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Activation of Sirtuin 3,a Promising“Head Goose Molecule,”Triggers the Negentropic Mechanism for Treating Metabolic Diseases 认领 引用
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作者 Hu Li Tong Wang +2 位作者 Biao Dong Zonggen Peng Jiandong Jiang 《Engineering》 SCIE EI CSCD 2026年第5期294-309,共16页
Metabolic diseases,such as diabetes,obesity,and steatotic liver disease,represent a global epidemic.The pathogenesis of these disorders involves systemic disturbances in glucose homeostasis,lipid metabolism,energy bal... Metabolic diseases,such as diabetes,obesity,and steatotic liver disease,represent a global epidemic.The pathogenesis of these disorders involves systemic disturbances in glucose homeostasis,lipid metabolism,energy balance,and inflammation,yet effective therapeutic strategies to correct these core disturbances remain limited.Silent information regulator 3(sirtuin 3(SIRT3)),a major mitochondrial deacetylase that we defined as the"head goose molecule,"acts as a central regulator and can initiate a coordinated rescue of metabolic homeostasis.We integrate evidence that SIRT3 activation triggers a"negentropic mechanism,"a suite of processes that collectively counteract systemic metabolic disorders by enhancing insulin sensitivity,promoting lipid oxidation,fine-tuning redox equilibrium,optimizing energy expenditure,and suppressing inflammation.The therapeutic potential of SIRT3 activators derived from natural products,synthetic compounds,and nicotinamide adenine dinucleotide(NAD+)precursors is evaluated,highlighting their promise as safe and sustainable treatment options.This review establishes the role of SIRT3 as a master regulator and suggests that it should be targeted to reconstitute systemic metabolic homeostasis. 展开更多
关键词 Sirtuin 3 Metabolic diseases Head goose molecule Negentropic mechanism Sirtuin 3 activator
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Targeting sirtuins in diabetic retinopathy:Differential roles in inflammation and mitochondrial dysfunction 认领 引用
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作者 Chen-Chen Pan Qi-Qi Xie +7 位作者 Peng-Yu Lu Zhen Shi Hao-Yu Li Yu-Jie Ma Tian-Ye Ding Mei-Qi Zeng Cheng Luo Fu-Yuan Zhuge 《World Journal of Diabetes》 SCIE 2026年第4期71-91,共21页
Diabetic retinopathy(DR)is among the most prevalent microvascular complications of diabetes,with its onset and progression largely driven by chronic inflammation and mitochondrial dysfunction.In recent years,the nicot... Diabetic retinopathy(DR)is among the most prevalent microvascular complications of diabetes,with its onset and progression largely driven by chronic inflammation and mitochondrial dysfunction.In recent years,the nicotinamide adenine dinucleotide+dependent deacetylase family,sirtuins(SIRTs),has attracted growing attention for their integral roles in metabolic regulation,oxidative stress defense,inflammatory control,and cellular longevity.This review delineates the differential and stage-specific roles of SIRT isoforms in DR pathogenesis.SIRT1 attenuates inflammatory signaling by deacetylating key transcription factors,in-cluding nuclear factor-κB,and their target gene promoters,whereas the mitochon-dria-localized.SIRT3 directly deacetylates and activates antioxidant and metabolic enzymes to sustain reactive oxygen species balance and energy metabolism.Conversely,SIRT5 restores autophagic flux by desu-ccinylating optineurin at lysine-108,highlighting a novel link between post-translational modification and mitochondrial quality control.Accumulating preclinical evidence further indicates that various natural compounds and small-molecule activators,such as resveratrol,honokiol,and plant polyphenols,ameliorate DR-related pathology by upregulating SIRT signaling.By integrating current evidence,we highlight SIRTs as promising but complex therapeutic targets,underscoring the need for stage-specific intervention strategies and further research into less-explored isoforms to fully exploit their therapeutic potential. 展开更多
关键词 Diabetic retinopathy Inflammation Mitochondrial dysfunction Nuclear factor-κB NLR family pyrin domaincontaining 3 inflammasome Sirtuins Translational medicine
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Sirtuins家族调控骨骼肌萎缩作用机制的研究进展 认领 引用
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作者 刘炎铃 郑银 秦洁 《中华骨质疏松和骨矿盐疾病杂志》 CSCD 北大核心 2026年第1期109-116,共8页
骨骼肌萎缩是以肌纤维数量减少或结构破坏为核心病理特征的退行性病变,其中蛋白质合成和降解失衡及线粒体功能障碍与本病密切相关。近年其发病率呈持续上升趋势,严重影响患者生活质量。Sir-tuins家族是一组依赖于烟酰胺腺嘌呤二核苷酸... 骨骼肌萎缩是以肌纤维数量减少或结构破坏为核心病理特征的退行性病变,其中蛋白质合成和降解失衡及线粒体功能障碍与本病密切相关。近年其发病率呈持续上升趋势,严重影响患者生活质量。Sir-tuins家族是一组依赖于烟酰胺腺嘌呤二核苷酸活性的组蛋白脱乙酰酶,在调控细胞代谢、氧化应激、自噬、线粒体功能障碍等过程中发挥重要作用。研究表明该家族成员通过多种信号通路参与骨骼肌病理调控,是治疗骨骼肌萎缩的潜在靶点。本文就近年Sirtuins家族对骨骼肌萎缩的调控和其相关分子机制研究进展进行综述,旨在为骨骼肌萎缩研究领域及其防治策略提供新思路。 展开更多
关键词 Sirtuins家族 骨骼肌萎缩 防治
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Sirtuins家族在脂肪生成中的功能研究进展 认领 引用
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作者 崔金妍 徐虎 +2 位作者 张新 王园园 孙婴宁 《高师理科学刊》 2026年第1期91-96,共6页
Sirtuins是一类高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性去乙酰化酶,其家族7个成员(SIRT1~7)通过去乙酰化修饰等多种方式,在脂肪生成中具有核心调控作用。其中,SIRT1,SIRT2,SIRT5,SIRT6主要通过抑制关键成脂转录因子PPARγ的活性或... Sirtuins是一类高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性去乙酰化酶,其家族7个成员(SIRT1~7)通过去乙酰化修饰等多种方式,在脂肪生成中具有核心调控作用。其中,SIRT1,SIRT2,SIRT5,SIRT6主要通过抑制关键成脂转录因子PPARγ的活性或干扰其信号通路,负向调控脂肪生成;SIRT3,SIRT4,SIRT7则通过独特的分子机制促进脂肪沉积。综述了Sirtuins各成员在白色脂肪与棕色脂肪中的差异化功能及其分子机制,并探讨了以其为靶点干预肥胖、2型糖尿病等代谢性疾病的潜在前景,以期为相关领域的深入研究提供理论参考。 展开更多
关键词 Sirtuins家族 脂肪生成 2型糖尿病 乙酰化
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Farrerol and the miR-29b-3p/sirtuin 1 pathway:A mechanistic breakthrough in protecting the diabetic heart 认领 引用
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作者 Javier Donate-Correa Carlos E Martínez-Alberto 《World Journal of Diabetes》 SCIE 2026年第2期1-7,共7页
Diabetic cardiomyopathy(DCM)is a cardiac muscle disorder that causes heart failure independently of coronary artery disease.This condition remains a major clinical challenge,as current therapies primarily address trad... Diabetic cardiomyopathy(DCM)is a cardiac muscle disorder that causes heart failure independently of coronary artery disease.This condition remains a major clinical challenge,as current therapies primarily address traditional risk factors rather than the underlying molecular pathology.In this regard,endothelial dysfunction in the cardiac microvasculature is a key factor in DCM,linking metabolic alterations to impaired myocardial perfusion and fibrosis.Ferroptosis is a unique form of iron-dependent,regulated cell death characterized by lipid peroxidation.This mechanism has been linked to various diabetic complications,although its role in chronic diabetic heart disease remains unclear.In this editorial,we discuss new evidence highlighting endothelial cell ferroptosis as a key mechanism in DCM and a promising therapeutic target.Specifically,we discuss the recent study by Guo et al,demonstrating that farrerol,a natural flavonoid,improves DCM in mice by inhibiting endothelial ferroptosis through the microRNA-29b-3p/sirtuin 1 signaling axis.The findings of Guo et al reveal that downregulation of microRNA-29b-3p by farrerol is able to restore sirtuin 1 levels in cardiac endothelial cells,activating antioxidant defenses and preventing ferroptotic injury.Importantly,the endothelial protection generated by Farrerol translated into improvements in cardiac function and a reduction in fibrosis in diabetic mice.These results open a new therapeutic opportunity for the treatment of DCM by targeting the cardiac microvascular endothelium.Future studies should build on this mechanistic knowledge,addressing the challenges of converting Farrerol,a natural compound with antioxidant and antiferroptotic properties,or other ferroptosis inhibitors into targeted therapies that safely benefit patients with diabetic heart disease. 展开更多
关键词 Diabetic cardiomyopathy Endothelial dysfunction Ferroptosis MicroRNA-29b-3p Sirtuin 1 Farrerol
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Sirtuins家族在椎间盘退变中的研究进展 认领 引用
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作者 赵泽景 《临床医学进展》 2026年第2期1393-1401,共9页
椎间盘退变(IDD)是下腰痛的主要病理学基础,其核心特征包括髓核细胞功能失调、细胞外基质代谢失衡以及持续的炎症与氧化应激微环境。Sirtuins (SIRT)家族是一类依赖烟酰胺腺嘌呤二核苷酸的III类组蛋白去乙酰化酶,作为细胞能量代谢、应... 椎间盘退变(IDD)是下腰痛的主要病理学基础,其核心特征包括髓核细胞功能失调、细胞外基质代谢失衡以及持续的炎症与氧化应激微环境。Sirtuins (SIRT)家族是一类依赖烟酰胺腺嘌呤二核苷酸的III类组蛋白去乙酰化酶,作为细胞能量代谢、应激反应与衰老进程的核心感应与调控枢纽,在维持椎间盘稳态中扮演着关键角色。本综述系统阐述了SIRT家族在IDD中的多维度保护机制。SIRT通过去乙酰化修饰关键转录因子和信号蛋白,调控NF-κB等多条信号通路,从而抑制髓核细胞衰老与凋亡、维持ECM合成与降解的平衡、缓解氧化应激损伤、诱导保护性自噬并抑制炎症级联反应。基于这些机制,靶向激活SIRT通路展现出延缓IDD进程的治疗潜力。本文旨在梳理SIRT家族调控IDD的具体机制,并展望其作为疾病修饰治疗靶点的转化前景。 展开更多
关键词 Sirtuins 椎间盘退变 髓核细胞 细胞外基质 治疗靶点
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Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impairment through sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway 认领 引用 被引量：5
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作者 Wenqin Yang Wen Wen +4 位作者 Hao Chen Haijun Zhang Yun Lu Ping Wang Shijun Xu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第1期77-89,共13页
The activation of the sirtuin1(SIRT1)uclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing re... The activation of the sirtuin1(SIRT1)uclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS)levels.Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN)ameliorates post-stroke cognitive impairment(PSCI).However,the underlying mechanism,particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway,remains unclear.This study employed an oxygen-glucose deprivation(OGD)cell model using SHSY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory,neuroprotective activity,mitochondrial function,oxidative stress,and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro.Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)ratio,reduced terminal deoxynucleotidyl transferase-mediated d UTP nickend-labeling(TUNEL)+cells,and markedly improved cognition,synaptic plasticity,and neuronal function in the hippocampus and cortex.Furthermore,ZFXN exhibited potent antioxidant activity,evidenced by decreased ROS and malondialdehyde(MDA)content and increased superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)levels.ZFXN also demonstrated considerable enhancement of mitochondrial membrane potential(MMP),Tom 20 fluorescence intensity,adenosine triphosphate(ATP)and energy charge(EC)levels,and mitochondrial complexⅠandⅢactivity,thereby inhibiting mitochondrial damage.Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1,nuclear Nrf2,and HO-1 levels.Notably,these effects were substantially counteracted when SIRT1 was suppressed by the inhibitor EX-527 in vitro.In conclusion,ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochondrial damage. 展开更多
关键词 Zhongfeng Xingnao Liquid Post-stroke cognitive impairment Oxidative stress Mitochondrial function Apoptosis Sirtuin1uclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway
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Context-dependent role of sirtuin 2 in inflammation 认领 引用 被引量：2
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作者 NoemíSola-Sevilla Maider Garmendia-Berges +1 位作者 MCarmen Mera-Delgado Elena Puerta 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第3期682-694,共13页
Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has... Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases. 展开更多
关键词 interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2
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Sirtuin 3 Attenuates Acute Lung Injury by Decreasing Ferroptosis and Inflammation through Inhibiting Aerobic Glycolysis 认领 引用 被引量：1
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作者 Kewei Qin Qingqing Ji +7 位作者 Weijun Luo Wenqian Li Bingbing Hao Haiyan Zheng Chaofeng Han Jian Lou Liming Zhao Xingying He 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2025年第9期1161-1167,共7页
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is a severe clinical disorder characterized by widespread inflammation,diffuse alveolar damage,and pulmonary edema,often leading to respiratory failure a... Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is a severe clinical disorder characterized by widespread inflammation,diffuse alveolar damage,and pulmonary edema,often leading to respiratory failure and death.Despite significant advances in clinical care,ALI/ARDS remains the leading cause of death among intensive care unit patients.Sepsis is the primary risk factor for the development of ALI/ARDS,as excessive inflammatory responses contribute to organ injury and high mortality in critically ill patients. 展开更多
关键词 acute lung injury ali acute respiratory distress syndrome ards aerobic glycolysis severe clinical disorder intensive care ferroptosis inflammation sirtuin respiratory failure
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MRI-DWI参数ADC及血清Sirtuin1水平与AIS患者病情严重程度的相关性及其联合检测对患者预后不良的预测价值 认领 引用 被引量：1
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作者 冯亚芬 张俊丽 +1 位作者 邵山峰 张沙沙 《航空航天医学杂志》 2025年第9期1031-1034,共4页
目的分析磁共振弥散加权成像(MRI-DWI)参数表观弥散系数(ADC)、血清沉默信息调节蛋白1(Sirtuin1)水平与急性缺血性脑卒中(AIS)患者病情严重程度的相关性,及其联合检测对AIS患者预后不良的预测价值。方法选取2020年01月—2024年04月濮阳... 目的分析磁共振弥散加权成像(MRI-DWI)参数表观弥散系数(ADC)、血清沉默信息调节蛋白1(Sirtuin1)水平与急性缺血性脑卒中(AIS)患者病情严重程度的相关性,及其联合检测对AIS患者预后不良的预测价值。方法选取2020年01月—2024年04月濮阳市安阳地区医院收治的139例AIS患者,依据与美国国立卫生研究院卒中量表(NIHSS)评分标准,将AIS患者分为低分组(83例)、中分组(31例)、高分组(25例),比较三组MRI-DWI参数ADC、血清Sirtuin1水平,分析ADC、血清Sirtuin1水平与AIS患者病情严重程度的相关性。治疗后3个月,采用改良Rankin评分量表(mRS)评估AIS患者的预后情况,分为预后不良和预后良好亚组,比较预后不良和预后良好AIS患者的ADC、血清Sirtuin1水平,ROC曲线分析ADC、血清Sirtuin1水平联合检测对AIS患者预后不良的预测价值。结果三组间MRI-DWI参数ADC比较:低分组>中分组>高分组,血清Sirtuin1水平比较:低分组<中分组<高分组,两两比较,差异显著(P<0.05);Spearman相关性分析结果显示,ADC与AIS患者病情严重程度呈负相关(r=-0.679,P<0.05),血清Sirtuin1水平与病情严重程度呈正相关(r=0.653,P<0.05);预后不良患者ADC低于预后良好患者,血清Sirtuin1水平高于预后良好患者(P<0.05);ROC曲线结果显示,入院时MRI-DWI参数ADC、血清Sirtuin1水平联合检预测AIS患者预后不良的曲线下面积(AUC)为0.897,高于ADC、血清Sirtuin1水平单独检测的0.671、0.769(P<0.05)。结论入院时MRI-DWI参数ADC、血清Sirtuin1水平与AIS患者病情严重程度和临床预后具有相关性,且其联合检测对AIS患者预后不良具有较高的预测价值,可为临床评估AIS患者病情、预测患者预后提供有效参考。 展开更多
关键词 急性缺血性脑卒中 MRI-DWI参数 表观弥散系数 Sirtuin1 预后不良 预测价值
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Sirtuins蛋白在动脉粥样硬化中的研究进展 认领 引用 被引量：1
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作者 马江涛 曹又文 郑江华 《血管与腔内血管外科杂志》 2025年第8期1042-1046,共5页
Sirtuins(SIRT)蛋白家族包含SIRT7七个成员,能够在多种细胞代谢以及生理调节中发挥作用,例如基因稳定性调节,大多数氧化应激过程调节,细胞衰老、凋亡、增殖与代谢调节,器官寿命调节等。SIRT属于去乙酰化蛋白与腺苷二磷酸(ADP)核糖基转移... Sirtuins(SIRT)蛋白家族包含SIRT7七个成员,能够在多种细胞代谢以及生理调节中发挥作用,例如基因稳定性调节,大多数氧化应激过程调节,细胞衰老、凋亡、增殖与代谢调节,器官寿命调节等。SIRT属于去乙酰化蛋白与腺苷二磷酸(ADP)核糖基转移酶,SIRT蛋白活性主要受细胞里面烟酰胺腺嘌呤二核苷酸(NAD~+)调节。SIRT1、SIRT3、SIRT6、SIRT7均与动脉粥样硬化(AS)发生、发展密切相关。本文就SIRT1、SIRT3、SIRT6、SIRT7在AS发生发展中的改善内皮细胞功能、控制炎症、控制氧化应激、调节细胞自噬、抑制泡沫细胞生成等相关研究进展进行综述,以期为临床更好地了解AS发病机制,寻找新的AS防治方法提供参考。 展开更多
关键词 动脉粥样硬化 Sirtuins蛋白 研究进展
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Sirtuins蛋白家族在肿瘤中的作用:一种潜在的药物治疗新靶点 认领 引用
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作者 赵雨诗 王佰川 +1 位作者 韩勇 王婷 《医药导报》 CAS 北大核心 2025年第10期1655-1660,共6页
Sirtuins蛋白家族是一类高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性蛋白去乙酰化酶,在哺乳动物中有7种亚型,每种亚型具有不同的亚细胞定位和生物学功能,在代谢重编程的调节和细胞死亡的调节以及肿瘤表型的形成中起关键作用。因此,调... Sirtuins蛋白家族是一类高度保守的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性蛋白去乙酰化酶,在哺乳动物中有7种亚型,每种亚型具有不同的亚细胞定位和生物学功能,在代谢重编程的调节和细胞死亡的调节以及肿瘤表型的形成中起关键作用。因此,调节去乙酰化酶活性被认为是病理学的一种有前途的治疗选择。该文聚焦于阐述Sirtuins蛋白在肿瘤中作用和分子机制,以及Sirtuins激活剂和抑制剂在肿瘤中应用,指导相关恶性肿瘤的靶向治疗和药物开发。 展开更多
关键词 Sirtuins蛋白家族 癌基因 抑癌基因 靶点
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Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment 认领 引用
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作者 Hao-Yu Zhao Chu-Ying Yu +3 位作者 Xin-Tong Ye Su-Ting Qian Ye Huang Qing-Sheng Liu 《World Journal of Clinical Oncology》 2025年第12期79-89,共11页
Sirtuin 3(SIRT3)is a primary mitochondrial deacetylase.Studies have confirmed that it directly activates mitophagy by modulating mitochondrial protein acetylation.As a key homeostatic mechanism,mitophagy activation al... Sirtuin 3(SIRT3)is a primary mitochondrial deacetylase.Studies have confirmed that it directly activates mitophagy by modulating mitochondrial protein acetylation.As a key homeostatic mechanism,mitophagy activation alleviates oxidative stress-induced imbalance between cell proliferation and apoptosis,corrects stress-driven mitochondrial metabolic dysfunction,and thus inhibits excessive tumor growth,exerting significant antitumor effects.These functions establish SIRT3 as a key target for regulating mitophagy and cancer therapy.Clinically,strategies centered on its precise regulation may offer a novel direction for gastric cancer(GC)prevention and treatment,with selective activation remaining a critical challenge.SIRT3 could also serve as an auxiliary indicator in clinical guidelines for assessing tumor progression.Given this potential,this minireview systematically examines SIRT3’s mechanisms in regulating mitophagy,its role in GC pathogenesis,and translational prospects for targeting SIRT3 in GC management. 展开更多
关键词 Sirtuin 3 Gastric cancer Mitochondrial function Mitophagy Oxidative stress Antitumor
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Sirtuins蛋白家族在慢性肾脏病血管钙化中的研究进展 认领 引用
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作者 钱传丽 薛泽湖 +2 位作者 刘曦 刘其锋 郁丽霞 《中国医药导报》 CAS 2025年第34期174-178,196,共5页
血管钙化(VC)是慢性肾脏病的常见并发症之一,具有发病机制复杂、治疗手段局限等特点,严重影响患者预后。因此,寻找治疗VC的新靶点刻不容缓。Sirtuins蛋白是一种长寿蛋白,参与调控细胞氧化应激、去乙酰化、谷氨酰胺代谢、激活自噬等多种... 血管钙化(VC)是慢性肾脏病的常见并发症之一,具有发病机制复杂、治疗手段局限等特点,严重影响患者预后。因此,寻找治疗VC的新靶点刻不容缓。Sirtuins蛋白是一种长寿蛋白,参与调控细胞氧化应激、去乙酰化、谷氨酰胺代谢、激活自噬等多种生理过程。随着Sirtuins蛋白家族抗VC的作用逐渐被发现,其与VC的关系成为研究热点。本文综述Sirtuins蛋白家族对VC的影响及作用机制,旨在厘清Sirtuins蛋白家族与VC的关系,探寻潜在治疗VC的新靶点。 展开更多
关键词 Sirtuins蛋白家族 慢性肾脏病 血管钙化
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Targeting sirtuin 1/nuclear factor erythroid 2-related factor 2/tumor necrosis factor-αpathway to modulate hepatic ischemia reperfusioninduced injury 认领 引用
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作者 Mina Thabet Kelleni Walaa Yehia Abdelzaher +3 位作者 Marly Adly Mina Ezzat Attya Michael A Fawzy Mohamed Abdellah Ibrahim 《World Journal of Hepatology》 2025年第12期184-195,共12页
BACKGROUND Hepatic ischemia reperfusion(HIR)injury is a major complication affecting various major liver surgeries,including liver transplantation.Aprepitant(APRE),a neurokinin-1 receptor antagonist,is commonly used a... BACKGROUND Hepatic ischemia reperfusion(HIR)injury is a major complication affecting various major liver surgeries,including liver transplantation.Aprepitant(APRE),a neurokinin-1 receptor antagonist,is commonly used as an antiemetic to prevent chemotherapy-induced nausea and vomiting.AIM To assess the potential protective effect of APRE against HIR-induced liver injury via targeting the nucleotide-binding oligomerization domain-,leucine-rich repeat-,and pyrin domain-containing receptor 3/interleukin(IL)-1beta signaling pathway.METHODS Six groups of adult male Wistar albino rats were divided as follows:Sham group,Sham/APRE10 group(APRE 10 mg/kg),HIR group,HIR/APRE5 group(APRE 5 mg/kg),HIR/APRE10 group(APRE 10 mg/kg),and HIR/APRE20 group(APRE 20 mg/kg).Serum alanine transaminase,aspartate transaminase,liver malondialdehyde,total antioxidant capacity levels,as well as IL-6,sirtuin 1(Sirt1),caspase-3,cleaved caspase-3,and tumor necrosis factor alpha biomarkers,were evaluated.Hepatic specimens were examined histopathologically and immunohistochemically for nuclear factor erythroid-2-related factor 2(Nrf2)immunoexpression.RESULTS HIR resulted in hepatic damage,as evidenced by histopathological changes and a significant increase in serum alanine transaminase,aspartate transaminase,hepatic malondialdehyde,caspase-3,and tumor necrosis factor alpha levels.Additionally,there were significant increases in hepatic total antioxidant capacity and reductions in IL-6 and cleaved caspase-3 protein levels,as demonstrated by Western blot analysis,along with enhanced immunoexpression of Sirt1 and Nrf2.APRE has significantly reduced various parameters of oxidative stress,inflammation,and apoptosis,and a significant increase in liver Nrf2 immunoexpression,leading to a significant improvement in the histopathological changes.CONCLUSION In conclusion,targeting the Sirt1/Nrf2 signaling pathway,as demonstrated by APRE in our model,could present a promising therapeutic target to protect against HIR-induced liver injury during major liver surgeries. 展开更多
关键词 Hepatic ischemia reperfusion injury Aprepitant Sirtuin 1 Nuclear factor erythroid-2-related factor 2 Tumor necrosis factor alpha
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Sirtuins蛋白家族在胃癌中的研究现状 认领 引用
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作者 卢姿 张文波 +1 位作者 蒋鹏程 陈志红 《医学研究与战创伤救治》 北大核心 2025年第6期651-656,共6页
Sirtuins蛋白家族是一类依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的组蛋白去乙酰化酶,其主要通过调控基因转录或催化去乙酰化、去琥珀酰化、ADP-核糖基转移等反应调节蛋白活性和功能,从而参与调控细胞代谢、炎症反应、氧化应激、细胞自噬... Sirtuins蛋白家族是一类依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的组蛋白去乙酰化酶,其主要通过调控基因转录或催化去乙酰化、去琥珀酰化、ADP-核糖基转移等反应调节蛋白活性和功能,从而参与调控细胞代谢、炎症反应、氧化应激、细胞自噬及凋亡等生理过程。Sirtuins蛋白家族不同成员在亚细胞定位和功能方面显示出多样性。随着研究的深入,日益增多的证据揭示了Sirtuins蛋白家族在胃癌发生与发展过程中扮演了复杂的双向调控角色。文章就Sirtuins蛋白家族的发展历程、分子机制及其在胃癌中的作用进行综述。 展开更多
关键词 胃癌 Sirtuins蛋白家族 发病机制
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Sirtuins在衰老相关口腔疾病中的研究进展 认领 引用
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作者 刘宇村曦 吴明松 刘建国 《遵义医科大学学报》 2025年第4期400-407,413,共8页
衰老是指机体生理和心理功能随增龄呈渐进性衰退、逐渐趋向死亡的现象。沉默信息调节因子(sirtuins)家族是一类高度保守地依赖于NAD+的组蛋白去乙酰化酶,参与许多与衰老相关的生物学过程,调节许多与衰老相关的信号通路。随着年龄的增... 衰老是指机体生理和心理功能随增龄呈渐进性衰退、逐渐趋向死亡的现象。沉默信息调节因子(sirtuins)家族是一类高度保守地依赖于NAD+的组蛋白去乙酰化酶,参与许多与衰老相关的生物学过程,调节许多与衰老相关的信号通路。随着年龄的增长,牙周炎、口腔癌和根尖周病等口腔疾病的患病率增加,Sirtuins在该过程中起重要的调控作用。本文就Sirtuins家族的一般情况,Sirtuins与衰老相关的重要信号通路和Sirtuins在衰老相关的口腔疾病中的调控作用进展作一综述。 展开更多
关键词 sirtuins 衰老 信号通路 牙周炎 口腔癌 根尖周病
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线粒体Sirtuins在疾病中的作用及天然激活剂的研究进展 认领 引用 被引量：3
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作者 杨艳敏 张克交 +1 位作者 张彦栋 庄馨瑛 《中医临床研究》 2020年第30期132-135,共4页
哺乳动物中Sirtuin蛋白家族已知的亚型有7种,即Sirt1-7。Sirtuin蛋白主要通过调节细胞内的乙酰化修饰水平发挥调控作用,同时Sirtuin蛋白有不同的亚细胞定位,定位于线粒体的是Sirt3、Sirt4和Sirt5。Sirtuin蛋白参与了线粒体的许多关键生... 哺乳动物中Sirtuin蛋白家族已知的亚型有7种,即Sirt1-7。Sirtuin蛋白主要通过调节细胞内的乙酰化修饰水平发挥调控作用,同时Sirtuin蛋白有不同的亚细胞定位,定位于线粒体的是Sirt3、Sirt4和Sirt5。Sirtuin蛋白参与了线粒体的许多关键生理过程,如调节新陈代谢和应激反应,参与卡路里限制的益寿作用等,因此也在代谢性疾病、神经退行性疾病、肿瘤等多种疾病中发挥作用。本文对线粒体定位的Sirtuin蛋白的功能和它们在疾病中的作用进行了回顾并总结了天然产物中存在的Sirtuin蛋白激活剂,为相关疾病的药物开发提供理论支持。 展开更多
关键词 Sirtuin蛋白 Sirt3 Sirt4 Sirt5 Sirtuin激活剂
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慢性牙周炎合并2型糖尿病患者龈沟液Sirtuin-1、Sirtuin-6的变化及临床价值研究 认领 引用 被引量：6
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作者 杨淇 郑卫卫 +2 位作者 于洁 马丽华 郭俊峰 《现代生物医学进展》 CAS 2024年第3期486-491,共6页
目的:探讨慢性牙周炎(CP)合并2型糖尿病(T2DM)患者龈沟液沉默信息调节因子-1(Sirtuin-1)、Sirtuin-6的变化和临床价值。方法:选择2020年3月至2023年3月中国人民解放军联勤保障部队第九七〇医院收治的147例CP合并T2DM患者(T2DM组),128例... 目的:探讨慢性牙周炎(CP)合并2型糖尿病(T2DM)患者龈沟液沉默信息调节因子-1(Sirtuin-1)、Sirtuin-6的变化和临床价值。方法:选择2020年3月至2023年3月中国人民解放军联勤保障部队第九七〇医院收治的147例CP合并T2DM患者(T2DM组),128例单纯CP患者(CP组)和121例健康体检者(对照组)。根据牙周检查结果将T2DM组患者分为轻度组(n=49)、中度组(n=67)、重度组(n=31)。检测受试者龈沟液中Sirtuin-1、Sirtuin-6水平以及外周血单核细胞核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3(NLRP3)信使核糖核酸(mRNA)、程序性细胞死亡相关斑点样蛋白(ASC)mRNA、半胱氨酸蛋白酶1(Caspase-1)mRNA表达,并评估牙周临床指标。Pearson分析CP合并T2DM患者龈沟液Sirtuin-1、Sirtuin-6水平与牙周临床指标、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达的相关性。受试者工作特征(ROC)曲线分析龈沟液Sirtuin-1、Sirtuin-6诊断CP合并T2DM的价值。结果:T2DM组龈沟液Sirtuin-1、Sirtuin-6水平低于CP组和对照组(P<0.05),出血指数(SBI)、牙周袋探诊深度(PD)、牙龈指数(GI)、菌斑指数(PLI)、附着丧失(AL)、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达高于CP组和对照组(P<0.05)。CP组龈沟液Sirtuin-1、Sirtuin-6水平低于和对照组(P<0.05),GI、SBI、PLI、PD、AL、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达高于对照组(P<0.05)。重度组龈沟液Sirtuin-1、Sirtuin-6水平低于中度组和轻度组(P<0.05),GI、PLI、SBI、AL、PD、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达高于中度组和轻度组(P<0.05)。中度组龈沟液Sirtuin-1、Sirtuin-6水平低于轻度组(P<0.05),GI、PLI、SBI、AL、PD、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达高于轻度组(P<0.05)。CP合并T2DM患者龈沟液Sirtuin-1、Sirtuin-6水平与GI、PLI、SBI、AL、PD、外周血单核细胞NLRP3 mRNA、ASC mRNA、Caspase-1 mRNA表达均呈负相关(P<0.05)。龈沟液Sirtuin-1、Sirtuin-6诊断CP合并T2DM的曲线下面积(AUC)为0.787、0.806,联合诊断AUC为0.912,高于单独诊断。结论:CP合并T2DM患者龈沟液中Sirtuin-1、Sirtuin-6水平降低,且与牙周组织破坏程度加重、NLRP3炎症小体激活有关。龈沟液Sirtuin-1联合Sirtuin-6在CP合并T2DM诊断中具有较高价值。 展开更多
关键词 慢性牙周炎 2型糖尿病 Sirtuin-1 Sirtuin-6 NLRP3炎症小体 临床价值
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Role of sirtuins in ischemia-reperfusion injury 认领 引用 被引量：16
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作者 Eirini Pantazi Mohamed Amine Zaouali +3 位作者 Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Joan Roselló-Catafau 《World Journal of Gastroenterology》 SCIE CAS 2013年第43期7594-7602,共9页
Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation.Several factors contribute to its complexity;the depletion of energy... Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation.Several factors contribute to its complexity;the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury.Recently,the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers,due to their involvement in the modulation of a wide variety of cellular functions.There are seven mammalian sirtuins and,among them,the nuclear/cytoplasmic sirtuin 1(SIRT1)and the mitochondrial sirtuin 3(SIRT3)are ubiquitously expressed in many tissue types.Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways,which are key processes during IRI.In this review,we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress,apoptosis,microcirculatory stress and inflammation during reperfusion.We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action. 展开更多
关键词 Sirtuin 1 Sirtuin 3 Ischemia-reperfusion injury oxidative stress Apoptosis
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