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Effect of Acupuncture at Points of the Bladder Meridian of Foot-Taiyang on Serum Inflammatory Factors in Rabbit Models of Cervical Spondylosis 认领 引用
1
作者 Wenrong Yang Shu Zhao +3 位作者 Jincai Liu Dan Wang Zhijun Chen Zhigang Zhao 《Journal of Clinical and Nursing Research》 2026年第1期1-12,共12页
Objective:Based on the theory of“Taiyang governs tendons”,to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of ce... Objective:Based on the theory of“Taiyang governs tendons”,to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of cervical spondylosis.Methods:Thirty New Zealand white rabbits were randomly divided into a blank group,a model group,and a treatment group,with 10 rabbits in each group.The models of cervical spondylosis in the model group and treatment group were established by long-term head-down flexion combined with cold-damp stimulation.After modeling,the treatment group received acupuncture at three points(Kunlun,Weizhong,and Feishu)on the Bladder Meridian of Foot-Taiyang,once a day for 20 minutes each time,for 14 consecutive days;the model group and blank group received no therapeutic intervention.After the intervention,cardiac blood was collected from all rabbits to detect the expression levels of serum inflammatory factors IL-6,TNF-α,and IL-1β.Meanwhile,cervical muscle tissue was collected,stained with HE,and the morphological changes of the posterior cervical muscle tissue in each group were observed under an optical microscope.Results:After modeling,the levels of inflammatory factors in the serum of rabbits in the model group and treatment group were significantly increased compared with those before modeling,with a statistically significant difference(p<0.01).After intervention,the serum inflammatory factors in the treatment group decreased significantly compared with those in the model group,and the difference was statistically significant(p<0.01).Conclusion:Acupuncture at points of the Bladder Meridian of Foot-Taiyang in rabbit models of cervical spondylosis can reduce the serum levels of inflammatory factors TNF-α,IL-1β,and IL-6. 展开更多
关键词 Cervical spondylosis Bladder meridian of foot-Taiyang Acupuncture Inflammatory factors
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Comparison of the effects of preserving skin bridge incision radical surgery and catheter drainage incision radical surgery in improving inflammatory factors in patients with perianal abscess 认领 引用
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作者 ZHANG Huizhen 《外文科技期刊数据库（文摘版）医药卫生》 2026年第2期094-098,共5页
Objective To compare the clinical efficacy of skin bridge preservation incision radical surgery and catheter drainage incision radical surgery in the treatment of perianal abscess patients, and their effects on the le... Objective To compare the clinical efficacy of skin bridge preservation incision radical surgery and catheter drainage incision radical surgery in the treatment of perianal abscess patients, and their effects on the levels of inflammatory factors (C-reactive protein, interleukin-6), in order to provide a basis for optimizing clinical treatment plans. Method: A total of 58 patients with perianal abscess admitted between January 2022 and December 2024 were randomly divided into two groups: Group A (30 cases) underwent skin bridge preservation incision radical surgery and Group B (30 cases) underwent catheter drainage incision radical surgery. Measure the levels of inflammatory factors (C-reactive protein, interleukin-6) in two groups of patients before and one week after surgery, and record the incidence of complications and clinical efficacy. The results showed that the group undergoing skin bridge incision radical surgery had a better reduction in inflammatory factor levels and incidence of postoperative complications compared to the group undergoing catheter drainage incision radical surgery (P<0.05). Conclusion: Retaining skin bridge incision radical surgery has significant advantages in improving the levels of inflammatory factors and reducing postoperative complications in patients with perianal abscess. Although the clinical efficacy of the two surgical methods is similar, retaining skin bridge incision radical surgery shows better results in postoperative recovery and inflammation control, and is worthy of promotion and application in clinical practice. 展开更多
关键词 perianal abscess Preservation of skin bridge incision radical surgery Placement of drainage tube incision and radical surgery Inflammatory factors clinical efficacy
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Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults 认领 引用
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作者 Xiaojie Guo Huimin Ren +5 位作者 Jiran Zhang Xiao Ma Shilu Tong Song Tang Chen Mao Xiaoming Shi 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第2期144-153,共10页
Objective To examine the mechanistic of organochlorine-associated changes in lung function.Methods This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth period.Personal exposure t... Objective To examine the mechanistic of organochlorine-associated changes in lung function.Methods This study investigated 76 healthy older adults in Jinan,Shandong Province,over a fivemonth period.Personal exposure to organochlorines was quantified using wearable passive samplers,while inflammatory factors and thyroid hormones were analyzed from blood samples.Participants’lung function was evaluated.After stratifying participants according to their thyroid hormone levels,we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone groups.Mediation analysis was further conducted to elucidate the relationships among organochlorine exposures,inflammatory factors,and lung function.Results Bis(2-chloro-1-methylethyl)ether(BCIE),was negatively associated with forced vital capacity(FVC,–2.05%,95%CI:–3.11%to–0.97%),and associated with changes in inflammatory factors such as interleukin(IL)-2,IL-7,IL-8,and IL-13 in the low thyroid hormone group.The mediation analysis indicated a mediating effect of IL-2(15.63%,95%CI:0.91%to 44.64%)and IL-13(13.94%,95%CI:0.52%to 41.07%)in the association between BCIE exposure and FVC.Conclusion Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels,with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function. 展开更多
关键词 Healthy older adults Inflammatory factors Lung function Organochlorines Thyroid hormones
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Effect of extracorporeal membrane oxygenation combined with hemoperfusion on inflammatory factors in patients with cardiogenic shock 认领 引用
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作者 Jing-Yan Hao Shi-Fu Wang +6 位作者 Qin Yang Wei Wang Zhuo-Xian Zhao Shan Guo Ying Zhou Fei Dong Wen-Hua Lin 《World Journal of Cardiology》 2025年第8期72-79,共8页
BACKGROUND Data on adsorptive extracorporeal membrane oxygenation(ECMO)(combined with HA380 hemoperfusion column)on the inflammatory factors in patients with cardiogenic shock(CS)remains limited.AIM To investigate the... BACKGROUND Data on adsorptive extracorporeal membrane oxygenation(ECMO)(combined with HA380 hemoperfusion column)on the inflammatory factors in patients with cardiogenic shock(CS)remains limited.AIM To investigate the effects of adsorptive ECMO on the inflammatory factors in patients with CS.METHODS A retrospective analysis was performed on 81 patients with CS caused by acute myocardial infarction,fulminant myocarditis,or cardiac surgery who required venoarterial ECMO support at TEDA International Cardiovascular Hospital from December 2020 to December 2024.Patients were divided into the conventional ECMO group(42 cases)and the adsorptive ECMO group(ECMO combined with hemoperfusion,39 cases).The adsorptive ECMO group received 2 columns of HA380 initiation on the first day(the first column connected within 2 hours of ECMO and the second after 12 hours of ECMO),followed by 1 column each day,with each column used for 4–6 hours,totaling 24–30 hours of treatment.Baseline data were compared between the two groups:Inflammatory factor levels(at 0,6,12,24,48,and 72 hours after ECMO or hemoperfusion initiation);ECMO support duration;successful weaning rate;continuous renal replacement therapy(CRRT)utilization;Sequential Organ Failure Assessment(SOFA)score;Vasoactive-Inotropic Score(VIS);systemic inflammatory response syndrome(SIRS)incidence;and in-hospital survival and 30-/90-day survival after discharge.RESULTS The adsorptive ECMO group showed significantly lower levels of C-reactive protein,interleukin(IL)-6,tumor necrosis factor(TNF)-α,and lactate from 6 to 72 hours compared with the conventional ECMO group(all P0.05).CONCLUSION Adsorptive ECMO efficiently clears IL-6 and TNF-α,significantly improving ECMO weaning success rate and hemodynamics.However,it has no significant impact on survival,and its efficacy requires validation through prospective studies. 展开更多
关键词 Adsorptive extracorporeal membrane oxygenation Cardiogenic shock Inflammatory factors Hemoperfusion column Therapeutic outcomes
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Hericium erinaceus polysaccharides(HEP)protect against gastric mucosa injury via modulating inflammatory factors,promoting antioxidant activity,and activating the PI3K-AKT pathway 认领 引用
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作者 Weijun Cui Xiangyang Zhu +3 位作者 Xueping Li Xinling Song Le Jia Chen Zhang 《Food Innovation and Advances》 2025年第3期284-292,共9页
Gastric mucosal injury(GMI)is a common pathology affecting many people around the world.Hericium erinaceus polysaccharides(HEP)have various biological activities,such as anti-inflammatory,anti-oxidation,and protection... Gastric mucosal injury(GMI)is a common pathology affecting many people around the world.Hericium erinaceus polysaccharides(HEP)have various biological activities,such as anti-inflammatory,anti-oxidation,and protection of the gastrointestinal tract.HEP-1,a low molecular weight polysaccharide(1.67×104Da)isolated from Hericium erinaceus,is composed of→6)-β-D-Glcp-(1→,→3)-β-D-Glcp-(1→,β-D-Glcp-(1→,and→3,6)-β-D-Glcp-(1→.However,whether HEP has preventive efficacy against GMI is unknown.This study investigated the intervention effect and potential mechanism of HEP-1 on GMI.Mice treated with HEP-1 for two weeks were treated with ethanol to induce gastric mucosal damage.The gastric mucosal tissue pathology,gastric tissue inflammatory factors,and gastric oxidative stress function were evaluated.The results showed that HEP-1 increased the activity of antioxidant enzymes,reduced the release of inflammatory factors,promoted the production of nitric oxide(NO),inhibited the production of endothelin-1(ET-1),and increased the blood flow of gastric mucosa to maintain the defensive function of the gastric mucosa.HEP-1 also activated the PI3K-AKT signaling pathway,increased the expression of endothelial nitric oxide synthase(eNOS),promoted the expression of serum and glucocorticoid-induced kinase(SGK),and enhanced the biosynthesis of epidermal growth factor(EGF)and vascular endothelial growth factor(VEGF),thereby facilitating the repair and healing of gastric mucosal injury(GMI).Therefore,HEP-1 has the potential to preserve the integrity of the gastric mucosa and is anticipated to be a key bioactive ingredient in the prevention and repair of GMI. 展开更多
关键词 gastric mucosal injury gmi Inflammatory factors low molecular weight polysaccharide da isolated Hep Antioxidant activity erinaceus polysaccharides hep hericium erinaceusis Gastric mucosa injury
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Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk 认领 引用
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作者 Bing Chen Jun Chen +3 位作者 Zhi-Tao Chen Zhang-Peng Feng Han-Bei Lv Guo-Ping Jiang 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第7期380-391,共12页
BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver cancer subtype with limited effective treatment options.Emerging evidence suggests that inflammatory factors play a critical role in ICC progr... BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver cancer subtype with limited effective treatment options.Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment(TME).However,causal relationships between specific inflammatory factors and ICC risk remain unclear.AIM To investigate the causal relationship between inflammatory factors and ICC.METHODS This study used Mendelian randomization(MR)and Bayesian weighted MR(BWMR)analyses to investigate the causal impact of inflammatory factors on ICC risk.Genetic data from genome-wide association studies were utilized to identify and validate instrumental variables for 91 inflammatory factors,followed by sensitivity analyses to ensure robustness.RESULTS MR analysis identified significant associations between elevated levels of artemin and matrix metalloproteinase(MMP)-10 and increased ICC risk.BWMR and meta-MR analysis results validated these associations.Sensitivity analyses confirmed the stability of these findings,indicating that specific inflammatory factors may contribute causally to ICC development.CONCLUSION This study provides evidence that certain inflammatory factors,particularly artemin and MMP-10,are causally linked to ICC risk,identifying them as potential risk factors and therapeutic targeting.These findings enhance the understanding of the inflammatory components of the TME in ICC,supporting the development of targeted intervention strategies. 展开更多
关键词 Intrahepatic cholangiocarcinoma Mendelian randomization Bayesian weighted Mendelian randomization Inflammatory factors Tumor microenvironment
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Relationship between inflammatory factors,lactic acid levels,acute skin failure,bad mood,and sleep quality 认领 引用 被引量：5
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作者 Yu-Fei Liu Wen Cong +2 位作者 Chang-Ming Zhou Yang Yu Xin-Jie Zhang 《World Journal of Psychiatry》 SCIE 2025年第4期113-123,共11页
BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft... BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF. 展开更多
关键词 Septic shock Acute skin failure Inflammatory factors Lactic acid level Degree of acute skin failure Bad mood
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The Study on the Effect of Huoxue Tongmai Capsules Combined with Edaravone Right Camphor on Serum Inflammatory Factors and Its Clinical Efficacy in Patients with Acute Cerebral Infarction 认领 引用 被引量：3
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作者 Yaojie Cai Yan Chen Yuping He 《Journal of Biosciences and Medicines》 2025年第2期148-157,共10页
Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy... Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy on serum inflammatory factors. Methods: In this study, 90 patients with acute cerebral infarction hospitalized in Zhuji People’s Hospital from December 2023 to December 2024 were selected and divided into two groups of 45 patients in each group. The control group used standard medical treatment, and the treatment group compared the changes of serum inflammatory factors IL-CRP, TNF-α, and Hcy with Huoxue Tongmai capsule for 7 days, 14 days and 30 days, and discussed the changes of the modified Rankin scale score (mRS) and National Institutes of Health Stroke Scale (NIHSS) score. Results: At 7 days, 14 days, and 30 days of treatment, the NIHSS score, mRS score, hs-CRP, IL-6, TNF-α, and Hcy levels were statistically significant (P α, and Hcy levels in the treatment group were significantly lower than those in the control group (P Conclusion: Patients with acute cerebral infarction received Huoxue Tongmai capsule combined with edaravone right camphor, which can reduce the inflammatory reaction, improve the nerve function and improve the prognosis. 展开更多
关键词 Acute Cerebral Infarction Huoxue Tongmai Capsule Edaravone Right Camphor Inflammatory Factors Nerve Function
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Efficacy of laparoscopic radical resection of colorectal cancer in older patients and its effects on inflammatory factors 认领 引用 被引量：1
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作者 Zhen-Yu Min Jie Zhou +1 位作者 Zhong-Wei Zhu Zhen-Zhong Fa 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第5期192-199,共8页
AIM To analyze the efficacy of laparoscopic radical resection of CRC(LRRCC)in treating older patients with CRC and the effect of this procedure on inflammatory factors.METHODS The study included 104 older patients wit... AIM To analyze the efficacy of laparoscopic radical resection of CRC(LRRCC)in treating older patients with CRC and the effect of this procedure on inflammatory factors.METHODS The study included 104 older patients with CRC admitted from August 2022 to August 2024.Participants undergoing open radical resection of CRC were categorized as the control group(50 patients),whereas those receiving LRRCC were classified as the research group(54 patients).Subsequently,comparative analyses involved data on efficacy,postoperative complications(ileus,incision infection,anastomotic fistula,and pulmonary infection),surgery-related parameters(operation duration and intraoperative bleeding volume),postoperative recoveryrelated indicators(time to first postoperative passage of flatus and defecation and length of hospital stay),and inflammatory factors(tumor necrosis factor-α,highsensitivity C-reactive protein,and interleukin-6).RESULTS Data revealed markedly superior therapeutic efficacy and a lower overall postoperative complication rate in the research group compared to the control group.The research group demonstrated substantially less intraoperative bleeding,less time to first postoperative passage of flatus and defecation,and a shorter length of hospital stay despite a notably longer operation duration compared to the control group.Further,tumor necrosis factor-α,high-sensitivity C-reactive protein,and interleukin-6 levels in the research group were significantly reduced 3 days postoperatively compared to both the preoperative and control group values.CONCLUSION LRRCC for older patients with CRC exhibited superior therapeutic efficacy compared to open radical resection and significantly suppressed postoperative stress-related inflammatory responses,which merits clinical application and promotion. 展开更多
关键词 Laparoscopy Radical resection of colorectal cancer Colorectal cancer in the elderly Therapeutic effect Inflammatory factor
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Analysis of the Clinical Effect of Pulmicort Respules Inhalation Combined with Cetirizine in the Treatment of Pediatric Asthma and its Influence on Inflammatory Factors in Children 认领 引用 被引量：1
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作者 Yong Peng Aimin Li 《Proceedings of Anticancer Research》 2025年第2期71-76,共6页
Objective:To analyze the clinical value of Pulmicort Respules inhalation combined with cetirizine in the treatment of pediatric asthma.Methods:From December 2023 to December 2024,82 children with asthma admitted to ou... Objective:To analyze the clinical value of Pulmicort Respules inhalation combined with cetirizine in the treatment of pediatric asthma.Methods:From December 2023 to December 2024,82 children with asthma admitted to our hospital were randomly divided into a control group and an observation group,with 41 cases in each group.The clinical symptom relief time(shortness of breath,cough,dyspnea,lung wheezing),lung function indicators(FEV1,FVC,FEV1/FVC),inflammatory indicators(TNF-α,IL-6,IL-8),and clinical treatment effects were analyzed in the two groups.Results:The relief time for shortness of breath,cough,dyspnea,and lung wheezing in the observation group was shorter than that in the control group(P<0.05).After treatment,compared with the control group,the levels of FEV1,FVC,FEV1/FVC,and treatment efficiency in the observation group were higher,while the levels of TNF-α,IL-6,and IL-8 were lower(P<0.05).Conclusion:The combination of Pulmicort Respules inhalation and cetirizine oral therapy for children with asthma can shorten the improvement time of clinical symptoms,inhibit inflammation,and improve lung function. 展开更多
关键词 Pulmicort Respules Cetirizine Pediatric asthma Inflammatory factors
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Effect of totally thoracoscopic esophagectomy on postoperative complications and serum inflammatory factors in patients with early esophageal cancer 认领 引用
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作者 Heng-Chi Zhao Shuang Zhang +4 位作者 Lin Zhou Xiao-Long Lou Dong Chen Cheng-Wei Shi Zhe Ren 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第10期165-173,共9页
BACKGROUND Although thoracotomy has been the conventional treatment for patients with early esophageal cancer(EEC),its drawbacks underscore the demand for more effective therapeutic strategies to improve surgical outc... BACKGROUND Although thoracotomy has been the conventional treatment for patients with early esophageal cancer(EEC),its drawbacks underscore the demand for more effective therapeutic strategies to improve surgical outcomes.AIM To comprehensively analyze the effect of totally thoracoscopic esophagectomy(TTE)on postoperative complications and serum inflammatory factors in patients diagnosed with EEC.METHODS A total of 113 patients with EEC,who were admitted to our hospital between September 2022 and December 2024,were recruited for this study.Specifically,55 patients were assigned to the control group and underwent conventional surgical procedures,whereas 58 patients formed the research group and underwent TTE.Subsequently,a series of comparisons and analyses were conducted between the two groups.These comparisons included surgery-related parameters,such as incision length,operation duration,and the number and extent of lymph node dissection;postoperative complications,namely,empyema,pulmonary infection,incision infection,anastomotic fistula,and delayed gastric emptying;postoperative pain,which was quantitatively evaluated by the Numerical Rating Scale;postoperative hospitalization duration;serum inflammatory factors,including interleukin(IL)-6,IL-8,and tumor necrosis factor-α;and stress response-associated indicators,such as C-reactive protein,cortisol,and adrenaline.RESULTS Statistical data demonstrated that compared with the control group,the research group exhibited substantially shorter incision length and postoperative hospitalization duration.The two groups had comparable number and extent of lymph node dissection.Notably,both the overall incidence of postoperative complications and the Numerical Rating Scale score on postoperative day 3 were remarkably lower in the research group.Although the levels of IL-6,IL-8,tumor necrosis factor-α,C-reactive protein,cortisol,and adrenaline in the research group increased statistically postoperatively,they were still considerably lower than those in the control group.CONCLUSION In patients with EEC,TTE not only reduces the risk of postoperative complications but also effectively alleviates the body’s inflammatory and stress responses associated with surgery. 展开更多
关键词 Totally thoracoscopic esophagectomy Early esophageal cancer Postoperative complications Serum inflammatory factors Inflammation Stress response Clinical outcomes
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Effect of negative mood,serum inflammatory factors,miR-155,and brain-derived neurotrophic factor 认领 引用
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作者 Qi Zhang Yue Zhao Guang-Yu Cheng 《World Journal of Psychiatry》 SCIE 2025年第2期85-91,共7页
BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AI... BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors. 展开更多
关键词 Syndrome differentiation acupuncture Abdominal surgery Depression Negative mood Serum inflammatory factor Tiny RNA-155
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The Impact of Early Initiation of Intensive Lipid-Lowering Therapy on the Efficacy and Inflammatory Factors in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention 认领 引用
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作者 Yue Kan Yongfu Zhao +3 位作者 Hong Gao Shihao Zhao Jiaxu Liu Zhanxiu Zhang 《Journal of Clinical and Nursing Research》 2025年第11期150-157,共8页
Objective:To investigate the impact of early initiation of intensive lipid-lowering therapy on the postoperative efficacy and inflammatory factors in patients with acute coronary syndrome(ACS)undergoing percutaneous c... Objective:To investigate the impact of early initiation of intensive lipid-lowering therapy on the postoperative efficacy and inflammatory factors in patients with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI).Methods:A total of 100 ACS patients undergoing PCI admitted to our hospital were selected as the study subjects.They were randomly divided into a control group(treated with statin combined with ezetimibe,n=41),a study group 1(initiated with statin combined with PCSK9 inhibitor immediately after surgery,n=32),and a study group 2(routinely administered oral statin and initiated with combined PCSK9 inhibitor before discharge,n=27).The therapeutic efficacy,inflammatory factor levels,and incidence of adverse events were compared and analyzed among the three groups.Results:The therapeutic regimen in study group 1 demonstrated the optimal efficacy and impact on inflammatory factors,followed by study group 2,while the control group showed relatively weaker efficacy,with statistically significant differences(p<0.05).The overall incidence of adverse reactions was 30.00%in the control group,5.00%in study group 1,and 10.00%in study group 2,with statistically significant differences among the groups(p<0.05),with the lowest incidence observed in study group 1.Conclusion:Early intensive lipid-lowering therapy can effectively improve lipid metabolism,suppress inflammatory responses,and reduce cardiovascular events in ACS patients after PCI,suggesting its pleiotropic cardiovascular protective effects. 展开更多
关键词 Early Intensive lipid-lowering Acute coronary syndrome PCI patients Efficacy Inflammatory factors
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Effect of Traditional Chinese Medicine combined with Western Medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome:a network Meta-anal 认领 引用 被引量：25
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作者 WANG Chao WU Qiong +4 位作者 LI Ping WANG Zhigang LOU Xusheng LI Yuanyuan ZHANG Lin 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第4期640-649,共10页
OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METH... OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network Meta-analysis.METHODS:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December 2021.Literature was screened and literature bias risk was assessed by RevMan5.4 software.The overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 software.RESULTS:Totally,26 RCTs were included,involving 2098 participants.There were 6 TCM formulas with the effects of dispelling phlegm and removing blood stasis.Taking conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,MXD.The sequence of TC improvement from high to low was MZXGD,MED,DT,and MGXBD.Sequence of improving TG from high to low was MED,MZXGD,MGXBD,and DT.For LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and MED.With regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and DT from good to poor.hs-CRP expression from high to low was MZXGD,MXD,MED,MWD,and MGXBD.CONCLUSION:TCM formula with the effects of dispelling phlegm and removing blood stasis combined with conventional Western Medicine has obvious advantages in treating CHD angina pectoris with interaction of phlegm and blood stasis.MZXGD has great potential in increasing the overall response rate,reducing Duration of angina attack improving blood lipids,and reducing inflammatory factors.However,due to the limitations of extant studies,the conclusions of this study need to be confirmed by numerous reasonably-designed RCTs. 展开更多
关键词 coronary disease angina pectoris phlegm and blood stasis interaction blood lipid inflammatory factors medicine traditional Chinese network Meta-analysis randomized controlled trial
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Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis 认领 引用 被引量：45
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作者 YongMeng Qing-YongMa +1 位作者 Xiao-PingKou JunXu 《World Journal of Gastroenterology》 SCIE CAS 2005年第4期525-528,共4页
AIM: To observe the effect of resveratrol on nuclear factor Kappa-B (NF-κB) activation and the inflammatory response in sodium taurocholate-induced pancreatitis in rats. METHODS: Seventy-two male SD rats were randoml... AIM: To observe the effect of resveratrol on nuclear factor Kappa-B (NF-κB) activation and the inflammatory response in sodium taurocholate-induced pancreatitis in rats. METHODS: Seventy-two male SD rats were randomly divided into three groups: sham operation group (control), severe acute pancreatitis (SAP) group, and severe acute pancreatitis group treated with resveratrol (RES). A SAP model was established by injecting 4% sodium taurocholate 1 mL/kg through puncturing the pancreatic duct. In Res group, Res was given at 30 mg/kg b.m. intraperitoneally after the SAP model was successfully established. Eight animals from each group were sacrificed at 3, 6 and 12 h after modeling. The expression of NF-κB activation of pancreas was detected by irnmunohistochemical staining, whereas the levels of TNF-α and IL-8 in pancreatic tissues were estimated by radioimrnunoassay. The pathological changes of pancreas and lungs were examined microscopically. RESULTS: Much less hyperemia, edema, dust-colored necrotic focus and soaps were noticed in pancreas in RES group than in SAP group. In RES group, hemorrhage, exudates and infiltration of inflammatory cells in pancreas and interstitial edema, destruction of alveolar wall in lung were significantly less than in SAP group. In the SAP group, the activation of NF-κB in pancreatic tissues was enhanced significantly at any measure point compared with control group (64.23±10.72% vs 2.56±0.65%, 55.86±11.34% vs 2.32±0.42%, 36.23±2.30% vs 2.40±0.36%,P<0.01), TNF-α, IL-8 were also increased and reached their peak at 6 h and then declined. The activation of NF-κB and the levels of TNF-α and IL-8 in RES group were significantly lower than those in SAP group (P<0.01): activation (52.63±9.45% vs 64.23±10.72%, 40.52±8.40% vs 55.86±11.34%, 29.83±5.37% vs 36.23±2.30%), TNF-α (132.76±15.68 pg/mL vs 158.36±12.58 pg/mL, 220.32±23.57 pg/mL vs 247.67± 11.62 pg/mL, 175.68±18.43 pg/mL vs 197.35±12.57 pg/mL) and IL-8 (0.62±0.21 μg/L vs 0.83±0.10 μg/L, 1.10±0.124 μg/L vs1.32±0.18 μg/L, 0.98±0.16 μg/L vs 1.27±0.23μg/L). CONCLUSION: The activation of NF-KB is involved in the inflammatory response of rats with SAP. Resveratrol could effectively inhibit the expression of NF-κB activation, alleviate the severity of SAP through its anti-inflammatory effects and regulate the inflammatory mediators. 展开更多
关键词 Acute pancreatitis Resveratrol NF-κB Inflammatory factors
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Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway 认领 引用 被引量：26
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作者 Tao Zhang Jia-Yi Liao +1 位作者 Li Yu Guo-Sheng Liu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2017年第12期1172-1176,共5页
Objective: To study the influence of glycyrrhetinic acid(GA) on bronchial asthma(BA)smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism.Methods: Male SD guin... Objective: To study the influence of glycyrrhetinic acid(GA) on bronchial asthma(BA)smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism.Methods: Male SD guinea pigs were selected and made into asthma models, bronchial asthma smooth muscle cells were cultured and divided into BA group, GA group and GA + LM group that were treated with serum-free RPMI1640 culture medium, serumfree RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid and 100 ng/mL LM22B-10 respectively; normal guinea pigs were collected and bronchial smooth muscle cells were cultured as control group. The cell proliferation activity as well as the expression of proliferation and apoptosis genes, inflammatory factors and p-ERK1/2 was determined.Results: Proliferation activity value and m RNA expression of Bcl-2, TNF-α, IL-4, IL-6,YKL-40, protein expression of p-ERK1/2 of airway smooth muscle cell in BA group were significantly higher than those of control group while m RNA expression levels of Bax,caspase-9 as well as caspase-3 were significantly lower than that of control group(P < 0.05); proliferation activity value and m RNA expression of Bcl-2, TNF-α, IL-4, IL-6, YKL-40, protein expression of p-ERK1/2 of airway smooth muscle cell in GA group were significantly lower than those of BA group(P < 0.05) while the m RNA expression levels of Bax, caspase-9 as well as caspase-3 were significantly higher than those of BA group(P < 0.05); proliferation activity value and m RNA expression of Bcl-2, TNF-α, IL-4, IL-6, YKL-40 of airway smooth muscle cell in GA + LM group were significantly higher than those of GA group(P < 0.05) while m RNA expression levels of Bax, caspase-9 as well as caspase-3 were significantly lower that of GA group(P < 0.05).Conclusion: GA can inhibit the proliferation of bronchial smooth muscle cells and reduce the expression of inflammatory factors by inhibiting the phosphorylation of ERK1/2. 展开更多
关键词 Bronchial asthma Glycyrrhetinic acid Extracellular signal-regulated kinase 1/2 Apoptosis Inflammatory factors
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Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells 认领 引用 被引量：7
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作者 Hang Li Xiao-Qing Ji +1 位作者 Shu-Ming Zhang Ri-Hui Bi 《World Journal of Stem Cells》 SCIE 2023年第11期999-1016,共18页
BACKGROUND Mesenchymal stem cells(MSCs)have great potential for the treatment of various immune diseases due to their unique immunomodulatory properties.However,MSCs exposed to the harsh inflammatory environment of da... BACKGROUND Mesenchymal stem cells(MSCs)have great potential for the treatment of various immune diseases due to their unique immunomodulatory properties.However,MSCs exposed to the harsh inflammatory environment of damaged tissue after intravenous transplantation cannot exert their biological effects,and therefore,their therapeutic efficacy is reduced.In this challenging context,an in vitro preconditioning method is necessary for the development of MSC-based therapies with increased immunomodulatory capacity and transplantation efficacy.AIM To determine whether hypoxia and inflammatory factor preconditioning increases the immunosuppressive properties of MSCs without affecting their biological characteristics.METHODS Umbilical cord MSCs(UC-MSCs)were pretreated with hypoxia(2%O2)exposure and inflammatory factors(interleukin-1β,tumor necrosis factor-α,interferon-γ)for 24 h.Flow cytometry,polymerase chain reaction,enzyme-linked immunosorbent assay and other experimental methods were used to evaluate the biological characteristics of pretreated UC-MSCs and to determine whether pretreatment affected the immunosuppressive ability of UC-MSCs in coculture with immune cells.RESULTS Pretreatment with hypoxia and inflammatory factors caused UC-MSCs to be elongated but did not affect their viability,proliferation or size.In addition,pretreatment significantly decreased the expression of coagulationrelated tissue factors but did not affect the expression of other surface markers.Similarly,mitochondrial function and integrity were retained.Although pretreatment promoted UC-MSC apoptosis and senescence,it increased the expression of genes and proteins related to immune regulation.Pretreatment increased peripheral blood mononuclear cell and natural killer(NK)cell proliferation rates and inhibited NK cell-induced toxicity to varying degrees.CONCLUSION In summary,hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their biological characteristics. 展开更多
关键词 Mesenchymal stem cells Umbilical cord Preconditioning Hypoxia,Inflammatory factors Immune regulation
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Low-dose dopamine reduces inflammatory factors of acute pancreatitis in rats 认领 引用 被引量：3
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作者 Zhang, Shun Peng, Xin-Gang +2 位作者 Liu, Chang-Chang Liu, Hong Lu, Yun 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2007年第6期646-649,共4页
BACKGROUND: Acute pancreatitis, especially acute necrotizing pancreatitis (ANP), is a serious disease with a high morbidity because of multiorgan dysfunction. Recent studies have indicated that during the pathogenesis... BACKGROUND: Acute pancreatitis, especially acute necrotizing pancreatitis (ANP), is a serious disease with a high morbidity because of multiorgan dysfunction. Recent studies have indicated that during the pathogenesis of ANP, changes of the microcirculation play an important role in the worsening of the disease. This study based on a. model of acute pancreatitis in Wistar rats was to determine the effect of treatment with low-dose dopamine on acute pancreatitis by the dynamic measurement of serum levels of inflammatory factors IL-6 and TNF-alpha. METHODS: Fifty Wistar rats were randomly divided into two groups, and a model of ANP was set up by injecting sodium taurocholate into the pancreatic duct. Rats in the dopamine group (treatment group) were given dopamine by vein and those in the acute pancreatitis group (control group) were given normal saline. To assess the effect of low-dose doparnine (5 mu g . kg(-1) . min(-1)) on induced acute pancreatitis, the antibody sandwich ELISA method was used to measure the serum levels of IL-6 and TNF-alpha at different times before and after the induction of ANP. RESULTS: The serum levels of IL-6 and TNF-alpha in the treatment and control groups before and after ANP induction were significantly different. There was a markedly significant difference in the comparison of the two groups after ANP induction (P0.05). Postoperative pancreatic histopathologic changes in the treatment group were more marked than those in the control group. CONCLUSIONS: Low-dose dopamine is effective in treating ANP by alleviating inflammatory reactions. This effect may be related to the fact that low-dose doparnine not only can increase the blood flow of the pancreatic microcirculation but also reduce its permeability. 展开更多
关键词 acute pancreatitis dopamine inflammatory factor
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Effects of linagliptin on inflammatory factors and arteriosclerosis in patients with newly diagnosed type 2 diabetes mellitus 认领 引用 被引量：4
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作者 Rui Li Yanru Kong 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2021年第8期692-698,共7页
In the present study,we aimed to investigate the effects of linagliptin on inflammatory factors and carotid intima-media thickness(CIMT)in newly diagnosed type 2 diabetes mellitus(T2 DM)patients with carotid atheroscl... In the present study,we aimed to investigate the effects of linagliptin on inflammatory factors and carotid intima-media thickness(CIMT)in newly diagnosed type 2 diabetes mellitus(T2 DM)patients with carotid atherosclerotic disease(CAD).A total of 326 patients with newly diagnosed T2 DM complicated with CAD were randomly divided into two groups.There were 163 patients in the control group,who were treated with metformin monotherapy.There were 163 patients in the experimental group,who were treated with metformin in combination with linagliptin.The CIMT before and after treatment was measured by color Doppler ultrasound,and the contents of IL-6 and IL-1βbefore and after treatment were detected by ELISA.The levels of inflammatory factors and CIMT before and after treatment were compared between the two groups,and the correlation between IL-6,IL-1βand CIMT was studied.After 24 weeks of treatment,the levels of inflammatory factors and CIMT in the experimental group were significantly lower compared with the control group(P<0.01),and the serum levels of IL-6 and IL-1βwere positively correlated with CIMT.In the present study,we concluded that linagliptin could improve the levels of inflammatory factors and CIMT in newly diagnosed T2 DM patients with CAD,and IL-6 and IL-1βmight participate in the occurrence and development of CAD by influencing CIMT. 展开更多
关键词 Linagliptin Type 2 diabetes mellitus Carotid atherosclerosis disease Inflammatory factors Carotid intima-media thickness
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Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma 认领 引用 被引量：1
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作者 Peng Cao Zhe-Yong Jia +1 位作者 Tao Zheng Tao Mei 《World Journal of Psychiatry》 SCIE 2024年第7期1043-1052,共10页
BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health problem.Some patients with TBI have poor trea... BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health problem.Some patients with TBI have poor treatment outcomes and are prone to postoperative delirium(POD),which affects their quality of life.Anxiety has been linked to increased POD incidence in some studies,while others have found no correlation.AIM To investigate the correlation of POD risk factors,preoperative inflammatory factors,and mood disorders in patients with TBI.METHODS We retrospectively collected data on the treatment of 80 patients with TBI from November 2021 to September 2023.Patients were grouped as POD and non-POD,according to their POD status,and the general data of the two groups were compared.Inflammatory factor levels were detected preoperatively,and the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to investigate the risk factors associated with POD in these patients.Logistic regression was used to identify the independent risk factors.RESULTS Twenty-one patients(26.25%)developed POD,including 7,10,and 4 cases of the excitatory,inhibitory,and mixed types,respectively.There were 59 cases(73.75%)in the non-POD group.Compared with the non-POD group,the POD group had a significantly higher proportion of patients with low Glasgow Coma Scale(GCS)scores before admission,unilateral mydriasis,preoperative hemorrhagic shock,intraventricular hemorrhage(IVH),and postoperative hyperglycemic hyperosmolar disease(P<0.05).In the POD group,interleukin-6(IL-6),human tumor necrosis factor-α(TNF-α),myeloperoxidase levels,HAMA,and HAMD scores were higher than those in the non-POD group(all P<0.05).Logistic multivariate analysis showed that GCS score at admission,IVH,IL-6,TNF-α,HAMA,and HAMD were independent risk factors for POD in patients with TBI(P<0.05).CONCLUSION Low GCS score at admission,IVH,elevated IL-6 and TNF-α,other inflammatory indicators,anxiety,and depression,can increase the risk of POD in patients with TBI after surgery. 展开更多
关键词 Inflammatory factors Mood disorders Traumatic brain injury Postoperative delirium Relevance Risk factor
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