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A National Follow-up Study on the Effect of Health Protective Factors on Frailty Transition among Older Adults in China 认领 引用 被引量：1
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作者 Jing Shi Ziyi Zhou +12 位作者 Baiyu Zhou Yongkang Tao Yan Cen Luyao Zhang Sainan Li Ying Li Botao Sang Xiangfei Liu Qinan Ma Xuezhai Zeng Pulin Yu Jing Li Deping Liu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第3期270-284,共15页
Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective fact... Objective Frailty is becoming increasingly common among aging adults.Frailty transitionis shaped by biological,social,psychological,and environmental factors.This study investigated combined effects of protective factors on frailty transition by constructing a Protection Index(PI)to guide targeted interventions.Methods Data were extracted from the 4th Sample Survey of the Aged Population in Urban and Rural China,including baseline(2017)and follow-up(2019)surveys.Frailty was assessed using the Frailty Index(FI),whereas the PI measured protective factors.Frailty transitions over 2 years were analyzed prospectively.Pearson’s correlation examined the relationship between FI and PI,and logistic regression assessed the effects of PI on frailty transitions.Results This study included 9,093 older adults.FI values increased with age and were higher in women,whereas PI values decreased with age and were higher in men.Over 2 years,56.2%of the participants showed a stable frailty status,14.2%improved,and 29.6%worsened.Negative transitions were more common than positive transitions,with transitions occurring most frequently between adjacent states.The PI was moderately negatively correlated with the FI(r=−0.349,P<0.001).A higher PI was associated with a lower risk of negative transitions among robust and prefrail individuals(OR=0.989,0.981,both P<0.05),but showed no significant effect among those with existing frailty.Conclusion Negative frailty transitions were more common with advancing age.Enhancing PI may help prevent negative frailty transitions among robust and pre-frail older adults,underscoring the value of early interventions. 展开更多
关键词 Frailty transition Frailty Older adults Protective factors Follow-up study National survey
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Association between Dietary Diversity during Pregnancy and Gestational Diabetes Mellitus:A Prospective Cohort Study 认领 引用 被引量：1
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作者 Weiming Wang Qian Liang +5 位作者 Jin Liu Chenfan Zhang Yuhui Luo Xuefeng Yang Liping Hao Nianhong Yang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期418-426,共9页
Objective The study aims to prospectively examine the association between the minimum dietary diversity for women(MDD-W)score and risk of gestational diabetes mellitus(GDM).Methods All participants were pregnant women... Objective The study aims to prospectively examine the association between the minimum dietary diversity for women(MDD-W)score and risk of gestational diabetes mellitus(GDM).Methods All participants were pregnant women enrolled in the Tongji Maternal and Child Health Cohort.Dietary intake was assessed using a food frequency questionnaire(FFQ)or 24-h dietary recall.The MDD-W score was constructed by categorizing all food items into 10 food groups,following the Food and Agriculture Organization guidelines.Oral glucose tolerance tests(OGTT)were conducted during 24−28 weeks of gestation to screen for GDM.Poisson regression models were used to assess the association between MDD-W scores and GDM risk.Results In total,357(11.8%)of the 3,026 women were diagnosed with GDM.Compared with participants whose MDD-W score was≥8,those with a score of 5−7 had an increased risk of GDM(relative risk(RR):1.32;95%confidence interval(CI):1.03,1.69),and those with a score≤4 had a significantly higher GDM risk(RR:1.58;95%CI:1.12,2.26).Furthermore,these findings indicate that pregnant women with MDD-W scores<8,in conjunction with being overweight or obese before pregnancy and excessive gestational weight gain,have the highest risk of developing GDM.Conclusions These data suggest that a higher MDD-W score during pregnancy is independently associated with a lower GDM risk.Therefore,promoting dietary diversity and weight management is recommended to protect pregnant women from developing gestational diabetes. 展开更多
关键词 Dietary diversity Gestational diabetes mellitus Pregnant women Cohort study
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Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study 认领 引用 被引量：1
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作者 FENG Sisi XIAO Xiaomin +2 位作者 ZHOU Manli HUANG Zixin ZHONG Baiyun 《中南大学学报（医学版）》 CAS CSCD 北大核心 2026年第1期118-128,共11页
Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrat... Objective:The incidence and mortality of colorectal carcinoma(CRC)continue to rise globally,highlighting the need to identify modifiable risk factors for early detection and prevention.Previous studies have demonstrated significant associations between CRC risk and various serum metabolites as well as inflammatory cytokines;however,due to limitations in study design and potential confounding factors,the causal relationships remain unclear.This study aims to investigate the causal relationships between inflammatory cytokines,serum metabolites,and CRC risk,providing a theoretical basis for the development of novel early diagnostic biomarkers and therapeutic targets.Methods:A two-sample Mendelian randomization(MR)design was applied using summary statistics from genome-wide association studies(GWAS).Instrumental variables(IVs)were derived from:1)metabolomics GWAS data of 1400 serum metabolites(n=8299);2)cytokine GWAS data of 91 inflammatory factors(n=14824);and 3)CRC risk data from the FinnGen consortium(6847 cases and 314193 controls).The primary analysis was conducted using the inverse-variance weighted(IVW)method,with sensitivity analyses performed using MR Egger regression and the weighted median method.Effect estimates including odds ratios(OR),95%confidence intervals(CI),and false discovery rates(FDR)were calculated.Results:MR analysis indicated that higher levels of axin-1(AXIN1)(OR=0.84195%CI 0.714 to 0.991)and Fms-related tyrosine kinase 3 ligand(Flt3L)(OR=0.916,95%CI 0.844 to 0.994)were associated with a reduced risk of CRC.In contrast,higher levels of Delta/Notchlike epidermal growth factor-related receptor(DNER)(OR=1.119,95%CI 1.009 to 1.241)and vascular endothelial growth factor A(VEGF-A)(OR=1.078,95%CI 1.011 to 1.150)were associated with an increased risk of CRC(all P<0.05).Metabolomics association analysis further identified 144 serum metabolites significantly correlated with these four key inflammatory cytokines(FDR<0.05),suggesting that they may regulate CRC risk through inflammatory pathways.Conclusion:Specific inflammatory cytokines and serum metabolites have causal relationships with the risk of CRC.These findings provide insights for further exploration of potential risk factors and the development of effective prevention strategies for CRC. 展开更多
关键词 inflammatory cytokines serum metabolites colorectal carcinoma Mendelian randomization genome-wide association study metabolomics analysis
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders:a genome-wide association study and multi-ancestry validation in schizophrenia 认领 引用 被引量：1
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作者 Zhe Lu Yao-Yao Sun +5 位作者 Zhe-Wei Kang Guo-Rui Zhao Yu-Yanan Zhang Jun-Yuan Sun Rui Yuan Wei-Hua Yue 《Military Medical Research》 SCIE CAS CSCD 2026年第2期185-197,共13页
Background:Antipsychotic-induced movement disorders(AIMDs)are prevalent side effects of antipsychotics,particularly during the acute phase of treatment.This study aimed to elucidate the genetic mechanisms underlying A... Background:Antipsychotic-induced movement disorders(AIMDs)are prevalent side effects of antipsychotics,particularly during the acute phase of treatment.This study aimed to elucidate the genetic mechanisms underlying AIMDs using a genome-wide association study(GWAS).Methods:GWASs on AIMDs were conducted in three independent cohorts:a discovery cohort of 3067 patients(2016 subjects were reserved after quality control),a validation cohort of 277 patients,and a multi-ancestry validation cohort of 766 patients.Subsequent post-GWAS analyses included gene-based analyses,transcriptome-wide association studies(TWASs),and polygenic risk score(PRS)profiling.Results:Our study identified two loci located in RAB44 gene(rs116249243,P=5.98×10-9;rs117097482,P=1.17×10-8)associated with extrapyramidal symptoms(EPSs),1 locus(rs6826172,P=5.56×10-9)related to akathisia,and 76 loci linked to involuntary movements(11 genes were mapped).Risk loci located in CNTNAP2,LUZP2,TMEM167A,and RAB44 genes were successfully replicated in the validation cohort,whereas the locus located in RAB44 was also replicated in the multi-ancestry cohort.Gene-based analyses indicated that XRCC4 and PAIP2B reached significance at the genome-wide level in involuntary movements.Tissue expression analysis revealed that involuntary movement-related genes are predominantly expressed in the substantia nigra.Additionally,the TWAS suggested a causal relationship between XRCC4 and involuntary movement.The PRSs derived from the discovery cohort significantly predicted AIMDs in the validation cohort,with area under the receiver operating characteristic curve(AUC)values from 0.60 to 0.80.Conclusions:Our findings highlight the role of substantia nigra related gene polymorphisms in AIMDs.This study provides novel insights into the pathogenesis of AIMDs and supports the potential for personalized treatment approaches for schizophrenia. 展开更多
关键词 Antipsychotic Movement disorders Genome-wide association study(GWAS) Substantia nigra Multiancestry validation
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Compound Temperature–humidity Extremes Increase Acute Mental Health Outcomes:A 12-year Case-crossover Metropolitan Study 认领 引用
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作者 Xin Liu Xin Huang +8 位作者 Jingya Zhang Haoran Li Ning Zhang Yingying Su Yang Wang Tongyan Liu Rengyu Wu Jincai Wei Bin Zhu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第4期493-498,共6页
Mental disorders(MDs)significantly impair cognition,mood,and social behavior,ranking among the top 10 leading causes of the global disease burden.Rising ambient temperatures are a critical factor triggering mental hea... Mental disorders(MDs)significantly impair cognition,mood,and social behavior,ranking among the top 10 leading causes of the global disease burden.Rising ambient temperatures are a critical factor triggering mental health-related conditions[1],especially under extreme temperature conditions[2].Humidity further exacerbates these effects by inhibiting sweating and intensifying heat stress,making it a significant contributor to heat-related mental health impacts[3].Existing evidence highlights an elevated risk of MDs associated with the combined effects of temperature and humidity[3,4].However,current research lacks a comprehensive analysis of these combined effects on mental health. 展开更多
关键词 mental disorders cognition metropolitan study temperature case crossover mental disorders mds significantly humidity mental health
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Effectiveness of Xuanbai Shengmai Decoction,a compound Chinese herbal medicine,on disease progress and viral RNA shedding in COVID-19 patients:A retrospective study of medical chart in China 认领 引用
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作者 Teng-wen Liu Shu-wen Zhang +15 位作者 Hui Jiang Si-wen Yang Yi-jia Guo Mao-yu Ding Xu-cheng Li Jia Xu Hai-tian Lu Hao-ran Ye Ya-hui Hu Rui Li Yi-ming Wei Mai-fen Song Shuo Wang Jun Zhang Quan-sheng Feng Xiao-long Xu 《Journal of Integrative Medicine》 SCIE CAS CSCD 2026年第1期115-124,共10页
Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods... Objective:To describe the clinical features and effectiveness of Xuanbai Shengmai Decoction(XB,a compound Chinese herbal medicine)on disease progression,clinical effect and viral RNA shedding in COVID-19 cases.Methods:We collected demographic and clinical information of 212 COVID-19 cases from December2022 to January 2023,and divided these cases into two groups based on whether XB was used or not.Survival curves in the two groups were estimated by the Kaplan-Meier method.A smoothing approximation of time-to-event distributions was created based on a log-rank test and a restricted mean survival time model,and the Gaussian density estimation method.In addition,the effect of XB treatment on survival time was assessed using a series of Cox proportional hazards models.Results:Of all 212 COVID-19 cases,there were respectively 63 and 149 cases reported in XB group and non-XB group.Of those,128(60.4%)were male,with median age of 75.00 years,and 72.6%had one or more underlying medical conditions.The most common symptoms on admission were cough(64.6%),fever(39.6%),wheezing(27.8%)and sputum(13.2%).In addition,the gender,age group distribution,smoking,and drinking between two groups were of no significant difference(P>0.05).However,the clinical characteristics and CT findings in XB group were more serious than those in non-XB group.Nevertheless,the hazard of death in XB group was lower than that in non-XB group,especially on severe cases.Treatment with XB significantly protected against adverse outcomes,shorten the time of viral RNA shedding.Moreover,interventional therapy of XB within 1–2 days after hospital admission is confirmed with particularly effectiveness.Conclusion:Treatment of XB is effective for COVID-19 cases,particularly in reducing the mortality rate of severe cases,suggesting that XB may be used as an alternative treatment of SARS-COV-2 infection. 展开更多
关键词 COVID-19 Severe case Traditional Chinese medicine Retrospective study Mortality RNA shedding
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Genome-wide association study reveals genomic regions for nitrogen,phosphorus and potassium use efficiency in bread wheat 认领 引用
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作者 Jili Xu Shuo Liu +4 位作者 Zhiyuan Gao Qingdong Zeng Xiaowen Zhang Dejun Han Hui Tian 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第3期847-863,共17页
The development of wheat cultivars with improved nitrogen(N),phosphorus(P),and potassium(K)use efficiency is essential for sustainable agriculture.Genetic dissection and identification of causative genes underlying nu... The development of wheat cultivars with improved nitrogen(N),phosphorus(P),and potassium(K)use efficiency is essential for sustainable agriculture.Genetic dissection and identification of causative genes underlying nutrient use efficiency represent a key strategy toward this goal.We conducted an extensive genome-wide association study(GWAS)using a panel of 431 wheat cultivars,identifying 1,659 significant single-nucleotide polymorphisms(SNPs)(LOD>5)through genotyping-by-sequencing.This analysis revealed 534 quantitative trait loci(QTLs)associated with 12 nutrient use efficiency traits across five distinct environments,among which 14 QTLs were consistently detected in at least three environments.Notably,meta-QTL analysis,showed that QTL80(72.12–74.24 Mb,chr2A),QTL387(32.88–33.56 Mb,chr6A),and QTL500(535.53–540.80 Mb,chr7B)exhibit clear co-localization with MQTL-2A-2,MQTL-6A-1,and MQTL-7B-2,respectively.This overlap highlights their robustness across diverse environmental conditions.Within these regions,critical candidate genes-including members of the bZIP transcription factor family and a potassium transporter gene-were identified in relation to nutrient use efficiency.Furthermore,a novel locus,QTL234,was discovered,harboring key candidate genes such as dof zinc finger protein,Ankyrin repeat family protein,and cytochrome P450.To validate the SNP within QTL234 associated with nitrogen harvest index(NHI),we developed a dCAPS marker for AX-109095537.These findings demonstrate the effectiveness of high-resolution SNP-based GWAS in rapidly pinpointing promising candidate genes.They also establish a foundation for large-scale QTL fine mapping,candidate gene validation,and the development of functional markers essential for enhancing nutrient use efficiency in wheat breeding programs. 展开更多
关键词 wheat genome-wide association study nutrient use efficiency meta-QTL analysis candidate genes
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Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus 认领 引用
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作者 Hong-Ping Yu Bang-De Xiang +29 位作者 Ji Qian Hongliang Liu Yuan-Feng Li Qiuling Lin Shun Liu Junjie Wei Shicheng Zhan Binbin Jiang Juncheng Dai Liang Ma Litu Zhang Yingchun Liu Qiuping Wen Wenfeng Gong Shengping Li Yanji Jiang Ji Zheng Tianyi Zhu Zihan Zhou Xiaoyun Zeng Ziliang Wang Ji-Ao Wang Rui Guo Yuan Yang Qingyi Wei Gangqiao Zhou Xiao-Qiang Qiu Weizhong Tang Mengyun Wang Ruoxin Zhang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第4期643-654,共12页
Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.A... Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide.Hepatocellular carcinoma(HCC)is the primary histological subtype,and hepatitis B virus(HBV)carriers have a higher risk of HCC.Although several susceptibility loci for HCC have been identified in East Asian populations through genome-wide association studies(GWAS),the underlying biological mechanisms of this malignancy remain incompletely understood.Here,we conduct a two-stage GWAS including 2413 cases and 2794 HBV-positive controls from a high-incidence region in Southern China.The function of the susceptibility locus is investigated by bioinformatic and experimental approaches,supported by a xenograft model.We identify a 4p14 locus significantly associated with the risk of HCC(rs55718051,OR[95%CI]=0.73[0.67-0.80],Pmeta=9.14×10-11),and 18q23 locus with borderline significance(rs12964643:OR[95%CI]=0.75[0.67-0.83],Pmeta=1.11×10-7).Functional experiments indicate the role of rs55718051 in FAM114A1 expression regulation,possibly through the interaction with FOXA1.Knockdown of FAM114A1 significantly promote the oncogenic phenotypes in liver cancer cells,suggesting its potential tumor suppressor role.Our findings expand the understanding of HCC susceptibility and suggest FAM114A1 as a potential suppressor in HBV-related HCC carcinogenesis. 展开更多
关键词 Hepatocellular carcinoma Hepatitis B virus Genome-wide association study Functional variant Cancer susceptibility
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Clinical characteristics of acupoint sensitization in patients with essential hypertension:a cross-sectional matched case-control study 认领 引用
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作者 GONG Yu HAO Xiaomin +2 位作者 LIU Qingguo TIAN Junjian LIU Yu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2026年第3期684-694,共11页
OBJECTIVE:To observe the characteristics of acupoint sensitization in patients with essential hypertension,analyze the mechanical pain threshold and tenderness threshold of each acupoint,and summarize the clinical cha... OBJECTIVE:To observe the characteristics of acupoint sensitization in patients with essential hypertension,analyze the mechanical pain threshold and tenderness threshold of each acupoint,and summarize the clinical characteristics of high-sensitivity acupoints.METHODS:This study employed a cross-sectional matched case-control design and enrolled a total of 448 volunteer participants,including 224 patients with hypertension and 224 healthy controls.The main outcome measures included measuring the mechanical pain threshold and tenderness threshold of 16 highly sensitive acupoints in both hypertensive subjects and healthy controls.The receiver operating characteristic curve method was used to evaluate the sensitivity of each acupoint.Additionally,the rules of mechanical pain threshold,tenderness threshold sensitization rate,and degree of sensitization of each acupoint in hypertension patients were summarized to identify the optimal highly sensitive acupoints related to hypertension.RESUITS:The mechanical pain threshold and tenderness threshold of hypertensive patients were significantly lower than those of healthy subjects,the difference was statistically significant(P<0.001),indicating that the mechanical pain threshold and tenderness threshold of hypertensive patients at various points had a downward trend.Acupoints with high incidence of sensitization in hypertensive patients include Quchi(LI11),Taichong(LR3),Fenglong(ST40),Xingjian(LR2),Taixi(KI3)and Renying(ST9).CONCLUSION:This study successfully achieved the objective of exploring acupoint sensitization in patients with primary hypertension.Hypertensive patients exhibited significantly lower mechanical pain thresholds and pressure pain thresholds compared to healthy subjects.These findings provide clinical evidence for acupoint selection in acupuncture treatment for primary hypertension. 展开更多
关键词 essential hypertension acupoint sensitization ROC analyses cross-sectional studies case-control studies
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Genome-wide association study of sucrose content and stem diameter in sugarcane(Saccharum spp.) 认领 引用
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作者 Fenggang Zan Zhuandi Wu +10 位作者 Chengcai Xia Long Zhao Qi Liu Zihao Wang Yanjie Lu Meiling Zou Yong Zhao Peifang Zhao Xuan Luo Jiayong Liu Zhiqiang Xia 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第5期1939-1948,共10页
Increasing the sucrose content of sugarcane,a major sugar crop,is a key breeding objective.However,the complex genetic background of sugarcane affects development of sugarcane hybrids.In this study,we sequenced 292 su... Increasing the sucrose content of sugarcane,a major sugar crop,is a key breeding objective.However,the complex genetic background of sugarcane affects development of sugarcane hybrids.In this study,we sequenced 292 sugarcane germplasm accessions and identified 2,542,965 single nucleotide polymorphisms(SNPs) and insertions/deletions(InDels).We performed a genome-wide association study(GWAS) for two important sugarcane traits:sucrose content and stem diameter.Both traits followed a normal distribution and showed typical characteristics of quantitative traits.Population structure analysis revealed four subpopulations with an average genetic distance of 0.236.GWAS of the sucrose content detected 27 SNPs.After annotating genes at or near significant loci,17 candidate genes were screened.For stem diameter,GWAS revealed 19 SNPs,from which 9 candidate genes were identified.These results improve our understanding of genetic mechanisms affecting sucrose content in sugarcane,and identify important genetic resources to accelerate breeding of new sugarcane varieties with high sucrose content. 展开更多
关键词 sugarcane sucrose content stem diameter genome-wide association study(GWAS)
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Genomic sequencing as a key primary recommendation for neonatal hyperbilirubinemia:a population-based multicenter study 认领 引用
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作者 Dabin Huang Xia Gu +10 位作者 Weizhong Li Hongying Mi Haiquan Zeng Guiying Zhuang Sitao Li Congcong Shi Tao Wei Wei Zhou Xin Xiao Wenhao Zhou Hu Hao 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第3期467-475,共9页
Genetic variations are risk factors for neonatal hyperbilirubinemia(NHB),a common cause of infant hospitalization in the first postnatal week,but their contribution and long-term impacts remain unclear.This population... Genetic variations are risk factors for neonatal hyperbilirubinemia(NHB),a common cause of infant hospitalization in the first postnatal week,but their contribution and long-term impacts remain unclear.This population-based multicenter study enrolls 1780 hospitalized NHB newborns and 38,158 genetically screened newborns across 20 hospitals(2019-2022).Excluding cases with clear clinical causes,977 NHB cases are categorized into genetic variation-positive and-negative groups.Results show significantly higher NHB-related gene variants(81.63%vs.65.62%)and positive variation rates(36.29%vs.9.4%)in NHB cases than in the general newborn population(all P<0.001).Among the 977 NHB cases,325(33.3%)have positive variants,with higher rates of severe hyperbilirubinemia(16.9%vs.9.7%,P=0.001),prolonged jaundice(36.3%vs.27.6%,P=0.005),and cholestasis/hypercholanaemia(23.7%vs.14.7%,P<0.001)in the positive group.Cumulative genetic variants in bilirubin metabolism pathways exhibit dosedependent associations with increased risks of complications.Long-term follow-up reveals that UGT1A1 variants prolong jaundice up to one month,while severe SLC10A1 variants cause persistent cholestasis/hypercholanaemia beyond nine months.This large-scale evidence highlights genetic factors as key NHB determinants,with implications for neonatal care protocols to integrate genetic testing and establish longterm surveillance for variant carriers. 展开更多
关键词 Neonatal hyperbilirubinemia Jaundice polygene metabolic disorder Genetic variations Prolonged jaundice Multicenter observational study
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A comprehensive study on huff-n-puff oil recovery in tight sedimentary tuff oil reservoirs 认领 引用
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作者 Shuai Li Hai Huang +7 位作者 Junbin Chen Shenglai Yang Ermeng Zhao Xinyuan Gao Bin Shen Yubo Liu Xiangrong Nie Zhiguo Wang 《International Journal of Coal Science & Technology》 SCIE EI CAS CSCD 2026年第1期333-357,共25页
Huff-n-puff(HnP)is currently an important means to enhance the oil recovery of tight oil reservoirs.In this study,taking tight sedimentary tuff oil reservoirs in Santanghu Basin,China as an example,the oil production ... Huff-n-puff(HnP)is currently an important means to enhance the oil recovery of tight oil reservoirs.In this study,taking tight sedimentary tuff oil reservoirs in Santanghu Basin,China as an example,the oil production law,pore utilization characteristics,and influencing factors of water,N2,CO2,N2 water alternating,and CO2 water alternating HnP(WHP,NHP,CHP,NWAHP,CWAHP)are comprehensively studied.The results show that middle pores(MPs)are the main pore utilization interval for various HnP mediums.The recovery rates(RRs)of five rounds of WHP,NHP,and CHP are 39.32%,44.45%,and 61.24%,with contribution rates(CRs)of MPs being 68.60%,47.87%,and 56.00%.The RRs and CRs of various pores are closely related to their pore distribution and the oil recovery mechanism of the medium.Under the experimental conditions of this study,the RR of CHP does not have an obvious rock sample size effect,with sweep depth exceeding 1.25 cm in each round.The RR of CHP is positively correlated with injection pressure and shut-in time,and the injection exceeding the rock fracture fracturing and 300 min shut-in time are recommended.The RRs of six rounds of NWAHP and CWAHP are 51.98% and 62.75%,with CRs of MPs being 60.39%and 58.32%.The oil recovery effect(ORE)of NWAHP is better than that of their individual,while the ORE of CWAHP is better than that of WHP but close to that of CHP.The alternating sequence affects the stage RR of NWAHP and CWAHP.The NWAHP and CWAHP have great advantages in improving RR,reducing injection cost,and stabilizing production,and are expected to achieve rapid development. 展开更多
关键词 Huff-n-puff oil recovery Tight sedimentary tuff oil reservoirs Single-medium Dual-medium alternating Comprehensive study
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Morphological Characteristics and Influencing Mechanisms of Traditional Tujia Villages from the Perspective of Spatial Genes:A Case Study of the Wuling Mountain Area,Southwest China 认领 引用
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作者 LIU Tianqi WANG Yunzhe +3 位作者 SUN Chang WU Zongshu XU Hui WANG Xu 《Chinese Geographical Science》 SCIE CAS CSCD 2026年第3期492-508,共17页
Traditional villages represent a concentrated expression of the preservation and transmission of traditional culture within the context of rural revitalization,conveying important social,historical,and cultural values... Traditional villages represent a concentrated expression of the preservation and transmission of traditional culture within the context of rural revitalization,conveying important social,historical,and cultural values.Based on the perspective of spatial genes,this study selected 67 typical traditional villages in the Wuling Mountain Area in Southwest China as the case study.Between 2021 and 2024,by identifying and extracting spatial genes through the semi-structured interviews,Laddering Technique,and Landscape Pattern Index,and applying the geo-detector,the study explored the morphological characteristics and influencing mechanisms of traditional Tujia villages from the perspective of spatial genes of ecological-production-living.The findings are as follows:1)the spatial genes of traditional Tujia villages in the Wuling Mountain Area exhibit distinct patterns.Ecological genes,categorized by natural environment and layout,demonstrate a transition from clustered to dispersed patterns from the southern to northern regions.Production genes,categorized by location and cultivation patterns,show concentrated agricultural lands in the south and fragmented in the north.Living genes,divided into house plans,facades,and public buildings,reveal a higher prevalence of courtyards,stilted houses,and public buildings in northern areas.2)The spatial genes have evolved through the combined influence of four key factors:natural environment,socioeconomic development,policy systems,and ethnic culture.3)The integration of multi-source data and the application of both qualitative and quantitative approaches provide a comprehensive framework for analyzing traditional village form and their influencing mechanisms.This methodology offers valuable insights for developing sustainable strategies for the conservation of traditional Tujia traditional villages in this region. 展开更多
关键词 village morphology village spatial genes mechanism study ecological-production-living spaces traditional Tujia village Wuling Mountain Area,China
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Residential greenness,air pollution,and incident age-related macular degeneration:A prospective cohort study 认领 引用
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作者 Jiali Wang Yinyan Gao +2 位作者 Yijuan Lin Irene X.Y.Wu Fang Xiao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第1期242-249,共8页
Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenn... Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NOx),particulate matter<2.5μm(PM2.5),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO2),1.09(1.03–1.15)for NOx,1.14(1.05–1.24)for PM2.5,1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO2,NOx,PM2.5 and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk. 展开更多
关键词 Age-related macular degeneration(AMD) Residential greenness Ambient air pollution Mediation effect Prospective cohort study
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Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome:A multicenter study 认领 引用
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作者 Mi Lv Xin Liu +4 位作者 Kai-Yue Huang Lu-Si Xu Hui Che Meng-Xi Yao Feng-Yun Wang 《World Journal of Gastroenterology》 SCIE CAS 2026年第28期66-77,共12页
BACKGROUND The overlap between non-erosive reflux disease(NERD)and epigastric pain syndrome(EPS)is common in China,but its clinical profile and healthcare burden are poorly defined.AIM To characterize patients with NE... BACKGROUND The overlap between non-erosive reflux disease(NERD)and epigastric pain syndrome(EPS)is common in China,but its clinical profile and healthcare burden are poorly defined.AIM To characterize patients with NERD-EPS overlap and identify factors linked to frequent gastroenterology clinic visits.METHODS In a multicenter,cross-sectional study,800 consecutive patients with NERD-EPS overlap were enrolled from four tertiary hospitals in China.Data were collected via questionnaires on socio-demographics,clinical manifestations,medication use,visit frequency,and psychological distress(4-item Patient Health Questionnaire).Multivariable ordinal logistic regression identified factors independently associated with higher visit frequency.RESULTS Among the 800 patients(mean age 44.50±14.43 years;66.70%female),42.40%had≥3 clinic visits.Independent risk factors for more frequent visits included older age[adjusted odds ratio(aOR)=1.02],longer NERD duration(aOR=1.004),higher psychological distress(aOR=1.08 per 1-point 4-item Patient Health Questionnaire increase),mixed labor(aOR=3.37)or physical labor(aOR=1.91),married status(aOR=2.05),proton pump inhibitor use(aOR=1.39),and Chinese herbal preparation use(aOR=6.64).A significant synergistic interaction on visit frequency was found between proton pump inhibitor and herbal use(interaction aOR=29.06,P<0.001).CONCLUSION Frequent outpatient visits in NERD-EPS overlap is driven by a combination of demographic factors,chronicity,psychological comorbidity,and complex medication patterns,rather than symptoms alone.These findings highlight the strong association between psychological distress and frequent visits,suggesting that integrating psychological screening into routine care may help identify at-risk patients.Prospective studies are needed to determine whether psychosomatic interventions can effectively reduce healthcare utilization in this population. 展开更多
关键词 Non-erosive reflux disease Epigastric pain syndrome Biopsychosocial model Outpatient visits frequency Crosssectional study
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Changes in knowledge and attitude after communitybased first-aid training:a prospective study with a 12-month follow-up 认领 引用
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作者 Shijiao Yan Wenning Fu +5 位作者 Ping Tan Chang Su Xuan Deng Jinlong Wang Chuanzhu Lyu Yanhong Yang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2026年第3期215-222,共8页
BACKGROUND:This study aims to evaluate the immediate and 12-month effects of communitybased first-aid training on public knowledge and attitude,assess satisfaction,and identify factors associated with score changes.ME... BACKGROUND:This study aims to evaluate the immediate and 12-month effects of communitybased first-aid training on public knowledge and attitude,assess satisfaction,and identify factors associated with score changes.METHODS:This was a prospective study.In 2022-2023,a total of 2,010 community residents in Hainan Province received first-aid training and completed structured questionnaires at baseline,immediately after training,and at 3,6,and 12 months after training.First-aid knowledge was assessed through 33 items,with a maximum total score of 33.First-aid attitude was evaluated using seven items,totaling a maximum score of 21.Satisfaction was measured on a 5-point Likert scale.Paired-sample t-tests were used to compare baseline and post-training scores,repeated-measures analysis of variance(ANOVA)was used to examine time effects,and multiple linear regression was used to analyze factors associated with score changes.RESULTS:The satisfaction score with the training was high(mean score>4.3 for all items).The first-aid knowledge and attitude scores increased significantly after training(first-aid knowledge at baseline,14.90±7.63;immediately after training,20.70±5.72,P<0.001;and attitude at baseline,17.52±2.29;immediately after training,17.89±1.54,P<0.001).At 12 months after training,knowledge scores declined slightly compared with those immediately after training but remained above baseline(time effect P<0.001),whereas attitude scores remained stable(time effect P<0.001).Knowledge improvement was greater among middle-income participants and less among participants with lower levels of education,those in professional occupations,widowed individuals,or those who had previously received first-aid training.Attitude improvements were more pronounced among male participants,younger participants,and those in the agriculture or sales/service sectors.CONCLUSION:Community-based first-aid training improved public first-aid knowledge and attitude and was well received by participants.While knowledge levels declined somewhat over time,attitude remained relatively stable,highlighting the importance of continuous reinforcement training.Personalized reinforcement strategies may be particularly beneficial for individuals with lower levels of education,specific professional backgrounds,widowhood,or prior training experience to further enhance training effectiveness. 展开更多
关键词 First aid Knowledge Attitude Practice Training Longitudinal studies
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Solid fuel use and heart disease in middle-aged and older Chinese populations:a prospective cohort study 认领 引用
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作者 Jun-Wen WANG Ke-Xin CHEN +8 位作者 Teng HU Yu-Yang YE Yi-Fei ZHAO Xin-Ru HU Jiang YU Simayi Abulikemu Mai-Lin WEI Jun MA Yong PENG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第2期100-112,共13页
BACKGROUND Solid fuel use for cooking and heating is a major environmental risk factor,yet its association with new-onset heart disease(HD)remains unclear.The aim of this study was to investigate the relationship betw... BACKGROUND Solid fuel use for cooking and heating is a major environmental risk factor,yet its association with new-onset heart disease(HD)remains unclear.The aim of this study was to investigate the relationship between solid fuel exposure and new-onset HD in a large cohort.METHODS Multivariable logistic regression models assessed associations between cooking/heating fuel types(coal,crop residue/wood,liquefied petroleum gas,natural gas,and others)and new-onset HD.Subgroup analyses explored effect modification by age,sex,education,smoking,alcohol use,and region.RESULTS A prospective cohort study included 5915 participants,with 781 participants(13.2%)developing new-onset HD.Coal use for cooking showed an initial association with new-onset HD risk(OR=1.41,95%CI:1.06–1.86,P=0.02),which attenuated after full adjustment(OR=1.28,95%CI:0.96–1.72,P=0.10).Coal use for heating demonstrated robust associations across all models(OR=1.86,95%CI:1.42–2.43,P<0.001).Crop residue/wood burning for heating was also significant(Model 2:OR=1.40,95%CI:1.06–1.86,P=0.02).Subgroup analyses revealed stronger associations among females,non-smokers,non-drinkers,and less-educated participants.Geographic stratification showed significant associations in southern but not northern regions.CONCLUSIONS Solid fuel use,particularly coal for heating,is associated with increased new-onset HD risk.Reducing solid fuel exposure is crucial for HD prevention in low-resource settings. 展开更多
关键词 petroleum gasnatural gasand solid fuel multivariable logistic regression models older populations middle aged heart disease prospective cohort study effect modificatio
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Sex-specific associations between exposure to metal mixtures and mitochondrial DNA copy number:A repeated-measures study 认领 引用
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作者 Junxiu He Xiaoting Ge +7 位作者 Sencai Lin Yu Bao Hong Cheng Sihan Hu Xiuming Feng Qinghua Fan Ying Yang Xiaobo Yang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第3期761-771,共11页
Few repeated-measures studies with multiple time points have evaluated the sex-specific association between mitochondrial DNA copy number(mtDNAcn)and long-term exposure to metal mixtures.We conducted a repeatedmeasure... Few repeated-measures studies with multiple time points have evaluated the sex-specific association between mitochondrial DNA copy number(mtDNAcn)and long-term exposure to metal mixtures.We conducted a repeatedmeasures study with three time points and 2550 observations in the manganese-exposed workers healthy cohort.Specifically,the blood concentrations of 15 metals and mtDNAcn were measured in 2012,2017,and 2021.We employed a machine learning approach(GLMMLASSO)to select the metals most associated with mtDNAcn and used Bayesian kernel machine regression to examine their joint effects.In cross-sectional analyses(2550 visits),statistical methods consistently showed Calcium(Ca)was positively associated with mtDNAcn among overall visits(β=0.292 in the linear mixed-effects model(LMM))and dominated the positive overall effects of magnesium,Ca,titanium,iron,nickel,rubidium on mtDNAcn.An inverted“U”-shaped exposure–response curve between Ca and mtDNAcn appeared in males but not in females.Interaction analysis showed the association between Ca and mtDNAcn was significantly modified by gender.In repeated-measures analyses(807 visits),we explored the tendency for metals and mtDNAcn to change over three time points;the results confirmed the cross-sectional analyses.In overall visits,the positive association between Ca and mtDNAcn remained significant(β=0.207 in LMM).For metal selection,Ca was identified as the predictor for mtDNAcn,and an inverted“U”-shaped exposure–response curve was found with mtDNAcn in males.Our findings reveal a consistent positive association between Ca and mtDNAcn with sex-dependent heterogeneity and suggest Ca may mitigate mitochondrial dysfunction induced by other metals. 展开更多
关键词 Mitochondrial DNA copy number(mtDNAcn) Metal mixtures Calcium(Ca) Sex-specific Repeated-measures study
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Clinical efficacy of optimized drug treatment for acute type A aortic dissection:insights from a multicenter retrospective cohort study 认领 引用
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作者 Shi-Pan Wang Hai-Yang Li +6 位作者 Yin-Fan Zhu Hao-Tian Wu Dong-Jie Li Yuan-Fei Zhao Lu Dai Wen-Jian Jiang Hong-Jia Zhang 《Military Medical Research》 SCIE CAS CSCD 2026年第3期507-510,共4页
Dear Editor,Acute aortic dissection(AAD)refers to the tearing of the aortic intima,with high-pressure blood flowing into the media.It can be classified into Stanford type A and type B according to whether the ascendin... Dear Editor,Acute aortic dissection(AAD)refers to the tearing of the aortic intima,with high-pressure blood flowing into the media.It can be classified into Stanford type A and type B according to whether the ascending aorta is involved.Acute type A aortic dissection(ATAAD)is a life-threatening cardiovascular disease with high mortality rates(approximately 50%and 1%–2% per hour)within the first 48 h[1]. 展开更多
关键词 Multicenter study Optimized drug treatment(ODP) Acute type A aortic dissection(ATAAD) Clinical prognosis
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Genetic dissection of salt tolerance architecture in Brassica napus at the seedling stage by genome-wide association study 认领 引用
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作者 Tinghai Yang Wei Zhang +7 位作者 Yue Shen Feng Chen Chunyun Wang Xiaoying Zhou Chengming Sun Sanxiong Fu Jiefu Zhang Xiaodong Wang 《Oil Crop Science》 CAS CSCD 2026年第2期138-149,共12页
Owing to the continuous increase in industrialization,the extent of soil salinization is escalating globally.Brassica napus is among the most advantageous field crops for the development and utilization of saline-alka... Owing to the continuous increase in industrialization,the extent of soil salinization is escalating globally.Brassica napus is among the most advantageous field crops for the development and utilization of saline-alkali land.Nevertheless,the molecular regulation of salt tolerance during the seedling stage in this species remains unclear.To explore this mechanism,an association population consisting of 202 accessions was subjected to a 257 mmol/L NaCl solution at the seedling(four-leaf)stage.After 14 days of salt treatment,the above-ground and under-ground fresh and dry weights of each accession line were measured,and the correlations between these traits were evaluated.By integrating phenotypic data with resequencing data,a genome-wide association study identified 2043 single nucleotide polymorphisms(SNPs)that were significantly associated with these traits.Ninety SNPs were detected repeatedly,with a single SNP accounting for 1.3%–5.29%of the phenotypic variation.Subsequently,two candidate genes were identified,and six germplasm resources with strong salt tolerance at the seedling stage were selected.These results will guide strategies for breeding salt-tolerant B.napus and will offer a theoretical foundation for the restoration and management of salinized land. 展开更多
关键词 Brassica napus Salt tolerance Genome-wide association study Seedling stage Single nucleotide polymorphism Candidate gene Germplasm resource
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