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Research on benefit coordination mechanism in renewable energy multi-energy complementary systems 认领 引用
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作者 Yanyue Wang Chongru Liu 《Global Energy Interconnection》 EI CSCD 2026年第3期544-554,共11页
Cooperation among multiple stakeholders in the complementary integration of renewable energy sources(hydro,wind,and solar power)can enhance the incremental benefits of each participant as well as the overall efficienc... Cooperation among multiple stakeholders in the complementary integration of renewable energy sources(hydro,wind,and solar power)can enhance the incremental benefits of each participant as well as the overall efficiency of the cooperative alliance.The interest coordination mechanism stands as a pivotal element in the development of such multi-energy complementary systems.This study adopts a three-tier hierarchical model comprising a primary layer,secondary layer,and tertiary layer.The primary layer is an efficiency-oriented cooperative game model based on collective rationality,which determines the installed capacities of hydro,wind,and solar power within the alliance by requiring that the incremental financial internal rate of return(FIRR)exceed the benchmark FIRR for joining the hydro-wind-solar integrated alliance.The secondary layer is a participation-oriented non-cooperative game model rooted in individual rationality.Building on the installed capacities defined by the primary layer,it calculates the FIRR for each energy type when developed independently and compares it with the incremental FIRR of alliance participation to assess the willingness of stakeholders to join the alliance.The tertiary layer is an equity-oriented bargaining game model.Leveraging the incremental FIRR from the primary layer and the individually rational FIRR from the secondary layer,it ascertains the equitable FIRR for each stakeholder through bargaining based on the principle of fairness.A case study of a specific renewable energy multi-energy complementary system validates the feasibility and effectiveness of the proposed mechanism. 展开更多
关键词 Hydro-wind-solar Multi-energy complementarity Benefit coordination mechanism Cooperative game Non-cooperative game Bargaining game Primary-secondary-tertiary Hierarchical decision-making
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Analysis of Renewable Energy Absorption and Economic Feasibility in Multi-Energy Complementary Systems under Spot Market Conditions 认领 引用 被引量：1
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作者 Xiuyun Wang Zipeng Zhang +1 位作者 Chuang Liu Guoliang Bian 《Energy Engineering》 EI 2025年第2期577-619,共43页
As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o... As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy. 展开更多
关键词 Multi-energy complementary systems spot market two-layer optimization new energy consumption
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Design of the Multi-Energy Complementary Distributed Energy System for Towns 认领 引用
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作者 Tieyin Zhang Weihan Song Song +2 位作者 Shubao Wang Yuegang Wang Yukun Chen 《Journal of Power and Energy Engineering》 2021年第4期53-60,共8页
The multi-energy complementary distributed energy system (MCDES) covers a variety of energy forms, involves complex operation modes, and contains a wealth of control equipment and coupling links. It can realize the co... The multi-energy complementary distributed energy system (MCDES) covers a variety of energy forms, involves complex operation modes, and contains a wealth of control equipment and coupling links. It can realize the complementary and efficient use of different types of energy, which is the basic component of the physical layer of the Energy Internet. In this paper, aiming at the demand of the energy application for towns, a distributed energy system based on multi-energy complementary is constructed. Firstly, the supply condition of the distributed energy for the demonstration project is analyzed, and the architecture of the multi-energy complementary distributed energy system is established. Then the regulation strategy of the multi-energy complementary distributed energy system is proposed. Finally, an overall system scheme for the multi-energy complementary distributed energy system suitable for towns is developed, which provides a solid foundation for the development and promotion of the multi-energy complementary distributed energy system. 展开更多
关键词 Multi-Energy Complementary Distributed Energy System System Scheme
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Coupling Mechanism,Thermodynamics and Environment Performance of a Multi-Energy Complementary Hybrid Power System Integrated with Solar Thermochemical Process 认领 引用
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作者 WANG Qiushi DUAN Liqiang +4 位作者 WANG Xiaomeng LIU Luyao HUANGShangyou LI Xinlu DING Xingqi 《Journal of Thermal Science》 SCIE EI CAS CSCD 2026年第4期1281-1303,共23页
In the quest to mitigate the energy crisis,a pivotal area of research is dedicated to the pursuit of efficient and clean energy utilization methods.This study delves into the development of a high-performance,eco-frie... In the quest to mitigate the energy crisis,a pivotal area of research is dedicated to the pursuit of efficient and clean energy utilization methods.This study delves into the development of a high-performance,eco-friendly multi-energy complementary distributed power system.By integrating a solar methane reforming thermochemical process with efficient solid oxide fuel cell-micro gas turbine power unit,and employing the innovative Kalina cycle to recover the low-temperature waste heat from exhaust gas,a new hybrid power system has been constructed.This system leverages solar methane reforming to transform the fluctuating solar energy into stable syngas chemical energy,facilitating a strategic cascade utilization of the fuel's chemical potential.Through the application of rigorous energy and exergy analysis methodologies,coupled with a thorough environmental assessment focusing on the life cycle assessment of pollutant emissions,this study unveils the intricate mechanism of fuel energy grade enhancement and solar energy grade optimization within the thermochemical reaction framework of solar-assisted methane steam reforming.The findings demonstrate a remarkable 23.02%increase in the lover heating value of the syngas produced through the thermochemical process,compared to that of pure methane,showcasing the system's ability to maximize the utilization of chemical and physical energy from the fuel.The novel power system has an energy efficiency of 62.05%and an exergy efficiency of 64.92%,surpassing the performance of benchmark systems by 10.59%and 10.99%,respectively.Furthermore,the system's annual specific carbon dioxide emission rate stands at a commendable0.3131 kg/kWh over its operational lifespan,underscoring its superiority and reinforcing its potential as a leading solution in the ongoing battle against the energy crisis. 展开更多
关键词 multi-energy complementarity solar thermochemistry coupling mechanism exergy analysis life time assessment
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Progress and prospects of fundamental research on multi-energy complementary distributed energy system 认领 引用
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作者 Yongping YANG Liqiang DUAN +10 位作者 Qibin LIU Xiaoze DU Changying ZHAO Jiangjiang WANG Nan ZHENG Fan JIAO Ligang WANG Jian SUN Chao XU Liu CUI Jun YAN 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2025年第9期34-60,共27页
Multi-energy complementary distributed energy system(MECDES)is an important development direction for the energy system.It has the advantages of energy conservation and environmental protection and has great potential... Multi-energy complementary distributed energy system(MECDES)is an important development direction for the energy system.It has the advantages of energy conservation and environmental protection and has great potential to realize efficient energy cascade utilization through the energy conversion and utilization of cooling,heating,and power in place,achieving a user-oriented energy supply.The present study thoroughly reviews the current research status and puts forward the key scientific issues that urgently need to be resolved by investigating the problems and challenges of the MECDES from the perspectives of the characterization of the energetic mass-energy potential,the synergistic transformation and energy-potential coupling mechanism of multi-energy complementation,energy quality improvement and storage,and proactive regulation of the MECDES.Furthermore,the latest research progress of the MECDES for trickling the key scientific issues is comprehensively presented by proposing the distributed energy system with the complementation of multi-energy sources,developing novel ways of the energy potential coupling and energy cascaded comprehensive utilization of multi-energy complementation,proposing a new theory of multi-energy complementation and energy potential coupling and a new mechanism of source complementation,processing matching and thermodynamic cycle system collaborative conversion of both the fossil energy and renewable energy,and developing a new method of proactive adjust and control for adapting to fluctuating energy input and various energy load demands.Finally,the prospects and recommendations for the future research and development direction of MECDES are provided. 展开更多
关键词 distributed energy system multi-energy complementation energy cascaded comprehensive utilization synergistic conversion and energy storage system proactive regulation
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An innovative multi-energy field-assisted ultra-precision machining technology:in-situ laser-magnetic dual-field assisted diamond cutting 认领 引用 被引量：1
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作者 Yintian Xing Yue Liu +8 位作者 Changlin Liu Yuhan Li Tengfei Yin Sen Yin Zhanwen Sun Zhiwei Zhu Changxi Xue Wai Sze Yip Suet To 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第2期710-741,共32页
Field-assisted diamond cutting technology is a significant machining method that utilizes external energy fields to enhance the manufacturing performance.However,aimed the emergence of advanced high-performance materi... Field-assisted diamond cutting technology is a significant machining method that utilizes external energy fields to enhance the manufacturing performance.However,aimed the emergence of advanced high-performance materials,traditional single-field-assisted machining struggles to meet stringent precision requirements.Therefore,this study introduces an innovative and unique multi-energy field-assisted ultra-precision machining technology,in-situ laser-magnetic dual-field assisted diamond cutting(LMDFDC),to transcend the limitations of conventional single-field-assisted cutting methods and advance the machinability of challenging materials,notably the multi-principal-element high-entropy alloy(HEA).To elucidate the fundamental science questions of“what occurs,what changes,and what improves”in this work,the phenomenological behaviors of the dual-field coupling interaction are systematically investigated through advanced characterization techniques,spanning macroscopic surface integrity to microscopic atomic arrangement.This comprehensive study encompasses integrated analyses of four machining techniques for HEA workpiece,namely dual-energy field,two single-energy fields,and no-energy field.The research results indicate that the dual-field coupling effect demonstrates a leap in manufacturing performance through thermo-magneto-mechanical multi-physical synergistic interactions,primarily manifested in improved surface quality,reduced subsurface damage,suppressed diamond tool wear,and enhanced material removal stability.The significance of in-situ LMDFDC technology resides in propelling frontier academic developments in multi-physics coupled manufacturing theories while uncovering innovative machining approaches for next-generation high-performance materials. 展开更多
关键词 multi-energy field-assisted machining technology ultraprecision diamond cutting technology laser field magnetic field high-entropy alloy
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Heat stress induced testicular impairment is related to orchitis and complement activation in Rongchang boars 认领 引用
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作者 Xiangyuan Ma Wenxue Shen +11 位作者 Junhao Ni Xihao Luo Lianqiang Che Bin Feng Lun Hua Yong Zhuo Zhengfeng Fang Shengyu Xu Jian Li Xuemei Jiang Yan Lin De Wu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期488-499,共12页
Background Heat stress(HS)is posing as a tremendous threat to the swine industry,due to the thermos-sensitive gonads of boars.Testes are immune-privileged organs in which spermatogenesis needs to remain undisturbed,wh... Background Heat stress(HS)is posing as a tremendous threat to the swine industry,due to the thermos-sensitive gonads of boars.Testes are immune-privileged organs in which spermatogenesis needs to remain undisturbed,whereas immune cells are thermo-sensitive,especially macrophages,which are the most abundant testicular immune cells.Our study aimed to unveil the underlying immune responses and assess their consequences on the semen quality of boars under HS.The results will aid in addressing environmental temperature-related seasonal infertility and in selecting the best boar for use in artificial insemination.Methods The 3-week experiment assigned 268-week-old Rongchang male pigs into thermal neutral pair-feed(TN-PF)and HS groups.During the last 2 weeks,which served as the HS period,the HS group was subjected to 14-day 35±1℃,while the TN-PF group was kept at 26±1℃.Pig gonad tissues were sampled at the end of HS period for assessments and measurements.Results Our findings confirmed HS-related reactions such as elevated respiration rate(P<0.05)and elevated heat shock protein 60(HSP60;P<0.05)and heat shock protein 90(HSP90;P<0.05)expression levels.Sperm motility(P=0.06)and progressive sperms(P=0.08)were decreased under HS as was a significant reduction in average straight-line velocity(VSL;P<0.05).Additionally,total abnormality levels increased(P<0.05).Fibrosis,caspase-3 expression,and accumulations of tumor necrosis factor-α(TNF-α;P<0.05)and interleukin-1β(IL-1β;P<0.05),along with an elevated macrophage composition(P<0.05)characterized the orchitis under HS.Single cell RNA sequencing(scRNA-seq)revealed fluctuations in engulfing and inflammatory signals in testicular macrophages(TMs).In particular,the complement cascade was promoted by CD163+macrophages,resulting in membrane attack complex(C5b-9)assembly(P<0.05).Linear regressions further revealed a negative correlation between C5b-9 and sperm motility(P<0.05),as well as near-negative correlations between the C5b-9 and both progressive motility(P=0.08)and VSL(P=0.06).Conclusions Our findings highlighted the relationship between HS,the onset of orchitis,and the activation of the complement system,all of which decreased the boar semen quality. 展开更多
关键词 Boar Complement Heat stress Macrophage Orchitis Semen quality Testis
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Multi-energy field coupling analysis and experimental validation of picosecond laser drilling assisted by ultrasonic shock-induced water flow 认领 引用
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作者 Pengfei Ouyang Yang Liu +7 位作者 Zhaoyang Zhang Xiaolei Chen Yufeng Wang Hao Zhu Kun Xu Jingtao Wang Xiankai Meng Shu Huang 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2026年第1期130-154,共25页
The latest generation of aero engines has set higher standards for thrust-to-weight ratio and energy conversion efficiency,making it imperative to address the challenge of efficiently and accurately machining film coo... The latest generation of aero engines has set higher standards for thrust-to-weight ratio and energy conversion efficiency,making it imperative to address the challenge of efficiently and accurately machining film cooling holes.It has been demonstrated that conventional long-pulse lasers are incapable of meeting the elevated quality surface finish requirements for these holes,a consequence of the severe thermal defects.The employment of backside water-assisted laser drilling technology confers a number of distinct advantages in terms of mitigating laser thermal damage,thus representing a highly promising solution to this challenge.However,significant accumulation of bubbles and machining products during the backside water-assisted laser drilling process has been demonstrated to have a detrimental effect on laser transmission and machining stability,thereby reducing machining quality.In order to surmount these challenges,a novel method has been proposed,namely an ultrasonic shock water flow-assisted picosecond laser drilling technique.Numerical models for ultrasonic acoustic streaming and particle tracking for machining product transport have been established to investigate the mechanism.The simulation results demonstrated that the majority of the machining products could rapidly move away from the machining area because of the action of acoustic streaming,thereby avoiding the accumulation of bubbles and products.Subsequent analysis,comparing the process performance in micro-hole machining,confirmed that the ultrasonic field could effectively eliminate bubble and chip accumulation,thus significantly improving micro-hole quality.Furthermore,the impact of ultrasonic and laser parameters on micro-hole quality under varying machining methods was thoroughly investigated.The findings demonstrated that the novel methodology outlined in this study yielded superior-quality micro-holes at elevated ultrasonic and laser power levels,in conjunction with reduced laser frequency and scanning velocity.The taper of the micro-holes produced by the new method was reduced by more than 25%compared with the other conventional methods. 展开更多
关键词 Ultrasonic vibration Water assisted laser drilling Multi-energy field composite Precision manufacturing
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Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFDMAC cascade 认领 引用
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作者 Tongling Huang Zihui Wang +13 位作者 Lu Gao Jun Gao Zhaocheng Lu Pengda Li Chon Him Choy Zhuolei Yuan Yanting Zhong Chang-An Geng Huaiyu Wang Kelvin W.K.Yeung Bin Li Haobo Pan Di Chen Min Guan 《Bone Research》 SCIE CAS CSCD 2026年第3期861-878,共18页
Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organsissues in metabolism and inflammation,yet little is known about the contribution of liver and marrow adipose tissue(MAT).He... Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organsissues in metabolism and inflammation,yet little is known about the contribution of liver and marrow adipose tissue(MAT).Here we show that MAT-derived complement factor D(CFD)and component 3(C3)derived from steatotic liver coordinately drive excessive alternative complement activation,resulting in cartilage damage in mice during aging and metabolic disorders.Mechanistically,estrogen-related receptorα(ESRRA)transcriptionally upregulates CFD responding to bone marrow adipocytes(BMAds)expansion.Inhibition of ESRRA/CFD signaling in BMAds blocks the chondrocyte senescence and catabolism triggered by C3 that is released from steatotic hepatocyte,interrupting C3-CFD-MAC cascade,thereby suppressing ERK1/2 phosphorylation and mitochondrial dysfunction.Adipocyte-specific ablation or pharmacological inhibition of ESRRA reduces CFD levels particularly in adipocyte-rich bone marrow,attenuating osteoarthritis progression in aged mice.Our findings highlight a key liver-MAT-cartilage axis bridged by C3-CFD-MAC pathway,raising the potential for adipocyte ESRRA-targeting therapies for aging-related metabolic osteoarthritis. 展开更多
关键词 steatotic liver cartilage damage excessive alternative complement activationresulting adipocyte Osteoarthritis Mitochondrial dysfunction Esrra Cfd
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Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament 认领 引用
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作者 Yu-Nan Man Lu-Yang Zhong +1 位作者 Yue-Liang Wen Mao-Lin He 《World Journal of Orthopedics》 2026年第3期133-151,共19页
BACKGROUND The clinical co-occurrence of periodontitis and ossification of the posterior longitudinal ligament(OPLL)suggests shared pathophysiological mechanisms,which remain poorly understood.AIM To elucidate the key... BACKGROUND The clinical co-occurrence of periodontitis and ossification of the posterior longitudinal ligament(OPLL)suggests shared pathophysiological mechanisms,which remain poorly understood.AIM To elucidate the key molecular and cellular mechanisms between periodontitis and OPLL.METHODS Transcriptomic datasets for human periodontitis and OPLL were integrated.We performed differential gene expression analysis,weighted gene co-expression network analysis,and cross-dataset meta-analysis.A comprehensive machine learning framework incorporating 10 algorithms was applied to identify core genes,with model interpretability assessed via SHapley Additive exPlanations.Single-cell RNA sequencing data from periodontitis tissues were used to validate cell-type-specific expression,and functional enrichment analyses were conducted to elucidate relevant pathways.RESULTS Multi-step analysis identified complement factor I(CFI)as a principal contributor to both conditions.CFI expression was consistently upregulated and demonstrated strong discriminatory capacity for periodontitis.At single-cell resolution,endothelial cells within the periodontitis microenvironment were observed to express CFI.Functional enrichment analysis indicated that CFI-positive cells were involved in pathways related to cell adhesion(focal adhesion,adherens junctions),inflammatory signaling(PI3K-Akt pathway),and bacterial infection responses.CONCLUSION CFI was identified as a pivotal node connecting periodontitis and OPLL,revealing novel mechanisms and suggesting its potential as a biomarker and therapeutic target. 展开更多
关键词 Ossification of the posterior longitudinal ligament Periodontitis Complement factor I Discriminatory biomarker Machine learning Transcriptome Single-cell RNA sequencing
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Complement C3a Suppresses Spinal Cord Neural Stem Cell Activation by Inhibiting UCHL1 via the NF-κB p65/Nrf2 Pathway 认领 引用
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作者 Lu Ding Xinyue Li +2 位作者 YaQin Guo Feng-Quan Zhou David Y.B.Deng 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期153-174,共22页
Activation of spinal cord neural stem cells(NSCs)and subsequent neurogenesis holds a promising alternative for spinal cord injury(SCI)repair.Our previous study demonstrated that complement C3a,derived from reactive as... Activation of spinal cord neural stem cells(NSCs)and subsequent neurogenesis holds a promising alternative for spinal cord injury(SCI)repair.Our previous study demonstrated that complement C3a,derived from reactive astrocytes,inhibits NSC proliferation by suppressing protein aggregate clearance through the deubiquitinating enzyme ubiquitin carboxy-terminal hydrolase L1(UCHL1)-proteasome system post-SCI.However,the potential molecular mechanism by which C3a modulates NSC activation via this pathway remains unclear.Here,we revealed that C3a/C3a receptor(C3aR)signaling activated NF-κB p65,which in turn inhibited Nrf2 activity and UCHL1 expression,resulting in diminished proteasome activity and the accumulation of protein aggregates,and ultimately impaired NSC activation.Both knockdown of NF-κB p65 and Nrf2 upregulation restored UCHL1 expression and proteasome activity in vitro,promoting NSC activation by enhancing protein aggregate clearance.Mechanistically,we found that NF-κB p65 regulated Nrf2 activity through a dual mechanism:(1)promoting Keap1-dependent ubiquitination and proteasome degradation of Nrf2;(2)inhibiting protein kinase C-mediated Nrf2 phosphorylation and nuclear translocation.Using the dual-luciferase reporter assay and chromatin immunoprecipitation(ChIP)analysis,we further identified UCHL1 as a direct transcriptional target of Nrf2.Importantly,in vivo experiments using SCI mice confirmed that either C3aR blockade,NF-κB p65 knockdown,or Nrf2 overexpression could rescue SCI-induced UCHL1 downregulation.Together,this study uncovers the C3a-NF-κB p65-Nrf2-UCHL1-proteasome axis as a critical regulator of NSC activation after SCI.This may provide novel molecular targets and intervention strategies for SCI repair. 展开更多
关键词 Complement C3a Neural stem cell activation UCHL1 NF-κB p65/Nrf2 pathway Protein aggregation clearance Spinal cord injury
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Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry 认领 引用 被引量：3
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作者 Shuang-Qing Wang Ming-Ji Jin +11 位作者 Ze-Ke Guo Dong-Ri Shen Li-Na Jin Fang Cheng Yan-Ru Zhao Teng Liu Yu-Cai Li Nuo-Ya Wang Ling-Qing Chen Wei Huang Xiu-Quan Quan Zhong-Gao Gao 《Military Medical Research》 SCIE CAS CSCD 2026年第4期559-587,共29页
Background:Diabetic foot ulcers(DFU),perpetually trapped in a vicious cycle of inflammation and ischemia,remain a significant clinical challenge.Exosomes(Exo)therapy holds promise for tissue repair,yet its functional ... Background:Diabetic foot ulcers(DFU),perpetually trapped in a vicious cycle of inflammation and ischemia,remain a significant clinical challenge.Exosomes(Exo)therapy holds promise for tissue repair,yet its functional potency and delivery efficiency are often limited.Methods:We proposed an integrated strategy combining trace elements(TE)programming,Exo engineering,and intelligent delivery to overcome both functional and delivery constraints.Multiple TE(Fe,Mg,Zn,Mn,and Se)were incorporated into a three-dimensional(3D)dynamic culture system to construct high-activity engineered Exo(3D-TE-Exo).The biological mechanisms were explored via transcriptomics,mitochondrial function assays,and oxidative stress analyses.A dual-network hydrogel,incorporating dynamic Schiff base bonds and ultraviolet(UV)-triggered disulfide bond reorganization,was developed for precise and sustained Exo release in vivo.Results:3D-TE-Exo achieved a yield of 1.9×1012particles/ml,representing a 29-fold increase over conventional culture(6.5×1010particles/ml).These Exo modulated the complement pathway,restored mitochondrial membrane potential,enhanced adenosine triphosphate(ATP)production,and activated autophagy,thereby alleviating oxidative stress,with complement 1q binding protein(C1QBP)identified as a key mediator.The hydrogel enabled prolonged Exo retention and controlled release at the wound site.In DFU rat models,this system achieved 89.71%wound closure by day 14,significantly higher than the 50.64%observed in controls.Conclusions:This study presents a synergistic approach integrating engineered Exo and smart biomaterials to accelerate DFU healing.The platform offers a multi-target intervention strategy with strong translational potential for the clinical management of chronic wounds. 展开更多
关键词 Exosomes(Exo) Hydrogel Trace element Diabetic foot ulcers(DFU) Complement 1q binding protein(C1QBP)
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Multi-Energy System Optimization of Costs Versus Carbon Dioxide Emissions for Flexibility.A Case Study in Italy 认领 引用
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作者 Marcelo Dario Rodas Britez Francesco Ghionda +1 位作者 Vasileios Tatsis Dimosthenis Ioannidis 《Energy Engineering》 EI 2026年第6期393-409,共17页
Current energy systems are increasingly complex,considering multi-energy systems,the integration of non-programmable renewable energy sources,and the simultaneous evaluation of multiple evaluation objectives(i.e.,cost... Current energy systems are increasingly complex,considering multi-energy systems,the integration of non-programmable renewable energy sources,and the simultaneous evaluation of multiple evaluation objectives(i.e.,costs vs carbon dioxide emissions).This complexity opens the opportunity to explore optimization algorithms as assistance for systematic and automatic management of energy systems.The implementation of a multi-energy system poses multiple challenges,including managing multiple energy vectors with different technologies applied across energy production,energy storage,and renewable energy sources.Also,multi-objective evaluation should be considered to manage reductions in costs and carbon dioxide emissions.Therefore,this paper proposes a multi-objective,multienergy optimization approach for managing the production of electricity,steam,and cold,integrated with photovoltaic(PV),a battery energy storage system(BESS),cogenerators(CCHP),and boilers.It implements a Linear Programming algorithm and evaluates costs vs carbon dioxide emissions on an hourly basis for three months.Historical data on electric energy and steam demand are provided from the evaluated industry.The data on prices(electric energy and natural gas)are taken from the historical hourly energy prices in Italy.The implementation has been tested in a pharmaceutical industry in Italy,enabling automatic optimization of the defined multi-energy system to evaluate energy production in terms of costs and carbon dioxide emissions.Also,the flexibility of the energy system,enabled by the storage system and the cogeneration system,is discussed in depth.The results show that the optimization system,using a Pareto front comparison,allows the selection between reducing costs and reducing carbon dioxide emissions,with values expressed as percentage differences from the actual operational baseline.The cost variations between the optimized solutions and the real cost at market prices range from−9%to 42%.Then,the corresponding variations in carbon dioxide emissions range from−61%to 16%.Finally,the flexibility of the multi-energy system is possible by managing the BESS and CCHP. 展开更多
关键词 Multi-objective optimization algorithm multi-energy system energy flexibility
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Coordinated operation of multi-terminal SOP enabled multi-level multi-energy system considering coupled electrical and thermal demand response 认领 引用
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作者 Feng Bi Da Xu +1 位作者 Ziyi Bai Dongjie Shi 《Global Energy Interconnection》 EI CSCD 2026年第2期386-404,共19页
The increasing integration of distributed generation(DG)into distribution systems poses significant challenges such as voltage violations and line overloads.With the growing coupling between electrical and thermal ene... The increasing integration of distributed generation(DG)into distribution systems poses significant challenges such as voltage violations and line overloads.With the growing coupling between electrical and thermal energy carriers,developing coordinated strategies for multi-energy systems has become essential to accommodate high DG penetration levels.However,most existing studies primarily address single-level multi-energy systems,leaving the flexible interconnection potential of multi-level configurations largely unexplored.This paper proposes a coordinated operation framework for multi-level multi-energy systems based on an energy storage-integrated multi-terminal soft open point(SOP)configuration.The overall system architecture,comprising multi-voltage distribution networks and multi-level heating systems,is first presented.By integrating IoT-enabled electrical and thermal demand response,a coordinated energy storage-integrated multi-terminal SOP model is developed to minimize both planning and operational costs.Case studies conducted on a representative multi-level multi-energy system verify the effectiveness of the proposed approach,demonstrating its superior operational flexibility and notable economic benefits. 展开更多
关键词 Multi-energy system optimization Integrated demand response Renewable energy Soft open point
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An Electricity-Carbon Synergy-Driven Optimization Method for Low-Carbon Operation of Multi-Energy Parks 认领 引用
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作者 Jiangyang Yuan Jiaowen Wu +4 位作者 Yi Gao Yuhao Fu Yuntao Bu Tianyu Chen Hao Yu 《Energy Engineering》 EI 2026年第2期38-67,共30页
In the pursuit of carbon peaking and neutrality goals,multi-energy parks,as major energy consumers and carbon emitters,urgently require low-carbon operational strategies.This paper proposes an electricity-carbon syner... In the pursuit of carbon peaking and neutrality goals,multi-energy parks,as major energy consumers and carbon emitters,urgently require low-carbon operational strategies.This paper proposes an electricity-carbon synergy-driven optimization method for the low-carbon operation ofmulti-energy parks.Themethod integratesmultienergy complementary scheduling with a tiered carbon trading mechanism to balance operational security,economic efficiency,and environmental objectives.A mixed-integer linear programming model is developed to characterize the coupling relationships and dynamic behaviors of key equipment,including photovoltaic systems,ground-source heat pumps,thermal storage electric boilers,combined heat and power units,and electrical energy storage systems.Furthermore,a tiered carbon trading model is established that incorporates carbon quota allocation and tiered carbon pricing to internalize carbon costs and discourage high-emission practices.Multi-scenario comparative analyses demonstrate that the electricity-carbon synergy scenario achieves a 42.64%reduction in carbon emissions compared to economy-oriented operation,while limiting the increase in operational costs to 20.85%.The carbon-prioritized scenario further reduces emissions by 9.7%,underscoring the inhibitory effect of the tiered carbon pricing mechanism on highcarbon activities.Sensitivity analyses confirm the model’s robustness against fluctuations in energy load,uncertainty in renewable generation,and variations in carbon price.This optimization method provides theoretical support for multi-energy coordinated scheduling and carbon responsibility allocation in industrial parks,offering valuable insights for promoting green transformation initiatives. 展开更多
关键词 Electricity-carbon synergy multi-energy park mixed-integer programming tiered carbon pricing
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Identification and screening of bioactive peptides against nephropathy derived from Mantidis Oötheca based on complement C3 inhibition 认领 引用
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作者 Shanshan Li Peiling Liu +3 位作者 Tiantian Zhang Shujun Jiang Faren Xie Yanliang Zhang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第1期100-111,共12页
Insects represent emerging sources of bioactive peptides and functional materials.Mantidis Oötheca(Sang-Piao-Xiao in Chinese,SPX)serves as an insect-derived medicine for treating kidney disease.This study demonst... Insects represent emerging sources of bioactive peptides and functional materials.Mantidis Oötheca(Sang-Piao-Xiao in Chinese,SPX)serves as an insect-derived medicine for treating kidney disease.This study demonstrated that supernatant(SPX)improved kidney function in adriamycin(ADR)-induced nephropathy mice model.Transcriptomic analysis revealed that SPX inhibited complement activation by targeting the MASP1-C3/C3a receptor(C3aR)pathway.Peptidomic analysis identified 304 peptides from SPX,with 49 peptides selected for evaluation using prediction tools and molecular docking with complement core protein C3.Three peptides(PMGFPFDR,FNDPK,AAQFFNR)exhibiting docking scores below-8.0 were synthesized to verify complement inhibition and anti-fibrotic activities.The synthetic peptide AAQFFNR demonstrated complement inhibitory activity,with an inhibitory complement hemolytic 50%(ICH50)value of 24.54μmol·L-1,and exhibited superior protective effects in ADR-induced HK-2 cells.Surface plasmon resonance(SPR)assay revealed direct interaction between AAQFFNR and complement C3 with Kdvalue of 16.8μmol·L-1.The reno-protective effect of AAQFFNR was subsequently verified in ADR-induced mice.This research provides initial evidence that complement C3-inhibiting peptides from insects demonstrate potential in preventing nephropathy through in silico and in vivo validation approaches. 展开更多
关键词 Mantidis Oötheca Nephropathy Complement C3 Peptide screening
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Niu Huang mitigates dextran sulfate sodium-induced colitis by modulating farnesoid X receptor activation and the complement 3/NLRP3 signaling pathway 认领 引用
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作者 Juan Shi Chong-Yang Ma +6 位作者 Xiao-Hui Zhang Kun-Jing Liu Jin-Ying Liu Qing-Guo Wang Xue-Qian Wang Fa-Feng Cheng Tian Xu 《World Journal of Gastroenterology》 SCIE CAS 2026年第17期135-155,共21页
BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory bowel disease for which effective therapies are lacking.Niu Huang(NH)is a traditional Chinese medicine used for inflammatory disorders.However,its protective ... BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory bowel disease for which effective therapies are lacking.Niu Huang(NH)is a traditional Chinese medicine used for inflammatory disorders.However,its protective effect on UC and its underlying mechanisms are unknown.AIM To uncover the mechanisms underlying the anti-colitis effects of the NH.METHODS Network pharmacology was applied to predict the active ingredients and targets of NH.Experimental validation was conducted in a dextran sulfate sodium-induced murine colitis model.The therapeutic efficacy was assessed using symptoms,histopathology,quantitative polymerase chain reaction,western blotting,immunohistochemistry and enzyme linked immunosorbent assay,while the underlying mechanism was investigated through integrated transcriptomic and proteomic analyses.In addition,the critical role of farnesoid X receptor(FXR)in mediating the effects of NH was validated using the FXR inhibitor guggulsterone and Fxr-/-mouse models.RESULTS Network pharmacology revealed that the bioactive component of NH is bile acid.Our animal experiments demonstrated that NH treatment significantly alleviated colitis symptoms and pathological damage.NH preserved intestinal mucosal integrity by upregulating occludin,claudin3,E-cadherin and leucine rich repeat containing G protein-coupled receptor 5 expression.Transcriptomic and proteomic analyses revealed that bile secretion,the nuclear factor kappa B signaling pathway and the complement and coagulation cascade pathway are key targets of NH.Western blotting confirmed that NH increased FXR levels and reduced P65,complement component 3(C3)and NOD-like receptor family pyrin domain containing 3(NLRP3)expression.Furthermore,experiments using Fxr-/-mice and the FXR antagonist revealed that FXR is a pivotal target through which NH attenuates UC.Mechanistic analysis revealed that the effects of NH on UC are mediated by the modulation of targets involved in the activation of FXR and the subsequent inhibition of C3/NLRP3 activation.CONCLUSION This study demonstrates the therapeutic effects of NH on UC.Mechanistically,NH acts by activating FXR,which subsequently inhibits the nuclear factor kappa B pathway to reduce C3 accumulation and suppress excessive NLRP3 inflammasome activation in colon tissue. 展开更多
关键词 Niu Huang Ulcerative colitis Network pharmacology Farnesoid X receptor Complement component 3/NOD-like receptor family pyrin domain containing 3 signaling pathway Inflammation
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Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation:A case report 认领 引用
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作者 Manish Ramesh Balwani Amit Pasari +13 位作者 Pranjal Kashiv Chaitanya Shembekar Manisha Shembekar Shubham Dubey Vijay Jeyachandran Sunny Malde Sushrut Gupta Twinkle Pawar Priyanka Tolani Mohit Kurundwadkar Prasad Gurjar Kapil Sejpal Charulata Bawankule Vivek B Kute 《World Journal of Transplantation》 2026年第1期256-262,共7页
BACKGROUND Complement-mediated thrombotic microangiopathy(TMA)is a rare endothelial injury syndrome caused by dysregulated activation of the alternative complement pathway,often linked to genetic abnormalities in comp... BACKGROUND Complement-mediated thrombotic microangiopathy(TMA)is a rare endothelial injury syndrome caused by dysregulated activation of the alternative complement pathway,often linked to genetic abnormalities in complement factor H(CFH),complement factor I,or complement factor H-related(CFHR)proteins.Both renal transplantation and pregnancy are independent triggers for recurrence.This case highlights a genetically high-risk patient who achieved a successful term pregnancy after renal transplantation without complement inhibition,emphasizing individualized risk stratification,close surveillance,and multidisciplinary management for favourable maternal and graft outcomes.CASE SUMMARY A 32-year-old woman with end-stage renal disease secondary to genetically confirmed complement-mediated TMA—homozygous CFH exon 17 deletion and CFHR3-CFHR1 duplication—was maintained on dialysis for 2.5 years before undergoing a successful live-donor kidney transplant from her mother.Post-transplant immunosuppression included tacrolimus,mycophenolate mofetil,and prednisolone,later modified to azathioprine during pregnancy planning.One-year post-transplant,she conceived spontaneously.Pregnancy was complicated by transient gestational hypertension,controlled with nifedipine,labetalol,and amlodipine.Proteinuria remained<150 mg/day;white blood cell counts 5.8-7.2×109/L without cytopenia.Serum creatinine ranged 0.9-1.1 mg/dL,and tacrolimus trough levels 5-7 ng/mL.At 36 weeks,she delivered a healthy 3 kg infant by elective caesarean section.Postpartum follow-up at three months confirmed stable maternal and graft function.CONCLUSION High-risk complement-mediated TMA patients can achieve successful pregnancy post-transplant through individualized care without mandatory complement blockade. 展开更多
关键词 Complement-mediated thrombotic microangiopathy CFH exon 17 deletion CFHR3-CFHR1 duplication Renal transplantation High-risk pregnancy Complement dysregulation Eculizumab-free management Atypical hemolytic uremic syndrome Case report
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The Extremal Graphs for the Spectral Radii of Complements of Graphs with Cut Vertices 认领 引用
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作者 Chen Xu Gao Guangyuan 《Journal of Mathematical Research with Applications》 CSCD 2026年第4期435-441,共7页
The adjacency matrix A(G)of a connected simple graph G is a symmetric(0,1)-matrix with real eigenvalues λ1≥λ2≥…≥λn.The maximum eigenvalueλ1 is called the spectral radius of G.In this paper,we characte... The adjacency matrix A(G)of a connected simple graph G is a symmetric(0,1)-matrix with real eigenvalues λ1≥λ2≥…≥λn.The maximum eigenvalueλ1 is called the spectral radius of G.In this paper,we characterize the extremal graphs that attain the maximum or minimum spectral radii among all graph complements in the family of graphs with cut vertices. 展开更多
关键词 spectral radius complements cut vertices
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CVaR-based Reserve Optimization for Isolated Multi-energy Complementary Generation Systems in Mixed Time Scale 认领 引用
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作者 Wanxiao Jiang Jichun Liu +1 位作者 Jawad Shafqat Yi Lei 《CSEE Journal of Power and Energy Systems》 SCIE EI CSCD 2024年第6期2597-2609,共13页
With the rapid growth of photovoltaic integration,the volatility and uncertainty of intermittent photovoltaic injection will dramatically reduce system operation reliability from the generation side.The system operato... With the rapid growth of photovoltaic integration,the volatility and uncertainty of intermittent photovoltaic injection will dramatically reduce system operation reliability from the generation side.The system operator may face certain financial risks brought by unexpected power failure under low operation reliability.Therefore,maintaining sufficient power reserve to meet system operation reliability and reduce risk,especially in an isolated system,is essential.However,the traditional reserve preparation strategy fails to consider the uncertainties of the power generation under the high penetration levels of emerging renewable energy resources.A novel reserve preparation strategy for an isolated system is developed in this paper using a twostage model.In the first stage,the optimal hourly scheduling of an isolated system is determined.In the second stage,a minute level conditional value-at-risk(CVaR)based model is established where the uncertainty of the reserve requirement is introduced with the chance constraint.The proposed discretized step transformation(DST)and subtraction type convolution(STC)methods are utilized to convert the model into mixedinteger linear programming,and finally solved by applying the CPLEX solver.The IEEE 39-bus system is used as the test case to validate the feasibility and effectiveness of the proposed two-stage model. 展开更多
关键词 Isolated multi-energy complementary generation system renewable energy reserve risk assessment
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