The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture majo...The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture major.The"integration of general and specialized education"is the key path to solve the problems of"prominent disciplinary barriers,fragmented knowledge structure,and weak practical ability"in the traditional curriculum system.In this paper,the College of Smart Agriculture from Yulin Normal University is taken as the research object.Based on the characteristics of regional agricultural industry and the positioning of professional education,the prominent problems in the current professional curriculum system of smart agriculture are analyzed,the construction concept of"strong foundation in general education,precise core in professional education,and breaking through boundaries in integrated education"is proposed,and a"three dimensions and four layers"integrated curriculum system framework for general and specialized education is constructed.Moreover,practical exploration is conducted from the aspects of curriculum module design,teaching mode innovation,and guarantee mechanism construction.Practice has shown that this curriculum system effectively enhances students'interdisciplinary application abilities and industry adaptability,and provides a practical sample for the reform of smart agriculture courses in local universities under the background of new agricultural science.展开更多
Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial t...Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial to build a faculty team with knowledge in industry application fields and experience in domestic software development.This paper first analyzes the new requirements for the faculty imposed by the cultivation of specialized software talents and the existing problems in the current faculty.Then,in response to these issues,it introduces the reforms and explorations carried out by the School of Software Engineering at Beijing Jiaotong University in the construction of the faculty for cultivating specialized software talents.The aim is to build a high-caliber and diversified faculty that boasts strong political qualities,interdisciplinary integration,complementary advantages between full-time and part-time faculty,and in-depth integration of industry and education.展开更多
Objective:To compare the application effects of routine care and routine care combined with specialized respiratory tract care in patients after cardiothoracic surgery.Methods:This study involved 102 patients who unde...Objective:To compare the application effects of routine care and routine care combined with specialized respiratory tract care in patients after cardiothoracic surgery.Methods:This study involved 102 patients who underwent cardiothoracic surgery in our hospital from September 2024 to December 2025.They were randomly divided into a control group(51 cases)and an observation group(51 cases).The control group received routine postoperative care for cardiothoracic surgery,while the observation group received specialized respiratory tract care in addition to routine care.The postoperative recovery,effective expectoration rate,and incidence of postoperative pulmonary complications were compared between the two groups.Results:The observation group had shorter ICU stays,drainage tube indwelling times,and hospital stays than the control group,with p<0.05.The effective expectoration rate in the observation group was higher than that in the control group,with p<0.05.The total incidence of postoperative pulmonary complications in the observation group was lower than that in the control group,with p<0.05.Conclusion:Adding specialized respiratory tract care to routine postoperative care in cardiothoracic surgery can effectively improve the effective expectoration rate,reduce the incidence of pulmonary complications,and promote postoperative recovery in patients.展开更多
Within contemporary healthcare systems, professional identity among specialized nurses serves as a pivotal intrinsic factor influencing the development of their core competencies. This review synthesizes existing rese...Within contemporary healthcare systems, professional identity among specialized nurses serves as a pivotal intrinsic factor influencing the development of their core competencies. This review synthesizes existing research, revealing that professional identity positively impacts the development of core competencies through multiple pathways, including psychological drive, behavioral facilitation, teamwork, and career stability. Building on this analysis, this paper proposes systematic enhancement strategies from four dimensions: education and training, organizational environment, cultural development, and individual growth, aiming to provide a reference for nursing practice and professional development.展开更多
Objective:This paper focuses on a comprehensive analysis of the overall framework and core operational points of specialized,systematic nursing interventions for children with brain abscesses undergoing complete antim...Objective:This paper focuses on a comprehensive analysis of the overall framework and core operational points of specialized,systematic nursing interventions for children with brain abscesses undergoing complete antimicrobial therapy,and explores the practical effects of such structured nursing models on enhancing treatment compliance,preventing related complications,and improving long-term neurological recovery.Methods:A cohort analysis model incorporating both retrospective and prospective features was designed.The study subjects were identified as 76 pediatric patients admitted from early 2020 to the end of 2023,diagnosed with brain abscesses,and who completed the prescribed anti-infective treatment course.Based on different clinical nursing pathways adopted,all cases were equally divided into two groups:a control group receiving standard routine care(38 cases)and a practice group applying a specialized integrated nursing protocol designed for this study(38 cases).This specialized protocol systematically integrates four dimensions:precise monitoring of intracranial pressure changes,a full-process management strategy for antimicrobial drug use,neurological function maintenance measures,and a family-centered educational support plan.The study comprehensively recorded various clinical observation indicators for both groups during treatment.Results:Data analysis revealed that the practice group adopting the specialized nursing protocol demonstrated superiority across multiple evaluation indicators.The effective symptom control rate during treatment(94.7%vs.78.9%,p<0.05),the incidence of adverse events induced by treatment drugs(10.5%vs.28.9%,p<0.05),and the qualification rate of primary caregivers of the children in mastering relevant knowledge and skills(92.1%vs.71.1%,p<0.05)were all significantly better than those in the routine care group.Additionally,the practice group showed statistically significant reductions in time-sensitive indicators such as the average number of days required for fever resolution,the time for relief of meningeal irritation signs,and the overall length of hospital stay(all comparisons p<0.05).In the follow-up Glasgow Outcome Scale scores conducted three months after treatment completion,the proportion of cases in the practice group achieving a good prognosis(scores of 4 to 5)reached 86.8%,significantly higher than the 68.4%in the control group(p<0.05).Conclusion:A multi-component,interlinked specialized nursing practice developed around and deeply integrated with the anti-infective treatment mainline can clearly enhance the safety level and overall efficiency of clinical management for pediatric brain abscesses.展开更多
In the deep-water zone of the global digital economy in 2026,the survival rules for“Specialized,Refined,and Innovative”SMEs are undergoing a fundamental shift.Artificial Intelligence(AI)has evolved from an efficienc...In the deep-water zone of the global digital economy in 2026,the survival rules for“Specialized,Refined,and Innovative”SMEs are undergoing a fundamental shift.Artificial Intelligence(AI)has evolved from an efficiency tool into a“digital foundation”that anchors corporate positions amidst uncertainty.This paper examines the new commercial paradigm of“digital resilience”through empirical research on 312 representative enterprises in the Greater Bay Area and case studies of hard-tech leaders in Beijing.Findings indicate that AI adoption significantly enhances a firm’s ability to perceive and recover from supply chain shocks.The study concludes that the integration of industry deep-plowing and AI investment creates an asymmetric competitive advantage,forming a“flexible moat”for sustainable growth.展开更多
Stereotactic multi-target precise transplantation of stem cells into the brain is an innovative neural repair approach that integrates minimally invasive neurosurgery and regenerative medicine.Under precise image guid...Stereotactic multi-target precise transplantation of stem cells into the brain is an innovative neural repair approach that integrates minimally invasive neurosurgery and regenerative medicine.Under precise image guidance,stem cells can be delivered accurately into ischemic-injured areas and functional nuclei,thereby promoting neural circuit reconstruction and neurological function recovery.With the clinical transformation of this technique,establishing a systematic,standardized,and specialized nursing system is crucial to ensure surgical safety,reduce intracranial complications,improve therapeutic effect,and accelerate neurological recovery.Based on the technical characteristics,repair mechanisms and pathophysiological features of ischemic brain injury,this study constructed a comprehensive specialized nursing system including perioperative management,intraoperative cooperation,complication monitoring,immune rejection control,rehabilitation training,psychological intervention and continuous follow-up,so as to provide a reliable reference for clinical nursing practice.展开更多
BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive sym...BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive symptoms in postmenopausal women with osteoporosis and develop targeted psychological nursing interven-tions.METHODS A total of 180 postmenopausal women with osteoporosis admitted to the Depar-tment of Orthopedics at the First Affiliated Hospital of Soochow University between October 2021 and October 2024 were selected as research participants.Information on age,duration of menopause,body mass index,education level,marital status,activity intensity,bone density,presence of chronic diseases,calcium supplement intake,sex hormone levels,and depressive symptoms were collected.The 24-item Hamilton Depression Scale was used for assessment.RESULTS Forty-eight patients had no depressive symptoms,and 132 patients had depre-ssive symptoms.Comprehensive univariate and multivariate logistic regression analyses showed that low bone density in the lumbar spine(L2-L4)and femoral neck,presence of chronic diseases,and low 5-hydroxytryptamine levels were independent risk factors for depressive symptoms,whereas calcium supplement intake and moderate to high-intensity activity were independent protective factors.CONCLUSION By implementing specialized psychological nursing interventions,and providing rehabilitation guidance,the incidence of depressive symptoms can be effectively reduced,improving the psychological health status and patient quality of life.展开更多
Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received...Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received treatment at our hospital from May 2022 to December 2024 were selected as study subjects.The patients were randomly divided into a control group and an observation group,with 94 patients in each group.The control group received routine nursing intervention,while the observation group received specialized nursing intervention.The general information,swallowing function,quality of life,and nursing satisfaction were compared between the two groups.Results:There was no statistically significant difference in general information between the two groups(P>0.05).The SAS score of the observation group after nursing was significantly lower than that of the control group(t=19.463,P=0.000<0.001).After intervention,the number of patients with lung infection in the observation group was significantly lower than that in the control group(χ2=7.309,P=0.007<0.01).The overall quality of life score of the observation group was significantly better than that of the control group after intervention(P<0.001).The nursing satisfaction of the observation group was significantly higher than that of the control group(χ2=15.865,P=0.000<0.001).Conclusion:Compared with routine care,specialized nursing intervention can effectively improve the swallowing function of patients with dysphagia during acute stroke,enhance their quality of life,and increase nursing satisfaction.展开更多
With the intensifying competition in the integrated circuit(IC)industry,the high turnover rate of integrated circuit engineers has become a prominent issue affecting the technological continuity of high-precision,spec...With the intensifying competition in the integrated circuit(IC)industry,the high turnover rate of integrated circuit engineers has become a prominent issue affecting the technological continuity of high-precision,specialized,and innovative enterprises.As a representative of such enterprises,JL Technology has faced challenges to its R&D efficiency due to talent loss in recent years.This study takes this enterprise as a case to explore feasible paths to reduce turnover rates through optimizing training and career development systems.The research designs a method combining learning maps and talent maps,utilizes a competency model to clarify the direction for engineers’skill improvement,implements talent classification management using a nine-grid model,and achieves personalized training through Individual Development Plans(IDPs).Analysis of the enterprise’s historical data reveals that the main reasons for turnover are unclear career development paths and insufficient resources for skill improvement.After pilot implementation,the turnover rate in core departments decreased by 12%,and employee satisfaction with training increased by 24%.The results indicate that matching systematic talent reviews with dynamic learning resources can effectively enhance engineers’sense of belonging.This study provides a set of highly operational management tools for small and medium-sized high-precision,specialized,and innovative technology enterprises,verifies their applicability in such enterprises,and offers replicable experiences for similar enterprises to optimize their talent strategies[1].展开更多
The digital-intelligent era presents both opportunities and challenges for specialized course education in universities.Based on the fundamental task of fostering virtue through education,this study takes the course“...The digital-intelligent era presents both opportunities and challenges for specialized course education in universities.Based on the fundamental task of fostering virtue through education,this study takes the course“Design and Guidance of Science Play Performance Activities”as an example to explore practical pathways for integrating ideological and political education into specialized courses within a digital-intelligent context.Employing literature review and action research methodologies,the study constructs a digital-intelligent teaching model,develops digital ideological and political resources,innovates teaching methods,and systematically identifies and deeply integrates ideological and political elements into the curriculum.Through practical validation,the research summarizes a curriculum design framework grounded in Tyler’s principles and a digital-intelligent teaching model based on BOPPPS,providing transferable pathways for ideological and political education in specialized courses.Furthermore,it offers theoretical support and practical references for the deep integration and innovative application of digital-intelligent technologies in education.展开更多
Objective:To explore the effect of implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure.Methods:Seventy-eight patient...Objective:To explore the effect of implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure.Methods:Seventy-eight patients with severe pneumonia and respiratory failure admitted from January 2024 to February 2025 were selected and randomly divided into two groups using a computer-based random drawing method.The control group(39 patients)received routine nursing,while the observation group(39 patients)received a time-sensitive incentive model combined with specialized rehabilitation nursing.Lung function and adverse emotional states were compared between the two groups.Results:After 2 weeks of nursing,the lung function of the observation group was higher than that of the control group(P<0.05),and the adverse emotional states of the observation group were lower than those of the control group(P<0.05).Conclusion:Implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure can improve lung function and emotional state.展开更多
OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) m...OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalance towards Th2 polarization and epithelial barrier disruption in jejunum and lungs.Chiropractic manipulation helped enhance endogenous SPMs production, which might be one of the action mechanism of chiropractic manipulation on the improvement of epithelial barrier disruption.展开更多
Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized metabolites.These compounds are of importance for adaptive processes,including interactions with various microbes...Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized metabolites.These compounds are of importance for adaptive processes,including interactions with various microbes both beneficial and harmful.Considering microbes as bioreactors,the chemical diversity undergoes dynamic changes when root-derived specialized metabolites(RSMs)and microbes encounter each other in the rhizosphere.Recent advancements in sequencing techniques and molecular biology tools have not only accelerated the elucidation of biosynthetic pathways of RSMs but also unveiled the significance of RSMs in plant-microbe interactions.In this review,we provide a comprehensive description of the effects of RSMs on microbe assembly in the rhizosphere and the influence of corresponding microbial changes on plant health,incorporating the most up-to-date information available.Additionally,we highlight open questions that remain for a deeper understanding of and harnessing the potential of RSM-microbe interactions to enhance plant adaptation to the environment.Finally,we propose a pipeline for investigating the intricate associations between root exometabolites and the rhizomicrobiome.展开更多
Specialized metabolites not only play important roles in biotic and abiotic stress adaptation of tea plants(Camellia sinensis(L.)O.Kuntze)but also contribute to the unique f lavor of tea,the most important nonalcoholi...Specialized metabolites not only play important roles in biotic and abiotic stress adaptation of tea plants(Camellia sinensis(L.)O.Kuntze)but also contribute to the unique f lavor of tea,the most important nonalcoholic beverage.However,the molecular networks and major genes that regulate specialized metabolites in tea plants are not well understood.Here,we constructed a population-level pan-transcriptome of the tea plant leaf using second-leaf transcriptome data from 134 accessions to investigate global expression differences in the population,expression presence or absence variations(ePAVs),and differentially expressed genes(DEGs)between pure Camellia sinensis var.assamica(CSA)and pure Camellia sinensis var.sinensis(CSS)accessions.Next,we used a genome-wide association study,a quantitative trait transcript study,and a transcriptome-wide association study to integrate genotypes,accumulation levels of specialized metabolites,and expression levels of pan-transcriptome genes to identify candidate regulatory genes for f lavor-related metabolites and to construct a regulatory network for specialized metabolites in tea plants.The pan-transcriptome contains 30482 expressed genes,4940 and 5506 of which were newly annotated from a de novo transcriptome assembly without a reference and a genome reference-based assembly,respectively.DEGs and ePAVs indicated that CSA and CSS were clearly differentiated at the population transcriptome level,and they were closely related to abiotic tolerance and secondary metabolite synthesis phenotypes of CSA and CSS based on gene annotations.The regulatory network contained 212 specialized metabolites,3843 candidate genes,and 3407 eQTLs,highlighting many pleiotropic candidate genes,candidate gene-rich eQTLs,and potential regulators of specialized metabolites.These included important transcription factors in the AP2/ERF-ERF,MYB,WD40,and bHLH families.CsTGY14G0001296,an ortholog of AtANS,appeared to be directly related to variation in proanthocyanins in the tea plant population,and the CsTGY11G0002074 gene encoding F3'5'H was found to contribute to the biased distribution of catechins between pure CSAs and pure CSSs.Together,these results provide a new understanding of the metabolite diversity in tea plants and offer new insights for more effective breeding of better-f lavored tea varieties.展开更多
Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages a...Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural economy.In this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in China.The musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience level.The influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future actions.However,heightened exposure to the external macroeconomic environment can lead to a higher rate of export reduction.To enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology and prioritizing the training of technical talent become imperative.展开更多
Nosocomial infections(NIs) are a critical issue affecting the quality of healthcare. In this study, we performed a retrospective study to explore the incidence rates, mortality rates, and microbial spectrum of NIs i...Nosocomial infections(NIs) are a critical issue affecting the quality of healthcare. In this study, we performed a retrospective study to explore the incidence rates, mortality rates, and microbial spectrum of NIs in Beijing Chest Hospital, a tuberculosis(TB) specialized hospital in China. Our data demonstrate that the overall incidence rate of inpatients with NIs slightly decreased from 2012 to 2016, which may be associated with the implementation of hand hygiene measures, while the mortality rates associated with NI did not significantly change. In addition, the species distribution of NIs was quite different from that presented in previous reports, and Klebsiella pneumoniae was the most frequently isolated microorganism.展开更多
Summary: With dwindling number of new antibiotics and inappropriate use of antibiotics, the emergence and spread of antibiotics resistance occurs commonly in healthcare institutions worldwide. In China, antibiotics a...Summary: With dwindling number of new antibiotics and inappropriate use of antibiotics, the emergence and spread of antibiotics resistance occurs commonly in healthcare institutions worldwide. In China, antibiotics are commonly overprescribed and misused. This study is to assess the effect of the nationwide special campaign on antibiotic stewardship program (ASP) at specialized hospitals in China by investigating prescription information from 2011 to 2012. Data on the hospital consumption and prescription of systemic antibiotics were obtained from four specialized hospitals, including maternity, children's, stomatological and cancer hospitals. Systematic random sampling was used to select outpatient prescriptions and inpatient cases. A total of 105 specialized hospitals in 2011 and 121 specialized hospitals in 2012 were analysed. The defined daily doses (DDDs) per 100 inpatient days, the percentage of antibiotic use in outpatient prescriptions, and the percentage of antibiotic use in inpatient eases were used as measurements of antibiotic use. The overall antibiotic use density in the selected hospitals decreased between 2011 and 2012 from 39.37 to 26.54 DDD/100 inpatient days (P〈0.001). The percentage of antibiotic use in outpatient prescriptions (range: 24.12%-18.71%, P=0.109) and inpatient cases (64.85%-60.10%, P=-0.006) also decreased within the two years. Significant changes were observed among regions and different hospitals within the two years. And antibiotic consumption was correlated with the type and size of specialized hospital in 2012, but not with the regions. This analysis of antibiotic consumption of specialized hospitals allows relevant comparisons for benchmarking and shows that national ASP has improved antibiotic rational use in China. The data will assist policymakers in formulating effective strategies to decrease antibiotic overuse and identify areas that require further work.展开更多
The 1,4-naphthoquinones(1,4-NQs)are a diverse group of natural products found in every kingdom of life.Plants,including many horticultural species,collectively synthesize hundreds of specialized 1,4-NQs with ecologica...The 1,4-naphthoquinones(1,4-NQs)are a diverse group of natural products found in every kingdom of life.Plants,including many horticultural species,collectively synthesize hundreds of specialized 1,4-NQs with ecological roles in plant–plant(allelopathy),plant–insect and plant–microbe interactions.Numerous horticultural plants producing 1,4-NQs have also served as sources of traditional medicines for hundreds of years.As a result,horticultural species have been at the forefront of many basic studies conducted to understand the metabolism and function of specialized plant 1,4-NQs.Several 1,4-NQ natural products derived from horticultural plants have also emerged as promising scaffolds for developing new drugs.In this review,the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.An overview on the biochemical mechanisms of action,both from an ecological and pharmacological perspective,of 1,4-NQs derived from horticultural plants is also provided.In addition,future directions for improving basic knowledge about plant 1,4-NQ metabolism are discussed.展开更多
AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE und...AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×80.The magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s classification.Then,a 0.5%solution of methylene blue(MB)was sprayed over columnar mucosa.The patterns of the magnified image and MB staining were analyzed.Biopsies were obtained from the regions previously observed by magnifying endoscopy and MB chromoendoscopy.RESULTS:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have SIM.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have SIM.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.展开更多
基金Supported by the Autonomous Region-level Research and Practice Projects for New Engineering,New Medicine,New Agriculture,and New Humanities of Guangxi Department of Education(XNK202409)the Undergraduate Teaching Reform Project of Guangxi Higher Education(2024JGB332+1 种基金2024JGA304)the Guangxi Degree and Graduate Education Reform Project(JGY2025382).
摘要The construction of new agricultural science has put forward the core requirements of"interdisciplinary integration,service industry demand,and cultivation of composite talents"for the smart agriculture major.The"integration of general and specialized education"is the key path to solve the problems of"prominent disciplinary barriers,fragmented knowledge structure,and weak practical ability"in the traditional curriculum system.In this paper,the College of Smart Agriculture from Yulin Normal University is taken as the research object.Based on the characteristics of regional agricultural industry and the positioning of professional education,the prominent problems in the current professional curriculum system of smart agriculture are analyzed,the construction concept of"strong foundation in general education,precise core in professional education,and breaking through boundaries in integrated education"is proposed,and a"three dimensions and four layers"integrated curriculum system framework for general and specialized education is constructed.Moreover,practical exploration is conducted from the aspects of curriculum module design,teaching mode innovation,and guarantee mechanism construction.Practice has shown that this curriculum system effectively enhances students'interdisciplinary application abilities and industry adaptability,and provides a practical sample for the reform of smart agriculture courses in local universities under the background of new agricultural science.
摘要Faculty development serves as a critical foundation for ensuring the quality of higher education.To meet the needs of cultivating specialized software talents and promoting teaching reform,it is particularly crucial to build a faculty team with knowledge in industry application fields and experience in domestic software development.This paper first analyzes the new requirements for the faculty imposed by the cultivation of specialized software talents and the existing problems in the current faculty.Then,in response to these issues,it introduces the reforms and explorations carried out by the School of Software Engineering at Beijing Jiaotong University in the construction of the faculty for cultivating specialized software talents.The aim is to build a high-caliber and diversified faculty that boasts strong political qualities,interdisciplinary integration,complementary advantages between full-time and part-time faculty,and in-depth integration of industry and education.
摘要Objective:To compare the application effects of routine care and routine care combined with specialized respiratory tract care in patients after cardiothoracic surgery.Methods:This study involved 102 patients who underwent cardiothoracic surgery in our hospital from September 2024 to December 2025.They were randomly divided into a control group(51 cases)and an observation group(51 cases).The control group received routine postoperative care for cardiothoracic surgery,while the observation group received specialized respiratory tract care in addition to routine care.The postoperative recovery,effective expectoration rate,and incidence of postoperative pulmonary complications were compared between the two groups.Results:The observation group had shorter ICU stays,drainage tube indwelling times,and hospital stays than the control group,with p<0.05.The effective expectoration rate in the observation group was higher than that in the control group,with p<0.05.The total incidence of postoperative pulmonary complications in the observation group was lower than that in the control group,with p<0.05.Conclusion:Adding specialized respiratory tract care to routine postoperative care in cardiothoracic surgery can effectively improve the effective expectoration rate,reduce the incidence of pulmonary complications,and promote postoperative recovery in patients.
摘要Within contemporary healthcare systems, professional identity among specialized nurses serves as a pivotal intrinsic factor influencing the development of their core competencies. This review synthesizes existing research, revealing that professional identity positively impacts the development of core competencies through multiple pathways, including psychological drive, behavioral facilitation, teamwork, and career stability. Building on this analysis, this paper proposes systematic enhancement strategies from four dimensions: education and training, organizational environment, cultural development, and individual growth, aiming to provide a reference for nursing practice and professional development.
摘要Objective:This paper focuses on a comprehensive analysis of the overall framework and core operational points of specialized,systematic nursing interventions for children with brain abscesses undergoing complete antimicrobial therapy,and explores the practical effects of such structured nursing models on enhancing treatment compliance,preventing related complications,and improving long-term neurological recovery.Methods:A cohort analysis model incorporating both retrospective and prospective features was designed.The study subjects were identified as 76 pediatric patients admitted from early 2020 to the end of 2023,diagnosed with brain abscesses,and who completed the prescribed anti-infective treatment course.Based on different clinical nursing pathways adopted,all cases were equally divided into two groups:a control group receiving standard routine care(38 cases)and a practice group applying a specialized integrated nursing protocol designed for this study(38 cases).This specialized protocol systematically integrates four dimensions:precise monitoring of intracranial pressure changes,a full-process management strategy for antimicrobial drug use,neurological function maintenance measures,and a family-centered educational support plan.The study comprehensively recorded various clinical observation indicators for both groups during treatment.Results:Data analysis revealed that the practice group adopting the specialized nursing protocol demonstrated superiority across multiple evaluation indicators.The effective symptom control rate during treatment(94.7%vs.78.9%,p<0.05),the incidence of adverse events induced by treatment drugs(10.5%vs.28.9%,p<0.05),and the qualification rate of primary caregivers of the children in mastering relevant knowledge and skills(92.1%vs.71.1%,p<0.05)were all significantly better than those in the routine care group.Additionally,the practice group showed statistically significant reductions in time-sensitive indicators such as the average number of days required for fever resolution,the time for relief of meningeal irritation signs,and the overall length of hospital stay(all comparisons p<0.05).In the follow-up Glasgow Outcome Scale scores conducted three months after treatment completion,the proportion of cases in the practice group achieving a good prognosis(scores of 4 to 5)reached 86.8%,significantly higher than the 68.4%in the control group(p<0.05).Conclusion:A multi-component,interlinked specialized nursing practice developed around and deeply integrated with the anti-infective treatment mainline can clearly enhance the safety level and overall efficiency of clinical management for pediatric brain abscesses.
基金The 2018 Ministry of Education Industry-University Cooperation Collaborative Education Project“Construction of Experimental Conditions and Practice Base”(Project No.:201801012048)。
摘要In the deep-water zone of the global digital economy in 2026,the survival rules for“Specialized,Refined,and Innovative”SMEs are undergoing a fundamental shift.Artificial Intelligence(AI)has evolved from an efficiency tool into a“digital foundation”that anchors corporate positions amidst uncertainty.This paper examines the new commercial paradigm of“digital resilience”through empirical research on 312 representative enterprises in the Greater Bay Area and case studies of hard-tech leaders in Beijing.Findings indicate that AI adoption significantly enhances a firm’s ability to perceive and recover from supply chain shocks.The study concludes that the integration of industry deep-plowing and AI investment creates an asymmetric competitive advantage,forming a“flexible moat”for sustainable growth.
基金Clinical Study on the Treatment of Ischemic Brain Injury with Human Neural Progenitor Cell(hNPC)Transplantation(Project No.:2021YFA1101703/2021YFA1101700)。
摘要Stereotactic multi-target precise transplantation of stem cells into the brain is an innovative neural repair approach that integrates minimally invasive neurosurgery and regenerative medicine.Under precise image guidance,stem cells can be delivered accurately into ischemic-injured areas and functional nuclei,thereby promoting neural circuit reconstruction and neurological function recovery.With the clinical transformation of this technique,establishing a systematic,standardized,and specialized nursing system is crucial to ensure surgical safety,reduce intracranial complications,improve therapeutic effect,and accelerate neurological recovery.Based on the technical characteristics,repair mechanisms and pathophysiological features of ischemic brain injury,this study constructed a comprehensive specialized nursing system including perioperative management,intraoperative cooperation,complication monitoring,immune rejection control,rehabilitation training,psychological intervention and continuous follow-up,so as to provide a reliable reference for clinical nursing practice.
摘要BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive symptoms in postmenopausal women with osteoporosis and develop targeted psychological nursing interven-tions.METHODS A total of 180 postmenopausal women with osteoporosis admitted to the Depar-tment of Orthopedics at the First Affiliated Hospital of Soochow University between October 2021 and October 2024 were selected as research participants.Information on age,duration of menopause,body mass index,education level,marital status,activity intensity,bone density,presence of chronic diseases,calcium supplement intake,sex hormone levels,and depressive symptoms were collected.The 24-item Hamilton Depression Scale was used for assessment.RESULTS Forty-eight patients had no depressive symptoms,and 132 patients had depre-ssive symptoms.Comprehensive univariate and multivariate logistic regression analyses showed that low bone density in the lumbar spine(L2-L4)and femoral neck,presence of chronic diseases,and low 5-hydroxytryptamine levels were independent risk factors for depressive symptoms,whereas calcium supplement intake and moderate to high-intensity activity were independent protective factors.CONCLUSION By implementing specialized psychological nursing interventions,and providing rehabilitation guidance,the incidence of depressive symptoms can be effectively reduced,improving the psychological health status and patient quality of life.
摘要Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received treatment at our hospital from May 2022 to December 2024 were selected as study subjects.The patients were randomly divided into a control group and an observation group,with 94 patients in each group.The control group received routine nursing intervention,while the observation group received specialized nursing intervention.The general information,swallowing function,quality of life,and nursing satisfaction were compared between the two groups.Results:There was no statistically significant difference in general information between the two groups(P>0.05).The SAS score of the observation group after nursing was significantly lower than that of the control group(t=19.463,P=0.000<0.001).After intervention,the number of patients with lung infection in the observation group was significantly lower than that in the control group(χ2=7.309,P=0.007<0.01).The overall quality of life score of the observation group was significantly better than that of the control group after intervention(P<0.001).The nursing satisfaction of the observation group was significantly higher than that of the control group(χ2=15.865,P=0.000<0.001).Conclusion:Compared with routine care,specialized nursing intervention can effectively improve the swallowing function of patients with dysphagia during acute stroke,enhance their quality of life,and increase nursing satisfaction.
摘要With the intensifying competition in the integrated circuit(IC)industry,the high turnover rate of integrated circuit engineers has become a prominent issue affecting the technological continuity of high-precision,specialized,and innovative enterprises.As a representative of such enterprises,JL Technology has faced challenges to its R&D efficiency due to talent loss in recent years.This study takes this enterprise as a case to explore feasible paths to reduce turnover rates through optimizing training and career development systems.The research designs a method combining learning maps and talent maps,utilizes a competency model to clarify the direction for engineers’skill improvement,implements talent classification management using a nine-grid model,and achieves personalized training through Individual Development Plans(IDPs).Analysis of the enterprise’s historical data reveals that the main reasons for turnover are unclear career development paths and insufficient resources for skill improvement.After pilot implementation,the turnover rate in core departments decreased by 12%,and employee satisfaction with training increased by 24%.The results indicate that matching systematic talent reviews with dynamic learning resources can effectively enhance engineers’sense of belonging.This study provides a set of highly operational management tools for small and medium-sized high-precision,specialized,and innovative technology enterprises,verifies their applicability in such enterprises,and offers replicable experiences for similar enterprises to optimize their talent strategies[1].
基金funded by the Scientific Research Project of Lingnan Normal Universitythe following projects and centers at Lingnan Normal University:the Special Project on Party Building and Ideological-Political Education—“Practical Research on‘Curriculum Ideology and Politics’in Universities under the Concept of‘Three-Wide Education’”(WD2424)+1 种基金the Science Education Special Project—“Research on Implementation Strategies for High-Quality Development of Science Popularization Education Based on Scientific Activities”(KX2404)the Ideological-Political Education Teaching Demonstration Center of the School of Physics(PX-4825706).
摘要The digital-intelligent era presents both opportunities and challenges for specialized course education in universities.Based on the fundamental task of fostering virtue through education,this study takes the course“Design and Guidance of Science Play Performance Activities”as an example to explore practical pathways for integrating ideological and political education into specialized courses within a digital-intelligent context.Employing literature review and action research methodologies,the study constructs a digital-intelligent teaching model,develops digital ideological and political resources,innovates teaching methods,and systematically identifies and deeply integrates ideological and political elements into the curriculum.Through practical validation,the research summarizes a curriculum design framework grounded in Tyler’s principles and a digital-intelligent teaching model based on BOPPPS,providing transferable pathways for ideological and political education in specialized courses.Furthermore,it offers theoretical support and practical references for the deep integration and innovative application of digital-intelligent technologies in education.
摘要Objective:To explore the effect of implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure.Methods:Seventy-eight patients with severe pneumonia and respiratory failure admitted from January 2024 to February 2025 were selected and randomly divided into two groups using a computer-based random drawing method.The control group(39 patients)received routine nursing,while the observation group(39 patients)received a time-sensitive incentive model combined with specialized rehabilitation nursing.Lung function and adverse emotional states were compared between the two groups.Results:After 2 weeks of nursing,the lung function of the observation group was higher than that of the control group(P<0.05),and the adverse emotional states of the observation group were lower than those of the control group(P<0.05).Conclusion:Implementing a time-sensitive incentive model combined with specialized rehabilitation nursing in patients with severe pneumonia and respiratory failure can improve lung function and emotional state.
基金Supported by the National Natural Science Foundationfunded Project:the Mechanism of Spine-pinching Manipulation via Inflammation Regulation of SPMs on Prevention and Treatment of Spleen-deficiency Asthma(No.81774446)
摘要OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalance towards Th2 polarization and epithelial barrier disruption in jejunum and lungs.Chiropractic manipulation helped enhance endogenous SPMs production, which might be one of the action mechanism of chiropractic manipulation on the improvement of epithelial barrier disruption.
基金National Key Research and Development Program of China(2018YFA0900603 to G.W.and 2022YFF1001800 to Y.B.)the National Natural Science Foundation of China(grant No.32000232)to X.W.the State Key Laboratory of Plant Genomics of China(SKLPG2016A-13)to G.W.
摘要Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized metabolites.These compounds are of importance for adaptive processes,including interactions with various microbes both beneficial and harmful.Considering microbes as bioreactors,the chemical diversity undergoes dynamic changes when root-derived specialized metabolites(RSMs)and microbes encounter each other in the rhizosphere.Recent advancements in sequencing techniques and molecular biology tools have not only accelerated the elucidation of biosynthetic pathways of RSMs but also unveiled the significance of RSMs in plant-microbe interactions.In this review,we provide a comprehensive description of the effects of RSMs on microbe assembly in the rhizosphere and the influence of corresponding microbial changes on plant health,incorporating the most up-to-date information available.Additionally,we highlight open questions that remain for a deeper understanding of and harnessing the potential of RSM-microbe interactions to enhance plant adaptation to the environment.Finally,we propose a pipeline for investigating the intricate associations between root exometabolites and the rhizomicrobiome.
基金funded by the Key-Area Research and Development Program of Guangdong Province(2020B020220004)the Shenzhen Science and Technology Program(Grant No.RCYX20210706092103024)the National Key Research and Development Program of China(2021YFF1000900).
摘要Specialized metabolites not only play important roles in biotic and abiotic stress adaptation of tea plants(Camellia sinensis(L.)O.Kuntze)but also contribute to the unique f lavor of tea,the most important nonalcoholic beverage.However,the molecular networks and major genes that regulate specialized metabolites in tea plants are not well understood.Here,we constructed a population-level pan-transcriptome of the tea plant leaf using second-leaf transcriptome data from 134 accessions to investigate global expression differences in the population,expression presence or absence variations(ePAVs),and differentially expressed genes(DEGs)between pure Camellia sinensis var.assamica(CSA)and pure Camellia sinensis var.sinensis(CSS)accessions.Next,we used a genome-wide association study,a quantitative trait transcript study,and a transcriptome-wide association study to integrate genotypes,accumulation levels of specialized metabolites,and expression levels of pan-transcriptome genes to identify candidate regulatory genes for f lavor-related metabolites and to construct a regulatory network for specialized metabolites in tea plants.The pan-transcriptome contains 30482 expressed genes,4940 and 5506 of which were newly annotated from a de novo transcriptome assembly without a reference and a genome reference-based assembly,respectively.DEGs and ePAVs indicated that CSA and CSS were clearly differentiated at the population transcriptome level,and they were closely related to abiotic tolerance and secondary metabolite synthesis phenotypes of CSA and CSS based on gene annotations.The regulatory network contained 212 specialized metabolites,3843 candidate genes,and 3407 eQTLs,highlighting many pleiotropic candidate genes,candidate gene-rich eQTLs,and potential regulators of specialized metabolites.These included important transcription factors in the AP2/ERF-ERF,MYB,WD40,and bHLH families.CsTGY14G0001296,an ortholog of AtANS,appeared to be directly related to variation in proanthocyanins in the tea plant population,and the CsTGY11G0002074 gene encoding F3'5'H was found to contribute to the biased distribution of catechins between pure CSAs and pure CSSs.Together,these results provide a new understanding of the metabolite diversity in tea plants and offer new insights for more effective breeding of better-f lavored tea varieties.
基金Under the auspices of the China Social Science(No.21BJY218)National Natural Science Foundation of China(No.41801113)Newcomer funding from Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences(No.E0V00100)。
摘要Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural economy.In this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in China.The musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience level.The influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future actions.However,heightened exposure to the external macroeconomic environment can lead to a higher rate of export reduction.To enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology and prioritizing the training of technical talent become imperative.
摘要Nosocomial infections(NIs) are a critical issue affecting the quality of healthcare. In this study, we performed a retrospective study to explore the incidence rates, mortality rates, and microbial spectrum of NIs in Beijing Chest Hospital, a tuberculosis(TB) specialized hospital in China. Our data demonstrate that the overall incidence rate of inpatients with NIs slightly decreased from 2012 to 2016, which may be associated with the implementation of hand hygiene measures, while the mortality rates associated with NI did not significantly change. In addition, the species distribution of NIs was quite different from that presented in previous reports, and Klebsiella pneumoniae was the most frequently isolated microorganism.
基金supported by grants from the General Program of National Natural Science Foundation of China(No.71073062)Major Project in Philosophy and Social Science of Ministry of Education in China(No.10JZD0027)
摘要Summary: With dwindling number of new antibiotics and inappropriate use of antibiotics, the emergence and spread of antibiotics resistance occurs commonly in healthcare institutions worldwide. In China, antibiotics are commonly overprescribed and misused. This study is to assess the effect of the nationwide special campaign on antibiotic stewardship program (ASP) at specialized hospitals in China by investigating prescription information from 2011 to 2012. Data on the hospital consumption and prescription of systemic antibiotics were obtained from four specialized hospitals, including maternity, children's, stomatological and cancer hospitals. Systematic random sampling was used to select outpatient prescriptions and inpatient cases. A total of 105 specialized hospitals in 2011 and 121 specialized hospitals in 2012 were analysed. The defined daily doses (DDDs) per 100 inpatient days, the percentage of antibiotic use in outpatient prescriptions, and the percentage of antibiotic use in inpatient eases were used as measurements of antibiotic use. The overall antibiotic use density in the selected hospitals decreased between 2011 and 2012 from 39.37 to 26.54 DDD/100 inpatient days (P〈0.001). The percentage of antibiotic use in outpatient prescriptions (range: 24.12%-18.71%, P=0.109) and inpatient cases (64.85%-60.10%, P=-0.006) also decreased within the two years. Significant changes were observed among regions and different hospitals within the two years. And antibiotic consumption was correlated with the type and size of specialized hospital in 2012, but not with the regions. This analysis of antibiotic consumption of specialized hospitals allows relevant comparisons for benchmarking and shows that national ASP has improved antibiotic rational use in China. The data will assist policymakers in formulating effective strategies to decrease antibiotic overuse and identify areas that require further work.
基金This work was supported by start-up funds from Purdue University to JRW.
摘要The 1,4-naphthoquinones(1,4-NQs)are a diverse group of natural products found in every kingdom of life.Plants,including many horticultural species,collectively synthesize hundreds of specialized 1,4-NQs with ecological roles in plant–plant(allelopathy),plant–insect and plant–microbe interactions.Numerous horticultural plants producing 1,4-NQs have also served as sources of traditional medicines for hundreds of years.As a result,horticultural species have been at the forefront of many basic studies conducted to understand the metabolism and function of specialized plant 1,4-NQs.Several 1,4-NQ natural products derived from horticultural plants have also emerged as promising scaffolds for developing new drugs.In this review,the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.An overview on the biochemical mechanisms of action,both from an ecological and pharmacological perspective,of 1,4-NQs derived from horticultural plants is also provided.In addition,future directions for improving basic knowledge about plant 1,4-NQ metabolism are discussed.
摘要AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×80.The magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s classification.Then,a 0.5%solution of methylene blue(MB)was sprayed over columnar mucosa.The patterns of the magnified image and MB staining were analyzed.Biopsies were obtained from the regions previously observed by magnifying endoscopy and MB chromoendoscopy.RESULTS:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have SIM.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have SIM.The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.