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GcH1 contributes to high-altitude adaptation in Tibetans by regulating blood nitric oxide 认领 引用 被引量：2
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作者 Yongbo Guo Wangshan Zheng +6 位作者 Tian Yue Baimakangzhuo Xuebin Qi Kai Liu Liya Li Yaoxi He Bing Su 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第1期97-109,共13页
Nitric oxide(NO)is a key vasodilator that regulates vascular pressure and blood flow.Tibetans have developed a"blunted"mechanism for regulating NO levels at high altitude,with GTP cyclohydrolase 1(GCH1)ident... Nitric oxide(NO)is a key vasodilator that regulates vascular pressure and blood flow.Tibetans have developed a"blunted"mechanism for regulating NO levels at high altitude,with GTP cyclohydrolase 1(GCH1)identified as a key candidate gene.Here,we present comprehensive genetic and functional analyses of GCH1,which exhibits strong Darwinian positive selection in Tibetans.We show that Tibetan-enriched GCH1 variants down-regulate its expression in the blood of Tibetans.Based on this observation,we generate the heterozygous Gch1 knockout(Gch1+/-)mouse model to simulate its downregulation in Tibetans.We find that under prolonged hypoxia,the Gch1+/-mice have relatively higher blood NO and blood oxygen saturation levels compared with the wild-type(WT)controls,providing better oxygen supplies to the cardiovascular and pulmonary systems.Markedly,hypoxia-induced cardiac hypertrophy and pulmonary remodeling are significantly attenuated in the Gch1^(+/-)mice compared with the WT controls,likely due to the adaptive changes in molecular regulations related to metabolism,inflammation,circadian rhythm,extracellular matrix,and oxidative stress.This study sheds light on the role of GCH1 in regulating blood NO,contributing to the physiological adaptation of the cardiovascular and pulmonary systems in Tibetans at high altitude. 展开更多
关键词 GCH1 Nitric oxide Tibetans High altitude Hypoxia Adaptation
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Microenvironment Responsive Polymeric Nitric Oxide Releasing Micelles for Enhancing Eradication of Methicillin-resistant Staphylococcus aureus Biofilm 认领 引用
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作者 Hui‑Fang Ma Zheng‑Xin Ma +4 位作者 Gang‑Feng Li Yu‑Tong Yang Zhi‑Heng Yang Dan Xing Peng Li 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第7期2167-2176,共10页
Biofilm infections pose a severe threat to global public health owing to their persistent and recalcitrant nature.The physical barrier formed by the biofilm impedes the penetration of antimicrobial agents,leading to a... Biofilm infections pose a severe threat to global public health owing to their persistent and recalcitrant nature.The physical barrier formed by the biofilm impedes the penetration of antimicrobial agents,leading to a significantly reduced efficacy of conventional antibiotics.Herein,we developed a polymeric micelle system that responds to the biofilm microenvironment to release nitric oxide(NO),which is capable of disrupting biofilms,thereby enhancing the bactericidal efficacy of antibiotics against embedded bacteria.The hydrophobic small-molecule NO donor was first conjugated to a diblock copolymer composed of N-hydroxyethyl acrylamide and N-acryloyl morpholine to yield an amphiphilic diblock copolymer.This amphiphilic copolymer then self-assembles into polymeric NO-releasing micelles(PNOM).Upon exposure to thiol-containing molecules in the reducing biofilm microenvironment,PNOM responsively released NO in a sustained manner over several days.In vitro studies have demonstrated that PNOM significantly potentiated the anti-biofilm efficacy of levofloxacin(Lev)against methicillin-resistant Staphylococcus aureus(MRSA).The combination of PNOM and Lev dispersed 85.3%of the biofilm biomass and eradicated 98.8%of the embedded bacteria.Moreover,in a murine model of implant-associated MRSA biofilm infection,PNOM was validated to enhance the antibiofilm efficacy of Lev in vivo,achieving a bactericidal rate of 93.9%for MRSA biofilms and significantly alleviating inflammation.In summary,we designed a polymeric micelle system that triggers NO release in response to a thiol-rich biofilm microenvironment,thereby disrupting biofilm formation and enhancing the antibiofilm effect of antibiotics against MRSA.This approach represents a promising therapeutic strategy for treating stubborn biofilm-associated infections. 展开更多
关键词 Polymeric Micelles Nitric oxide Drug-resistant bacteria Biofilm infection
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Electrocatalytic ammonium nitrate synthesis through integrating nitric oxide redox reactions over porphyrinic metal-organic frameworks 认领 引用
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作者 Yi Tan Xiaokang Chen +4 位作者 Jian Yuan Guan Sheng Wei-Qiao Deng Ghim Wei Ho Hao Wu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第5期558-565,I0013,共8页
The conversion of nitric oxide(NO),a gaseous pollutant with an intermediate nitrogen oxidation state,into value-added ammonium nitrate(NH4NO3)via redox processes offers a sustainable alternative to conventional ... The conversion of nitric oxide(NO),a gaseous pollutant with an intermediate nitrogen oxidation state,into value-added ammonium nitrate(NH4NO3)via redox processes offers a sustainable alternative to conventional disposal methods,which are hampered by competing pathways that yield undesirable byproducts.Herein,we decouple the synthesis of NH4NO3into electrochemical NO oxidation(NOOR)and reduction(NORR)by employing H-terminated and Cu-metallated porphyrinic metal-organic framework catalysts(H-PMOF and Cu-PMOF,respectively),leveraging their tailored coordination environments and varied NO adsorption configurations.The H-PMOF favors O-atom adsorption via hydrogen bonding,whereas the Cu-PMOF strengthens N-atom adsorption through Cu-N interactions.They promote NOOR tand NORR to N,respectively,achieving greater Faradaic efficiencies and yield rates compared to their respective counterparts.When integrated in one electrolyzer,they enable direct synthesis of NH4NO3by generating 662.4μmol of Nand 409.5μmol of NH4+hourly.Molecular dynamics simulations reveal differences in adsorption modes,while computational results identify the ratedetermining dehydrogenation(*HNO3→*NO3for NOOR)and hydrogenation steps(*NO→~*NHO for NORR),with both catalysts exhibiting reduced energy barriers.This work presents a strategy for directing NO redox reactions through coordination engineering,paving the way for sustainable nitrogen valorization. 展开更多
关键词 Nitric oxide Porphyrin Metal-organic frameworks Ammonium nitrate
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Role of Nitric Oxide in Mitigating Cadmium Stress in Plants:Mechanisms and Perspectives 认领 引用
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作者 Mohammad Reza Boorboori Haiyang Zhang 《Phyton-International Journal of Experimental Botany》 SCIE 2026年第6期1-17,共17页
Cadmium(Cd)is a toxic heavy metal pollutant released from various human activities including industrial production and agricultural practices.This pollutant adversely affects plant physiology by damaging root systems,... Cadmium(Cd)is a toxic heavy metal pollutant released from various human activities including industrial production and agricultural practices.This pollutant adversely affects plant physiology by damaging root systems,inhibiting photosynthesis,and inducing oxidative stress through the accumulation of reactive oxygen species(ROS).This review highlights the critical role of nitric oxide(NO)as a key signaling molecule that enhances plant tolerance to cadmium stress.The application of exogenous NO effectively alleviates Cd toxicity by stimulating the activity of antioxidant enzymes such as superoxide dismutase(SOD)and catalase(CAT),scavenging harmful ROS,and preventing membrane damage.Furthermore,NO improves nutrient absorption and photosynthetic efficiency under Cd stress.The review also explores the complex interactions between NO and other phytohormones,including auxin and brassinosteroids,especially in regulating root development under stressful conditions.Despite these protective effects,the review concludes that further investigations are needed to better understand the molecular mechanisms of NO signaling,its concentration-dependent responses,and its specific crosstalk with other plant signaling molecules. 展开更多
关键词 Cadmium nitric oxide stress reduction plants mechanisms
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A rethinking of nitrate,nitrite,and nitric oxide for food preservation and human health 认领 引用
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作者 Xiaojing Tian Yanan Tian +4 位作者 Lele Shao Yu Li Shaohua Meng Jiansheng Zhao Wenhang Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1581-1595,共15页
Nitrate and nitrite,as long-standing additives used in food industry and particularly prevalent in meat products,are often perceived negatively by consumers due to their potential to produce carcinogenic nitrosamines.... Nitrate and nitrite,as long-standing additives used in food industry and particularly prevalent in meat products,are often perceived negatively by consumers due to their potential to produce carcinogenic nitrosamines.Within the past decades,the importance of nitric oxide(NO)has been established for human health,including cardiovascular health,immunizing and defending system,skeletal muscle contraction and relaxation,nervous system,and cognitive function.Gradually,nitrate and nitrite,as the main NO donors,have also been demonstrated to have numerous health benefits in clinical studies.Likewise,NO has showed positive effect on postharvest fruits and vegetables.In view of different controversies,this review comprehensively discussed the effect of nitrate,nitrite on meat products and NO on fruits and vegetables,the intake of nitrate and nitrite by diet,the physiological functions,synthesis and metabolism of nitrate,nitrite,and NO in human body.It is hoped to provide some new understanding for nitrate,nitrite,and NO in food preservation and human health. 展开更多
关键词 Nitrate Nitrite Nitric oxide Food preservation Human health
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Boron‑Insertion‑Induced Lattice Engineering of Rh Nanocrystals Toward Enhanced Electrocatalytic Conversion of Nitric Oxide to Ammonia 认领 引用
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作者 Peng Han Xiangou Xu +13 位作者 Weiwei Chen Long Zheng Chen Ma Gang Wang Lei Xu Ping Gu Wenbin Wang Qiyuan He Zhiyuan Zeng Jinlan Wang Dong Su Chongyi Ling Zhengxiang Gu Ye Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第3期85-102,共18页
Electrocatalytic nitric oxide(NO)reduction reaction(NORR)is a promising and sustainable process that can simultaneously realize green ammonia(NH3)synthesis and hazardous NO removal.However,current NORR performances ar... Electrocatalytic nitric oxide(NO)reduction reaction(NORR)is a promising and sustainable process that can simultaneously realize green ammonia(NH3)synthesis and hazardous NO removal.However,current NORR performances are far from practical needs due to the lack of efficient electrocatalysts.Engineering the lattice of metal-based nanomaterials via phase control has emerged as an effective strategy to modulate their intrinsic electrocatalytic properties.Herein,we realize boron(B)-insertion-induced phase regulation of rhodium(Rh)nanocrystals to obtain amorphous Rh4B nanoparticles(NPs)and hexagonal close-packed(hcp)RhB NPs through a facile wet-chemical method.A high Faradaic efficiency(92.1±1.2%)and NH3 yield rate(629.5±11.0μmol h−1 cm−2)are achieved over hcp RhB NPs,far superior to those of most reported NORR nanocatalysts.In situ spectro-electrochemical analysis and density functional theory simulations reveal that the excellent electrocatalytic performances of hcp RhB NPs are attributed to the upshift of d-band center,enhanced NO adsorption/activation profile,and greatly reduced energy barrier of the rate-determining step.A demonstrative Zn-NO battery is assembled using hcp RhB NPs as the cathode and delivers a peak power density of 4.33 mW cm−2,realizing simultaneous NO removal,NH3 synthesis,and electricity output. 展开更多
关键词 Lattice engineering of nanomaterials Phase engineering of nanomaterials Wet-chemical synthesis Metal nanocatalysts Nitric oxide reduction reaction Electrocatalytic ammonia synthesis
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Letter to the Editor: DAF-FM fluorescent probe: Advancing early detection of esophagitis-to-cancer transformation through nitric oxide imaging 认领 引用
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作者 Sachin Namdeo Kothawade Vijaya Padwal 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第4期292-295,共4页
Chen et al published a study in the recent issue of World Journal of GastrointestinalSurgery evaluated the high-performance fluorescent probe DAF-FM provides asignificant advancement in early esophageal cancer detecti... Chen et al published a study in the recent issue of World Journal of GastrointestinalSurgery evaluated the high-performance fluorescent probe DAF-FM provides asignificant advancement in early esophageal cancer detection. DAF-FM enablesreal-time monitoring of nitric oxide during esophagitis-to-cancer transformation,with concentration-dependent and time-dependent fluorescence, lysosomal targeting,and low cytotoxicity. In preclinical models, DAF-FM fluorescence stronglycorrelates with tumor volume (R² = 0.87) and demonstrates superior sensitivitycompared to endoscopic biopsy. These findings position DAF-FM as a rapid, noninvasive,and clinically relevant tool for early diagnosis and treatment monitoringin high-risk esophagitis patients. 展开更多
关键词 DAF-FM Fluorescent probe Nitric oxide Esophagitis Early detection Molecular imaging Esophageal cancer Translational research
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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia 认领 引用 被引量：3
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作者 Xiaorong Zhang Zhiying Chen +3 位作者 Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第2期402-415,共14页
With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic... With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic rate.However,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia patients.Similarly in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive decline.Nitric oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous system.Recently,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular dementia.This review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular dementia.Additionally,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia. 展开更多
关键词 endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia
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Effects of different nitric oxide synthases on pulmonary and systemic hemodynamics in hypoxic stress rat model 认领 引用 被引量：3
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作者 Huan Zhang Yu Zhang +2 位作者 Xiaojun Wang Jie Liu Wei Zhang 《Animal Models and Experimental Medicine》 CAS CSCD 2025年第2期344-352,共9页
Background:Under hypoxia,exaggerated compensatory responses may lead to acute mountain sickness.The excessive vasodilatory effect of nitric oxide(NO)can lower the hypoxic pulmonary vasoconstriction(HPV)and peripheral ... Background:Under hypoxia,exaggerated compensatory responses may lead to acute mountain sickness.The excessive vasodilatory effect of nitric oxide(NO)can lower the hypoxic pulmonary vasoconstriction(HPV)and peripheral blood pressure.While NO is catalyzed by various nitric oxide synthase(NOS)isoforms,the regulatory roles of these types in the hemodynamics of pulmonary and systemic circulation in living hypoxic animals remain unclear.Therefore,this study aims to investigate the regu-latory effects of different NOS isoforms on pulmonary and systemic circulation in hypoxic rats by employing selective NOS inhibitors and continuously monitoring hemodynamic parameters of both pulmonary and systemic circulation.Methods:Forty healthy male Sprague–Dawley(SD)rats were randomly divided into four groups:Control group(NG-nitro-D-arginine methyl ester,D-NAME),L-NAME group(non-selective NOS inhibitor,NG-nitro-L-arginine methyl ester),AG group(in-ducible NOS inhibitor group,aminoguanidine),and 7-NI group(neurological NOS in-hibitor,7-nitroindazole).Hemodynamic parameters of rats were monitored for 10 min after inhibitor administration and 5 min after induction of hypoxia[15%O2,2200 m a.sl.,582 mmHg(76.5 kPa),Xining,China]using the real-time dynamic monitoring model for pulmonary and systemic circulation hemodynamics in vivo.Serum NO concentra-tions and blood gas analysis were measured.Results:Under normoxia,mean arterial pressure and total peripheral vascular resist-ance were increased,and ascending aortic blood flow and serum NO concentration were decreased in the L-NAME and AG groups.During hypoxia,pulmonary arterial pressure and pulmonary vascular resistance were significantly increased in the L-NAME and AG groups.Conclusions:This compensatory mechanism activated by inducible NOS and en-dothelial NOS effectively counteracts the pulmonary hemodynamic changes induced by hypoxic stress.It plays a crucial role in alleviating hypoxia-induced pulmonary arte-rial hypertension. 展开更多
关键词 hypoxic stress nitric oxide synthase peripheral vascular resistance pulmonary vascular resistance
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Role of nitric oxide in cerebral ischemia/reperfusion injury:A biomolecular overview 认领 引用 被引量：1
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作者 Roberto Anaya-Prado Abraham I Canseco-Villegas +14 位作者 Roberto Anaya-Fernández Michelle Marie Anaya-Fernandez Miguel A Guerrero-Palomera Citlalli Guerrero-Palomera Ivan F Garcia-Ramirez Daniel Gonzalez-Martinez Consuelo Cecilia Azcona-Ramírez Claudia Garcia-Perez Airim L Lizarraga-Valencia Aranza Hernandez-Zepeda Jacqueline F Palomares-Covarrubias Jorge HA Blackaller-Medina Jacqueline Soto-Hintze Mayra C Velarde-Castillo Dayri A Cruz-Melendrez 《World Journal of Clinical Cases》 2025年第10期9-13,共5页
Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively expre... Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively expressed.NO can serve different purposes:As a vasoactive molecule,as a neurotransmitter or as an immunomodulator.It plays a key role in cerebral ischemiaeperfusion injury(CIRI).Hypoxic episodes simulate the production of oxygen free radicals,leading to mitochondrial and phospholipid damage.Upon reperfusion,increased levels of oxygen trigger oxide synthases;whose products are associated with neuronal damage by promoting lipid peroxidation,nitrosylation and excitotoxicity.Molecular pathways in CIRI can be altered by NOS.Neuroprotective effects are observed with eNOS activity.While nNOS interplay is prone to endothelial inflammation,oxidative stress and apoptosis.Therefore,nNOS appears to be detrimental.The interaction between NO and other free radicals develops peroxynitrite;which is a cytotoxic agent.It plays a main role in the likelihood of hemorrhagic events by tissue plasminogen activator(t-PA).Peroxynitrite scavengers are currently being studied as potential targets to prevent hemorrhagic transformation in CIRI. 展开更多
关键词 Nitric oxide Cerebral ischemiaeperfusion injury Nitric oxide synthase Reactive nitrogen species Nitrosylation
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Atractylenolide Ⅰ ameliorates post-infectious irritable bowel syndrome by inhibiting the polymerase Ⅰ and transcript release factor and c-Jun N-terminal kinase/inducible nitric oxide synthase pathway 认领 引用 被引量：1
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作者 YUAN Jianan CHENG Kunming +4 位作者 LI Chao ZHANG Xiang DING Zeyu LI Bing ZHENG Yongqiu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2025年第1期57-65,共9页
OBJECTIVE:To explore the therapeutic effect and target of atractylenolide I(AT-I)on post-infectious irritable bowel syndrome(PI-IBS)rats.METHODS:Therefore,the preliminarily mechanism of AT-I in anti-PI-IBS were first ... OBJECTIVE:To explore the therapeutic effect and target of atractylenolide I(AT-I)on post-infectious irritable bowel syndrome(PI-IBS)rats.METHODS:Therefore,the preliminarily mechanism of AT-I in anti-PI-IBS were first predicted by network pharmacology and molecular docking,then the possible signaling pathways were systematically analyzed.Finally,the potential therapeutic targets and possible signaling pathways of AT-I on PI-IBS in Sprague-Dawley(SD)rat model were verified by experiments.RESULTS:AT-I could alleviate PI-IBS symptoms and reduce the expression of tumor necrosis factorα,interleukin-6 and Interferon-gamma in PI-IBS SD rat model and inhibit the c-Jun N-terminal kinase/inducible nitric oxide synthase(JNK/iNOS)pathway.Notably,AT-I treatment could inhibit the overexpression of polymeraseⅠand transcript release factor(PTRF).CONCLUSION:AT-I could alleviate PI-IBS symptoms through downregulation of PTRF and inhibiting the JNK/iNOS pathway.This study not only provides a scientific basis to clarify the anti-PI-IBS effect of AT-I and its mechanism but also suggests a novel promising therapeutic strategy to treat the PI-IBS. 展开更多
关键词 atractylenolideⅠ post-infectious irritable bowel syndrome polymeraseⅠand transcript release factor network pharmacology MAP kinase signaling system nitric oxide synthase typeⅡ
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Nitric oxide synthase 1 inhibits the progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein 认领 引用
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作者 Zi-Wei Xiao Ying-Chao Zeng +2 位作者 Lin-Tao Ji Jia-Tao Yuan Lin Li 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第4期427-441,共15页
BACKGROUND Esophageal cancer(ESCA)is among the most prevalent and lethal tumors globally.While nitric oxide synthase 1(NOS1)is recognized for its important in-volvement in various cancers,its specific function in ESCA... BACKGROUND Esophageal cancer(ESCA)is among the most prevalent and lethal tumors globally.While nitric oxide synthase 1(NOS1)is recognized for its important in-volvement in various cancers,its specific function in ESCA remains unclear.AIM To explore the potential role and underlying mechanisms of NOS1 in ESCA.METHODS Survival rates were analyzed using GeneCards and Gene Expression Profiling Interactive Analysis.The effects and mechanisms of NOS1 on ESCA cells were evaluated via the Cell Counting Kit-8 assay,scratch assay,Transwell assay,flow cytometry,quantitative polymerase chain reaction,western blotting,and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling staining.The protein interaction network was used to screen the interacting proteins of NOS1 and validate these interactions through co-immuno-precipitation and dual luciferase assays.Additionally,a nude mouse xenograft model was established to evaluate the effect of NOS1 in vivo.RESULTS The survival rate of patients with ESCA with high NOS1 expression was higher than that of patients with low NOS1 expression.NOS1 expression in ESCA cell lines was lower than that in normal esophageal epithelial cells.Overexpression of NOS1(oe-NOS1)inhibited proliferation,invasion,and migration abilities in ESCA cell lines,resulting in decreased autophagy levels and increased apoptosis,pyroptosis,and ferroptosis.Protein interaction studies confirmed the interaction between NOS1 and NOS1 adaptor protein(NOS1AP).Following oe-NOS1 and the silencing of NOS1AP,levels of P62 and microtubule-associated protein 1 light chain 3 beta increased both in vitro and in vivo.Furthermore,the expression levels of E-cadherin,along with the activation of phosphatidylinositol 3-kinase(PI3K)and protein kinase B(AKT),were inhibited in ESCA cell lines.CONCLUSION NOS1 and NOS1 proteins interact to suppress autophagy,activate the PI3K/AKT pathway,and exert anti-cancer effects in ESCA. 展开更多
关键词 Nitric oxide synthase 1 Nitric oxide synthase 1 adaptor protein Autophagy Phosphatidylinositol 3-kinase/protein kinase B pathway Esophageal cancer
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Tumor-specific liquid metal nitric oxide nanogenerator for enhanced breast cancer therapy 认领 引用
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作者 Chen Su Jianhan Lin +11 位作者 Cong Li Xinyu Wang Donghui Pan Lizhen Wang Yuping Xu Chongyang Chen Kangfan Ji Jinqiang Wang Daozhen Chen Min Yang Zhen Gu Junjie Yan 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2025年第2期175-187,共13页
Nitric oxide(NO)modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment and integrated platforms for combination or synergistic therapies.Althoug... Nitric oxide(NO)modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment and integrated platforms for combination or synergistic therapies.Although a nanoengineering strategy has been proposed to overcome deficiencies of NO gas or small NO donor molecules,such as short half-life,lipophilicity,non-selectivity,and poor stability,it remains challenging to prepare NO nanomedicines with simple composition,multiple functions and enhanced therapeutic efficacy.Herein,we build a liquid metal nanodroplet(LMND)-based NO nanogenerator(LMND@HSG)that is stabilized by a bioreducible guanylated hyperbranched poly(amido amine)(HSG)ligand.Mechanically,the tumor microenvironment specifically triggers a cascade process of glutathione elimination,reactive oxygen species(ROS)generation,and NO release.According to actual demand,the ROS and NO concentrations could be readily controlled by tuning the LMND and HSG feed amounts.Along with the intrinsic anticancer property of LMND(ROS-mediated apoptosis and anti-angiogenesis),LMND@HSG administration could further enhance tumor growth suppression compared with LMND and HSG alone.Fromthis study,leveraging LMND for NO gas therapy provides more possibilities for the prospect of LMND-based anticancer nanomedicines. 展开更多
关键词 Liquid metal Nitric oxide Gas therapy Cancer treatment Nanomedicine
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Electrocatalytic Nitric Oxide Reduction to Yield Ammonia over Fe3C Nanocrystals 认领 引用
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作者 Sen Lin Lang Zhang +4 位作者 Tong Hou Jun-Yang Ding Zi-Mo Peng Yi-Fan Liu Xi-Jun Liu 《电化学（中英文）》 CAS 北大核心 2025年第4期1-11,共11页
Nitric oxide(NO),which generally originates from vehicle exhaust and industrial flue gases,is one of the most serious air pollutants.In this case,the electrochemical NO reduction reaction(NORR)not only removes the atm... Nitric oxide(NO),which generally originates from vehicle exhaust and industrial flue gases,is one of the most serious air pollutants.In this case,the electrochemical NO reduction reaction(NORR)not only removes the atmospheric pollutant NO but also produces valuable ammonia(NH3).Hence,through the synthesis and modification of Fe3C nanocrystal cata-lysts,the as-obtained optimal sample of Fe3C/C-900 was adopted as the NORR catalyst at ambient conditions.As a result,the Fe3C/C-900 catalyst showed an NH3Faraday efficiency of 76.5%and an NH3yield rate of 177.5μmol·h-1·cm-2at the working potentials of-0.8 and-1.2 V versus reversible hydrogen electrode(vs.RHE),respectively.And it delivered a stable NORR activity during the electrolysis.Moreover,we attribute the high NORR properties of Fe3C/C-900 to two aspects:one is the enhanced intrinsic activity of Fe3C nanocrystals,including the lowering of the energy barrier of rate-limiting step(*NOH→*N)and the inhibition of hydrogen evolution;on the other hand,the favorable dispersion of active components,the effective adsorption of gaseous NO,and the release of liquid NH3products facilitated by the porous carbon substrate. 展开更多
关键词 Nitric oxide reduction NH3 synthesis Fe3C nanocrystal Electrolysis Theoretical calculation
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Lanthanide nitric oxides(LnNO,Ln=La-Lu)present unique trend in bonding structure and oxidation states of Ln 认领 引用
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作者 Zhi-Yu Wei Shu-Xian Hu 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2025年第9期11-13,共3页
Scientists have devoted considerable effort overs several decades to reduce automobile exhaust emissions,and one practical and important strategy is the catalytic conversion of nitric oxide(NO)[1].Previous studies hav... Scientists have devoted considerable effort overs several decades to reduce automobile exhaust emissions,and one practical and important strategy is the catalytic conversion of nitric oxide(NO)[1].Previous studies have shown that lanthanide(Ln)metals can catalytically reduce NO.Thus,the reactions of NO with Ln to form lanthanide-nitric oxide(LnNO)complexes have been designed and served as the simplest prototype molecules for studying NO chemisorption on metal surfaces[2]. 展开更多
关键词 lanthanide prototype molecules nitric oxide metal surfaces catalytic conversion automobile exhaust emissions catalytic reduction chemisorption
MXene Hydrogel Microneedles with Nitric Oxide and HIF-1α Plasmid Controllable Releasing for Wound Healing 认领 引用 被引量：1
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作者 Wanchuan Ding Xiangyi Wu +3 位作者 Yi Cheng Ling Lu Weijian Sun Yuanjin Zhao 《Engineering》 SCIE EI CSCD 2025年第10期301-310,共10页
Microneedle technology is valuable in wound treatment.Current studies focus on optimizing the function of microneedles and screening for effective encapsulated actives.Herein,we develop innovative MXene hydrogel micro... Microneedle technology is valuable in wound treatment.Current studies focus on optimizing the function of microneedles and screening for effective encapsulated actives.Herein,we develop innovative MXene hydrogel microneedles with nitric oxide(NO)and hypoxia-inducible factor-1α(HIF-1α)plasmid controllable release for diabetic wound treatment.These microneedles consist of gelatin coupled with tert-butyl nitrite(Gel-SNO)polymers obtained by conjugating the-SNO group on the gelatin side chain,therefore,NO can be generated and released under near-infra red(NIR)light irradiation owing to the thermal effect.Simultaneously,by harnessing the enhanced photothermal conversion efficiency of the MXene additive,the microneedle patch can quickly dissolve and liberate the enclosed HIF-1αplasmid nanoparticles into the dermis when exposed to NIR radiation.The released NO effectively reduced the inflammatory response and released HIF-1αplasmid induced neovascularization.Thus,in vivo experiments showed that these microneedles could accelerate wound closure by alleviating inflammation,and promoting re-epithelialization and angiogenesis.These results indicated the potential value of MXene hydrogel microneedles in wound healing and other related biomedical fields. 展开更多
关键词 MXene hydrogel Microneedle Thermos-responsive Nitric oxide Hypoxia-inducible factor-1αplasmid Wound healing
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New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury 认领 引用 被引量：6
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作者 Yi-Ping Zhang Xin-Ran Liu +2 位作者 Mei-Wen Yang Shu-Long Yang Fen-Fang Hong 《World Journal of Hepatology》 2022年第3期504-515,共12页
Hepatic ischemia-reperfusion injury(HIRI)is a major clinical cause of morbidity and mortality in liver surgery and transplantation.Many studies have found that nitric oxide(NO)plays an important role in the HIRI and i... Hepatic ischemia-reperfusion injury(HIRI)is a major clinical cause of morbidity and mortality in liver surgery and transplantation.Many studies have found that nitric oxide(NO)plays an important role in the HIRI and its increase or decrease can affect the progression and outcome of HIRI.However,the role of NO in HIRI is controversial and complicated.NO derived by endothelial NO synthase(eNOS)shows a protective role in HIRI,while excessive NO derived by inducible NO synthase(iNOS)accelerates inflammation and increases oxidative stress,further aggravating HIRI.Nevertheless,the overexpression of eNOS may exacerbate HIRI and iNOS-derived NO in some cases reduces HIRI.Here we review the new progress in the understanding of the roles of NO during HIRI:(1)NO possesses different roles in HIRI by increasing NO bioavailability,down-regulating leukotriene C4 synthase,inhibiting the activation of the nuclear factorκB(NFκB)pathway,enhancing cell autophagy,and reducing inflammatory cytokines and reactive oxygen species(ROS).And NO has both protective and deleterious effects by regulating apoptotic factors;(2)eNOS promotes NO production and suppresses its own overexpression,exerting a hepatoprotective effect reversely.Its activation is regulated by the PI3K/Akt and KLF2/AMPK pathways;and(3)iNOS derived NO mainly has deteriorating effects on HIRI,while it may have a protective function under some conditions.Their expression should reach a balance to reduce the adverse side and make NO protective in the treatment of HIRI.Thus,it can be inferred that NO modulating drugs may be a new direction in the treatment of HIRI or may be used as an adjunct to mitigate HIRI for the purpose of protecting the liver. 展开更多
关键词 Hepatic ischemia-reperfusion injury Nitric oxide Endothelial nitric oxide synthase Inducible nitric oxide synthase
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Computational insights and strategic choices of nitrate and nitric oxide electroreduction to ammonia 认领 引用
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作者 Pu Guo Shaoxue Yang +3 位作者 Huijuan Jing Dong Luan Jun Long Jianping Xiao 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2025年第10期220-226,共7页
Electrochemical nitrate reduction(eNO3RR)and nitric oxide reduction(eNORR)to ammonia have emerged as promising and sustainable alternatives to the traditional Haber-Bosch method for ammonia production,particularly ... Electrochemical nitrate reduction(eNO3RR)and nitric oxide reduction(eNORR)to ammonia have emerged as promising and sustainable alternatives to the traditional Haber-Bosch method for ammonia production,particularly within the recently proposed reverse artificial nitrogen cycle route:N2→NOx→NH3.Notably,experimental studies have demonstrated that eNORR exhibits superior performance over eNO3RR on Cu6Sn5 catalysts.However,the fundamental mechanisms underlying this difference remain poorly understood.Herein,we performed systematic theoretical calculations to explore the reaction pathways,electronic structure effects,and potential-dependent Faradic efficiency associated with ammonia production via these two distinct electrochemical pathways(eNORR and eNO3RR)on Cu6Sn5.By implementing an advanced‘adaptive electric field controlled constant potential(EFC-CP)’methodology combined with microkinetic modeling,we successfully reproduced the experimental observations and identified the key factors affecting ammonia production in both reaction pathways.It was found that eNORR outperforms eNO3RR because it circumvents the *NO2 dissociation and *NO2 desorption steps,leading to distinct surface coverage of key intermediates between the two pathways.Furthermore,the reaction rates were found to exhibit a pronounced dependence on the surface coverage of *NO in eNORR and *NO2 in eNO3RR.Specifically,the facile desorption of *NO2 on the Cu6Sn5 surface in eNO3RR limits the attainable surface coverage of *NO,thereby impeding its performance.In contrast,the eNORR can maintain a high surface coverage of adsorbed *NO species,contributing to its enhanced ammonia production performance.These fundamental insights provide valuable guidance for the rational design of catalysts and the optimization of reaction routes,facilitating the development of more efficient,sustainable,and scalable techniques for ammonia production. 展开更多
关键词 Reverse ammonia production Electrocatalysis Nitric oxide reduction Nitrate reduction Constant potential Density functional theory calculation Microkinetic modeling
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Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum 认领 引用 被引量：1
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作者 Petra Talapka Nikolett Bódi +2 位作者 Izabella Battonyai éva Fekete Mária Bagyánszki 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第8期1026-1029,共4页
AIM:To study the cell-type specific subcellular distribution of the three isoforms of nitric oxide synthase(NOS) in the rat duodenum.METHODS:Postembedding immunoelectronmicroscopy was performed,in which primary antibo... AIM:To study the cell-type specific subcellular distribution of the three isoforms of nitric oxide synthase(NOS) in the rat duodenum.METHODS:Postembedding immunoelectronmicroscopy was performed,in which primary antibodies for neuronal NOS(nNOS),endothelial NOS(eNOS),and inducible NOS(iNOS),were visualized with protein A-gold-conjugated secondary antibodies.Stained ultrathin sections were examined and photographed with a Philips CM10 electron microscope equipped with a MEGAVIEW II camera.The specificity of the immunoreaction in all cases was assessed by omitting the primary antibodies in the labeling protocol and incubating the sections only in the protein A-gold conjugated secondary antibodies.RESULTS:Postembedding immunoelectronmicroscopy revealed the presence of nNOS,eNOS,and iNOS immunoreactivity in the myenteric neurons,the enteric smooth muscle cells,and the endothelium of capillariesrunning in the vicinity of the myenteric plexus of the rat duodenum.The cell type-specific distributions of the immunogold particles labeling the three different NOS isozymes were revealed.In the control experiments,in which the primary antiserum was omitted,virtually no postembedding gold particles were observed.CONCLUSION:This postembedding immunoelectronmicroscopic study provided the first evidence of celltype-specific differences in the subcellular distributions of NOS isoforms. 展开更多
关键词 Postembedding immunoelectronmicroscopy Subcellular distribution Neuronal nitric oxide synthase Endothelial nitric oxide synthase Inducible nitric oxide synthase
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Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview 认领 引用 被引量：1
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作者 Sadettin Demirel Ipek Nazli Sinag 《World Journal of Clinical Cases》 2025年第25期1-14,共14页
Lung cancer is the most frequent cause of cancer-related mortality worldwide.Nitric oxide(NO),prostaglandins(PGs),thromboxanes(TXs),and endothelins(ETs)participate in numerous physiological processes.These agents play... Lung cancer is the most frequent cause of cancer-related mortality worldwide.Nitric oxide(NO),prostaglandins(PGs),thromboxanes(TXs),and endothelins(ETs)participate in numerous physiological processes.These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation,apoptosis,invasion,and angiogenesis.NO is a gaseous free radical with tumo-ricidal and tumorigenic activities in lung cancer.Arachidonic acid-derived PGs,including PGD2,PGE2,8-iso-PGF2α,and PGI2,are related to the development of lung cancer.PGD2 and PGI2 act as tumor suppressors,while PGE2 and 8-iso-PGF2αpromote tumor progression.TXA2 catalyzed by cyclooxygenase induces prolif-eration as well as angiogenesis.Elevated levels of TXB2,an inactive metabolite of TXA2,are positively correlated with lung carcinoma stages.ET-1 and ET-2 are 21 amino acid polypeptides;their silencing hinders lung cancer cell proliferation and invasion.ET-2 depletion also triggers apoptotic death.This chapter review aims to provide a comprehensive overview of the role of NO,PGs,TXs,and ETs in lung cancer. 展开更多
关键词 Endothelins Lung cancer Nitric oxide Prostaglandins Thromboxanes
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