期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到195篇文章
< 1 2 … 10 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Chronic alcohol consumption on retinal microcirculation in healthy subjects:an optic coherence tomography angiography study 认领 引用
1
作者 Dilan Yildiz Tahsin Uzundede +2 位作者 Akin Cakir Gamze Karatas Busra Coban 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2026年第2期326-332,共7页
AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This o... AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This observational clinical study utilized a cross-sectional and prospective design,focusing on chronic alcohol consumers alongside a non-consuming control group.OCT/OCTA imaging parameters including central retinal subfield thickness(CST),subfoveal choroidal thickness(SCT),foveal avascular zone(FAZ)and vessel density(VD)in the superficial and deep capillary plexuses in both the macular and optic disc(OD)regions were recorded.Data were analyzed using SPSS 15.0;descriptive statistics were reported,group comparisons were performed with Chisquare,Kruskal–Wallis,and Bonferroni-corrected Mann–Whitney U tests,and relationships were assessed using Spearman correlation,with statistical significance set at P<0.05.RESULTS:A total of 160 eyes of 160 participants(110 females and 50 males with mean age 38.7±9.9y)who don’t smoke were divided into five groups:never,occasional,monthly,weekly and daily drinkers.The mean CST was 216.6±14.2μm and the mean SCT was 358.9±84.5μm.There was no statistically significantly difference in CST and SCT among the groups(P=0.890,0.799).Foveal superficial capillary plexuses(SCPs)VD was higher in monthly drinkers compared to occasional drinkers(P=0.015).Foveal VD in deep capillary plexus was also higher in monthly drinkers than in never and occasional drinkers(P=0.004,0.006).Nasal SCPs VD at the OD was higher in monthly drinkers compared to never drinkers(P=0.005).There was no significant difference FAZ area among the groups(P=0.071).CONCLUSION:Both superficial and deep microvascular structures in the inferior quadrants of macula are positively correlated with frequency of alcohol use.Also in our study results is that the monthly drinker group has uniquely higher VDs in both macula and OD.This leads us to consider moderate alcohol consumption may also have protective effects on retinal microcirculation. 展开更多
关键词 alcohol consumption foveal avascular zone retinal microcirculation optical coherence tomography angiography vessel density
暂未订购 下载PDF
Septic shock reduces intestinal microcirculation and anastomotic perfusion:A porcine laser speckle contrast imaging study 认领 引用
2
作者 Rupan Paramasivam Claudia Jaensch +5 位作者 Nickolai M Kristensen Susie Sarah Paramasivam Helen Woldeselassie Louise Kruse Jensen Anders Husted Madsen Mai-Britt Worm Ørntoft 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期335-345,共11页
BACKGROUND Septic shock disrupts systemic and organ-specific microcirculation,leading to poor tissue perfusion and impaired healing.While mesenteric hemodynamics have been studied,the impact of sepsis on intestinal mi... BACKGROUND Septic shock disrupts systemic and organ-specific microcirculation,leading to poor tissue perfusion and impaired healing.While mesenteric hemodynamics have been studied,the impact of sepsis on intestinal microcirculation and anastomotic healing remains unclear.AIM To assess the short-term effects of septic shock on microcirculation in the small intestine and colon,with a focus on hand-sewn and stapled anastomoses,using laser speckle contrast imaging(LSCI).METHODS Ten pigs underwent midline laparotomy with the creation of four anastomoses:One hand-sewn and one stapled anastomosis in both the small intestine and colon.LSCI measurements were taken before anastomosis formation(TB),immediately after(TA),and after one hour of rest(T0).Septic shock was induced via intravenous Escherichia coli infusion,with subsequent LSCI measurements at 30-minute intervals(T30-T150).Results were expressed as relative changes compared to TB.RESULTS Septic shock significantly reduced microcirculation in both untouched intestine and anastomoses.Hand-sewn anastomoses consistently exhibited higher perfusion than stapled anastomoses.At T150,perfusion in hand-sewn anastomoses remained significantly higher than in stapled anastomoses(51%vs 34%of TB,P=0.002).CONCLUSION This study shows that septic shock significantly impairs intestinal microcirculation indicating a risk of intestinal ischemia if bacteriaemia and subsequent septic shock is untreated.Due to diminish blood flow following septic shock,the anastomotic healing may be compromised leading to increased risk of anastomotic leakage.Conclusively,this study provides a foundation for optimizing surgical strategies and improving patient outcomes in this high-risk population. 展开更多
关键词 Sepsis Intestinal anastomoses Microcirculation Anastomotic perfusion Porcine model Laser speckle contrast imaging
暂未订购 下载PDF
Mechanistic insights into“Three Methods and Three Acupoints”Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats 认领 引用 被引量：1
3
作者 Hanyu Zhang Yingqi Zhang +6 位作者 Hourong Wang Jiayue Liu Jiawei Sun Jinping Chen Zhifeng Liu Tianyuan Yu Jian Shu 《Journal of Traditional Chinese Medical Sciences》 CAS CSCD 2025年第1期125-134,共10页
Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to ... Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to four groups:normal,sham operation,model,and TMTP Tuina.Successful model induction was confirmed by observable hind limb lameness.After 20 sessions,hind limb grip strength and motor nerve conduction velocity(MNCV)were measured at baseline and following the 10th and 20th intervention.CD31 and a-SMA in the ventral horn of SNI model rats were detected using immunofluorescence.Motor neurons in the ventral horn were detected by Nissl staining.PTEN levels in the ventral horn were measured by ELISA,and PI3K,Akt,BDNF,VEGF,and HIF-1a expression was determined by RT-PCR.Spinal cord microcirculation was evaluated by western blotting analysis of the levels of Akt,p-Akt,BDNF,and VEGF.Results:Hind limb grip strength and MNCV significantly improved in the TMTP Tuina group compared to the model group(both P<.001).Morphology of ventral horn motor neurons in the TMTP Tuina group improved compared to the model group,with increased expressions of a-SMA(P=.002)and CD31(P=.006).Western blot analysis indicated increased expression of VEGF(P=.005),p-Akt(P<.001),and BDNF(P=.008)in the ventral horn following Tuina treatment.RT-PCR analysis revealed increased expression of PI3K,Akt,BDNF,VEGF and HIF-1a(all P<.05).In contrast,expression of PTEN decreased compared to the model group(P<.001).Conclusion:TMTP Tuina therapy may restore motor function in rats,enhance ventral horn motor neuron morphology,and promote angiogenesis and vascular smooth muscle proliferation.The mechanism may involve the activation of the PI3K/Akt signaling pathway. 展开更多
关键词 Three Methods and Three Acupoints Tuina Spinal cord Microcirculation PI3K/Akt
暂未订购 下载PDF
Toward realistic pharmaceutical evaluation:Challenges in 3D-printed organ chip of vascularized tissue with microcirculation 认领 引用
4
作者 Ling Wang Ziyan Qiu +2 位作者 Yingjie Liu Fei Wang Dichen Li 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2025年第9期1939-1941,共3页
Drug development and precision therapy are core technologies in thebiopharmaceutical field.In the traditional paradigm,new drug development relies on validation through animal testing and clinical trials—a process th... Drug development and precision therapy are core technologies in thebiopharmaceutical field.In the traditional paradigm,new drug development relies on validation through animal testing and clinical trials—a process that requires a decade of testing and costs over two billion dollars[1].Although animal testing has long served as the standard approach for evaluating drug efficacy and toxicity,its predictive accuracy for human responses remains limited due to translational barriers arising from interspecies physiological differences[2]. 展开更多
关键词 realistic pharmaceutical evaluation D printed organ chip clinical trials vascularized tissue drug development microcirculation animal testing precision therapy
暂未订购 下载PDF
Strain-and sex-dependent variability in hepatic microcirculation and liver function in mice 认领 引用
5
作者 Bing Wang Yuan Li +9 位作者 Qin Ouyang Meng-Ting Xu Ying-Yu Wang Sun-Jing Fu Wei-Qi Liu Xue-Ting Liu Hao Ling Xu Zhang Rui-Juan Xiu Ming-Ming Liu 《World Journal of Gastroenterology》 SCIE CAS 2025年第15期79-95,共17页
BACKGROUND The integrity and functionality of the hepatic microcirculation are essential for maintaining liver health,which is influenced by sex and genetic background.Understanding these variations is crucial for add... BACKGROUND The integrity and functionality of the hepatic microcirculation are essential for maintaining liver health,which is influenced by sex and genetic background.Understanding these variations is crucial for addressing disparities in liver disease outcomes.AIM To investigate the sexual dimorphism and genetic heterogeneity of liver microcirculatory function in mice.METHODS We assessed hepatic microhemodynamics in BALB/c,C57BL/6J,and KM mouse strains using laser Doppler flowmetry and wavelet analysis.We analyzed the serum levels of alanine transaminase,glutamic acid aminotransferase,total bile acid,total protein,alkaline phosphatase,and glucose.Histological and immunohistochemical staining were employed to quantify microvascular density and the expression levels of cluster of differentiation(CD)31,and estrogen receptorα,andβ.Statistical analyses,including the Mantel test and Pearson correlation,were conducted to determine the relationships among hepatic function,microcirculation,and marcocirculation between different sexes and across genetic backgrounds.RESULTS We identified sex-based disparities in hepatic microhemodynamics across all strains,with males exhibiting higher microvascular perfusion and erythrocyte concentration,but lower blood velocity.Strain-specific differences were evident,particularly in the endothelial oscillatory characteristics of the erythrocyte concentration.No sexdependent differences in estrogen receptor expression were observed,while significant variations in CD31 expression and microvascular density were observed.The correlations highlighted relationships between hepatic microhemodynamics and liver function indicators.CONCLUSION Our findings indicate the influence of genetic and sex differences on hepatic microcirculation and liver function,highlighting the necessity of incorporating both genetic background and sex into hepatic physiology studies and potential liver disease management strategies. 展开更多
关键词 Hepatic microhemodynamics Sex differences Mouse strains Biological oscillators Hepatic microcirculation
暂未订购 下载PDF
Optimizing the traffic microcirculation in old neighborhood based on the bi-level multi-objective model 认领 引用
6
作者 Yuanyuan Guo Xinyue Ye +1 位作者 Ke Huang Xinyi Liu 《Digital Transportation and Safety》 2025年第4期227-241,共15页
Urban traffic congestion has become increasingly severe,along with the rapid progress of urbanization and motorization worldwide,particularly in the areas with old neighborhoods.These areas often face issues such as t... Urban traffic congestion has become increasingly severe,along with the rapid progress of urbanization and motorization worldwide,particularly in the areas with old neighborhoods.These areas often face issues such as the slow speed of vehicles and difficulties in parking due to the incomplete traffic microcirculation system.This paper focuses on optimizing traffic microcirculation in the areas of old neighborhoods through scenario simulations.The bi-level optimization model for the traffic microcirculation system,which considers intersection delays,was developed and solved by using a genetic algorithm to devise an optimal road network strategy.By taking the case of Zhuangwangfu,an old neighborhood of Tianjin,China,we validated the optimization model.The results indicate that measures such as converting some two-way streets to one-way,widening roads,and increasing the number of minor roads can effectively reduce the saturation of main roads.These efforts can also improve the utilization of minor roads,balance traffic volumes between main and minor roads,and significantly alleviate traffic congestion in old neighborhoods.These results can also provide valuable insights for alleviating traffic congestion through traffic microcirculation,thus improving the urban environment. 展开更多
关键词 Traffic microcirculation Old neighborhoods Bi-level optimization model Traffic congestion Urban renewal
暂未订购 下载PDF
Bivalirudin for anticoagulation in elderly acute coronary syndrome:Effects on myocardial microcirculation and adverse events 认领 引用
7
作者 Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng 《World Journal of Clinical Cases》 2025年第13期47-51,共5页
The management of acute coronary syndrome(ACS)in older patients remains challenging because standard anticoagulants often fail to yield optimal outcomes.Bivalirudin,a direct inhibitor of thrombin,serves as an alternat... The management of acute coronary syndrome(ACS)in older patients remains challenging because standard anticoagulants often fail to yield optimal outcomes.Bivalirudin,a direct inhibitor of thrombin,serves as an alternative to traditional therapies.This drug is particularly effective in enhancing myocardial microcircu-lation and reducing adverse events after clinical interventions.The present article explores the findings of a recent study that highlighted the clinical benefits of bivalirudin by investigating its effects on myocardial microcirculation and adverse cardiac events after percutaneous coronary intervention in older patients with ACS.Compared with unfractionated heparin,bivalirudin markedly reduced the emergency response time and improved cardiac function indicators.It further mitigated the risks of cardiovascular events and recurrent myocardial infarctions.These findings suggest that bivalirudin can enhance myocardial perfusion and reduce bleeding complications,thus serving as a safe,effective anticoagulation agent for older patients with ACS.Nonetheless,further large-scale,high-quality trials are needed to establish optimal usage guidelines and assess long-term outcomes.Integrating bivalirudin into ACS treatment protocols for older patients may help optimize patient care,balancing efficacy and safety.Continual research and consensus building are necessary for the widespread clinical application of bivalirudin and the improvement of ACS outcomes in older patients. 展开更多
关键词 Bivalirudin Acute coronary syndrome Myocardial microcirculation Elderly patients Anticoagulation
暂未订购 下载PDF
Artificial intelligence based real-time microcirculation analysis system for laparoscopic colorectal surgery 认领 引用 被引量：20
8
作者 Sang-Ho Park Hee-Min Park +3 位作者 Kwang-Ryul Baek Hong-Min Ahn In Young Lee Gyung Mo Son 《World Journal of Gastroenterology》 SCIE CAS 2020年第44期6945-6962,共18页
BACKGROUND Colonic perfusion status can be assessed easily by indocyanine green(ICG)angiography to predict ischemia related anastomotic complications during laparoscopic colorectal surgery.Recently,various parameter-b... BACKGROUND Colonic perfusion status can be assessed easily by indocyanine green(ICG)angiography to predict ischemia related anastomotic complications during laparoscopic colorectal surgery.Recently,various parameter-based perfusion analysis have been studied for quantitative evaluation,but the analysis results differ depending on the use of quantitative parameters due to differences in vascular anatomical structure.Therefore,it can help improve the accuracy and consistency by artificial intelligence(AI)based real-time analysis microperfusion(AIRAM).AIM To evaluate the feasibility of AIRAM to predict the risk of anastomotic complication in the patient with laparoscopic colorectal cancer surgery.METHODS The ICG curve was extracted from the region of interest(ROI)set in the ICG fluorescence video of the laparoscopic colorectal surgery.Pre-processing was performed to reduce AI performance degradation caused by external environment such as background,light source reflection,and camera shaking using MATLAB 2019 on an I7-8700k Intel central processing unit(CPU)PC.AI learning and evaluation were performed by dividing into a training patient group(n=50)and a test patient group(n=15).Training ICG curve data sets were classified and machine learned into 25 ICG curve patterns using a self-organizing map(SOM)network.The predictive reliability of anastomotic complications in a trained SOM network is verified using test set.RESULTS AI-based risk and the conventional quantitative parameters including T1/2max,time ratio(TR),and rising slope(RS)were consistent when colonic perfusion was favorable as steep increasing ICG curve pattern.When the ICG graph pattern showed stepped rise,the accuracy of conventional quantitative parameters decreased,but the AI-based classification maintained accuracy consistently.The receiver operating characteristic curves for conventional parameters and AI-based classification were comparable for predicting the anastomotic complication risks.Statistical performance verifications were improved in the AI-based analysis.AI analysis was evaluated as the most accurate parameter to predict the risk of anastomotic complications.The F1 score of the AI-based method increased by 31% for T1/2max,8% for TR,and 8% for RS.The processing time of AIRAM was measured as 48.03 s,which was suitable for real-time processing.CONCLUSION In conclusion,AI-based real-time microcirculation analysis had more accurate and consistent performance than the conventional parameter-based method. 展开更多
关键词 Indocyanine green Laparoscopic Artificial intelligent Anastomotic complications Colorectal surgery Microcirculation analysis
暂未订购 下载PDF
Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation 认领 引用 被引量：10
9
作者 Liu Yang Zhong-Yang Shen +5 位作者 Rao-Rao Wang Ming-Li Yin Wei-Ping Zheng Bin Wu Tao Liu Hong-Li Song 《World Journal of Gastroenterology》 SCIE CAS 2017年第19期3449-3467,共19页
AIM To investigate the effects of heme oxygenase-1(HO-1)-modified bone marrow mesenchymal stem cells(BMMSCs)on the microcirculation and energy metabolism of hepatic sinusoids following reduced-size liver transplantati... AIM To investigate the effects of heme oxygenase-1(HO-1)-modified bone marrow mesenchymal stem cells(BMMSCs)on the microcirculation and energy metabolism of hepatic sinusoids following reduced-size liver transplantation(RLT)in a rat model.METHODS BMMSCs were isolated and cultured in vitro using an adherent method,and then transduced with HO-1-bearing recombinant adenovirus to construct HO-1/BMMSCs.A rat acute rejection model following 50%RLT was established using a two-cuff technique.Recipients were divided into three groups based on the treatment received:normal saline(NS),BMMSCs and HO-1/BMMSCs.Liver function was examined at six time points.The levels of endothelin-1(ET-1),endothelial nitric-oxide synthase(e NOS),inducible nitric-oxide synthase(i NOS),nitric oxide(NO),and hyaluronic acid(HA)were detected using an enzyme-linked immunosorbent assay.The portal vein pressure(PVP)was detected by Power Lab ML880.The expressions of ET-1,i NOS,e NOS,and von Willebrand factor(v WF)protein in the transplanted liver were detected using immunohistochemistry and Western blotting.ATPase in the transplanted liver was detected by chemical colorimetry,and the ultrastructural changes were observed under a transmission electron microscope.RESULTS HO-1/BMMSCs could alleviate the pathological changes and rejection activity index of the transplanted liver,and improve the liver function of rats following 50%RLT,with statistically significant differences compared with those of the NS group and BMMSCs group(P<0.05).In term of the microcirculation of hepatic sinusoids:The PVP on POD7 decreased significantly in the HO-1/BMMSCs and BMMSCs groups compared with that of the NS group(P<0.01);HO-1/BMMSCs could inhibit the expressions of ET-1 and i NOS,increase the expressions of e NOS and inhibit amounts of NO production,and maintain the equilibrium of ET-1/NO(P<0.05);and HO-1/BMMSCs increased the expression of v WF in hepatic sinusoidal endothelial cells(SECs),and promoted the degradation of HA,compared with those of the NS group and BMMSCs group(P<0.05).In term of the energy metabolism of the transplanted liver,HO-1/BMMSCs repaired the damaged mitochondria,and improved the activity of mitochondrial aspartate aminotransferase(ASTm)and ATPase,compared with the other two groups(P<0.05).CONCLUSION HO-1/BMMSCs can improve the microcirculation of hepatic sinusoids significantly,and recover the energy metabolism of damaged hepatocytes in rats following RLT,thus protecting the transplanted liver. 展开更多
关键词 Reduced-size liver transplantation Bone marrow mesenchymal stem cells Microcirculation Heme oxygenase-1 Energy metabolism
暂未订购 下载PDF
Intestinal microcirculation dysfunction in sepsis: pathophysiology, clinical monitoring, and therapeutic interventions 认领 引用 被引量：22
10
作者 A-ling Tang Mei-jia Shen Guo-qiang Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2022年第5期343-348,共6页
BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of sepsis.DATA RE... BACKGROUND:Intestinal microcirculation dysfunction is an important factor that causes poor prognosis in sepsis patients and is an important pathophysiological basis for the occurrence and development of sepsis.DATA RESOURCES:PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched from inception to August 1,2021.The search was limited to the English language only.Two reviewers independently identified studies related to intestinal microcirculation dysfunction in sepsis.Exclusion criteria were duplicate articles according to multiple search criteria.RESULTS:Fifty articles were included,and most of them were animal studies.These studies reported pathogenesis,including endothelial dysfunction,leukocyte recruitment and adhesion,microthrombus formation,microcirculation hypoperfusion,and redistribution of intestinal wall blood flow.The monitoring methods of intestinal microcirculation were also diverse,including handheld microscopes,intravital microscopy(IVM),laser Doppler blood flow instruments,laser speckle contrast imaging,tissue refl ectance spectrophotometry,biochemical markers of intestinal ischemia,and histopathological examination.In view of the related pathogenesis of intestinal microcirculation disorder in sepsis,existing studies also have diff erent opinions on its treatment.CONCLUSIONS:Limited by monitoring,there are few clinical studies on intestinal microcirculation dysfunction in sepsis.Related research mainly focuses on basic research,but some progress has also been made.Therefore,this review may provide a reference for future research on intestinal microcirculation dysfunction in sepsis. 展开更多
关键词 Sepsis Microcirculation Intestinal barrier Intestinal ischemia Review
暂未订购 下载PDF
Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis 认领 引用 被引量：11
11
作者 Sasa-Marcel Maksan Eduard Ryschich +2 位作者 Zilfi ¨)lger Martha Maria Gebhard Jan Schmidt 《World Journal of Gastroenterology》 SCIE CAS 2005年第6期846-849,共4页
AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver cirrhosis.METHODS: Hepatic cirrhosis was induced in Wistar rats by gavage with car... AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver cirrhosis.METHODS: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal hypertension.RESULTS: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood flow.CONCLUSION: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin Ⅲ levels and could be responsible for disturbances of organ pathology. 展开更多
关键词 Liver cirrhosis Microcirculation Small intestine Liver
暂未订购 下载PDF
In vivo observation of cerebral microcirculation after experimental subarachnoid hemorrhage in mice 认领 引用 被引量：4
12
作者 Xiao-mei Yang Xu-hao Chen +3 位作者 Jian-fei Lu Chang-man Zhou Jing-yan Han Chun-hua Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第3期456-462,共7页
Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previou... Acute brain injury caused by subarachnoid hemorrhage is the major cause of poor prognosis. The pathology of subarachnoid hemorrhage likely involves major morphological changes in the microcirculation. However, previous studies primarily used fixed tissue or delayed injury models. Therefore, in the present study, we used in vivo imaging to observe the dynamic changes in cerebral microcirculation after subarachnoid hemorrhage. Subarachnoid hemorrhage was induced by perforation of the bifurcation of the middle cerebral and anterior cerebral arteries in male C57/BL6 mice. The diameter of pial arterioles and venules was measured by in vivo fluorescence microscopy at different time points within 180 minutes after subarachnoid hemorrhage. Cerebral blood flow was examined and leukocyte adhesion/albumin extravasation was determined at different time points before and after subarachnoid hemorrhage. Cerebral pial microcirculation was abnormal and cerebral blood flow was reduced after subarachnoid hemorrhage. Acute vasoconstriction occurred predominantly in the arterioles instead of the venules. A progressive increase in the number of adherent leukocytes in venules and substantial albumin extravasation were observed between 10 and 180 minutes after subarachnoid hemorrhage. These results show that major changes in microcirculation occur in the early stage of subarachnoid hemorrhage. Our findings may promote the development of novel therapeutic strategies for the early treatment of subarachnoid hemorrhage. 展开更多
关键词 nerve regeneration subarachnoid hemorrhage microcirculation disturbance leukocyte adhesion albumin extravasation cerebral blood flow vasoconstriction early brain injury neural regeneration
暂未订购 下载PDF
The effect of SphK1/S1P signaling pathway on hepatic sinus microcirculation in rats with hepatic ischemia-reperfusion injury 认领 引用 被引量：5
13
作者 Li-Ming Jin Yuan-Xing Liu +7 位作者 Jian Cheng Lin Zhou Hai-Yang Xie Xiao-Wen Feng Hui Li Yan Shen Xiao Xu Shu-Sen Zheng 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2022年第1期94-98,共5页
To the Editor:Hepatic ischemia-reperfusion(I/R)injury is the component of liver injury related to liver transplantation and liver surgery[1-3].The hepatic sinus microcirculation injury is a central part of hep-atic I/... To the Editor:Hepatic ischemia-reperfusion(I/R)injury is the component of liver injury related to liver transplantation and liver surgery[1-3].The hepatic sinus microcirculation injury is a central part of hep-atic I/R injury,which eventually leads to hepatocyte injury.This process is closely associated with the participation of liver non-parenchymal cells such as Kuffer cells,hepatic stellate cells,liver sinusoidal endothelial cells(LSECs),and cytokines. 展开更多
关键词 hepatic ischemia microcirculation
暂未订购 下载PDF
In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT 认领 引用 被引量：6
14
作者 Shaozhuang Yang Liwei Liu +7 位作者 Yixin Chang Ningning Zhang Kun Liu Liang Hong Bingling Chen Yue Zhao Rui Hu Junle Qu 《Journal of Innovative Optical Health Sciences》 SCIE EI 2019年第1期62-71,共10页
In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain microcirculation.We used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs... In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain microcirculation.We used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels.Owing to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 min.Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring. 展开更多
关键词 Optical coherence tomography brain microcirculation cerebral blood vessels gold nanorods
暂未订购 下载PDF
Effect of moxibustion on the nailfold microcirculation of young and middle-aged people in sub-health status 认领 引用 被引量：4
15
作者 田岳凤 翟春涛 +2 位作者 高海宁 陈猛 王军 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2017年第4期1-7,共7页
Objective To explore the mechanism of moxibustion for people in sub-health status. Methods Thirty-nine young and middle-aged sub-health volunteers were enrolled, including 13 males and 26 females. Mild moxibustion was... Objective To explore the mechanism of moxibustion for people in sub-health status. Methods Thirty-nine young and middle-aged sub-health volunteers were enrolled, including 13 males and 26 females. Mild moxibustion was adopted, and Shenque （神阙 CV 8）, Guanyuan （关元 CV 4）, Zusanli （足三里 ST 36, bilateral）, Pish0 （脾俞 BL 20, bilateral） and Shenshu （肾俞 BL 23, bilateral） were selected. The moxibustion was performed once every other day, 20 min at each time, and moxibustion for ten times was needed. The changes in morphology, flow velocity and pefiloop of nailfold microcirculation were detected by adopting microcirculation detector before moxibustion, after moxibustion for three times, six times, ten times, and on the 15th day after moxibustion, respectively. Results After moxibustion, the abnormal blood capillary morphology of microcirculation gradually turned into normal pattern along with the increase of the number of times of moxibustion, according to the comparison of the number of capillary loop, the diameter of input limb, the diameter of output limbhe diameter of input limb, flow pattern integral, pefiloop integral and total integral with those before moxibustion, the differences were all statistically significant （all P〈0.01）. Conclusion Moxibustion changs the microcirculation of nailfold of body, improves the blood flow pattern, makes the pefiloop status clear, accelerats the blood flow and increases the microcirculation perfusion amount, thus regulating the sub- health status of human body. 展开更多
关键词 Mild moxibustion sub-health nail fold microcirculation
暂未订购 下载PDF
Dynamic changes in cerebral microcirculation and hypoxia in the early stages of diffuse axonal injury 认领 引用 被引量：5
16
作者 Jinning Song Xiaobin Liu +2 位作者 Jingyu Chen Fenru Zhang Lei Xi 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第20期1530-1536,共7页
This study demonstrated that damage to the cerebral microvasculature, the formation of microthrombi and swelling of vascular endothelial cells occur early and peak 12 hours after injury in a rat model of diffuse axona... This study demonstrated that damage to the cerebral microvasculature, the formation of microthrombi and swelling of vascular endothelial cells occur early and peak 12 hours after injury in a rat model of diffuse axonal injury. Moreover, these pathological changes were most evident in the cerebral cortex. Cerebral microcirculatory dysfunction peaked later and had a shorter duration than axonal injury. In addition, the radioactive imaging agent, 99Tcm-4, 9-diaza-2, 3, 10, 10- tetramethyldodecan-2, 11 -dione dioxime, was used to visualize the dynamic changes that occur in tissue with cerebral hypoxia. The results demonstrated that cerebral hypoxia occurs at an early stage in diffuse axonal injury. Cerebral hypoxia was evident 12 hours after injury and declined slightly 24 hours after injury, but was significantly higher than in the control group. The pathological changes that underpin microcirculatory dysfunction did not occur at the same time as axonal injury, but did occur simultaneously with neuronal injury. Cerebral hypoxia plays a key role in promoting the secondary brain injury that occurs after diffuse axonal injury. 展开更多
关键词 diffuse axonal injury microcirculation hypoxia 99Tcm-4, 9-diaza-2, 3, 10, 10- tetramethyldodecan-2, 11-dione dioxime radioactive counting brain injury neural regeneration
暂未订购 下载PDF
Expression of platelet endothelial cell adhesion molecule-1 between pancreatic microcirculation and peripheral circulation in rats with acute edematous pancreatitis 认领 引用 被引量：5
17
作者 Hong-Kai Gao Zong-Guang Zhou +2 位作者 You-Qin Chen Fang-Hai Han Cun Wang the Department of General Surgery and Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China 《Hepatobiliary & Pancreatic Diseases International》 CAS 2003年第3期463-466,共4页
OBJECTIVE: To study the ehanges of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation anti pancreatic microcirculation in rats with acut... OBJECTIVE: To study the ehanges of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation anti pancreatic microcirculation in rats with acute edematous pancreatitis (AEP). METHODS: The model of AEP was established with 50 Wistar rats, and the changes of PECAM-1 expression on PMNs from the splenic vein and inferior vena cava were determined by flow cytometry. RESULTS: PECAM-I expression on PMNs showed no significant difference between pancreatic microcirculation and peripheral circulation at AEP2h and AEP4h time points. From the AEP4h to the AEP8h time point, PECAM-1 expression in peripheral circulation was up-regulated, but PECAM-1 expression in pancreatic microcirculation was down-regulated. PECAM-1 expression had a significant difference between pancreatic microcirculation and peripheral circulation at the AEP8h time point (P<0.05). CONCLUSION: PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculation and peripheral circulation in AEP. 展开更多
关键词 acute edematous pancreatitis peripheral circulation pancretic microcirculation polymorphonuclear leukocyte platelet endothelial cell adhesion molecules-1
暂未订购 下载PDF
Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway 认领 引用 被引量：3
18
作者 A-ling Tang Yan Li +4 位作者 Li-chao Sun Xiao-yu Liu Nan Gao Sheng-tao Yan Guo-qiang Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第3期206-213,共8页
BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.METHODS:A rat model of sepsis was established by cecal ligation and puncture... BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its mechanism.METHODS:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ group.XBJ was intraperitoneally injected 2 h before CLP.Hemodynamic data(blood pressure and heart rate) were recorded.The intestinal microcirculation data of the rats were analyzed via microcirculation imaging.Enzyme-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the rats.Histological analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in rats.The expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western blotting.RESULTS:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory response.Moreover,XBJ upregulated the expression of VEGF-A,p-PI3Kotal PI3K,and p-Aktotal Akt in the rat small intestine.CONCLUSION:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway. 展开更多
关键词 Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B
暂未订购 下载PDF
EFFECTS OF ELECTRO ACUPUNCTURE AT NEIGUAN ON MYOCARDIAL MICROCIRCULATION IN RABBITS WITH ACUTE MYOCARDIAL ISCHEMIA 认领 引用 被引量：5
19
作者 曹庆淑 刘俊岭 +1 位作者 陈淑萍 韩振京 《Journal of Traditional Chinese Medicine》 1998年第2期134-139,共6页
This paper reports the effects of electroacupuncture (EA) at Neiguan (P 6) on myocardial microcirculation and electrical activity observed in rabbits with acute myocardial ischemia (AMI) by employing the vascular cast... This paper reports the effects of electroacupuncture (EA) at Neiguan (P 6) on myocardial microcirculation and electrical activity observed in rabbits with acute myocardial ischemia (AMI) by employing the vascular casting method and taking monophasic action potential (MAP) as an index. It was found that in the ischemic border zone of the heart, the electrical excitability was strengthened, the shortening of the phase repolarization inhibited, and the number of the micrangia increased in some degree following EA. This suggests that EA can relieve arteriolospasm, inhibit extreme dilatation of blood capillaries, modulate imbalance of micro-vasomotion of the coronary artery, improve myocardial blood-supply, and promote normalization of electrical activities of the ischemia myocardium. This fact not only elucidates the recovery mechanism of the ischemic myocardium promoted by EA at Neiguan (P 6), but also provides morphological basis for the theory of relationship between Neiguan of the Pericardium Meridian and the heart. 展开更多
关键词 Electroacupuncture Action Potentials Acupuncture Points Animals Coronary Vessels Female Heart Male Microcirculation Myocardial Ischemia Rabbits Random Allocation
暂未订购 下载PDF
Deteriorated function of cutaneous microcirculation in chronic congestive heart failure 认领 引用 被引量：5
20
作者 Marie-Louise Edvinsson Erik Uddman Sven E Andersson 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2011年第2期82-87,共6页
Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation.We have previously shown that vascular reactivity is reduced with increasing age.In this ... Background Chronic congestive heart failure is a complex condition that leads to dysfunction in the peripheral microcirculation.We have previously shown that vascular reactivity is reduced with increasing age.In this study,we examined a group of very old patients with severe chronic heart failure to test the hypothesis that vascular function is further compromised by a combination of heart failure and aging.Methods Cutaneous forearm blood flow was measured by laser Doppler flowmetry and compared among three groups:Group 1(n=20,mean±SE:85.5±4 years),heart failure patients with New York Heart Association classⅣ(NYHAⅣ)and with a NT-proBNP level≥5000 ng/L;Group 2(n=15,mean±SE:76.5±2 years),heart failure patients with NYHA II and NT-proBNP≤2000 ng/L,and Group 3(n=10,mean±SE:67.6±3.0 years),healthy controls with no clinical signs of heart failure.The vasodilator response to the iontophoretic administration of acetylcholine(ACh),acting via an endothelial mechanism,and sodium nitroprusside(SNP),acting via a smooth muscle cell mechanism,were studied.Results All patients with heart failure had significantly reduced vascular reactivity independent of the mode of stimulation(ACh,SNP or heat)when compared to healthy controls.However,the responses did not differ between the two groups of heart failure patients.Conclusions Cutaneous vascular reactivity is reduced in heart failure patients and does not correlate with the severity of the condition or age of patients. 展开更多
关键词 heart failure cutaneous microcirculation endothelial responses acetylcholine smooth muscle responses
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 10 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈