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Pharmacological mechanisms of natural products with antidepressant effects:A focus on the programmed cell death regulation 认领 引用
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作者 Guangheng Zhang Shimeng Lv +9 位作者 Shengchuan Bao Weijie Zhao Yunhao Yi Haonan Gao Xia Zhong Xiangyu Li Fengzhao Liu Yitong Lu Siyuan Sun Jing Teng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期120-141,共22页
Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increase... Depression is a prevalent mental disorder characterized by persistent disinterest and a depressed mood,with severe cases potentially leading to suicide.In recent years,the incidence of depression has steadily increased,making it the second-largest global health burden.The pathogenesis of depression involves a series of complex pathological mechanisms,although the key underlying causes remain unclear.Programmed cell death(PCD),including apoptosis,autophagy,pyroptosis,ferroptosis,and necroptosis,involves highly organized gene expression processes that may influence the occurrence and development of depression by regulating cellular fate.Furthermore,numerous studies have shown that natural products can modulate PCDs through various signaling pathways,presenting significant potential for managing depression.Natural products offer benefits such as cost-effectiveness,fewer side effects,and other advantages,making them viable supplements or alternatives to traditional antidepressant drugs.To explore this potential,we reviewed studies demonstrating the antidepressant effects of natural products through multi-target modulation of PCDs.In addition,we discussed the toxicity and clinical applications of these natural products.This study highlights that diverse core biological pathways and targets are involved in determining the fate of depression-associated brain cells,including the PI3K/Akt signaling pathway,caspase-8,GSDMD,and others.In conclusion,the multi-target mechanisms of PCD regulation by natural products may provide a promising foundation for the future development of novel antidepressant medications. 展开更多
关键词 Depression Pharmacological mechanism Programmed cell death Natural products Antidepressant
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Patterns and mechanisms of programmed cell death in bloom-forming Microcystis aeruginosa induced by potent allelochemical juglone 认领 引用
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作者 Xu YANG Jinyuan CHEN +4 位作者 Ang GAO Jinting LI Yulu HU Haiying WANG Xin ZHANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2026年第3期1116-1131,共16页
Harmful algal blooms(HABs)caused by Microcystis aeruginosa are a major global threat to the aquatic environment and public health.Allelochemicals derived from aquatic and terrestrial plants are emerging weapons for er... Harmful algal blooms(HABs)caused by Microcystis aeruginosa are a major global threat to the aquatic environment and public health.Allelochemicals derived from aquatic and terrestrial plants are emerging weapons for eradicating these blooms.Here,juglone outperformed the most reported allelochemicals in terms of algicidal activity against M.aeruginosa,with a half-maximal inhibitory concentration(IC50)of 0.078 mg/L.The algal growth suppression resulted from the activation of programmed cell death(PCD)upon juglone treatment.Ultrastructural changes of juglone-induced cyanobacterial cells were characterized by marked cytoplasmic vacuolization,as indicated by transmission electron microscopy(TEM)and scanning electron microscope(SEM).Dose-and timedependent biochemical features of M.aeruginosa in response to juglone included the increase in DNA fragmentation,caspase-3-like and caspase-9-like activities,phosphatidylserine externalization and chromatin condensation.Morphological and biochemical analyses revealed two modes of cell death,including apoptotic-like and autophagic-like PCD.The juglone-induced PCD was associated with increased reactive oxygen species(ROS)and nitric oxide(NO)as potential signal molecules.The blockage of the electron flow beyond(primary quinone acceptor)QA at photosystem II(PSII)acceptor side mediated the generation of ROS in M.aeruginosa exposed to juglone.Cotreatments with sodium tungstate,a nitrate reductase(NR)inhibitor,with the juglone successfully reduced NO production,suggesting that NO production in M.aeruginosa cells was mainly through NR pathway.The current study sheds light on the inhibition and action mode of juglone on M.aeruginosa from the perspective of PCD,as well as its potential for controlling cyanobacterial blooms. 展开更多
关键词 juglone Microcystis aeruginosa programmed cell death(PCD) reactive oxygen species(ROS) nitric oxide(NO)
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Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors 认领 引用
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作者 Rui Guo Meng Gao 《World Journal of Gastroenterology》 SCIE CAS 2026年第18期51-64,共14页
BACKGROUND The neutrophil-lymphocyte ratio(NLR)is an accessible inflammatory biomarker with emerging prognostic value in oncology.AIM To evaluate the predictive value of pretreatment NLR in patients with advanced hepa... BACKGROUND The neutrophil-lymphocyte ratio(NLR)is an accessible inflammatory biomarker with emerging prognostic value in oncology.AIM To evaluate the predictive value of pretreatment NLR in patients with advanced hepatocellular carcinoma(aHCC)undergoing therapy with programmed cell death 1(PD-1)inhibitors.METHODS This retrospective analysis included 234 patients with aHCC who received PD-1 inhibitor therapy between January 2022 and June 2024.The patients were categorized into good or poor prognosis groups according to overall survival relative to the median.The optimal NLR cutoff(3.165)was determined by receiver operator characteristic analysis,defining the low(≤3.165)and high(>3.165)NLR groups.Hematological parameters were measured from blood samples collected within 1 week before treatment initiation.Radiologic assessments were conducted every 6-9 weeks in accordance with Response Evaluation Criteria in Solid Tumors v1.1.Progression-free survival(PFS)and overall survival(OS)were assessed during follow-up.RESULTS The high NLR group had significantly worse tumor burden and more advanced disease compared with the low NLR group.Multivariate analysis identified high NLR as an independent risk factor for poor prognosis(odds ratio=4.365,P<0.001)with the highest predictive accuracy(area under the curve=0.785).The low NLR group demonstrated superior objective response rate(35.66%vs 16.19%,P=0.001)and disease control rate(71.32%vs 57.14%,P=0.024)and had significantly longer median progression-free survival(7.52 months vs 5.21 months,P<0.001)and overall survival(16.84 months vs 11.05 months,P<0.001).Cox regression confirmed that high NLR independently predicted poor PFS(hazard ratio=2.084)and OS(hazard ratio=2.421).CONCLUSION Pretreatment NLR is a powerful,independent prognostic biomarker for patients with aHCC receiving PD-1 inhibitor treatment. 展开更多
关键词 Neutrophil-lymphocyte ratio Hepatocellular carcinoma Programmed cell death 1 inhibitor Prognosis Biomarker Immunotherapy
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Up-regulated programmed cell death protein-1/its ligand 1 expression promotes metabolic dysfunction-associated steatotic liver disease malignant progression 认领 引用 被引量：1
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作者 Min Xu Tian-Tian Ruan +5 位作者 Hao Tang Rong-Fei Fang Wen-Li Sai Qun Xie Deng-Fu Yao Min Yao 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第5期1-8,共8页
This editorial focuses on the recent article by Yang et al in the World Journal of Gastrointestinal Oncology,which highlights the role of interlukin-17A in promoting hepatocellular carcinoma(HCC)progression by up-regu... This editorial focuses on the recent article by Yang et al in the World Journal of Gastrointestinal Oncology,which highlights the role of interlukin-17A in promoting hepatocellular carcinoma(HCC)progression by up-regulated programmed cell death protein-1(PD-1)/programmed cell death protein ligand-1(PD-L1)expression.Previous,the high PD-1/PD-L1 level was due to hepatitis virus infection leading to systemic innate immune tolerance and cluster of differen-tiation 8+T cells exhaustion,ultimately leading to HCC.Recently,interesting studies have found that the malignant progression of metabolic dysfunction-associated steatotic/fatty liver disease(MASLD/MAFLD),that is former nonalcoholic fatty liver disease,was achieved by up-regulated PD-L1 level that was activated the cGAS-STING pathway under lipid accumulation with mito-chondrial DNA overflow and up-regulated PD-1/PD-L1 to promote MASLD malignant transformation via immune escape.These data suggested that PD-1 or PD-L1 should be a promising target for preventing or delaying non-viral liver disease malignant progression except of antiviral therapy for HCC. 展开更多
关键词 Hepatocytes Metabolic dysfunction-associated steatotic/fatty liver disease Programmed cell death protein-1 Programmed cell death protein ligand-1 Immune escape
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Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant 认领 引用
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作者 Marina A Senchukova Evgeniya Yu Zubareva +1 位作者 Natalia V Saidler Lyubov V Krivolapova 《World Journal of Experimental Medicine》 2025年第4期215-237,共23页
BACKGROUND Recent studies have indicated that an antibody against programmed cell death protein 1-ligand 1(PDCD1-LG1),a new marker of programmed cell death-ligand 1 expression,is promising for studying the mechanisms ... BACKGROUND Recent studies have indicated that an antibody against programmed cell death protein 1-ligand 1(PDCD1-LG1),a new marker of programmed cell death-ligand 1 expression,is promising for studying the mechanisms of breast cancer(BC)progression and resistance to chemotherapy.AIM To compare the features of PDCD1-LG1 expression in chemoresistant luminal A BC and BC with high Ki67 indices.METHODS This prospective single-center observational cohort study included 148 patients with newly diagnosed primary resectable BC.The tumor sections were stained with antibodies against PDCD1-LG1.The statistical calculations were performed using Statistica software version 12.0.P<0.05 was considered statistically significant.RESULTS Cytoplasmic PDCD1-LG1(cPDCD1-LG1)expression was detected in the nonneoplastic epithelium,tumor cells(TCs)and immune cells(ICs).A lack of cPDCD1-LG1 expression in≥20% of TCs and a PDCD1-LG1+IC score≥10%were associated with aggressive BC characteristics,including tumor G3,estrogen receptor-negative status,overexpression of human epidermal growth factor receptor 2(HER2+),luminal B HER2+BC,nonluminal HER2+BC and triplenegative BC.The lack of cPDCD1-LG1 expression in<20% of the TCs,in combination with a PDCD1-LG1+IC score<10% and G1,was characteristic of chemoresistant luminal A BC,whereas the lack of cPDCD1-LG1 expression in≥20% of the TCs,combined with a PDCD1-LG1+IC score≥10%,was a predictor of high BC sensitivity to chemotherapy.CONCLUSION These results indicate that both the lack of cPDCD1 LG1 in TCs and the PDCD1 LG1 IC score and their combination may be important for assessing BC prognosis and sensitivity to chemotherapy. 展开更多
关键词 Breast cancer Chemoresistance Programmed death-ligand 1 Programmed cell death protein 1-ligand 1 Сytoplasmic programmed cell death protein 1 ligand 1
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The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia 认领 引用 被引量：3
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作者 Hao Wu Yingxue Han +6 位作者 Jikang Liu Rong Zhao Shizhen Dai Yajun Guo Nan Li Feng Yang Shenming Zeng 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第1期121-135,共15页
Background Follicular atresia significantly impairs female fertility and hastens reproductive senescence.Apoptosis of granulosa cells is the primary cause of follicular atresia.Pyroptosis and necroptosis,as additional... Background Follicular atresia significantly impairs female fertility and hastens reproductive senescence.Apoptosis of granulosa cells is the primary cause of follicular atresia.Pyroptosis and necroptosis,as additional forms of pro-grammed cell death,have been reported in mammalian cells.However,the understanding of pyroptosis and necrop-tosis pathways in granulosa cells during follicular atresia remains unclear.This study explored the effects of pro-grammed cell death in granulosa cells on follicular atresia and the underlying mechanisms.Results The results revealed that granulosa cells undergo programmed cell death including apoptosis,pyroptosis,and necroptosis during follicular atresia.For the first time,we identified the formation of a PANoptosome com-plex in porcine granulosa cells.This complex was initially identified as being composed of ZBP1,RIPK3,and RIPK1,and is recruited through the RHIM domain.Additionally,we demonstrated that caspase-6 is activated and cleaved,interacting with RIPK3 as a component of the PANoptosome.Heat stress may exacerbate the activation of the PANop-tosome,leading to programmed cell death in granulosa cells.Conclusions Our data identified the formation of a PANoptosome complex that promoted programmed cell death in granulosa cells during the process of follicular atresia.These findings provide new insights into the molecular mechanisms underlying follicular atresia. 展开更多
关键词 Follicular atresia Granulosa cells PANoptosome Programmed cell death
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Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss:Ferroptosis,Necroptosis,and Pyroptosis 认领 引用 被引量：1
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作者 Shasha Zhang Hairong Xiao +7 位作者 Yanqin Lin Xujun Tang Wei Tong Buwei Shao He Li Lei Xu Xiaoqiong Ding Renjie Chai 《Neuroscience Bulletin》 SCIE CAS CSCD 2025年第6期1085-1102,共18页
Sensorineural hearing loss(SNHL),the most commonly-occurring form of hearing loss,is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea.Numerous environmental and physiolog... Sensorineural hearing loss(SNHL),the most commonly-occurring form of hearing loss,is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea.Numerous environmental and physiological factors have been shown to cause acquired SNHL,such as ototoxic drugs,noise exposure,aging,infections,and diseases.Several programmed cell death(PCD)pathways have been reported to be involved in SNHL,especially some novel PCD pathways that have only recently been reported,such as ferroptosis,necroptosis,and pyroptosis.Here we summarize these PCD pathways and their roles and mechanisms in SNHL,aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways. 展开更多
关键词 Sensorineural hearing loss Programmed cell death Ferroptosis Necroptosis Pyroptosis
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Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+T cell response 认领 引用 被引量：1
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作者 Yang-Yang Ma Xiao-Hua Wang +2 位作者 Jian-Ying Zeng Ji-Bing Chen Li-Zhi Niu 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第3期237-245,共9页
BACKGROUND Irreversible electroporation(IRE)is a novel local tumor ablation approach with the potential to activate the host’s immune system.However,this approach is insufficient to prevent cancer progression,and com... BACKGROUND Irreversible electroporation(IRE)is a novel local tumor ablation approach with the potential to activate the host’s immune system.However,this approach is insufficient to prevent cancer progression,and complementary approaches are required for effective immunotherapy.AIM To assess the immunomodulatory effects and mechanism of IRE combined antiprogrammed cell death protein 1(PD-1)treatment in subcutaneous pancreatic cancer models.METHODS C57BL-6 tumor-bearing mice were randomly divided into four groups:Control group;IRE group;anti-PD-1 group;and IRE+anti-PD-1 group.Tumor-infiltrating T,B,and natural killer cell levels and plasma concentrations of T helper type 1 cytokines(interleukin-2,interferon-γ,and tumor necrosis factor-α)were evaluated.Real-time PCR was used to determine the expression of CD8(marker of CD8+T cells)in tumor tissues of the mice of all groups at different points of time.The growth curves of tumors were drawn.RESULTS The results demonstrated that the IRE+anti-PD-1 group exhibited significantly higher percentages of T lymphocyte infiltration,including CD4+and CD8+T cells compared with the control group.Additionally,the IRE+anti-PD-1 group showed increased infiltration of natural killer and B cells,elevated cytokine levels,and higher CD8 mRNA expression.Tumor volume was significantly reduced in the IRE+anti-PD-1 group,indicating a more pronounced therapeutic effect.CONCLUSION The combination of IRE and anti-PD-1 therapy promotes CD8+T cell immunity responses,leading to a more effective reduction in tumor volume and improved therapeutic outcomes,which provides a new direction for ablation and immunotherapy of pancreatic cancer. 展开更多
关键词 Irreversible electroporation Pancreatic cancer Programmed cell death protein 1 blockade CD8+T cell Anticancer immunity
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Programmed cell death receptor 1 inhibitor Pembrolizumab in the treatment of advanced gastric cancer 认领 引用
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作者 Xue-Mei Yi Hong-Qiao Cai Yan Jiao 《World Journal of Gastrointestinal Surgery》 SCIE 2025年第2期16-19,共4页
This editorial discusses Christodoulidis et al's article,which appeared in the most recent edition.The clinical trials have demonstrated the programmed cell death receptor 1(PD-1)inhibitor Pembrolizumab involved c... This editorial discusses Christodoulidis et al's article,which appeared in the most recent edition.The clinical trials have demonstrated the programmed cell death receptor 1(PD-1)inhibitor Pembrolizumab involved combination therapy can improve the efficacy of advanced gastric cancer(AGC).Pembrolizumab combined with chemotherapy can enhance its sensitivity,and further eliminate tumor cells that develop resistance to chemotherapy.The combination of Pembrolizumab and Trastuzumab targeting human epidermal growth factor receptor 2 showed improved prognosis.The overall toxic effects of Pembrolizumab are significantly lower than traditional chemotherapy,and the safety is controllable.PD-1 inhibitor Pembrolizumab sheds a light on the treatment of AGC and brings new hope to the clinical practice. 展开更多
关键词 Programmed cell death receptor 1 inhibitor Pembrolizumab Advanced gastric cancer Chemotherapy Trastuzumab
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Mechanisms of programmed cell death in livestock follicular development and atresia:a review 认领 引用
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作者 Shunshun Han Yimeng Wei +5 位作者 Yuanhang Wei Xiyu Zhao Yuqi Chen Can Cui Yao Zhang Huadong Yin 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第6期2519-2538,共20页
Programmed cell death(PCD),including autophagy,apoptosis,and ferroptosis,is a fundamental biological process that plays a critical role in follicular development and atresia in livestock.In ovaries,the vast majority o... Programmed cell death(PCD),including autophagy,apoptosis,and ferroptosis,is a fundamental biological process that plays a critical role in follicular development and atresia in livestock.In ovaries,the vast majority of follicles undergo atresia,while only a small fraction reach ovulation.Emerging evidence suggests that these three forms of PCD are intricately involved in regulating follicular fate through distinct yet interconnected molecular mechanisms.This review summarizes recent advances in understanding the roles of autophagy,apoptosis,and ferroptosis in follicular development and atresia,with a focus on their molecular mechanisms and interactions.By elucidating the complex regulatory networks of PCD in ovarian physiology,this review aims to provide new insights into improving reproductive efficiency in livestock through targeted modulation of these pathways. 展开更多
关键词 Follicular atresia Follicular development Livestock reproduction Programmed cell death
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Real-time SERS analysis of programmed cell death patterns based on black Phosphorus-gold nanoparticles 认领 引用
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作者 Jieyi Chen Binggang Ye +7 位作者 Ranran Fan Jiaqi Liu Yaru Han Haolin Chen Wen Zhang Zhouyi Guo Zhiming Liu Huiqing Zhong 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第4期175-189,共15页
Programmed cell death(PCD)plays a crucial role in the biological processes of living organisms and occurs in various forms,such as apoptosis,necroptosis and ferroptosis.However,traditional methods for PCD analysis are... Programmed cell death(PCD)plays a crucial role in the biological processes of living organisms and occurs in various forms,such as apoptosis,necroptosis and ferroptosis.However,traditional methods for PCD analysis are time-consuming and complex.In this paper,we propose a facile surface-enhanced Raman spectroscopy(SERS)-based strategy for the real-time analysis of three PCD patterns utilizing black phosphorus–gold nanoparticles(BP–Au NPs)as the ultrasensitive unlabeled Raman probe.BP–Au NPs,which possess excellent biocompatibility,are capable of detecting dye molecules at concentrations as low as 5×10-8M and remain stable for at least one week in different physiological environments.In view of this,BP–Au NPs-based SERS technique can distinguish the tiny differences in the molecular fingerprints of cancer cells undergoing three PCD patterns(apoptosis,necroptosis and ferroptosis)triggered by doxorubicin,shikonin and erastin,respectively.We also have real-time monitoring of the intracellular molecular events during PCD,which spy the fluctuations of some typical SERS bands assigned to protein,DNA and lipid,revealing the unique phenotypic characteristics of each PCD pattern.This strategy provides a detailed and comprehensive analysis of the mechanisms of drug-induced PCD at the Raman level. 展开更多
关键词 Programmed cell death surface-enhanced Raman spectroscopy black phosphorus-gold nanoparticles
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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma 认领 引用
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作者 Shi-Qiong Zhou Peng Wan +3 位作者 Seng Zhang Yuan Ren Hong-Tao Li Qing-Hua Ke 《World Journal of Clinical Oncology》 2025年第2期29-35,共7页
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment opti... BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves insufficient.Immunotherapy,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on PDAC.This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.AIM To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic adenocarcinoma.METHODS Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer therapy.Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable toxicity.Participants in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles.Between June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy alone.RESULTS The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P0.05).CONCLUSION The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC,meriting further investigation. 展开更多
关键词 Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma
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Research progress regarding programmed cell death 1/programmed cell death ligand 1 inhibitors combined with targeted therapy for treating hepatocellular carcinoma 认领 引用
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作者 Lin-Lin Zheng Chang-Cheng Tao +4 位作者 Zong-Gui Tao Kai Zhang An-Ke Wu Jian-Xiong Wu Wei-Qi Rong 《World Journal of Gastrointestinal Surgery》 SCIE 2021年第10期1136-1148,共13页
In recent years,a number of targeted therapeutic agents have achieved success in phase III trials in patients with advanced hepatocellular carcinoma(HCC),including sorafenib,lenvatinib,and regorafenib.Immunotherapy is... In recent years,a number of targeted therapeutic agents have achieved success in phase III trials in patients with advanced hepatocellular carcinoma(HCC),including sorafenib,lenvatinib,and regorafenib.Immunotherapy is considered to be an effective treatment for advanced HCC.Immune checkpoint inhibitors targeting programmed cell death 1(PD-1)/programmed cell death ligand 1(PDL1)are important antitumor immunotherapy agents that represent breakthroughs in the treatment of advanced HCC.However,treating advanced HCC is still a great challenge,and the need for new treatments remains urgent.This review briefly summarizes the research progress in the use of PD-1/PD-L1 inhibitors combined with targeted therapy for treating HCC. 展开更多
关键词 Programmed cell death 1/programmed cell death ligand 1 inhibitors Targeted therapy Hepatocellular carcinoma Programmed cell death 1 Programmed cell death ligand 1
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Programmed cell death,antioxidant response and oxidative stress in wheat f lag leaves induced by chemical hybridization agent SQ-1 认领 引用 被引量：13
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作者 WANG Shu-ping ZHANG Gai-sheng +7 位作者 SONG Qi-lu ZHANG Ying-xin LI Ying GUO Jia-lin CHEN Zheng NIU Na MA Shou-cai WANG Jun-wei 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2016年第1期76-86,共11页
Male sterility induced by a chemical hybridization agent(CHA)is an important tool for utilizing crop heterosis.Leaves,especially the flag leaves,as CHA initial recipients play a decisive role in inducing male sterilit... Male sterility induced by a chemical hybridization agent(CHA)is an important tool for utilizing crop heterosis.Leaves,especially the flag leaves,as CHA initial recipients play a decisive role in inducing male sterility.To investigate effects of different treatment times of CHA-SQ-1 used,morphological,biochemical and physiological responses of wheat flag leaves were detected in thistudy.CHA induced programmed cell death(PCD)as shown in terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling(TUNEL)and DNA laddering analysis.In the early phase,CHA-SQ-1 trig-gered organelle changes arid PCD in wheat leaves accompanied by excess production of reactive oxygen species(O2-and H202)and down-regulation of the activities of superoxide dismutase(SOD),catalase(CAT)and guaiacol peroxidase(POD).Meanwhile,leaf cell DNAs showed ladder-like patterns on agarose gel,indicating that CHA-SQ-1 led to the activation of the responsible endonuclease.The oxidative stress assays showed that lipid peroxidation was strongly activated and photosynthesis was obviously inhibited in SQ-l-induced leaves.However,CHA contents in wheat leaves gradually reduced along with the time CHA-SQ-1 applied.Young flags returned to an oxidative/antioxidative balance and ultimately developed into mature green leaves.These results provide explanation of the relations between PCD and anther abortion and practical application of CHA for hybrid breeding. 展开更多
关键词 wheat flag leaf chemical hybridization agent SQ-1 programmed cell death antioxidant response oxidative stress
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Reduced Expression of Programmed Cell Death 5 Protein in Tissue of Human Prostate Cancer 认领 引用 被引量：15
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作者 Yue-jun Du Lin Xiong +2 位作者 Yan Lou Wan-long Tan Shao-bin Zheng 《Chinese Medical Sciences Journal》 CAS 2009年第4期241-245,共5页
Objective To investigate the expression of programmed cell death 5 （PDCD5） in tissues of normal human prostate （NP）, benign prostatic hyperplasia （BPH）, and prostate cancer （PCa） in order to assess the clinica... Objective To investigate the expression of programmed cell death 5 （PDCD5） in tissues of normal human prostate （NP）, benign prostatic hyperplasia （BPH）, and prostate cancer （PCa） in order to assess the clinical role of PDCD5 in PCa. Methods PDCD5 expression was determined by EnVision immunohistochemical staining in forma-lin-fixed and paraffin-embedded specimens obtained from 12 subjects with NP, 22 with BPH, and 22 with PCa. In addition, PCa cases were classified as low/middle-risk （Gleason sumS7） and high-risk （Gleason sum〉7） on the basis of Gleason grade. Positive expression rates and intensity of PDCD5 protein were observed under light microscope and analyzed with computer imaging technique. Expression of PDCD5 was compared among different prostatic tissues. Results The expression of PDCD5 was significantly lower in tissue of PCa than in tissues of NP and BPH （P〈0.01）. However, there was no significant difference in PDCD5 expression between tissues of NP and BPH. In addition, the expression of PDCD5 was further downregulated with the increase of Gleason sum in PCa. Conclusions By downregulating apoptosis, low PDCD5 expression may play an important role in the occurrence and development of PCa. PDCD5 is supposed to have a potential clinical value to be a new predictor of progression and target of gene therapy in PCa. 展开更多
关键词 prostate cancer apoptosis programmed cell death 5
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Function of flavonoids on different types of programmed cell death and its mechanism:a review 认领 引用 被引量：5
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作者 Preethi Vetrivel Seong Min Kim +4 位作者 Venu Venkatarame Gowda Saralamma Sang Eun Ha Eun Hee Kim Tae Sun Min Gon Sup Kim 《Journal of Biomedical Research》 CAS CSCD 2019年第6期363-370,共8页
Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the body.Programmed cell death(PCD)is a crucial component of several development and defense mechanisms... Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the body.Programmed cell death(PCD)is a crucial component of several development and defense mechanisms.PCD is also important in terms of aging which avoids the accumulation of cellular damage by maintaining cell division.Depending on the execution of cell death and its role in destruction,PCD is categorized into several subtypes.The major different forms of PCD in animals are apoptosis,autophagy and necrosis,which can be distinct in morphological terms.More intense investigations of cell death have given close insight showing other important types of cellular destruction and their pivotal roles in treating disease conditions like cancer.Flavonoids have been acquired a great interest for disease therapies and chemoprevention through activation of several PCD mechanisms.The significant potential of natural flavonoids in the induction of distinct signaling cascades is being a massive approach for targeting uncontrolled cell growth.For these reasons,understanding PCD mechanisms is a promising approach for the interventions in treating cancer.Thus,it is intriguing that understanding the different forms of PCD mechanism induced by flavonoids with more accurate descriptions on the biochemical and cellular processes are gaining more significance in cancer research.Here,we provide a brief overview on the different types of PCD and aim to discuss the functional role of flavonoids in promoting different types of cell death as well as an extensive brief review on their mechanism of action has been highlighted. 展开更多
关键词 programmed cell death apoptosis necrosis autophagy anoikis
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Floret-specific differences in gene expression and support for the hypothesis that tapetal degeneration of Zea mays L. occurs via programmed cell death 认领 引用 被引量：4
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作者 David S. Skibbe Xiujuan Wang +3 位作者 Lisa A. Borsuk Daniel A. Ashlock Dan Nettleton Patrick S. Schnable 《Journal of Genetics and Genomics》 SCIE CAS 北大核心 2008年第10期603-616,共14页
The maize （Zea mays） spikelet consists of two florets, each of which contains three developmentally synchronized anthers. Morphologically, the anthers in the upper and lower florets proceed through apparently simila... The maize （Zea mays） spikelet consists of two florets, each of which contains three developmentally synchronized anthers. Morphologically, the anthers in the upper and lower florets proceed through apparently similar developmental programs. To test for global differences in gene expression and to identify genes that are coordinately regulated during maize anther development, RNA samples isolated from upper and lower floret anthers at six developmental stages were hybridized to cDNA microarrays. Approximately 9% of the tested genes exhibited statistically significant differences in expression between anthers in the upper and lower florets. This finding indicates that several basic biological processes are differentially regulated between upper and lower floret anthers, including metabolism, protein synthesis and signal transduction. Genes that are coordinately regulated across anther development were identified via cluster analysis. Analysis of these results identified stage-specific, early in development, late in development and bi-phasic expression profiles. Quantitative RT-PCR analysis revealed that four genes whose homologs in other plant species are involved in programmed cell death are up-regulated just prior to the time the tapetum begins to visibly degenerate （i.e., the mid-microspore stage）. This finding supports the hypothesis that developmentally normal tapetal degeneration occurs via programmed cell death. 展开更多
关键词 anther development programmed cell death microarray maize
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Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications 认领 引用 被引量：5
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作者 Xi-Min Hu Qi Zhang +7 位作者 Rui-Xin Zhou Yan-Lin Wu Zhi-Xin Li Dan-Yi Zhang Yi-Chao Yang Rong-Hua Yang Yong-Jun Hu Kun Xiong 《World Journal of Stem Cells》 SCIE 2021年第5期386-415,共30页
Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and functional recovery.However,transplanted stem cells show a high death percentage,creating challenges to successful transplantat... Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and functional recovery.However,transplanted stem cells show a high death percentage,creating challenges to successful transplantation and prognosis.Thus,it is necessary to investigate the mechanisms underlying stem cell death,such as apoptotic cascade activation,excessive autophagy,inflammatory response,reactive oxygen species,excitotoxicity,and ischemia/hypoxia.Targeting the molecular pathways involved may be an efficient strategy to enhance stem cell viability and maximize transplantation success.Notably,a more complex network of cell death receives more attention than one crucial pathway in determining stem cell fate,highlighting the challenges in exploring mechanisms and therapeutic targets.In this review,we focus on programmed cell death in transplanted stem cells.We also discuss some promising strategies and challenges in promoting survival for further study. 展开更多
关键词 Programmed cell death Apoptosis Autophagy Stem cell Therapeutic strategies
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Quercetin Alleviates Lipopolysaccharide-Induced Cardiac Inflammation via Inhibiting Autophagy and Programmed Cell Death 认领 引用 被引量：2
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作者 YU Jin Hai HU Guo Liang +3 位作者 GUO Xiao Quan CAO Hua Bin XIA Zhao Fei AMIN Buhe 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第1期54-70,共17页
Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac dysfunction.Methods Specific pathogen-free chicken embryos(n=... Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac dysfunction.Methods Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(PBS)vehicle,PBS with ethanol vehicle,LPS(500 ng/egg),LPS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic cavity.At embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western blotting.Results They demonstrated that the heart presented inflammatory responses after LPS induction.The LPS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MYD88,NF-κB1,IFNγ,IL-1β,IL-8,IL-6,IL-10,p38,MMP3,and MMP9)were blocked by quercetin with three dosages.Quercetin significantly decreased immunopositivity to TLR4 and MMP9 in the treatment group when compared with the LPS group.Quercetin significantly decreased protein expressions of TLR4,IFNγ,MMP3,and MMP9 when compared with the LPS group.Quercetin treatment prevented LPS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LPS group.Quercetin significantly downregulated autophagyrelated gene expressions(PPARα,SGLT1,APOA4,AMPKα1,AMPKα2,ATG5,ATG7,Beclin-1,and LC3B)and programmed cell death(Fas,Bcl-2,CASP1,CASP12,CASP3,and RIPK1)after LPS induction.Quercetin significantly decreased immunopositivity to APOA4,AMPKα2,and LC3-II/LC3-I in the treatment group when compared with the LPS group.Quercetin significantly decreased protein expressions of AMPKα1,LC3-I,and LC3-II.Quercetin significantly decreased the protein expression to CASP1 and CASP3 by immunohistochemical investigation or Western blotting in treatment group when compared with LPS group.Conclusion Quercetin alleviates cardiac inflammation induced by LPS through modulating autophagy,programmed cell death,and myocardiocytes permeability. 展开更多
关键词 Quercetin Lipopolysaccharide Inflammation Autophagy Programmed cell death Myocardiocytes permeability
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An ARF1-binding factor triggering programmed cell death and periderm development in pear russet fruit skin 认领 引用 被引量：2
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作者 Yuezhi Wang Meisong Dai +4 位作者 Xinyi Wu Shujun Zhang Zebin Shi Danying Cai Lixiang Miao 《Horticulture Research》 SCIE CSCD 2022年第1期1024-1037,共14页
Plants have a cuticular membrane(CM)and periderm membrane(PM),which act as barriers to terrestrial stresses.The CM covers primary organs with a continuous hydrophobic layer of waxes embedded in cutin,while the PM incl... Plants have a cuticular membrane(CM)and periderm membrane(PM),which act as barriers to terrestrial stresses.The CM covers primary organs with a continuous hydrophobic layer of waxes embedded in cutin,while the PM includes suberized cells stacked externally to the secondary tissues.The formation of native periderm is regulated by a postembryonic meristem phellogen that produces suberized phellem(cork)outwardly.However,the mechanism controlling phellogen differentiation to phellem remains to be clarified.Here,map-based cloning in a pear F1 population with segregation for periderm development in fruit skin facilitated the identification of an aspartic acid repeat deletion in Pyrus Periderm Programmed Cell Death 1.1(PyPPCD1.1)that triggers phellogen activity for cork formation in russet fruit skin of pear.PyPPCD1.1 showed preferential expression in pear fruit skin,and the encoded protein shares a structural similarity to that of the viral capsid proteins.Aspartic acid deletion in PyPPCD1.1 weakened its nuclear localization but increased its accumulation in the chloroplast.The products of both PyPPCD1.1 and its recessive allele directly interact with ADP-ribosylation factor 1(ARF1).PyPPCD1.1 triggered programmed cell death in an ARF1-dependent manner.Thus,this study identified the switch gene for programmed cell death and periderm development and provided a new molecular regulatory mechanism underlying the development of this trait. 展开更多
关键词 primary organs postembryonic meristem phellogen secondary tissuesthe periderm membrane pm which suberized cells native periderm programmed cell death cuticular membrane cm
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