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Systematic review of mitochondrial dysfunction and oxidative stress in aging:A focus on neuromuscular junctions 认领 引用
1
作者 Senlin Chai Ning Zhang +8 位作者 Can Cui Zhengyuan Bao Qianjin Wang Wujian Lin Ronald Man Yeung Wong Sheung Wai Law Rebecca Schönmehl Christoph Brochhausen Wing Hoi Cheung 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1947-1960,共14页
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pa... Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pathological factor contributing to the progression of sarcopenia.However,the morphological and functional changes in mitochondria and their interplay in the degeneration of the neuromuscular junction during aging remain poorly understood.A defined systematic search of the Pub Med,Web of Science and Embase databases(last accessed on October 30,2024)was conducted with search terms including'mitochondria','aging'and'NMJ'.Clinical and preclinical studies of mitochondrial dysfunction and neuromuscular junction degeneration during aging.Twentyseven studies were included in this systematic review.This systematic review provides a summary of morphological,functional and biological changes in neuromuscular junction,mitochondrial morphology,biosynthesis,respiratory chain function,and mitophagy during aging.We focus on the interactions and mechanisms underlying the relationship between mitochondria and neuromuscular junctions during aging.Aging is characterized by significant reductions in mitochondrial fusion/fission cycles,biosynthesis,and mitochondrial quality control,which may lead to neuromuscular junction dysfunction,denervation and poor physical performance.Motor nerve terminals that exhibit redox sensitivity are among the first to exhibit abnormalities,ultimately leading to an early decline in muscle strength through impaired neuromuscular junction transmission function.Parg coactivator 1 alpha is a crucial molecule that regulates mitochondrial biogenesis and modulates various pathways,including the mitochondrial respiratory chain,energy deficiency,oxidative stress,and inflammation.Mitochondrial dysfunction is correlated with neuromuscular junction denervation and acetylcholine receptor fragmentation,resulting in muscle atrophy and a decrease in strength during aging.Physical therapy,pharmacotherapy,and gene therapy can alleviate the structural degeneration and functional deterioration of neuromuscular junction by restoring mitochondrial function.Therefore,mitochondria are considered potential targets for preserving neuromuscular junction morphology and function during aging to treat sarcopenia. 展开更多
关键词 aging mitochondrial dysfunction neuromuscular junction oxidative stress sarcopenia systematic review
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Metal-organic frameworks for gas sensors:comprehensive review from principal,fabrication to application 认领 引用
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作者 Soon Hyeong So Seung Yong Lee +4 位作者 Hohyung Kang Hyegi Min Hee-Tae Jung Kyu Hyoung Lee Dae Woo Kim 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2026年第1期1-31,共31页
Gas sensors are valuable tools for human applications,and extensive research has been conducted in this field.However,practical implementation has yet to be fully realized.In response,efforts have been made to explore... Gas sensors are valuable tools for human applications,and extensive research has been conducted in this field.However,practical implementation has yet to be fully realized.In response,efforts have been made to explore metal-organic frameworks(MOFs),a novel class of porous materials,as potential solutions.MOFs exhibit exceptional porosity and highly tunable chemical compositions and structures,giving rise to a wide range of unique physical and chemical properties.Significant progress has been achieved in developing MOF-based gas sensors,improving sensing performance for various gases.This review aims to provide a comprehensive understanding of MOF-based gas sensors,even for readers unfamiliar with MOFs and gas sensors.It covers the working principles of these sensors,fundamental concepts of MOFs,strategies for tuning MOF properties,fabrication techniques for MOF films,and recent studies on MOF and MOF-derivative gas sensors.Finally,current challenges,overlooked aspects,and future directions for fully exploiting the potential of MOFs in gas sensor development are discussed. 展开更多
关键词 metal organic framework gas sensor gas transport fabrication review
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Current risk factors for male infertility and semen parameters:an umbrella review of systematic reviews and meta-analyses 认领 引用
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作者 Qi-Hao Wang Jian-Jun Ye +8 位作者 Ze-Yu Chen Chi-Chen Zhang Xin-Yang Liao Lei Zheng Kai Chen Xiang Tu Liang-Ren Liu Qiang Wei Yi-Ge Bao 《Asian Journal of Andrology》 SCIE CAS CSCD 2026年第3期284-296,共13页
Male infertility poses a substantial healthcare challenge and severely impacts the lives of patients.We aimed to investigate the risk factors for infertility and abnormal semen parameters.We conducted a comprehensive ... Male infertility poses a substantial healthcare challenge and severely impacts the lives of patients.We aimed to investigate the risk factors for infertility and abnormal semen parameters.We conducted a comprehensive search of the articles published in Web of Science,MEDLINE,and Embase databases from January 2000 to February 2025.Infertility,semen volume,sperm concentration,sperm count,sperm morphology,sperm motility,and sperm progressive motility were used as endpoints to evaluate the relevance of risk factors.A total of 43 studies were included,covering 67 risk factors associated with infertility and abnormal sperm parameters.A total of 249 effect sizes were scored individually using the Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)tool,of which 136(54.6%)were classified as“very low”,59(23.7%)as“low”,and 54(21.7%)as“moderate”.Suffering from type 1 diabetes,metabolic syndrome,hyperthyroidism,systemic lupus erythematosus,chronic prostatitis,and leukocytospermia may increase the risk of abnormal semen parameters.Poor lifestyle habits(obesity,sleep disorders,and smoking),exposure to pollutants and various compounds(carbon disulfide,organophosphates,and lead),the use of medications(sulfasalazine,mesalazine,and selective serotonin reuptake inhibitors),and even some viral infections(severe acute respiratory syndrome coronavirus 2,human papillomavirus,and hepatitis viruses)were associated with decreased semen quality.Regular physical exercise,nut consumption,and adherence to a healthy dietary pattern may reverse this process.An increasing number of factors are associated with infertility;however,some of the aforementioned studies lack verification of causal relationships.Future studies need to be well designed to further confirm these relationships. 展开更多
关键词 male infertility risk factors semen parameter umbrella review
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The roles of traditional Chinese medicine within an interdisciplinary team in predominantly Western medical settings:A scoping review 认领 引用
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作者 Arkers Kwan Ching Wong Nuo Shi +1 位作者 Annie Ho Janice Yuen Shan Ho 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期65-80,共16页
Background:Traditional Chinese medicine(TCM)is increasingly recognized for its holistic approach and effectiveness.Integrated medicine,emphasizing collaboration between TCM and Western medicine(WM),is promoted globall... Background:Traditional Chinese medicine(TCM)is increasingly recognized for its holistic approach and effectiveness.Integrated medicine,emphasizing collaboration between TCM and Western medicine(WM),is promoted globally to enhance healthcare delivery.However,the roles and responsibilities of TCM practitioners in predominantly Western medical settings are underexplored,potentially hindering their engagement in interprofessional collaboration.Objective:This scoping review investigated the roles and responsibilities of TCM practitioners and identified facilitators and barriers to TCM integration in Western medical contexts.Search strategy:We conducted a scoping review using data from eleven Chinese and English databases,including Cumulative Index of Nursing and Allied Health,MEDLINE,Pub Med,Embase,Web of Science,Cochrane Library,Psyc INFO,China National Knowledge Infrastructure.Wanfang,Chinese Scientific Journal Database,and the Chinese Science Citation Database.Inclusion criteria:Eligibility was limited to studies on TCM practitioners in interdisciplinary teams with Western professionals,published in Chinese or English,while excluding articles that lacked documentation of TCM involvement,or focused exclusively on TCM practices.Data extraction and analysis:Thematic analysis following Braun and Clarke's six-step framework was used to summarize data on the roles of TCM and TCM practitioners,and factors that facilitate and hinder the integration of TCM and WM.Results:Our systematic search yielded 31 relevant papers.We identified eight key roles of TCM practitioners:mitigating WM-induced side effects,facilitating WM tapering and prevention,attenuating disease progression,improving mental health,providing pain relief,supporting stroke rehabilitation,managing symptoms,and regulating the immune system.TCM practitioners fulfill these roles through accurate diagnosis,prescription,and collaborative care while also serving as educators.Five facilitators for TCM integration were identified:safety,recognition,policy support,accessibility,and treatment guidelines.Barriers included:safety concerns,lack of research,insufficient TCM knowledge among WM practitioners,attitudinal barriers,limited access,and inconvenience.Conclusion:Our review highlights the potential of TCM to enrich interdisciplinary teams in Western medical settings.Although there are successful integration models,significant barriers persist,including cost disparities and insufficient research.To achieve seamless integration,a multi-faceted approach that includes research collaboration,equitable policies,enhanced interprofessional education,and efforts to shift societal perceptions is essential. 展开更多
关键词 Chinese medicine Integrative medicine Scoping review Western medicine
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Acupuncture and moxibustion for chronic eczema:A systematic review 认领 引用
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作者 Yi-xi ZHAO Can ZHANG +1 位作者 Yan-yan ZHAO Sheng CHEN 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第2期149-168,共20页
Objective To systemically evaluate the effectiveness and safety of acupuncture and moxibustion for chronic eczema,and to provide evidence for acupuncture and moxibustion in the treatment of chronic eczema.Methods Rand... Objective To systemically evaluate the effectiveness and safety of acupuncture and moxibustion for chronic eczema,and to provide evidence for acupuncture and moxibustion in the treatment of chronic eczema.Methods Randomized controlled trials(RCTs)were retrieved from PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),VIP database,Wanfang database and China Biology Medicine disc(CBM),from the inception of the database to April 23,2025.The control group were sham acupuncture and moxibustion,no treatment,or conventional western medication.The intervention group were acupuncture and moxibustion therapy or acupuncture and moxibustion on the basis of the interventions as the control group.Meta-analysis was performed by using RevMan5.4.0 software according to Cochrane systematic evaluation method.Results Ultimately,53 RCTs were included.The results of the meta-analysis showed that compared with sham acupuncture and moxibustion,no treatment,or conventional western medication,acupuncture and moxibustion treatment for eczema area and severity index(EASI)score(mean difference[MD]=−2.23,95%confidence interval[CI]−2.61 to−1.85;P<0.00001),visual analogue scale(VAS)score(standardized mean difference[SMD]=−1.45,95%CI−2.04 to−0.87;P<0.00001),dermatology life quality index(DLQI)score(MD=−2.36,95%CI−3.25 to−1.48;P<0.00001),immunoglobulin E(IgE)(SMD=−1.26,95%CI−2.46 to−0.05;P=0.04),the overall response rate(odds ratio[OR]=4.58,95%CI 3.84 to 5.46;P<0.00001)and the recurrence rate(OR=0.14,95%CI 0.09 to 0.21;P<0.00001)were all better than those in the control group,and there were no severe adverse events reported.Conclusion Acupuncture and moxibustion can reduce the lesion area and severity of the patients with chronic eczema,effectively alleviate pruritus,improve the quality of life and decrease serum IgE.This therapy owns high overall response rate with low recurrence rate,and without severe adverse events,which is associated with a favorable long-term prognosis. 展开更多
关键词 Acupuncture Moxibustion Chronic eczema Therapeutic effect Systematic review Meta-analysis
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Abortion prevalence and its related factors in Iran:A systematic review and meta-analysis 认领 引用
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作者 Roghaye Ahangari Abolfazl Mohammadbeigi +1 位作者 Azadeh Asgarian Seyedeh Sakineh Latifi-Rostami 《Asian pacific Journal of Reproduction》 CAS 2026年第3期124-131,共8页
Objective:To estimate the pooled prevalence rate of different types of abortion and the most important related factors of abortion in Iran based on a systematic review and meta-analysis.Methods:This systematic review ... Objective:To estimate the pooled prevalence rate of different types of abortion and the most important related factors of abortion in Iran based on a systematic review and meta-analysis.Methods:This systematic review and meta-analysis was conducted on the Iranian studies during the February 1,2012 to December 31,2024.Abortion prevalence and its influencing factors were evaluated.Relevant keywords were used to find eligible studies in Web of Science,PubMed,Google Scholar,Scopus,Science-Direct and SID databases.Due to high heterogeneity in included studies,random-effects model was utilized to estimate the pooled estimated of abortion and its subgroups.Results:Out of 231 reviewed articles,only 11 articles on 24429 women were finally included.The pooled prevalence of induced abortion,spontaneous abortion,legal abortion and overall abortion was estimated as 7.65%(95%CI 4.24 to 11.95),5.92%(95%CI 0.24 to 18.32),1.66%(95%CI 0.83 to 2.76)and 7.23%(95%CI 1.07 to 18.22),respectively.Conclusions:Abortion is a worldwide major public health problem even in Iran and related to different socioeconomic and psychosocial factors.Its prevalence in Iran is high and it remains as reproductive health concern in Iran due to low fertility rate and oncoming up down population growth. 展开更多
关键词 Abortion Miscarriage Risk factors Prevalence Iran Systematic review
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Exploring cascading failures in supply chain risk management:A systematic review,2013-2024 认领 引用
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作者 Xiaoxin Zhu Jiahui Zhu +1 位作者 David Regan Zhimin Wen 《Journal of Safety Science and Resilience》 EI CSCD 2026年第2期301-317,共17页
Supply chain risk management has become increasingly crucial due to the complexity and interconnectivity of modern supply chains.Among various risk factors,cascading failures have emerged as a significant concern for ... Supply chain risk management has become increasingly crucial due to the complexity and interconnectivity of modern supply chains.Among various risk factors,cascading failures have emerged as a significant concern for risk management.This study systematically reviews the literature published between 2013 and 2024,focusing on cascading failures in supply chain networks.A total of 92 articles were selected from the Web of Science(WoS)database for in-depth analysis.The findings indicate that future research needs to achieve breakthroughs in three dimensions:data acquisition,theoretical innovation,and practical application.Specifically,integrating multi-source data is crucial for enhancing the accuracy,comprehensiveness,and timeliness of data in supply chain networks.Higher-order network modeling and digital twin technology will aid in more accurately simulating and predicting cascading failures.From a theoretical standpoint,exploring hybrid failure mechanisms and multi-level propagation patterns will deepen the understanding of failure propagation in complex networks.From a practical perspective,developing resilience design standards,intelligent early warning systems,and differentiated policy tools will strengthen the risk resistance capabilities of supply chains.Overcoming these challenges will require a holistic approach that combines data-driven insights,theoretical advancements,and practical solutions to build a safer and more resilient global supply chain system. 展开更多
关键词 Supply chain network Cascading failure Risk management Literature review
Research progress and future prospect of blasting theory and technology for deep rock masses:A review primarily based on Chinese perspectives 认领 引用
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作者 Chenxi Ding Renshu Yang +1 位作者 Zongxian Zhang Zhe Sui 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第4期1013-1030,共18页
Shallow mineral resources are gradually depleting worldwide,therefore,deep mining is becoming increasingly prevalent within the mining industry.Drilling and blasting are the predominant excavation methods used in deep... Shallow mineral resources are gradually depleting worldwide,therefore,deep mining is becoming increasingly prevalent within the mining industry.Drilling and blasting are the predominant excavation methods used in deep environments.However,challenges such as inefficient borehole utilization and significant over-or under-excavation are frequently encountered.Scientific investigations on deep rock mass blasting are crucial for the effective development and utilization of deep resources,underpinning safe and efficient deep mine operations.This paper identifies the challenges faced in deep rock mass blasting and presents a review of the current research,primarily from the perspective of Chinese institutions and their experiences,integrating theoretical and technical perspectives through a bibliometric analysis.First,key developmental trends and prominent research teams were identified in the context of this review.Subsequently,three principal areas of theoretical research are analyzed and summarized:blasting stress field evolution,crack propagation behavior,and vibrational response characteristics under in-situ stress conditions.The application and optimization of cut and perimeter blasting techniques for deep rock masses were also examined.Finally,drawing upon existing research,this study explores three key future directions:prediction of blasting effects,utilization of unloading stress waves for cooperative rock fragmentation,and optimization of production blasting in deep metal mines.This review aims to provide a systematic framework for future research in the field of deep rock mass blasting. 展开更多
关键词 deep rock mass blasting in-situ stress blasting characteristic systematic review
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Association between periodontal disease and prostatic disease:a systematic review and meta-analysis of observational studies 认领 引用
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作者 Qiang Li Lan Wu +5 位作者 Yi Zhang Di Huang Song Ou-Yang Jia-Yu Yang Bing-Hui Li Xian-Tao Zeng 《The Canadian Journal of Urology》 SCIE 2026年第1期7-20,共14页
Objective:Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases,which prompted us to explore the potential association.T... Objective:Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases,which prompted us to explore the potential association.To evaluate whether periodontal disease is associated with an increased risk of prostatic disease,including prostate cancer,benign prostatic hyperplasia(BPH),and prostatitis.Methods:A systematic search of observational studies concerning the relationship between periodontal disease and prostatic disease was performed in online databases PubMed,Embase,Web of Science,Scopus,CENTRAL,CNKI,and WanFang.Searches were conducted from database inception to 31 July 2025.Pooled hazard ratio(HR)or odds ratio(OR)with 95%confidence intervals(CIs)were synthesized.Subgroup analysis was used to detect the origin of heterogeneity,sensitivity analysis was employed to evaluate the robustness of the results,and publication bias analyses were also performed.R software was used to perform statistical analyses.Results:Sixteen studies that met the preset criteria were included in this study.In the pooled analysis,periodontal disease was associated with increased risk of prostate cancer(HR=1.23,95%CI:1.16-1.29,p<0.001)or BPH(OR=1.55,95%CI:1.41-1.70,p<0.001).Sensitivity analysis confirmed the robustness of the results.No obvious publication biaswas found in the meta-analysis.Only one cohort study reported that chronic periodontitis increases the risk of prostatitis(HR=2.521,95%CI:1.685-4.005,p<0.001).The effect of periodontal treatment on prostatic disease is still unclear.Conclusions:The systematic review and meta-analysis identified an observational association between periodontal disease and increased risks of prostate cancer and BPH.Because all included studies were observational,these results indicate association rather than causation,and further prospective and mechanistic studies are required to clarify temporality and causality. 展开更多
关键词 Periodontal diseases prostatic diseases prostatic neoplasms prostatic hyperplasia systematic review meta-analysis
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Correction: Optimizing Exciton and Charge-Carrier Behavior in Thick-Film Organic Photovoltaics: A Comprehensive Review 认领 引用
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作者 Lu Wei Yaxin Yang +2 位作者 Lingling Zhan Shouchun Yin Hongzheng Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第1期608-608,共1页
Correction to:Nano-Micro Letters(2026)18:10.http://gffzzd3cc09b8251d45dfsn5qpxbk9u05o6nou.ffgz.tsg.suse.edu.cn/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.Th... Correction to:Nano-Micro Letters(2026)18:10.http://gffzzd3cc09b8251d45dfsn5qpxbk9u05o6nou.ffgz.tsg.suse.edu.cn/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.The published version showed“Hongzhen Chen”,whereas the correct spelling should be“Hongzheng Chen”.The correct author name has been provided in this Correction,and the original article[1]has been corrected. 展开更多
关键词 charge carrier behavior exciton behavior comprehensive review thick film organic photovoltaics nano micro letters
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Adrenal metastasis of hepatocellular carcinoma after liver transplantation:Case report and systematic review of literature 认领 引用
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作者 José Manuel Ramia Mariano Franco +6 位作者 Cándido Alcázar Silvia Carbonell-Morote Juan Jesús Rubio-García María Rodríguez Sonia Pascual Paola Melgar Celia Villodre Tudela 《World Journal of Transplantation》 2026年第2期314-321,共8页
BACKGROUND Adrenal metastasis of hepatocellular carcinoma(AM-HCC)after liver transplantation(LT)is an infrequent entity,especially when it is the only site of recurrence.We present patients with these characteristics ... BACKGROUND Adrenal metastasis of hepatocellular carcinoma(AM-HCC)after liver transplantation(LT)is an infrequent entity,especially when it is the only site of recurrence.We present patients with these characteristics and systematically review previously published cases.No systematic review adhering to PRISMA criteria has been previously performed.AIM To systematic review of isolated AM-HCC after LT.METHODS Adhering to PRISMA guidelines,we performed unrestricted search for AM-HCC after LT in several databases,with no language restriction,updated through December 31,2024.RESULTS We obtained 38 articles.Only 14 articles,comprising 20 patients,were evaluated,to which we added our own case.Fourteen were single-case reports,and one was a series of seven retrospective cases.The median age was 56.1 years[interquartile range(IQR):23-72].The gender distribution was predominantly male(84.6%).The indications for LT were hepatocellular carcinoma(HCC)plus hepatitis B virus cirrhosis(11),hepatitis C virus(6),alcohol(3),and cryptogenic cirrhosis(1).The median HCC tumor size was 4.6 cm(IQR:3.8-13).One third of patients did not meet the Milan criteria.The median time between LT and the appearance of adrenal metastasis(AM)was 39.9 months(IQR:18-42.6).The AM was located on the left(11)and right side(10).Nineteen patients were treated with adrenalectomy,and two were treated with radiotherapy.After a median follow-up of 30 months,25%of patients were alive without recurrence.The median survival time was 29 months(IQR:24-38).CONCLUSION In the case of AM-HCC after LT,occurring as the solitary site of extrahepatic metastasis,adrenalectomy could be a therapeutic option for surgical candidates.It is safe,appears to increase survival,and reduces recurrence in selected patients. 展开更多
关键词 Adrenal Metastasis Hepatocellular carcinoma Liver transplantation Review
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Investigating the Mental Health of Left-Behind Children in China’s Rural Areas:A Systematic Review Approach 认领 引用
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作者 Jian Li Yide Chen +1 位作者 Xinyi Zhao Eryong Xue 《International Journal of Mental Health Promotion》 2026年第3期1-25,共25页
Background:The mobility of people in rural areas may lead to more and more left-behind children(LBC)appearing,and being an LBC brings a lot of risks to mental health,which could greatly hinder children’s development ... Background:The mobility of people in rural areas may lead to more and more left-behind children(LBC)appearing,and being an LBC brings a lot of risks to mental health,which could greatly hinder children’s development and undermine their happiness and safety in life.Previous scholars have conducted plenty of studies that focused on Chinese rural LBCs’mental health issues,such as what they exactly look like and some potential factors,but there remains a paucity of reviews about the relationship among certain mental health issues.We will try to figure out how the most common mental health issues of LBC in China’s rural areas correlate with each other,as well as their related factors.Methods:In this study,we used a systematic review approach to analyze 35 publications from Web of Science and EBSCO(to August 2025),followed by the sorting standards of Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2020.Results:By mainly using quantitative techniques,we found that Chinese rural LBC are more likely to have mental health issues than children who have no experience of being left behind,and they often suffer from depression,social anxiety,internet addiction,and suicidal ideation.These four mental health issues share influencing factors and positively correlate with each other.We also found that Chinese rural LBCs are somewhat resilient towards the risk factors of mental health issues,and national or social policies and interventions can really help them a lot.Conclusion:For Chinese rural LBC,there are important relationships among the common psychological disorders they often suffer,along with multiple factors that affect their mental health,which can help related scholars and practitioners pay attention to such mechanisms and think more comprehensively when they try to help the children who are left behind. 展开更多
关键词 Left-behind children rural area China mental health systematic review
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Outlier management in data analysis:a checklist for authors and reviewers 认领 引用
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作者 Evgenios Agathokleous Tao Xu Lei Yu 《Journal of Forestry Research》 SCIE EI CAS CSCD 2026年第3期1-6,共6页
The improper handling of outliers in the analysis of variance(ANOVA)presents a persistent challenge in forestry research,which may lead to biased results,inflated Type I error rates,and obscured scientific signals.The... The improper handling of outliers in the analysis of variance(ANOVA)presents a persistent challenge in forestry research,which may lead to biased results,inflated Type I error rates,and obscured scientific signals.The current practice is often an ad hoc method,potentially driven by a need to achieve statistical significance rather than principled scientific reasoning.This Editorial paper addresses this systemic issue by proposing a structured,step-by-step framework for the diagnosis and management of outliers.The framework guides researchers to first investigate the cause of an outlier(data error,measurement error,or genuine extreme value),then statistically assess its impact on ANOVA results and assumptions,and finally,make a transparent decision on its treatment.We strongly advise against the statistically problematic practice of replacing outliers with the mean of other replicates,as it violates data integrity and obscures true variability.Instead,we recommend robust alternatives,including data transformation,non-parametric tests,or the use of trimmed means.This approach aims to uphold statistical robustness and scientific integrity,thereby improving the rigor of forestry research and its publications. 展开更多
关键词 Journal editor Peer review Statistical analysis Science communication Scientific writing
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A Review of Robotic vNOTES Surgery:Current Applications,Advantages,and Future Directions 认领 引用
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作者 Lovell Daniel Y. YANG Qiannan GUAN Xiaoming 《四川大学学报（医学版）》 CAS CSCD 北大核心 2026年第3期633-644,共12页
Over the past 500 years,the convergence of three distinct paths–vaginal surgery,laparoscopy,and robotic technologies–has enabled the development of robot-assisted vaginal natural orifice transluminal endoscopic surg... Over the past 500 years,the convergence of three distinct paths–vaginal surgery,laparoscopy,and robotic technologies–has enabled the development of robot-assisted vaginal natural orifice transluminal endoscopic surgery(RA-vNOTES).The ongoing evolution of vaginal surgery has led to contemporary procedures such as hysterectomy,myomectomy,sacrocolpopexy,adnexal interventions,and oncologic operations,applicable to a wide range of diagnoses and pathologies.This approach offers patients significant benefits,including superior cosmetic outcomes,less pain,lower infection rates,and faster recovery of baseline quality of life.Surgeons benefit from improved ergonomics,better visualization,the ability to use multiple instruments,and enhanced tremor control.Robotic assistance has greatly expanded the ability to safely perform more complex cases,such as excision of stage 4 endometriosis with complete posterior cul-de-sac obliteration,as well as other procedures previously considered contraindicated in traditional vaginal surgery.Here,we present current findings and advances in RA-vNOTES and consider future developments in robotic surgery aimed at further improving minimally invasive techniques. 展开更多
关键词 Robotic surgery vNOTES Gynecology Minimally invasive surgery Surgical innovation Review
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Chinese herbal medicine for colorectal cancer:An overview of systematic reviews and evidence map 认领 引用
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作者 He-Ping Wang Xiao-Yan Qin +4 位作者 Bo-Wen Xu Tai-Cheng Lu Rui-Ke Gao Ming Lin Jie Li 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第7期346-361,共16页
BACKGROUND Colorectal cancer(CRC)accounts for second place of new cases in China.Chinese herbal medicine(CHM)is widely used as an integrative treatment for CRC.However,evidence on the efficacy of CHM for CRC remains u... BACKGROUND Colorectal cancer(CRC)accounts for second place of new cases in China.Chinese herbal medicine(CHM)is widely used as an integrative treatment for CRC.However,evidence on the efficacy of CHM for CRC remains unclear.AIM To evaluate quality of previous systematic reviews(SRs)and summarise evidence on CHM treatment for CRC.METHODS All available online academic databases were systematically searched from the time of their foundation to October 2025,and eligible systematic reviews investigating therapeutic effectiveness and safety of CHM in the treatment of CRC patients were incorporated into this study.Their reporting,methodological and evidence quality were evaluated using the PRISMA,AMSTAR-2,and GRADE.RESULTS Ninety-seven SRs were included in this study.Thirty of the included SRs were assessed as high in reporting quality,67 as moderate;12 SRs were assessed as moderate in methodological quality,27 as low quality,58 as critically low quality.Seven pieces of evidence assessed as moderate quality by GRADE approach,40 as low quality,and 46 as very low quality.Moderate-quality evidence showed that orally administered CHM plus XELOX increased the objective response rate(ORR)by 44%.Compound Kushen Injection plus FOLFOX increased ORR by 26%and Karnofsky Performance Status(KPS)improvement rate by 24%.Aidi Injection plus FOLFOX4 chemotherapy increased ORR by 22%,disease control rate by 10%and KPS improvement rate by 30%.CONCLUSION Orally administered CHM and CHM injections combined with chemotherapy have promising effects on tumor response and performance status of patients with advanced CRC. 展开更多
关键词 Chinese herbal medicine Colorectal cancer Randomized controlled trial Evidence map Overview of reviews Meta-analysis
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Improving peer review capacity and integrity in forestry journals 认领 引用
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作者 Matthew B.Russell Aaron R.Weiskittel 《Forest Ecosystems》 SCIE CAS CSCD 2026年第3期645-653,共9页
The peer review process in forestry journals has remained largely unchanged despite significant shifts in the academic publishing landscape over the past decade.Using data from 156 forestry journals and detailed metri... The peer review process in forestry journals has remained largely unchanged despite significant shifts in the academic publishing landscape over the past decade.Using data from 156 forestry journals and detailed metrics from 10 selected journals,we examine trends in peer-review capacity,associate editor roles,and publishing volume from 2000 through 2024.Over this period,the number of forestry articles published annually has increased more than fourfold,while the pool of available reviewers has contracted,creating unsustainable pressure on the review system.Open-access publishing now accounts for 45%of forestry articles,up from 20%in 2000,with implications for review timelines and quality assurance.We evaluate the potential of artificial in-telligence(AI)tools to assist with peer review,while acknowledging associated risks to scientific integrity.Drawing on a comparison of reviews from human experts and large language models,we propose recommen-dations for experimenting with alternative review models,implementing version control,and integratingAI responsibly into the peer review process. 展开更多
关键词 Academic publishing Peer review models Artificial intelligence Forest science
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Factors associated with aseptic loosening after primary total hip arthroplasty:A systematic review and meta-analysis 认领 引用
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作者 Guo-Qing Li Ji Zhang Yong Huang 《World Journal of Orthopedics》 2026年第1期149-163,共15页
BACKGROUND Aseptic loosening remains the leading cause of revision in primary total hip arthroplasty(pTHA).However,the literature demonstrates significant variability regarding the relative contributions of different ... BACKGROUND Aseptic loosening remains the leading cause of revision in primary total hip arthroplasty(pTHA).However,the literature demonstrates significant variability regarding the relative contributions of different factors.AIM To investigate the key determinants of aseptic loosening,we performed a systematic review and meta-analysis.METHODS A comprehensive search of PubMed,Web of Science,EMBASE,and the Cochrane Library was conducted,encompassing studies from database inception to January 1,2025.Meta-analyses were performed to evaluate factors associated with aseptic loosening following pTHA.Inclusion and exclusion criteria were systematically applied at each stage to ensure methodological transparency and reproducibility.Study quality was assessed using standardized categories.Pooled odds ratio(OR)with corresponding 95%confidence interval were calculated with random-or fixed-effects models to generate reliability estimates,and study heterogeneity was visualized using forest plots.Ten factors,categorized into patient-,surgeon-,and device-related domains,were reviewed and meta-analyzed.Funnel plot analysis demonstrated a relatively symmetrical distribution,suggesting minimal publication bias.RESULTS A meta-analysis of 20 studies(520789 participants)found a pooled prevalence of 1.96%.Significant risk factors for aseptic loosening after pTHA included elevated body mass index(OR=1.116,P<0.001),higher Charlson comorbidity index(OR=1.378,P<0.001),prosthesis-related factors(OR=1.497,P<0.001),and adverse lifestyles(OR=2.198,P=0.037).Protective factors were non-white race(OR=0.445,P<0.001)and favorable genetics(OR=0.723,P<0.001).Male sex increased risk(OR=1.232,P=0.016),while age and anatomy were not significant.Surgical expertise showed a slight protective effect(OR=1.048,P<0.001).A comprehensive understanding of the modifiable and non-modifiable factors contributing to aseptic loosening after pTHA requires consideration of patient-related factors,surgical expertise,and prosthesis characteristics.CONCLUSION The identification of these factors is critical for risk mitigation.High-risk patients should receive targeted counseling regarding individualized profiles.Further studies are warranted to establish clearer causal relationships and identify additional contributing factors. 展开更多
关键词 Factors Aseptic loosening Primary total hip arthroplasty Systematic review Meta-analysis
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Artificial intelligence assisted 3D in the robotic urooncology?A systematic review and narrative synthesis of current applications,challenges and future directions 认领 引用
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作者 Bara Barakat Bilal Al-Absi +3 位作者 Boris Hadaschik Christian Rehme Samer Schakaki Joerg Bauer 《The Canadian Journal of Urology》 SCIE 2026年第1期105-116,共12页
Background:Artificial intelligence(AI)-assisted threedimensional(3D)surgical platforms,integrated with augmented reality,have the potential to improve intraoperative anatomical recognition and provide surgeons with an... Background:Artificial intelligence(AI)-assisted threedimensional(3D)surgical platforms,integrated with augmented reality,have the potential to improve intraoperative anatomical recognition and provide surgeons with an immersive,dynamic operating environment during urooncological procedures.This review aims to examine the current applications of AI in robotic uro-oncology,with a particular focus on its role in facilitating intraoperative navigation during complex surgeries.Methods:A systematic literature search was performed across PubMed,the National Library of Medicine,MEDLINE,the Cochrane Central Register of Controlled Trials(CENTRAL),ClinicalTrials.gov,and Google Scholar to identify relevant studies published up to July 2025.The search strategy incorporated a predefined set of keywords,including AI,machine learning,radical prostatectomy(RP),robotic-assisted radical prostatectomy(RARP),robotassisted partial nephrectomy(RAPN),and robot-assisted radical cystectomy(RARC).Only clinical trials,full-text peer-reviewed publications,and original research articles were included.Studies were eligible for inclusion if they evaluated or described applications of AI in RARP,RAPN,or RARC.Results:Technological advancements have substantially transformed the field of uro-oncologic surgery.In particular,AI and AI-assisted intraoperative navigation in RARP demonstrate considerable potential to objectively assess surgical performance and predict clinical outcomes.In RAPN,the adoption of preoperative,interactive 3D virtualmodels for surgical planning has influenced surgical decisions,thus,enhanced precision in resection planning correlates with superior nephron-sparing outcomes and optimized selective clamping.AI applications in RARC,techniques such as augmented reality(AR)can overlay critical information on the surgical field,by facilitating navigation through complex anatomical planes and enhancing identification of critical structures.Conclusion:AI appears to enhance robotic uro-oncologic procedures by increasing operative precision and supporting individualised surgical treatment strategies. 展开更多
关键词 artificial intelligence robot-assisted surgery machine learning deep learning automatic three-dimensional surgical navigation intuitive surgical systematic review
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Correlation between non-alcoholic fatty liver disease and erectile dysfunction:A systematic narrative review 认领 引用
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作者 Yan-Fei He Ning Bian +6 位作者 Huan-Zhi Wang Xiao-Dong Hu Jun-Qiang Liu Shuang-Feng Lu Ni Wu Qin-Tong He Hu-Ming Li 《World Journal of Hepatology》 2026年第4期190-199,共10页
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,as well as a growing public health concern.Erectile dysfunction(ED)is one of the most common sexual dysfunctions in... BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,as well as a growing public health concern.Erectile dysfunction(ED)is one of the most common sexual dysfunctions in men.Currently,clinical research on the relationship between NAFLD and ED is limited.AIM To systematically review and narrative synthesize the existing evidence on the association between NAFLD and ED,and to elucidate potential underlying mechanisms.METHODS We conducted a comprehensive search of various electronic databases to identify original observational studies investigating the association between NAFLD and ED.However,due to significant heterogeneity among the included studies and the limited number of eligible investigations,we opted for a narrative synthesis instead of a meta-analysis.RESULTS A total of seven observational studies,involving 4442 participants(2043 of whom had NAFLD),were included in the analysis.The evidence consistently indicates a significant positive association between NAFLD and ED.Key influencing factors identified across the studies included age,components of metabolic syndrome,insulin resistance,serum testosterone levels,and psychological factors such as anxiety.CONCLUSION Existing evidence indicates a strong correlation between NAFLD and ED.The strength of this association is influenced by various factors,including age,insulin resistance,testosterone levels,and anxiety.NAFLD is an important risk factor for ED.Further high-quality studies are needed to confirm this relationship and explain its underlying mechanisms. 展开更多
关键词 Non-alcoholic fatty liver disease Erectile dysfunction Chronic liver diseases Sexual dysfunction Metabolic syndrome Insulin resistance Systematic review Narrative synthesis
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Pulmonary sclerosing pneumocytoma with lymph node metastasis and high 18FDG uptake in PET/CT:a rare case report and literature review 认领 引用
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作者 Jingfeng XU Yilei ZHAO +1 位作者 Qiuli WU Feng CHEN 《Journal of Zhejiang University-SCIENCE B》 SCIE CAS CSCD 2026年第2期202-206,共5页
Pulmonary sclerosing pneumocytoma(PSP)was first reported by Liebow and Hubbell(1956).It was initially called pulmonary sclerosing hemangioma(PSH)because it was thought to be derived from endothelial cells with rich va... Pulmonary sclerosing pneumocytoma(PSP)was first reported by Liebow and Hubbell(1956).It was initially called pulmonary sclerosing hemangioma(PSH)because it was thought to be derived from endothelial cells with rich vascularity.However,the 2015 World Health Organization Classification of Lung Tumors removed the term"sclerosing hemangioma,1 since these tumors lack vascular origin(Travis et al.2015),and the renamed tumor was considered a rare and benign lung tumor.However,several reports have described PSP with lymph node metastasis(Soo et al.,2017).Thus,PSP is not always benign and has the potential to metastasize. 展开更多
关键词 literature review endothelial cells pulmonary sclerosing pneumocytoma psp lymph node metastasis pulmonary sclerosing pneumocytoma pulmonary sclerosing hemangioma psh F DG uptake PET CT
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