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Value of inflammatory markers in predicting psychotic complications of postoperative depression after cerebrovascular intervention 认领 引用
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作者 Feng Yang Ru-Juan Zhou +3 位作者 Wu Xu Yan Li Dong-Heng Luan Ming-Yang Xu 《World Journal of Psychiatry》 SCIE 2026年第6期219-228,共10页
BACKGROUND Post-intervention depression with psychotic features represents a severe complication in cerebrovascular intervention that substantially impedes recovery and quality of life.Growing evidence implicates neur... BACKGROUND Post-intervention depression with psychotic features represents a severe complication in cerebrovascular intervention that substantially impedes recovery and quality of life.Growing evidence implicates neuroinflammation as a key pathophysiological mechanism linking procedural stress,ischemia-reperfusion injury,and the development of post-procedural neuropsychiatric sequelae.Identifying reliable biomarkers for early risk stratification is crucial for preemptive management.AIM To investigate the value of human chitinase-3-like protein 1(YKL-40/CHI3L1),high-sensitivity C-reactive protein,and interleukin-6 in predicting psychotic complications of postoperative depression following cerebrovascular intervention.METHODS General patient data from 94 patients who underwent cerebrovascular intervention and serum levels of YKL-40,high-sensitivity C-reactive protein,and interleukin-6 measured preoperatively and on postoperative day 1,days 3,and days 7 were collected and compared between the two groups.Multivariate logistic regression identified independent risk factors for psychotic complications.Receiver operating characteristic curve analysis evaluated the predictive efficacy of each inflammatory marker,and the correlation between inflammatory marker levels and psychiatric assessment scale scores was analyzed.RESULTS Univariate and multivariate logistic regression analyses identified YKL-40 levels on postoperative day 3,National Institute of Health Stroke Scale scores on postoperative day 7,and intraoperative complications as independent risk factors for postoperative depressive disorder with psychotic complications(P<0.05).Receiver operating characteristic curve analysis indicated that the inflammatory markers measured on postoperative day 3 had the highest predictive value.Among them,YKL-40 had the largest area under the curve of 0.892(95%confidence interval:0.821-0.963),with an optimal cut-off value of 156.4 ng/mL,yielding a sensitivity of 85.7%and a specificity of 84.8%.Spearman correlation analysis revealed that YKL-40 levels on postoperative day 3 in the complication group were significantly positively correlated with both Hamilton Depression Rating Scale-17 scores(r=0.612,P<0.001)and Positive and Negative Syndrome Scale positive subscale scores(r=0.584,P<0.001).CONCLUSION YKL-40 demonstrated good predictive efficacy for psychotic complications of depression following cerebrovascular intervention.Dynamic monitoring of YKL-40 can facilitate early identification of high-risk patients and enable timely,effective interventions. 展开更多
关键词 Inflammatory markers Cerebrovascular intervention Postoperative depression Psychotic complications Predictive value
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The Predictive Value of SPP1 Gene Expression for the Survival of Advanced Liver Cancer Treated with Transarterial Chemoembolization 认领 引用
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作者 Yu Cai Pu Yan +3 位作者 Chang Tian Yuqing Li Yuanyuan Jia Siqi Wang 《Proceedings of Anticancer Research》 2025年第1期97-107,共11页
Objective:To evaluate the predictive value of secreted phosphoprotein 1(SPP1)gene expression for postoperative survival in patients with advanced liver cancer undergoing hepatic artery interventional chemoembolization... Objective:To evaluate the predictive value of secreted phosphoprotein 1(SPP1)gene expression for postoperative survival in patients with advanced liver cancer undergoing hepatic artery interventional chemoembolization treatment.Method:Bioinformatics methods,including gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis,were used to identify genes related to survival prognosis in hepatocellular carcinoma(HCC)patients.A retrospective analysis of 115 advanced liver cancer patients treated between January 2016 and October 2017 was conducted.Patients were categorized into SPP1 high-expression(n=89)and low-expression groups(n=26).Additionally,115 healthy individuals served as the control group.The relationship between SPP1 expression and clinical pathological features was analyzed.A 60-month follow-up and logistic regression analysis identified risk factors affecting survival.Results:SPP1 mRNA expression was significantly higher in liver cancer patients compared to healthy controls(P<0.05).SPP1 expression levels were significantly associated with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging(P<0.05).High SPP1 expression,along with tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,were independent risk factors for survival(P<0.05).The 60-month survival rate was 17.39%,with a median survival of 40 months in the low-expression group versus 18 months in the high-expression group(P<0.05).Conclusion:SPP1 expression is significantly upregulated in advanced liver cancer patients and has predictive value for postoperative survival following hepatic artery chemoembolization treatment.SPP1,combined with clinical indicators such as tumor size,Child-Pugh grading,lymph node metastasis,and BCLC staging,may serve as a prognostic biomarker for interventional treatment outcomes. 展开更多
关键词 SPP1 Transarterial chemoembolization Advanced liver cancer Survival period Predictive value
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Predictive value of C-reactive protein,procalcitonin,and total bilirubin levels for pancreatic fistula after gastrectomy for gastric cancer 认领 引用 被引量：3
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作者 Jing-Long Yuan Xuan Wen +1 位作者 Pan Xiong Li Pei 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第2期183-190,共8页
BACKGROUND Gastric cancer is the most common malignancy of the digestive system and surgical resection is the primary treatment.Advances in surgical technology have reduced the risk of complications after radical gast... BACKGROUND Gastric cancer is the most common malignancy of the digestive system and surgical resection is the primary treatment.Advances in surgical technology have reduced the risk of complications after radical gastrectomy;however,post-surgical pancreatic fistula remain a serious issue.These fistulas can lead to abdominal infections,anastomotic leakage,increased costs,and pain;thus,early diagnosis and prevention are crucial for a better prognosis.Currently,C-reactive protein(CRP),procalcitonin(PCT),and total bilirubin(TBil)levels are used to predict post-operative infections and anastomotic leakage.However,their predictive value for pancreatic fistula after radical gastrectomy for gastric cancer remains unclear.The present study was conducted to determine their predictive value.AIM To determine the predictive value of CRP,PCT,and TBil levels for pancreatic fistula after gastric cancer surgery.METHODS In total,158 patients who underwent radical gastrectomy for gastric cancer at our hospital between January 2019 and January 2023 were included.The patients were assigned to a pancreatic fistula group or a non-pancreatic fistula group.Multivariate logistic analysis was conducted to assess the factors influencing development of a fistula.Receiver operating characteristic(ROC)curves were used to determine the predictive value of serum CRP,PCT,and TBil levels on day 1 postsurgery.RESULTS On day 1 post-surgery,the CRP,PCT,and TBil levels were significantly higher in the pancreatic fistula group than in the non-pancreatic fistula group(P<0.05).A higher fistula grade was associated with higher levels of the indices.Univariate analysis revealed significant differences in the presence of diabetes,hyperlipidemia,pancreatic injury,splenectomy,and the biomarker levels(P<0.05).Logistic multivariate analysis identified diabetes,hyperlipidemia,pancreatic injury,CRP level,and PCT level as independent risk factors.ROC curves yielded predictive values for CRP,PCT,and TBil levels,with the PCT level having the highest area under the curve(AUC)of 0.80[95%confidence interval(CI):0.72-0.90].Combined indicators improved the predictive value,with an AUC of 0.86(95%CI:0.78-0.93).CONCLUSION Elevated CRP,PCT,and TBil levels predict risk of pancreatic fistula post-gastrectomy for gastric cancer. 展开更多
关键词 Procalcitonin C-reactive protein Total bilirubin Radical gastrectomy for gastric cancer Pancreatic fistula Predictive value
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Clinical prediction of carcinoembryonic antigen combined with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for postoperative survival in colorectal cancer 认领 引用
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作者 Tao Wang Chang Liu Jun Jiang 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第4期126-134,共9页
BACKGROUND Colorectal cancer(CRC)presents a significant global health burden,with considerable variation in survival following curative surgery.Identifying patients at high risk of poor outcomes is crucial for tailore... BACKGROUND Colorectal cancer(CRC)presents a significant global health burden,with considerable variation in survival following curative surgery.Identifying patients at high risk of poor outcomes is crucial for tailored treatment and surveillance strategies.Evidence indicates that individual prognostic markers,whether tumor-associated or inflammation-based,offer limited predictive value.This study posits that a combined model integrating carcinoembryonic antigen(CEA),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)will provide a more accurate and robust prediction of postoperative survival in patients with CRC than any single biomarker alone.AIM To evaluate the prognostic value of combined CEA,NLR,and PLR in CRC.METHODS This study retrospectively enrolled 120 CRC patients who underwent radical resection from July 2021 to July 2022.Based on three-year survival status,patients were classified into a mortality group(43 patients)and a survival group(77 patients).Baseline NLR,PLR,and CEA levels were compared between groups.Cox proportional hazards regression and receiver operating characteristic curve analyses were used to identify survival risk factors and evaluate prognostic utility.RESULTS Among 120 patients,43 died within 3 years postoperatively,yielding a mortality rate of 35.83%.Comparing clinical data between groups,the deceased group displayed significantly higher serum levels of NLR,PLR,and CEA than the surviving group,along with a higher proportion of tumors>5 cm in diameter and distant metastases(P<0.05).Cox regression analysis demonstrated that elevated postoperative serum NLR,PLR,and CEA levels constitute risk factors for postoperative survival in CRC patients.Receiver operating characteristic curve analysis revealed that the area under the curve for predicting postoperative survival using NLR,PLR,and CEA individually were 0.896,0.805,and 0.880,correspondingly.The integrated area under the curve for the three biomarkers was 0.977,indicating significantly higher predictive value than any single marker(P<0.0001).CONCLUSION Combined assessment of inflammatory markers NLR,PLR and tumor marker CEA provides valuable prognostic information for CRC patient survival. 展开更多
关键词 Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Carcinoembryonic antigen Colorectal cancer Postoperative survival Predictive value
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The Predictive Value of Combined Synthetic MRI Features and PSAD for Clinically Significant Prostate Cancer 认领 引用 被引量：1
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作者 Yunqi Yang Yukang Hu Chunhua Xia 《Journal of Clinical and Nursing Research》 2025年第12期223-230,共8页
Objective:To investigate the diagnostic and predictive value of MRI features combined with clinical indicators for prostate cancer(PCa)and clinically significant prostate cancer(csPCa),and to establish a non-invasive ... Objective:To investigate the diagnostic and predictive value of MRI features combined with clinical indicators for prostate cancer(PCa)and clinically significant prostate cancer(csPCa),and to establish a non-invasive combined model.Methods:A total of 36 patients with pathologically confirmed benign lesions(44 foci)and 23 patients with PCa(49 foci),including 25 foci of csPCa and 68 foci of non-csPCa,were included.SyMRI quantitative maps and clinical indicators were collected,and 224 imaging features were extracted.The intra-and inter-group correlation coefficients(ICC)for each feature were calculated using intra-and inter-group correlation analysis,and features with an ICC>0.75 were selected as stable features that could be reproducibly extracted.Independent predictors were screened using logistic regression to construct single and combined models,and the performance was evaluated using ROC curves.Results:Age,PSAD,PD map contrast,and T2 map joint entropy were significantly higher in the PCa group compared to the benign group,while the median ADC was significantly lower(p<0.05).The above-mentioned indicators were significantly correlated with PCa and csPCa,and the diagnostic performance of the combined model was superior to that of a single MRI or clinical model.Conclusion:MRI features combined with PSAD can effectively differentiate PCa and predict csPCa,providing a non-invasive quantitative diagnostic basis for clinical practice. 展开更多
关键词 Prostate cancer Prostate-specific antigen Synthetic magnetic resonance imaging Predictive value
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Clinical value of predicting bleeding after endoscopic submucosal dissection for early esophageal cancer 认领 引用
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作者 Sheng-Nan Liu Zhuo Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第11期346-356,共11页
BACKGROUND The incidence of esophageal cancer is high,and its prognosis is poor.Endoscopic submucosal dissection(ESD)is an important,minimally invasive treatment for early esophageal cancer,but the risk of postoperati... BACKGROUND The incidence of esophageal cancer is high,and its prognosis is poor.Endoscopic submucosal dissection(ESD)is an important,minimally invasive treatment for early esophageal cancer,but the risk of postoperative bleeding affects its efficacy.AIM To explore risk factors of bleeding after ESD and evaluate the predictive value of a gradient boosting machine(GBM)model for postoperative bleeding.METHODS The clinical data of 178 early esophageal cancer patients who underwent ESD at the Affiliated Hospital of Xuzhou Medical University from October 2019 to October 2024 were analyzed retrospectively.Patients were divided into two groups(bleeding and non-bleeding).Univariate and multivariate logistic regression analyses identified risk factors for postoperative bleeding,leading to the construction of the GBM prediction model.The receiver operating characteristic(ROC)curve evaluated the predictive efficacy of the GBM model and bleeding after ESD trend from Japan(BEST-J)score.RESULTS Among 178 patients who received ESD treatment,29 cases(16.29%)had bleeding,and 149 cases(83.71%)had no bleeding.The average BEST-J score and the proportion of high-risk and extremely high-risk patients were higher in the bleeding group than in the non-bleeding group(P<0.05).Multivariate logistic regression analysis showed that tumor size≥3 cm,surgical bleeding,and Creactive protein(CRP)were independent risk factors for bleeding after ESD in patients with early esophageal cancer(P<0.05).The ROC curve showed that the area under the curve of the GBM prediction model based on the influencing factors was greater than that of the BEST-J score(0.818 vs 0.653,P<0.05).CONCLUSION The GBM prediction model based on tumor size≥3 cm,surgical bleeding,and high CRP levels is more effective than the BEST-J score at predicting bleeding after ESD. 展开更多
关键词 Clinical predictive value Early esophageal cancer Endoscopic submucosal dissection Influencing factors Minimal invasiveness Postoperative bleeding
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Serum inflammatory biomarkers can predict clinical outcomes in patients with sepsis-associated gastrointestinal dysfunction 认领 引用
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作者 You-Hui Liu Qing-Yang Chen +1 位作者 Fei-Yue Dai Xin-Yu Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第2期139-146,共8页
BACKGROUND Effective predictive indicators for clinical outcomes in septic patients with gastrointestinal dysfunction(GID)remain lacking.AIM To evaluate the relationship between serum inflammatory biomarkers(SIBs)and ... BACKGROUND Effective predictive indicators for clinical outcomes in septic patients with gastrointestinal dysfunction(GID)remain lacking.AIM To evaluate the relationship between serum inflammatory biomarkers(SIBs)and clinical outcomes in patients with sepsis-induced GID.METHODS A total of 117 sepsis-induced GID patients were selected(January 2021 to January 2025).They were grouped into poor[n=76;Acute Physiology and Chronic Health Evaluation II(APACHE II)score>10]and good(n=41;APACHE II≤10)prognosis groups based on outcomes.Clinical variables(sex,age,body mass index,smoking history,diabetes,hypertension,and infection site)were collected.SIBs,encompassing procalcitonin(PCT),C-reactive protein(CRP),interleukin(IL)-6/10,and tumor necrosis factor(TNF)-α,were analyzed.Correlation analyses were conducted to assess the associations of SIBs with Sequential Organ Failure Assessment(SOFA)and APACHE II scores.Receiver operating characteristic curves visualized SIBs’predictive performance,and multivariate analysis identified independent outcome predictors.RESULTS The groups were similar in age,sex,body mass index,comorbidities,and major infection site.The poor prognosis group exhibited elevated APACHE II,SOFA,PCT,CRP,IL-6,IL-10,and TNF-αthan the good prognosis cohort.SIBs correlated positively with both APACHE II and SOFA scores.When used to predict outcomes individually,SIBs yielded an area under the curve range of 0.660-0.780 in septic patients with GID,whereas combined biomarker analysis increased the area under the curve to 0.906.APACHE II,SOFA,PCT,CRP,IL-6,and TNF-αacted as independent predictors of prognosis.CONCLUSION SIBs correlate intimately with clinical outcomes in sepsis-induced GID patients. 展开更多
关键词 Serum inflammatory biomarkers Procalcitonin C-reactive protein Interleukin-6/10 Sepsis Gastrointestinal dysfunction Clinical outcome Predictive value
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Analysis of Preoperative Risk Factors and Serological Predictive Indicators for Complicated Appendicitis 认领 引用
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作者 FENG Lizong WANG Shunzheng +2 位作者 WANG Longhui LIANG Guogang ZHOU Yunpeng 《外文科技期刊数据库（文摘版）医药卫生》 2026年第5期040-045,共6页
Objective To analyze preoperative independent risk factors for complicated appendicitis (CA), and explore the predictive efficacy of serum C-reactive protein (CRP) and fibrinogen for CA, so as to optimize preoperative... Objective To analyze preoperative independent risk factors for complicated appendicitis (CA), and explore the predictive efficacy of serum C-reactive protein (CRP) and fibrinogen for CA, so as to optimize preoperative stratification and individualized treatment of acute appendicitis. Methods A retrospective analysis was performed on 362 pathologically diagnosed adult acute appendicitis patients hospitalized in Qingdao Eighth People's Hospital from 2022 to 2023, including 87 CA patients and 275 uncomplicated appendicitis (UA) patients grouped by postoperative pathology. Baseline demographics, clinical manifestations, serological parameters and abdominal CT features were compared. Univariate analysis, binary Logistic regression and ROC curve were applied to screen risk factors and verify diagnostic values. Results Age, gender and BMI were balanced between two groups (P>0.05). Fever, abdominal rebound tenderness, multiple inflammatory-coagulation indicators, serum albumin and appendiceal fecalith differed significantly between groups (allP<0.05). Elevated white blood cell count, CRP, fibrinogen and appendiceal fecalith were independent CA risk factors (all P<0.05). ROC results revealed CRP (AUC=0.790, cut-off=14.105 mg/L, sensitivity=81.6%, specificity=70.9%) and fibrinogen (AUC=0.832, cut-off=4.12 g/L, sensitivity=60.9%, specificity=86.5%) exerted favorable predictive performance, while fecalith and white blood cell count showed limited diagnostic value alone. Conclusion Appendiceal fecalith and elevated white blood cell count are independent CA risk factors. CRP and fibrinogen serve as reliable preoperative serological biomarkers for CA prediction. Combined assessment of the two indicators, peritoneal signs and CT fecalith findings facilitates early CA identification, improves therapeutic decision-making and reduces postoperative complications. 展开更多
关键词 acute appendicitis complicated appendicitis risk factors C-reactive protein fibrinogen predictive value
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Comparison of the predictive value of anthropometric indicators for the risk of benign prostatic hyperplasia in southern China 认领 引用 被引量：3
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作者 Meng-Jun Huang Yan-Yi Yang +6 位作者 Can Chen Rui-Xiang Luo Chu-Qi Wen Yang Li Ling-Peng Zeng Xiang-Yang Li Zhuo Yin 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第2期265-270,共6页
This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Ce... This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital,Central South University(Changsha,China)from June to December 2020 were enrolled in this study.The characteristic data were collected,including basic anthropometric indices,lipid parameters,six anthropometric indicators,prostate-specific antigen,and total prostate volume.The odds ratios(ORs)with 95%confidence intervals(95%CIs)for all anthropometric parameters and BPH were calculated using binary logistic regression.To assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values,receiver operating characteristic(ROC)curves and the related areas under the curves(AUCs)were utilized.All six indicators had diagnostic value for BPH(all P≤0.001).The visceral adiposity index(VAI;AUC:0.797,95%CI:0.759–0.834)had the highest AUC and therefore the highest diagnostic value.This was followed by the cardiometabolic index(CMI;AUC:0.792,95%CI:0.753–0.831),lipid accumulation product(LAP;AUC:0.766,95%CI:0.723–0.809),waist-to-hip ratio(WHR;AUC:0.660,95%CI:0.609–0.712),waist-to-height ratio(WHtR;AUC:0.639,95%CI:0.587–0.691),and body mass index(BMI;AUC:0.592,95%CI:0.540–0.643).The sensitivity of CMI was the highest(92.1%),and WHtR had the highest specificity of 94.1%.CMI consistently showed the highest OR in the binary logistic regression analysis.BMI,WHtR,WHR,VAI,CMI,and LAP all influence the occurrence of BPH in middle-aged and older men(all P≤0.001),and CMI is the best predictor of BPH. 展开更多
关键词 benign prostate hyperplasia obesity index predictive value risk prediction
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Predictive Value of Initial Serum Human Chorionic Gonadotropin Levels for Pregnancies after Single Fresh and Frozen Blastocyst Transfer 认领 引用 被引量：4
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作者 赵伟娥 李玉洁 +3 位作者 欧建平 孙鹏 陈文秋 梁晓燕 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2017年第3期395-400,共6页
As one of the earliest markers for predicting pregnancy outcomes, human chorionic gonadotropin(h CG) values have been inconclusive on reliability of the prediction after frozen and fresh embryo transfer(ET). In this r... As one of the earliest markers for predicting pregnancy outcomes, human chorionic gonadotropin(h CG) values have been inconclusive on reliability of the prediction after frozen and fresh embryo transfer(ET). In this retrospective study, patients with positive h CG(day 12 after transfer) were included to examine the h CG levels and their predictive value for pregnancy outcomes following 214 fresh and 1513 vitrified-warmed single-blastocyst transfer cycles. For patients who got clinical pregnancy, the mean initial h CG value was significantly higher after frozen cycles than fresh cycles, and the similar result was demonstrated for patients with live births(LB). The difference in h CG value existed even after adjusting for the potential covariates. The area under curves(AUC) and threshold values calculated by receiver operator characteristic curves were 0.944 and 213.05 m IU/m L for clinical pregnancy after fresh ET, 0.894 and 399.50 m IU/m L for clinical pregnancy after frozen ET, 0.812 and 222.86 m IU/m L for LB after fresh ET, and 0.808 and 410.80 m IU/mL for LB after frozen ET with acceptable sensitivity and specificity, respectively. In conclusion, single frozen blastocyst transfer leads to higher initial h CG values than single fresh blastocyst transfer, and the initial h CG level is a reliable predictive factor for predicting IVF outcomes. 展开更多
关键词 human chorionic gonadotropin single blastocyst transfer frozen embryo transfer fresh embryo transfer predictive value
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Predictive value of hypo-osmotic swelling test to identifyviable non-motile sperm 认领 引用 被引量：3
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作者 William M.Buckett 《Asian Journal of Andrology》 SCIE CAS 2003年第3期209-212,共4页
Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. Methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analy... Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. Methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analysis, eosin-nigrosin (EN) staining and the HOS test. A further EN stain was then performed on a HOS pre-treated aliquot and a total of 2000 further sperm examined. Results: The median sperm density was 5.1 million/mL (IQR 4.3-13.1) and the median motility was 3.0 % (IQR 0-7). Seven samples showed complete asthenozoospermia. Initial EN staining showed 59 % viability (range 48-69) despite the poor standard parameters and 47 % (range 33-61) in the complete asthenozoospermia subgroup. The HOS test showed 49.9 % reacted overall (range 40-59) and 41.7 % (range 22-61) in the complete asthenozoospermia subgroup. The combined HOS/EN stain showed the positive predictive value of the HOS test to identify viable sperm was 84.2 % overall and 79.7 % in the complete asthenozoospermia subgroup. Conclusion: The HOS test can effectively predict sperm viability in patients with severe and complete asthenozoospermia. 展开更多
关键词 azoospermia sperm spermmotility hypo-osmotic swelling (HOS) test sperm viability predictive value
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Predictive value of alarm symptoms in Rome IV irritable bowel syndrome:A multicenter cross-sectional study 认领 引用
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作者 Qian Yang Zhong-Cao Wei +10 位作者 Na Liu Yang-Lin Pan Xiao-Sa Jiang Xin-Xing Tantai Qi Yang Juan Yang Jing-Jie Wang Lei Shang Qiang Lin Cai-Lan Xiao Jin-Hai Wang 《World Journal of Clinical Cases》 SCIE 2022年第2期563-575,共13页
BACKGROUND Irritable bowel syndrome(IBS)is a common functional bowel disease that shares features with many organic diseases and cannot be accurately diagnosed by symptom-based criteria.Alarm symptoms have long been a... BACKGROUND Irritable bowel syndrome(IBS)is a common functional bowel disease that shares features with many organic diseases and cannot be accurately diagnosed by symptom-based criteria.Alarm symptoms have long been applied in the clinical diagnosis of IBS.However,no study has explored the predictive value of alarm symptoms in suspected IBS patients based on the latest Rome IV criteria.AIM To investigate the predictive value of alarm symptoms in suspected IBS patients based on the Rome IV criteria.METHODS In this multicenter cross-sectional study,we collected data from 730 suspected IBS patients evaluated at 3 tertiary care centers from August 2018 to August 2019.Patients with IBS-like symptoms who completed colonoscopy during the study period were initially identified by investigators through medical records.Eligible patients completed questionnaires,underwent laboratory tests,and were assigned to the IBS or organic disease group according to colonoscopy findings and pathology results(if a biopsy was taken).Independent risk factors for organic disease were explored by logistic regression analysis,and the positive predictive value(PPV)and missed diagnosis rate were calculated.RESULTS The incidence of alarm symptoms in suspected IBS patients was 75.34%.Anemia[odds ratio(OR)=2.825,95%confidence interval(CI):1.273-6.267,P=0.011],fecal occult blood[OR=1.940(95%CI:1.041-3.613),P=0.037],unintended weight loss(P=0.009),female sex[OR=0.560(95%CI:0.330-0.949),P=0.031]and marital status(P=0.030)were independently correlated with organic disease.The prevalence of organic disease was 10.41%in suspected IBS patients.The PPV of alarm symptoms for organic disease was highest for anemia(22.92%),fecal occult blood(19.35%)and unintended weight loss(16.48%),and it was 100%when these three factors were combined.The PPV and missed diagnosis rate for diagnosing IBS were 91.67%and 74.77%when all alarm symptoms were combined with Rome IV and 92.09%and 34.10%when only fecal occult blood,unintended weight loss and anemia were combined with Rome IV,respectively.CONCLUSION Anemia,fecal occult blood and unintended weight loss have high predictive value for organic disease in suspected IBS patients and can help identify patients requiring further examination but are not recommended as exclusion criteria for IBS. 展开更多
关键词 Alarm symptom Irritable bowel syndrome Predictive value Rome IV Organic disease
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Predictive value of serum alpha-fetoprotein for tumor regression after preoperative chemotherapy for rectal cancer 认领 引用
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作者 Da-Kui Zhang Jun Qiao +2 位作者 Shao-Xuan Chen Zhi-Yong Hou Jian-Zheng Jie 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第2期525-532,共8页
BACKGROUND Preoperative therapy is widely used in locally advanced rectal cancer.It can improve local control of rectal cancer.However,there are few indicators that can predict the effect of preoperative chemotherapy ... BACKGROUND Preoperative therapy is widely used in locally advanced rectal cancer.It can improve local control of rectal cancer.However,there are few indicators that can predict the effect of preoperative chemotherapy accurately.AIM To investigate whether the increase in serumα-fetoprotein(AFP)can predict better efficacy of preoperative chemotherapy.METHODS This was a retrospective study.We analyzed 125 patients admitted between 2017 and 2019 with locally advanced rectal cancer.All patients received six cycles of preoperative chemotherapy(mFOLFOX6 every 2 wk).Serum AFP of 26 patients rose slightly after three or four cycles of chemotherapy,and fell to normal again within 2 mo.The other 99 patients had a normal level of serum AFP during chemotherapy.Patients were divided into two groups(AFP risen and AFP normal).According to postoperative pathology,we compared tumor regression and complete response rate between the two groups.The primary outcome measure was the tumor regression grade(TRG)after chemotherapy.The difference in pathological complete response between the two groups was also investigated.RESULTS There were no tumor progression and distant metastasis in both groups during preoperative chemotherapy.Patients in the AFP risen group achieved better TRG 0/1 than those in the AFP normal group(61.5%vs 39.4%).The increase in AFP was a significant predictor for better tumor regression[χ2=4.144,odds ratio(OR)=2.666,P=0.04].In the AFP risen group,the complete response rate was 30.8%,which was higher than in the AFP normal group(30.8%vs 12.1%,χ2=4.542,OR=3.251,P=0.03).CONCLUSION Patients with a slight increase in serum AFP can achieve better tumor regression during preoperative chemotherapy,and are more likely to achieve pathological complete response. 展开更多
关键词 Rectal cancer Preoperative chemotherapy Alpha-fetoprotein Predictive value Tumor
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Predictive value of symptoms and demographics in diagnosing malignancy or peptic stricture 认领 引用
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作者 Iain A Murray Joanne Palmer +1 位作者 Carolyn Waters Harry R Dalton 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第32期4357-4362,共6页
AIM:To determine which features of history and demographics predict a diagnosis of malignancy or peptic stricture in patients presenting with dysphagia.METHODS:A prospective case-control study of 2000 consecutive refe... AIM:To determine which features of history and demographics predict a diagnosis of malignancy or peptic stricture in patients presenting with dysphagia.METHODS:A prospective case-control study of 2000 consecutive referrals(1031 female,age range:17-103 years) to a rapid access service for dysphagia,based in a teaching hospital within the United Kingdom,over 7 years.The service consists of a nurse-led telephone triage followed by investigation(barium swallow or gastroscopy),if appropriate,within 2 wk.Logistic regression analysis of demographic and clinical variables was performed.This includes age,sex,duration of dysphagia,whether to liquids or solids,and whether there are associated features(reflux,odynophagia,weight loss,regurgitation).We determined odds ratio(OR) for these variables for the diagnoses of malignancy and peptic stricture.We determined the value of the Edinburgh Dysphagia Score(EDS) in predicting cancer in our cohort.Multivariate logistic regression was performed and P 73 years,OR 1.1-3.3,age 73 years 11.8%,P 26 wk 2.5%,P 6 mo,OR 1.2-2.9,≤ 8 wk 9.8%,8-26 wk 10.6%,> 26 wk 15.7%,P 73 years 10.6%,P < 0.05).CONCLUSION:Malignancy and peptic stricture are frequent findings in those referred with dysphagia.The predictive value for associated features could help determine need for fast track investigation whilst reducing service pressures. 展开更多
关键词 Dysphagia Deglutition disorders Esophageal neoplasms Esophageal stenosis Gastroscopy Barium swallow Predictive value of tests
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Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy 认领 引用 被引量：12
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作者 Shahram Yousefpour Azary Heshmat Kalbasi +5 位作者 Ali Setayesh Mirhadi Mousavi Asad Hashemi Mahsa Khodadoostan Mohammad Reza Zali Amir Houshang Mohammad Alizadeh 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2011年第3期308-312,共5页
BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a r... BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a routine diagnostic procedure.The current study aimed to address the main determinants of CBD stone diagnosis in IOC among an Iranian population.METHODS:In a retrospective review database-based study conducted in Taleghani Hospital in Tehran between 2006 and 2008,baseline data and perioperative information of 2060 patients (male to female ratio 542:1518,mean age 53.7 years) who were candidates for cholecystectomy and underwent concomitant IOC for confirming CBD stones were reviewed.The predictive power of this procedure for diagnosis of abnormal biliary ducts with the focus on biliary stones was determined.RESULTS:Overall mortality and morbidity following cholecystectomy in the study population were 0.6% and 2.6%,respectively.Both early mortality and morbidity due to cholecystectomy were higher in male than female.The prevalence of CBD stones in IOC was 3.4% (5.2% in male and 2.8% in female,P=0.008).Among those without gallstones,8.7% had CBD stones and only 3.1% had concomitant gallstones and CBD stones.The main predictors of stone appearance as an abnormal feature of IOC during cholecystectomy were:advanced age (OR=1.022,P=0.001),male gender (OR=1.498,P=0.050),history of abdominal surgery (OR=1.543,P=0.040) and preoperative endoscopic retrograde cholangiopancreatography (OR=5.400,P<0.001).CONCLUSIONS:IOC is a safe and accurate method for the assessment of bile duct anatomy and stones.Therefore,the routine use of IOC within cholecystectomy seems reasonable and is recommended. 展开更多
关键词 intraoperative cholangiography common bile duct stone cholecystectomy predictive value diagnostic accuracy
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Prediction of Extreme Air Temperature and Wind Speed Along the Northern Sea Route(NSR)with Application for the Safety of Polar Vessels 认领 引用
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作者 CHAI Wei QI Jian-zhang +3 位作者 HE Lin Bernt J.LEIRA Chana SINSABVARODOM SHU Ya-qing 《China Ocean Engineering》 SCIE EI CSCD 2025年第4期744-754,共11页
Due to global warming and diminishing ice cover in Arctic regions,the northern sea route(NSR)has attracted increasing attention in recent years.Extreme cold temperatures and high wind speeds in Arctic regions present ... Due to global warming and diminishing ice cover in Arctic regions,the northern sea route(NSR)has attracted increasing attention in recent years.Extreme cold temperatures and high wind speeds in Arctic regions present substantial risks to vessels operating along the NSR.Consequently,analyzing extreme temperature and wind speed values along the NSR is essential for ensuring maritime operational safety in the region.This study analyzes wind and temperature data spanning 40 years,from 1981 to 2020,at four representative sites along the NSR for extreme value analysis.The average conditional exceedance rate(ACER)method and the Gumbel method are employed to estimate extreme wind speed and air temperature at these sites.Comparative analysis reveals that the ACER method provides higher accuracy and lower uncertainty in estimations.The predicted extreme wind speed for a 100-year return period is 30.36 m/s,with a minimum temperature of-56.66°C,varying across the four sites.Furthermore,the study presents extreme values corresponding to each return period,providing temperature extremes as a basis for guiding steel thickness specifications.These findings provide valuable reference for designing polar vessels and offshore structures,contributing to enhanced engineering standards for Arctic conditions. 展开更多
关键词 northern sea route(NSR) air temperature wind speed extreme value prediction ACER method
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Value of pre-treatment biomarkers in prediction of response to neoadjuvant endocrine therapy for hormone receptor-positive postmenopausal breast cancer 认领 引用 被引量：2
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作者 Min Ying Yingjian He +7 位作者 Meng Qi Bin Dong Aiping Lu Jinfeng Li Yuntao Xie Tianfeng Wang Benyao Lin Tao Ouyang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第4期397-404,共8页
Objective： To determine the predictive ability of biomarkers for responses to neoadjuvant endocrine therapy （NET） in postmenopausal breast cancer. Methods： Consecutive 160 postmenopausal women with T 1-3 N 0-1 M 0... Objective： To determine the predictive ability of biomarkers for responses to neoadjuvant endocrine therapy （NET） in postmenopausal breast cancer. Methods： Consecutive 160 postmenopausal women with T 1-3 N 0-1 M 0 hormone receptor （HR）-positive invasive breast cancer were treated with anastrozole for 16 weeks before surgery. New slides of tumor specimens taken before and after treatment were conducted centrally for biomarker analysis and classified using the Applied Imaging Ariol MB-8 system. The pathological response was evaluated using the Miller ＆ Payne classification. The cell cycle response was classified according to the change in the Ki67 index after treatment. Multivariable logistic regression analysis was used to calculate the combined index of the biomarkers. Receiver operating characteristic （ROC） curves were used to determine whether parameters may predict response. Results： The correlation between the pathological and cell cycle responses was low （Spearman correlation coefficient =0.241, P〈0.001; Kappa value =0.119, P=0.032）. The cell cycle response was significantly associated with pre-treatment estrogen receptor （ER） status （P=0.001）, progesterone receptor （PgR） status （P〈0.001）, human epidermal growth factor receptor 2 （Her-2） status （P=0.050） and the Ki67 index （P〈0.001）, but the pathological response was not correlated with these factors. Pre-treatment ER levels [area under the curve （AUC） =0.634, 95% confidence interval （95% CI）, 0.534-0.735, P=0.008] and combined index of pre-treatment ER and PgR levels （AUC =0.684, 95% CI, 0.591-0.776, P〈0.001） could not predict the cell cycle response, but combined index including per-treatment ER/PR/Her-2/Ki67 expression levels could （AUC =0.830, 95% CI, 0.759-0.902, P〈0.001）. Conclusions： The combined use of pre-treatment ER/PgR/Her-2/Ki67 expression levels, instead of HR expression levels, may predict the cell cycle response to NET. 展开更多
关键词 Breast cancer neoadjuvant endocrine therapy （NET） responsiveness predictive value
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Predictive value of SinoSCORE on in-hospital mortality and postoperative complications after coronary artery bypass surgery 认领 引用
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作者 苏丕雄 《外科研究与新技术（中英文）》 2011年第3期181-182,共2页
Objective To evaluate the performance of the Sino System for Coronary Operative Risk Evaluation (SinoSCORE) on in hospital mortality and postoperative complications in patients undergoing coronary artery bypass grafti... Objective To evaluate the performance of the Sino System for Coronary Operative Risk Evaluation (SinoSCORE) on in hospital mortality and postoperative complications in patients undergoing coronary artery bypass grafting (CABG) in a single heart center. Methods From January 2007 to December 2008,clinical information of 201 consecutive patients undergoing isolated CABG in our hospital was collected. The SinoSCORE was used to 展开更多
关键词 CABG Predictive value of SinoSCORE on in-hospital mortality and postoperative complications after coronary artery bypass surgery IABP
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Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy:A retrospective cohort study 认领 引用 被引量：1
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作者 Ji-Ming Ma Peng-Fei Wang +6 位作者 Liu-Qing Yang Jun-Kai Wang Jian-Ping Song Yu-Mei Li Yan Wen Bing-Jun Tang Xue-Dong Wang 《World Journal of Gastroenterology》 SCIE CAS 2025年第8期9-23,共15页
BACKGROUND The International Study Group of Pancreatic Surgery has established the defi-nition and grading system for postpancreatectomy acute pancreatitis(PPAP).There are no established machine learning models for pr... BACKGROUND The International Study Group of Pancreatic Surgery has established the defi-nition and grading system for postpancreatectomy acute pancreatitis(PPAP).There are no established machine learning models for predicting PPAP following pancreaticoduodenectomy(PD).AIM To explore the predictive model of PPAP,and test its predictive efficacy to guide the clinical work.METHODS Clinical data from consecutive patients who underwent PD between 2016 and 2024 were retrospectively collected.An analysis of PPAP risk factors was performed,various machine learning algorithms[logistic regression,random forest,gradient boosting decision tree,extreme gradient boosting,light gradient boosting machine,and category boosting(CatBoost)]were utilized to develop predictive models.Recursive feature elimination was employed to select several variables to achieve the optimal machine algorithm.RESULTS The study included 381 patients,of whom 88(23.09%)developed PPAP.PPAP patients exhibited a significantly higher incidence of postoperative pancreatic fistula(55.68%vs 14.68%,P<0.001),grade C postoperative pancreatic fistula(9.09%vs 1.37%,P=0.001).The CatBoost algorithm outperformed other algorithms with a mean area under the receiver operating characteristic curve of 0.859[95%confidence interval(CI):0.814-0.905]in the training cohort and 0.822(95%CI:0.717-0.927)in the testing cohort.According to shapley additive explanations analysis,pancreatic texture,main pancreatic duct diameter,body mass index,estimated blood loss,and surgery time were the most important variables based on recursive feature elimination.The CatBoost algorithm based on selected variables demonstrated superior performance,with an area under the receiver operating characteristic curve of 0.837(95%CI:0.788-0.886)in the training cohort and 0.812(95%CI:0.697-0.927)in the testing cohort.CONCLUSION We developed the first machine learning-based predictive model for PPAP following PD.This predictive model can assist surgeons in anticipating and managing this complication proactively. 展开更多
关键词 Pancreaticoduodenectomy Postoperative complication Acute pancreatitis Machine learning Predictive value
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Predictive value of diaphragm ultrasound for mechanical ventilation outcome in patients with acute exacerbation of chronic obstructive pulmonary disease 认领 引用 被引量：7
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作者 Lei-Lei Qu Wen-Ping Zhao +1 位作者 Ji-Ping Li Wei Zhang 《World Journal of Clinical Cases》 SCIE 2024年第26期5893-5900,共8页
BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is often combined with respiratory failure,which increases the patient's morbidity and mortality.Diaphragm ultrasound(DUS)has developed... BACKGROUND Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)is often combined with respiratory failure,which increases the patient's morbidity and mortality.Diaphragm ultrasound(DUS)has developed rapidly in the field of critical care in recent years.Studies with DUS monitoring diaphragm-related rapid shallow breathing index have demonstrated important results in guiding intensive care unit patients out of the ventilator.Early prediction of the indications for withdrawal of non-invasive ventilator and early evaluation of patients to avoid or reduce disease progression are very important.AIM To explore the predictive value of DUS indexes for non-invasive ventilation outcome in patients with AECOPD.METHODS Ninety-four patients with AECOPD who received mechanical ventilation in our hospital from January 2022 to December 2023 were retrospectively analyzed,and they were divided into a successful ventilation group(68 cases)and a failed ventilation group(26 cases)according to the outcome of ventilation.The clinical data of patients with successful and failed noninvasive ventilation were compared,and the independent predictors of noninvasive ventilation outcomes in AECOPD patients were identified by multivariate logistic regression analysis.RESULTS There were no significant differences in gender,age,body mass index,complications,systolic pressure,heart rate,mean arterial pressure,respiratory rate,oxygen saturation,partial pressure of oxygen,oxygenation index,or time of inspiration between patients with successful and failed mechanical ventilation(P>0.05).The patients with successful noninvasive ventilation had shorter hospital stays and lower partial pressure of carbon dioxide(PaCO2)than those with failed treatment,while potential of hydrogen(pH),diaphragm thickening fraction(DTF),diaphragm activity,and diaphragm movement time were significantly higher than those with failed treatment(P<0.05).pH[odds ratio(OR)=0.005,P<0.05],PaCO2(OR=0.430,P<0.05),and DTF(OR=0.570,P<0.05)were identified to be independent factors influencing the outcome of mechanical ventilation in AECOPD patients.CONCLUSION The DUS index DTF can better predict the outcome of non-invasive ventilation in AECOPD patients. 展开更多
关键词 Diaphragm ultrasound Mechanical ventilation Acute exacerbation of chronic obstructive pulmonary disease Predictive value Diaphragm thickening fraction Diaphragm activity
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