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Therapeutic effects of low-intensity transcranial focused ultrasound stimulation on ischemic stroke in rats:An in vivo evaluation using electrical impedance tomography 认领 引用 被引量：1
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作者 Jiecheng Guo Sixuan He +4 位作者 Li Yan Lei Wang Xuetao Shi Huijing Hu Le Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1183-1190,共8页
Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance to... Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke. 展开更多
关键词 animal model brain stimulation electrical impedance tomography evaluation impedance noninvasive treatment real-time monitoring rehabilitation stroke transcranial focused ultrasound stimulation
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Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model 认领 引用 被引量：5
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作者 Jingjun Zhang Ming Ding +11 位作者 Lu Luo Dan Huang Siyue Li Shuying Chen Yunhui Fan Li Liu Hongyu Xie Gang Liu Kewei Yu Junfa Wu Xiao Xiao Yi Wu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3598-3608,共11页
The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Int... The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Intermittent theta-burst stimulation is a repetitive transcranial magnetic stimulation that operates within the theta wave range and can either promote or inhibit cortical excitability.Previous studies have shown that intermittent theta wave stimulation has neuroprotective effects,but the underlying mechanisms remain unclear.In this study,mice subjected to middle cerebral artery occlusioneperfusion were treated with intermittent theta-burst stimulation.The results showed that intermittent theta-burst stimulation significantly improved neurological function and motor recovery,reduced apoptosis in the peri-infarct region,and activated the PI3K/AKT/GSK3β/β-catenin signaling pathway.Additionally,intermittent theta-burst stimulation suppressed inflammation through the PI3K/AKT/GSK3βand NF-κB pathways.Notably,intermittent theta-burst stimulation strengthened A2 astrocyte-blood vessel coupling,and the effects of intermittent theta-burst stimulation were reversed by the PI3K inhibitor LY294002.These findings demonstrate that intermittent theta-burst stimulation promotes neurovascular unit remodeling and improves neurological outcomes by modulating microglia and astrocytes via the PI3K/AKT/GSK3βand NF-κB signaling pathways. 展开更多
关键词 astrocyte blood-brain barrier glycogen synthase kinase 3 beta intermittent theta-burst stimulation ischemic stroke microglia neural protection neuroinflammation neurovascular unit vascular protection
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Spinal cord stimulation:An emerging strategy for chronic pain relief after spinal cord injury 认领 引用 被引量：1
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作者 Qiwen Wang Ying Zhang +1 位作者 Huifeng Zhang Zhonghai Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第8期3336-3348,共13页
Chronic pain following a spinal cord injury refers to pain that persists or recurs after the injury.This pain can manifest as burning,stinging,or sensations similar to electric shocks.Recent studies have shown that sp... Chronic pain following a spinal cord injury refers to pain that persists or recurs after the injury.This pain can manifest as burning,stinging,or sensations similar to electric shocks.Recent studies have shown that spinal cord stimulation is an effective way to treat chronic pain after spinal cord injury.The purpose of this review is to introduce the technique of spinal cord stimulation,the clinical manifestations of spinal cord injury,and the role of spinal cord stimulation in the treatment of spinal cord injury.The mechanism and clinical application of spinal cord stimulation in the treatment of pain after spinal cord injury are discussed.The mechanism of spinal cord stimulation primarily involves three aspects:neuromodulation,neurochemical regulation,and anti-inflammatory effects,along with nerve repair.In terms of neuromodulation,spinal cord stimulation is based on the gate control theory of pain.It activates large-diameter amyloid-β nerve fibers to promote the release of inhibitory neurotransmitters by gamma-aminobutyric acidergic inhibitory interneurons in the spinal cord,thereby blocking the transmission of pain signals from small-diameter C fibers.Neurochemical studies indicate that spinal cord stimulation can regulate the balance of neurotransmitters within the spinal cord,increasing the release of inhibitory neurotransmitters such as gamma-aminobutyric acid,serotonin,and acetylcholine while reducing the levels of excitatory neurotransmitters.Additionally,spinal cord stimulation exhibits significant anti-inflammatory and neuroprotective effects,downregulating pro-inflammatory factor levels,upregulating anti-inflammatory factor expression,alleviating neuroinflammatory responses,and repairing damaged neural circuits by promoting the secretion of neurotrophic factors and axonal regeneration.Spinal cord stimulation have demonstrated remarkable efficacy in the clinical treatment of pain after spinal cord injury,but there are still limitations such as small sample size and high heterogeneity in clinical studies,as well as insufficient long-term efficacy data.Future research should conduct multi-center large-sample randomized controlled trials,and establish long-term follow-up mechanisms to improve evidence-based medical evidence. 展开更多
关键词 chronic pain electric stimulation therapy GABAergic neurons nerve regeneration neuroinflammatory diseases neuronal plasticity neuropathic pain neuroprotection pain management spinal cord injuries spinal cord stimulation
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Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing 认领 引用 被引量：1
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作者 Lijuan Zong Chong Liu +11 位作者 Li Zhang Xueyou Tao Qingyan Tian Xiaokai Zhou Yu Wang Na Shen Jiaming Gong Qingyuan Zhuang Tong Wang Wentao Liu Ying Shen Liang Hu 《Journal of Biomedical Research》 CAS CSCD 2026年第2期120-133,共14页
Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited ... Neuromuscular electrical stimulation(NMES)is a well-established therapeutic approach for chronic wounds.Conventionally,NMES involves direct electrode contact with wounds or adjacent healthy skin;however,it is limited by the need for wound exposure and by increased pain.Our preliminary study demonstrated the innovative application of remote NMES(rNMES)to the skeletal muscle of the distal calf,which showed the potential to accelerate wound healing in remote areas.rNMES was effective in human clinical trials in our previous work,although the underlying mechanisms remain unclear.As rNMES is often used to stimulate muscle contraction in long-term bedridden patients,we analyzed data from the Gene Expression Omnibus(GEO)database and found that exercise promotes midkine(MDK)expression in muscle.MDK is a small secreted heparin-binding protein that interacts with multiple cell surface receptors to promote growth.In the present study,we found that MDK significantly enhanced macrophage efferocytosis in a low-density lipoprotein receptor-related protein 1(LRP1)-dependent manner.Our findings demonstrate that rNMES upregulates MDK expression in skeletal muscles through the AMPK-ERK axis,facilitating its delivery to wounds through the circulatory system and promoting LRP1-mediated efferocytosis of apoptotic cells,thereby expediting wound healing. 展开更多
关键词 wound healing remote neuromuscular electrical stimulation efferocytosis MDK LRP1
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Electric field stimulation-responsive hydrogels for bone regeneration:from mechanisms to applications 认领 引用
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作者 Lizhi Ouyang Xi He +12 位作者 Yuheng Liao Xing Zhou Jiewen Liao Ze Lin Xudong Xie Weixian Hu Wenqian Zhang Fawwaz Al-Smadi Ranyang Tao Faqi Cao Yiqiang Hu Guohui Liu Bobin Mi 《Bone Research》 SCIE CAS CSCD 2026年第1期82-108,共27页
The continuous extension of human life expectancy and the global trend of population aging have contributed to a marked increase in the incidence of musculoskeletal diseases,with fractures and osteoporosis being promi... The continuous extension of human life expectancy and the global trend of population aging have contributed to a marked increase in the incidence of musculoskeletal diseases,with fractures and osteoporosis being prominent examples.Consequently,promoting bone regeneration is a crucial medical challenge that demands immediate attention.As early as the mid-20th century,researchers revealed that electrical stimulation could effectively promote the healing and regeneration of bone tissue.This is achieved by mimicking the endogenous electric field within bone tissue,which influences cellular behavior and molecular mechanisms.In recent years,electroactive hydrogels responsive to electric field stimulation have been developed and applied to regulate cell functions at different stages of bone regeneration.This paper elaborates on the regulatory effects of electrical stimulation on MSCs,macrophages,and vascular endothelial cells during the process of bone regeneration.It also involves the activation of relevant ion channels and signaling pathways.Subsequently,it comprehensively reviews various electric-field-responsive hydrogels developed in recent years,covering aspects such as material selection,preparation methods,characteristics,and their applications in bone regeneration.Ultimately,it provides an objective summary of the existing deficiencies in hydrogel materials and research,and looks ahead to future development directions. 展开更多
关键词 electrical stimulation mesenchymal stem cells macrophages hydrogels bone regeneration musculoskeletal diseaseswith population aging electric field stimulation
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Acupoint stimulation for pain management in patients after transcatheter arterial chemoembolization: A systematic review and meta-analysis 认领 引用
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作者 Wen-yi WANG Xiao-min QUAN +4 位作者 Ze-yu HE Hong-yang CHEN Xun LI Guan-hu YANG Chao AN 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第1期29-43,共15页
Objective:To systematically evaluate the clinical efficacy of acupoint stimulation for managing posttranscatheter arterial chemoembolization(TACE) pain and to provide a reliable evidence-based foundation for its clini... Objective:To systematically evaluate the clinical efficacy of acupoint stimulation for managing posttranscatheter arterial chemoembolization(TACE) pain and to provide a reliable evidence-based foundation for its clinical application in post-TACE pain management.Methods:Clinical randomized controlled trials evaluating acupoint stimulation for post-TACE pain were retrieved from the Chinese National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,VIP Chinese Science and Technology Journal Database,China Biology Medicine disc,PubMed,Embase,Web of Science,the Cochrane Library,and ClinicalTrials.gov,covering all records from database inception to July 28,2025.Articles were screened and data were extracted according to predefined inclusion and exclusion criteria.The methodological quality of the included studies was assessed using the Cochrane Risk of Bias Assessment Tool.Statistical analyses were conducted using Review Manager 5.4.1and Stata 15.0.The certainty of evidence for each outcome was evaluated using the Grading of Recommendations Assessment,Development,and Evaluation approach.This study was registered on PROSPERO(CRD420251108966).Results:A total of 17 studies involving 1525 patients with liver cancer who experienced acute postoperative pain following TACE were included.Meta-analysis results demonstrated that acupoint stimulation significantly reduced pain intensity scores(Numerical rating scale:mean difference [MD]=-0.83,95 %confidence interval [CI] [-0.96,-0.71], P <0.00001;Visual analog scale:MD=-1.15,95 % CI [-1.67,-0.63],P <0.0001),increased the complete pain remission rate(Risk ratio [RR]=1.74,95% CI [1.35,2.23],P <0.0001),shortened the onset time of analgesia(MD=-25.39 min,95 % CI [-27.53,-23.26],P <0.00001),prolonged the duration of analgesia(MD=3.03 h,95% CI [0.40,5.66],P=0.02),and reduced the need for rescue analgesics(RR=0.43,95% CI [0.28,0.64],P <0.0001).Furthermore,acupoint stimulation improved liver function indicators(Alanine aminotransferase:MD=-5.27 U/L,95%CI [-6.90,-3.63],P <0.00001;Aspartate aminotransferase:MD=-6.76 U/L,95 % CI [-8.39,-5.12],P <0.00001),lowered plasma substance P levels(MD=-18.28 ng/L,95% CI [-30.97,-5.60],P=0.005),and enhanced patient satisfaction(RR=1.33,95% CI [1.05,1.69],P=0.02).Regarding safety,acupoint stimulation significantly reduced the risk of adverse events compared with blank controls(RR=0.24,95% CI [0.10,0.56],P=0.001).However,no statistically significant differences in the risk of adverse events were observed when acupoint stimulation was combined with analgesics(RR=0.91,95 % CI [0.39,2.13],P=0.82) or compared directly to analgesics alone(RR=0.79,95% CI [0.04,14.95],P=0.87).Conclusion:Acupoint stimulation demonstrates favorable effects in alleviating pain following TACE.However,the relatively low methodological quality of the included studies limits the strength of the conclusions.Additional high-quality studies are needed to provide more robust evidence to guide clinical practice. 展开更多
关键词 Acupoint stimulation Transcatheter arterial chemoembolization Postoperative pain Liver cancer Meta-analysis
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Molecular signaling effects of electrical stimulation of the soleus muscle during 6 days of dry immersion 认领 引用
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作者 Kristina A.Sharlo Irina D.Lvova +7 位作者 Natalya A.Vilchinskaya Sergey A.Tyganov Olga V.Turtikova Ksenia V.Sergeeva Roman O.Bokov Boris S.Shenkman Elena S.Tomilovskaya Oleg I.Orlov 《Sports Medicine and Health Science》 CAS CSCD 2026年第3期335-349,共15页
Background:Unloading of skeletal muscles triggers rapid changes in molecular signaling,leading to muscle atrophy and functional alterations.Electrical stimulation of muscles is commonly used to counteract these change... Background:Unloading of skeletal muscles triggers rapid changes in molecular signaling,leading to muscle atrophy and functional alterations.Electrical stimulation of muscles is commonly used to counteract these changes,but the precise molecular mechanisms behind its effects remain unclear.Methods:To investigate the early changes in postural soleus muscle under unloading conditions(dry immersion,DI)and the impact of electrical stimulation during unloading,two groups of volunteers(10 men in each)underwent a 6-day DI or a 6-day DI with electrical stimulation(DI+ES).Soleus muscle samples were collected 14 days before and 6 days after DI and DI+ES.Results:Six-day DI did not did not cause atrophy of the soleus myofibers or alter protein synthesis parameters,However,it did lead to an increase in atrogin-1 expression,a downregulation of markers for mitochondrial biogenesis and dynamics,and a decline in the mRNA expression of fast oxidative myosin isoform IIa.It also resulted in the downregulation of microRNAs mir-206 and mir-208b,which support slow fiber types.There was an upregulation of CpG methylation in the peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC1a)promoter region and an accumulation of Ca2+/calmodulin-dependent protein kinase(p-CaMK II),indicating an increase in myoplasmic calcium levels.Electrical stimulation during the 6-day disuse period prevented the disuse-induced decreases in mitochondria-related markers and the content of mir-206 and mir-208b.It also induced a shift in myosin m RNA expression from types IId/x to IIa,counteracted the accumulation of p-CaMK II and CpG methylation in the PGC1a promoter region.Conclusions:Electrical stimulation upregulated markers of both protein synthesis and proteolysis,as well as resulted in lower cross-sectional area of fast-type fibers compared to pre-DI+ES. 展开更多
关键词 Dry immersion Muscle disuse Electrical stimulation Muscle signaling
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A preclinical rat model for bilateral phrenic nerve stimulation during mechanical ventilation 认领 引用
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作者 Jingyi Li Mulin Zhang +5 位作者 Meizhizi Zhang Fenqin Xue Zhize Gao Xiang Qi Yongxing Sun Zhonghua Shi 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第2期416-421,共6页
Phrenic nerve stimulation(PNS)may preserve diaphragm activation and mitigate multiorgan injury during mechanical ventilation(MV);however,a minimal invasive rat model integrating PNS with MV is lacking.We established a... Phrenic nerve stimulation(PNS)may preserve diaphragm activation and mitigate multiorgan injury during mechanical ventilation(MV);however,a minimal invasive rat model integrating PNS with MV is lacking.We established an omohyoid muscle-based PNS rat model combined with MV.Bilateral nerves were exposed within 20±2 min by transection at the intermediate tendon of omohyoid muscle,minimizing trauma and bleeding.Threshold stimulation(0.6±0.2 mA)correlated with body weight.Ventilator-synchronized stimulation increased compound muscle action potentials by~30%,whereas histology confirmed intact nerve.Physiological parameters remained stable throughout ventilation.This model provides a safe and scalable platform for mechanistic and preclinical studies on PNS-mediated protection against MV-induced organ injury. 展开更多
关键词 diaphragm electromyography mechanical ventilation omohyoid-based surgery phrenic nerve stimulation rat model
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Targeted optogenetic stimulation of the thalamic reticular nucleus:A novel strategy for modulating epileptiform discharges 认领 引用
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作者 Zhi-Hui Wang Jia-Hui Yang Li-Xia Duan 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第6期352-367,共16页
The distinct advantage of optogenetic stimulation in precise neuromodulation enables us to dissect the intrinsic mechanisms by which such stimulation of the thalamic reticular nucleus(RE)suppresses epileptic seizures.... The distinct advantage of optogenetic stimulation in precise neuromodulation enables us to dissect the intrinsic mechanisms by which such stimulation of the thalamic reticular nucleus(RE)suppresses epileptic seizures.Since irradiance(Irr)is a key factor affecting optogenetic stimulation,we first explore the effect of Irr on epileptic seizures.The results indicate that increasing Irr can suppress the seizures and alter the system's bifurcation structure.The numbers of Hopf bifurcations and saddle–node bifurcations of limit cycles decrease as Irr increases,and the saddle–node bifurcation of the fixed point is a key factor driving the abrupt transition of the system from a high-saturation discharge state to a low-saturation discharge state.Subsequently,we apply optogenetic stimulation in square-wave and Gaussian pulse forms to assess the impacts of three core parameters(pulse width ws,pulse frequency f,and Irr)on epileptic discharge states.Our numerical simulation results reveal that square-wave pulsed optogenetic stimulation effectively suppresses seizure activity when the pulse width is increased to 15 ms(f=40 Hz,Irr=0.3 mW/mm2),the pulse frequency to 100 Hz(ws=5 ms,Irr=0.3 mW/mm2),and the irradiance to 0.8 mW/mm2(ws=5 ms,f=40 Hz),respectively.In contrast,using the same analytical method,we find that Gaussian pulsed stimulation requires elevating the respective parameters(pulse width,frequency,irradiance)to 30 ms,250 Hz,and 1.9 mW/mm2 for the effective suppression of seizure activity.Therefore,square-wave pulses require a smaller parameter threshold to achieve the effect of inhibiting epileptic seizures.From a physiological perspective,square-wave pulsed optogenetic stimulation is thus more suitable as a potential candidate for clinical trials. 展开更多
关键词 optogenetic stimulation square-wave pulse Gaussian pulse bifurcation analysis
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Signal propagation of a feedforward neural network under electromagnetic stimulation 认领 引用
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作者 Huilan Yang Wei Zhang Junjie Bao 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第6期343-351,共9页
Cortical networks exhibit distinct layered characteristics,with neurons in each layer collectively responsible for the transmission and processing of external signals.Information transfer between different regions and... Cortical networks exhibit distinct layered characteristics,with neurons in each layer collectively responsible for the transmission and processing of external signals.Information transfer between different regions and layers of the cerebral cortex is crucial for information processing in the nervous system.Investigating signal propagation among neural networks helps us understand the top-down or bottom-up information transmission mechanisms of the nervous system.In this study,a five-layer feedforward neural network with time delay was constructed.By calculating the discharge timing,signal-tonoise ratio,and population Fano factor of the multi-layer neural network,the characteristics of signal propagation between different levels of the nervous system under electromagnetic stimulation were investigated.The results show that the delay time has a significant impact on signal propagation;under appropriate delay time conditions,the neural network can achieve effective signal propagation.Electromagnetic stimulation can significantly improve the signal-to-noise ratio of neural network signal propagation,shorten the signal propagation time,and enhance the stability of signal propagation.This study not only provides an important theoretical basis for revealing the regulatory mechanisms of signal transmission between different levels of the nervous system but also offers useful references for the future development of electromagnetic neural modulation technologies and the treatment of diseases related to impaired signal transmission in the nervous system. 展开更多
关键词 neural networks signal propagation electromagnetic stimulation time delay
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Anti-inflammatory and osteogenic effects of transcutaneous electrical nerve stimulation in knee osteoarthritis rats via the regulation of the intestinal microbiota 认领 引用
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作者 Yan Sun Tong Ma +4 位作者 Ran Chen Lan Shen Xun Tang Zhiqiang Shen Hongbin Zhao 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第6期1217-1234,共18页
Background:This study revealed the function and mechanism of the intestinal microbiota in knee osteoarthritis(KOA)rats treated using transcutaneous electrical nerve stimulation(TENS).Methods:KOA model rats were random... Background:This study revealed the function and mechanism of the intestinal microbiota in knee osteoarthritis(KOA)rats treated using transcutaneous electrical nerve stimulation(TENS).Methods:KOA model rats were randomly divided into low−/medium−/high-intensity TENS groups,sodium hyaluronate(SH)-positive control group(SH),and model control group(KOA rat).After 1,2,and 3 weeks of treatment,the improvement in KOA severity was assessed,and the expression of interleukin-1β(IL-1β)/IL-6/IL-8/bone morphogenetic protein 2(BMP-2)ransforming growth factorβ(TGF-β)was analyzed.The diversity of the intestinal microbiota in KOA rats was analyzed via 16S ribosomal DNA(rDNA)sequencing.After fecal microbiota transplantation(FMT),which was induced by TENS,the improvement in the intestinal microbiota in KOA rats was analyzed.Results:After 3 weeks of treatment using TENS,compared to those in the model control group,the biomechanical parameters increased in the SH and TENS groups(p<0.05);the gait parameters improved in the SH and TENS groups;the bone mineral density(BMD)increased in the TENS group(p<0.05);the Mankin scores of the distal femur and proximal tibiofibular muscles decreased in the SH and TENS groups(p<0.05).IL-1β/6/8 expression levels decreased in the SH and TENS groups(p<0.05).BMP-2/TGF-βexpression in the distal femur increased in the TENS group(p<0.05).16S rDNA sequencing revealed that the intestinal microbiota of KOA rats was changed after TENS treatment,including increases in Escherichia-Shigella,Lachnospira,Eubacterium,Gastranaerophilales,and Rikenellaceae RC9 and decreases in Fusicatenibacter and Mycoplasma.After FMT,which is induced by TENS,similar improvements in KOA rats were obtained.Conclusions:TENS promoted anti-inflammatory and osteogenic effects by downregulating the Il-1β/6/8 expression levels and upregulating the BMP-2/TGF-βsignaling pathway.16S rDNA sequencing revealed that the intestinal microbiota of KOA rats was changed after TENS treatment via the gut–knee joint axis,and that these dominant genera of FMT elicited improvements in KOA rats.TENS caused improvements in KOA rats by regulating the intestinal microbiota;thus,TENS and induced FMT altered intestinal microbiota suggest a potential novel therapeutic avenue for KOA in clinical settings. 展开更多
关键词 fecal microbiota transplantation intestinal microbiota knee osteoarthritis transcutaneous electrical nerve stimulation
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Sphenopalatine ganglion stimulation:Clinical applications and innovative development 认领 引用
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作者 Ling-li QIN Yue GAO +5 位作者 Jian-wu SHEN Ran LUO Dian CHEN Wan-ying XIA Jin-sheng YANG Lu ZHANG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第1期61-66,共6页
The sphenopalatine ganglion(SPG)is a critical parasympathetic ganglion located beneath the maxillary nerves.Its anatomical structure and function play key roles in the regulation of cerebral blood vessels,the autonomi... The sphenopalatine ganglion(SPG)is a critical parasympathetic ganglion located beneath the maxillary nerves.Its anatomical structure and function play key roles in the regulation of cerebral blood vessels,the autonomic nervous system,and various headache-related disorders.In recent years,SPG stimulation(SPGS)has been widely applied in both invasive and acupuncture-mediated clinical practice.This paper outlines the current clinical applications of SPGS in treating conditions such as headaches,strokes,and rhinitis,and explores how innovative technologies,including ultrasound-guided techniques and singleuse sterile electrode acupuncture needles,may enhance therapeutic efficacy.The potential future development of SPGS in the field of neuromodulation is also discussed. 展开更多
关键词 Sphenopalatine ganglion Sphenopalatine ganglion stimulation technology Neuromodulation Single-use sterile electrode acupuncture needle
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Deep brain stimulation for the treatment of Alzheimer's disease:A safer and more effective strategy 认领 引用
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作者 Fan Zhang Yao Meng Wei Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1899-1909,共11页
Alzheimer's disease is the most common type of cognitive disorder,and there is an urgent need to develop more effective,targeted and safer therapies for patients with this condition.Deep brain stimulation is an in... Alzheimer's disease is the most common type of cognitive disorder,and there is an urgent need to develop more effective,targeted and safer therapies for patients with this condition.Deep brain stimulation is an invasive surgical treatment that modulates abnormal neural activity by implanting electrodes into specific brain areas followed by electrical stimulation.As an emerging therapeutic approach,deep brain stimulation shows significant promise as a potential new therapy for Alzheimer's disease.Here,we review the potential mechanisms and therapeutic effects of deep brain stimulation in the treatment of Alzheimer's disease based on existing clinical and basic research.In clinical studies,the most commonly targeted sites include the fornix,the nucleus basalis of Meynert,and the ventral capsule/ventral striatum.Basic research has found that the most frequently targeted areas include the fornix,nucleus basalis of Meynert,hippocampus,entorhinal cortex,and rostral intralaminar thalamic nucleus.All of these individual targets exhibit therapeutic potential for patients with Alzheimer's disease and associated mechanisms of action have been investigated.Deep brain stimulation may exert therapeutic effects on Alzheimer's disease through various mechanisms,including reducing the deposition of amyloid-β,activation of the cholinergic system,increasing the levels of neurotrophic factors,enhancing synaptic activity and plasticity,promoting neurogenesis,and improving glucose metabolism.Currently,clinical trials investigating deep brain stimulation for Alzheimer's disease remain insufficient.In the future,it is essential to focus on translating preclinical mechanisms into clinical trials.Furthermore,consecutive follow-up studies are needed to evaluate the long-term safety and efficacy of deep brain stimulation for Alzheimer's disease,including cognitive function,neuropsychiatric symptoms,quality of life and changes in Alzheimer's disease biomarkers.Researchers must also prioritize the initiation of multi-center clinical trials of deep brain stimulation with large sample sizes and target earlier therapeutic windows,such as the prodromal and even the preclinical stages of Alzheimer's disease.Adopting these approaches will permit the efficient exploration of more effective and safer deep brain stimulation therapies for patients with Alzheimer's disease. 展开更多
关键词 Alzheimer's disease amyloid-β cholinergic system deep brain stimulation entorhinal cortex fornix hippocampus mechanisms nucleus basalis of Meynert therapy
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Connotation,key issues,and future development of the new-generation volume stimulation technology 认领 引用
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作者 XU Yun WENG Dingwei +8 位作者 MA Zeyuan LI Deqi CAI Bo CHEN Ming YI Xinbin FU Haifeng YANG Zhanwei LI Shuai JIANG Hao 《Petroleum Exploration and Development》 SCIE 2026年第2期512-533,共22页
This paper systematically reviews the development history and generational characteristics of multi-stage fracturing technology in horizontal wells and defines the connotation and essence of the new-generation volume ... This paper systematically reviews the development history and generational characteristics of multi-stage fracturing technology in horizontal wells and defines the connotation and essence of the new-generation volume stimulation technology,as represented by eXtreme Limited Entry(XLE).The research indicates that classical fracturing theory remains the cornerstone for optimizing stimulation designs.Optimization based on fracture units is fundamental for achieving “perfect fracturing”,while “proppant loading intensity” serves merely as a statistical parameter and therefore cannot be used to evaluate fracturing effectiveness.Consequently,expanding the stimulated volume is identified as the key to achieving optimal stimulation results.Regarding limited entry perforation strategies,the study clarifies that all clusters initiation can be achieved when the total perforation friction exceeds the horizontal in-situ stress difference among clusters.Furthermore,XLE requires a total perforation friction greater than 10 MPa,superimposed on the treating pressure at wellhead after all clusters initiation,to ensure even fluid distribution across all fractures.Based on the characteristics of “fracture swarms” observed in cores from hydraulic fracturing test sites(HFTS),it is revealed that creating a single principal fracture is critical for effective fracture propagation.Drawing on the rheological characteristics of proppant settling in slickwater and learnings from North American HFTSs,three novel viewpoints on modern fracturing are proposed:Slickwater fracturing relies on velocity for proppant transport,and subsequently injected proppant travels the furthest,suggesting that “CounterProp” is the future direction of fracturing technology;High-viscosity slickwater struggles to achieve effective proppant transport;The proppant settling mode determines that the dynamic fracture width during the treatment is effectively equal to the propped fracture width.Finally,the technical connotation and implementation pathway for “whole-domain propped” treatment are presented,and a future development vision for Autonomous Intelligent Fracturing(AIF) is proposed. 展开更多
关键词 volume stimulation extreme limited entry fracture-controlled reservoir close cutting full-domain propping perfect fracturing gas suspension CounterProp propped fracture width
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Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression:A Quantitative Insomnia Sleep Inventory monitoring evaluation 认领 引用
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作者 Ai-Ming Gu Chao Liu +3 位作者 Jian-Hong Chen Ru-Ya Guo Chao Liang Xing-Shi Chen 《World Journal of Psychiatry》 SCIE 2026年第3期110-117,共8页
BACKGROUND Jiaxing Hospital of Traditional Chinese Medicine introduced transcranial magnetic stimulation(TMS)technology in 2019.In practical application,it was found that different types of equipment and technical par... BACKGROUND Jiaxing Hospital of Traditional Chinese Medicine introduced transcranial magnetic stimulation(TMS)technology in 2019.In practical application,it was found that different types of equipment and technical parameters could lead to differences in therapeutic effects.Therefore,our hospital selected a Danish-made TMS device,which ranked second in the Chinese market,and conducted tests on Gu AM et al.rTMS for PSD rehab http://gffzz4205af39ffde493esp5nbqkfwpc5w650o.ffgz.tsg.suse.edu.cn/10.5498/wjp.v16.i3.1160942 March 19,2026 Volume 16 Issue 3 patients with post-stroke depression(PSD)from March 2019 to September 2023.Before the test,a plan was formulated based on the quality status before and after the inspection.Two evaluators independently controlled the quality of the plan.The repetitive TMS(rTMS)and Quantitative Insomnia Sleep Inventory(QUISI)data were separately stored and verified independently by the two evaluators.AIM To investigate the effect of rTMS and QUISI on the sleep and rehabilitation of patients with PSD.METHODS From March 2019 to December 2023,subjects who were admitted to the Department of Rehabilitation of the Jiaxing Hospital of Traditional Chinese Medicine,Shanghai Mental Health Center,and National Medical Centre for Psychiatric Disorders were enrolled.A total of 108 patients with PSD were enrolled:54 patients in the observation group and 54 in the control group.Sixty-eight normal volunteers were also included.Both the observation group and the control group received venlafaxine 150 mg/day sustained-release therapy.The observation group was given venlafaxine combined with rTMS.The control group was treated with venlafaxine combined with rTMS pseudo stimulation.The two groups underwent 42 treatment sessions over 14 weeks.The Hamilton Depression Rating Scale-17 scores were compared between the two groups before and after treatment,and the changes in QUISI were compared with healthy volunteers.RESULTS The Hamilton Depression Rating Scale-17 scores in the two groups were significantly reduced after treatment,and the improvement was more significant in the observation group(P<0.05).Before treatment,the sleep latency in the two groups of patients by QUISI was delayed compared to normal volunteers,and the sleep efficiency and maintenance rate were lower than those in normal volunteers,with statistical significance(P<0.05-0.01).After 14 weeks of treatment,the sleep latency period in the observation group QUISI shifted forward,indicating an increase in sleep efficiency and maintenance rate.The differences between the observation group and the control group were statistically significant(P<0.01).After a 3-month rehabilitation evaluation,the total effective rate of patients in the observation group was significantly higher than that in the control group(P<0.05).CONCLUSION rTMS treatment has a positive effect on PSD in clinical practice.QUISI monitoring can be used for rehabilitation assessment. 展开更多
关键词 Post-stroke depression Repetitive transcranial magnetic stimulation Quantitative Insomnia Sleep Inventory monitoring Evaluation of rehabilitation Clinical study
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Trans-spinal magnetic stimulation upregulates microglial SOCS3 to attenuate neuroinflammation in chronic constriction injury-induced neuropathic pain 认领 引用
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作者 Qi Wu Xingjun Xu +10 位作者 Chenyuan Zhai Jili Cai Zun Wang Lu Fang Yu Wang Yilun Qian Manyu Dong Liang Hu Tong Wang Ying Shen Wentao Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第7期3092-3102,共11页
Current treatments for neuropathic pain are suboptimal,necessitating the search for more effective therapeutics.Our previous study showed that inhibition of neuroinflammation in the spinal cord induced analgesic effec... Current treatments for neuropathic pain are suboptimal,necessitating the search for more effective therapeutics.Our previous study showed that inhibition of neuroinflammation in the spinal cord induced analgesic effects,and focal repetitive trans-spinal magnetic stimulation showed an anti-neuroinflammatory effect in spinal cord injury rat models.Here,we speculated that repetitive trans-spinal magnetic stimulation might induce an anti-inflammatory effect to alleviate neuropathic pain by upregulating calmodulin-dependent protein kinase kinase beta(CaMKKβ)/adenosine 5′-monophosphate-activated protein kinase(AMPK)/suppressor of cytokine signaling-3(SOCS3)signaling in microglia.Experiments have found that non-invasive focal repetitive trans-spinal magnetic stimulation effectively alleviates mechanical allodynia and spinal neuroinflammation in rats with neuropathic pain induced by chronic sciatic nerve ligation.Further research found that repetitive trans-spinal magnetic stimulation upregulated the expression of SOCS3 in spinal microglia,which subsequently inhibited the phosphorylation of p38 mitogen-activated protein kinase and signal transducer and activator of transcription 3 and nuclear factor-kappa B p65 nuclear translocation in rats with neuropathic pain,thereby suppressing neuroinflammation.The upregulation of SOCS3 by repetitive trans-spinal magnetic stimulation may be achieved through the activation of the CaMKKβ/AMPK signaling pathway in microglia.The results suggested that focal repetitive trans-spinal magnetic stimulation inhibits spinal neuroinflammation and alleviates neuropathic pain by activating the CaMKKβ/AMPK/SOCS3 signaling pathway in spinal microglia.This mechanism provides an effective noninvasive treatment for neuropathic pain caused by peripheral nerve injury. 展开更多
关键词 CaMKKβ/AMPK/SOCS3 signaling chronic constriction injury mechanical pain sensitivity microglia neuropathic pain neuroinflammation nuclear factor-κB p65 repetitive trans-spinal magnetic stimulation STAT3
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Further insights into the efficacy and moderators of transcranial alternating current stimulation for working memory 认领 引用
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作者 Haewon Byeon 《World Journal of Psychiatry》 SCIE 2026年第2期409-413,共5页
This letter offers a critical appraisal of the systematic review and meta-analysis by Hou et al,which examined the effect of theta-band transcranial alternating current stimulation(theta-tACS)on working memory in heal... This letter offers a critical appraisal of the systematic review and meta-analysis by Hou et al,which examined the effect of theta-band transcranial alternating current stimulation(theta-tACS)on working memory in healthy adults.The authors initially reported a moderate,statistically significant enhancement of working memory performance(Hedges’g=0.405),although this effect became nonsignificant following adjustment for publication bias.This commentary highlights key strengths of the meta-analysis,including its targeted focus on a frequency band theoretically relevant to working memory,comprehensive moderator analyses,and task-specific subgroup comparisons(N-back vs delayed match-tosample).At the same time,it emphasizes the substantial impact of publication bias,the considerable heterogeneity among included studies,and the unexpected finding that fixed-frequency stimulation protocols outperformed individualized approaches.While uncertainty remains regarding the overall efficacy of thetatACS,the observed task-specific improvements in N-back performance and the identification of critical stimulation parameters(such as frequency,duration,and stimulation timing relative to task performance)offer valuable direction for protocol refinement.Taken together,this meta-analysis provides an important and cautionary synthesis that reinforces the need for pre-registered,methodologically rigorous studies to establish the cognitive and potential clinical benefits of thetatACS with greater confidence. 展开更多
关键词 Theta-band transcranial alternating current stimulation Working memory Meta-analysis Publication bias N-back task
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Neuromodulation techniques for modulating cognitive function:Enhancing stimulation precision and intervention effects 认领 引用 被引量：1
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作者 Hanwen Cao Li Shang +9 位作者 Deheng Hu Jianbing Huang Yu Wang Ming Li Yilin Song Qianzi Yang Yan Luo Ying Wang Xinxia Cai Juntao Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第2期491-501,共11页
Neuromodulation techniques effectively intervene in cognitive function,holding considerable scientific and practical value in fields such as aerospace,medicine,life sciences,and brain research.These techniques utilize... Neuromodulation techniques effectively intervene in cognitive function,holding considerable scientific and practical value in fields such as aerospace,medicine,life sciences,and brain research.These techniques utilize electrical stimulation to directly or indirectly target specific brain regions,modulating neural activity and influencing broader brain networks,thereby regulating cognitive function.Regulating cognitive function involves an understanding of aspects such as perception,learning and memory,attention,spatial cognition,and physical function.To enhance the application of cognitive regulation in the general population,this paper reviews recent publications from the Web of Science to assess the advancements and challenges of invasive and non-invasive stimulation methods in modulating cognitive functions.This review covers various neuromodulation techniques for cognitive intervention,including deep brain stimulation,vagus nerve stimulation,and invasive methods using microelectrode arrays.The non-invasive techniques discussed include transcranial magnetic stimulation,transcranial direct current stimulation,transcranial alternating current stimulation,transcutaneous electrical acupoint stimulation,and time interference stimulation for activating deep targets.Invasive stimulation methods,which are ideal for studying the pathogenesis of neurological diseases,tend to cause greater trauma and have been less researched in the context of cognitive function regulation.Non-invasive methods,particularly newer transcranial stimulation techniques,are gentler and more appropriate for regulating cognitive functions in the general population.These include transcutaneous acupoint electrical stimulation using acupoints and time interference methods for activating deep targets.This paper also discusses current technical challenges and potential future breakthroughs in neuromodulation technology.It is recommended that neuromodulation techniques be combined with neural detection methods to better assess their effects and improve the accuracy of non-invasive neuromodulation.Additionally,researching closed-loop feedback neuromodulation methods is identified as a promising direction for future development. 展开更多
关键词 acupuncture points attention brain cognition efficiency electrical stimulation microelectrodes movement disorders nervous system perception
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Integrative acupoint stimulation within enhanced recovery after endoscopic procedures:Harnessing the neuroimmune axis for enhanced gastrointestinal recovery 认领 引用 被引量：2
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作者 Gang Wang Sheng-Jie Pan 《World Journal of Gastroenterology》 SCIE CAS 2026年第3期1-6,共6页
Enhanced recovery after surgery(ERAS)programs have transformed perioperative care,yet delayed gastrointestinal function and excessive neuroendocrine stress remain major obstacles to optimal recovery.Hong et al’s rand... Enhanced recovery after surgery(ERAS)programs have transformed perioperative care,yet delayed gastrointestinal function and excessive neuroendocrine stress remain major obstacles to optimal recovery.Hong et al’s randomized controlled trial embedded acupoint-based neuromodulation-meridian-timed acupoint application combined with transcutaneous electrical acupoint stimulation-within an ERAS framework and demonstrated accelerated gastrointestinal recovery accompanied by endocrine attenuation.This article offers a structured critical appraisal of the trial,emphasizing methodological rigor,mechanistic plausibility,and alignment with ERAS core principles of stress mitigation,functional restoration,and patient experience.The observed reductions in norepinephrine,cortisol,and aldosterone suggest modulation of the hypothalamic-pituitary-adrenal axis as a key mediator of benefit.Future research priorities include multicenter,sham-controlled validation;integration of autonomic and inflammatory biomarkers(heart rate variability,interleukin-6,tumor necrosis factor-α,C-reactive protein);and pragmatic evaluation of cost-effectiveness and acceptability.Positioning acupoint stimulation within precision-integrative perioperative care could advance ERAS from a recovery protocol to a system of host-response modulation.Integrative acupoint neuromodulation thus represents a biologically coherent,low-risk,and scalable strategy for enhancing resilience,accelerating gastrointestinal recovery,and improving surgical outcomes worldwide. 展开更多
关键词 Enhanced recovery after surgery Acupoint stimulation Gastrointestinal
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Beyond the surface:Advancing neurorehabilitation with transcranial temporal interference stimulation——clinical applications and future prospects 认领 引用 被引量：1
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作者 Camille E.Proulx Friedhelm C.Hummel 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1987-1988,共2页
Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despit... Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despite differences in the mechanisms of injury,both conditions share a high prevalence of motor and cognitive impairments.These deficits show only limited natural recovery. 展开更多
关键词 neurorehabilitation stimulation transcranial temporal interference motor cognitive impairments brain lesionssuch motor cognitive impairmentsthese
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