Intent-Based Networks(IBNs),which are originally proposed to introduce Artificial Intelligence(AI)into the sixth-generation(6G)wireless networks,can effectively solve the challenges of traditional networks in terms of...Intent-Based Networks(IBNs),which are originally proposed to introduce Artificial Intelligence(AI)into the sixth-generation(6G)wireless networks,can effectively solve the challenges of traditional networks in terms of efficiency,flexibility,and security.IBNs are mainly used to transform users’business intent into network configuration,operation,and maintenance strategies,which are prominent for designing the AI-enabled 6G networks.In particular,in order to meet the massive,intelligent service demands and overcome the time-varying radio propagation,IBNs can continuously learn and adapt to the time-varying network environment based on the massive collected network data in real-time.From the aspects of both the core network and radio access network,this article comprehensively surveys the architectures and key techniques of IBNs for 6G.In particular,the demonstration platforms of IBNs,such as the Apstra Operating System,Forward Networks Verification Platform,and One Convergence Service Interaction Platform,are presented.Moreover,the industrial development of IBNs is elaborated,including the emerging new products and startups to solve the problems of open data platforms,automated network operations,and preemptive network fault diagnosis.Finally,several open issues and challenges are identified as well to spur future researches.展开更多
Paints with passive daytime radiative cooling capability hold significant promise for energy-efficient buildings owing to their ease of processing.However,conventional radiative cooling paints require substantial thic...Paints with passive daytime radiative cooling capability hold significant promise for energy-efficient buildings owing to their ease of processing.However,conventional radiative cooling paints require substantial thickness to achieve effective outdoor cooling and must be combined with binders to enhance adhesion to the substrate.Meanwhile,their long-term outdoor durability remains poor.In this work,we proposed a scattering network-enhanced ultrathin photonic cooling paint(thickness of 78μm)fabricated without traditional binders through a universal,scalable solution-assembly strategy under a low-carbon production process.Cellulose nanofiber and cellulose nanocrystal were employed to wrap and entangle TiO2,forming a topological scattering network that prevents near-field coupling.Together with hierarchical pores,this structure enables high solar reflectance(96.4%)and an infrared emissivity of 0.94.This novel paint achieves temperature reduction of~5.6 and 3.8℃ under low and high-humidity conditions of midday,respectively,while maintaining long-term outdoor stability.Importantly,the cellulose-weaved topological scattering network can also be engineered with alternative photonic cooling pigments(Al2O3,SiO2,BaSO4,and mica),demonstrating its universality.In addition,life cycle assessment reveals that the obtained cooling paint offers very low carbon emissions and minimal environmental impacts.This work provides an economically viable and environmentally sustainable alternative to existing passive cooling materials.展开更多
Increased crop diversity can alter soil nitrogen(N)levels,soil properties,and functional microbial communities,leading to changes in potential nitrous oxide(N2O)emissions.However,our understanding on relationships ...Increased crop diversity can alter soil nitrogen(N)levels,soil properties,and functional microbial communities,leading to changes in potential nitrous oxide(N2O)emissions.However,our understanding on relationships between N2O emissions and related microbes in diversified rotation systems is still limited.Here,we established a long-term field experiment to investigate the response of N2O emissions regulated by five N-cycling genes in three rotation systems.Our results showed that N2O emissions in wheat and maize seasons in diversified rotations(spring maize→winter wheat–summer maize and spring peanut→winter wheat–summer maize)were 15.5%-51.1%and 15.9%-53.3%lower than that in winter wheat–summer maize rotation(P<0.05),respectively.Diversified rotations decreased abundance of ammonia-oxidizing archaea(AOA)amoA,AOB amoA,nirK and nirS genes in both wheat and maize seasons,while increased abundance of nosZ gene in maize season,leading to lower soil N2O emissions.Changes in these functional genes correlated significantly with soil moisture,nitrogen availability,and enzyme activity(L-leucine aminopeptidase and Urease).Besides,diversified rotations increased number of nodes,edges and degree of the co-occurring network and sub-network,while reduced average path length and betweeness.These microbial co-occurrence network complexity indicators were significantly correlated with N2O emissions.This indicates that increase in aboveground crop diversity drives the increase in complexity of belowground N-cycling related microbial interaction networks,which leads to lower N2O emissions.In summary,diversified rotations show promising potentials to lower N2O emissions in agricultural soils.展开更多
While the complexity of fifth-generation wireless networks is being widely commented upon,there is great anticipation for the arrival of the sixth generation(6G),with its enriched capabilities and features.It can easi...While the complexity of fifth-generation wireless networks is being widely commented upon,there is great anticipation for the arrival of the sixth generation(6G),with its enriched capabilities and features.It can easily be imagined that,without proper design,the enrichment of 6G will further increase system complexity.To address this issue,we propose the Agentic-AI Core(A-Core),an artificial intelligence(AI)-empowered,mission-oriented core network architecture for next-generation mobile telecommunications.In A-Core,network capabilities can be added and updated on the fly and further programmed into missions for enabling and offering diverse services to customers.These missions are created and executed by autonomous network agents according to the customer's intent,which may be expressed in natural language.The agents resolve intents from customers into workflows of network capabilities by leveraging a large-scale network AI model and follow the workflows to execute the mission.As an open,agile system architecture,A-Core holds promise for accelerating innovation and greatly reducing standard release times.The advantages of A-Core are demonstrated through two use cases.展开更多
In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This s...In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This study aims to explore the complex evolution of the space debris environment and assess the collision risks associated with spacecraft.First,a space debris environment topological network model is proposed,which incorporates interdisciplinary methods from topological networks,fluid mechanics,and spacecraft dynamics.This model enables a structured representation of the relationships among space objects and provides rapid predictions of the space debris environment.Then,a collision probability algorithm based on the topological network model is introduced.This algorithm inherits the efficiency advantages of the topological network model and has been validated for reliability through comparison with the classical ESA’s DRAMA software.Finally,based on the above models,the collision risks of constellation satellites in Low Earth Orbit(LEO)are analyzed,including both operational and deorbit processes.The study reveals that constellation satellites face a much higher risk of internal collisions with satellites from the same constellation during operations than that with other space objects.Additionally,during the satellite deorbit process,the collision risk peaks when satellites traverse the operational region of Starlink satellites.展开更多
This comprehensive survey paper examines the applications of Artificial Intelligence(AI)in Unmanned Aerial Vehicle(UAV)-enabled wireless networks.With the increasing demand for efficient and adaptive communication sys...This comprehensive survey paper examines the applications of Artificial Intelligence(AI)in Unmanned Aerial Vehicle(UAV)-enabled wireless networks.With the increasing demand for efficient and adaptive communication systems,the integration of AI with UAV networks promises to revolutionize various aspects of wireless communication.The paper first outlines the background and motivation behind AI integration,highlighting the potential for enhanced network performance,autonomy,and adaptability.It then delves into the key AI applications across different network layers,including data sensing and collection,placement and trajectory optimization,radio resource management,routing and topology control,edge computing and caching,as well as security and privacy enhancement.For each application,the paper discusses relevant AI techniques,main findings,optimization objects,and the potential benefits and challenges.The survey also identifies open issues,such as the practical implementation gap,standardization issues,and real-world application barriers,and proposes future directions to address these challenges and further advance the field.In conclusion,the integration of AI with UAV-enabled Wireless Networks(UWNs)holds tremendous potential for transforming wireless communication,enabling new applications and services with unprecedented capabilities.展开更多
Internal structural defects in engineering rock masses vary in size,exhibit complex shapes,and are unevenly distributed.Dominant fractures within a rock mass often play a critical to its mechanical behavior,directly a...Internal structural defects in engineering rock masses vary in size,exhibit complex shapes,and are unevenly distributed.Dominant fractures within a rock mass often play a critical to its mechanical behavior,directly affecting the macromechanical properties and failure modes.These fractures affect the instability and failure of the surrounding rock,significantlyimpacting the overall stability of engineering structures.Herein,sand-powder three-dimensional(3D)printing technology was used to prepare rock-like specimens with internal fracture networks.Triaxial compression testing,post-failure fracture mapping,and fractal dimension analysis of the fracture surfaces were conducted to investigate the effects of dominant fracture angles on the strength and deformation of rocks with internal fracture networks under triaxial stress.The results indicate that the dominant fracture angle has a pronounced effect on the mechanical behavior of rock.With increasing angle,both compressive strength and elastic modulus exhibit an initial decline followed by an increase.Moreover,higher confiningpressure significantlyimproves the compressive strength of fractured rock.This enhancement weakens as the confiningpressure further increases.Moreover,with increasing confiningpressure,the differences between the maximum and minimum values of elastic moduli and lateral strain ratios in fractured rock gradually decrease.Thus,the impact of the dominant fracture angle on rock mass deformation decreases with increasing confiningpressure.This research elucidates the effects of dominant fracture angles on the mechanical and failure properties of complex fractured rock masses and the influenceof the confiningpressure on these relationships.It provides valuable theoretical insights and practical guidance for stability analyses in engineering rock masses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the reg...Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established.展开更多
Sedimentary facies modeling is a critical approach for understanding geological phenomena,yet the strong heterogeneity of reservoir systems poses a serious challenge for their refined characterization.In this study,we...Sedimentary facies modeling is a critical approach for understanding geological phenomena,yet the strong heterogeneity of reservoir systems poses a serious challenge for their refined characterization.In this study,we innovatively propose an interpretable attention-guided generative adversarial network framework with dual-domain learning,which achieves precise sedimentary facies modeling under the constraints of well facies and soft probability data.Specifically,we first effectively extract and preserve prior information of sedimentary facies models from both spatial and frequency domain perspectives.Then,during simulation,to enhance the capability of the network model for finely characterizing complex heterogeneous models,cross-spatial attention mechanisms are designed to effectively capture short-range and long-range dependencies between multi-scale pattern features.Additionally,through systematic feature map visualization analysis,we elucidate the processes of conditional fitting and complex sedimentary facies model reconstruction,intuitively demonstrating the functional mechanisms of each module.Finally,systematic experiments are conducted on multiple datasets to validate the effectiveness of the proposed method.The results demonstrate that the generated sedimentary facies models exhibit high consistency with training datasets in terms of visual realism and statistical indicators.Quantitative comparisons reveal remarkable performance of the method,achieving low Wasserstein distance(0.09),Kernel Inception Distance(0.0017)and Kernel Maximum Mean Discrepancy(0.21).These findings further confirm the high realism of the generated realizations regarding pattern features.This study offers a reliable and practical method for geological reservoir modeling,thereby advancing quantitative,precise geological research with broad application prospects.展开更多
Urban spatial morphology(USM)optimization is critical to balancing biodiversity conservation and sustainable urbanization.However,previous studies predominantly focused on the socio-economic efficiency and static ecol...Urban spatial morphology(USM)optimization is critical to balancing biodiversity conservation and sustainable urbanization.However,previous studies predominantly focused on the socio-economic efficiency and static ecological metrics and rarely addressed the dynamic USM optimization across spatial scales.Here,we developed a multi-level ecological network(MEN)framework to resolve the tension between urban expansion and ecological integrity.By integrating the cost-weighted distance analysis with a hierarchical network transmission mechanism,we established a cross-scale spatial optimization system,which coordinated the regional ecological corridors and local habitat patches.Comparative experiments with conventional single-scale approaches and scenario simulations using the PLUS model show that the MEN framework had superior performance in three dimensions:(1)spatial governance:the primary-level network(peri-urban natural reserves)effectively contained urban sprawl,and the secondary-level network(intra-urban green corridors)mitigated habitat fragmentation and improved the built-environment;(2)scenario robustness:the model maintained an optimal compactness-loose balance in multiple development pathways;(3)landscape metrics:patch fragmentation decreased by 18.25%,and the internal landscape richness improved by 10.66%compared to the scenario without USM optimization.The findings provide new insight to establish a hierarchical ecological optimization framework as a nature-based spatial protocol to reconcile metropolitan growth with landscape sustainability.展开更多
Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability...Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability of the triazine ring structure within cyanate ester(CE)crosslinked networks after molding posed significant challenges for both recycling,repairing,and degradation of resin.To address these obstacles,dynamic thiocyanate ester(TCE)bonds and photocurable group were incorporated into CE,obtaining the recyclable and 3D printable CE covalent adaptable networks(CANs),denoted as PTCE1.5.This material exhibits a Young's modulus of 810 MPa and a tensile strength of 50.8 MPa.Notably,damaged printed PTCE1.5 objects can be readily repaired through reprinting and interface rejoining by thermal treatment.Leveraging the solid-state plasticity,PTCE1.5 also demonstrated attractive shape memory ability and permanent shape reconfigurability,enabling its reconfigurable 4D printing.The printed PTCE1.5 hinges and a main body were assembled into a deployable and retractable satellite model,validating its potential application as a controllable component in the aerospace field.Moreover,printed PTCE1.5 can be fully degraded into thiol-modified intermediate products.Overall,this material not only enriches the application range of CE resin,but also provides a reliable approach to addressing environmental issue.展开更多
Urbanization is a significant driver of the loss of biodiversity and the disruption of ecosystems.Amphibians are especially vulnerable to the negative impact of urbanization as their life cycles and habitat requiremen...Urbanization is a significant driver of the loss of biodiversity and the disruption of ecosystems.Amphibians are especially vulnerable to the negative impact of urbanization as their life cycles and habitat requirements are complex.The present study investigated the effects of urbanization on amphibian predation networks in suburban Kunming in Yunnan,China and aimed to understand how predation network structure and stability vary with urbanization level.We constructed predation networks by analyzing the stomach contents of amphibians from 12d istinct urbanization gradients.We used the bipartite package in R to evaluate network robustness metrics such as modularity,nestedness,connectivity,and average shortest path length(ASPL).We found that urbanization level is negatively correlated with predation network connectivity(R=−0.67,Ρ=0.02),but there were no significant correlations between urbanization level and nestedness,modularity,or ASPL.Removal of the keystone species destabilized the predation networks at certain locations.The present work highlighted that maintaining prey quantity and diversity preserves predation network connectivity and stabilizes the overall network in urbanizing landscapes.It also underscored the critical role that keystone species play in sustaining network robustness.The results of this research provided insights into the ecological consequences of urbanization.They also suggested that conservation measures should protect the key species and habitats of amphibian predation networks and mitigate the negative impact of urban development on them.展开更多
Networked predictive control(NPC) has gained significant attention in recent years for its ability to effectively and actively address communication constraints in networked control systems(NCSs),such as network-induc...Networked predictive control(NPC) has gained significant attention in recent years for its ability to effectively and actively address communication constraints in networked control systems(NCSs),such as network-induced delays,packet dropouts,and packet disorders.Despite significant advancements,the increasing complexity and dynamism of network environments,along with the growing complexity of systems,pose new challenges for NPC.These challenges include difficulties in system modeling,cyber attacks,component faults,limited network bandwidth,and the necessity for distributed collaboration.This survey aims to provide a comprehensive review of NPC strategies.It begins with a summary of the primary challenges faced by NCSs,followed by an introduction to the control structure and core concepts of NPC.The survey then discusses several typical NPC schemes and examines their extensions in the areas of secure control,fault-tolerant control,distributed coordinated control,and event-triggered control.Moreover,it reviews notable works that have implemented these schemes.Finally,the survey concludes by exploring typical applications of NPC schemes and highlighting several challenging issues that could guide future research efforts.展开更多
Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricu...Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricultural ecosystems.In this study,an 18-year-old alfalfa cultivation area within the saline-alkali Songnen Plain in Northeast China was selected to determine the contribution of the microbial network to the improvement of saline-alkali soils after alfalfa cropping.Our findings indicated that the multi-kingdom microbial network,comprising fungi,bacteria,and archaea,was more complex and stable than the single-kingdom networks.Specifically,the multi-kingdom network exhibited an increased number of nodes and connections,demonstrating higher complexity.By cultivating alfalfa in saline-alkali soils,fungal nodes in the multi-kingdom network demonstrated significantly higher degree and betweenness compared to bacterial nodes and archaeal nodes.Additionally,fungi had a higher natural connectivity,which contributed to the overall network stability.In contrast,the bacterial subset in the multi-kingdom network in bare land exhibited a higher degree,betweenness,and natural connectivity.Furthermore,changes in the topological properties of the microbial network,including its complexity and stability,were significantly correlated with environmental factors,such as soil electrical conductivity and pH.In conclusion,cultivating alfalfa stabilized the self-organization in the multi-kingdom network in saline-alkaline soils and increased the complexity and stability of the fungal network.These findings provide a foundation for further research into the role of multi-kingdom microbial communities in soil ecosystems.展开更多
Microseismic monitoring and signal recognition constitute critical technologies for accurately assessing rockburst risks and ensuring the safe construction of underground rock engineering.This study developed a"S...Microseismic monitoring and signal recognition constitute critical technologies for accurately assessing rockburst risks and ensuring the safe construction of underground rock engineering.This study developed a"Surface+Underground"microseismic intelligent monitoring system to evaluate dynamic disaster risks during construction at the Beishan High-level Radioactive Waste Geological Disposal Laboratory in China.The datasets of four typical one-dimensional time-domain microseismic signals,including rock fracture,blasting,TBM tunneling,and drilling,were constructed,and the BO-CNN-LSTM model is developed to identify and classify these signals..Based on the classification results,the typical time-frequency domain characteristics of the four types of signals are analyzed.The classification results of BO-CNN-LSTM,CNN,LSTM and CNN-LSTM models show that the recognition accuracy of the four models is 98.0%,85.7%,66.7%and 91.0%,respectively.Among all types,the four models demonstrate the highest effectiveness in identifying rock fracture and borehole signals.The findings further confirm that the BO-CNN-LSTM model efficiently recognizes and extracts microseismic signal features,demonstrating superior performance and stability in the classification task.Finally,the study suggests several future research directions,particularly in the areas of raw signal denoising,and automation of feature extraction.展开更多
Dear Editor,This letter presents a novel graph neural network, namely modularized graph convolution network(MGCN), to address the underexplored issue in graph convolution networks(GCNs), wherein the weights for neighb...Dear Editor,This letter presents a novel graph neural network, namely modularized graph convolution network(MGCN), to address the underexplored issue in graph convolution networks(GCNs), wherein the weights for neighbor aggregation are fixed, leading to the limited capability of capturing diverse relationships among nodes for representation learning. Conventional GCNs always learn node representations in the graph according to the weights computed from the graph Laplacian, consequently overlooking the similarity and group cohesiveness of node features.展开更多
Covalent adaptable networks(CANs)have emerged as versatile platforms for sustainable polymer materials,where precise control over the dissociation/exchange kinetics of dynamic covalent bonds is essential for tuning th...Covalent adaptable networks(CANs)have emerged as versatile platforms for sustainable polymer materials,where precise control over the dissociation/exchange kinetics of dynamic covalent bonds is essential for tuning their viscoelastic behaviors.Herein,we introduce a topology-preserving strategy to accelerate network relaxation by embedding slidable mechanically interlocked cross-links into vinylogous urethane-based CANs,yielding mechanically interlocked vitrimers(MIVs).The mechanically bonded junctions are constructed by incorporating kinetically stable acetoacetate-functionalized[2]pseudorotaxane cross-linkers through catalyst-free polymerization with diamines.Although exhibiting higher glass-transition temperatures than a control network with identical cross-linking density but fixed cross-links,the representative MIV-2 maintains comparable ductility while displaying greater toughness,indicating that the slidable cross-links effectively enhance chain sliding.At elevated temperatures,this chain sliding prominently accelerates stress relaxation in MIV-2,showing a substantial reduction in the apparent activation energy for vinylogous urethane exchange compared with the control(10.3 versus 21.2 kJ/mol).Unlike the control with fixed crosslinks,the chain motion enabled by mechanical bonds enhances the diffusion of dynamic covalent moieties,thereby effectively promoting bond exchange throughout the network.Owing to the associative nature of vinylogous urethane exchange,the mechanically bonded cross-links remain topologically constrained on the polymer chains during relaxation.Consequently,the accelerated stress relaxation originates from mechanical-bond-mediated chain sliding rather than defect generation,clearly distinguishing MIVs from defect-mediated dual-dynamic CANs designs commonly employed to promote relaxation.These results disclose how the mechanically interlocked structures regulate chemical reactions in cross-linked polymer networks,establishing a novel strategy of topology-engineering guided structural design for smart multidynamic polymers.展开更多
Objective To address the challenges of systematically identifying herb pairs in traditional Chinese medicine(TCM),we proposed HerbGL,a framework for predicting potential herb pairs that integrates network propagation ...Objective To address the challenges of systematically identifying herb pairs in traditional Chinese medicine(TCM),we proposed HerbGL,a framework for predicting potential herb pairs that integrates network propagation and graph regularization.Methods Based on the assumption that herbal actions induce subtle perturbations in biological systems,a framework named HerbGL was proposed.Random walk with restart(RWR)was first applied to the protein-protein interaction(PPI)network to reconstruct herb-specific perturbation effects and generate weighted subnetworks.Then,to quantify affinity between herb pairs,two network-proximity metrics,Closeness and PageRank,were computed from the weighted subnetworks to construct herb-pair affinity matrices.Finally,these matrices,together with known herb pairs(derived from co-occurrence analysis of TCM formulas with a threshold determined from the inflection point of the frequency distribution),were incorporated into a graph regularization model to predict potential herb pairs.Model performance was assessed through baseline comparison,ablation and robustness experiment under different ratios of positive and negative samples,using the area under the receiver operating characteristic curve(AUROC),the area under the precision-recall curve(AUPRC),accuracy,and precision as evaluation metrics.Furthermore,the predicted herb pairs were validated through both literature evidence and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.Results The weighted subnetworks constructed by RWR provided a refined simulation of herb-specific perturbation effects,which formed the basis for subsequent affinity modeling and prediction.Analysis of herb pair co-occurrence frequencies revealed a marked change around 150,which was selected as the threshold to distinguish herb pairs from non-herb pairs.HerbGL exhibited superior predictive performance compared with baseline models(AUROC=0.9705,AUPRC=0.9555,accuracy=0.7266,precision=0.9706).Ablation results showed that removing the Closeness and PageRank metrics substantially degraded performance(AUROC=0.8191,AUPRC=0.8768),confirming their necessity.Robustness evaluation under an imbalanced positive-to-negative sample ratio of 1:5 yielded AUROC=0.9696 and AUPRC=0.8404,indicating stable predictive ability.Moreover,multiple case studies further validated the rationality of the predicted herb pairs,such as Fangfeng(Saposhnikoviae Radix)and Qingpi(Citri Reticulatae Pericarpium Viride)which are recorded in Liangpeng Huiji(《良朋汇集》,Collection of Excellent Recipes)Vol.3:Fangfeng Shengma Tang(防风升麻汤).Additionally,pathway enrichment analysis of the Renshen(Ginseng Radix et Rhizoma)and Lianqiao(Forsythiae Fructus)pair further supported the biological plausibility of their compatibility.Conclusion HerbGL offers an effective and biologically informed framework for identifying herb pairs in TCM.Beyond improving herb pair prediction,the framework also provides data support for research on herb compounds and mechanisms,thereby supporting data-driven exploration of TCM compatibility.展开更多
In structural optimization,data-driven surrogate models are often explored as alternatives to finite element analysis to reduce computational cost.However,conventional neural networks usually fail to capture key struc...In structural optimization,data-driven surrogate models are often explored as alternatives to finite element analysis to reduce computational cost.However,conventional neural networks usually fail to capture key structural characteristics and are limited to predicting global responses(e.g.,top displacement),but usually fail to achieve accurate internal force predictions with conventional training data volumes.As a result,most existing studies involving surrogate models did not concern internal force constraints.To address this issue,this study proposes a structural optimization framework based on a pre-trained Physics-Informed Neural Network(PINN)surrogate model.By embedding static equilibrium equation into the loss function,the model achieves higher predictive accuracy,particularly for internal forces,while pre-training accelerates convergence and enhances stability.Combined with an improved multi-swarm particle swarm optimization(MPSO)algorithm,the framework enables efficient optimization of multi-story frame structures under internal force and multiple other constraints.The application to a six-story frame structure validates its effectiveness:compared with a DNN-based model,the PINN-based model improves the coefficient of determination for internal force prediction from 0.8874 to 0.9937.These results demonstrate that the proposed method offers a promising approach for efficient optimization of multi-story frame structures.展开更多
基金This work was supported in part by the State Major Science and Technology Special Project(Grant No.2018ZX03001002-004 and 2018ZX03001023)the National Natural Science Foundation of China under No.61921003,61925101,61831002,and 61901044+1 种基金the Beijing Natural Science Foundation under No.JQ18016and the National Program for Special Support of Eminent Professionals.
摘要Intent-Based Networks(IBNs),which are originally proposed to introduce Artificial Intelligence(AI)into the sixth-generation(6G)wireless networks,can effectively solve the challenges of traditional networks in terms of efficiency,flexibility,and security.IBNs are mainly used to transform users’business intent into network configuration,operation,and maintenance strategies,which are prominent for designing the AI-enabled 6G networks.In particular,in order to meet the massive,intelligent service demands and overcome the time-varying radio propagation,IBNs can continuously learn and adapt to the time-varying network environment based on the massive collected network data in real-time.From the aspects of both the core network and radio access network,this article comprehensively surveys the architectures and key techniques of IBNs for 6G.In particular,the demonstration platforms of IBNs,such as the Apstra Operating System,Forward Networks Verification Platform,and One Convergence Service Interaction Platform,are presented.Moreover,the industrial development of IBNs is elaborated,including the emerging new products and startups to solve the problems of open data platforms,automated network operations,and preemptive network fault diagnosis.Finally,several open issues and challenges are identified as well to spur future researches.
基金Dongguan University of Technology Top Talent Professor Start-Up Fund(221110133)(Jonathan W.C.Wong)Start-Up Funds for Scientific Research at Nanjing Forestry University(C.C.)Natural Science Foundation of Jiangsu Province(BK20230404)(C.C.)。
摘要Paints with passive daytime radiative cooling capability hold significant promise for energy-efficient buildings owing to their ease of processing.However,conventional radiative cooling paints require substantial thickness to achieve effective outdoor cooling and must be combined with binders to enhance adhesion to the substrate.Meanwhile,their long-term outdoor durability remains poor.In this work,we proposed a scattering network-enhanced ultrathin photonic cooling paint(thickness of 78μm)fabricated without traditional binders through a universal,scalable solution-assembly strategy under a low-carbon production process.Cellulose nanofiber and cellulose nanocrystal were employed to wrap and entangle TiO2,forming a topological scattering network that prevents near-field coupling.Together with hierarchical pores,this structure enables high solar reflectance(96.4%)and an infrared emissivity of 0.94.This novel paint achieves temperature reduction of~5.6 and 3.8℃ under low and high-humidity conditions of midday,respectively,while maintaining long-term outdoor stability.Importantly,the cellulose-weaved topological scattering network can also be engineered with alternative photonic cooling pigments(Al2O3,SiO2,BaSO4,and mica),demonstrating its universality.In addition,life cycle assessment reveals that the obtained cooling paint offers very low carbon emissions and minimal environmental impacts.This work provides an economically viable and environmentally sustainable alternative to existing passive cooling materials.
基金supported by the National Key Research and Development Program of China(No.2022YFD2300803)the National Natural Science Foundation of China(Nos.32172125 and 31901470).
摘要Increased crop diversity can alter soil nitrogen(N)levels,soil properties,and functional microbial communities,leading to changes in potential nitrous oxide(N2O)emissions.However,our understanding on relationships between N2O emissions and related microbes in diversified rotation systems is still limited.Here,we established a long-term field experiment to investigate the response of N2O emissions regulated by five N-cycling genes in three rotation systems.Our results showed that N2O emissions in wheat and maize seasons in diversified rotations(spring maize→winter wheat–summer maize and spring peanut→winter wheat–summer maize)were 15.5%-51.1%and 15.9%-53.3%lower than that in winter wheat–summer maize rotation(P<0.05),respectively.Diversified rotations decreased abundance of ammonia-oxidizing archaea(AOA)amoA,AOB amoA,nirK and nirS genes in both wheat and maize seasons,while increased abundance of nosZ gene in maize season,leading to lower soil N2O emissions.Changes in these functional genes correlated significantly with soil moisture,nitrogen availability,and enzyme activity(L-leucine aminopeptidase and Urease).Besides,diversified rotations increased number of nodes,edges and degree of the co-occurring network and sub-network,while reduced average path length and betweeness.These microbial co-occurrence network complexity indicators were significantly correlated with N2O emissions.This indicates that increase in aboveground crop diversity drives the increase in complexity of belowground N-cycling related microbial interaction networks,which leads to lower N2O emissions.In summary,diversified rotations show promising potentials to lower N2O emissions in agricultural soils.
摘要While the complexity of fifth-generation wireless networks is being widely commented upon,there is great anticipation for the arrival of the sixth generation(6G),with its enriched capabilities and features.It can easily be imagined that,without proper design,the enrichment of 6G will further increase system complexity.To address this issue,we propose the Agentic-AI Core(A-Core),an artificial intelligence(AI)-empowered,mission-oriented core network architecture for next-generation mobile telecommunications.In A-Core,network capabilities can be added and updated on the fly and further programmed into missions for enabling and offering diverse services to customers.These missions are created and executed by autonomous network agents according to the customer's intent,which may be expressed in natural language.The agents resolve intents from customers into workflows of network capabilities by leveraging a large-scale network AI model and follow the workflows to execute the mission.As an open,agile system architecture,A-Core holds promise for accelerating innovation and greatly reducing standard release times.The advantages of A-Core are demonstrated through two use cases.
基金supported by the National Level Project of China(No.KJSP2023020201)the Foundation of Science and Technology on Aerospace Flight Dynamics Laboratory of China(No.kjw6142210240202)+1 种基金the Beijing Institute of Technology Research Fund Program for Young Scholars of Chinathe Fundamental Research Funds for Central Universities of China。
摘要In recent years,the rapid development of mega-constellations has significantly exacerbated the deterioration of the space debris environment,posing substantial and escalating threats to the safety of spacecraft.This study aims to explore the complex evolution of the space debris environment and assess the collision risks associated with spacecraft.First,a space debris environment topological network model is proposed,which incorporates interdisciplinary methods from topological networks,fluid mechanics,and spacecraft dynamics.This model enables a structured representation of the relationships among space objects and provides rapid predictions of the space debris environment.Then,a collision probability algorithm based on the topological network model is introduced.This algorithm inherits the efficiency advantages of the topological network model and has been validated for reliability through comparison with the classical ESA’s DRAMA software.Finally,based on the above models,the collision risks of constellation satellites in Low Earth Orbit(LEO)are analyzed,including both operational and deorbit processes.The study reveals that constellation satellites face a much higher risk of internal collisions with satellites from the same constellation during operations than that with other space objects.Additionally,during the satellite deorbit process,the collision risk peaks when satellites traverse the operational region of Starlink satellites.
基金supported in part by the National Natural Science Foundation of China under Grant 62171449。
摘要This comprehensive survey paper examines the applications of Artificial Intelligence(AI)in Unmanned Aerial Vehicle(UAV)-enabled wireless networks.With the increasing demand for efficient and adaptive communication systems,the integration of AI with UAV networks promises to revolutionize various aspects of wireless communication.The paper first outlines the background and motivation behind AI integration,highlighting the potential for enhanced network performance,autonomy,and adaptability.It then delves into the key AI applications across different network layers,including data sensing and collection,placement and trajectory optimization,radio resource management,routing and topology control,edge computing and caching,as well as security and privacy enhancement.For each application,the paper discusses relevant AI techniques,main findings,optimization objects,and the potential benefits and challenges.The survey also identifies open issues,such as the practical implementation gap,standardization issues,and real-world application barriers,and proposes future directions to address these challenges and further advance the field.In conclusion,the integration of AI with UAV-enabled Wireless Networks(UWNs)holds tremendous potential for transforming wireless communication,enabling new applications and services with unprecedented capabilities.
基金supported by the National Key Research and Development Program Young Scientist Project(Grant No.2024YFC2911000)the National Natural Science Foundation of China(Grant No.52474103)the Major Basic Research Project of the Natural Science Foundation of Shandong Province(Grant No.ZR2024ZD22).
摘要Internal structural defects in engineering rock masses vary in size,exhibit complex shapes,and are unevenly distributed.Dominant fractures within a rock mass often play a critical to its mechanical behavior,directly affecting the macromechanical properties and failure modes.These fractures affect the instability and failure of the surrounding rock,significantlyimpacting the overall stability of engineering structures.Herein,sand-powder three-dimensional(3D)printing technology was used to prepare rock-like specimens with internal fracture networks.Triaxial compression testing,post-failure fracture mapping,and fractal dimension analysis of the fracture surfaces were conducted to investigate the effects of dominant fracture angles on the strength and deformation of rocks with internal fracture networks under triaxial stress.The results indicate that the dominant fracture angle has a pronounced effect on the mechanical behavior of rock.With increasing angle,both compressive strength and elastic modulus exhibit an initial decline followed by an increase.Moreover,higher confiningpressure significantlyimproves the compressive strength of fractured rock.This enhancement weakens as the confiningpressure further increases.Moreover,with increasing confiningpressure,the differences between the maximum and minimum values of elastic moduli and lateral strain ratios in fractured rock gradually decrease.Thus,the impact of the dominant fracture angle on rock mass deformation decreases with increasing confiningpressure.This research elucidates the effects of dominant fracture angles on the mechanical and failure properties of complex fractured rock masses and the influenceof the confiningpressure on these relationships.It provides valuable theoretical insights and practical guidance for stability analyses in engineering rock masses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
摘要This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金supported by the China Agricultural Research System(Grant No.CARS-09)the Central Government Guiding Local Science and Technology Development Project(Grant No.YDZX2023029)the Gansu Planning Projects on Science and Technology(Grant No.23CXNJ0013).
摘要Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established.
基金supported by National Science and Technology Major Project"CO2 Flooding for Significantly Enhancing Recovery Rate and Long-Term Sequestration Technology"(No.2024ZD1406601)National Natural Science Foundation of China(Nos.42272186,42472179,42302128,42202109)+1 种基金Frontier Interdisciplinary Exploration Research Program of China University of Petroleum,Beijing(No.2462024XKQY003)Science Foundation of China University of Petroleum(Beijing)(Nos.2462023BJRC024,and 2462023YJRC039)。
摘要Sedimentary facies modeling is a critical approach for understanding geological phenomena,yet the strong heterogeneity of reservoir systems poses a serious challenge for their refined characterization.In this study,we innovatively propose an interpretable attention-guided generative adversarial network framework with dual-domain learning,which achieves precise sedimentary facies modeling under the constraints of well facies and soft probability data.Specifically,we first effectively extract and preserve prior information of sedimentary facies models from both spatial and frequency domain perspectives.Then,during simulation,to enhance the capability of the network model for finely characterizing complex heterogeneous models,cross-spatial attention mechanisms are designed to effectively capture short-range and long-range dependencies between multi-scale pattern features.Additionally,through systematic feature map visualization analysis,we elucidate the processes of conditional fitting and complex sedimentary facies model reconstruction,intuitively demonstrating the functional mechanisms of each module.Finally,systematic experiments are conducted on multiple datasets to validate the effectiveness of the proposed method.The results demonstrate that the generated sedimentary facies models exhibit high consistency with training datasets in terms of visual realism and statistical indicators.Quantitative comparisons reveal remarkable performance of the method,achieving low Wasserstein distance(0.09),Kernel Inception Distance(0.0017)and Kernel Maximum Mean Discrepancy(0.21).These findings further confirm the high realism of the generated realizations regarding pattern features.This study offers a reliable and practical method for geological reservoir modeling,thereby advancing quantitative,precise geological research with broad application prospects.
基金National Key Research and Development Program of China,No.2019YFD1101304National Natural Science Foundation of China,No.52278059+1 种基金Natural Science Foundation of Hunan Province of China,No.2024JJ8316Hunan Provincial Innovation Foundation For Postgraduate,No.CX20250634。
摘要Urban spatial morphology(USM)optimization is critical to balancing biodiversity conservation and sustainable urbanization.However,previous studies predominantly focused on the socio-economic efficiency and static ecological metrics and rarely addressed the dynamic USM optimization across spatial scales.Here,we developed a multi-level ecological network(MEN)framework to resolve the tension between urban expansion and ecological integrity.By integrating the cost-weighted distance analysis with a hierarchical network transmission mechanism,we established a cross-scale spatial optimization system,which coordinated the regional ecological corridors and local habitat patches.Comparative experiments with conventional single-scale approaches and scenario simulations using the PLUS model show that the MEN framework had superior performance in three dimensions:(1)spatial governance:the primary-level network(peri-urban natural reserves)effectively contained urban sprawl,and the secondary-level network(intra-urban green corridors)mitigated habitat fragmentation and improved the built-environment;(2)scenario robustness:the model maintained an optimal compactness-loose balance in multiple development pathways;(3)landscape metrics:patch fragmentation decreased by 18.25%,and the internal landscape richness improved by 10.66%compared to the scenario without USM optimization.The findings provide new insight to establish a hierarchical ecological optimization framework as a nature-based spatial protocol to reconcile metropolitan growth with landscape sustainability.
基金supported by the National Natural Science Foundation of China(Nos.52473080,52403167 and 52173079)the Fundamental Research Funds for the Central Universities(Nos.xtr052023001 and xzy012023037)+1 种基金the Postdoctoral Research Project of Shaanxi Province(No.2024BSHSDZZ054)the Shaanxi Laboratory of Advanced Materials(No.2024ZY-JCYJ-04-12).
摘要Shape memory polymers used in 4D printing only had one permanent shape after molding,which limited their applications in requiring multiple reconstructions and multifunctional shapes.Furthermore,the inherent stability of the triazine ring structure within cyanate ester(CE)crosslinked networks after molding posed significant challenges for both recycling,repairing,and degradation of resin.To address these obstacles,dynamic thiocyanate ester(TCE)bonds and photocurable group were incorporated into CE,obtaining the recyclable and 3D printable CE covalent adaptable networks(CANs),denoted as PTCE1.5.This material exhibits a Young's modulus of 810 MPa and a tensile strength of 50.8 MPa.Notably,damaged printed PTCE1.5 objects can be readily repaired through reprinting and interface rejoining by thermal treatment.Leveraging the solid-state plasticity,PTCE1.5 also demonstrated attractive shape memory ability and permanent shape reconfigurability,enabling its reconfigurable 4D printing.The printed PTCE1.5 hinges and a main body were assembled into a deployable and retractable satellite model,validating its potential application as a controllable component in the aerospace field.Moreover,printed PTCE1.5 can be fully degraded into thiol-modified intermediate products.Overall,this material not only enriches the application range of CE resin,but also provides a reliable approach to addressing environmental issue.
基金supported by Yunnan Fundamental Research Projects(202501BD070001-081).
摘要Urbanization is a significant driver of the loss of biodiversity and the disruption of ecosystems.Amphibians are especially vulnerable to the negative impact of urbanization as their life cycles and habitat requirements are complex.The present study investigated the effects of urbanization on amphibian predation networks in suburban Kunming in Yunnan,China and aimed to understand how predation network structure and stability vary with urbanization level.We constructed predation networks by analyzing the stomach contents of amphibians from 12d istinct urbanization gradients.We used the bipartite package in R to evaluate network robustness metrics such as modularity,nestedness,connectivity,and average shortest path length(ASPL).We found that urbanization level is negatively correlated with predation network connectivity(R=−0.67,Ρ=0.02),but there were no significant correlations between urbanization level and nestedness,modularity,or ASPL.Removal of the keystone species destabilized the predation networks at certain locations.The present work highlighted that maintaining prey quantity and diversity preserves predation network connectivity and stabilizes the overall network in urbanizing landscapes.It also underscored the critical role that keystone species play in sustaining network robustness.The results of this research provided insights into the ecological consequences of urbanization.They also suggested that conservation measures should protect the key species and habitats of amphibian predation networks and mitigate the negative impact of urban development on them.
基金supported by the National Natural Science Foundation of China(62173002,62403235,62403010,52301408,62173255)the Beijing Natural Science Foundation(L241015,4222045)+2 种基金the Yuxiu Innovation Project of NCUT(2024NCUTYXCX111)the China Postdoctoral Science Foundation(2025T180466)the Beijing Postdoctoral Research Foundation(2025-ZZ-70)。
摘要Networked predictive control(NPC) has gained significant attention in recent years for its ability to effectively and actively address communication constraints in networked control systems(NCSs),such as network-induced delays,packet dropouts,and packet disorders.Despite significant advancements,the increasing complexity and dynamism of network environments,along with the growing complexity of systems,pose new challenges for NPC.These challenges include difficulties in system modeling,cyber attacks,component faults,limited network bandwidth,and the necessity for distributed collaboration.This survey aims to provide a comprehensive review of NPC strategies.It begins with a summary of the primary challenges faced by NCSs,followed by an introduction to the control structure and core concepts of NPC.The survey then discusses several typical NPC schemes and examines their extensions in the areas of secure control,fault-tolerant control,distributed coordinated control,and event-triggered control.Moreover,it reviews notable works that have implemented these schemes.Finally,the survey concludes by exploring typical applications of NPC schemes and highlighting several challenging issues that could guide future research efforts.
基金funded by the Academic Backbone Support Project of the Northeast Agricultural University,China,the Natural Science Foundation of Heilongjiang Province,China(No.LH2021D014)the National Natural Science Foundation of China(No.41701289).
摘要Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricultural ecosystems.In this study,an 18-year-old alfalfa cultivation area within the saline-alkali Songnen Plain in Northeast China was selected to determine the contribution of the microbial network to the improvement of saline-alkali soils after alfalfa cropping.Our findings indicated that the multi-kingdom microbial network,comprising fungi,bacteria,and archaea,was more complex and stable than the single-kingdom networks.Specifically,the multi-kingdom network exhibited an increased number of nodes and connections,demonstrating higher complexity.By cultivating alfalfa in saline-alkali soils,fungal nodes in the multi-kingdom network demonstrated significantly higher degree and betweenness compared to bacterial nodes and archaeal nodes.Additionally,fungi had a higher natural connectivity,which contributed to the overall network stability.In contrast,the bacterial subset in the multi-kingdom network in bare land exhibited a higher degree,betweenness,and natural connectivity.Furthermore,changes in the topological properties of the microbial network,including its complexity and stability,were significantly correlated with environmental factors,such as soil electrical conductivity and pH.In conclusion,cultivating alfalfa stabilized the self-organization in the multi-kingdom network in saline-alkaline soils and increased the complexity and stability of the fungal network.These findings provide a foundation for further research into the role of multi-kingdom microbial communities in soil ecosystems.
基金Project supported by the China Atomic Energy Authority(CAEA)through the Geological Disposal ProgramProjects(U24A20616,U24B2038)supported by the National Natural Science Foundation of ChinaProject(2025-05)supported by the Guangdong Provincial Water Conservancy Science and Technology Innovation Project,China。
摘要Microseismic monitoring and signal recognition constitute critical technologies for accurately assessing rockburst risks and ensuring the safe construction of underground rock engineering.This study developed a"Surface+Underground"microseismic intelligent monitoring system to evaluate dynamic disaster risks during construction at the Beishan High-level Radioactive Waste Geological Disposal Laboratory in China.The datasets of four typical one-dimensional time-domain microseismic signals,including rock fracture,blasting,TBM tunneling,and drilling,were constructed,and the BO-CNN-LSTM model is developed to identify and classify these signals..Based on the classification results,the typical time-frequency domain characteristics of the four types of signals are analyzed.The classification results of BO-CNN-LSTM,CNN,LSTM and CNN-LSTM models show that the recognition accuracy of the four models is 98.0%,85.7%,66.7%and 91.0%,respectively.Among all types,the four models demonstrate the highest effectiveness in identifying rock fracture and borehole signals.The findings further confirm that the BO-CNN-LSTM model efficiently recognizes and extracts microseismic signal features,demonstrating superior performance and stability in the classification task.Finally,the study suggests several future research directions,particularly in the areas of raw signal denoising,and automation of feature extraction.
摘要Dear Editor,This letter presents a novel graph neural network, namely modularized graph convolution network(MGCN), to address the underexplored issue in graph convolution networks(GCNs), wherein the weights for neighbor aggregation are fixed, leading to the limited capability of capturing diverse relationships among nodes for representation learning. Conventional GCNs always learn node representations in the graph according to the weights computed from the graph Laplacian, consequently overlooking the similarity and group cohesiveness of node features.
基金financially supported by the National Science Foundation of China(Nos.22525106,52333001,22471164,52421006,22303050,and 22475128)the Shanghai Municipal Science and Technology Major Project and the Open Project of the State Key Laboratory of Supramolecular Structure and Materials(No.sklssm202518)the financial support of the Outstanding Doctoral Graduate Development Scholarship of Shanghai Jiao Tong University(SJTU Grants)。
摘要Covalent adaptable networks(CANs)have emerged as versatile platforms for sustainable polymer materials,where precise control over the dissociation/exchange kinetics of dynamic covalent bonds is essential for tuning their viscoelastic behaviors.Herein,we introduce a topology-preserving strategy to accelerate network relaxation by embedding slidable mechanically interlocked cross-links into vinylogous urethane-based CANs,yielding mechanically interlocked vitrimers(MIVs).The mechanically bonded junctions are constructed by incorporating kinetically stable acetoacetate-functionalized[2]pseudorotaxane cross-linkers through catalyst-free polymerization with diamines.Although exhibiting higher glass-transition temperatures than a control network with identical cross-linking density but fixed cross-links,the representative MIV-2 maintains comparable ductility while displaying greater toughness,indicating that the slidable cross-links effectively enhance chain sliding.At elevated temperatures,this chain sliding prominently accelerates stress relaxation in MIV-2,showing a substantial reduction in the apparent activation energy for vinylogous urethane exchange compared with the control(10.3 versus 21.2 kJ/mol).Unlike the control with fixed crosslinks,the chain motion enabled by mechanical bonds enhances the diffusion of dynamic covalent moieties,thereby effectively promoting bond exchange throughout the network.Owing to the associative nature of vinylogous urethane exchange,the mechanically bonded cross-links remain topologically constrained on the polymer chains during relaxation.Consequently,the accelerated stress relaxation originates from mechanical-bond-mediated chain sliding rather than defect generation,clearly distinguishing MIVs from defect-mediated dual-dynamic CANs designs commonly employed to promote relaxation.These results disclose how the mechanically interlocked structures regulate chemical reactions in cross-linked polymer networks,establishing a novel strategy of topology-engineering guided structural design for smart multidynamic polymers.
基金National Natural Science Foundation of China(82575255)Open Research Project of Jiangsu Provincial Research Institute of Chinese Medicine Schools(JSZYLP2024060)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24_2156).
摘要Objective To address the challenges of systematically identifying herb pairs in traditional Chinese medicine(TCM),we proposed HerbGL,a framework for predicting potential herb pairs that integrates network propagation and graph regularization.Methods Based on the assumption that herbal actions induce subtle perturbations in biological systems,a framework named HerbGL was proposed.Random walk with restart(RWR)was first applied to the protein-protein interaction(PPI)network to reconstruct herb-specific perturbation effects and generate weighted subnetworks.Then,to quantify affinity between herb pairs,two network-proximity metrics,Closeness and PageRank,were computed from the weighted subnetworks to construct herb-pair affinity matrices.Finally,these matrices,together with known herb pairs(derived from co-occurrence analysis of TCM formulas with a threshold determined from the inflection point of the frequency distribution),were incorporated into a graph regularization model to predict potential herb pairs.Model performance was assessed through baseline comparison,ablation and robustness experiment under different ratios of positive and negative samples,using the area under the receiver operating characteristic curve(AUROC),the area under the precision-recall curve(AUPRC),accuracy,and precision as evaluation metrics.Furthermore,the predicted herb pairs were validated through both literature evidence and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses.Results The weighted subnetworks constructed by RWR provided a refined simulation of herb-specific perturbation effects,which formed the basis for subsequent affinity modeling and prediction.Analysis of herb pair co-occurrence frequencies revealed a marked change around 150,which was selected as the threshold to distinguish herb pairs from non-herb pairs.HerbGL exhibited superior predictive performance compared with baseline models(AUROC=0.9705,AUPRC=0.9555,accuracy=0.7266,precision=0.9706).Ablation results showed that removing the Closeness and PageRank metrics substantially degraded performance(AUROC=0.8191,AUPRC=0.8768),confirming their necessity.Robustness evaluation under an imbalanced positive-to-negative sample ratio of 1:5 yielded AUROC=0.9696 and AUPRC=0.8404,indicating stable predictive ability.Moreover,multiple case studies further validated the rationality of the predicted herb pairs,such as Fangfeng(Saposhnikoviae Radix)and Qingpi(Citri Reticulatae Pericarpium Viride)which are recorded in Liangpeng Huiji(《良朋汇集》,Collection of Excellent Recipes)Vol.3:Fangfeng Shengma Tang(防风升麻汤).Additionally,pathway enrichment analysis of the Renshen(Ginseng Radix et Rhizoma)and Lianqiao(Forsythiae Fructus)pair further supported the biological plausibility of their compatibility.Conclusion HerbGL offers an effective and biologically informed framework for identifying herb pairs in TCM.Beyond improving herb pair prediction,the framework also provides data support for research on herb compounds and mechanisms,thereby supporting data-driven exploration of TCM compatibility.
基金supported by grants from the National Natural Science Foundation of China(52538010)the Guangzhou Municipal Education Bureau’s Scientific Research Project,China(2024312217)The financial support is gratefully acknowledged.
摘要In structural optimization,data-driven surrogate models are often explored as alternatives to finite element analysis to reduce computational cost.However,conventional neural networks usually fail to capture key structural characteristics and are limited to predicting global responses(e.g.,top displacement),but usually fail to achieve accurate internal force predictions with conventional training data volumes.As a result,most existing studies involving surrogate models did not concern internal force constraints.To address this issue,this study proposes a structural optimization framework based on a pre-trained Physics-Informed Neural Network(PINN)surrogate model.By embedding static equilibrium equation into the loss function,the model achieves higher predictive accuracy,particularly for internal forces,while pre-training accelerates convergence and enhances stability.Combined with an improved multi-swarm particle swarm optimization(MPSO)algorithm,the framework enables efficient optimization of multi-story frame structures under internal force and multiple other constraints.The application to a six-story frame structure validates its effectiveness:compared with a DNN-based model,the PINN-based model improves the coefficient of determination for internal force prediction from 0.8874 to 0.9937.These results demonstrate that the proposed method offers a promising approach for efficient optimization of multi-story frame structures.