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A Synchronous Strategy to Zn-Iodine Battery by Polycationic Long-Chain Molecules 认领 引用 被引量：6
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作者 Da-Qian Cai Hengyue Xu +2 位作者 Tong Xue Jin-Lin Yang Hong Jin Fan 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期80-94,共15页
Aqueous Zn-iodine batteries(ZIBs)face the formidable challenges towards practical implementation,including metal corrosion and rampant dendrite growth on the Zn anode side,and shuttle effect of polyiodide species from... Aqueous Zn-iodine batteries(ZIBs)face the formidable challenges towards practical implementation,including metal corrosion and rampant dendrite growth on the Zn anode side,and shuttle effect of polyiodide species from the cathode side.These challenges lead to poor cycle stability and severe self-discharge.From the fabrication and cost point of view,it is technologically more viable to deploy electrolyte engineering than electrode protection strategies.More importantly,a synchronous method for modulation of both cathode and anode is pivotal,which has been often neglected in prior studies.In this work,cationic poly(allylamine hydrochloride)(Pah+)is adopted as a low-cost dual-function electrolyte additive for ZIBs.We elaborate the synchronous effect by Pah+in stabilizing Zn anode and immobilizing polyiodide anions.The fabricated Zn-iodine coin cell with Pah+(ZnI2 loading:25 mg cm−2)stably cycles 1000 times at 1 C,and a single-layered 3.4 cm2 pouch cell(N/P ratio~1.5)with the same mass loading cycles over 300 times with insignificant capacity decay. 展开更多
关键词 Polyiodide shuttle effect Halogen battery Conversion cathode Dendrites Polycation molecule
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Real-time regulation of zinc deposition/stripping by self-assembled molecule brush targeting proton for highly reversible Zn-ion battery 认领 引用
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作者 Zeping Liu Lijie Wang +5 位作者 Zeren Zhou Qixian Zhang Yixiang Zhang Wei Han Qiaoyan Lin Lishuang Fan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第2期541-549,I0012,共9页
Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the ad... Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H2 generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn2+for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10-3 g L-1 with a current density of5 mA cm-2.The cycle life of the Zn‖MnO2 and Zn‖Zn0.58V2O5 H2O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design. 展开更多
关键词 Zinc ion battery Zinc Anode Dynamic regulation Molecule brush Proton
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Activation of Sirtuin 3,a Promising“Head Goose Molecule,”Triggers the Negentropic Mechanism for Treating Metabolic Diseases 认领 引用
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作者 Hu Li Tong Wang +2 位作者 Biao Dong Zonggen Peng Jiandong Jiang 《Engineering》 SCIE EI CSCD 2026年第5期294-309,共16页
Metabolic diseases,such as diabetes,obesity,and steatotic liver disease,represent a global epidemic.The pathogenesis of these disorders involves systemic disturbances in glucose homeostasis,lipid metabolism,energy bal... Metabolic diseases,such as diabetes,obesity,and steatotic liver disease,represent a global epidemic.The pathogenesis of these disorders involves systemic disturbances in glucose homeostasis,lipid metabolism,energy balance,and inflammation,yet effective therapeutic strategies to correct these core disturbances remain limited.Silent information regulator 3(sirtuin 3(SIRT3)),a major mitochondrial deacetylase that we defined as the"head goose molecule,"acts as a central regulator and can initiate a coordinated rescue of metabolic homeostasis.We integrate evidence that SIRT3 activation triggers a"negentropic mechanism,"a suite of processes that collectively counteract systemic metabolic disorders by enhancing insulin sensitivity,promoting lipid oxidation,fine-tuning redox equilibrium,optimizing energy expenditure,and suppressing inflammation.The therapeutic potential of SIRT3 activators derived from natural products,synthetic compounds,and nicotinamide adenine dinucleotide(NAD+)precursors is evaluated,highlighting their promise as safe and sustainable treatment options.This review establishes the role of SIRT3 as a master regulator and suggests that it should be targeted to reconstitute systemic metabolic homeostasis. 展开更多
关键词 Sirtuin 3 Metabolic diseases Head goose molecule Negentropic mechanism Sirtuin 3 activator
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Energy‑Efficient Hydrogen Production via Coupled Small‑Molecule Oxidation at Industrial Current Densities 认领 引用
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作者 Jiajing Wu Guangqing Wang +7 位作者 Xikun Wang Weixiang Guan Delong Wang Xirui Xi Jiaqi Liu Feng Fu Ruan Chi Chunming Yang 《Transactions of Tianjin University》 EI CAS 2026年第2期193-218,共26页
The anodic small-molecule electrooxidation reaction,which is both thermodynamically and kinetically more favorable than the oxygen evolution reaction,when coupled with the hydrogen evolution reaction,has garnered incr... The anodic small-molecule electrooxidation reaction,which is both thermodynamically and kinetically more favorable than the oxygen evolution reaction,when coupled with the hydrogen evolution reaction,has garnered increasing attention and achieved significant progress.This method presents a promising avenue for hydrogen production at industrial current densities(≥200 mA/cm2)via water electrolysis while enabling the synthesis of value-added products or the removal of pollutants.However,the correlations among anode small-molecule types,catalyst design,reaction mechanisms,and electrolytic cell configuration remain unclear at industrial current densities.In this review,the characteristics and challenges of hydrogen production via coupling with various small-molecule oxidation reactions at industrial current densities are discussed for the first time,emphasizing key advances in catalyst design–substrate correlations,reaction mechanisms,and electrolytic cell configuration.Additionally,the challenges and future prospects of this field are explored. 展开更多
关键词 Small molecule oxidation Catalysts design Reaction mechanism Industrial current densities
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A strategy to improve the annotation coverage of small molecule compounds in fruits,vegetables and their products by untargeted metabolomics 认领 引用
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作者 Junyan Yu Lei Xu +8 位作者 Nan Zhang Lingxiao Tang Xiangyang Zhu Lu Mi Qiong Xu Kewen Wang Charles Viau Xue Wang Zhenzhen Xu 《Food Innovation and Advances》 2026年第1期112-122,共11页
Metabolomics is essential for analyzing small molecules in food.Effective extraction and separation technology,along with reliable and efficient analytical tools,are essential for enhancing both the quantity and accur... Metabolomics is essential for analyzing small molecules in food.Effective extraction and separation technology,along with reliable and efficient analytical tools,are essential for enhancing both the quantity and accuracy of compound analysis.Traditional methods relying on single-solvent extraction and singlecolumn separation often result in target omission and reduced annotation coverage.This study presents a'Divide,Conquer,and Integrate Strategy'for comprehensive untargeted metabolomics in fruits,vegetables,and their products.The method uses three extraction techniques to capture metabolites across a broad polarity range.Each extract is separated using specific chromatographic columns and mobile phases to ensure high annotation coverage.Data are collected via high-resolution mass spectrometry in both positive and negative ion modes,and analyzed using MS-DIAL and MetaboAnalystR.This integrated approach enhances metabolite discovery and annotation accuracy,with low overlap of metabolites annotated by different extraction methods. 展开更多
关键词 untargeted metabolomics chromatographic columns analyzing small molecules analytical toolsare enhancing both quantity accuracy compound analysistraditional high resolution mass spectrometry annotation coverage extraction techniques
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Photocatalyzed C-N coupling reactions of small molecules 认领 引用
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作者 Lin-Xing Zhang Chang-Long Tan +2 位作者 Ming-Yu Qi Zi-Rong Tang Yi-Jun Xu 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第1期7-19,共13页
Catalytic coupling of abundant CO2 or renewable CH3OH with nitrogenous small molecules,such as N2,H3,and NO3-,has emerged as a promising strategy for synthesizing high-value organonitrogen compounds.... Catalytic coupling of abundant CO2 or renewable CH3OH with nitrogenous small molecules,such as N2,H3,and NO3-,has emerged as a promising strategy for synthesizing high-value organonitrogen compounds.However,conventional thermal catalysis for C-N bond formation often relies on external chemical reagents and energy-intensive conditions,raising concerns about process sustainability.Photocatalysis offers a sustainable alternative by utilizing sunlight to generate high-energy electron-hole pairs in semiconductors,which can activate inert chemical bonds(e.g.,C=O and N≡N)for programmed coupling under ambient conditions.In this review,we dissect the fundamental activation mechanisms underlying photon-mediated C-N coupling reactions,highlight key recent breakthroughs in the synthesis of urea,formamide,and amino acids,and analyze persistent challenges alongside emerging opportunities.This work aims to deepen the understanding of photocatalytic C-N coupling reactions and inspire research interest in sustainable nitrogen fixation and carbon utilization. 展开更多
关键词 Photocatalytic C-N coupling reactions Small molecules Urea Formamide Amino acids
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Acceptor concentration dependent Förster resonance energy transfer in nanocrystal-molecule complexes revealed by spectral analysis 认领 引用
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作者 Rongxin ZHANG Zixiang ZHOU +3 位作者 Lei WANG Xin ZHANG Ying LIANG Guijie LIANG 《Optoelectronics Letters》 EI 2026年第3期150-153,共4页
A nanocrystal-molecule complex composed of CdSe donor and Rhodamine B(RhB)acceptor is prepared to investigate the effect of accepter-donor ratio on the Förster resonance energy transfer(FRET)process.To highlight ... A nanocrystal-molecule complex composed of CdSe donor and Rhodamine B(RhB)acceptor is prepared to investigate the effect of accepter-donor ratio on the Förster resonance energy transfer(FRET)process.To highlight the FRET process,the energy level alignment between CdSe and RhB is purposefully designed and CdSe nanocrystal is coated with a wide band gap ZnS shell.The carrier dynamics is observed via combined spectral analysis.The results reveal clear FRET process between the CdSe donor and RhB acceptor.The FRET is enhanced by increasing RhB/CdSe ratio and a gradual saturation will be present at high RhB concentration. 展开更多
关键词 combined spectral analysisthe wide band gap zns shellthe nanocrystal molecule complex fret process resonance energy carrier dynamics acceptor concentration F rster resonance energy transfer
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Electrocatalytic C–N coupling of carbon dioxide and nitrogen-containing small molecules for synthesizing organic nitrogenous compounds 认领 引用
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作者 Youyu Long Yingchun He +2 位作者 Wenbo Wei Hua Lin Qi-Long Zhu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期601-621,I0015,共21页
The electrocatalytic conversion of carbon dioxide(CO2)and nitrogen-containing pollutants(such as nitrate and ammonia)into high-value carbon–nitrogen(C–N)coupled compounds(such as urea,amines,amides,and amino acid... The electrocatalytic conversion of carbon dioxide(CO2)and nitrogen-containing pollutants(such as nitrate and ammonia)into high-value carbon–nitrogen(C–N)coupled compounds(such as urea,amines,amides,and amino acids)offers an innovative pathway that combines environmental and economic benefits to achieve a closed carbon-nitrogen cycle and green synthesis.Although the field holds great potential,it is still in its early stages and faces challenges such as complex reaction pathways,poor product selectivity,and unclear catalytic mechanisms.To systematically understand this complex chemical system and promote its further development,this review provides a comprehensive summary and critical evaluation of relevant research progress.Firstly,this study summarizes the key C–N coupling mechanisms involved in the electrocatalytic synthesis of urea,amines,amides,and amino acids,along with methods for detecting products and intermediates,as well as catalyst design strategies.Subsequently,based on the types of products,it delves into the reaction mechanisms,elucidating the critical steps and current research status of C–N bond formation across various systems.The significance of technoeconomic analysis(TEA)in the industrialization of electrocatalytic C–N coupling is also emphasized.Finally,drawing on an analysis of current challenges,it proposes future research directions,including leveraging machine learning to guide catalyst development,employing in-situ characterization to clarify the electrocatalytic C–N coupling mechanism,and promoting process integration to narrow the gap between laboratory and industrial-scale applications.This work aims to furnish a theoretical basis and technical guidance for further in-depth research and systematic optimization in this field. 展开更多
关键词 Electrocatalytic C–N coupling Carbon dioxide Catalyst design Nitrogen-containing small molecules Reaction pathway
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Mechanisms of anticancer active molecules from traditional Chinese medicine and strategies for clinical application 认领 引用
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作者 Xiang-Zan Wei Jing-Mei Yao +5 位作者 Shu-Xin Liang Yu-Yan Wang Jia-Yi Wang Piao-Liu Yuan Xian Zhou Wei-Rong Qin 《Traditional Medicine Research》 2026年第10期59-73,共15页
Traditional Chinese medicine(TCM)is a valuable source of bioactive molecules,whose potential to alter oncogenic processes associated with cancer includes aberrant proliferation,apoptotic resistance,and metastatic repr... Traditional Chinese medicine(TCM)is a valuable source of bioactive molecules,whose potential to alter oncogenic processes associated with cancer includes aberrant proliferation,apoptotic resistance,and metastatic reprogramming.This article is a systematic review on the mechanistic basis of anticancer TCM-derived compounds,mainly flavonoids,terpenoids,and polysaccharides.We focus on literature from 2005 till now.The TCM compounds described here are capable of inducing caspase-mediated apoptosis,inhibiting the PI3K/Akt/mTOR and Wnt/β-catenin signalling pathways,inhibiting epithelial-mesenchymal transition(EMT),enhancing NK cell cytotoxicity,and repolarizing tumor-associated macrophages(TAMs)in the tumor microenvironment(TME).The compounds,however,show promise in the preclinical and early clinical settings.The integration of TCM with western medicines raises challenges that require attention.These are poor bioavailability,incomplete mechanism understanding,and a lack of standardization.Our analysis indicates that TCM bioactives could potentially be used as new agents in precision oncology for resistant cancers.We additionally propose that the marriage of systems biology with adaptive clinical trial designs may accelerate their translation into next-generation anticancer regimens,with TCM poised to play a complementary cornerstone in modern oncology. 展开更多
关键词 traditional Chinese medicine anticancer active molecules mechanisms of action clinical application research strategies
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Small-molecule TREM2 agonists:From artificial intelligence driven discovery to therapeutic application in Alzheimer's disease 认领 引用
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作者 Sungwoo Cho Moustafa Gabr 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4904-4905,共2页
The Alzheimer's disease(AD)therapeutic landscape is evolving rapidly.While anti-amyloid antibodies have achieved regulatory approval,their incremental clinical benefits have intensified interest in neuroinflammati... The Alzheimer's disease(AD)therapeutic landscape is evolving rapidly.While anti-amyloid antibodies have achieved regulatory approval,their incremental clinical benefits have intensified interest in neuroinflammation as a complementary therapeutic axis.Triggering receptor expressed on myeloid cells 2(TREM2)represents a particularly attractive microglial target,given that loss-offunction variants confer a three-fold elevation in AD risk. 展开更多
关键词 loss function variants microglial targetgiven neuroinflammation triggering receptor expressed myeloid cells small molecule trem agonists alzheimers disease artificial intelligence driven discovery therapeutic application
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Interactions between small molecules and carbon-engine microbes:Key mechanisms driving soil carbon accumulation 认领 引用
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作者 Lin CHEN Jingwang LI Jiabao ZHANG 《Pedosphere》 SCIE CAS CSCD 2026年第2期377-380,共4页
Synergistic interactions between small molecules(SMs)and carbon-engine microbes(CEMs)play key roles in soil organic carbon(SOC)accumulation.The SMs(typically<1000 Da),primarily derived from root exudates and polyme... Synergistic interactions between small molecules(SMs)and carbon-engine microbes(CEMs)play key roles in soil organic carbon(SOC)accumulation.The SMs(typically<1000 Da),primarily derived from root exudates and polymer degradation,enhance CEM functions by fueling microbial metabolism via rapid uptake,elevating carbon use efficiency for persistent necromass formation,and enriching mineral-binding and aggregate-forming taxa. 展开更多
关键词 persistent necromass fueling microbial metabolism soil organic carbon root exudates carbon engine microbes small molecules sms synergistic interactions polymer degradationenhance
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A computational dataset for C1 molecules catalytic conversion over iron-based catalysts 认领 引用
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作者 ZHANG Jian LI Chaochao LU Kuan 《燃料化学学报（中英文）》 EI CAS CSCD 北大核心 2026年第6期226-232,共7页
The catalytic conversion of C1 molecules(e.g.,CO,CO2)represents a pivotal technology in the energy and chemical sectors,essential for achieving sustainable C1 chemistry and low-carbon transformation.A profound unde... The catalytic conversion of C1 molecules(e.g.,CO,CO2)represents a pivotal technology in the energy and chemical sectors,essential for achieving sustainable C1 chemistry and low-carbon transformation.A profound understanding of the underlying microscopic reaction mechanisms necessitates systematic support from both theoretical and experimental data support.This study constructs a“Computational Dataset for C1 Molecular Catalytic Conversion Based on Iron-Based Catalysts,”focusing on Fe5C2-based catalysts and systematically integrating multidimensional information on C1 molecular adsorption,dissociation,and formation reactions across different crystal surfaces(001,111,510).The dataset includes:the number of polycrystalline surface structures(Fe5C2(001)with 96 configurations,Fe5C2(111)with 93,and Fe5C2(510)with 472);species involved in the full reaction pathways under complex co-adsorption environments(adsorbed states such as COH and H2,dissociated states like CO under 2H conditions,and formation states such as CH/CH3 under 2H and H2O conditions);and a standardized hierarchical storage system categorizing reaction types,crystal surfaces,and structural parameters.This dataset not only serves as a benchmark for validating quantum chemical calculation methods but also provides critical data support for catalyst design and reaction pathway optimization in C1 molecular catalytic conversion by uncovering the coupling effects of crystal surfaces and reaction mechanisms. 展开更多
关键词 Fe5C2 C1 molecules density functional theory reaction mechanism dataset
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Breathing dynamics of dissipative pure quartic soliton molecules via spectral filtering effects 认领 引用
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作者 Chun-Ting Liu Jun-You Lu +1 位作者 Han-Yang Shen Zu-Xing Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第3期320-327,共8页
Although dissipative pure quartic solitons(DPQSs)stabilized by fourth-order dispersion(FOD)and nonlinearity are widely studied,their multi-soliton dynamics in positive FOD remain underexplored.Here,we study the impact... Although dissipative pure quartic solitons(DPQSs)stabilized by fourth-order dispersion(FOD)and nonlinearity are widely studied,their multi-soliton dynamics in positive FOD remain underexplored.Here,we study the impact of saturation energy and filter bandwidth on breathing DPQS molecules numerically.Our findings indicate that complementary breathing DPQS molecules exchange energy through oscillating tails,exhibiting simultaneously temporal oscillations and spectral shifting.By adjusting cavity parameters,we demonstrate that the state of breathing soliton molecules is inherently governed by time separation.These findings deepen the comprehension of multi-soliton interactions and nonlinear phenomena. 展开更多
关键词 dissipative pure-quartic soliton soliton molecule breathing soliton oscillating tails
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Double ionization of oxygen molecules in counter-rotating two-color elliptical polarization fields 认领 引用
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作者 Feng Gao Xiaolong Lu +3 位作者 Jun Liu Zifeng Wang Jiacheng Mao Peipei Xin 《Communications in Theoretical Physics》 SCIE CAS CSCD 2026年第4期108-116,共9页
The classical ensemble model(CEM)was applied to study the double ionization(DI)yield and correlated dynamics of electron pairs during non-sequential double ionization(NSDI)of oxygen molecules exposed to a counter-rota... The classical ensemble model(CEM)was applied to study the double ionization(DI)yield and correlated dynamics of electron pairs during non-sequential double ionization(NSDI)of oxygen molecules exposed to a counter-rotating two-color elliptically polarized(TCEP)laser field.Numerical simulations revealed a gradual reduction in the DI yield with increasing angle between the major axes of the two elliptically polarized laser components.This angular dependence arises from asymmetric suppression effects that the laser field exerts on the potential barrier of the diatomic molecule,with larger angles decreasing the efficiency of the barrier suppression.Concurrently,as molecular orientation angles increase,the increased travel time of the rescattering electron enhances recollision energies,thereby shifting the joint temporal distribution of ionization and recollision events toward diagonal alignment and altering the dominant NSDI pathways in oxygen molecules. 展开更多
关键词 non-sequential double ionization counter-rotating TCEP laser fields diatomic molecule
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Incorporation of an Extended Electron-Deficient Central Block Into Small-Molecule Acceptors Toward Enhanced-Performance Organic Solar Cells 认领 引用
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作者 Lan Xie Yizhi Jiang +8 位作者 Lu Chen Dingding Qiu Jicheng Yi Han Yu Jianqi Zhang Zhixiang Wei Joshua Yuk Lin Lai Shengjian Liu He Yan 《Aggregate》 EI CAS CSCD 2026年第6期274-282,共9页
Almost all high-performance acceptors currently rely on a single electron-withdrawing core or a core modified with electron-withdr awing groups,which significantly limits structural innovation.In this study,we introdu... Almost all high-performance acceptors currently rely on a single electron-withdrawing core or a core modified with electron-withdr awing groups,which significantly limits structural innovation.In this study,we introduced two novel extended electron-deficient units,[1,2,5]thiadiazolo[3,4-b]pyrazine(Tz-Qx)and[1,2,5]oxadiazolo[3,4-b]pyrazine(Dz-Qx),into the acceptor central cores.Coupled with fluorine and chlorine-substituted terminal groups,the performance of the acceptors can be synergistically optimized.A systematic investigation elucidates the impact of the central core and terminal groups on the intrinsic photoelectronic properties of the acceptors.Among the four acceptors—Tz-Qx-4F,Tz-Qx-4Cl,Dz-Qx-4F,and Dz-Qx-4Cl—Tz-Qx-4F demonstrated significant near-infrared absorption,excellent crystallinity,and enhanced aggregation capabilities.When blended with the polymer donor D18,the binary device achieved a remarkable power conversion efficiency(PCE)of 19.50%,accompanied by a record short-circuit current density(JSC)of 29.3 mA cm−2.This performance is attributed to the balanced charge transport properties and reduced non-radiative energy losses in the blend films.In stark contrast,Dz-Qx-based counterparts yielded substantially lower PCEs(∼9%),underscoring the profound influence of core heteroatom identity.This work highlights the critical influence of extended electron-deficient units and terminal groups on the molecular photovoltaic properties,providing valuable insights for the design of enhanced-performance organic solar cell acceptors. 展开更多
关键词 extended electron-deficient central block organic solar cells small molecule acceptor
Organometallic mechanically interlocked molecules featuring N-heterocyclic carbene ligands:Recent advances in synthesis and applications 认领 引用
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作者 Yi Li Ye Lu Shi-Ping Yang 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2026年第1期105-113,共9页
Coordination-directed synthesis has emerged as an effective and versatile approach for constructing mechanically interlocked molecules(MIMs).This field has long been dominated by Werner-type complexes featuring oxygen... Coordination-directed synthesis has emerged as an effective and versatile approach for constructing mechanically interlocked molecules(MIMs).This field has long been dominated by Werner-type complexes featuring oxygen and/or nitrogen donors,whereas assemblies incorporating N-heterocyclic carbene(NHC)donors remain underexplored.This review provides a comprehensive overview of the rapidly developing field of MIMs constructed from poly-NHC-based building blocks.By highlighting representative recent examples,this review focuses on the pivotal role of NHC ligands and the robustness of metal-CNHC bond in the construction of metallosupramolecular interlocked structures.In addition,it summarizes contemporary strategies for achieving efficient assembly,analyzes defining structural attributes of the resulting architectures,and outlines current challenges and emerging opportunities for future developments in NHC-based MIMs. 展开更多
关键词 N-heterocyclic carbene Mechanically interlocked molecules Supramolecular chemistry Synthetic strategies
A highly crystalline small molecule donor based on bithiazole units enabling efficient ternary all-small-molecule organic solar cells 认领 引用
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作者 Wentao Zou Yixuan Xu +9 位作者 Ke Sun Wenqing Zhang Huajun Xu Yuanyuan Kan Tao Liu Bingsuo Zou Yanna Sun Xiaotao Hao Yingguo Yang Ke Gao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第5期789-794,共6页
All-small-molecule organic solar cells(ASM-OSCs)have garnered widespread attention in recent years.However,their power conversion efficiencies(PCEs)still fall behind those of polymer donor-based devices,primarily due ... All-small-molecule organic solar cells(ASM-OSCs)have garnered widespread attention in recent years.However,their power conversion efficiencies(PCEs)still fall behind those of polymer donor-based devices,primarily due to the challenge of realizing optimized morphology in ASM-OSCs.Here,a highly crystalline small molecule donor(SMD)named ZW2 is synthesized and incorporated into the Zn PTSEH:6TIC system.The addition of ZW2 synergistically regulates the morphology,molecular crystallinity,and molecular packing of blends,facilitating efficient charge transport and suppressing charge recombination.Consequently,an impressive PCE of 16.30%was delivered in the ternary device.This work highlights the significance of employing a highly crystalline SMD as the third component in tuning the crystallinity and morphology of blends,providing feasibility for achieving high-efficiency ASM-OSCs. 展开更多
关键词 All-small-molecule organic solar cell Crystallinity Morphology Small molecule donor Ternary organic solar cells
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Hewei Jiangni granule(和胃降逆颗粒)alleviates visceral hypersensitivity of non-erosive reflux disease via stromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway 认领 引用 被引量：4
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作者 CHENG Yuan ZHANG Xiaosi +6 位作者 LI Junxiang ZHANG Liming DAI Yi XIE Chune SHI Lei LI Xiaohong KOU Fushun 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第1期1-12,共12页
OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)ransient receptor potential vanilloid subfamily member 1(TRPV1)pathw... OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)ransient receptor potential vanilloid subfamily member 1(TRPV1)pathway.METHODS:Qualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography.In vivo,animal model of non-erosive reflux disease(NERD)was established by fructose intake and restraint stress.HWJNG and Omeprazole were administered by gavage to the drug intervention group.Reflux and visceral hypersensitivity were analyzed by pathological changes,PH value test,mechanical paw withdrawal threshold,thermal withdrawal latency and mast cells(MCs)degranulation.In vitro,substance P(SP)-induced P815 cells and dorsal root ganglion(DRG)cells were cocultured.Expression in both mice and cells of STIM1,TRPV1,and esophageal visceral hypersensitivity-related gastrointestinal neurochemicals were validated by enzyme linked immunosorbent assays,quantitative realtime polymerase chain reaction(qRT-PCR)and Western blot.Moreover,overexpression and small interfering RNA against STIM1 were utilized to verify of the role of HWJNG in DRG cells.RESULTS:HWJNG significantly suppressed intercellular space widening,injury of mitochondrial,MCs degranulation,mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice.HWJNG inhibited expression of visceral hypersensitivityrelated gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells,and expression of the STIM1,TRPV1 and related neurotransmitters in DRG and DRG cells.STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca2+flow into the cytoplasmic space of DRG cells.Furthermore,HWJNG could reversed STIM1 overexpression induced upregulation of TRPV1.CONCLUSION:HWJNG suppressed intercellular space widening in NERD mice,stabilized MCs and restored neuronal hyperexcitability by regulating visceral hypersensitivity via STIM1/TRPV1 pathway. 展开更多
关键词 non-erosive reflux disease visceral hypersensitivity stromal interaction molecule 1 transient receptor potential channels Hewei Jiangni granule
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Research progress of small-molecule natural medicines for the treatment of ischemic stroke 认领 引用 被引量：4
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作者 Kui Liu Ling Wang Tao Pang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第1期21-30,共10页
Stroke is the second leading cause of disability and mortality worldwide,imposing a substantial socioeconomic burden on individuals and healthcare systems.Annually,approximately 14 million people experience stroke,wit... Stroke is the second leading cause of disability and mortality worldwide,imposing a substantial socioeconomic burden on individuals and healthcare systems.Annually,approximately 14 million people experience stroke,with ischemic stroke comprising nearly 85%of cases,of which 10%to 20%involve large vessel occlusions.Currently,recombinant tissue plasminogen activator(tPA)remains the only approved pharmacological intervention.However,its utility is limited due to a narrow therapeutic window and low recanalization rates,making it applicable to only a minority of patients.Therefore,there is an urgent need for novel therapeutic strategies,including pharmacological advancements and combinatory treatments.Small-molecule natural medicines,particularly those derived from traditional Chinese herbs,have demonstrated significant therapeutic potential in ischemic stroke management.These compounds exert multiple neuroprotective effects,such as antioxidation,anti-inflammatory action,and inhibition of apoptosis,all of which are critical in mitigating stroke-induced cerebral damage.This review comprehensively examines the pathophysiology of acute ischemic stroke(AIS)and highlights the recent progress in the development of small-molecule natural medicines as promising therapeutic agents for cerebral ischemic stroke. 展开更多
关键词 Natural medicines Small molecule Ischemic stroke Antioxidants Neuroinflammation
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A sterically-hindered organic molecule to modulate hydrogen bonding and the electrical double layer for highly reversible zinc anodes 认领 引用 被引量：1
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作者 Rongsheng Guo Yongfeng Huang +5 位作者 Chang Shu Rui Yao Yifu Gao Wenbao Liu Zhichun Si Feiyu Kang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第6期280-291,I0007,共12页
The practical application of emerging rechargeable aqueous zinc(Zn)batteries is challenged by the poor reversibility and cycling stability of Zn anodes,primarily due to parasitic side reactions.While numerous strategi... The practical application of emerging rechargeable aqueous zinc(Zn)batteries is challenged by the poor reversibility and cycling stability of Zn anodes,primarily due to parasitic side reactions.While numerous strategies have been proposed,balancing the suppression of side reactions with the maintenance of fast Zn plating/stripping kinetics remains a significant challenge.In this study,sucrose,a sterically-hindered organic molecule with abundant hydroxyl groups,is employed to suppress the side reactions and maintain the moderate kinetics of Zn plating/stripping by modulating the hydrogen bond network without altering the Zn2+solvation structure.Its steric hindrance effect further impedes the lateral diffusion of Zn atoms on the electrode surface within the electric double layer,effectively mitigating dendrite growth and stabilizing the electrodeposition process.Consequently,the formulated Suc/ZnSO4electrolyte achieves a remarkably Coulombic efficiency of 99.90% over 2600 cycles at 3 mA cm-2for 1 mAh cm-2in Zn‖Cu cells.The enhanced Zn anode reversibility leads to excellent cycling stability in Zn‖LiFePO4cells and Zn‖β-MnO2cells.This study underscores the potential of sterically-hindered organic molecule strategies to enhance Zn anode stability while maintaining favorable Zn deposition/stripping dynamics in aqueous Zn batteries. 展开更多
关键词 Organic molecule Steric effect Interfacial dynamics Hydrogen bonding Electrical double layer Zinc anodes
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