期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到89篇文章
< 1 2 … 5 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Scutellaria barbata D.Don extracts alleviate SARS-CoV-2 induced acute lung injury by inhibiting virus replication and bi-directional immune modulation 认领 引用 被引量：2
1
作者 Yan Ran Zinuo Chen +4 位作者 Carolina Q.Sacramento Lingyuan Fan Qinghua Cui Lijun Rong Ruikun Du 《Virologica Sinica》 SCIE CAS CSCD 2025年第3期430-438,共9页
The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents.In the present study,we examined the therapeutic effect of the Chinese medicinal herb,Scutel... The emergence of SARS-CoV-2 variants and drug-resistant mutants emphasizes the urgent need to develop novel antiviral agents.In the present study,we examined the therapeutic effect of the Chinese medicinal herb,Scutellaria barbata D.Don(SBD),against SARS-CoV-2 infection both in vitro and in vivo.Using a viral replicon particle(VRP)-based mouse model of SARS-CoV-2 infection,our study revealed that SBD extracts can reduce viral load in mouse lungs and alleviate the viral induced pneumonia.In vitro antiviral determination further validated the direct acting antiviral efficacy of SBD extracts against SARS-CoV-2 replication.Mechanistic studies demonstrated that SBD can act against SARS-CoV2 replication by targeting both 3-chymotrypsin-like and papain-like cysteine proteases,via a combination of multiple active constituents.Moreover,SBD can modulate the host inflammation response in a bi-directional manner,which also contribute to the mitigation of viral induced acute lung injury.In summary,our study provides SBD as a promising therapeutic agent to combat SARS-CoV-2 infections that merit further development. 展开更多
关键词 SARS-CoV-2 Scutellaria barbata D.Don Antiviral Bi-directional immune modulation
暂未订购 下载PDF
Comprehensive pan-cancer analysis of NCOA family members:insights into tumorigenesis,genomic alterations,and immune modulation 认领 引用
2
作者 Xin Li Wan-Rong Li Hao Jin 《Cancer Advances》 2025年第3期1-9,共9页
Background:The nuclear receptor coactivator(NCOA)family,including NCOA1,NCOA2,and NCOA3,is critical in regulating gene expression through interactions with nuclear receptors and other transcription factors.These coact... Background:The nuclear receptor coactivator(NCOA)family,including NCOA1,NCOA2,and NCOA3,is critical in regulating gene expression through interactions with nuclear receptors and other transcription factors.These coactivators are implicated in various cancers,but their comprehensive roles across different cancer types remain poorly understood.Methods:We performed a pan-cancer bioinformatics analysis using data from The Cancer Genome Atlas and the Genotype-Tissue Expression project.We assessed the differential expression,copy number variations,mutations,methylation status,tumor mutation burden,microsatellite instability,and immune cell infiltration associated with NCOA family members across various cancers.Differential expression analysis was conducted using the DESeq2 package.Methylation data were analyzed using the ChAMP package,and immune cell infiltration was estimated using the CIBERSORT algorithm.Results:NCOA1 and NCOA2 were predominantly downregulated in multiple cancers,suggesting potential tumor suppressor roles,whereas NCOA3 was largely upregulated,indicating a consistent oncogenic function.These expression patterns significantly correlated with patient prognosis.Frequent copy number variations,particularly gains,and high mutation rates were observed in NCOA2.NCOA3 demonstrated consistent hypomethylation in tumors,which was associated with increased gene expression.Significant correlations were found between NCOA expression and tumor mutation burden,microsatellite instability,and immune cell infiltration,indicating their involvement in genomic instability and immune modulation.Conclusion:This comprehensive analysis reveals significant alterations in the expression,genomic,and epigenetic profiles of NCOA family members across various cancers.The findings highlight the multifaceted roles of NCOA1,NCOA2,and NCOA3 in tumorigenesis and their potential as biomarkers and therapeutic targets.Future research should focus on elucidating the mechanisms underlying the associations between NCOA expression,genomic alterations,and immune modulation to develop targeted cancer therapies. 展开更多
关键词 NCOA family immune modulation bioinformatics analysis cancer biomarkers
暂未订购 下载PDF
Enteral nutrition and immune modulation of acute pancreatitis 认领 引用 被引量：29
3
作者 Refaat A Hegazi Tiffany De Witt 《World Journal of Gastroenterology》 SCIE CAS 2014年第43期16101-16105,共5页
Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition with... Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition within the first 24-48 h of hospital admission can help improve outcomes compared to parenteral nutrition and no feeding.New research is focusing in on when and what to feed to best improve outcomes for acute pancreatitis patients.Early enteral nutrition have the potential to modulate the immune responses.Despite this consistent evidence of early enteral nutrition in patients with acute pancreatitis,clinical practice continues to vary due to individual clinician preference.Achieving the immune modulating effects of enteral nutrition heavily depend on proper placement of the feeding tube and managing any tube feeding associated complications.The current article reviews the immune modulating effects of enteral nutrition and pro-and prebiotics and suggests some practical tools that help improve the patient adherence and tolerance to the tube feeding.Proper selection of the type of the tube,close monitoring of the tube for its placement,patency and securing its proper placement and routine checking the gastric residual volume could all help improve the outcome.Using peptide-based and high medium chaintriglycerides feeding formulas help improving feeding tolerance. 展开更多
关键词 Enteral nutrition Acute pancreatitis Immune modulating
暂未订购 下载PDF
Immune modulation,immune homeostasis and diseases:Milestone findings by 2025 Nobel Laureates in Physiology or Medicine 认领 引用
4
作者 Bei Jiang Xin Liu Fengmin Lu 《Infectious Diseases & Immunity》 CSCD 2026年第1期1-6,共6页
The 2025 Nobel Prize in Physiology or Medicine honors three scientists for their work in identifying the cellular and molecular basis of peripheral immune tolerance.This mechanism prevents the immune system from attac... The 2025 Nobel Prize in Physiology or Medicine honors three scientists for their work in identifying the cellular and molecular basis of peripheral immune tolerance.This mechanism prevents the immune system from attacking the body while defending against pathogens. 展开更多
关键词 peripheral immune tolerance Nobel Prize immune system diseases immune modulation immune homeostasis
Iridium complex-loaded biomimetic vesicles enable enhanced photodynamic therapy and immune modulation 认领 引用
5
作者 Zhang Xiaohui Tang Xuelin +3 位作者 Lin Bai Rui Zhao Yaohui Chen Xiaohe Tian 《Microsystems & Nanoengineering》 SCIE EI CSCD 2026年第1期463-474,共12页
The strategic integration of microano-engineering with controlled optical responses is pivotal for advancing solid tumor therapy.We have constructed a biomimetic nanosystem via the precise encapsulation of a flexible-... The strategic integration of microano-engineering with controlled optical responses is pivotal for advancing solid tumor therapy.We have constructed a biomimetic nanosystem via the precise encapsulation of a flexible-chain iridium complex(IrC8)within giant plasma membrane vesicles(GPMVs)derived from tumor cells.This microano-scale design leverages the endogenous structure of GPMVs to achieve superior biocompatibility and enhance homologous targeting,resulting in a 4.7%increase in cellular uptake compared to the free complex.The encapsulated IrC8 complex serves as a highly efficient photosensitizer,exhibiting a strong optical response characterized by an aggregation-induced emission enhancement factor(I/I₀)>10 and a high singlet-oxygen quantum yield(ΦΔ=0.18).Upon photoactivation,this system generates reactive oxygen species(ROS)with an 18-fold increase in yield,leading to potent phototoxicity with over 90%tumor cell apoptosis.Furthermore,the systematic integration of the vesicular carrier and the photosensitizer initiates a cascade reaction:the photodynamic effect not only directly eradicates tumor cells but also triggers immunogenic cell death(ICD),leading to potent immune activation.This synergistic combination of targeted delivery,photodynamic therapy,and immune stimulation within a single nanosystem demonstrates a remarkable synergistic therapeutic effect against solid tumors. 展开更多
关键词 micro nano engineering photodynamic therapy immune modulation biomimetic nanosystem enhance homologous targetingresulting superior biocompatibility giant plasma membrane vesicles gpmvs derived controlled optical responses
Dual-layer microneedles with NO/O2releasing for diabetic wound healing via neurogenesis,angiogenesis,and immune modulation 认领 引用 被引量：3
6
作者 Changjiang Liu Kun Liu +6 位作者 Dong Zhang Yuting Liu Yifeng Yu Haifei Kang Xianzhen Dong Honglian Dai Aixi Yu 《Bioactive Materials》 SCIE CSCD 2025年第4期213-228,共16页
Diabetic wounds present multiple functional impairments,including neurovascular dysregulation,oxidative imbalance,and immune dysfunction,making wound healing particularly challenging,while traditional therapeutical st... Diabetic wounds present multiple functional impairments,including neurovascular dysregulation,oxidative imbalance,and immune dysfunction,making wound healing particularly challenging,while traditional therapeutical strategies fail to address these complex issues effectively.Herein,we propose a strategy utilizing duallayer microneedles to deliver therapeutic gases by modulating neurovascular coupling and immune functions for diabetic wound treatment.The microneedle can respond to reactive oxygen species(ROS)in the diabetic microenvironment and subsequently generate oxygen(O2)and nitric oxide(NO).These gases comprehensively promote neuro-vascular regeneration,reduce oxidative stress levels,and attenuate inflammation.In vivo studies demonstrate that the microneedle can accelerate diabetic wound healing by modulating neurovascular regeneration and inflammatory processes.Transcriptomic analyses further validate the involvement of related advantageous signaling pathways.The potential mechanism involves the activation of the PI3K-AKT-mTOR pathway to facilitate autophagy,ultimately accelerating the healing process.Thus,our multifunctional duallayer microneedles provide an effective strategy for treating diabetic wounds. 展开更多
关键词 Microneedles Gas delivery Neurogenesis Angiogenesis Immune modulation Diabetic wounds
Toxoplasma gondii-derived nanocarriers:leveraging protozoan membrane biology for scalable immune modulation and therapeutic delivery 认领 引用
7
作者 Jiating Chen Pengfei Zhang +1 位作者 Hongjuan Peng Jihong Chen 《Bioactive Materials》 SCIE CSCD 2025年第12期602-613,共12页
Cell membrane-derived nanovesicles(CMNVs)are nanoscale lipid bilayer structures obtained from cellular membranes that serve as biomimetic drug delivery platforms,offering immune evasion,targeting,and surface functiona... Cell membrane-derived nanovesicles(CMNVs)are nanoscale lipid bilayer structures obtained from cellular membranes that serve as biomimetic drug delivery platforms,offering immune evasion,targeting,and surface functionalization capabilities.While most CMNVs originate from mammalian cells,Toxoplasma gondii(T.gondii),a genetically tractable protozoan with a structurally distinct membrane,offers a high-yield and underexplored source for producing T.gondii-derived CMNVs(TgCMNVs).These vesicles are obtained from the parasite’s plasma membrane and inner membrane complex and retain unique features including abundant GPI-anchored SRS proteins,phosphatidylthreonine-rich lipids,and an editable genome,enabling versatile engineering via genetic and chemical strategies.We review methods for TgCMNV fabrication,purification,and functionalization,and evaluate their potential in immunomodulation,attenuation of tissue injury,cancer immunotherapy,and self-adjuvanting vaccine design.By combining intrinsic immune engagement with programmable surface architec-ture,TgCMNVs could serve as a complementary and adaptable platform alongside established CMNV systems.Finally,we discuss key translational considerations,including scalable production,immunogenicity control,regulatory compliance,and stability testing,which will be essential for assessing the feasibility of TgCMNVs in clinical applications. 展开更多
关键词 Toxoplasma gondii Cell membrane-derived nanovesicles Genetic engineering of nanovesicles Immune modulation Vaccines Targeted drug delivery
Cu-DHM nanozymes treat flap ischemia-reperfusion injury by amplifying immune modulation in a cascade manner and inhibiting cell apoptosis 认领 引用 被引量：1
8
作者 Xinyu Zhao Shuo Zhang +4 位作者 Min Wang Qingrong Li Xiaolong Wei Xu-Lin Chen Xianwen Wang 《Bioactive Materials》 SCIE CSCD 2025年第9期720-739,共20页
Flap ischemia-reperfusion(I/R)injury triggers intense inflammatory responses and oxidative stress following blood flow restoration,often resulting in tissue dysfunction.Currently,no effective and widely recognized tre... Flap ischemia-reperfusion(I/R)injury triggers intense inflammatory responses and oxidative stress following blood flow restoration,often resulting in tissue dysfunction.Currently,no effective and widely recognized treatment strategies are available in clinical practice.During flap I/R injury,macrophages,T cells,and neu-trophils form a complex regulatory network that jointly participates in inflammatory responses,immune mod-ulation,and tissue repair.Achieving a dynamic balance among these three cell types is critical for flap survival and healing.In this study,a novel Cu-DHM NP metal-polyphenol nanozyme that effectively amplifies immune modulation in a cascade manner,inhibits apoptosis,and treats flap I/R injury was developed.Leveraging their excellent antioxidant properties and SOD-like and CAT-like enzyme activities,Cu-DHM NPs eliminate ROS,alleviate intracellular oxidative stress,protect mitochondrial function,and reduce apoptosis.Moreover,Cu-DHM NPs can regulate the immune microenvironment,cascade and amplify the immunomodulatory effect between macrophages and Naive CD4+T cells,increase the proportions of M2 macrophages and Treg cells,and alleviate inflammation.In animal experiments,Cu-DHM NPs downregulated several pathways associated with inflam-mation and cell death.Cu-DHM NPs inhibited apoptosis,reduced neutrophil infiltration,alleviated inflamma-tion,enhanced angiogenesis,and ultimately improved flap survival rates.This novel metal-polyphenol nanozyme offers a new strategy for treating flap I/R injury by increasing immune modulation and inhibiting apoptosis. 展开更多
关键词 Copper dihydromyricetin Flap Ischemia-reperfusion injury Apoptosis Immune modulation
Microbiome,metabolome,and transcriptome analyses in esophageal squamous cell carcinoma:insights into immune modulation by F.nucleatum 认领 引用
9
作者 Xue Zhang Jing Han +13 位作者 Yudong Wang Li Feng Zhisong Fan Yu Su Wenya Song Lan Wang Long Wang Hui Jin Jiayin Liu Dan Li Guiying Li Yan Liu Jing Zuo Zhiyu Ni 《Protein & Cell》 SCIE CAS CSCD 2025年第6期491-496,共6页
Dear Editor,Esophageal cancer is the seventh most common malignant tumor in China and has the third highest fatality rate worldwide(Siegel et al.,2022).The most common type in China is esophageal squamous cell carcino... Dear Editor,Esophageal cancer is the seventh most common malignant tumor in China and has the third highest fatality rate worldwide(Siegel et al.,2022).The most common type in China is esophageal squamous cell carcinoma(ESCC),which has shown a promising response to immune checkpoint inhibitors(Doki et al.,2022;Sun et al.,2021).However,challenges remain in effectively using immunotherapy due to varying patient responses and difficulties in identifying suitable candidates. 展开更多
关键词 esophageal squamous cell carcinoma immune checkpoint inhibitors doki transcriptome nucleatum immune modulation malignant tumor esophageal squamous cell carcinoma escc which microbiome
暂未订购 下载PDF
Engineered cell-biomimetic nanosystems for anti-inflammatory therapy:Targeting,neutralization and immunomodulation 认领 引用
10
作者 Ruiyao Liu Wuting Dai +2 位作者 Wenbo Zhou Weilin Li Yuan Yu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2026年第6期3506-3539,共34页
Inflammation is a complex and dynamic immune response triggered by tissue injury or pathogen invasion,playing a critical role in restoring tissue homeostasis.However,excessive inflammation can lead to tissue damage an... Inflammation is a complex and dynamic immune response triggered by tissue injury or pathogen invasion,playing a critical role in restoring tissue homeostasis.However,excessive inflammation can lead to tissue damage and exacerbate the progression of various diseases.Issues such as off-target effects and insufficient dynamic regulation pose key challenges to precise modulation of complex inflammatory processes,thereby enhancing efficacy while minimizing adverse effects.Engineered cell-biomimetic nanosystems(ECNs),including membrane-coated nanoparticles,extracellular vesicles(ECVs),and cell-nanoparticle hybrids,are highly adaptable biomimetic platforms with tunable physicochemical properties.Beyond carrier functions,ECNs are capable of actively responding to inflammation-related targets and interacting with the immune microenvironment,thereby promoting the dynamic regulation of inflammation.This review summarizes recent advances in ECNs,with an emphasis on targeting mechanisms and key strategies for inflammatory intervention.These include precise targeting of inflamed tissues,biological neutralization of toxins and overexpressed inflammatory factors to interrupt the inflammatory cascade,and immunomodulatory functions that balance immune responses to achieve activation or suppression.Physical,chemical,and biological engineering strategies for modifying cells and cell membranes for inflammation targeting are also discussed.As an emerging platform for targeted drug delivery and immune regulation,ECNs provide innovative technological approaches for inflammation therapy. 展开更多
关键词 Cell-biomimetic nanosystem Engineered cell/cell membrane Inflammation Microenvironment Targeted drug delivery Biological neutralization Immune modulation
暂未订购 下载PDF
Fermentation of Luffa cylindrica by Lactiplantibacillus plantarum P101 enhanced functional properties:Insights into immune modulation,intestinal barrier repair,and intestinal microbiota regulation 认领 引用 被引量：4
11
作者 Xinrong Wang Xiaowei Xu +1 位作者 Jinfeng Zhang Hengyi Xu 《Food Bioscience》 SCIE 2024年第4期2576-2588,共13页
Luffa cylindrica is a multifunctional plant resource with excellent but little-known functional properties,limited by its low processing and utilization rates.The emerging probiotic fermentation processing is an effic... Luffa cylindrica is a multifunctional plant resource with excellent but little-known functional properties,limited by its low processing and utilization rates.The emerging probiotic fermentation processing is an efficient and convenient way to improve the utilization rate of fruits and vegetables.To investigate the impact of probiotic fermentation on the functional properties of Luffa cylindrica,we fermented Luffa cylindrica with Lactiplantibacillus plantarum P101 and compared the intervention effects of Luffa cylindrica juice(LJ)and Luffa cylindrica fermentation broth(LF)on the damage caused by cyclophosphamide(CTX).After 14 days of intervention with LJ or LF,we collected samples from the thymus,spleen,blood,ileum,and cecum contents from BALB/C mice for subsequent analysis.The results indicate that LF provides better relief from CTX-induced damage than LJ.The main adverse effects caused by immune dysregulation,thymic atrophy,decreased blood leukocyte(WBC)count,and intestinal cytokine levels,were further improved by LF intervention.In addition,under the intervention of LF,intestinal epithelial cells and crypts were further protected,and their tight junction protein expression and mucus secretion were also promoted.Intestinal microbial dysbiosis,positively correlated with intestinal barrier disruption and immunosuppression,was also further alleviated by LF intervention.In summary,fermentation significantly enhanced immune modulation,intestinal barrier repair,and intestinal microbiota regulation of Luffa cylindrica.The results of our study may help people realize the little-known valuable functional properties of Luffa cylindrica,and may be expected to expand the types of functional foods. 展开更多
关键词 Luffa cylindrica fermentation broth Cyclophosphamide Immune modulation Intestinal barrier repair Intestinal microbiota regulation
Tumor-derived exosomal miR-425-5p and miR-135b-3p enhance colorectal cancer progression through immune suppression and vascular permeability promotion 认领 引用 被引量：1
12
作者 Chun-Zai Feng Si-Quan Zhong +3 位作者 Shao-Wei Ye Zheng Zheng Hao Sun Shi-Hai Zhou 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第6期423-438,共16页
BACKGROUND Colorectal cancer(CRC)is a leading cause of cancer-related morbidity and mor-tality globally.Exosomal microRNAs(miRNAs)are known to modulate tumor progression by influencing immune responses and vascular dy... BACKGROUND Colorectal cancer(CRC)is a leading cause of cancer-related morbidity and mor-tality globally.Exosomal microRNAs(miRNAs)are known to modulate tumor progression by influencing immune responses and vascular dynamics.However,the roles of specific exosomal miRNAs,such as miR-425-5p and miR-135b-3p,in CRC remain unclear.AIM To explore the specific roles and underlying mechanisms of exosomal miR-425-5p and miR-135b-3p in CRC progression.METHODS Differentially expressed miRNAs were identified through microarray analysis of exosomes isolated from CRC tissues and adjacent normal mucosa.Functional roles of miR-425-5p and miR-135b-3p were evaluated in vitro using macrophage polarization,T cell differentiation,and vascular permeability assays,as well as in vivo tumor formation and metastasis experiments in nude mice.Validation expe-riments were performed using CRC cell lines(HCT116 and SW620).RESULTS Exosomal miR-425-5p and miR-135b-3p were significantly upregulated in CRC compared to normal tissues.Functional studies revealed that miR-425-5p promo-tes macrophage M2-like polarization and suppresses T cell proinflammatory responses,while miR-135b-3p enhances vascular permeability and angiogenesis.Inhibition of these miRNAs in CRC cell-derived exosomes significantly supp-ressed tumor growth and metastasis in nude mice,reprogramming the tumor microenvironment toward reduced angiogenesis and enhanced immune acti-vation.Combined inhibition of both miRNAs resulted in the most pronounced effects.CONCLUSION Exosomal miR-425-5p and miR-135b-3p drive CRC progression by promoting immune suppression and vascular permeability.Their inhibition offers a promising strategy for modulating the tumor microenvironment and limiting CRC metastasis. 展开更多
关键词 Colorectal cancer Exosomes MiR-425-5p MiR-135b-3p Immune modulation Vascular permeability
暂未订购 下载PDF
Molecular iron-oxo clusters ameliorate sepsis via enhancing humoral immune response 认领 引用
13
作者 Ying Wang Jiaqi Lv +4 位作者 Song Liang Yingdong Xie Yuan Tian Dong Li Hong-Ying Zang 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第11期550-556,共7页
Metal-based antimicrobial materials have been extensively studied and applied over decades.While these materials are notably characterized by their superior antibacterial performance and low propensity to induce drug ... Metal-based antimicrobial materials have been extensively studied and applied over decades.While these materials are notably characterized by their superior antibacterial performance and low propensity to induce drug resistance,critical limitations such as inherent cytotoxicity,poor solubility,and instability in aqueous solution remain significant challenges requiring systematic optimization.In this study,we synthesized water-soluble molecular iron-oxo clusters(MIC)with excellent biosafety and stability of aqueous solution.Our findings demonstrate that MIC exhibits marked therapeutic efficacy in cecal ligation and puncture induced sepsis models,a critical validation given sepsis'etiology as a life-threatening infection mediated systemic inflammatory syndrome.MIC combats bacteria by enhancing humoral immune responsiveness.MIC significantly improved the survival rate,reduced bacterial burden,stabilized body temperature,and modulated cytokine profiles in mice with sepsis.Further investigations revealed that MIC promotes B cells proliferation and oxidative phosphorylation,and mitigates mitochondrial damage and apoptosis in B cells,suggesting its role in modulating cellular metabolism.RNA sequencing analysis demonstrated that MIC exerts its effects by influencing key pathways involved in humoral immunity,inflammatory responses,and metabolic adaptation.These findings establish MIC as a novel therapeutic agent for regulating immune responses in sepsis,providing innovative strategies to improve recovery from this life-threatening condition. 展开更多
关键词 Sepsis Molecular iron-oxo clusters Immune modulation Humoral immune response Metal-based antibacterial materials
暂未订购 下载PDF
The Crossroads of Neurology and Immunology: Exploring the Intricacies of Neuroimmune Interactions 认领 引用
14
作者 Isra Omar Ahmed Alakhras +1 位作者 Samahir Mutwali Moiz Bakhiet 《World Journal of Neuroscience》 CAS 2025年第1期42-57,共16页
The concept of neuroimmune interactions has shown significant advancements over the years. Modern research has revealed many areas of connection between fields, which were previously viewed as distinct disciplines. Fo... The concept of neuroimmune interactions has shown significant advancements over the years. Modern research has revealed many areas of connection between fields, which were previously viewed as distinct disciplines. For example, the nervous system can sense changes in the external environment and convey these changes through molecules and mediators with receptors in the immune system to modulate immune responses. Neuromediators can act on different receptors in the same group of cells, producing antipodal effects. Identification of the anti-inflammatory role of glucocorticoids highlighted that the body functions properly in an integrated manner. These interactions and crosstalk are not unidirectional, as the immune system can also influence various aspects of the nervous system, such as synaptic plasticity and fever. Strict integration of neuro-immuno-endocrine circuits is indispensable for homeostasis. Understanding these circuits and molecules can lead to advances in the understanding of various immune diseases, which will offer promising therapeutic options. 展开更多
关键词 Neuroimmune Interactions Neuromediators Synaptic Plasticity Homeostasis Immune Modulation
暂未订购 下载PDF
Design principles of nanomaterials for cancer immunotherapy:a mechanistic framework across the cancer immunity cycle 认领 引用
15
作者 Yating Bai Zhihao Lan +2 位作者 Nana Feng Zhanzhan Zhang Yang Liu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第4期541-558,共18页
Cancer immunotherapy has revolutionized oncology by harnessing the immune system to eliminate malignant cells,yet its efficacy remains constrained by insufficient antigen presentation,limited T cell infiltration,and t... Cancer immunotherapy has revolutionized oncology by harnessing the immune system to eliminate malignant cells,yet its efficacy remains constrained by insufficient antigen presentation,limited T cell infiltration,and the immunosuppressive tumor microenvironment(TME).Nanotechnology provides strategies to address these barriers by enabling the precise delivery of antigens,adjuvants,cytokines,checkpoint inhibitors,and nucleic acids,while protecting labile cargos and allowing for controlled release.Beyond serving as carriers,nanoparticles can regulate antitumor immunity by enhancing antigen presentation,promoting T cell priming and infiltration,and remodeling the TME.This review outlines key physiological barriers to in vivo nanoparticle delivery and the corresponding engineering optimization strategies,and systematically summarizes representative advances in using nanomaterials to enhance antigen presentation,promote T cell priming and intratumoral infiltration,and remodel the tumor microenvironment.We further discuss major translational limitations,including heterogeneous tumor accumulation,intracellular trafficking bottlenecks,safety considerations,and manufacturing consistency,and finally highlight the realizable potential of nano-immunotherapy to improve both the efficacy and specificity of cancer immunotherapy. 展开更多
关键词 Cancer immunotherapy nanoparticles tumor microenvironment T cell activation immune modulation
暂未订购 下载PDF
Vitamin D and inflammatory bowel diseases 认领 引用
16
作者 Ioannis Bontsiou Georgios Tzikos +5 位作者 Angeliki Chorti Angeliki Vouchara Alexandra Menni Maria Papaioannou Katerina Kotzampassi Theodosios S Papavramidis 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期34-45,共12页
Crohn’s disease and ulcerative colitis are the two main gastrointestinal disorders that constitute inflammatory bowel diseases(IBD).Their etiology is still unknown;however,their pathogenesis is believed to be rooted ... Crohn’s disease and ulcerative colitis are the two main gastrointestinal disorders that constitute inflammatory bowel diseases(IBD).Their etiology is still unknown;however,their pathogenesis is believed to be rooted in a disorganized immune response.Targeted research was conducted in the PubMed,Scopus and EMBASE databases,including relevant peer-reviewed articles published from November 1994 to June 2025.In the past decade,vitamin D(VD)has been established as a major regulator of the immune system,including the specific environment of the digestive system,beyond its role in calcium and phosphate homeostasis.There is strong evidence that VD supports epithelial barrier integrity by influencing gut microbiome composition.On the other hand,VD deficiency is very common among patients with IBD and may contribute to disease activity,morbidity(including the need for surgery and risk for colorectal cancer),and impaired health-related quality of life.Moreover,VD deficiency seems to increase the risk of malignancy in patients with IBD.However,it remains controversial whether VD deficiency is a consequence of the disease or is implicated in its pathogenesis.Finally,the therapeutic role of VD in IBD remains to be established. 展开更多
关键词 Vitamin D Inflammatory bowel disease Crohn’s disease Ulcerative colitis Pathogenesis Review Immune modulation Vitamin D receptor signaling Disease activity Vitamin D supplementation
暂未订购 下载PDF
Probiotic modulation of dendritic cells co-cultured with intestinal epithelial cells 认领 引用 被引量：10
17
作者 Ji Yeun Kim Myeong Soo Park Geun Eog Ji 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第12期1308-1318,共11页
AIM： To investigate cytokine production and cell surface phenotypes of dendritic cells （DC） in the presence of epithelial cells stimulated by probiotics.METHODS： Mouse DC were cultured alone or together with mouse... AIM： To investigate cytokine production and cell surface phenotypes of dendritic cells （DC） in the presence of epithelial cells stimulated by probiotics.METHODS： Mouse DC were cultured alone or together with mouse epithelial cell monolayers in normal or in- verted systems and were stimulated with heat-killed probiotic bacteria, Bifidobacterium lactis ADO 11 （BL）, Bifidobacterium bilfidum BGN4 （BB）, Lactobacillus casei IBS041 （LC）, and Lactobacillus acidophilus AD031 （LA）, for 12 h. Cytokine levels in the culture supernatants were determined by enzyme-linked immunosorbent as say and phenotypic analysis of DC was investigated by flow cytometry.RESULTS： BB and LC in singlecultured DC increased the expression of I-Ad, CD86 and CD40 （I-Ad, 18.51 vs 30.88, 46.11, CD86, 62.74 vs 92.7, 104.12; CD40, 0.67 vs 6.39, 3.37, P 〈 0.05）. All of the experimental probiot-ics increased the production of inflammatory cytokines, interleukin （IL）-6 and tumor necrosis factor （TNF）-α. However, in the normal coculture systems, LC and LA decreased the expression of I-A^α （39.46 vs 30.32, 33.26, P 〈 0.05）, and none of the experimental probiotics increased the levels of IL-6 or TNF-α. In the inverted coculture systems, LC decreased the expression of CD40 （1.36 vs -2.27, P 〈 0.05）, and all of the experimental probiotics decreased the levels of IL-6. In addition, BL increased the production of IL-10 （103.8 vs 166.0, P 〈 0.05） and LC and LA increased transforming growth factor-13 secretion （235.9 vs 618.9, 607.6, P 〈 0.05）.CONCLUSION： These results suggest that specific pro- biotic strains exert differential immune modulation mediated by the interaction of dendritic cells and epithelial cells in the homeostasis of gastrointestinal tract. 展开更多
关键词 Dendritic cells Intestinal epithelial cells Pro-biotics Co-culture Immune modulation
暂未订购 下载PDF
Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus 认领 引用 被引量：22
18
作者 LI Hong-quan Lloyd Reeve-Johnson WANGJun-dong 《Agricultural Sciences in China》 2007年第11期1402-1408,共7页
Two hundred and forty specific pathogen free leghorn chickens were randomly divided into four groups and reared in isolated pens. The tested chickens were negative to infectious bursal disease virus （IBDV） at 25 d o... Two hundred and forty specific pathogen free leghorn chickens were randomly divided into four groups and reared in isolated pens. The tested chickens were negative to infectious bursal disease virus （IBDV） at 25 d old. Group 1 was treated with saline, whereas Groups 2, 3, and 4 were inoculated with 0.3 mL IBDV suspension intranasally the next day. Groups 3 and 4 were also administered with Astragalus polysaccharides （APS） intramuscularly twice daily at 5 or 10 mg kg-1 BW, respectively, until 31 d old. The erythrocyte-C3b receptor rosette rate （E-C3bRR） and the erythrocyte-C3b immune complex rosette rate （E-ICRR） were measured at 25, 29, 32, 35, and 38 d old. The results showed that IBDV significantly reduced E-C3bRR and E-ICRR when compared with the control group （P 〈 0.05）, while simultaneous administration of APS with 1BDV maintained E-C3bRR at similar levels to the control group （P 〉 0.05） and increased E-ICRR when compared with the control group and the group non-treated with APS （P 〈 0.05）. APS treatment reduced the morbidity and mortality of chickens inoculated with IBDV （P 〈 0.05）. The results suggest that APS may enhance the immune adherence of chickens erythrocytes by affecting the activity and/or the number of complement receptors on the erythrocyte membrane. These findings can be beneficial in providing an understanding of the basic mechanisms required for the rational application of APS in modern medicine. 展开更多
关键词 Astragalus polysaccharides chicken infectious bursal disease virus （IBDV） erythrocyte immune modulation herbal therapy
暂未订购 下载PDF
Radiotherapy as an immune checkpoint blockade combination strategy for hepatocellular carcinoma 认领 引用 被引量：3
19
作者 Byung Min Lee Jinsil Seong 《World Journal of Gastroenterology》 SCIE CAS 2021年第10期919-927,共9页
In the immune oncology era,the clinical efficacy of immune checkpoint inhibitors(ICIs)against most solid cancers is well known.In hepatocellular carcinoma,the recent success of combination therapy with targeting agent... In the immune oncology era,the clinical efficacy of immune checkpoint inhibitors(ICIs)against most solid cancers is well known.In hepatocellular carcinoma,the recent success of combination therapy with targeting agents has accelerated the search for novel combination strategies.Radiotherapy(RT),an attractive modality,can be combined with ICIs,which act as strong modulators of the tumor immune microenvironment.Herein,we discuss immune modulation caused by radiation and the current trials of RT-ICI combination treatment as well as future perspectives. 展开更多
关键词 Hepatocellular carcinoma Immune checkpoint inhibitor Radiotherapy Immune modulation Tumor microenvironment Immune oncology
暂未订购 下载PDF
Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin‑producing E.coli challenged weaned piglets 认领 引用
20
作者 Matthias Dierick Ruben Ongena +2 位作者 Daisy Vanrompay Bert Devriendt Eric Cox 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第3期1278-1291,共14页
Background Post-weaned piglets suffer from F18+Escherichia coli(E.coli)infections resulting in post-weaning diar-rhoea or oedema disease.Frequently used management strategies,including colistin and zinc oxide,have con... Background Post-weaned piglets suffer from F18+Escherichia coli(E.coli)infections resulting in post-weaning diar-rhoea or oedema disease.Frequently used management strategies,including colistin and zinc oxide,have contrib-uted to the emergence and spread of antimicrobial resistance.Novel antimicrobials capable of directly interacting with pathogens and modulating the host immune responses are being investigated.Lactoferrin has shown promising results against porcine enterotoxigenic E.coli strains,both in vitro and in vivo.Results We investigated the influence of bovine lactoferrin(bLF)on the microbiome of healthy and infected weaned piglets.Additionally,we assessed whether bLF influenced the immune responses upon Shiga toxin-producing E.coli(STEC)infection.Therefore,2 in vivo trials were conducted:a microbiome trial and a challenge infection trial,using an F18+STEC strain.BLF did not affect theα-andβ-diversity.However,bLF groups showed a higher relative abundance(RA)for the Actinobacteria phylum and the Bifidobacterium genus in the ileal mucosa.When analysing the immune response upon infection,the STEC group exhibited a significant increase in F18-specific IgG serum levels,whereas this response was absent in the bLF group.Conclusion Taken together,the oral administration of bLF did not have a notable impact on theα-andβ-diversity of the gut microbiome in weaned piglets.Nevertheless,it did increase the RA of the Actinobacteria phylum and Bifi-dobacterium genus,which have previously been shown to play an important role in maintaining gut homeostasis.Furthermore,bLF administration during STEC infection resulted in the absence of F18-specific serum IgG responses. 展开更多
关键词 E.coli Immune modulation Lactoferrin Microbiome
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 5 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈