期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到278篇文章
< 1 2 … 14 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
A call for coordinated action on problematic papers in noncoding RNA research 认领 引用
1
作者 Ying Lou Zhengyi Zhou +1 位作者 Zhesi Shen Menghui Li 《Zoological Research》 SCIE CSCD 2026年第2期375-377,共3页
Non-coding RNAs(ncRNAs)have emerged as major regulators of a wide range of biological processes and have attracted considerable attention as promising targets and tools for disease diagnosis and therapy(Nemeth et al.,... Non-coding RNAs(ncRNAs)have emerged as major regulators of a wide range of biological processes and have attracted considerable attention as promising targets and tools for disease diagnosis and therapy(Nemeth et al.,2024).However,the rapid expansion of this field,driven in part by the vast number of ncRNAs that remain insufficiently characterized,has also created opportunities for the proliferation of potentially fraudulent studies(Byrne et al.,2019).As a result,ncRNA research has become one of the scientific areas most heavily affected by paper mill activity.More than 2100 ncRNA-related articles have been retracted due to academic misconduct,with the retraction rate in this field reaching 1.41%,approximately 20 times higher than the global retraction rate of 0.068%(Li&Shen,2024). 展开更多
关键词 paper mill activity academic misconduct disease diagnosis therapy disease diagnosis therapy nemeth noncoding RNAs biological processes retraction
暂未订购 下载PDF
Retraction:Long Noncoding RNA PVT1 Promotes Melanoma Progression via Endogenous Sponging miR-26b 认领 引用
2
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2026年第3期766-766,共1页
The published article titled“Long Noncoding RNA PVT1 PromotesMelanoma Progression via Endogenous Sponging miR-26b”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.675–681.DOI:10.3727/096504017X14920318... The published article titled“Long Noncoding RNA PVT1 PromotesMelanoma Progression via Endogenous Sponging miR-26b”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.675–681.DOI:10.3727/096504017X14920318811730 URL:http://gffzz9e48629005df441asvk5nk5nxc9wf6vnn.ffgz.tsg.suse.edu.cn/or/v26n5/56680 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases. 展开更多
关键词 cellular datawhere protein bands cellular data PVT long noncoding RNA melanoma miR b western blot
暂未订购 下载PDF
Retraction:Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451 认领 引用
3
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2026年第6期782-782,共1页
The published article titled“Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451”has been retracted from Oncology Research,Vol.25,No.7,2017,pp.1207–1214.DOI:10.3727/096504017X14886... The published article titled“Long Noncoding RNA CRNDE Promotes Multiple Myeloma Cell Growth by Suppressing miR-451”has been retracted from Oncology Research,Vol.25,No.7,2017,pp.1207–1214.DOI:10.3727/096504017X14886679715637 URL:http://gffzz9e48629005df441asvk5nk5nxc9wf6vnn.ffgz.tsg.suse.edu.cn/or/v25n7/56905 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells. 展开更多
关键词 cellular datawhere multiple myeloma miR CRNDE long noncoding RNA cell growth multiple myeloma cell figure similarity
暂未订购 下载PDF
Retraction:Long Noncoding RNA GAS5 Inhibits Tumorigenesis and Enhances Radiosensitivity by Suppressing miR-135b Expression in Non-Small Cell Lung Cancer 认领 引用
4
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2026年第6期781-781,共1页
The published article titled“Long Noncoding RNA GAS5 Inhibits Tumorigenesis and Enhances Radiosensitivity by Suppressing miR-135b Expression in Non-Small Cell Lung Cancer”has been retracted from Oncology Research,Vo... The published article titled“Long Noncoding RNA GAS5 Inhibits Tumorigenesis and Enhances Radiosensitivity by Suppressing miR-135b Expression in Non-Small Cell Lung Cancer”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1305–1316.DOI:10.3727/096504017X14850182723737 URL:http://gffzz9e48629005df441asvk5nk5nxc9wf6vnn.ffgz.tsg.suse.edu.cn/or/v25n8/56915 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases. 展开更多
关键词 tumorigenesis cellular datawhere non small cell lung cancer enhances radiosensitivity long noncoding RNA GAS inhibits tumorigenesis radiosensitivity
暂未订购 下载PDF
Retraction:Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer by Upregulating miR-613 认领 引用
5
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2026年第3期767-767,共1页
The published article titled“Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis andMetastasis of Non-Small Cell Lung Cancer by Upregulating miR-613”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.... The published article titled“Long Noncoding RNA(lncRNA)HOTAIR Affects Tumorigenesis andMetastasis of Non-Small Cell Lung Cancer by Upregulating miR-613”has been retracted from Oncology Research,Vol.26,No.5,2018,pp.725–734.DOI:10.3727/096504017X15119467381615 URL:http://gffzz9e48629005df441asvk5nk5nxc9wf6vnn.ffgz.tsg.suse.edu.cn/or/v26n5/56685 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases. 展开更多
关键词 non small cell lung cancer cellular datawhere Hotair metastasis long noncoding RNA tumorigenesis western blot miR
暂未订购 下载PDF
Retraction:Long Noncoding RNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation and Invasion in Gastric Cancer via Negatively Modulating miRNA-145-5p 认领 引用
6
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2026年第7期741-741,共1页
The published article titled“Long Noncoding RNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation and Invasion in Gastric Cancer via Negatively Modulating miRNA-145-5p”has been retracted from Oncology Research,... The published article titled“Long Noncoding RNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation and Invasion in Gastric Cancer via Negatively Modulating miRNA-145-5p”has been retracted from Oncology Research,Vol.25,No.5,2017,pp.789–798. 展开更多
关键词 taurine upregulated gene cell invasion gastric cancer long noncoding rna cell proliferation microRNA p
暂未订购 下载PDF
Profiling and functional characterization of long noncoding RNAs during human tooth development 认领 引用 被引量：2
7
作者 Xiuge Gu Wei Wei +11 位作者 Chuan Wu Jing Sun Xiaoshan Wu Zongshan Shen Hanzhang Zhou Chunmei Zhang Jinsong Wang Lei Hu Suwen Chen Yuanyuan Zhang Songlin Wang Ran Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第4期505-516,共12页
The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understoo... The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understood.In this research,we examined the lncRNAs present in the dental epithelium(DE)and dental mesenchyme(DM)at the late bud,cap,and early bell stages of human fetal tooth development through bulk RNA sequencing.Developmental regulators co-expressed with neighboring lncRNAs were significantly enriched in odontogenesis.Specific lncRNAs expressed in the DE and DM,such as PANCR,MIR205HG,DLX6-AS1,and DNM3OS,were identified through a combination of bulk RNA sequencing and single-cell analysis.Further subcluster analysis revealed lncRNAs specifically expressed in important regions of the tooth germ,such as the inner enamel epithelium and coronal dental papilla(CDP).Functionally,we demonstrated that CDP-specific DLX6-AS1 enhanced odontoblastic differentiation in human tooth germ mesenchymal cells and dental pulp stem cells.These findings suggest that lncRNAs could serve as valuable cell markers for tooth development and potential therapeutic targets for tooth regeneration. 展开更多
关键词 long noncoding RNAs dental mesenchyme developmental biology dental mesenchyme dm dental epithelium de bulk rna sequencingdevelopmental regulators human tooth development tooth development
暂未订购 下载PDF
Long noncoding RNA semaphorin 6A-antisense RNA 1 reduces hepatocellular carcinoma by promoting semaphorin 6A mRNA degradation 认领 引用 被引量：2
8
作者 Song-Man Yu Min Zhang +4 位作者 Sha-Lin Li Si-Ya Pei Li Wu Xing-Wang Hu Yan-Kun Duan 《World Journal of Gastroenterology》 SCIE CAS 2025年第13期138-151,共14页
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignant tumor with a poor prognosis,which is often associated with chronic hepatitis B virus infection in China.Our previous study has shown that long non-codin... BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignant tumor with a poor prognosis,which is often associated with chronic hepatitis B virus infection in China.Our previous study has shown that long non-coding RNA semaphorin 6Aantisense RNA 1(SEMA6A-AS1)was significantly downregulated in hepatitis B virus-related HCC and associated with poor prognosis.AIM To explore the underlying mechanism of SEMA6A-AS1 in HCC progression.METHODS The expression levels of SEMA6A-AS1 and SEMA6A were detected using quantitative polymerase chain reaction,immunohistochemistry and Western blot.A growth curve,colony formation,wound-healing and transwell(with or without Matrigel)assays were respectively performed to assess the proliferation,migration and invasion abilities of HCC cells.Cell cycle and apoptosis assays were performed by flow cytometry.To investigate the potential mechanism underpinning SEMA6A-AS1,we utilized tagged RNA affinity purification,dual luciferase reporter assay and immunofluorescence.RESULTS Downregulation of SEMA6A-AS1 in HCC was negatively correlated with SEMA6A protein expression.SEMA6A was upregulated in HCC and correlated with high alpha-fetoprotein level,high Edmondson-Steiner grade and poor prognosis.SEMA6A-AS1 significantly inhibited the proliferation,migration and invasion of HCC cells by combining with SEMA6A mRNA and promoting its degradation.SEMA6A protein promoted the proliferation,migration and invasion of HCC cells by regulating the actin cytoskeleton.CONCLUSION Our findings suggest that SEMA6A-AS1 can inhibit HCC progression through decreasing SEMA6A expression by promoting its mRNA degradation.SEMA6A-AS1 may be a prognostic biomarker and therapeutic target for HCC. 展开更多
关键词 Long noncoding RNA Semaphorin 6A antisense RNA 1 Semaphorin 6A Hepatocellular carcinoma Liver cancer
暂未订购 下载PDF
Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis 认领 引用
9
作者 Bin Wang Qian Zhou +7 位作者 Cui-E Cheng Yi-Jie Gu Ting-Wang Jiang Jia-Ming Qiu Gui-Ning Wei Ya-Dong Feng Li-Hua Ren Rui-Hua Shi 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第5期278-292,共15页
BACKGROUND Colorectal cancer(CRC)is the second most prevalent cause of cancer-related mortality and is increasing in younger individuals.Chemotherapy,a crucial adjuvant systemic therapy for CRC management,often leads ... BACKGROUND Colorectal cancer(CRC)is the second most prevalent cause of cancer-related mortality and is increasing in younger individuals.Chemotherapy,a crucial adjuvant systemic therapy for CRC management,often leads to resistance through poorly characterized underlying molecular mechanisms.The long noncoding RNA SNHG5 is highly expressed in CRC and promotes tumor proliferation and invasion,prompting us to hypothesize that SNHG5 may play a crucial role in the chemotherapeutic agent 5-fluorouracil(5-Fu)resistance in CRC.AIM To identify the function and mechanism of SNHG5 in 5-Fu resistance in CRC.METHODS Quantitative real-time polymerase chain reaction was performed to examine the expression of SNHG5 in CRC tissues from 225-Fu-sensitive patients and 145-Fu-resistant patients and in CRC cells and 5-Fu-resistant CRC cells.Cell viability and apoptosis were assessed in SNHG5-overexpressing CRC cells and SNHG5-knockdown 5-Furesistant CRC cells.SNHG5 function in 5-Fu resistance in CRC was further analyzed using a xenograft mouse model.SNHG5 interactions with microRNAs were predicted by bioinformatics analysis.Luciferase reporter and RNA immunoprecipitation assays were performed to verify the binding between SNHG5 and miR-26b.Rescue experiments were performed to validate the functional interaction between SNHG5 and the miR-26b/p-glycoprotein(Pgp)axis.RESULTS SNHG5 expression was upregulated in 5-Fu-resistant CRC tissues and 5-Fu-resistant CRC cells.In vitro functional experiments demonstrated that SNHG5 overexpression significantly reduced cell apoptosis and enhanced cell viability,whereas SNHG5 knockdown in 5-Fu-resistant CRC cells increased cell apoptosis and decreased cell viability upon 5-Fu treatment.In a xenograft mouse model,we confirmed that SNHG5 overexpression led to a reduction in 5-Fu sensitivity in CRC in vivo.Mechanistically,SNHG5 acted as a molecular sponge for miR-26b.Rescue experiments validated that SNHG5 conferred 5-Fu resistance in CRC by regulating the miR-26b/Pgp axis.CONCLUSION SNHG5/miR-26b/Pgp regulates CRC chemosensitivity,providing potential therapeutic targets for the treatment of 5-Fu-resistant CRC. 展开更多
关键词 SNHG5 5-fluorouracil resistance Colorectal cancer MiR-26b P-glycoprotein Long noncoding RNA Therapeutic target
暂未订购 下载PDF
Genome-wide identification and expression analysis of long noncoding RNAs in MdHYL1-mediated regulation of leaf development and water transport in apple 认领 引用
10
作者 Jiale Wen Jieqiang He +6 位作者 Heqiong Wang Zijian Liu Xiaoxia Shen Dali Geng Fengwang Ma Qingmei Guan Xuewei Li 《Fruit Research》 2025年第1期42-55,共14页
HYL1 serves as a central component of the miRNA processing machinery,playing a vital role in coordinating plant development and adaptation to environmental stresses.In apple,MdHYL1 knockdown impairs leaf development a... HYL1 serves as a central component of the miRNA processing machinery,playing a vital role in coordinating plant development and adaptation to environmental stresses.In apple,MdHYL1 knockdown impairs leaf development and water transport,though whether this regulation involves miRNA/lncRNA networks remains unclear.To elucidate the regulatory mechanisms underlying leaf development and water transport mediated by MdHYL1 in apple,transcriptome-wide profiling of lncRNAs,miRNAs,and mRNAs in wild-type GL-3 vs MdHYL1 RNAi transgenic plants were conducted.In total,28 lncRNAs and 813 mRNAs were detected as exhibiting significant differential expression,with lncRNAs predicted to regulate target mRNAs through cis-or trans-acting mechanisms.Functional annotation revealed these target genes to be enriched in flavonoid biosynthesis(MdMYB12,MdCHS),lignin metabolism(MdCYP98A3,MdMYB85),cell wall biogenesis/modification(MdNAC042,MdIRX1,MdIRX6),and water transport pathways(MdSIP1;1,MdTIP1;3,MdPIP2;5).RT-qPCR analysis further confirmed the co-expression networks between the identified mRNAs and lncRNAs.How MdHYL1 influences the regulatory functions of lncRNAs within the miRNA–mRNA–lncRNA network was subsequently examined.Members of the miR482,miR398,miR858,and miR2118 families were identifed as endogenous target mimics(eTMs)for specific lncRNAs.Notably,MSTRG.32670.1 may act as an eTM of miR166 to regulate MdCYP98A3,linking non-coding RNA regulation with lignin deposition and water transport.The present results uncover new mechanistic perspectives on how lncRNAs participate in MdHYL1-mediated regulation of leaf development and water transport in apple,while establishing a conceptual framework for future investigations of lncRNA functions in woody perennial crops. 展开更多
关键词 mirna processing regulatory mechanisms microRNAs MdHYL long noncoding RNAs water transport mRNA leaf development
暂未订购 下载PDF
Retraction:Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway 认领 引用
11
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2025年第10期3157-3157,共1页
The published article titled“Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway”has been retracted from Oncology Research... The published article titled“Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway”has been retracted from Oncology Research,Vol.26,No.1,2018,pp.131–143. 展开更多
关键词 prostate cancer MAPK pathway long noncoding rna Schlap miR proliferation metastasis
暂未订购 下载PDF
Retraction:Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells 认领 引用
12
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2025年第4期989-989,共1页
The published article titled“Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells”has been retracted from Oncology Research,Vol.26,N... The published article titled“Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells”has been retracted from Oncology Research,Vol.26,No.6,2018,pp.869–878. 展开更多
关键词 miR b PTENP cell migration long noncoding rna cell proliferation
暂未订购 下载PDF
Retraction: Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression in Non-Small Cell Lung Cancer 认领 引用
13
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2025年第9期2597-2597,共1页
The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI... The published article titled“Long Noncoding RNA GAS5 Suppresses Tumorigenesis by Inhibiting miR-23a Expression inNon-Small Cell Lung Cancer”has been retracted fromOncology Research,Vol.25,No.6,2017,pp.1027–1037.DOI:10.3727/096504016X14822800040451 URL:http://gffzz9e48629005df441asvk5nk5nxc9wf6vnn.ffgz.tsg.suse.edu.cn/or/v25n6/56885 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells. 展开更多
关键词 tumorigenesis cellular datawhere performed ex non small cell lung cancer long noncoding RNA GAS miR
暂未订购 下载PDF
Retraction: Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis 认领 引用
14
作者 Oncology Research Editorial Office 《Oncology Research》 SCIE 2025年第6期1509-1509,共1页
The published article titled“Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis”has been retracted from Oncology ... The published article titled“Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis”has been retracted from Oncology Research,Vol.28,No.1,2020,pp.65-73. 展开更多
关键词 esophageal squamous cell carcinoma foxd cisplatin resistance long noncoding rna mir akt mTOR axis
暂未订购 下载PDF
Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease 认领 引用 被引量：5
15
作者 Ying Bai Hui Ren +6 位作者 Liang Bian You Zhou Xinping Wang Zhongli Xiong Ziqi Liu Bing Han Honghong Yao 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第3期440-452,共13页
Non-coding RNAs(ncRNAs)are a class of functional RNAs that play critical roles in different diseases.NcRNAs include microRNAs,long ncRNAs,and circular RNAs.They are highly expressed in the brain and are involved in th... Non-coding RNAs(ncRNAs)are a class of functional RNAs that play critical roles in different diseases.NcRNAs include microRNAs,long ncRNAs,and circular RNAs.They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes of central nervous system(CNS)diseases.Mounting evidence indicates that ncRNAs play key roles in CNS diseases.Further elucidating the mechanisms of ncRNA underlying the process of regulating glial function that may lead to the identification of novel therapeutic targets for CNS diseases. 展开更多
关键词 Noncoding RNA MicroRNA Long noncoding RNA Circular RNA Astrocytes Microglia Oligodendrocytes
暂未订购 下载PDF
Upregulation of long noncoding RNA W42 promotes tumor development by binding with DBN1 in hepatocellular carcinoma 认领 引用 被引量：4
16
作者 Guang-Lin Lei Yan Niu +12 位作者 Si-Jie Cheng Yuan-Yuan Li Zhi-Fang Bai Ling-Xiang Yu Zhi-Xian Hong Hu Liu Hong-Hong Liu Jin Yan Yuan Gao Shao-Geng Zhang Zhu Chen Rui-Sheng Li Peng-Hui Yang 《World Journal of Gastroenterology》 SCIE CAS 2021年第20期2586-2602,共17页
BACKGROUND Hepatocellular carcinoma(HCC)is a malignancy found globally.Accumulating studies have shown that long noncoding RNAs(lncRNAs)play critical roles in HCC.However,the function of lncRNA in HCC remains poorly u... BACKGROUND Hepatocellular carcinoma(HCC)is a malignancy found globally.Accumulating studies have shown that long noncoding RNAs(lncRNAs)play critical roles in HCC.However,the function of lncRNA in HCC remains poorly understood.AIM To understand the effect of lncRNA W42 on HCC and dissect the underlying molecular mechanisms.METHODS We measured the expression of lncRNA W42 in HCC tissues and cells(Huh7 and SMMC-7721)by quantitative reverse transcriptase polymerase chain reaction.Receiver operating characteristic curves were used to assess the sensitivity and specificity of lncRNA W42 expression.HCC cells were transfected with pcDNA3.1-lncRNA W42 or shRNA-lncRNA W42.Cell functions were detected by cell counting Kit-8(CCK-8),colony formation,flow cytometry and Transwell assays.The interaction of lncRNA W42 and DBN1 was confirmed by RNA immunoprecipitation and RNA pull down assays.An HCC xenograft model was used to assess the role of lncRNA W42 on tumor growth in vivo.The Kaplan-Meier curve was used to evaluate the overall survival and recurrence-free survival after surgery in patients with HCC.RESULTS In this study,we identified a novel lncRNA(lncRNA W42),and investigated its biological functions and clinical significance in HCC.LncRNA W42 expression was upregulated in HCC tissues and cells.Overexpression of lncRNA W42 notably promoted the proliferative and invasion of HCC,and inhibited cell apoptosis.LncRNA W42 directly bound to DBN1 and activated the downstream pathway.LncRNA W42 knockdown suppressed HCC xenograft tumor growth in vivo.The clinical investigation revealed that HCC patients with high lncRNA W42 expression exhibited shorter survival times.CONCLUSION In vitro and in vivo results suggested that the novel lncRNA W42,which is upregulated in HCC,may serve as a potential candidate prognostic biomarker and therapeutic target in HCC patients. 展开更多
关键词 Hepatocellular carcinoma Long noncoding RNA Long noncoding RNA W42 Tumor DBN1 Cancer
暂未订购 下载PDF
Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer 认领 引用 被引量：19
17
作者 Mu-Lin Liu Qiao Zhang +4 位作者 Xiao Yuan Long Jin Li-Li Wang Tao-Tao Fang Wen-Bin Wang 《World Journal of Gastroenterology》 SCIE CAS 2018年第9期1004-1012,共9页
AIM To investigate the role of long noncoding RNA(lnc RNA) RP4 in colorectal cancer.METHODS Lentivirus-mediated lnc RNA RP4 overexpression and knockdown were performed in the colorectal cancer cell line SW480. Cell pr... AIM To investigate the role of long noncoding RNA(lnc RNA) RP4 in colorectal cancer.METHODS Lentivirus-mediated lnc RNA RP4 overexpression and knockdown were performed in the colorectal cancer cell line SW480. Cell proliferation, tumor growth, and early apoptosis were evaluated by a cell counting kit-8 assay, an in vivo xenograft tumor model, and annexin V/propidium iodide staining, respectively. Analysis of the lnc RNA RP4 mechanism involved assessment of the association of its expression with mi R-7-5 p and the SH3 GLB1 gene. Western blot analysis was also performed to assess the effect of lnc RNA RP4 on the autophagy-mediated cell death pathway and phosphatidylinositol-3-kinase(PI3 K)/Akt signaling.RESULTS Cell proliferation, tumor growth, and early apoptosis in SW480 cells were negatively regulated by lnc RNA RP4. Functional experiments indicated that lnc RNA RP4 directly upregulated SH3 GLB1 expression by acting as a competing endogenous RNA(ce RNA) for mi R-7-5 p. This interaction led to activation of the autophagy-mediated cell death pathway and de-repression of PI3 K and Akt phosphorylation in colorectal cancer cells in vivo.CONCLUSION Our results demonstrated that lnc RNA RP4 is a ce RNA that plays an important role in the pathogenesis of colorectal cancer, and could be a potential therapeutic target for colorectal cancer treatment. 展开更多
关键词 Colorectal cancer long noncoding RNA RP4 SH3GLB1 miR-7-5p competing endogenous RNA
暂未订购 下载PDF
Role of noncoding RNAs in liver fibrosis 认领 引用 被引量：11
18
作者 Qing-Yuan Li Tao Gong +5 位作者 Yi-Ke Huang Lan Kang Charlotte A Warner He Xie Li-Min Chen Xiao-Qiong Duan 《World Journal of Gastroenterology》 SCIE CAS 2023年第9期1446-1459,共14页
Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive alcohol.It is a dynamic and reversible process characterized by the activation of hepa... Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive alcohol.It is a dynamic and reversible process characterized by the activation of hepatic stellate cells and excess accumulation of extracellular matrix.Advanced fibrosis could lead to cirrhosis and even liver cancer,which has become a significant health burden worldwide.Many studies have revealed that noncoding RNAs(ncRNAs),including microRNAs,long noncoding RNAs and circular RNAs,are involved in the pathogenesis and development of liver fibrosis by regulating signaling pathways including transforming growth factor-βpathway,phosphatidylinositol 3-kinase/protein kinase B pathway,and Wnt/β-catenin pathway.NcRNAs in serum or exosomes have been reported to tentatively applied in the diagnosis and staging of liver fibrosis and combined with elastography to improve the accuracy of diagnosis.NcRNAs mimics,ncRNAs in mesenchymal stem cell-derived exosomes,and lipid nanoparticles-encapsulated ncRNAs have become promising therapeutic approaches for the treatment of liver fibrosis.In this review,we update the latest knowledge on ncRNAs in the pathogenesis and progression of liver fibrosis,and discuss the potentials and challenges to use these ncRNAs for diagnosis,staging and treatment of liver fibrosis.All these will help us to develop a comprehensive understanding of the role of ncRNAs in liver fibrosis. 展开更多
关键词 MicroRNAs Long noncoding RNAs Circular RNAs Liver fibrosis Diagnosis Treatment
暂未订购 下载PDF
Noncoding RNAs and pancreatic cancer 认领 引用 被引量：12
19
作者 juan-fei peng yan-yan zhuang +1 位作者 feng-ting huang shi-neng zhang 《World Journal of Gastroenterology》 SCIE CAS 2016年第2期801-814,共14页
Noncoding RNAs(nc RNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that nc RNAs play an important role in several physiological and pathological conditions such a... Noncoding RNAs(nc RNAs) represent a class of RNA molecules that typically do not code for proteins. Emerging data suggest that nc RNAs play an important role in several physiological and pathological conditions such as cancer. The best-characterized nc RNAs are the micro RNAs(mi RNAs), which are short, approximately 22-nucleotide sequences of RNA of approximately 22-nucleotide in length that regulate gene expression at the posttranscriptional level, through transcript degradation or translational repression. Mi RNAs can function as master gene regulators, impacting a variety of cellular pathways important to normal cellular functions as well as cancer development and progression. In addition to mi RNAs, long nc RNAs, which are transcripts longer than 200 nucleotides, have recently emerged as novel drivers of tumorigenesis. However, the molecular mechanisms of their regulation and function, and the significance of other nc RNAs such as piwi-interacting RNAs in pancreas carcinogenesis are largely unknown. This review summarizes the growing body of evidence supporting the vital roles of nc RNAs in pancreatic cancer, focusing on their dysregulation through both genetic and epigenetic mechanisms, and highlighting the promise of nc RNAs in diagnostic and therapeutic applications of pancreatic cancer. 展开更多
关键词 Noncoding RNAs Diagnosis Pancreaticcancer Therapy Prognosis
暂未订购 下载PDF
Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma 认领 引用 被引量：8
20
作者 Ting-Ting Yu Xi-Ming Xu +4 位作者 Yi Hu Jun-Jian Deng Wei Ge Na-Na Han Mei-Xia Zhang 《World Journal of Gastroenterology》 SCIE CAS 2015年第23期7208-7217,共10页
AIM: To study the expression of long noncoding RNAs(lncRNAs) in hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).METHODS: The lncRNA profiles between HBV-related HCC tissues and corresponding normal liver ... AIM: To study the expression of long noncoding RNAs(lncRNAs) in hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).METHODS: The lncRNA profiles between HBV-related HCC tissues and corresponding normal liver tissues were generated using microarray analysis. Datasets were analyzed using multiple algorithms to depict alterations in gene expression on the basis of gene ontology(GO), pathway analysis, and lncRNA levels.RESULTS: The microarray revealed that 1772 lncRNAs and 2508 mRNAs were differently expressed. The pathway analysis demonstrated that the cell cycle, cytokinecytokine receptor interaction, chemokine signaling pathway, and phosphoinositide 3-kinase-protein kinase B signaling pathway may play important roles in HCC.Several GO terms, such as cell cycle, DNA replication,immune response, and signal transduction, were enriched in gene lists, suggesting a potential correlation with HBVrelated HCC. The upregulated large intergenic noncoding RNA ULK4P2 was physically combined with enhancer of zeste homolog 2. Therefore, the lncRNAs may participate in regulating HBV-related HCC.CONCLUSION: lncRNAs play important roles in HCC,future studies should verify whether large intergenic noncoding ULK4P2 functions by combining with enhancer of zeste homolog 2 in HCC. 展开更多
关键词 enhancer of zeste homolog 2 Hepatocellularcarcinoma Long noncoding RNAs Microarray ULK4P2
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 14 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈