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Imported Cases of Monkeypox Virus CladeⅠa—China,2025 认领 引用
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作者 Danlei Liu Ye Lu +9 位作者 Chunli Hu Shiwei Yu Liming Xue Guannan Zhang Zaijiong Yi Mao Mao Shenwei Li Qiang Wang Zilong Zhang Zhengan Tian 《China CDC weekly》 SCIE CSCD 2026年第4期99-102,共4页
Introduction:Monkeypox virus(MPXV),an emerging zoonotic pathogen,comprises two main clades with distinct epidemiological and clinical characteristics.This study reports the epidemiological investigation and genomic ch... Introduction:Monkeypox virus(MPXV),an emerging zoonotic pathogen,comprises two main clades with distinct epidemiological and clinical characteristics.This study reports the epidemiological investigation and genomic characterization of imported MPXV cladeⅠa cases detected in China during 2025.Methods:During March and April 2025,two travelers arriving at Shanghai Pudong International Airport from the Democratic Republic of the Congo(DRC)underwent screening for MPXV infection.Clinical specimens were analyzed using real-time polymerase chain reaction(PCR),clade-specific PCR,and whole-genome sequencing to characterize the viral genomes.Results:Both cases tested positive for MPXV infection.Clade-specific PCR and whole-genome sequencing confirmed infection with MPXV cladeⅠa.The first case yielded partial viral genome data(approximately 7.2 kb;3.64%genome coverage),whereas the second case produced near-complete genome sequences(196.7 kb;>99%coverage)through combined second-and third-generation sequencing platforms.Phylogenetic analysis revealed that these sequences clustered closely with cladeⅠa strains currently circulating in the DRC.Conclusions:These findings demonstrate the effectiveness of port-based infectious disease surveillance and multi-agency joint prevention and control mechanisms in identifying and managing imported MPXV cases.Enhanced surveillance capacity,rapid laboratory confirmation,and robust multiagency collaboration are essential for preventing crossborder transmission of emerging infectious diseases. 展开更多
关键词 genomic characterization clade zoonotic pathogencomprises China epidemiological investigation monkeypox virus imported cases
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