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Policy and science at a crossroads:integrating new approach methodologies(NAMs)into anticancer drug testing frameworks 认领 引用
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作者 Guo Zhao Jiawei Zhou +1 位作者 Shuhang Wang Ning Li 《Science Bulletin》 SCIE EI CAS CSCD 2026年第13期3241-3243,共3页
Pharmaceutical industry is navigating an inflection point characterized by profound scientific advancement juxtaposed against unsustainable translational inefficiencies.For decades,the foundational paradigm of antican... Pharmaceutical industry is navigating an inflection point characterized by profound scientific advancement juxtaposed against unsustainable translational inefficiencies.For decades,the foundational paradigm of anticancer drug development has relied on in vivo animal models to assess pharmacodynamics,efficacy,and safety prior to human trials. 展开更多
关键词 new approach methodologies anticancer drug testing human trials vivo animal models science crossroads anticancer drug development policy
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Animal research in the UK:Regulation,implementation,welfare and development of new approach methodologies 认领 引用
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作者 Ewan St.John Smith James Bussell +4 位作者 Maggie Gentry Elliot Lilley Cathy Merry Judy MacArthur Clark William Reynolds 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第5期1056-1062,共7页
Use of animals in biomedical research is still considered essential by many in aca-demia,industry and regulatory authorities.Therefore,it is important that legal,gov-ernance and welfare procedures are in place to ensu... Use of animals in biomedical research is still considered essential by many in aca-demia,industry and regulatory authorities.Therefore,it is important that legal,gov-ernance and welfare procedures are in place to ensure that only necessary procedures using animals are carried out and that this occurs within a framework with animal welfare at its core.Animal research in the United Kingdom is conducted under the Animals(Scientific Procedures)Act 1986 and animal research in the United Kingdom has long been seen as a flag bearer for high quality-high welfare research.An example of the leading role taken in supporting animal welfare in research was establishment of the National Centre for the Replacement,Refinement and Reduction of Animals in Research(NC3Rs)to support reducing the scale and impact of animal research.Here,we provide an overview of governance and licensing procedures of animal research in the United Kingdom,coupled with explanations of how excellent welfare underpins high quality research,and examine the development of new approach methodologies. 展开更多
关键词 3Rs New approach methodologies Regulation Welfare
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