The use of bacteria to specifically migrate to cancerous tissue and elicit an antitumor immune response provides a promising platform against cancer with significantly high potency.With dozens of clinical trials under...The use of bacteria to specifically migrate to cancerous tissue and elicit an antitumor immune response provides a promising platform against cancer with significantly high potency.With dozens of clinical trials underway,some researchers hold the following views:“humans are nearing the first commercial live bacteria therapeutic.”However,the facultative anaerobe Salmonella typhimurium VNP20009,which is particularly safe and shows anticancer effects in preclinical studies,had failed in a phase I clinical trial due to low tumor regression and undesired dose-dependent side effects.This is almost certain to disappoint people’s inflated expectations,but it is noted that recent stateof-the-art research has turned attention to bacteria-mediated synergistic cancer therapy(BMSCT).In this review,the foundation of bacteria-mediated bio-therapy is outlined.Then,we summarize the potential benefits and challenges of bacterial bio-therapy in combination with different traditional anticancer therapeutic modalities(chemotherapy,photothermal therapy,reactive oxygen and nitrogen species therapy,immunotherapy,or prodrug-activating therapy)in the past 5 years.Next,we discuss multiple administration routes of BMSCT,highlighting potentiated antitumor responses and avoidance of potential side effects.Finally,we envision the opportunities and challenges for BMSCT development,with the purpose of inspiring medicinal scientists to widely utilize the microbiome approach in patient populations.展开更多
Understanding the specific contributions of ecosystem services(ES)to the Sustainable Development Goals(SDGs)is crucial,yet challenging,given their complex interrelationships.This study develops an integrated approach,...Understanding the specific contributions of ecosystem services(ES)to the Sustainable Development Goals(SDGs)is crucial,yet challenging,given their complex interrelationships.This study develops an integrated approach,combining network analysis and structural equation modeling,to elucidate how ESs related to food,water,and carbon interact with and influence the achievement of SDGs 2,6,7,11,12,13,and 15 in the Pearl River Basin(PRB)from 2000 to 2019.We independently evaluated the supply,demand,and flow of ESs,along with SDG scores.Our results show that despite an overall increase in the average SDG score in the PRB from 44.07 to 55.84over the two decades,spatial mismatches between ES supply and demand across cities intensified,primarily driven by ES flows.Notably,ES demand emerged as a dominant factor shaping SDG scores,particularly for SDG2(Zero Hunger),SDG 6(Clean Water and Sanitation),and SDG 15(Life on Land).Food-related ES flows exhibited the most significant positive impact on regional SDG performance.Furthermore,synergistic effects between ES supply(food,water,carbon)and SDGs strengthened over time,especially for SDG 12(Responsible Consumption and Production).Among the three ESs,the food ES has the highest impact on the SDGs,with coefficients of 0.28,0.47,and 0.24 for the ES supply,demand,and flow,respectively.This study introduces a novel framework for the basin scale that simultaneously quantifies both the ES supply-demand flows and their causal pathways to SDGs.These findings indicate that optimizing ES flows through improved resource allocation and cross-sectoral governance is a key mechanism for enhancing regional sustainability.展开更多
Nonlinear distortions from atmospheric turbulence and scattering critically degrade free-space optical(FSO)communication performance.We propose a hybrid Vol_LSTM framework combining the Volterra model's nonlinear ...Nonlinear distortions from atmospheric turbulence and scattering critically degrade free-space optical(FSO)communication performance.We propose a hybrid Vol_LSTM framework combining the Volterra model's nonlinear characterization with long short-term memory(LSTM)temporal dynamic modeling.This synergistic approach adaptively compensates atmospheric-induced distortions through parallel processing of instantaneous nonlinear effects and time-varying channel dynamics.Simulations and experiments demonstrate a 32 d B power budget with 31.53%performance improvement and 21%computational complexity reduction compared to conventional methods,alongside enhanced disturbance resilience.The framework's dual mechanism of model-based Volterra filtering and data-driven LSTM adaptation provides a practical solution for atmospheric-challenged FSO systems,advancing robust optical communication design.展开更多
在水利工程管理当中,从前期决策、勘察设计、建造到运营维护的全过程,引入全过程协同管理,可以产生和助力发挥协同效应.以都江堰工程为例,运用物理-事理-人理方法论(Wuli-Shili-Renli System Approach,以下简称WSR方法论),从物理、事理...在水利工程管理当中,从前期决策、勘察设计、建造到运营维护的全过程,引入全过程协同管理,可以产生和助力发挥协同效应.以都江堰工程为例,运用物理-事理-人理方法论(Wuli-Shili-Renli System Approach,以下简称WSR方法论),从物理、事理、人理角度,对协同管理进行系统分析,通过构建基于WSR系统的协同管理三维分析模型、协同管理分析矩阵和协同管理分析框架,为水利工程的协同管理提供启示和借鉴,助力于发挥水利工程协同管理全过程的协同效应.展开更多
基金Supported by National Natural Science Foundation of China,No.81773656Liaoning Revitalization Talents Program,No.XLYC1808017Shenyang Youth Science and Technology Innovation Talents Program,No.RC190454.
摘要The use of bacteria to specifically migrate to cancerous tissue and elicit an antitumor immune response provides a promising platform against cancer with significantly high potency.With dozens of clinical trials underway,some researchers hold the following views:“humans are nearing the first commercial live bacteria therapeutic.”However,the facultative anaerobe Salmonella typhimurium VNP20009,which is particularly safe and shows anticancer effects in preclinical studies,had failed in a phase I clinical trial due to low tumor regression and undesired dose-dependent side effects.This is almost certain to disappoint people’s inflated expectations,but it is noted that recent stateof-the-art research has turned attention to bacteria-mediated synergistic cancer therapy(BMSCT).In this review,the foundation of bacteria-mediated bio-therapy is outlined.Then,we summarize the potential benefits and challenges of bacterial bio-therapy in combination with different traditional anticancer therapeutic modalities(chemotherapy,photothermal therapy,reactive oxygen and nitrogen species therapy,immunotherapy,or prodrug-activating therapy)in the past 5 years.Next,we discuss multiple administration routes of BMSCT,highlighting potentiated antitumor responses and avoidance of potential side effects.Finally,we envision the opportunities and challenges for BMSCT development,with the purpose of inspiring medicinal scientists to widely utilize the microbiome approach in patient populations.
基金funded by National Natural Science of Foundation(Grant No.42371109)。
摘要Understanding the specific contributions of ecosystem services(ES)to the Sustainable Development Goals(SDGs)is crucial,yet challenging,given their complex interrelationships.This study develops an integrated approach,combining network analysis and structural equation modeling,to elucidate how ESs related to food,water,and carbon interact with and influence the achievement of SDGs 2,6,7,11,12,13,and 15 in the Pearl River Basin(PRB)from 2000 to 2019.We independently evaluated the supply,demand,and flow of ESs,along with SDG scores.Our results show that despite an overall increase in the average SDG score in the PRB from 44.07 to 55.84over the two decades,spatial mismatches between ES supply and demand across cities intensified,primarily driven by ES flows.Notably,ES demand emerged as a dominant factor shaping SDG scores,particularly for SDG2(Zero Hunger),SDG 6(Clean Water and Sanitation),and SDG 15(Life on Land).Food-related ES flows exhibited the most significant positive impact on regional SDG performance.Furthermore,synergistic effects between ES supply(food,water,carbon)and SDGs strengthened over time,especially for SDG 12(Responsible Consumption and Production).Among the three ESs,the food ES has the highest impact on the SDGs,with coefficients of 0.28,0.47,and 0.24 for the ES supply,demand,and flow,respectively.This study introduces a novel framework for the basin scale that simultaneously quantifies both the ES supply-demand flows and their causal pathways to SDGs.These findings indicate that optimizing ES flows through improved resource allocation and cross-sectoral governance is a key mechanism for enhancing regional sustainability.
基金supported by the Shenzhen Fundamental Research Program(Nos.JCY20231121110828001 and JCY20231121113641002)the Taipei University of Technology–Shenzhen University Joint Research Program(No.2024001)。
摘要Nonlinear distortions from atmospheric turbulence and scattering critically degrade free-space optical(FSO)communication performance.We propose a hybrid Vol_LSTM framework combining the Volterra model's nonlinear characterization with long short-term memory(LSTM)temporal dynamic modeling.This synergistic approach adaptively compensates atmospheric-induced distortions through parallel processing of instantaneous nonlinear effects and time-varying channel dynamics.Simulations and experiments demonstrate a 32 d B power budget with 31.53%performance improvement and 21%computational complexity reduction compared to conventional methods,alongside enhanced disturbance resilience.The framework's dual mechanism of model-based Volterra filtering and data-driven LSTM adaptation provides a practical solution for atmospheric-challenged FSO systems,advancing robust optical communication design.
摘要在水利工程管理当中,从前期决策、勘察设计、建造到运营维护的全过程,引入全过程协同管理,可以产生和助力发挥协同效应.以都江堰工程为例,运用物理-事理-人理方法论(Wuli-Shili-Renli System Approach,以下简称WSR方法论),从物理、事理、人理角度,对协同管理进行系统分析,通过构建基于WSR系统的协同管理三维分析模型、协同管理分析矩阵和协同管理分析框架,为水利工程的协同管理提供启示和借鉴,助力于发挥水利工程协同管理全过程的协同效应.