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Seismic design and performance of building structures with self-centering steel-concrete hybrid single-pier coupled walls 认领 引用
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作者 Mojtaba Farahi Fabio Freddi Massimo Latour 《Resilient Cities and Structures》 EI CSCD 2026年第1期85-101,共17页
In response to the demand for seismic-resilient structures,various innovative solutions have emerged to reduce local damage and residual deformations,facilitating repair operations in the aftermath of high-intensity e... In response to the demand for seismic-resilient structures,various innovative solutions have emerged to reduce local damage and residual deformations,facilitating repair operations in the aftermath of high-intensity earth-quakes.This paper examines the seismic performance of a steel-concrete hybrid wall system equipped with a selfcentering solution to mitigate earthquake-induced residual deformations.The considered hybrid system includes a Reinforced Concrete(RC)shear wall with two steel side columns connected by coupling steel beams.In this study,a novel type of coupling beams featuring a friction-damped self-centering system is implemented.The system is referred to as Self-Centering Hybrid Single-Pier Coupled Wall(SC-SP-HCW)and aims to minimize damage and residual deformations after earthquakes,which in turn facilitates repairs and enhances seismic resilience.Unlike conventional self-centering coupling beams with post-tensioned tendons,the self-centering configuration in this system does not rely on a gap-opening mechanism at the wall-beam connection interface,eliminating frame expansion effects.The proposed self-centering devices can also be implemented as preassembled links,which facilitates installation and reduces uncertainties associated with the on-site posttensioning procedure.The seismic performance of SC-SP-HCWs is investigated through nonlinear static and incremental dynamic analyses on case study SC-SP-HCWs designed as the lateral load-resisting systems of an eight-story building.The seismic response of the case study SC-SP-HCWs is investigated,considering both local and global engineering demand parameters(EDPs).The results demonstrate the ability of the SC-SP-HCWs to significantly reduce earthquake-induced residual deformations without exacerbating damage to structural ele-ments typically observed in conventional coupled walls. 展开更多
关键词 Hybrid coupled walls Damage-free self-centering links Friction devices Seismic performance Reinforced concrete walls
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Resilient self-centering viscous-based bracing with SMA and friction springs:Multi-objective control of displacement and acceleration-an analytical study 认领 引用
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作者 Navid Rahgozar M.Shahria Alam 《Resilient Cities and Structures》 EI CSCD 2026年第1期133-150,共18页
Self-Centering Piston-Based Braced Frames(SC-PBBFs)are designed to curtail structural damage under severe ground motions.The self-centering mechanism in this bracing mitigates structural damage during an earthquake,th... Self-Centering Piston-Based Braced Frames(SC-PBBFs)are designed to curtail structural damage under severe ground motions.The self-centering mechanism in this bracing mitigates structural damage during an earthquake,thereby reducing post-earthquake repair costs and contributing to seismic resilience.However,non-structural components,particularly those sensitive to floor acceleration,remain vulnerable,resulting in prolonged func-tional recovery times.This paper aims to address this limitation by introducing a novel structural archetype,the Self-Centering Viscous-Based Braced Frame(SC-VBBF),which integrates superelastic shape memory alloy(SMA)bars,viscous dampers(VDs),and friction springs(FSs).A streamlined analytical approach relies on the strength decoupling of VD from other components using aλfactor to design SC-VBBFs.To evaluate the effectiveness of the hybrid brace,a set of 4-,8-,and 12-story archetypes equipped with SC-PBBs and SC-VBBFs are simulated in OpenSees and analyzed under various earthquake types,including crustal,subcrustal,and subduction events.The results demonstrate the superior performance of the SC-VBBF withλ≤0.5 system compared to SC-PBBFs in mitigating floor accelerations under design-level earthquakes and improving seismic resilience. 展开更多
关键词 Self-centering Piston-based braced frame Self-centering viscous-based brace Shape memory alloy Viscous damper Friction spring Seismic analysis Design procedure Acceleration control
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Toward efficient multi-objective seismic design optimization of self-centering bridges using machine learning 认领 引用
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作者 Xueqi ZHONG Lintao TANG +1 位作者 Xiangnan LI Liuyang LI 《ENGINEERING Structure and Civil Engineering》 SCIE EI CAS CSCD 2026年第3期461-481,共21页
Self-centering rocking bridge piers,characterized by their minimal residual deformation and rapid postseismic recovery,have emerged as a promising solution for enhancing the seismic resilience of bridge systems.Howeve... Self-centering rocking bridge piers,characterized by their minimal residual deformation and rapid postseismic recovery,have emerged as a promising solution for enhancing the seismic resilience of bridge systems.However,their inherently nonlinear behavior and pronounced sensitivity to multiple interdependent design parameters make it challenging to achieve balanced seismic performance among all piers within an integrated bridge system.This work develops a system-oriented optimization framework for self-centering rocking bridges to address this issue.The proposed framework integrates machine learning-based surrogate modeling to markedly accelerate the optimization process.A detailed case study of a four-span self-centering rocking bridge is conducted to demonstrate the framework’s applicability and effectiveness.Results show that substituting traditional finite element model with an XGBoost-based surrogate model reduces computational time by 92%while preserving high predictive accuracy.Furthermore,the optimized design significantly enhances system-level performance uniformity,achieving a 52.3%reduction in inter-pier shear force variability and a 19.0%decrease in displacement disparity compared with the baseline configuration. 展开更多
关键词 self-centering rocking bridge machine learning seismic design multi-objective optimization nonlinear dynamics multi-criteria decision-making
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Sensitivity analysis of parameters influencing ED and self-centering capacity in self-centering bridge bents with ED beams using validated numerical model 认领 引用 被引量：1
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作者 XIE Wen BAO Yangyang +1 位作者 TIE Ning HONG Yangfan 《Journal of Southeast University(English Edition)》 EI CAS 2025年第3期338-347,共10页
A self-centering bridge bent equipped with energy-dissipation(ED)beams is proposed.Quasi-static tests are conducted on self-centering bridge bents,both with and without ED beams,to validate the accuracy of the corresp... A self-centering bridge bent equipped with energy-dissipation(ED)beams is proposed.Quasi-static tests are conducted on self-centering bridge bents,both with and without ED beams,to validate the accuracy of the corresponding numerical models.The effects of various param-eters,such as the web area of ED beams,prestressing force of tendons,tendon arrangements,and number of column segments,on the seismic performance of self-centering bridge bents with ED beams are evaluated using the validated numerical model.The results demonstrate that the nu-merical models accurately replicate the quasi-static test results,with average errors in the lateral force remaining below 9.6%.The web area of ED beams significantly affects the strength,cumulative energy dissipation,and relative self-centering index(RSI)of the self-centering bridge bents.Increasing the prestressing force enhances the lateral force and self-centering capability of the bridge bents but has minimal effect on their ED capacity.Reducing the num-ber of segments in each column enhances the lateral force and cumulative hysteretic energy dissipation of the self-centering bridge bents while exerting an insignificant effect on the RSI.Thus,the proposed novel system is highly suitable for doubleor multicolumn piers supporting bridges in regions prone to strong earthquakes. 展开更多
关键词 self-centering bridge bents energy-dissipation beams energy dissipation self-centering capacity quasi-static test numerical validation
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Influence of aerobic exercise on the cognitive and social functions of elderly patients with schizophrenia 认领 引用 被引量：1
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作者 Can Ao Lu Zhan +2 位作者 Yu-Lan Mou Shu Hu Yong-Hong Huang 《World Journal of Psychiatry》 SCIE 2026年第3期180-190,共11页
BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a nonin... BACKGROUND Schizophrenia presents complex challenges in older patients due to cognitive and social decline.Existing drug treatments offer limited benefits and pose risks,while aerobic exercise shows promise as a noninvasive intervention whose impact remains underexplored.AIM To investigate the effects of aerobic exercise on cognitive and social function in older patients with schizophrenia.METHODS A retrospective study was conducted in 158 older patients with schizophrenia treated at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(June 2023 and December 2024).The patients were divided into an observation group(n=86),which received 3 months of aerobic rehabilitation alongside routine treatment,and a control group(n=72),which received routine treatment alone.Cognitive function was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery,social function using the Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS),and psychotic symptoms using the Positive and Negative Syndrome Scale.RESULTS Post-treatment,Positive and Negative Syndrome Scale total scores were lower in the observation group than in the controls(P<0.001),with significant improvements in positive,negative,and general symptoms.Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery domain scores were improved in processing speed,working memory,verbal/visual learning,and executive function(all P<0.05).IPROS total scores were decreased(P<0.001),indicating better social functioning.Longer exercise duration correlated with greater cognitive gains and lower social function deficits.Body mass index declined(P<0.001),and adverse events were mild and transient(9.3%).Multivariate linear regression confirmed that aerobic exercise was independently associated with a significant reduction in IPROS scores(Adjustedβ=-4.57,95%confidence intervals:-6.08 to-3.05,P<0.001).CONCLUSION Aerobic exercise effectively improves cognitive function,social function,and psychotic symptoms in older patients with schizophrenia,is safe,and serves as a valuable adjunctive intervention. 展开更多
关键词 Schizophrenia Aerobic exercise Cognitive function Social function Elderly patients
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Supramolecular self-assembled graphitic carbon nitride catalyst:A comprehensive review on design principle,synthesis strategy,functionalization and application 认领 引用 被引量：2
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作者 Hao Yang Shaodong Sun +1 位作者 Qing Yang Jie Cui 《Nano Materials Science》 EI CAS CSCD 2026年第2期364-437,共74页
Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/... Graphitic carbon nitride(g-CN)stands out as the most promising candidate for solar energy conversion owing to its easy preparation,metal-free nature,flexible molecular structure,moderate bandgap,and excellent thermal/chemical stability.To enhance the performance of intrinsic g-CN,a supramolecular self-assembly strategy has been proposed to regulate the molecular structure of supramolecular precursors through non-covalent interactions across molecular building blocks,thereby optimizing the electronic structure of g-CN.This review provides a comprehensive overview of the recent progress in supramolecular self-assembly-derived graphitic carbon nitride(SM-CN)from both experimental and theoretical computational research in synthesis strategies,including synthesis methods and influencing factors,providing a theoretical foundation for the design of supramolecular assembly.It also discusses modification strategies,such as internal modification of the conjugated plane,interlayer optimization,and construction of heterointerfaces to improve the electronic structure of SM-CN owing to its unique layered structure.This review further summarizes the applications of SM-CN in environment and energy,including wastewater treatment,sterilization and disinfection/air purification,water splitting,H2O2production,organic synthesis/biomass conversion,CO2reduction,photocatalytic coupling technology.Finally,perspectives and outlooks for the future development of SM-CN aim to inspire further innovation in the design and construction of high-performance SM-CN for broader applications. 展开更多
关键词 Graphitic carbon nitride Photocatalysis Supramolecular self-assembly Functionalization Application
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Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function 认领 引用 被引量：1
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作者 Luyao Zhang Huan Tian +4 位作者 Yuanyuan Ma Jing Xu Chang Guo Zuomin Wang Jie Ma 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第1期115-125,共11页
Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microb... Chronic obstructive pulmonary disease(COPD),a disease responsible for early mortality worldwide,is well accepted to be associated with periodontitis epidemiologically.Although both of the diseases are the multi-microbial inflammatory disease,the precise underlying mechanisms by which periodontitis influences the progression of COPD remains largely unknown.Here,we established COPD accompanied with periodontitis mouse models and observed the pronounced progress in pulmonary symptoms and histopathology,cha racterized by poorer respiratory function,thicke ned bronchial walls,and increased neutrophils infiltration in lung tissue.Mechanistically,periodontitis pathogen Porphyromonas gingivalis(P.gingivalis)relocated in the lung through the respiratory tract and LPS from P.gingivalis promoted the secretion of chemokines CXCL2 and G-CSF of alveolar epithelial cells through NF-κB and p38 MAPK pathways to recruit neutrophils.Furthermore,exposure to P.gingivalis of infiltrated neutrophils released matrix metallopeptidase-8(MMP-8)and neutrophil elastase(NE),which aggravated airway inflammation and tissue damage.These findings indicated that periodontitis could exacerbate COPD via its pathogen P.gingivalis,which translocated in the lung and stimulated neutrophil chemotaxis and activation in the lung. 展开更多
关键词 neutrophils chemotaxis pulmonary symptoms histopathology periodontitis neutrophils function chronic obstructive pulmonary disease respiratory function chronic obstructive pulmonary disease copd
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Functional near-infrared spectroscopy:Systematic mapping of abnormal brain function features in neurological disorders 认领 引用 被引量：1
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作者 Yunjie Li Yangyang Feng +6 位作者 Xia Liu Ruochao Yuan Shiling Chen Jingyi Wang Chao Pan Gaigai Li Zhouping Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第10期4506-4522,共17页
Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight... Functional near-infrared spectroscopy quantifies cerebral hemodynamic signals by capturing oxygenation-dependent changes in hemoglobin in a noninvasive,portable,and ecologically valid manner,providing a unique insight into neurovascular coupling.However,functional imaging biomarkers with high ecological validity for neurological disorders such as stroke,Parkinson's disease,dementia,amyotrophic lateral sclerosis,epilepsy,spinal cord injury,and traumatic brain injury are lacking,limiting the mechanistic understanding,treatment evaluations,and individualized interventions.The aim of this review is to systematically summarize evidence from the past decade on the use of functional near-infrared spectroscopy under the aforementioned conditions,synthesize its value for revealing neural mechanisms and assessing therapeutic responses,and identify current technical bottlenecks and future directions for advancement.Collectively,the findings demonstrate that functional near-infrared spectroscopy possesses substantial and far-reaching potential for uncovering the neural mechanisms underlying disease and for evaluating treatment-induced changes in brain function.Equipped with wearable probes,functional near-infrared spectroscopy can continuously and noninvasively monitor brain activity in naturalistic environments for extended periods,thereby overcoming the limitations of conventional imaging modalities that can only acquire data under restricted settings.This capability can furnish unprecedented objective neuroimaging evidence for neuroregenerative therapy research.Moreover,the portability of functional near-infrared spectroscopy allows it to be integrated into neurofeedback training systems:hemoglobin signals can be fed back to participants within milliseconds,enabling targeted,individualized,closed-loop modulation of brain function and considerably expanding the scope of hemodynamicsbased neurofeedback.When combined with other brain function assays(such as electroencephalography)and intervention techniques(such as transcranial magnetic stimulation and transcranial direct current stimulation),functional near-infrared spectroscopy also supplies high-temporal-resolution hemodynamic information,laying a critical foundation for the construction of high-precision noninvasive brain–computer interfaces,real-time cognitivestate decoding,and adaptive neuromodulation.Admittedly,almost all existing functional near-infrared spectroscopy studies are still observational and have small sample sizes,short follow-ups,and insufficient controls—shortcomings that together produce low-grade evidence.Therefore,there is still a significant gap before clinical translation can be achieved.Technically,the limited penetration depth of functional near-infrared spectroscopy restricts sampling to the superficial cortex,leaving deep nuclei largely unreachable.In addition,no consensus exists across devices regarding optode layout,light-source choice,motion-artifact correction,or analytical pipelines,creating pronounced heterogeneity that undermines reproducibility.With artificial intelligence and big data analytics advancing rapidly,functional near-infrared spectroscopy embedded within multimodal fusion frameworks is now poised to systematically map aberrant brain function signatures of neurological disorders,identify pathological regions suitable for targeted intervention,and provide real-time assessments of functional changes produced by neuroregenerative therapies. 展开更多
关键词 biomarkers brain mapping clinical translational application functional connectivity functional near-infrared spectroscopy multimodal fusion nervous system diseases neuroimaging neuroregenerative therapy neurovascular coupling
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Synthetic metabolic engineering of functional crops:Boosting nutrition and human health 认领 引用 被引量：5
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作者 Nan Chai Jie Xu +12 位作者 Ruixiang Zhang Guangzhou Li Jun Wen Liying Su Yang Xue Tie Li Jialin Liu Dongchang Zeng Jiantao Tan Jiaqi Huang Letian Chen Yao-Guang Liu Qinlong Zhu 《The Crop Journal》 SCIE CSCD 2026年第1期8-21,共14页
A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synth... A growing global population and the increasing prevalence of diet-related health issues such as“hidden hunger”,obesity,hypertension,and diabetes necessitate a fundamental rethinking of crop design and breeding.Synthetic metabolic engineering offers a method to modify and redesign metabolic pathways to increase the nutritional value of crops.We summarize recent advances in the biofortification of key nutrients including provitamin A,vitamin C,vitamin B9,iron,zinc,anthocyanins,flavonoids,and unsaturated fatty acids.We discuss the potential of multi-gene stacking,gene editing,enzyme engineering,and artificial intelligence in synthetic metabolic engineering.We propose future research directions and potential solutions centered on leveraging AI-driven systems biology,precision gene editing,enzyme engineering,agrobacterium-mediated genotype-independent transformation,and modular metabolic engineering strategies to develop next-generation nutritionally enhanced super crops and transform global food systems. 展开更多
关键词 Synthetic biology Synthetic metabolism engineering Functional crops Multigene stacking and gene editing Artificial intelligence
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Ab initio density functional theory approach to warm dense hydrogen:From density response to electronic correlations 认领 引用 被引量：1
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作者 Zhandos A.Moldabekov Xuecheng Shao +5 位作者 Hannah M.Bellenbaum Cheng Ma Wenhui Mi Sebastian Schwalbe Jan Vorberger Tobias Dornheim 《Matter and Radiation at Extremes》 SCIE EI CAS CSCD 2026年第2期14-20,共7页
Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse ... Understanding the properties of warm dense hydrogen is of key importance for the modeling of compact astrophysical objects and to understand and further optimize inertial confinement fusion applications.The workhorse of warm dense matter theory is thermal density functional theory(DFT),which,however,suffers from two limitations:(i)its accuracy can depend on the utilized exchange-correlation functional,which has to be approximated,and(ii)it is generally limited to single-electron properties such as the density distribution.Here,we present a new ansatz combining time-dependent DFT results for the dynamic structure factor See(q,ω)with static DFT results for the density response.This allows us to estimate the electron-electron static structure factor See(q)of warm dense hydrogen with high accuracy over a broad range of densities and temperatures.In addition to its value for the study of warm dense matter,our work opens up new avenues for the future study of electronic correlations exclusively within the framework of DFT for a host of applications. 展开更多
关键词 thermal density functional theory dft whichhoweversuffers understanding properties warm dense hydrogen thermal density functional theory understand further optimize inertial confinement fusion applicationsthe warm dense matter theory electronic correlations warm dense hydrogen density functional theory
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Functional connectivity alterations in patients with poststroke cognitive impairment:A resting-state functional magnetic resonance imaging study 认领 引用 被引量：1
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作者 Yun-Yun Tao Ran Wang +2 位作者 Peng Zhang Xiao-Hua Huang Lin Yang 《World Journal of Radiology》 2026年第2期51-59,共9页
BACKGROUND Cognitive impairment is a common functional impairment after stroke that severely affects the quality of life of patients.The underlying neurobiological mechanisms of poststroke cognitive impairment(PSCI)re... BACKGROUND Cognitive impairment is a common functional impairment after stroke that severely affects the quality of life of patients.The underlying neurobiological mechanisms of poststroke cognitive impairment(PSCI)remain unclear.AIM To investigate the changes in functional connectivity(FC)in the brains of patients with PSCI.METHODS A total of 21 patients with PSCI and 12 healthy controls were selected as study subjects,and resting-state functional magnetic resonance imaging was performed.The brain region[Cerebellum_6_R(aal)]with significant differences identified by regional homogeneity analysis and the left thalamus,right thalamus,left basal ganglia,and right basal ganglia in the Brainnetome Atlas were selected as the seeds(regions of interest),and the FC between the seeds and whole-brain voxels was analyzed.Moreover,the 116 brain regions defined in the AAL116 atlas were selected as seeds(regions of interest),and the FC between the whole-brain seeds was calculated.RESULTS The results of the seed-based FC analysis revealed that the FC of the Cerebelum_9_R,Occipital_Mid_L,and Fusiform_R in the PSCI group was significantly greater than that in the control group.FC analysis of whole-brain seeds revealed that the FC of 20 pairs(Cerebelum_4_5_R and Cerebelum_6_R,etc.)in the PSCI group was significantly greater than that in the healthy control group.CONCLUSION Patients with PSCI exhibit changes in the FC of specific brain regions in the resting state,which may help researchers explore the underlying neurobiological mechanisms of PSCI from a new perspective. 展开更多
关键词 Functional connectivity Ischemic stroke Cognitive impairment Resting-state functional magnetic resonance imaging Stroke
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Research and development of a self-centering clamping device for deep-water multifunctional pipeline repair machinery 认领 引用 被引量：2
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作者 Wang Liquan Guo Shiqing +1 位作者 Gong Haixia Shang Xianchao 《Natural Gas Industry B》 2016年第1期82-89,共8页
When multifunctional pipeline repair machinery(MPRM)is used in the deep sea area,it is difficult to grip the pipeline and ensure concentricity between the cutter heads and the pipeline during its operation.In view of ... When multifunctional pipeline repair machinery(MPRM)is used in the deep sea area,it is difficult to grip the pipeline and ensure concentricity between the cutter heads and the pipeline during its operation.In view of this,a new system of two-arm holding self-centering pipeline clamping device was proposed.The system is composed of two groups of parallelogram double-rocker mechanism and cranking block mechanism which are symmetrically distributed on the frame.The geometric parameter solutions of the clamping device were analyzed with motion and transmission as the constraints.A mechanical model was established to associate the friction torque of clamping points with the driving force.Clamping device and machinery were designed and manufactured for theØ304.8e457.2 mm pipelines used in this test.ADAMS simulation experiments were conducted underwater,and the cutting and beveling tests were carried out onshore.The following results are achieved.First,the smaller the pipe diameter,the smaller the transmission angle of the oscillating slider mechanism;the longer the hydraulic cylinder stroke,the greater the transmission angle of the double rocker mechanism.Second,the driving force of the clamping device increases with the increase of the pipe diameter.When the diameter reaches 457.2 mm,the hydraulic cylinder driving force of the clamping device should be greater than 10219 N.Third,the feed rate of the cutters increases suddenly due to the slight shaking of the machinery which occurs at the beginning of the pipe cutting,so it is necessary to adopt a small feed rate.And fourth,onshore experiment results agree well with the theoretical design and simulation results,proving the rationality of the system.The research results in this paper provide technical basis for the research and development of similar engineering prototypes. 展开更多
关键词 Deepwater Submarine pipeline Multifunctional pipeline repair machinery Self-centering Two-arm holding Clamping device ADAMS simulation Experimental study Bevel
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New functional metal-organic framework(MOF) based optical thermometer by the post-synthesis doping rare earth ions into MOF 认领 引用 被引量：1
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作者 Ying Zhao Yin-Hang Chai +4 位作者 Meng-Meng Zhai Qin-Ying Jin Xiaoyan Lu Yi-Dan Qiao Lu-Fang Ma 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第1期644-649,共6页
Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the po... Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H4L) and Zn2+ ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K-1 was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K-1.In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties. 展开更多
关键词 MOFs Optical thermometer Post-synthesis functionalization Rare metal ions LED
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Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions 认领 引用 被引量：1
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作者 Xiuyu Fang Zihan Chi +6 位作者 Zhengyi Wang Xinlin Wang Xingrui Qu Shuang Zhang Feng Gao Baoming Shi Xuan Zhao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第1期404-425,共22页
Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementat... Background Weaning-induced diarrhoea and growth retardation in piglets are associated with impaired intestinal barrier function and decreased levels of colonic short-chain fatty acids(SCFAs).Although SCFA supplementation has been proposed to mitigate these issues,the efficacy and optimal dosage of sodium isobutyrate remain unclear.Results We investigated the effects of sodium isobutyrate supplementation(500,1,000,2,000,and 4,000 mg/kg diet)on weaned piglets(Duroc×Landrace×Yorkshire,28 d of age;n=8).After a 28-d feeding trial,supplementation at 500–2,000 mg/kg significantly improved average daily gain and feed efficiency and reduced diarrhoea frequency,with maximal benefits observed at 1,000 mg/kg(P<0.0001).Additionally,500–1,000 mg/kg sodium isobutyrate supplementation increased the apparent digestibility of crude protein,organic matter,and crude fibre(P<0.05).Serum biochemical parameters were unaffected,although secretory immunoglobulin A(SIgA)levels significantly increased upon supplementation with 500–1,000 mg/kg(P<0.05).16S rRNA gene sequencing indicated that sodium isobutyrate increased the abundance of beneficial colonic microbiota.The 1,000 mg/kg group presented the most pronounced effect,with a significant increase of the relative abundance of Prevotella and the greatest improvement in SCFA concentrations(P<0.05).Metabolomics revealed elevated levels of colonic indole-3-lactic acid and 3-hydroxybutyrate upon supplementation with 1,000 mg/kg(P<0.05).Transcriptomic analyses indicated activation of protein digestion and absorption pathways,and PI3K-Akt signalling,marked by TSG-6 upregulation and the suppression of ISG15 and DDIT4 expression(P<0.05).Supplementation with 1,000 mg/kg was associated with improved intestinal barrier-related markers,including reduced serum D-lactate,diamine oxidase,and lipopolysaccharide levels,increased tight junction protein expression;activation of G protein-coupled receptors;and inhibition of TLR4/MyD88/NF-κB signalling(P<0.05),suggesting enhanced barrier function.Conclusions In conclusion,dietary supplementation with 1,000 mg/kg sodium isobutyrate was associated with improved intestinal morphology,reduced serum permeability,increased expression of tight junction proteins,and enhanced immune function in weaned piglets,suggesting enhanced colonic barrier function and providing dosage guidance and mechanistic insights for future applications. 展开更多
关键词 Colonic barrier function Diarrhoea Intestinal microbiota Sodium isobutyrate Weaned piglets
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Definition of critical skin defect and concepts of structural and functional repairs:Proposal and verification in a rat model 认领 引用 被引量：1
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作者 Cong Sun Weihong Guo +4 位作者 Fang Liang Rabia Javed Weijian Hou Xingdong Zhang Qiang Ao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第1期168-182,共15页
Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult t... Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats. 展开更多
关键词 critical defect functional repair quantitative evaluation skin defect structural repair
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Performance-based comprehensive functional damage probability assessment framework for high-speed railway bridge under earthquake 认领 引用 被引量：1
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作者 Gaoyang Zhou Zhihui Zhu +1 位作者 Weiqi Zheng Yongjiu Tang 《Railway Engineering Science》 EI 2026年第2期201-216,共16页
Current seismic damage assessments for high-speed railway(HSR)bridges primarily focus on the overall structural safety,lacking evaluations from multiple performance perspectives,which affects the post-earthquake traff... Current seismic damage assessments for high-speed railway(HSR)bridges primarily focus on the overall structural safety,lacking evaluations from multiple performance perspectives,which affects the post-earthquake traffic decision-making for the bridges.This study proposes a performance-based comprehensive functional damage probability assessment framework for high-speed railway simply supported bridges(HSRSSBs)under earthquakes.The framework categorizes the functions of HSR bridges into three levels:post-earthquake traffic function(PTF),structural bearing function(SBF),and collapse resistance function(CRF),corresponding to the operational,structural safety,and structural integrity requirements of HSRSSB,respectively.By analyzing the damage states of key bridge components during earthquakes,the functional damage probability assessment indicators and classification thresholds are established according to various performance requirements.Damage probability calculations are conducted using the probability density evolution method and vulnerability method.Finally,based on the relationship between damage probabilities at different functional levels,a comprehensive damage probability assessment framework considering the three-level performance requirements of HSRSSBs is developed,and the influence of varying pier heights on the functional damage probability relationship is examined.The results indicate that current HSRSSB designs meet all performance requirements under frequent earthquakes.Under design-level earthquake conditions,the SBF remains in a slight damage state,while the PTF exhibits varying degrees of damage,which worsens as pier height increases.The pier structure satisfies seismic demands even under rare earthquake conditions. 展开更多
关键词 Earthquake High-speed railway bridge Damage probability Functional damage Performance-based
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury 认领 引用 被引量：3
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作者 Fanzhuo Zeng Yuxin Li +6 位作者 Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第1期365-376,共12页
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s... Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury. 展开更多
关键词 angiogenesis apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation microglia motor function spinal cord injury vascular endothelial growth factor
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Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes 认领 引用 被引量：4
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作者 Yu-Qi Shao Yong-Chen Wang +6 位作者 Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期800-810,共11页
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ... Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy. 展开更多
关键词 diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents neurodegeneration neuroprotection patch-clamp recording protein kinase C signaling pathway visual function
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A full information expression model for track irregularity based on stochastic harmonic functions in vehicle-turnout structure stochastic vibration analysis 认领 引用 被引量：1
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作者 Xueyang Tang Xiaopei Cai +1 位作者 Jingmang Xu Fei Yang 《Railway Engineering Science》 EI 2026年第2期349-369,共21页
Turnout irregularity significantly affects the stochastic vibration behavior of vehicle-turnout structures.This study proposes a fitting formula for the turnout irregularity spectrum and develops a turnout irregularit... Turnout irregularity significantly affects the stochastic vibration behavior of vehicle-turnout structures.This study proposes a fitting formula for the turnout irregularity spectrum and develops a turnout irregularity full information expression model(TIFIEM)using a stochastic harmonic function.The model is applied to vehicle-turnout structure stochastic vibration and reliability analysis.Findings suggest that the Hamming window method,with a window length of 4096 points,is optimal for estimating the turnout irregularity spectrum.It is recommended to fit the power spectral density(PSD)using a 5th-order polynomial for better accuracy.The TIFIEM effectively addresses randomness in amplitude,frequency,and phase.An analysis of 250 irregularity samples is sufficient for the desired accuracy.Additionally,the PSD amplitude at various frequency points follows a Chi-square distribution with 2°of freedom.Regions 3-7 m from the tip of the switch rail on the straight switch rail and 53-54 m on the point rail are most susceptible to wear.When the vehicle passes through the turnout at 300 km/h,the reliability of vehicle-turnout structures at the crossing panel decreases to 95.8%. 展开更多
关键词 High-speed railway Vehicle-turnout coupling dynamics Turnout irregularity spectrum Stochastic harmonic function Probability density evolution method
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Neuromodulation technologies improve functional recovery after brain injury:From bench to bedside 认领 引用 被引量：1
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作者 Mei Liu Yijing Meng +4 位作者 Siguang Ouyang Meng’ai Zhai Likun Yang Yang Yang Yuhai Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期506-520,共15页
Spontaneous recovery frequently proves maladaptive or insufficient because the plasticity of the injured adult mammalian central nervous system is limited.This limited plasticity serves as a primary barrier to functio... Spontaneous recovery frequently proves maladaptive or insufficient because the plasticity of the injured adult mammalian central nervous system is limited.This limited plasticity serves as a primary barrier to functional recovery after brain injury.Neuromodulation technologies represent one of the fastest-growing fields in medicine.These techniques utilize electricity,magnetism,sound,and light to restore or optimize brain functions by promoting reorganization or long-term changes that support functional recovery in patients with brain injury.Therefore,this review aims to provide a comprehensive overview of the effects and underlying mechanisms of neuromodulation technologies in supporting motor function recovery after brain injury.Many of these technologies are widely used in clinical practice and show significant improvements in motor function across various types of brain injury.However,studies report negative findings,potentially due to variations in stimulation protocols,differences in observation periods,and the severity of functional impairments among participants across different clinical trials.Additionally,we observed that different neuromodulation techniques share remarkably similar mechanisms,including promoting neuroplasticity,enhancing neurotrophic factor release,improving cerebral blood flow,suppressing neuroinflammation,and providing neuroprotection.Finally,considering the advantages and disadvantages of various neuromodulation techniques,we propose that future development should focus on closed-loop neural circuit stimulation,personalized treatment,interdisciplinary collaboration,and precision stimulation. 展开更多
关键词 functional recovery invasive electrical stimulation neuromodulation noninvasive electrical stimulation stroke transcranial magnetic stimulation transcranial photobiomodulation transcranial ultrasound stimulation traumatic brain injury
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