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Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+T cells for triple-negative breast cancer therapy 认领 引用 被引量：2
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作者 Ting Yang Zihan Liu +9 位作者 Zixuan Fu Xiaojie Zhang Yongjin Cao Qiangwei Liang Jiale Miao Hao Yang Tong Zhang Jing Hei Weiqing Ni Yanhua Liu 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2025年第2期146-159,共14页
Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.Ho... Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.However,the ferroptosis accompanied with down-regulation of glutathione peroxidase 4(GPX4)lead to CD36-mediated tumor-infiltrating CD8+T cells uptaking fatty acids,resulting in the negative action on immunotherapeutic efficacy.Herein,the albumin nanoparticles,abbreviated as LHS NPs,were designed by co-assembly of hemin,linoleic acid-cystamine,and a CD36 inhibitor sulfosuccinimide oleate,to bi-directionally manipulated ferroptosis in tumor and CD8+T cells for TNBC therapy.LHS NPs exerted more efficient reactive oxygen species generation,glutathione depletion and malondialdehyde production by the combinatory strategy of classical and non-classical ferroptosis modes,which amplified the positive action on ferroptosis in tumor cells.Meanwhile,LHS manipulated the negative action of ferroptosis by inhibiting the CD36 mediated-lipid peroxidation in CD8+T cells,thereby activating the immunotherapeutic efficacy with the improvements on induction of immunogenic cell death,proliferation of CD4+CD8+T cells and natural killer cells,alleviation immunosuppressive regulatory T cells and myeloid-derived suppressor cells,and repolarization of the M2-to M1-phenotype tumor-associated macrophages.Thus,LHS NPs demonstrated an improved antitumor efficacy in suppressing the tumor growth and lungmetastasis of 4T1-tumormice.Our work gives novel insights for the bi-directionally manipulating ferroptosis in tumor and CD8+T cells on TNBC chemoimmunotherapy. 展开更多
关键词 Albumin nanoassembly Bi-directionally manipulated ferroptosis Lipid peroxidation CD36-mediated CD8+T cell ferroptosis Triple-negative breast cancer
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Chloroplast protein StFC-Ⅱwas manipulated by a Phytophthora effector to enhance host susceptibility 认领 引用 被引量：2
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作者 Meng Xu Xinyuan Sun +5 位作者 Xinya Wu Yetong Qi Hongjun Li Jiahui Nie Zhu Yang Zhendong Tian 《Horticulture Research》 SCIE CSCD 2024年第7期279-293,共15页
Oomycete secretes a range of RxLR effectors into host cells to manipulate plant immunity by targeting proteins from several organelles.In this study,we report that chloroplast protein StFC-Ⅱis hijacked by a pathogen ... Oomycete secretes a range of RxLR effectors into host cells to manipulate plant immunity by targeting proteins from several organelles.In this study,we report that chloroplast protein StFC-Ⅱis hijacked by a pathogen effector to enhance susceptibility.Phytophthora infestans RxLR effector Pi22922 is activated during the early stages of P.infestans colonization.Stable overexpression of Pi22922 in plants suppresses flg22-triggered reactive oxygen species(ROS)burst and enhances leaf colonization by P.infestans.A potato ferrochelatase 2(FC-Ⅱ,a nuclear-encoded chloroplast-targeted protein),a key enzyme for heme biosynthesis in chloroplast,was identified as a target of Pi22922 in the cytoplasm.The pathogenicity of Pi22922 in plants is partially dependent on FC-Ⅱ.Overexpression of StFC-Ⅱdecreases resistance of potato and Nicotiana benthamiana against P.infestans,and silencing of NbFC-Ⅱin N.benthamiana reduces P.infestans colonization.Overexpression of StFC-Ⅱincreases heme content and reduces chlorophyll content and photosynthetic efficiency in potato leaves.Moreover,ROS accumulation both in chloroplast and cytoplasm is attenuated and defense-related genes are down-regulated in StFC-Ⅱoverexpression transgenic potato and N.benthamiana leaves.Pi22922 inhibits E3 ubiquitin ligase StCHIP-mediated StFC-Ⅱdegradation in the cytoplasm and promotes its accumulation in chloroplasts.In summary,this study characterizes a new mechanism that an oomycete RxLR effector suppresses host defenses by promoting StFC-Ⅱaccumulation in chloroplasts,thereby compromising the host immunity and promoting susceptibility. 展开更多
关键词 host cells targeting proteins several organellesin chloroplast protein pathogen effector rxlr effectors enhance susceptibilityphytophthora infestans manipulate plant immunity leaf colonization
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Research & design on the drive system of nuclear fuel manipulate crane 认领 引用
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作者 穆兆辉 Li Weidong Liu Rao 《High Technology Letters》 EI CAS 2014年第4期446-450,共5页
The control of nuclear fuel manipulator crane （MC） drive system is essential for its running and other systems are designed surrounding the drive system.This paper gives a brief introduction to the composition and f... The control of nuclear fuel manipulator crane （MC） drive system is essential for its running and other systems are designed surrounding the drive system.This paper gives a brief introduction to the composition and function of MC,analyses its drive mode and control method and applies PLC to control its frequency transducer directly to help the motor work more stable.Based on the control requirements of bridge,trolley,Hoist,the control system of bridge applies a drive mode with 2-drag2 drive model on both sides and a multi-control method to realize simultaneous runningof two sides,1-drag-1 model on through-going axes and closed loop control method finish the precise location of trolley,and the using of 1-drag-1 model drive mode and closed loop control method solves the protect control difficulty of hoist which stops/starts repeatedly and changes speed. 展开更多
关键词 PMC manipulate crane （MC） drive system drive mode control method
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Minimally manipulated autologous adherent bone marrow cells (ABMCs):a promising cell therapy of spinal cord injury 认领 引用 被引量：3
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作者 Kamana Misra Hatem E.Sabaawy 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第7期1058-1060,共3页
Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorr... Spinal cord injury（SCI）is a devastating ailment that results in drastic life style alterations for the patients and their family members（Mc Donald and Sadowsky,2002）.Damage post injury causes necrosis,edema,hemorrhage and vasospasm.Post injury,secondary damage is caused by ischemia, 展开更多
关键词 bone cell Minimally manipulated autologous adherent bone marrow cells a promising cell therapy of spinal cord injury ABMCs MSCs
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Psoriasis treatment using minimally manipulated umbilical cordderived mesenchymal stem cells:A case report 认领 引用 被引量：5
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作者 Hyunjun Ahn Sang Yeon Lee +2 位作者 Won-Ju Jung Jia Pi Kye-Ho Lee 《World Journal of Clinical Cases》 SCIE 2021年第23期6798-6803,共6页
BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal keratinocytes.About 2%of the world’s population suffers from psoriasis b... BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal keratinocytes.About 2%of the world’s population suffers from psoriasis but there are no clear therapeutics yet.Recently,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without risks.Human umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune diseases.CASE SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in 1995.He had received various treatments for 25 years,but the psoriatic condition was not significantly improved.He was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 wk.The erythema gradually disappeared.Three months after the 1st round,all erythema completely disappeared,and the psoriasis did not recur.CONCLUSION Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis. 展开更多
关键词 Psoriasis Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report
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Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells:Three case reports and review of literature 认领 引用 被引量：6
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作者 Hyunjun Ahn Sang Yeon Lee +1 位作者 Won Ju Jung Kye-Ho Lee 《World Journal of Clinical Cases》 SCIE 2021年第15期3741-3751,共11页
BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis... BACKGROUND Alopecia areata(AA)is a common autoimmune disease characterized by hair loss.AA appears in extensive forms,such as progressive and diffusing hair loss(diffuse AA),a total loss of scalp hair(alopecia totalis),and complete loss of hair over the entire body(alopecia universalis).Recently,mesenchymal stem cells(MSCs)have been identified as a therapeutic alternative for autoimmune diseases.For this reason,preclinical and case studies of AA and related diseases using MSCs have been conducted.CASE SUMMARY Case 1:A 55-year-old woman suffered from AA in two areas of the scalp.She was given 15 rounds of minimally manipulated umbilical cord-MSCs(MM-UC-MSCs)over 6 mo.The AA gradually improved 3 mo after the first round.The patient was cured,and AA did not recur.Case 2:A 30-year-old woman,with history of local steroid hormone injections,suffered from AA in one area on the scalp.She was given two rounds of MM-UC-MSCs over 1 mo.The AA immediately improved after the first round.The patient was cured,and AA did not recur.Case 3:A 20-year-old woman,who was diagnosed with alopecia universalis at the age of 12,was given 14 rounds of MM-UC-MSCs over 12 mo.Her hair began to grow about 3 mo after the first round.The patient was cured,and alopecia universalis did not recur.CONCLUSION MM-UC-MSC transplantation potentially treats patients who suffer from AA and related diseases. 展开更多
关键词 Alopecia areata Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report
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Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation:A case report 认领 引用 被引量：4
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作者 Hyunjun Ahn Sang Yeon Lee +1 位作者 Won Ju Jung Kye-Ho Lee 《World Journal of Stem Cells》 SCIE 2021年第8期1151-1159,共9页
BACKGROUND Stroke is one of the major causes of disability and death worldwide.Some treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neurona... BACKGROUND Stroke is one of the major causes of disability and death worldwide.Some treatments for stroke exist,but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the brain.Recently,mesenchymal stem cells(MSCs)have been studied as a therapeutic alternative for stroke,and various preclinical and case studies have been reported.CASE SUMMARY A 55-year-old man suffered an acute stroke,causing paralysis in the left upper and lower limbs.He intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs(MM-UC-MSCs)twice with an 8-d interval.At 65 wk after transplantation,the patient returned to his previous occupation as a veterinarian with no adverse reactions.CONCLUSION MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke. 展开更多
关键词 Acute ischemic stroke Behavioral disorder Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report
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基于Manipulate的大学数学课件制作 认领 引用 被引量：1
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作者 段敏 《普洱学院学报》 2020年第6期29-31,共3页
数学课件制作难,难在于交互,自从Mathematica6版本中引入了Manipulate函数后,制作交互式图形用户界面的数学课件易如反掌。基于此,论述Manipulate函数制作大学数学课件的一般方法及注意事项。
关键词 Manipulate 课件 控件
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Laser-manipulated the of a harmonically multiphoton transitions trapped particle 认领 引用
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作者 陈琼 海阔 海文华 《Chinese Physics B》 CAS 2007年第12期3662-3667,共6页
A single particle magneto-confined in a one-dimensional （1D） quantum wire experiences a harmonic potential, and imposing a sharply focused laser beam on an appropriate site shapes a δ potential. The theoretical inv... A single particle magneto-confined in a one-dimensional （1D） quantum wire experiences a harmonic potential, and imposing a sharply focused laser beam on an appropriate site shapes a δ potential. The theoretical investigation has demonstrated that for a sufficiently strong δ pulse the quantum motional stationary state of the particle is one of the eigenstates of the free harmonic oscillator, and it is determined by the site of the laser beam uniquely, namely a quantum state is admissible if and only if the laser site is one of its nodes. The numerical computation shows that all the nodes of the lower energy states with quantum numbers n ≤ 20, except the coordinate origin, are mutually different. So we can manipulate the multiphoton transitions between the quantum states by adjusting the position of the laser δ pulse and realize the transition from an unknown higher excitation state to a required lower energy state. 展开更多
关键词 quantum wire magnetically trap laser manipulation multiphoton transition
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基于Manipulate的数值分析交互式课件制作 认领 引用
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作者 段敏 谢进 《合肥学院学报（综合版）》 2020年第5期141-144,共4页
论述了信息技术与教育教学深度融合的现状,指出了制作课件是提高教师TPACK素养的方法之一,以Mathematica软件中的Manipulate函数为桥梁,给出了数值分析交互式课件制作的方法及即时制作的可能性。
关键词 TPACK Manipulate 课件
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Using magnetic nanoparticles to manipulate biological objects 认领 引用 被引量：4
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作者 刘毅 高宇 徐臣杰 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第9期29-39,共11页
The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for control... The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for controlling and probing biological objects with a magnetic force. In the past decade, progress in the synthesis and surface engineering of MNPs has further enhanced this popularity. 展开更多
关键词 magnetic nanoparticles manipulation biological objects
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Pixelated liquid crystal programmable metasurface enabled multi-functional terahertz near-field wavefront manipulation 认领 引用
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作者 YUAN FU XIAOJIAN FU +4 位作者 LIFENG CHEN PENG WANG LIHAO HUANG JUN YANG TIE JUN CUI 《Photonics Research》 SCIE EI CAS CSCD 2026年第5期2068-2079,共12页
Reconfigurable intelligent surface(RIS)technology is believed to effectively solve the dilemma of terahertz wireless communication in non-line-of-sight scenarios.Notably,the deployment of large-scale RIS arrays at hig... Reconfigurable intelligent surface(RIS)technology is believed to effectively solve the dilemma of terahertz wireless communication in non-line-of-sight scenarios.Notably,the deployment of large-scale RIS arrays at high frequencies brings about significant near-field effects,resulting in extensive near-field areas,which provides the possibility for the application of near-field communication.In this paper,a pixelated liquid crystal program-mable metasurface(PLCPM)is proposed to effectively manipulate terahertz waves in the near-field region.Leveraging the tunability of liquid crystal(LC)materials,the proposed PLCPM achieves 1-bit phase coding capability within the 104-110 GHz frequency band. 展开更多
关键词 multi functional terahertz near field wavefront manipulation manipulate terahertz terahertz wireless communication reconfigurable intelligent surface pixelated liquid crystal programmable metasurface non line sight scenarios near field communication reconfigurable intelligent surface ris technology
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Multi-material and multi-module freestanding microrobot for cargo transportation 认领 引用 被引量：3
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作者 Jian-Miao Zhang Xin-Yi Wu +5 位作者 Qi Duan Fan-Chun Bin Jie Liu Xian-Zi Dong Feng Jin Mei-Ling Zheng 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期780-793,共14页
Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under ext... Microrobots play an essential role in early diagnosis and precision medicine with the increasing demands for controllability in bio-medicine and micromanipulation,which can complete the pre-designed behavior under external stimulation.However,most microrobots are currently made of a single material system and focus on fabricating a driving module as the main structure of microrobots.This hinders the integration of diverse functions in one microrobot to fulfill the complex application.Here,a multi-material and multi-module hand-microrobot based on femtosecond laser direct writing technology is proposed,which has a pH-responsive capturing module and a magnetic-responsive transportation module(MRTM).This microrobot can not only respond to pH for capturing and releasing objects,but also respond to magnetic fields for cargo delivery even with obstacles.The two responding modules of the hand-microrobot are fabricated independently,and can collaborate with each other to achieve the delivery of target objects like polystyrene(PS)microsphere(10µm)or 786-O cell by capturing,transporting,and spatial rolling.Besides,the MRTM can be locally fabricated on any prefabricated static structure,so that the whole microrobot can achieve controllable motion.This strategy is expected to be used to manipulate cells,deliver drugs for precise treatment,and environmental treatment. 展开更多
关键词 hand-microrobots multi-module manipulation cell transportation femtosecond laser direct writing
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Pressure-Enhanced Intrinsic Anomalous Hall Conductivity in the Kagome Ferrimagnet TbMn6Sn6 认领 引用
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作者 Hao Sun Jiabin Qiao +13 位作者 Weian Guo Pengyu Zheng Yuwei Liu Pengda Ye Yuemei Li Shucui Sun Deng Hu Yongkai Li Yanpeng Qi Zhiwei Wang Meiling Jin Jie Chen Zhiping Yin Xiang Li 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第3期102-117,共16页
The kagome ferrimagnet TbMn6Sn6,featuring a pristine Mn kagome lattice,has emerged as a candidate Chern magnet with a large intrinsic anomalous Hall effect(AHE).While chemical substitution can modulate its prope... The kagome ferrimagnet TbMn6Sn6,featuring a pristine Mn kagome lattice,has emerged as a candidate Chern magnet with a large intrinsic anomalous Hall effect(AHE).While chemical substitution can modulate its properties,hydrostatic pressure provides a disorder-free route to manipulate electronic and magnetic interactions.Herein,we investigate the effects of hydrostatic pressure on electrical and magneto-transport in TbMn6Sn6 up to 18.3 GPa.Pressure significantly enhances hysteresis in the magnetoresistance and Hall responses,causing a concurrent monotonic coercive field increase,suggesting the enhancement of interlayer magnetic couplings in a robust c-axis ferrimagnetic order.The intrinsic anomalous Hall conductivity increases considerably from 129.5 S·cm−1 at ambient pressure conditions to 448.7 S·cm−1 at 14.0 GPa—an enhancement of 247%that is unprecedented among pressure-tuned kagome magnets.Based on density functional theory calculations,we reveal that pressure induces multiple gap openings near the Fermi level,giving rise to pronounced Berry curvature hotspots that may contribute to the AHE.Our results show that pressure can be used to enhance the intrinsic topological responses of this kagome magnet. 展开更多
关键词 chern magnet mn kagome latticehas anomalous hall effect ahe enhances hysteresis magnetoresistance kagome ferrimagnet chemical substitution hydrostatic pressure manipulate electronic magnetic interactionshereinwe
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All-flexible self-cleaning hydrogel smart window with multifunctionality based on an electro-thermal manipulator 认领 引用 被引量：1
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作者 Chao Chen Sijia Guo +5 位作者 Long Zhang Bingrui Liu Zhaoxin Lao Shuyi Li Yanlei Hu Dong Wu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期669-684,共16页
Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limita... Smart windows that can repel diverse liquids are highly attractive for the development of self-cleaning building system.Despite immense achievements having been made in drophobic smart windows,unfortunately,the limitations of inferior transparency,unsatisfactory flexibility,and scarce functionality greatly hinder their practical applications.Here,a multifunctional,all-flexible and slef-cleaning electrothermal-actuated(SETA)module with superior transparency is developed by sandwiching the hydrophobic SiO2 nanoparticles decorated silver nanowires thin-film heater and the thermo-responsive hydrogel.Through loading/discharging an electric stimulus of 5 V,the optical visibility of SETA could be in situ switched between an opaque state(T550=11.0%)and a transparent state(T550=84.9%)relying on the dynamically collapsed and swollen transition of hydrogel on planar and three-dimensional curved surfaces.Moreover,SETA chipset is able to repel diverse liquids,including organic and inorganic species,showcasing an excellent self-cleaning capability.Lastly,all-in-one multifunctionalities,including pixelated display,thermal regulation,defogging,and self-cleaning on a single SETA chipset,are successfully deployed.Compared to the previous windows,the current SETA chipset is more competent for optical switching in reality,owing to its portable,energy-efficient,flexible,highly-transparent,and on-demand manipulating advantages.This work provides inspirations for self-cleaning greenhouse,tunable optics,intelligent vehicles,and so on. 展开更多
关键词 femtosecond laser hydrophobic surface stimulus-responsive manipulator self-cleaning switchable clarity
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Graphene‑Skinned Fiber with Fine‑Tunable Electrical Resistance via Radical and Substrate Engineering for Electromagnetic‑Thermal Fabric 认领 引用
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作者 Jie Liang Zhaochen Li +4 位作者 Fang Ye Yuchen Cao Yi An Xiaomeng Fan Qiang Song 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第8期215-234,共20页
This work demonstrates a radicalmanipulation strategy for synthesizing graphene(Gr)-skinned SiO2 fabric via low-pressure chemical vapor deposition using methanol precursor.Controlled pyrolysis at high temperature regu... This work demonstrates a radicalmanipulation strategy for synthesizing graphene(Gr)-skinned SiO2 fabric via low-pressure chemical vapor deposition using methanol precursor.Controlled pyrolysis at high temperature regulated C1/C2/C6 radical ratios,enabling microstructure engineering.Substrate effects governed bilayer evolution.SiO2 imposed lower adsorption energy of C1 and higher diffusion barriers of radical compared to Gr,promoting edge defects in subsurface G1-type Gr layers,whereas reduced substrate constraints facilitated low-defect G2-type Gr growth on top of G1-type Gr.Synergistic control of gas-phase kinetics and substrate dynamics enabled fine-tunable sheet resistance(26-150Ωsq−1),establishing Grskinned fibers as multifunctional platforms for integrated electromagnetic-thermal management systems.When addressing the needs of electromagnetic communication and electrothermal deicing,laser-etched band-pass frequency selective surface structures of Gr-skinned fabric were fabricated to achieve electromagnetic wave(EMW)transmittance while maintaining Joule heating capability.A sandwich structure was prepared by laminating the Gr-skinned fabric with EMW transparent sheets exhibiting voltage-dependent transmittance,simultaneously sustaining broadband transmission and effective heating.This work demonstrates a strategy to mitigate the longstanding conductivity-EMW transparency trade-off in Gr-functionalized fibers through a multiscale engineering that coordinates microscopic structural regulation with macroscopic patterning,thereby unlocking next-generation smart composites for 5G/6G wearables,aerospace radomes,and beyond. 展开更多
关键词 Graphene Fiber Radical manipulation Electromagnetic wave Joule heating
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Optimal design of a novel dual-axis parallel solar tracker 认领 引用
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作者 Bin Zhu Liping Wang +2 位作者 Jun Wu Hengchun Cui Yanling Tian 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第2期167-179,共13页
Being renewable and readily available,solar energy has gained significant attention in addressing the global energy crisis and climate change.The efficiency of solar-energy harvesting using a concentrator depends on t... Being renewable and readily available,solar energy has gained significant attention in addressing the global energy crisis and climate change.The efficiency of solar-energy harvesting using a concentrator depends on the angle between the incident sunlight and the solar concentrator.Therefore,a solar-energy collection system equipped with a solar tracker that follows the apparent motion of the sun offers the highest collection efficiency.In this study,a novel solar tracker with a parallel mechanism is proposed based on the line graph method.The proposed parallel solar tracker(PST) features a main column with passive movements and two UPU chains that share a common constraint.This design enhances the rotational workspace,stiffness,and load-bearing capacity of the system.To solve the forward kinematics problem of the PST efficiently and accurately,a geometric elimination method is employed,converting the three-dimensional kinematics into a simpler planar problem.This allows the forward kinematics problem to be solved analytically using planar equations.By considering key performance indices,such as the effective workspace,transmission,and manipulability,the structural parameters of the PST are optimized in two steps,thereby identifying the optimal region in the design space.Finally,the computational efficiency and accuracy of both the forward and inverse kinematic solutions for the PST with optimized structural parameters are validated,demonstrating their potential for use in real-time control systems.The proposed novel solar tracker has high stiffness and load-bearing capacity.The study provides a solid foundation for improving the efficiency of solar energy utilization. 展开更多
关键词 Solar tracker Parallel mechanism Forward kinematics Effective workspace Transmissibility Manipulability
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Advances in Surface/Interface Engineering of Under-Water Superaerophobic Electrodes for Hydrogen Evolution Reaction by Manipulating of Bubbles 认领 引用
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作者 Annan He Fengxiang Chen +5 位作者 Jun He Xian Zhang Shangzhen Xie Na Yao Zhiguang Guo Weilin Xu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第10期512-550,共39页
The ever-increasing consumption of fossil fuels has led to environmental crises,which accelerated the quest for sustainable hydrogen energy.Among various production routes,water electrolysis stands out as a promising ... The ever-increasing consumption of fossil fuels has led to environmental crises,which accelerated the quest for sustainable hydrogen energy.Among various production routes,water electrolysis stands out as a promising approach.However,the efficiency of hydrogen evolution reaction is limited by the adhesion of gas bubbles on electrode surfaces,which blocks active sites,increases overpotential,and limits mass transfer.This review highlights the design of microanostructured array electrodes to achieve underwater superaerophobicity,reducing bubble adhesion,facilitating the nucleation and rapid release of ultrasmall bubbles,thereby contributing to reduce in overpotential,faster bubble growth,enhanced mass transport,and improved catalyst stability.We summarize recent advances in fabrication strategies of such electrodes,focusing on microanostructural designs,covering from 0 to 3-dimensional structures.Additionally,the role of hydrophilic gels in optimizing superaerophobicity is discussed.Finally,challenges and future directions are addressed,including bubble dynamics accurate modeling,development of high activity and stability catalysts,intelligent adaptive electrode structure and active bubble regulation,and the integration of artificial intelligence and deep learning for guided electrode design.This review aims to provide a comprehensive perspective on how superaerophobic electrode design address bottlenecks in gas-evolving electrodes,paving the way toward more efficient and economical hydrogen production. 展开更多
关键词 Hydrogen evolution reaction Superaerophobic electrodes Microanostructure Bubble manipulation Electrocatalysis
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Dynamicmanipulation ofmultiphase fluid inmicrogravity using photoresponsive surfactant 认领 引用
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作者 Xichen Liang Kseniia M.Karnaukh +7 位作者 Qixuan Cao Marielle Cooper Hao Xu Ian Maskiewicz Olivia Wander Javier Read de Alaniz Yangying Zhu Paolo Luzzatto-Fegiz 《Droplet》 EI CSCD 2026年第3期111-121,共11页
Control of bubble motion is essential for improving efficiency and creating new functionalities in electrochemistry,heat transfer,and biomedical systems.Photoresponsive surfactants enable bubble manipulation by creati... Control of bubble motion is essential for improving efficiency and creating new functionalities in electrochemistry,heat transfer,and biomedical systems.Photoresponsive surfactants enable bubble manipulation by creating surface-tension gradients,inducing a“photo-Marangoni”flow under illumination,without the need for engineered substrates,by leveraging a reversible switch in molecular conformation.Although previous studies have demonstrated bubblemanipulation using photo-responsive surfactants,a comprehensive understanding of how fluid behavior is affected by critical parameters,such as bubble size,illumination,photo-switching kinetics,concentration,and adsorption/desorption kinetics,remains elusive.Advances have been limited by the complex multiphysics processes involved,and by the fact that earth-bound experiments couple bubble photo-Marangoni dynamics with interference from buoyancy and photo-thermal convection.We elucidate the factors enabling fast photo-Marangonidriven bubble motion,by performing microgravity experiments,enabled by a bespoke photo-surfactant,complemented by a detailed modeling framework.We identify an optimal bubble size for migration(radius∼1 mm),since smaller and larger bubbles incur weaker photo-Marangoni stresses and larger drag,respectively.Surfactants that switch rapidly under illumination drive fastmigration,provided their reverse switch(in darkness)is 10-100×slower.These foundational results enable the synthesis of nextgeneration photo-surfactants and photo-Marangoni manipulation across multiphase fluid systems. 展开更多
关键词 engineered substratesby improving efficiency dynamic manipulation creating new functionalities bubble manipulation multiphase fluid reversible switch molecular conformationalthough electrochemistryheat transferand
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