期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到471篇文章
< 1 2 … 24 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Potential mechanisms of non-coding RNA regulation in Alzheimer's disease 认领 引用 被引量：4
1
作者 Yue Sun Xinping Pang +5 位作者 Xudong Huang Dinglu Liu Jingyue Huang Pengtao Zheng Yanyu Wei Chaoyang Pang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期265-280,共16页
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica... Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies. 展开更多
关键词 Alzheimer's disease biomarkers circular RNA long non-coding RNA microRNA ncRNA regulation neurodegeneration non-coding RNA pathogenesis therapeutic targets
暂未订购 下载PDF
The regulatory network composed of phytohormones,transcription factors and non-coding RNAs is involved in the flavonoids biosynthesis of fruits 认领 引用 被引量：1
2
作者 Xiaoyuan Zheng Xuejiao Zhang Fankui Zeng 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第3期497-508,共12页
Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the reg... Flavonoids,abundant in the fruits,are pivotal to their growth,development,and storage.In addition,they have significant beneficial effects on human health.Consequently,research is increasingly concentrating on the regulatory mechanisms governing flavonoid biosynthesis in fruits.Phytohormones are involved in the regulation of flavonoid biosynthesis.The abscisic acid,ethylene,jasmonic acid,cytokinins,and brassinosteroids promote flavonoid biosynthesis,while auxin negatively regulates flavonoid biosynthesis.Subsequently,transcription factors from the MYB,bHLH,WRKY,NAC,and bZIP families are pivotal in regulating flavonoid biosynthesis.In addition,non-coding RNAs(microRNA and lncRNA)also participate in the regulation of flavonoids biosynthesis.MicroRNAs are generally believed to negatively regulate flavonoid metabolism in fruits,while lncRNAs have the opposite effect.Furthermore,the interactions between plant hormones,transcription factors,and non-coding RNAs in fruit flavonoid biosynthesis were analyzed.Ultimately,a foundational regulatory network for fruit flavonoid biosynthesis was hereby established. 展开更多
关键词 Flavonoids biosynthesis Phytohormone Transcription factor Non-coding RNAs Regulation network Fruit
暂未订购 下载PDF
Boosting genome editing of non-coding sequences in plants with glycosylase-mediated multi-nucleotide deletion editors 认领 引用
3
作者 Shanyue Liao Yao He +6 位作者 Guanqing Liu Yangcun Li Xu Tang Xuelian Zheng Yiping Qi Tao Zhang Yong Zhang 《Science Bulletin》 SCIE EI CAS CSCD 2026年第12期3032-3045,共14页
Compared with protein-coding sequences,non-coding sequences-such as promoters,untranslated regions(UTRs),microRNAs,and other regulatory ncRNAs-constitute the vast majority of the plant genome.They serve as critical re... Compared with protein-coding sequences,non-coding sequences-such as promoters,untranslated regions(UTRs),microRNAs,and other regulatory ncRNAs-constitute the vast majority of the plant genome.They serve as critical regulators of gene expression and therefore represent promising targets for crop improvement.However,their study and manipulation remain challenging due to the lack of efficient tools for generating large genomic deletions.Here,we report that CRISPR-Cas9-based glycosylase base editors(gBEs)function primarily as highly efficient multi-nucleotide deletion editors(gMDEs)in plants,a role distinct from their predominant base-editing activity in mammals.This functio nal shift is likely driven by a preferential AP lyase repair pathway for glycosylase-generated abasic sites(apurinic/apyrimidinic or AP sites)in plant cells.Unlike its parental system,CRISPR-Cas9,gMDEs efficiently generate 6-20 bp deletions across protospacers in both rice and soybean.We demonstrate their versatility by generating a continuum of plant height variation through promoter editing of OsD18 and boosting grain size by disrupting regulatory elements in both the 5'and 3'UTRs of OsGLW7,which function through distinct regulatory mechanisms.This work establishes gMDEs as a versatile and precise genome editing platform for inducing multi-nucleotide deletions in plants,making them efficient tools for genetic perturbation,especially of non-coding sequences. 展开更多
关键词 CRISPR-Cas Glycosylase Multi-nucleotide deletion Non-coding sequences editing Plant
暂未订购 下载PDF
Decoding the complexity of coding and non-coding RNAs across maize anther development at the isoform level 认领 引用
4
作者 Ge Yan Xuxu Ma +5 位作者 Wei Huang Chunyu Wang Yingjia Han Shufang Wang Han Liu Mei Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第1期163-176,共14页
Anther is a key male reproductive organ that is essential for the plant life cycle,from the sporophyte to the gametophyte generation.To explore the isoform-level transcriptional landscape of developing anthers in maiz... Anther is a key male reproductive organ that is essential for the plant life cycle,from the sporophyte to the gametophyte generation.To explore the isoform-level transcriptional landscape of developing anthers in maize(Zea mays L.),we analyzed Iso-Seq data from anthers collected at 10 developmental stages,together with strand-specific RNA-seq,CAGE-seq,and PAS-seq data.Of the 152,026 high-confidence full-length isoforms identified,68.8%have not been described;these include 22,365 isoforms that originate from previously unannotated loci and 82,167 novel isoforms that originate from annotated protein-coding genes.Using our newly developed strategy to detect dynamic expression patterns of isoforms,we identify 13,899 differentially variable regions(DVRs);surprisingly,1275 genes contain more than two DVRs,revealing highly efficient utilization of limited genic regions.We identify 7876 long non-coding RNAs(lncRNAs)from 4098 loci,most of which were preferentially expressed during cell differentiation and meiosis.We also detected 371 long-range interactions involving intergenic lncRNAs(lincRNAs);interestingly,243 were lincRNA-gene ones,and the interacting genes were highly expressed in anthers,suggesting that many potential lncRNA regulators of key genes are required for anther development.This study provides valuable resources and fundamental information for studying the essential transcripts of key genes during anther development. 展开更多
关键词 Anther development Long-read transcriptome sequencing Isoform Long non-coding RNA Maize
暂未订购 下载PDF
A DNA Damage-responsive Long Non-coding RNA lnc-DUSP6 Promotes Cisplatin-induced DNA Damage Repair and Chemoresistance 认领 引用
5
作者 XU Shun WU Wei-Jia +8 位作者 YANG Hai-Qing HUANG Hai-Jiao YE Li-Wen ZHU Yue SHEN Jia-En ZHENG Xiao-Li HUANG Xiao-Lu SHEN Han-Lian LI Yu-Ting 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2026年第2期295-307,共13页
Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful... Genomic destabilization and defective DNA repair are the most prominent features of tumour cells and are exploited by various chemotherapy drugs for cancer therapy.Long non-coding RNA(lncR-NAs)have emerged as powerful regulators of gene expression and are thus involved in diverse biological processes.Recent studies have demonstrated that several lncRNAs play critical roles in DNA repair.Nonetheless,the relationship between DNA damage-responsive lncRNAs and chemoresistance remains poorly defined.In this study,we established four different DNA damage models triggered by cisplatin(DDP),H2O2,neocarzinostatin(NCS)or ultraviolet(UV)irradiation and identified a specific upregu-lated lncRNA(lnc-DUSP6)involved in the cisplatin-induced DNA damage response.Furthermore,loss-or gain-of-function experiments confirmed that lnc-DUSP6 enhanced DNA repair and cell survival under cisplatin treatment,thus promoting cisplatin resistance.Mechanistically,an RNA immunoprecipitation(RIP)assay revealed that lnc-DUSP6 directly interacts with DUSP6(Dual Specificity Phosphatase 6),which is closely associated with cisplatin sensitivity.Additionally,overexpression of DUSP6 significantly rescued the effects of lnc-DUSP6 silencing on DNA repair and cell survival under cisplatin treatment.O-verall,our results show the effect and underlying mechanism of lnc-DUSP6 in cisplatin resistance:lnc-DUSP6 promotes cisplatin-induced DNA damage repair and cisplatin resistance by stabilizing DUSP6,which is highly clinically important for enhancing the efficacy of cisplatin for cancers. 展开更多
关键词 long non-coding RNA(lncRNAs) chemoresistance dual specificity protein phosphatase 6(DUSP6) lnc-DUSP6 DNA damage response(DDR)
暂未订购 下载PDF
Novel insights into non-coding RNAs and their role in hydrocephalus 认领 引用
6
作者 Zhiyue Cui Jian He +8 位作者 An Li Junqiang Wang Yijian Yang Kaiyue Wang Zhikun Liu Qian Ouyang Zhangjie Su Pingsheng Hu Gelei Xiao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期636-647,共12页
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog... A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus,one of the most common neurological conditions worldwide.In this review,we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition.Then,we outline the definition,classification,and biological role of non-coding RNAs.Subsequently,we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail.Specifically,we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus,including glymphatic pathways,neuroinflammatory processes,and neurological dysplasia,on the basis of the existing evidence.Lastly,we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments. 展开更多
关键词 hydrocephalus neurodevelopment neuroinflammation non-coding RNA therapeutic target
暂未订购 下载PDF
Non-coding RNA in extracellular vesicles and the occurrence and progression of psychiatric disorders:A narrative review 认领 引用
7
作者 Yang Cao Peng-Fei Li +2 位作者 Lin Zhu Ke Li Kuan-Jun He 《World Journal of Psychiatry》 SCIE 2026年第2期31-44,共14页
As the role of non-coding RNAs(ncRNAs)in psychiatric disorders gains increasing prominence,attention has shifted to their dysregulated expression in these conditions.Extracellular vesicles(EVs),particularly exosomes,p... As the role of non-coding RNAs(ncRNAs)in psychiatric disorders gains increasing prominence,attention has shifted to their dysregulated expression in these conditions.Extracellular vesicles(EVs),particularly exosomes,play a crucial role as key mediators of cellular communication within the brain and between peripheral tissues.Their influence on neurogenesis,synaptic plasticity,and neuronal stress responses underscores their significance in psychopathophysiology.Due to their stability,disease-specific expression,and functional roles,EV-encapsulated ncRNAs have emerged as highly promising biomarkers.This review systematically explores the interactions between EV-derived ncRNAs and psychiatric disorders,evaluating their diagnostic potential and therapeutic applications in the field of psychiatry. 展开更多
关键词 Non-coding RNA Extracellular vesicles Psychiatric disorders Relationship Psychiatry
暂未订购 下载PDF
RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma:Hidden Treasures in Plain Sight 认领 引用
8
作者 Se Ha Jang Hyung Seok Kim Jung Woo Eun 《Oncology Research》 SCIE 2026年第1期89-104,共16页
Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functi... Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy. 展开更多
关键词 Hepatocellular carcinoma long non-coding RNA RP11-derived lncRNA biomarker therapeutic target
暂未订购 下载PDF
Helicobacter pylori-related non-coding RNAs in gastric cancer screening:Emerging evidence and translational challenges 认领 引用
9
作者 Zuo-Po Lv Muhammad Haris Sultan Yi-Gang Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第1期1-7,共7页
Gastric cancer(GC)has high morbidity and mortality worldwide.Due to the absence of noticeable symptoms,diagnosing GC at an early stage is very difficult,which consequently leads to advanced GC and poor prognosis.Effec... Gastric cancer(GC)has high morbidity and mortality worldwide.Due to the absence of noticeable symptoms,diagnosing GC at an early stage is very difficult,which consequently leads to advanced GC and poor prognosis.Effective biomarkers are essential for prolonging patients’survival.Helicobacter pylori(H.pylori)infection represents the most significant risk factor for GC,with nearly all cases linked to this infection.Many non-coding RNAs(ncRNAs)are dysregulated in H.pylori-infected GC,indicating that ncRNAs may serve as biomarkers of early-stage GC.In this editorial,we discuss the study by Chen et al.Although previous studies have identified roles for miR-136 in gastric cancer proliferation,apoptosis,and invasion,none have specifically explored its relationship with H.pylori-associated gastric carcinogenesis. 展开更多
关键词 Helicobacter pylori Gastric cancer Non-coding RNA Biomarker Clinical challenges
暂未订购 下载PDF
Long non-coding RNAs:Emerging regulators of diverse programmed cell death pathways in neurons 认领 引用
10
作者 Noah C.Mathew Kevin K.Park 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4020-4027,共8页
Long non-coding RNAs have emerged as pivotal regulators of diverse biological processes,particularly in the modulation of regulated neuronal cell death pathways.This review highlights the roles of long non-coding RNAs... Long non-coding RNAs have emerged as pivotal regulators of diverse biological processes,particularly in the modulation of regulated neuronal cell death pathways.This review highlights the roles of long non-coding RNAs in programmed neuronal cell death,focusing on apoptosis,necroptosis,ferroptosis,and pyroptosis.Dysregulation of these processes contributes to neurodegenerative disorders and neurological injuries,emphasizing the importance of understanding how long non-coding RNAs influence these pathways.Apoptosis,essential for neuronal development,can lead to pathology when misregulated.Necroptosis,a caspase-independent inflammatory process,involves the modulation of necrosome components.Pyroptosis,mediated by inflammasomes,affects inflammasome assembly and cytokine release.Ferroptosis,driven by iron accumulation and lipid peroxidation,is influenced by changes in antioxidant defenses.By detailing the roles of long non-coding RNAs in these mechanisms,this review underscores their therapeutic potential for mitigating neuronal loss. 展开更多
关键词 apoptosis lncRNA necroptosis neuronal death non-coding RNA
暂未订购 下载PDF
Non-coding RNAs in acute ischemic stroke:from brain to periphery 认领 引用 被引量：5
11
作者 Shuo Li Zhaohan Xu +7 位作者 Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第1期116-129,共14页
Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic ... Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined.With innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models.Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic stroke.Moreover,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.In particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke.In this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke. 展开更多
关键词 acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress
暂未订购 下载PDF
Roles of autophagy and long non-coding RNAs in gastric cancer 认领 引用 被引量：1
12
作者 Thang Viet Luong Mai Thi Thu Cao +2 位作者 Nam Van Duc Nguyen Hai Nguyen Ngoc Dang Trung Tran Nguyen 《World Journal of Gastroenterology》 SCIE CAS 2025年第11期198-206,共9页
Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet c... Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet complex roles in GC,functioning as both tumor suppressors and promoters depending on the disease stage and context.Autophagy influences cellular homeostasis and metabolism,whereas lncRNAs regulate gene expression through epigenetic modifications,RNA sponging,and protein interactions.Notably,the interplay between lncRNAs and autophagy modulates tumor progression,metastasis,chemoresistance,and the tumor microenvironment.This study explored the intricate relationship between lncRNAs and autophagy in GC,highlighting their roles in pathogenesis and treatment resistance.By addressing current knowledge gaps and proposing innovative therapeutic strategies,we have emphasized the potential of targeting this dynamic interplay for improved diagnostic and therapeutic outcomes. 展开更多
关键词 Autophagy Gastrointestinal cancer Gastric cancer Long non-coding RNAs Cancer progression Epigenetic
暂未订购 下载PDF
Mechanisms underlying hepatocellular carcinoma progression through N6-methyladenosine modifications of long non-coding RNA 认领 引用 被引量：1
13
作者 Ning Wang Fei-Tian Min +1 位作者 Wei-Bo Wen Huan-Tian Cui 《World Journal of Gastroenterology》 SCIE CAS 2025年第21期135-139,共5页
Hepatocellular carcinoma(HCC)is a highly lethal malignancy with limited treatment options,particularly for patients with advanced stages of the disease.Sorafenib,the standard first-line therapy,faces significant chall... Hepatocellular carcinoma(HCC)is a highly lethal malignancy with limited treatment options,particularly for patients with advanced stages of the disease.Sorafenib,the standard first-line therapy,faces significant challenges due to the development of drug resistance.Yu et al explored the mechanisms by which lncRNA KIF9-AS1 regulates the stemness and sorafenib resistance in HCC using a combination of cell culture,transfection,RNA immunoprecipitation,co-immunoprecipitation,and xenograft tumor models.They demonstrate that N6-methyladenosine-modified long non-coding RNA KIF9-AS1 acts as an oncogene in HCC.This modification involves methyltransferase-like 3 and insulin-like growth factor 2 mRNA-binding protein 1,which play critical roles in regulating KIF9-AS1.Furthermore,KIF9-AS1 stabilizes and upregulates short stature homeobox 2 by promoting its deubiquitination through ubiquitin-specific peptidase 1,thereby enhancing stemness and contributing to sorafenib resistance in HCC cells.These findings provide a theoretical basis for KIF9-AS1 as a diagnostic marker and therapeutic target for HCC,highlighting the need for further investigation into its clinical application potential. 展开更多
关键词 Hepatocellular carcinoma Stemness Sorafenib resistance Long non-coding RNA KIF9-AS1 Short stature homeobox 2 N6-methyladenosine
暂未订购 下载PDF
Immune cell-derived exosomal non-coding RNAs in tumor microenvironment:Biological functions and potential clinical applications 认领 引用
14
作者 Chenguang Liu Yawen Luo +3 位作者 Huan Zhou Meixi Lin Dan Zang Jun Chen 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2025年第2期250-267,共18页
The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy.Within the tumor microenvironment,exosomes have emerged as pivotal mediators of inte... The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy.Within the tumor microenvironment,exosomes have emerged as pivotal mediators of intercellular communication,with their cargo of non-coding RNAs(ncRNAs)serving as key regulatory elements.This review examines the multifaceted roles of immune cell-derived exosomal ncRNAs in tumor biology.The involvement of various immune cells,including T cells,B cells,natural killer cells,macrophages,neutrophils,and myeloid-derived suppressor cells,in utilizing exosomal ncRNAs to regulate tumor initiation and progression is explored.Additionally,the biogenesis and delivery mechanisms of these immune cell-derived exosomal ncRNAs are discussed,alongside their potential clinical applications in cancer. 展开更多
关键词 Tumor immune exosome non-coding RNAs clinical applications
暂未订购 下载PDF
Exosomal Non-Coding RNAs in Pancreatic Cancer:From Mechanisms to Clinical Applications 认领 引用
15
作者 Chengru Yang Zhiyu Wang +7 位作者 Shaowu Bi Xinmiao Zhang Zhaoqiang Xu Yifei Ge Tianjie Zhang Nan Wang Yi Xu Xiangyu Zhong 《Oncology Research》 SCIE 2025年第11期3207-3229,共23页
Pancreatic cancer(PC)is an extremely aggressive cancer of the digestive system with insidious onset and the lack of effective biomarkers,resulting in late-stage diagnosis and poor prognosis.Exosomal non-coding RNAs(nc... Pancreatic cancer(PC)is an extremely aggressive cancer of the digestive system with insidious onset and the lack of effective biomarkers,resulting in late-stage diagnosis and poor prognosis.Exosomal non-coding RNAs(ncRNAs)are key mediators of intercellular communication that drive PC initiation and advancement.By modulating gene expression,they impact tumor microenvironment(TME)remodeling,proliferation,migration,apoptosis,and immune evasion.Critically,exosomal ncRNAs serve as promising biomarkers for early diagnosis and prognostic assessment.This review summarizes the current research achievements regarding exosomal ncRNAs in PC,systematically elaborating on their roles in tumor occurrence,metastasis,chemoresistance and the TME.Furthermore,by integrating the potential of exosomal ncRNAs in the diagnosis,treatment and prognosis of PC and by highlighting the challenges and future directions,this review aims to offer novel insights for future research and clinical translation of exosomal ncRNAs in PC. 展开更多
关键词 Exosomes non-coding RNAs pancreatic cancer biomarker diagnosis therapy
暂未订购 下载PDF
Massively parallel characterization of non-coding de novo mutations in autism spectrum disorder 认领 引用
16
作者 Congcong Chen Songwei Guo +13 位作者 Yanan Shi Xinyu Gu Ziye Xu Yingjia Chen Yayun Gu Na Qin Yue Jiang Juncheng Dai Yuanlin He Xiao Han Yan Liu Zhibin Hu Xiaoyan Ke Cheng Wang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第10期1246-1258,共13页
Autism spectrum disorder(ASD)is a neurodevelopmental disorder where de novo mutations play a significant role.Although coding mutations in ASD have been extensively characterized,the impact of non-coding de novo mutat... Autism spectrum disorder(ASD)is a neurodevelopmental disorder where de novo mutations play a significant role.Although coding mutations in ASD have been extensively characterized,the impact of non-coding de novo mutations(ncDNMs)remains less understood.Here,we integrate cortex cell-specific cis-regulatory element annotations,a deep learning-based variant prediction model,and massively parallel reporter assays to systematically evaluate the functional impact of 227,878 ncDNMs from Simons Simplex Collection(SSC)and Autism Speaks MSSNG resource(MSSNG)cohorts.Our analysis identifies 238 ncDNMs with confirmed functional regulatory effects,including 137 down-regulated regulatory mutations(DrMuts)and 101 up-regulated regulatory mutations(UrMuts).Subsequent association analyses reveal that only DrMuts regulating loss-of-function(LoF)intolerant genes rather than other ncDNMs are significantly associated with the risk of ASD(Odds ratio=4.34;P=0.001).A total of 42 potential ASD-risk DrMuts across 41 candidate ASD-susceptibility genes are identified,including 12 recognized and 29 unreported genes.Interestingly,these noncoding disruptive mutations tend to be observed in genes extremely intolerant to LoF mutations.Our study introduces an optimized approach for elucidating the functional roles of ncDNMs,thereby expanding the spectrum of pathogenic variants and deepening our understanding of the complex molecular mechanisms underlying ASD. 展开更多
关键词 Autism spectrum disorder Non-coding de novo mutations Massively parallel reporterassay High-throughput screening Loss-of-function intolerant gene
暂未订购 下载PDF
Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis 认领 引用
17
作者 Ying-Jie Wang Zhong-Zheng Zhi +2 位作者 Tao Liu Jian Kang Guang-Hui Xu 《World Journal of Orthopedics》 2025年第5期80-92,共13页
BACKGROUND Spinal cord injury(SCI)is a severe and permanent trauma that often leads to significant motor,sensory,and autonomic dysfunction.Neuronal apoptosis is a major pathomechanism underlying secondary injury in SC... BACKGROUND Spinal cord injury(SCI)is a severe and permanent trauma that often leads to significant motor,sensory,and autonomic dysfunction.Neuronal apoptosis is a major pathomechanism underlying secondary injury in SCI.Long non-coding RNAs(lncRNAs)have emerged as key regulators of gene expression and cellular processes,including apoptosis.However,the role of lncRNA growth arrest-specific transcript 5(GAS5)in SCI-induced neuronal apoptosis remains unclear.AIM To investigate the role of lncRNA GAS5 in SCI-induced neuronal apoptosis via its interaction with microRNA(miR)-21 and the phosphatase and tensin homolog(PTEN)/AKT pathway.METHODS SCI rat models and hypoxic neuronal cell models were established.Motor function was assessed using the Basso-Beattie-Bresnahan score.Expression levels of GAS5,miR-21,PTEN,caspase 3,B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(Bax),and AKT were measured using quantitative PCR or Western blot analysis.Neuronal apoptosis was determined by TUNEL staining.Dual-luciferase reporter assays validated GAS5-miR-21 binding.Knockdown and overexpression experiments explored the functional effects of the GAS5/miR-21 axis.RESULTS GAS5 was significantly upregulated in the spinal cord following SCI,coinciding with increased neuronal apoptosis and decreased AKT activation.In vitro experiments demonstrated that GAS5 acted as a molecular sponge for miR-21,leading to increased PTEN expression and inhibition of the AKT signaling pathway,thereby promoting apoptosis.In vivo,GAS5 knockdown attenuated neuronal apoptosis,enhanced AKT activation,and improved motor function recovery in SCI rats.CONCLUSION GAS5 promotes neuronal apoptosis in SCI by binding to miR-21 and upregulating PTEN expression,inhibiting the AKT pathway.Targeting GAS5 may represent a novel therapeutic strategy for SCI. 展开更多
关键词 Spinal cord injury Long non-coding RNA Growth arrest-specific transcript 5 MicroRNA-21 Neuronal apoptosis
暂未订购 下载PDF
Non-coding RNAs as potential mediators of resistance to lung cancer immunotherapy and chemotherapy 认领 引用 被引量：1
18
作者 JIAHUI WANG HONGCHENG GE +1 位作者 ZHENGYUAN YU LINGZHI WU 《Oncology Research》 SCIE 2025年第5期1033-1054,共22页
Lung cancer is a common cause of cancer-related death globally.The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy.However,as the treatment cycle progresses and the disease evolv... Lung cancer is a common cause of cancer-related death globally.The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy.However,as the treatment cycle progresses and the disease evolves,the emergence of acquired resistance leads to treatment failure.Many researches have shown that non-coding RNAs(ncRNAs)not only influence lung cancer progression but also act as potential mediators of immunotherapy and chemotherapy resistance in lung cancer,mediating drug resistance by regulating multiple targets and pathways.In addition,the regulation of immune response by ncRNAs is dualistic,forming a microenvironment for inhibits/promotes immune escape through changes in the expression of immune checkpoints.The aim of this review is to understand the effects of ncRNAs on the occurrence and development of lung cancer,focusing on the role of ncRNAs in regulating drug resistance of lung cancer. 展开更多
关键词 Non-coding RNAs(ncRNAs) Lung cancer Drug resistance Immunotherapy Chemotherapy Immune checkpoints Immune escape
暂未订购 下载PDF
Regulation of matrix metalloproteinase-13 in cancer:Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting 认领 引用 被引量：1
19
作者 Deekshaa Chidambaram Velan Subashini +2 位作者 Muthuvairaprasath Nanthanalaxmi Iyyappan Saranya Nagarajan Selvamurugan 《World Journal of Clinical Oncology》 2025年第6期64-79,共16页
Matrix metalloproteinases(MMPs)are essential enzymes involved in extracellular matrix degradation and remodeling.Such processes are integral to normal tissue homeostasis and several pathological conditions such as can... Matrix metalloproteinases(MMPs)are essential enzymes involved in extracellular matrix degradation and remodeling.Such processes are integral to normal tissue homeostasis and several pathological conditions such as cancer.Among these MMPs,MMP-13 plays a key role in cancer progression,driving tumor invasion,metastasis,and angiogenesis.Despite significant advancements in understanding its biology,therapeutic targeting of MMP-13 remains challenging owing to its complex and multifaceted regulatory mechanisms.Recent studies have underscored the pivotal role of non-coding RNAs(ncRNAs),including long ncRNAs,microRNAs,and circular RNAs,in modulating MMP-13 expression.This review provides a comprehensive analysis of MMP-13 regulation by several signaling pathways,the influence of ncRNAs on these signaling pathways,and MMP-13 expression during cancer progression and metastasis.Furthermore,we explored the clinical relevance of ncRNA-mediated regulatory networks,highlighting their potential as diagnostic biomarkers and therapeutic targets in various cancers.By unraveling these regulatory mechanisms,this review offers valuable insights into innovative strategies for cancer diagnosis and treatment and emphasizes the translational significance of ncRNA-mediated MMP-13 regulation in oncology. 展开更多
关键词 Matrix metalloproteinase-13 Cancer MicroRNAs Long non-coding RNAs Circular RNAs
暂未订购 下载PDF
Role of mesenchymal stem cell-derived exosomal non-coding RNAs in bone and bone-related disorders 认领 引用 被引量：1
20
作者 Deekshaa Chidambaram Velan Subashini +1 位作者 Muthuvairaprasath Nanthanalaxmi Nagarajan Selvamurugan 《World Journal of Stem Cells》 SCIE 2025年第10期56-67,共12页
Mesenchymal stem cells(MSCs)are known for their ability to differentiate into various cell lineages,including osteoblasts(bone-forming cells),and for their significant paracrine effects.Among their secreted products,e... Mesenchymal stem cells(MSCs)are known for their ability to differentiate into various cell lineages,including osteoblasts(bone-forming cells),and for their significant paracrine effects.Among their secreted products,exosomes have gained considerable attention as nanoscale carriers of bioactive molecules such as non-coding RNAs(ncRNAs).These ncRNAs,including microRNAs,long ncRNAs,and circular ncRNAs,are critical regulators of gene expression and cellular functions.Moreover,MSC-derived exosomes not only offer advantages such as targeted delivery,reduced immunogenicity,and protection of cargo material,but also carry ncRNAs that have therapeutic and diagnostic potential in bone-related disorders.Emerging evidence has highlighted the role of MSC-derived exosomal ncRNAs in osteogenesis,bone remodeling,and intercellular signaling in the bone microenvironment.This review consolidates recent research on the role of MSC-derived exosomal ncRNAs in maintaining bone homeostasis and bone-related disorders via various signaling pathways and epigenetic modifications.Furthermore,we explore the therapeutic potential of MSC-derived exosomal ncRNAs as biomarkers and therapeutic targets.This comprehensive review offers key insights into the regulatory roles of MSC-derived exosomal ncRNAs in bone biology and their clinical significance in bone-related diseases. 展开更多
关键词 Mesenchymal stem cell-derived exosomes Non-coding RNAs Bone disorders Bone homeostasis Signaling pathway
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 24 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈