hu Zhang 《MedScience》 SCIE CAS CSCD 2026年第1期120-146,共27页
With the increasing number of individuals travelling to or residing in high-altitude regions,understanding the physiological and pathological consequences of such environments has become increasingly important.High-al... With the increasing number of individuals travelling to or residing in high-altitude regions,understanding the physiological and pathological consequences of such environments has become increasingly important.High-altitude exposure poses significant challenges to human health,primarily due to hypobaric hypoxia,which triggers a cascade of responses,including energy deficiency,oxidative stress,and inflammation.One of the critical consequences is the disruption of the gut barrier,which facilitates the translocation of the gut microbiota and further exacerbates local and systemic inflammation.Notably,the gut microbiota,a dynamic environmental sensor,undergoes significant remodelling in high-altitude environments.The modified production of microbial metabolites such as bile acids influences gut homeostasis as well as glucose and lipid metabolism,and ultimately contributes to individual variability in high-altitude acclimatization.These changes have been implicated in the pathogenesis of altitude-related illnesses such as acute and chronic mountain sickness,as well as in metabolic and gastrointestinal disorders such as diabetes,obesity,irritable bowel syndrome,colorectal cancer,cholelithiasis,and osteoporosis.Preliminary explorations have demonstrated the therapeutic potential of microbiome-based interventions such as faecal microbiota transplantation in acute and chronic mountain sickness.Further research into gut microbiota modulation may provide applicable options for promoting highaltitude acclimatization and preventing high-altitude illness. 展开更多
关键词 gut microbiota hypoxia gut barrier acclimatization mountain sickness
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Positive impact of indicaxanthin from Opuntia ficusindica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis 认领 引用
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作者 Simona Terzo Antonella Amato +12 位作者 Pasquale Calvi Marta Giardina Domenico Nuzzo Pasquale Picone Antonio Palumbo-Piccionello Sara Amata Ilenia Concetta Giardina Alessandro Massaro Ignazio Restivo Alessandro Attanzio Luisa Tesoriere Mario Allegra Flavia Mulè 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期324-332,共9页
Indicaxanthin is a betalain that is abundant in Opuntia ficus-indica orange fruit and has antioxidative and anti-inflammatory effects. Nevertheless, very little is known about the neuroprotective potential of indicaxa... Indicaxanthin is a betalain that is abundant in Opuntia ficus-indica orange fruit and has antioxidative and anti-inflammatory effects. Nevertheless, very little is known about the neuroprotective potential of indicaxanthin. This study investigated the impact of indicaxanthin on neuronal damage and gut microbiota dysbiosis induced by a high-fat diet in mice. The mice were divided into three groups according to different diets: the negative control group was fed a standard diet;the high-fat diet group was fed a high-fat diet;and the high-fat diet + indicaxanthin group was fed a high-fat diet and received indicaxanthin orally(0.86 mg/kg per day) for 4 weeks. Brain apoptosis, redox status, inflammation, and the gut microbiota composition were compared among the different animal groups. The results demonstrated that indicaxanthin treatment reduced neuronal apoptosis by downregulating the expression of proapoptotic genes and increasing the expression of antiapoptotic genes. Indicaxanthin also markedly decreased the expression of neuroinflammatory proteins and genes and inhibited high-fat diet–induced neuronal oxidative stress by reducing reactive oxygen and nitrogen species, malondialdehyde, and nitric oxide levels. In addition, indicaxanthin treatment improved the microflora composition by increasing the abundance of healthy bacterial genera, known as producers of short-chain fatty acids(Lachnospiraceae, Alloprovetella, and Lactobacillus), and by reducing bacteria related to unhealthy profiles(Blautia, Faecalibaculum, Romboutsia and Bilophila). In conclusion, indicaxanthin has a positive effect on high-fat diet–induced neuronal damage and on the gut microbiota composition in obese mice. 展开更多
关键词 gut microbiota dysbiosis high-fat diet indicaxanthin microflora neuronal apoptosis neurodegeneration neuroinflammation obesity Opuntia ficus-indica fruit
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Electroacupuncture Ameliorates NLRP3-mediated Pyroptosis in Spinal Cord Injury Rats by Reshaping The Gut Microbiota 认领 引用
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作者 CUI Yin-Jie LI Hong-Ru +6 位作者 LIU Jing-Yi DU Hai-Lin LIU Shu-Wen YANG Yuan ZHENG Chen-Guang XIANG Jian-Qin SONG Xiao-Juan 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2026年第5期1132-1153,共22页
Objective Spinal cord injury(SCI)directly impairs the regulatory function of the autonomic nervous system,induces intestinal dysfunction,and significantly reduces patients’quality of life.Preclinical studies have sho... Objective Spinal cord injury(SCI)directly impairs the regulatory function of the autonomic nervous system,induces intestinal dysfunction,and significantly reduces patients’quality of life.Preclinical studies have shown that electroacupuncture(EA)therapy can regulate the brain-gut axis and is used to treat central nervous system diseases such as major depressive disorder,Alzheimer’s disease and Parkinson’s disease.Recent research has established that fecal microbiota transplantation(FMT)from EAtreated SCI rats restored intestinal motility and colonic morphology.However,it remains unclear whether the regulation of gut microbiota by EA therapy directly contributes to neural repair after SCI.This study aims to explore whether gut microbiota mediates the neuroprotective effect of EA in the treatment of SCI and its possible mechanism.Methods The study employed RNA transcriptome analysis of spinal cord tissue to characterize gene expression profiles and to identify key signaling pathways following EA treatment for SCI.Hematoxylin-Eosin(HE)staining and Nissl staining were used to observe the morphological changes in spinal cord tissue.Western blot(WB)and enzyme-linked immunosorbent assay(ELISA)were applied to detect the effects of EA on the expression of proteins related to nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3)-dependent pyroptosis.Using 16S rDNA sequencing,the study observed alterations in gut microbiota diversity and community composition in SCI rats.Prior to establishing SCI models,rats were pretreated with an antibiotic cocktail to induce gut dysbiosis,and the effects on intestinal function and spinal cord neural repair were evaluated.FMT was performed to investigate the regulatory effects of post-EA FMT on motor function,general status,liver and spleen indices,and NLRP3-mediated pyroptosis in SCI rats.Results EA improved motor function and reduced regulated neuronal cell death in SCI rats.Transcriptomic analysis demonstrated the activation of immune-and inflammation-related pathways post-SCI,including NOD-like receptors,nuclear factor-kappa B(NF-κB),and Toll-like receptor(TLR)pathways.EA primarily influenced intestinal inflammation and autoimmune functions.16S rDNA sequencing illustrated that EA did not alter the diversity of gut microbiota.However,EA altered the gut microbiota composition in SCI rats,increasing Lactobacillus and Akkermansia genera while rebalancing the Firmicutes/Bacteroidetes ratio.Furthermore,depletion of gut microbiota by antibiotics disrupted the intestinal barrier,reduced the expression of intestinal barrier proteins Zonula Occludens-1(ZO-1)and Occludin,elevated serum lipopolysaccharide-binding protein(LBP)levels,exacerbated spinal cord tissue damage,and hindered motor function recovery in SCI rats.FMT from donors treated with EA reduced LBP levels in the intestine,blood,and spinal cord of rats,inhibited the TLR4 myeloid differentiation primary response protein 88(MyD88)-NF‑κB pathway and NLRP3-dependent pyroptosis,and improved motor function.On the other hand,FMT treatment resulted in decreased body weight and food intake,whereas FMT using EA-treated donors effectively alleviated these alterations.Conclusion EA effectively alleviated neuroinflammatory responses in rats with SCI,primarily through regulating the gut microbiota and suppressing the NLRP3-dependent pyroptosis signaling pathway. 展开更多
关键词 electroacupuncture spinal cord injury fecal microbiota transplantation gut microbiota pyroptosis NLRP3 inflammasome
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Effects of aging on gut microbiota nearly throughout zebrafish lifespan 认领 引用
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作者 Fanshu Xiao Wengen Zhu +4 位作者 Huanping Liu Pubo Chen Yuhe Yu Zhili He Qingyun Yan 《Current Zoology》 SCIE CAS CSCD 2026年第2期303-306,共4页
Aging profoundly influences vertebrate gut microbiota,yet lifespan patterns remain poorly characterized.Utilizing the wild-type zebrafish model,this study pioneers a longitudinal investigation of gut microbiota dynami... Aging profoundly influences vertebrate gut microbiota,yet lifespan patterns remain poorly characterized.Utilizing the wild-type zebrafish model,this study pioneers a longitudinal investigation of gut microbiota dynamics from adulthood(>3 months)to old age(>3 years).We identified a significant(P<0.05)correlation between gut microbiota composition and host age.Notably,alpha-diversity was relatively stable and highest between 8–32 months,indicating this period as optimal for gut microbiota studies.The relative abundance of dominant phyla(Pseudomonadota,Actinomycetota,and Fusobacteriota)varied significantly(P<0.05)across aging stages.Crucially,these phylum-level changes were predictable using their representative genera or amplicon sequence variants.This work delineates lifelong aging effects on gut microbiota in a vertebrate model and identifies key microbial biomarkers and an optimal sampling window. 展开更多
关键词 aging effects gut microbiota lifespan patterns vertebrate model zebrafish
Study of the biological fermentation modification of okara dietary fiber on the regulation on gut microbiota and lipid metabolism in hyperlipidemic mice 认领 引用
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作者 Yaqiong Wan Zhengyang Cheng +7 位作者 Nourhan Nassar Jieping Zhang Meifang Hu Xiaohan Zhou Dongqi Li Yibin Zhou Yayuan Xu Jianghua Cheng 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期395-411,共17页
Okara is produced in large quantities annually in China,but much of it is discarded due to its high content of indigestible dietary fiber(DF),contributing to significant environmental challenges.Recognizing the undere... Okara is produced in large quantities annually in China,but much of it is discarded due to its high content of indigestible dietary fiber(DF),contributing to significant environmental challenges.Recognizing the underexplored medicinal potential of DF,we developed an efficient fermentation method to enhance the bioavailability of okara fiber.In this study,Pediococcus acidilactici IFJ-1,which has strong enzymatic production capabilities and beneficial effects on gastrointestinal flora modulation,was selected to ferment okara.Results showed decreases in viscosity and particle size,optimized surface structure,improved thermal stability and hydration properties,and a significant increase in soluble DF content from 1.85%to 3.91%.To evaluate the physiological effects,hyperlipidemic mouse models were established and subjected to dietary interventions utilizing okara and fermented okara to measure changes in physicochemical parameters,gut microbiota composition,and lipid metabolism.The dietary intervention was effective,particularly in the fermented okara group,showing a 7.3%weight loss,improved blood lipids(triglycerides:‒39.8%,total cholesterol:‒12.8%,low-density lipoprotein cholesterol:‒34.2%,high-density lipoprotein cholesterol:+26.2%),and a 22.2%lower liver index.Gut microbiota analysis revealed that fermented okara positively modulated the microbial community by increasing the abundance of beneficial bacteria(e.g.,Bacteroidota)and reducing the abundance of obesity-associated bacteria(e.g.,Bacillota).Lipid metabolism profiling further demonstrated that fermented okara downregulated harmful lipids(e.g.,(O-acyl)-ω-hydroxy fatty acids,ceramides,and diacylglycerols)while upregulating beneficial phospholipids(e.g.,phosphatidylinositol,phosphatidylserine,phosphatidylethanolamine,lysophosphatidylinositol and lysophosphatidic acid).This study highlights a novel approach for enhancing DF utilization through fermentation,providing valuable insights into strategies for preventing obesity and metabolic diseases. 展开更多
关键词 Okara Dietary fiber Fermentation Pediococcus acidilactici IFJ-1 Gut microbiota Lipid metabolism
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Probiotics is riding high:effects of gut microbiota on skin health 认领 引用
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作者 Zheyi Song Renyi Song +2 位作者 Lan Lan Kejun Cheng Xin Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期1965-1975,共11页
The human skin is one of the largest epithelial surfaces that can resist external damage and protect against the external environment.The intricate connection between the skin and the gut has been shown by recent rese... The human skin is one of the largest epithelial surfaces that can resist external damage and protect against the external environment.The intricate connection between the skin and the gut has been shown by recent research.The homeostasis of gut microbiota impacts skin conditions,while the dysbiosis of microbiota may destroy mucosal immune tolerance and exacerbate skin inflammation.Moreover,the term gut-brain-skin axis has gradually attracted much interest from researchers.Emotional states including stress,depression,and anxiety will change the gut microbiota,trigger the inflammatory response,and negatively impact skin health.Numerous skin issues have been found to be improved by probiotics,including oxidative stress reduction,immune response regulation,and enhanced skin barrier function This paper attempts to show the significance of gut microbiota on skin disorders and the connection signaling of the gut-brain-skin axis.Additionally,by summarizing the mechanism of probiotic usage in improving skin health,we also provide a mathematical foundation for the use of probiotics in skin health. 展开更多
关键词 Skin Skin diseases Gut microbiota Probiotics Gut-skin axis Gut-brain-skin axis
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Grape peel phenolics on improving obesity by modulating gut microbiota and its related metabolism 认领 引用
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作者 Wenyu Cui Ben Xu +5 位作者 Fuchun Chen Hang Li Weijun Shen Changwei Liu Fachun Wan Anwei Cheng 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1084-1099,共16页
Grape peel,as the by-product of grape wine,is rich in phenolic and proanthocyanidins.Obesity has become a serious global public health problem and supplementation of grape peel phenolics(GPP)may be an effective interv... Grape peel,as the by-product of grape wine,is rich in phenolic and proanthocyanidins.Obesity has become a serious global public health problem and supplementation of grape peel phenolics(GPP)may be an effective intervention method.From a dietary nutrition perspective,this study aims to investigate the effects of GPP on improving intestinal barrier function in high-fat diet-treated mice,and further explore the potential mechanism.The results showed that GPP supplementation obviously reduced body weight of mice,increased the abundance of beneficial bacteria(Akkermansia,g_Lachnospiraceae_NK4A136_group,Bacteroidetes and g_norank_f_Muribaculaceae),reduced the relative abundance of harmful bacteria(g_Coriobacteriaceae_UCG-002,g_Dubosiella and Romboutsia).Meanwhile,GPP could alleviate colonic barrier inflammation,facilitate the production of short-chain fatty acids and secondary bile acids,increase the mRNA and protein expression levels of intestinal tight junction proteins,and protect intestinal barrier integrity,especially in the LGPP group(100 mg/kg·day GPP).Kyoto Encyclopedia of Genes and Genomes analysis on fecal metabolism indicated that GPP could effectively alleviate intestinal imbalance caused by obesity through targeting multiple shared pathways.Bile secretion and arachidonic acid are the key differential metabolic pathways,and 14 key differential metabolites were identified.In conclusion,GPP supplementation has the potential to alleviate obesity by regulating gut microbiota,improving gut barrier integrity,and modulating the related metabolites. 展开更多
关键词 Grape peel phenolic Obesity Bile acids Gut microbiota Metabolites
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Synergistic interactions between gut microbiota and its associated microbial metabolites in Hermetia illucens mediate the reduction of hexavalent chromium 认领 引用
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作者 Qingcheng Cao Yun Li +4 位作者 Cuncheng Liu Li Chen Yuanhang Qin Tielin Wang Cunwen Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期153-163,共11页
Microbial remediation of hexavalent chromium(Cr(Ⅵ)) contaminants is believed to be effective, and Hermetia illucens can realize the bioremediation of contaminants through biotransformation. However, the synergistic e... Microbial remediation of hexavalent chromium(Cr(Ⅵ)) contaminants is believed to be effective, and Hermetia illucens can realize the bioremediation of contaminants through biotransformation. However, the synergistic effects of larval gut microbiota and its associated microbial metabolites mediate the resistance and reduction of Cr(Ⅵ) remain largely unrecognized. To obtain further details, the feasibility of Cr(Ⅵ) reduction through larval biotransformation was investigated, and the interaction between the role of gut bacteria and the function of their metabolites was clarified. The larvae demonstrated tolerance to the Cr(Ⅵ) stress, and finally achieved Cr(Ⅵ) reduction to Cr(Ⅲ) by biotransformation, resulting in a relative content of Cr(Ⅵ) to the total chromium element in the residual substrate reduced to 1.11%. Myroides, Ulvibacter, Paenalcaligenes, Dysgonomonas, Campylobacter, and Rsa Hf231 in larval gut responded strongly to Cr(Ⅵ) stress. Meanwhile, the highest level of Cr(Ⅵ) stress caused differences in gut microbial metabolism with 124 metabolites being screened as upregulated and 150 metabolites as downregulated compared to that without Cr(Ⅵ) stress. Especially, Dysgonomonas, Enterococcus, Myroides, Paenalcaligenes and Ulvibacter were mainly associated with some metabolites that can be used as electron donors or electronic mediators to assist microbial growth and reduce or detoxify Cr(Ⅵ). These findings indicate that larval biotransformation is a green application for remediating Cr(Ⅵ), and gut microbiota and its associated metabolites can be further mined for Cr(Ⅵ) reduction and detoxification. 展开更多
关键词 Hermetia illucens Gut microbiota Metabolome Biotransformation Cr(VI)reduction
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Electroacupuncture Alleviates Pulmonary and Intestinal Injury in Septic Mice via Inhibiting NLRP3 Inflammasome and Remodeling Gut Microbiota 认领 引用
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作者 Xiao-lei Zhang Hai-ming Hu +5 位作者 Qun-feng Yao Xiong-jie Sun Xiao-wei Yao Lu Cao Jun Ma Hong-tao Liu 《Current Medical Science》 SCIE CAS CSCD 2026年第1期143-160,共18页
Objective Electroacupuncture(EA)has emerged as a clinically adopted complementary modality in the management of res-piratory and digestive disorders.This investigation sought to elucidate the therapeutic potential of ... Objective Electroacupuncture(EA)has emerged as a clinically adopted complementary modality in the management of res-piratory and digestive disorders.This investigation sought to elucidate the therapeutic potential of EA against sepsis-induced pulmonary and gastrointestinal injuries,with particular emphasis on delineating its multimodal mechanistical pathways.Methods Sepsis was induced in C57BL/6 mice by administeringting lipopolysaccharide(LPS)one hour after EA interven-tion at the Zusanli(ST36)and Tianshu(ST25)acupoints for eight days.Inflammatory responses and barrier function were evaluated in the lung and colon tissues.Hematoxylin and Eosin(H&E)staining was performed on lung tissues,while colon tissues were subjected to H&E staining,Wheat Germ Agglutinin-Fluorescein Isothiocyanate(WGA-FITC)staining,and Alcian Blue staining.Additionally,Quantitative Real-Time Polymerase Chain Reaction(qRT-PCR)and Western blotting were used to explore potential molecular mechanisms.Furthermore,16S rRNA gene sequencing was employed to analyze changes in the gut microbiota.Results EA ameliorated both pulmonary injury and intestinal damage in septic mice.This protective effect was mediated through significant attenuation of pulmonary and intestinal inflammation,coupled with partial restoration of gut microbiota homeostasis.Specifically,EA inhibited the activation of Nod-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome and mitogen-activated protein kinase(MAPK)pathways,and upregulated the transcription of lung barrier-related factors(MMP2,MMP9,Occludin)in the lung.In addition,EA improved inflammation and reduced damage to the intestinal mucosal barrier in the colon.This was accomplished by decreasing the expression of pro-inflammatory cytokines(IL-1β,TNF-α)and increasing the levels of mucin and glycoproteins.Furthermore,EA intervention altered the structure of the gut microbiota,resulting in a significant increase in the abundance of beneficial bacteria,such as Rumino-coccaceae and Roseburia.Conclusion EA is a potential adjunct therapy for sepsis-related pulmonary and intestinal injury.The mechanism involves the inhibition of the NLRP3 inflammasome and remodeling of the gut microbiota. 展开更多
关键词 Electroacupuncture Sepsis Acute lung injury Intestinal barrier dysfuntion Gut microbiota NLRP3 inflammation MAPK signaling
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Coping with extremes:diet and phylogeny shape gut microbiota in six passerine species inhabiting the Qinghai-Tibet Plateau 认领 引用
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作者 Yanfeng Sun Xu Liu +8 位作者 Qian Zhang Mo Li Lirong Zuo Fangyuan Liu Dandan Ma Yang Wang Limin Wang Yaotong Hao Dongming Li 《Avian Research》 SCIE CAS CSCD 2026年第1期123-133,共11页
Understanding how diet and host phylogeny shape gut microbiota is fundamental to elucidating host-microbe interactions in extreme environments.The Qinghai-Tibet Plateau(QTP),characterized by harsh conditions,provides ... Understanding how diet and host phylogeny shape gut microbiota is fundamental to elucidating host-microbe interactions in extreme environments.The Qinghai-Tibet Plateau(QTP),characterized by harsh conditions,provides a natural laboratory for examining these relationships among sympatric species.Here,we investigated the dietary composition and gut microbiota of six passerine species inhabiting the QTP,comprising two endemic residents(White-rumped Snowfinch Onychostruthus taczanowskii and Ground Tit Pseudopodoces humilis),two nonendemic residents(Rock Sparrow Petronia petronia and Eurasian Tree Sparrow Passer montanus),and two nonendemic migratory species(Twite Linaria flavirostris and Black Redstart Phoenicurus ochruros),using highthroughput 18S and 16S rRNA sequencing.Our results revealed that dietary composition—dominated by Archaeplastida,Metazoa,Fungi,and the SAR supergroup—exhibited no significant interspecific variation,reflecting a high degree of trophic niche overlap.Although the overall diet was similar across species,the relative abundances of certain dietary components independently influenced specific microbial taxa.In particular,dietary Archaeplastida and Fungi showed phylogeny-independent positive correlations with 16 and 3 microbial genera,respectively,revealing fine-scale diet-microbiota associations.Evidence of phylosymbiosis was detected,as closely related species harbored more similar microbial communities driven by species-specific microbial biomarkers.Notably,our results suggested deterministic processes played a stronger role in endemic species,whereas stochastic community assembly dominated in non-endemic species,indicating distinct assembly mechanisms shaped by biogeographic history.Overall,this study reveals that while dietary similarity promotes convergent trophic niches among sympatric passerines,host phylogeny exerts a stronger influence on gut microbiota composition and assembly.These findings underline the synergistic roles of diet-microbiota interactions and phylosymbiosis dynamics as key adaptive strategies that enable birds to cope with the extreme environments of the QTP. 展开更多
关键词 Dietary components Gut microbiota Host phylogeny Sympatric birds Qinghai-Tibet Plateau
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Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue 认领 引用
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作者 Zi-Xuan Liu Xiao-Yan Liu +4 位作者 Wei-Wei Tan Wei-Bing Zhang Ya-Li Zhang Lie Zheng Yan-Cheng Dai 《World Journal of Gastroenterology》 SCIE CAS 2026年第3期103-127,共25页
BACKGROUND Ulcerative colitis(UC)is a chronic,non-specific inflammatory bowel disease.The gut microbiome undergoes significant changes in UC.Fatigue is a highly prevalent and debilitating extraintestinal symptom of UC... BACKGROUND Ulcerative colitis(UC)is a chronic,non-specific inflammatory bowel disease.The gut microbiome undergoes significant changes in UC.Fatigue is a highly prevalent and debilitating extraintestinal symptom of UC,which negatively affects quality of life.However,its relationship with gut microbes and metabolites remains unclear.AIM To assess the gut microbiota and metabolomic characteristics of patients with UC with fatigue(HUCF).METHODS A total of 120 participants were recruited and divided into four groups(n=30 per group)based on the diagnosis of UC and Fatigue Scale-14 scores:HUCF,UC without fatigue(HUCN),healthy with fatigue(HHF),and healthy without fatigue(HHN).Fresh stool samples were collected for 16S rRNA sequencing and untargeted metabolomic analysis.RESULTS Metabolomic analysis revealed significant differences among the four groups(principal component analysis/partial least squares discriminant analysis,P=0.001),with differential expression of metabolites such as linoleoyl ethanolamide,arachidonoyl ethanolamide,glycocholic acid,and thromboxane(TX).Notably,TX was detected only in the HUCF group.Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed alterations in eicosanoid,tryptophan,and tyrosine metabolism in the HUCF group.Microbial richness and diversity were significantly lower in the HUCF group than in the other three groups.The HUCF group showed enrichment of Hyphomicrobiales,Brucella,Eisenbergiella,Pediococcus,and Sellimonas.The HUCN group showed enrichment of Campylobacter-related taxa.The HHF group showed enrichment of Fusobacterium,Desulfovibrionaceae,and Bilophila.The HHN group showed enrichment of beneficial genera such as Adlercreutzia.Notably,Anaerococcus,a beneficial genus,was enriched in the HUCF group.Correlation analysis indicated that specific microbes(e.g.,Faecalibacterium and Escherichia-Shigella)were associated with the severity of UC and fatigue.CONCLUSION Patients with HUCF exhibit a distinct gut microbial structure and metabolomic profile.The pro-inflammatory metabolite TX and the genus Anaerococcus are uniquely enriched in patients with HUCF,suggesting their potential roles in the development of HUCF.These findings provide novel insights and a theoretical basis for improving the clinical management of HUCF. 展开更多
关键词 Ulcerative colitis Fatigue Gut Microbiota Metabolites Thromboxane Anaerococcus
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Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2,AMPK pathways and reshaping gut microbiota 认领 引用
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作者 Huajie Zhao Liang Liu +6 位作者 Ningning Liu Baoguo Deng Min Li Duan Li Le Jia Ge Wang Fan Yang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1323-1342,共20页
One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column... One novel enzymatic-extractable polysaccharide(ES1)from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.The hepatoprotective ability of ES1 against chronic alcoholic liver disease(ALD)and its underlying mechanism were explored.The results indicated that ES1 could alleviate liver damage in ALD mice by activating sequestosome-1uclear factor E2-related factor 2(P62/Nrf2)pathway to increase antioxidant enzyme activities against oxidative stress,regulating adenosine monophosphate-activated protein kinase(AMPK)pathway to promote fatty acid oxidation and inhibit cholesterol synthesis against lipid metabolism disorders,and improving gut microbiota(increasing the relative abundances of Ligilactobacillus and Akkermansia,and reducing the relative abundances of Enterococcus,Romboutsia,Allobaculum,Coriobacteriaceae_UCG-002,Dubosiella and Faecalibaculum)against intestinal barrier dysfunction.Meantime,structural analysis showed that ES1 with molecular weight of 25.79 kDa was composed ofα-DManp-(1→,→2,6)-α-D-Galp-(1→,→6)-α-D-Galp-(1→,→3)-α-L-Fucp-(1→,andα-D-Glcp-(1→,and its structure was also inferred.Therefore,these data support the application of ES1 as a potential functional food or drug for treating ALD. 展开更多
关键词 Laetiporus sulphureus polysaccharides Alcoholic liver disease Lipid metabolism Oxidative stress Gut microbiota
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Enterococcus hirae QT4713 alleviated DSS-induced colitis by modulating gut microbiota and tryptophan metabolism in mice 认领 引用
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作者 Xueni Fan Zhenjiang Liu +7 位作者 Wei Liu Diantong Li Tingting Zhao Dongxu Wen Xin Li Qi Wang Bin Li Xiaodan Huang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1905-1919,共15页
Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibit... Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibited high anti-inflammatory activity in vitro.After confirming its tolerance to gastrointestinal fluids and safety,we evaluated the effect of E.hirae QT4713 on IBD using a dextran sulfate sodium(DSS)-induced colitis mouse model and analyzed the microbial response through metagenomic and metabolomics.The results indicated that E.hirae QT4713 alleviated colitis symptoms by reducing oxidative stress in the serum and inflammatory cytokine levels in colonic tissue,particularly IL-1β(P<0.05).It also reduced structural damage,inflammatory infiltration,and epithelial cell apoptosis in the colon.Additionally,the strain increased the expression of MUC-2 and occludin in colonic tissue,which helped to protect the colonic barrier.Furthermore,intervention with E.hirae QT4713 enriched beneficial bacteria such as Bifidobacteria and Lactobacillus,increased the levels of butyric acid and propionic acid in the gut(P<0.05),regulated tryptophan metabolism,and promoted the production of its indole derivatives,including 3-indoleacetonitrile,3-indoleacrylic acid,and indole-3-lactic acid(P<0.05),thus alleviating colitis.These findings provide new insights into how probiotics,such as E.hirae QT4713,alleviated colitis in a gut microbiotaryptophan metabolism-dependent manner. 展开更多
关键词 Probiotic Anti-inflammatory Colitis Gut microbiota Tryptophan metabolism
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Reuterin-producing Limosilactobacillus reuteri with glycerol metabolism ameliorates Staphylococcus aureus-induced intestinal inflammation and dysfunction without gut microbiota dependent 认领 引用
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作者 Jinmei Li Kaixiang Zou +4 位作者 Xinrui Li Ke Zhu Yijuan Li Hua Wei Zhihong Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第2期823-835,共13页
Limosilactobacillus reuteri is a vertebrate symbiont that is widely appreciated as being of significant ecological importance for human health.As a unique feature,L.reuteri converts glycerol to the antimicrobial compo... Limosilactobacillus reuteri is a vertebrate symbiont that is widely appreciated as being of significant ecological importance for human health.As a unique feature,L.reuteri converts glycerol to the antimicrobial compound reuterin using enzymes encoded in its propanediol-utilization operon and evolves with host-driven diversification.Reuterin-producing L.reuteri HLRE13 was selectively isolated from poultry previously and confirmed to inhibit the growth of Staphylococcus aureus in vitro.However,it remains unclear whether L.reuteri HLRE13 retains these antagonistic properties when ingested in specific-pathogen-free mice.Here,we investigated the ameliorative effects and potential mechanisms of action of L.reuteri HLRE13 in combination with glycerol on S.aureus-induced infection phenotypes in mice.Firstly,our results confirmed that L.reuteri HLRE13 effectively inhibited the intestinal colonization of S.aureus CMCC26003;Secondly,L.reuteri HLRE13 combined with glycerol could alleviate the intestinal tissues damage caused by S.aureus through increasing the expression of ZO-1,Occludin,and MUC-2,ameliorate the intestinal systemic inflammatory response,and maintain the balance of gut microbiota by increasing the relative abundance of Lactobacillus and reducing the relative abundance of Staphylococcus.Furthermore,the colonization resistance was also found on L.reuteri HLRE13 combined with glycerol against S.aureus in pseudo germ-free mice,and they exerted the similar effects on alleviating intestinal damage and improving immune function.Combining these results,we speculate that reuterin-producing L.reuteri antagonize S.aureus in mice without the gut microbiota-dependent manner.Overall,our findings will provide a theoretical foundation for the scientific cognition of L.reiteri in maintaining intestinal health by producing reuterin. 展开更多
关键词 Limosilactobacillus reuteri Glycerol Reuterin Colonization resistance Intestinal barrier Gut microbiota
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Probiotic Akkermansia muciniphila alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites 认领 引用
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作者 Juan Ni Zhan Yang +11 位作者 Xuewei Sun Qian Cui Ruonan Zhang Han Lu Zihan Wu Jingfeng Zhu Huijuan Mao Kang Liu Chengliang Tang Chunhui Wang Changying Xing Jin Zhu 《Journal of Biomedical Research》 CAS CSCD 2026年第1期76-88,共13页
Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight ... Acute kidney injury(AKI)is a critical condition with limited effective therapies.Akkermansia muciniphila(A.muciniphila)is a probiotic with multiple beneficial effects,including the regulation of epithelial cell tight junctions.Since renal pathophysiology is associated with gut barrier integrity,we hypothesized that A.muciniphila may have preventive effects on AKI.We established a lipopolysaccharide(LPS)-induced AKI mouse model to evaluate the effects of A.muciniphila.Our findings showed that pretreatment with A.muciniphila significantly attenuated kidney injury,as evidenced by reduced serum creatinine and urea nitrogen levels,alongside decreased tubular necrosis and apoptosis.A.muciniphila preserved intestinal barrier integrity and induced marked shifts in gut microbial ecology and the metabolome.A.muciniphila notably induced an increase in the relative abundance of the phylum Proteobacteria while decreasing in that of the phylum Bacteroidetes.At the genus level,Prevotella,Faecalibaculum,Moraxella,and Lactobacillus were more abundant in A.muciniphilapretreated mice.Metabolomic analysis revealed that A.muciniphila altered the gut metabolome,with changes involving pathways such as tyrosine metabolism,alanine/aspartate/glutamate homeostasis,cancer-related carbon flux,and GABAergic synaptic signaling.In conclusion,our findings indicate that A.muciniphila exerts renoprotective effects by modulating the gut-kidney axis,thereby establishing a foundation for future studies to explore the connection between gut microbiota and AKI. 展开更多
关键词 Akkermansia muciniphila acute kidney injury gut-kidney axis metabolomics gut microbiota dysbiosis
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Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis 认领 引用
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作者 Xiao-Fan Song Yi Liu +2 位作者 Qiao-Man Fei Chun-Lan Xu Fan-Pu Ji 《World Journal of Gastroenterology》 SCIE CAS 2026年第1期69-87,共19页
Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)h... Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)has garnered increasing attention.Compared to AP caused by other causes,HTG-AP often has a more subtle onset but is more likely to progress to a severe,critical illness that poses a serious threat to a patient’s life and health.Research suggests a potential connection between the gut microbiota and AP,which could be mediated by bacterial metabolites,immune cells,and inflammatory factors.This is supported by observations of microbial imbalance and higher intestinal permeability in patients with AP.In addition,studies have shown that HTG-induced changes in gut microbiota can worsen AP by negatively impacting the host metabolism,immune response,and function of the intestinal barrier.In this review,we summarize recent clinical and animal studies on the role and mechanism of gut microbiota in the severity of AP aggravated by HTG.The application prospects of the newly proposed microbial-host-isozyme concept are summarized,focusing on its potential for the precision diagnosis and treatment of HTG-AP through gut microbiota regulation. 展开更多
关键词 Gut microbiota Hypertriglyceridemia Gut-pancreas axis Acute pancreatitis Microbial-host-isozyme
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Oral administration of Bacillus spores for mitigation of radiation-induced intestinal injury by regulating gut microbiota 认领 引用
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作者 Cuixia Zheng Yueyue Kong +5 位作者 Xinxin Liu Mengya Niu Shuang Li Yang Liu Lei Wang Chen Hong 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期397-402,共6页
Radiation-induced gastrointestinal toxicity during abdominal/pelvic radiotherapy for solid malignancies remains a global clinical challenge,with current radioprotective agents demonstrating suboptimal efficacy and sys... Radiation-induced gastrointestinal toxicity during abdominal/pelvic radiotherapy for solid malignancies remains a global clinical challenge,with current radioprotective agents demonstrating suboptimal efficacy and systemic toxicity.This study systematically investigates theradioprotective efficacy and mechanisms of purified spores derived from three clinically approved Bacillus species(B.coagulans,B.subtilis,and B.licheniformis).All the three spores exhibit significantly superior X-ray resistance and colonization efficiency to their parent probiotics.Based on this,it is found that these spores significantly reduce X-ray induced injury in intestine and colon tissues by rescuing radiation-induced crypts/villi damage,preventing apoptosis of intestinal epithelial cells,alleviating inflammation level and enhancing the intestinal barrier functions.Moreover,16S ribosomal DNA(rDNA)sequencing results demonstrate that Bacillus spores can inhibit harmful bacteria while increase relative abundance of probiotics,especially Lactobacillus.Consequently,oral administration of these spores obviously alleviates bodyweight loss and promotes weight gain of mice received total abdominal X-ray radiation,among which mice in the BCs(spores of B.coagulans)group achieves full bodyweight recovery.This work may provide promising radioprotectants for efficiently attenuating radiation-induced gastrointestinal syndrome. 展开更多
关键词 Probiotics spores Radiation-induced intestinal injury Oral administration Radioprotection Gut microbiota
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Wuda granules target estrogen receptors and modulate gut microbiota to alleviate postoperative ileus:A multi-omics perspective 认领 引用
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作者 Tao Wang Yi-Hua Xu +11 位作者 Yang-Hui Ou Wen-Jun Xiong Li-Jie Luo Jin Li Yao-Hui Peng Yan Chen Hai-Ping Zeng Yang Yu Hai-Peng Tang Fei Wang Hong-Liang Yao Wei Wang 《World Journal of Gastroenterology》 SCIE CAS 2026年第15期124-143,共20页
BACKGROUND Postoperative ileus(POI)is a common postsurgical complication characterized by impaired gastrointestinal(GI)motility and inflammation.Wuda granules(WDG),derived from the classical simo decoction,have been c... BACKGROUND Postoperative ileus(POI)is a common postsurgical complication characterized by impaired gastrointestinal(GI)motility and inflammation.Wuda granules(WDG),derived from the classical simo decoction,have been clinically used to enhance intestinal motility,normalize bowel activity,relieve obstruction-related discomfort,and promote stool and gas elimination.AIM To investigate the therapeutic effects and underlying mechanisms of WDG in alleviating POI.METHODS A POI mice model was established by standardized intestinal manipulation.GI motility was assessed by measuring gastric emptying,intestinal transit,and serum levels of GI hormones.Histopathological injury,inflammatory cytokines,and intestinal barrier markers were evaluated.A multi-omics strategy was applied,including proteomics to identify WDG-regulated signaling pathways,16S rRNA sequencing to characterize microbiota alterations,gas chromatography-tandem mass spectrometry to quantify gut microbial short-chain fatty acids,and molecular docking to predict interactions between WDG-derived compounds and estrogen receptors(ERs).RESULTS WDG significantly improved GI motility,restored the serum levels of cholecystokinin,gastrin and motilin,and ameliorated the pathological damage in the colon and small intestine.WDG suppressed intestinal inflammation and preserved epithelial barrier integrity by enhancing the expression of tight-junction proteins and reducing Dlactate levels.Proteomics analysis revealed that WDG modulated estrogen signaling-related proteins and pathways.WDG also rebalanced the gut microbiota,particularly enriching beneficial species such as Bacteroides acidifaciens and Parabacteroides goldsteinii,and increased the production of isovaleric acids.Furthermore,WDG upregulated the expression of tyrosine-protein kinase kit,anoctamin-1,neuronal nitric oxide synthase,and ER expression.CONCLUSION WDG alleviates POI by enhancing GI motility,normalizing hormones levels,suppressing inflammation,repairing barrier integrity,and modulating ERs,gut microbiota,and short-chain fatty acids,thereby highlighting a mechanistically relevant inflammation-estrogen-microbiota axis. 展开更多
关键词 Wuda granule Postoperative ileus Anti-inflammatory Estrogen receptors Gut microbiota
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