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Microfluidic Construction of Glioma Micromodels on Hydrogel Microspheres for Drug Testing 认领 引用
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作者 Yingrui Zhang Zengnan Wu +7 位作者 Jingyang Li Shiyu Chen Tong Xu Shulang Chen Xiaorui Wang Yanli Guo Yi Zhang Jin-Ming Lin 《Engineering》 SCIE EI CSCD 2026年第6期421-429,共9页
Gliomas are aggressive brain tumors associated with poor prognosis,necessitating advanced in vitro models for efficient drug screening.In this study,we develop a microfluidic glioma-on-a-microsphere model based on com... Gliomas are aggressive brain tumors associated with poor prognosis,necessitating advanced in vitro models for efficient drug screening.In this study,we develop a microfluidic glioma-on-a-microsphere model based on compartmentalized hydrogel microspheres with engineered rough surfaces.Each micro-sphere enables to accurately structure U251 glioma cells,M2-polarized THP-1 macrophages,and endothelial cells that can form a functional endothelial barrier on the Matrigel-modified microsphere sur-face.The model exhibited high cell viability,controllable molecular permeability,and upregulated expression of glioma-associated genes compared to conventional two-dimensional(2D)cultures.To val-idate the practicality of this platform in drug evaluation,chlorogenic acid was applied,resulting in sup-pressed gene expression,repolarization of macrophages toward an M1 phenotype,and significant alterations in key metabolites including tryptophan,glutamate,and lactate.Overall,this hydrogel microsphere-based glioma model offers a high-throughput and physiologically relevant platform for drug screening,disease modeling,and personalized therapeutic development. 展开更多
关键词 Microfluidic Glioma-on-a-microsphere Hydrogel microsphere Glioma Drug testing
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Pharmacokinetics,efficacy,and safety of a novel aripiprazole microsphere-based long-acting injectable formulation for schizophrenia:A multicenter,randomized controlled trial 认领 引用
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作者 An-Ning Li Sheng-Chun Jin +14 位作者 De-Wei Shang Jian-Xiong Guo Hua-Li Lin Ming Zhang Bo Wei Feng Wan Yun-Long Tan Li-Li Wang Jian-Chu Zhou Ping Liu Lian-Lian Fan Ju-Shui Sun Bin Chen Yimin Cui Gang Wang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期305-308,共4页
Schizophrenia is a severe and chronic psychiatric disorder with a lifetime prevalence of approximately 0.7%–1%worldwide[1].Aripiprazole is widely used for schizophrenia treatment,and known as a dopamine system stabil... Schizophrenia is a severe and chronic psychiatric disorder with a lifetime prevalence of approximately 0.7%–1%worldwide[1].Aripiprazole is widely used for schizophrenia treatment,and known as a dopamine system stabilizer due to its partial agonist activity as the dopamine-2(D2)and serotonin 5-hydroxytryptamine 1A(5-HT1A)receptors,as well as antagonist action at the 5-HT2A receptors[2].The investigational microsphere-based aripiprazole injection in this study is a novel long-acting formulation designed to optimize the release profile at the dose of 350 mg monthly.The objective of this study was to evaluate the pharmacokinetics,efficacy,and safety of the microsphere-based formulation,particularly the fluctuations in the peak-to-trough plasma concentration ratio. 展开更多
关键词 psychiatric disorder schizophrenia long acting injectable pharmacokinetics safety aripiprazole efficacy microsphere based
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Double-Hollow Porous Heterostructured CoP/Cu3P Microspheres for High-Performance Asymmetric Supercapacitors 认领 引用
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作者 Gaoliang Wang Pu Hu +6 位作者 Weifeng Liu Tao Jiang Yamin Feng Zhuang Ma Liangming Zheng Chaoqun Shang Junmin Nan 《Rare Metals》 SCIE EI CAS CSCD 2026年第2期669-679,共11页
CoP has become a research hotspot for supercapacitor electrode materials because of its considerable theoretical capacitance and metalloid nature,but its commercial application remains hampered by structural instabili... CoP has become a research hotspot for supercapacitor electrode materials because of its considerable theoretical capacitance and metalloid nature,but its commercial application remains hampered by structural instability and sluggish ion kinetics.Herein,a high-performance double-hollow porous heterostructured CoP/Cu3P microsphere is assembled using a hydrothermal reaction and phosphating process.The collaborative interaction between the heterostructure and double-hollow microsphere leads to a suppression of volume change,expansion of the active surface,and ion diffusion.The developed CoP/Cu3P sample demonstrates a specific capacitance of 1172.4 F g-1 at 1.0 A g-1 along with outstanding rate capability (capacitance retains 58.5% of its value as current density increases by 20 times),and cycling stability (i.e.,10,000 cycles,90.0% of its original capacitance).Post-cycling analysis shows minimal morphological change,validating the structural robustness of the CoP/Cu3P microspheres.Furthermore,operating at a high voltage of 1.6 V,the asymmetric CoP/Cu3P supercapacitor demonstrates remarkable energy density (44.1 Wh kg-1) and power density (846.8 W kg-1) while maintaining 84.7% of the maximum capacity even after 20,000 cycles,highlighting its exceptional performance.The influence of the electrochemical performance is further verified through first-principles calculations and indicates the promising application prospects in electrical energy storage. 展开更多
关键词 asymmetric supercapacitor CoP/Cu3P double-hollow microsphere electrical energy storage heterostructure
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Study on Hyaluronic Acid-g-Lipoic Acid Microsphere-based Injectable Hydrogel for Treating Early Knee Osteoarthritis 认领 引用
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作者 Mu-Zhi Zhang Jia-Tian Qian +6 位作者 Da-Wei Niu Yan-Cheng Chen Shi-Ao Li Jiu-Jiang Zeng Kun-Xi Zhang Yan-Li Song Pei-Liang Fu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第2期450-464,I0013,共15页
Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injecti... Early knee osteoarthritis(KOA)is characterized by progressive degeneration of the articular cartilage,synovial inflammation,and excessive accumulation of reactive oxygen species(ROS).At present,intra-articular injection of hyaluronic acid(HA)is widely used to alleviate symptoms;however,its lubrication persistence,antioxidant,and anti-inflammatory abilities are limited,and it is difficult to effectively delay the early process of cartilage degeneration.Based on this,hyaluronic acid-g-lipoic acid(HA-LA)was synthesized by esterification reaction,and HA-LA microspheres were prepared by a reversed-phase emulsion method,which was combined with a macromolecular HA-LA solution to form injectable hydrogels.The objective of this study was to evaluate the efficacy of an injectable hydrogel based on hyaluronic acid-g-lipoic acid microspheres(HA-LA MS)for the treatment of KOA and to verify its injectability,lubricity,reactive oxygen species(ROS)scavenging ability,and anti-inflammatory effects.The results show that the HA-LA MS hydrogel has excellent shear thinning characteristics and continuous injectability,and its microsphere structure significantly reduces the interfacial friction coefficient through the rolling effect.In vitro experiments have shown that the hydrogel can efficiently scavenge ROS,reduce the expression of inflammatory factors,and is non-cytotoxic.The HA-LA MS injectable hydrogel has excellent lubricity,ROS scavenging ability,and anti-inflammatory effects in vivo,which can effectively delay the degeneration of early KOA cartilage,and its efficacy is significantly better than that of traditional hyaluronic acid,making it a promising intra-articular injection preparation. 展开更多
关键词 Knee osteoarthritis Hyaluronic acid Microsphere hydrogel Injectable Antioxidant Lubricity
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Zn dilution-directed synthesis of Pt nanoclusters on porous nickel-carbon microspheres for hydrogen evolution 认领 引用
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作者 Hui Liu Rong Lin +7 位作者 Yuting Fu Xuanxuan Lin Zhihao Huang Nan Li Haoran Wang Xusheng Wang Qipeng Li Jinjie Qian 《Science China Materials》 SCIE EI CAS CSCD 2026年第7期3990-3998,共9页
The development of low platinum-loading catalysts for the economically viable hydrogen evolution reaction(HER)remains challenging.Herein,a precursor dilution strategy is used to fabricate Pt nanoclusters anchored on N... The development of low platinum-loading catalysts for the economically viable hydrogen evolution reaction(HER)remains challenging.Herein,a precursor dilution strategy is used to fabricate Pt nanoclusters anchored on Ni-embedded porous carbon microspheres.The approach begins with the facile synthesis of Zn/Ni-based coordination polymers(Ni-BTC-Zn)due to the isomorphic substitution of Zn2+and Ni2+.During pyrolysis,the evaporation of zinc species results in a highly porous carbon structure with well-dispersed nickel nanoparticles.Subsequent solvothermal treatment allows for the uniform deposition of Pt nanoclusters to form the final bimetallic PtNi catalysts(PtNi-BTC-C).Among them,the optimized PtNi-BTC-C10 exhibits exceptional alkaline HER performance,requiring an overpotential of only 41 mV to achieve 10 mA cm-2 and a low Tafel slope of 31.1 mV dec-1.It also demonstrates outstanding durability with a current retention of 90.7%after 70 h,far exceeding Pt/C.Extensive characterization confirms that moderate Zn dilution optimally modulates the Ni particle size and dispersion,leading to maximized active sites and enhanced charge transfer.Combined with DFT calculations,the Pt-Ni-cluster model for PtNi-BTC-C10 possesses an optimized electronic structure with a shifted d-band center,which facilitates water dissociation and optimizes H* desorption with the most favorable energetics(0.262 eV).This work provides a fundamental understanding of precursor dilution engineering and offers a versatile pathway for designing advanced noble-metal-based bimetallic electrocatalysts. 展开更多
关键词 Zn dilution Pt nanocluster Ni-C microsphere synergistic effect hydrogen evolution
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Particle-scale mass transfer characteristics of composite microspheres for cesium ion adsorption in nuclear wastewater within microchannel adsorbers 认领 引用
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作者 Hongjing Dai Ziyi Bo +2 位作者 Sifang Wang Shengyang Tao Xuehu Ma 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第1期70-82,共13页
To efficiently remove radioactive nuclides from nuclear industry wastewater and minimize the generation of radioactive secondary waste,this study proposes the concept of a magnetically controlled microchannel adsorber... To efficiently remove radioactive nuclides from nuclear industry wastewater and minimize the generation of radioactive secondary waste,this study proposes the concept of a magnetically controlled microchannel adsorber based on magnetic adsorbents.A novel protocol for achieving high adsorption performance in microchannel adsorbers with periodically distributed particles is developed using the particle-resolved computational fluid dynamics (CFD) method,which addresses the limitations of traditional porous media flow models.To align simulation results more closely with practical scenarios,a typical high-efficiency magnetic adsorbent,magnetic sodium alginate/cobalt-based Prussian blue (M-SA/PB-Co),was synthesized.The M-SA/PB-Co microspheres exhibit a uniform size distribution (300–600 μm),and their Cs+ adsorption follows the pseudo-second-order kinetic model with a Langmuir saturated adsorption capacity of 124.84 mg·g-1.The performance parameters of M-SA/PB-Co,obtained from characterization and adsorption experiments,were integrated into CFD simulations.CFD results indicate that as the flow velocity increases,the flow field gradually transitions with vortices expanding in scale and streamline bifurcation points shifting rearward.The Cs+ concentration decreases progressively along the flow direction,with a more pronounced reduction in the vortex regions downstream of particles.The characteristic velocity and characteristic concentration of specific regions surrounding the particles were extracted based on boundary layer distribution.The amount of concentration reduction of Cs+ through particle is positively correlated with the characteristic concentration and negatively correlated with the characteristic velocity.The number of microspheres required in the microchannel adsorber was optimized using the response surface method.Compared with industrial fixed-bed adsorbers,microchannel adsorbers exhibit 8–10 times higher processing capacity,demonstrating significant industrial application potential. 展开更多
关键词 Microspheres Microchannel Adsorption CFD Nuclear wastewater
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Fabrication of composite microspheres doped with nano-aluminum powder using melt spray technology 认领 引用
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作者 Yilin Liu Lanqi Zhang +7 位作者 Yulong Yin Nan Li Xiangnan Chu Qi Ma Jing Liu Wenbo Yang Yingdi Lv Shengyang Tao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2026年第2期283-292,共10页
Melt spray technology serves as an effective method for fabricating spherical micro-nano composite materials,with established applications in catalysts and pharmaceuticals.This study extends its application to energet... Melt spray technology serves as an effective method for fabricating spherical micro-nano composite materials,with established applications in catalysts and pharmaceuticals.This study extends its application to energetic composite microspheres,investigating the microsphere formation process using nano-aluminum powder(nano-Al)combined with the inert surrogate sucrose octaacetate(SOA).This study systematically investigates the effects of process parameters,formulation composition,and storage conditions on the particle size,morphology,and stability of SOA/Al composite microspheres.Higher atomizing gas pressure and temperature significantly reduced median particle diameter(D50),yielding a D50 of 35.09μm at 150℃ and 200 kPa.The addition of polyethylene glycol:polyvinylpyrrolidone(1:1)enhanced microsphere circularity from 0.67 to 0.85.This system produced 78 g composite microspheres within 20 min,demonstrating efficientlab-scale production.X-ray diffraction and differential scanning calorimetry results indicated that rapid cooling led to amorphous structures,which were stabilized during storage at 4℃.The scalable melt spray fabrication strategy developed here for nanoparticle-doped composite microspheres provides a basis for future studies involving diverse functional composites. 展开更多
关键词 Melt spray Micro-nano composite material Amorphous structure Composite microspheres
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Anxiety,depression,and quality of life in hepatocellular carcinoma treated with drug-eluting microspheres plus lenvatinib:A prospective study 认领 引用
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作者 Jian-Yu Liu Zhi-Hui Liang +3 位作者 Jing-Lei Liu Liang Li Bao Cui Tie-Gang Li 《World Journal of Psychiatry》 SCIE 2026年第4期369-381,共13页
BACKGROUND Patients with hepatocellular carcinoma(HCC)often experience considerable psychological distress that affects their quality of life(QoL).AIM To investigate the effects of drug-eluting microsphere-transcathet... BACKGROUND Patients with hepatocellular carcinoma(HCC)often experience considerable psychological distress that affects their quality of life(QoL).AIM To investigate the effects of drug-eluting microsphere-transcatheter arterial chemoembolization(DEM-TACE)combined with lenvatinib on anxiety,depression,and QoL.METHODS This prospective study enrolled 126 patients with primary HCC treated with DEM-TACE combined with lenvatinib from October 2022 to October 2025.Anxiety and depression assessment with the Hospital Anxiety and Depression Scale(HADS)and QoL evaluation with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30(EORTC QLQC30)and HCC-specific module were conducted at baseline and at 3-,6-,and 12-month.Clinical outcomes,including overall survival,progression-free survival,and adverse events(AEs),were recorded.RESULTS Overall,58.7%and 61.1%of patients exhibited anxiety and depression at baseline,respectively.After treatment,both psychological status and QoL significantly improved.At 12 months,the prevalence rates of anxiety and depression decreased to 31.0%and 28.6%,respectively(both P<0.001).The EORTC QLQ-C30 global health status score increased from 52.3±15.7 to 71.2±14.3(P<0.001).Physical,role,and emotional functioning scores also significantly improved(all P<0.001).Treatment-related AEs were generally manageable.Multivariate analysis showed that baseline HADS score,Barcelona Clinic Liver Cancer stage,and tumor response were independent predictors of QoL outcomes(P<0.05).CONCLUSION DEM-TACE combined with lenvatinib shows an acceptable safety profile and favorable efficacy in improving anxiety,depression,and QoL in patients with HCC.Early psychological assessment and intervention may optimize outcomes. 展开更多
关键词 Anxiety Depression Drug-eluting microspheres Hepatocellular carcinoma Lenvatinib Quality of life
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Uniform Branched Polymer Microspheres via Reversible Addition-fragmentation Chain Transfer Dispersion Self-condensing Vinyl Polymerization 认领 引用
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作者 Chao-Jian Luo Li Zhang Jian-Bo Tan 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第7期2153-2166,共14页
We report a reversible addition-fragmentation chain transfer(RAFT)dispersion self-condensing vinyl polymerization(SCVP)platform using a chain-transfer monomer(CTM)and macro-RAFT agent for the one-pot synthesis of mono... We report a reversible addition-fragmentation chain transfer(RAFT)dispersion self-condensing vinyl polymerization(SCVP)platform using a chain-transfer monomer(CTM)and macro-RAFT agent for the one-pot synthesis of monodisperse microspheres composed of well-defined branched(multi)block copolymers.Under RAFT dispersion polymerization conditions,the CTM functions as both a comonomer and branching RAFT site,affording polymer microspheres containing branched polymers while maintaining narrow particle size distributions.The preserved RAFT end-groups on the branches enabled seeded chain extension to give branched diblock and multiblock copolymer microspheres with methyl methacrylate(MMA)and a range of second monomers,while retaining microsphere monodispersity.Using styrene(St)as the second monomer yielded nanostructured branched PMMA-b-PSt microspheres,whose internal morphologies underwent a sphere-to-cylinder transition as the branching degree in the PMMA block was decreased at a fixed composition.These results establish the branching degree in the branched block as an effective parameter to manipulate intraparticle phase behavior and demonstrate RAFT dispersion SCVP as a scalable route to sequence-controlled,topologically complex polymer microspheres with tunable internal nanostructures. 展开更多
关键词 Reversible addition-fragmentation chain transfer(RAFT)dispersion polymerization Self-condensing vinyl polymerization Polymer microspheres Branched polymers
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Preparation and Catalytic Performance of Hierarchical Porous Polystyrene Microsphere-supported Au NPs Composite Catalyst 认领 引用
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作者 ZHANG Yao ZHANG Jinming +2 位作者 XIONG Yi LI Xuefeng ZHANG Gaowen 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2026年第4期1107-1115,共9页
A hierarchical porous polystyrene microsphere(HPPM)that simultaneously possesses micro-,meso-,and macropores was fabricated by two-step seed swelling and hyper-crosslinking method,respectively,based on the polystyrene... A hierarchical porous polystyrene microsphere(HPPM)that simultaneously possesses micro-,meso-,and macropores was fabricated by two-step seed swelling and hyper-crosslinking method,respectively,based on the polystyrene(PS)microspheres prepared by dispersion polymerization using a shaker.Subsequently,Au NPs were in-situ loaded onto the sulphonated HPPM via a thermal reduction reaction to prepare the hierarchical porous polystyrene microsphere-supported Au NPs(Au@sHPPM)composite catalyst.SEM and particle size test results show that the microspheres exhibit excellent monodispersity.The specific surface area reaches 529.21 m2·g-1when the ratio of St/DVB is 0.6:2.0,and further increases to 644.14 m2·g-1after hyper-crosslinking.The XRD and XPS analysis results indicate that HAuCl4is reduced to Au NPs.In the reduction reaction of 4-nitrophenol with sodium borohydride(NaBH4),Au@sHPPM composite catalyst demonstrates excellent catalytic performance,with a conversion rate of up to 96.76%within 15 minutes.Furthermore,it also demonstrates outstanding catalytic performance for organic dyes such as Congo red,Rhodamine B and Malachite green,indicating that the Au@sHPPM composite catalyst has good stability and reusability. 展开更多
关键词 polystyrene microspheres hierarchical porous shaking table method Au NPs catalytic performance
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Near-field differential scattering algorithm for wavefront control in precise microsphereassisted laser nanofabrication 认领 引用
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作者 Wei Liang Chen Zhao +2 位作者 Zhiwen Gao Zhiyang Xu Yinzhou Yan 《Advanced Photonics Nexus》 CSCD 2026年第4期136-146,共11页
Microsphere arrays exhibit significant potential in large-area laser processing due to their high numerical aperture for near-field nanofocusing and self-assembly properties for scalable deployment.However,the complex... Microsphere arrays exhibit significant potential in large-area laser processing due to their high numerical aperture for near-field nanofocusing and self-assembly properties for scalable deployment.However,the complexity of wavefront-modulated light interaction with microspheres presents significant challenges in predicting and optimizing processing outcomes.Therefore,developing accurate computational models to elucidate and tailor these near-field effects is essential to translate the inherent advantages of microspheres into reliable and efficient nanofabrication processes.This work presents a near-field differential scattering(NFDS)algorithm for high-fidelity and computationally efficient calculation of microsphere-assisted near-field nanofocusing.The algorithm advances conventional Mie scattering theory by incorporating wavefront characteristics and localized near-field corrections.Through comparison with experimental results,the in-plane polarization component is identified as the critical factor determining processing outcomes.Furthermore,the NFDS framework is integrated into a corrective patterning workflow for microsphere arrays,demonstrating its capability to achieve precise positional alignment and tailored morphological control in the fabrication of functional micro-and nanostructures.This work bridges the gap between high-accuracy physical modeling and practical nanofabrication,establishing a scalable computational foundation for wavefrontengineered microsphere photolithography. 展开更多
关键词 microsphere array Mie scattering theory laser processing wavefront control polarization
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Multi-shell bowl-like carbon microspheres for lightweight and broadband microwave absorption 认领 引用 被引量：2
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作者 Yan Cheng Yongzhen Ma +7 位作者 Kai Zhou Zhixin Cai Yanlong Ma Binglong Zheng Huanqin Zhao Hongwei Zhou Haibo Yang Renchao Che 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第17期265-275,共11页
Carbon materials have made significant progress in the field of microwave absorption(MA),but achieving wide effective absorption bandwidth(EAB)at low filler content still remains a great challenge.In this work,we desi... Carbon materials have made significant progress in the field of microwave absorption(MA),but achieving wide effective absorption bandwidth(EAB)at low filler content still remains a great challenge.In this work,we design multi-shell bowl-like mesoporous carbon microspheres(MBMCs)by a facile hard template method for efficient MA.It is demonstrated that the spacing between inner and outer shell and second shell thickness play a vital role on the configuration of carbon microspheres.By controlling the second addition of silica template,the microstructure of carbon microsphere evolves from spherical to bowl shape geometry.Expanded shell spacing is beneficial for forming bowl-like microsphere.The dielectric loss and MA properties are highly associated with the configuration of MBMCs.Well-proportioned MBMCs with appropriate shell spacing present wide EAB of 7.3 GHz under a low filling ratio of 12 wt.%.This work paves a new way to broaden EAB and lower filling content of carbon materials via asymmetric multilayer microstructure design. 展开更多
关键词 Bowl-like Multi-shell Mesoporous Carbon microsphere Microwave absorption
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Porous PLGA microspheres for the inhalation delivery of icariin and miR-23b in the treatment of metastatic lung cancer 认领 引用 被引量：2
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作者 Boyu Xiong Xinxin Shao +3 位作者 Guangxu Fang Mengmeng Dong Haobo Han Quanshun Li 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2025年第2期131-145,共15页
Herein,porous poly(lactic-co-glycolic acid)(PLGA)microspheres were prepared to load icariin andmiR-23b for the treatment of metastatic lung cancer.The microspheres exhibited desirable aerodynamic diameter,high drug lo... Herein,porous poly(lactic-co-glycolic acid)(PLGA)microspheres were prepared to load icariin andmiR-23b for the treatment of metastatic lung cancer.The microspheres exhibited desirable aerodynamic diameter,high drug loading and encapsulation efficiency,as well as a favorable drug release profile,which was beneficial for the deposition and exposure of drugs in the lung tissues.The release solution from microspheres exhibited a favorable anti-proliferative effect by inducting cell apoptosis and arresting the cell cycle at G1 phase,and meanwhile inhibited the migration and invasion of cancer cells.More importantly,the microspheres could be effectively inhaled and accumulated in the lung tissues to trigger the in situ apoptosis of tumor cells and suppress metastasis,using mice bearing melanoma-metastatic lung cancer as a model.Furthermore,inhalation of themicrospheres showed favorable biocompatibility,barely causing tissue damage.Overall,porous PLGA microspheres provide a promising platform for the inhalable co-delivery of drugs and genes to obtain ideal therapeutic efficacy in lung cancer and other pulmonary diseases. 展开更多
关键词 PLGA microsphere Icariin miR-23b Inhalation Metastatic lung cancer
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Spray-Drying Fabrication of Perovskite Quantum-Dot-Embedded Polymer Microspheres for Display Applications 认领 引用 被引量：2
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作者 Yuyu Jing Rongjian Zhang +11 位作者 Dengbao Han Huan Liu Wenchao Sun Shengquan Xie Ronghui Wang Xin Zhong Xian-gang Wu Qingchen Wang Zelong Bai Tao Zhang Jing Li Haizheng Zhong 《Engineering》 SCIE EI CSCD 2025年第8期221-228,共8页
Spray-drying is a widely used industrial technique to achieve the scale-up fabrication of functional powders.In this work,we report the spray-drying fabrication of perovskite quantum dot(PQD)microspheres from a precur... Spray-drying is a widely used industrial technique to achieve the scale-up fabrication of functional powders.In this work,we report the spray-drying fabrication of perovskite quantum dot(PQD)microspheres from a precursor solution at a scale of 2000 kg·a−1.The obtained PQDs are embedded in polymer microspheres,resulting in a high photoluminescence quantum yield and enhanced stability.By controlling the precursor concentration,the average size of the polymer microspheres can be tuned from 40.97 to 0.44μm.The as-prepared PQD-embedded polymer microspheres are mixed with ultraviolet adhesive to fabricate PQD-enhanced optical films for liquid crystal display(LCD)backlights.These films exhibit long-term operational stability under heat,humidity,and blue light irradiation(remaining at more than 90%initial photoluminescence intensity after a 1000 h aging test at 60℃ with 90%relative humidity and 70℃ with 455 nm 150 W·m−2 blue light irradiation).In addition,we demonstrate the use of PQD-embedded polymer microspheres as patterned color converters for micro light-emitting diode applications.Overall,this work demonstrates the scale-up fabrication of PQDs toward industrialization in display technology. 展开更多
关键词 Spray-drying fabrication Scale-up production Perovskite quantum dots Polymer microspheres
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Structural design of highly permeable Bi2O3 microspheres decorated by Pt-nanoparticles:facile synthesis and acetic acid sensing performance 认领 引用 被引量：2
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作者 Fan Yang Jun-Ning Zhang +4 位作者 Chao Zhang Xin-Da Xu Bing Li Woochul Yang Wan-Feng Xie 《Rare Metals》 SCIE EI CAS CSCD 2025年第9期6417-6425,共9页
Real-time detection of acetic acid vapor is of concern for ensuring environmental and personal safety.However,acetic acid gas sensors,particularly those based on Bi2O3,often fail to meet practical performance re... Real-time detection of acetic acid vapor is of concern for ensuring environmental and personal safety.However,acetic acid gas sensors,particularly those based on Bi2O3,often fail to meet practical performance requirements owing to their slow response characteristics and high operating temperature.To enhance sensing performance,highly permeable Bi2O3microspheres decorated by Pt-nanoparticles are rationally synthesized by a facile template method.Among the fabricated sensors,the one based on 3 wt%Pt-decorated Bi2O3demonstrated excellent sensing performance.Specifically,the sensor displayed high selectivity for acetic acid,rapid response and recovery times(22.5 and 9 s,respectively),strong resistance to interference,and good long-term stability at a low operating temperature(150℃).Notably,the sensor exhibited an exceptionally high response of 126 to 100 ppm acetic acid—the highest reported value for Bi2O3-based sensors tested at a relatively low operating temperature in recent years.These results demonstrate that Pt-decorated Bi2O3holds strong potential for use in high-performance acetic acid sensors. 展开更多
关键词 Semiconducting metal oxide Bi2O3microspheres Acetic acid Gas sensor
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Yttrium-90 microsphere therapy for hepatocellular carcinoma:Clinical efficacy,mechanistic insights,and comparative therapeutic perspectives 认领 引用 被引量：1
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作者 Yu-Hang Zhu Ming-Wei Wang +2 位作者 Yan Jiao Ya-Hui Liu Shan-Shan Dong 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第7期156-159,共4页
Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy live... Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes. 展开更多
关键词 Hepatocellular carcinoma Yttrium-90 microsphere therapy Radioembolization Dosimetry Clinical outcomes Comparative efficacy
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Controlled assembly engineering of Co@Co9S8-Glass micro-nano composite hollow microspheres towards microwave absorption improvement 认领 引用 被引量：1
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作者 Man Li Qianqian Jia +1 位作者 Zhenguo An Jingjie Zhang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第13期108-120,共13页
Multiscale shell structure design is a rational and promising way to regulate the performance of hollow spheres in terms of both functionality and structural robustness,but it remains a big challenge to realize micro-... Multiscale shell structure design is a rational and promising way to regulate the performance of hollow spheres in terms of both functionality and structural robustness,but it remains a big challenge to realize micro-nano engineering of the thin shell while maintaining the low density.In this work,the divisional shell design strategy was adopted to obtain the glass-cobalt-cobalt sulfide composite hollow microspheres(CSH),and an unprecedented stepwise high-temperature chemical reaction-induced aggregation and sub-sequent volume expansion strategy was developed to achieve rational regulation of core-shell structured cobalt-cobalt sulfide building units(BU)assembled on hollow glass microspheres.Special attention has been paid to the sulfidation degree-induced volume control with the underlying mechanism of volume expansion during chemical conversion from metallic cobalt to cobalt sulfide.The electromagnetic prop-erty was found to depend largely on the sulfidation degree due to the volume expansion-induced inter-connecting status regulation among the BU.When evaluated as microwave absorbent,an optimized broad bandwidth of 5.12 GHz and a minimum reflection loss(RLmin)of-45.58 dB of our CSH can be achieved at a thin matching thickness of 1.67 mm and a low filling ratio of 20.04 wt%.In addition to functionality,the divisional shell design also brings the CSH high structural strength(92.36%survival rate at a high hydrostatic pressure of 20 MPa)at low density(0.73 g cm-3). 展开更多
关键词 Hollow microspheres Micro-nano engineering Multiscale shell Interconnecting status Microwave absorption
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Fluorinated Monodisperse Microporous Microspheres:Formation Mechanism,Assembly,and Molecular Separation 认领 引用
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作者 Si-Yu Wang Xin-Rui Xu +3 位作者 Xin-Xin Qiu Xiao-Li Huang Xin-Qi Wang Zhi-Yong Chen 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2025年第1期162-176,I0012,共15页
The construction of monodisperse microporous organic microspheres is deemed a challenging issue,primarily due to the difficulty in achieving both high microporosity and uniformity within the microspheres.In this study... The construction of monodisperse microporous organic microspheres is deemed a challenging issue,primarily due to the difficulty in achieving both high microporosity and uniformity within the microspheres.In this study,a series of fluorinated monodisperse microporous microspheres are fabricated by solvothermal precipitation polymerization.The resulting fluorous methacrylate-based microspheres achieved higher than 400 m2/g surface area,along with a yield of over 90%for the microspheres.Through comprehensive characterization and simulation methods,we discovered that the introduction of fluorous methacrylate monomers at high loading levels is the key factor contributing to the formation of the microporosity within the microspheres.The controlled temperature profile was found to be advantageous for achieving a high yield of microspheres and increased uniformity.Two-dimensional assemblies of these fluorinated microsphere arrays exhibited superhydrophobicity,superolephilicity,and water sliding angles below 10°.Furthermore,a three-dimensional assembly of the fluorinated microporous microsphere in a chromatographic column demonstrated significant improvement in the separation of Engelhardt agent compared to commercial columns.Our work offers a novel approach to constructing fluorinated monodisperse microporous microspheres for advanced applications. 展开更多
关键词 Microporous microsphere Precipitation polymerization Fluorinated microsphere Superhydrophobicity Molecular separation
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Multifunctional microsphere dressings via metal ligand bonding engineering for infectious wound healing 认领 引用
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作者 Zhongyi Sun Ningning Cheng +10 位作者 Zhuyun Cai Zhengran Ying Haibo Liu Ziyan Chen Hua Zeng Mengting Yin Haijiang Liu Shuo Tan Xuhui Zhou Xinyu Zhao Feng Chen 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第16期158-172,共15页
Surgical incision infection is the most common postoperative complication that poses a serious threat to human health.In this work,the iron gallate(GA-Fe)modified hyaluronic acid microspheres(GFe@HAMSs)multifunctional... Surgical incision infection is the most common postoperative complication that poses a serious threat to human health.In this work,the iron gallate(GA-Fe)modified hyaluronic acid microspheres(GFe@HAMSs)multifunctional dressings with antibacterial activity,biodegradability,and the ability to promote tissue re-generation for infectious wound healing are prepared via the bonding engineering between bioactive iron ions and ligands from both polyphenol(i.e.gallic acid,GA)and HAMSs matrix.In our strategy,the Fe-HAMS interaction is first constructed,leading to the shrinkage of iron-doped HAMSs(Fe@HAMSs).Then,the addition of GA further tunes the metal-matrix bonding by introducing the competitive equilibrium between Fe-HAMS and Fe-GA chelation,leading to the volume expansion of GFe@HAMSs.The introduc-tion of iron ions can effectively shorten the inflammatory response and reverse the iron-deficient mi-croenvironment,thereby transforming the wound microenvironment into one conducive to tissue regen-eration.Benefitting from these bioactive effects of iron ions and the photothermal antibacterial activity of GA-Fe,the GFe@HAMSs significantly accelerate the wound healing process for rat skin-infected wounds by inhibiting the inflammatory response and macrophage polarization and promoting angiogenesis and tissue remodeling.The GFe@HAMSs proposed in this work not only provide a biomaterial for infectious wound healing but also offer a new strategy for designing multifunctional dressing. 展开更多
关键词 Iron gallate Hydrogel Microsphere Photothermal therapy Tissue regeneration
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Biomimetic soft magnetic cilia array actuator for rapid transport of solid microspheres 认领 引用
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作者 Han Ma Xiang-Yu Tang +6 位作者 Chun-Jie Wang Zi-Xuan Zhang Shuang Ben Si-Qi Wang Jia-Shuo Zhang Yang Shang Ke-Song Liu 《Rare Metals》 SCIE EI CAS CSCD 2025年第10期7751-7762,共12页
Developing flexible actuators with high transport efficiency is of great significance for the emerging applications of micro-robots in various industrial and biomedical environments.Despite recent advancements have en... Developing flexible actuators with high transport efficiency is of great significance for the emerging applications of micro-robots in various industrial and biomedical environments.Despite recent advancements have enabled soft materials to achieve complex functionalities unattainable by traditional rigid robots,achieving high-speed transport performance for solid particles remains a significant challenge.Magnetic materials,as an integral component of scientific applications,have demonstrated substantial potential in areas such as biological imaging,catalysis,and energy storage.Inspired by the flexible,soft,and elastic microciliary structures of many organisms,a soft actuator decorated with magnetic microcilia was reported.This soft magnetic microciliary actuator achieves high speed(50 mm s-1)transport of solid microspheres by means of magnetic field regulate their surface morphology.Overcoming the limitations of prior studies in which the speed of motion was constrained to a few millimeters per second due to hysteresis effects,this work represents a significant advancement in the emerging field of biomimetic flexible actuators and holds promise in various applications. 展开更多
关键词 Soft actuator Mangnetic responsiveness Flexible microcilia High-speed Microspheres transport
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