Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance ...Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.展开更多
Objective:This study aimed to develop a rapid,accurate pathogen detection system for emergency acute respiratory distress syndrome(ARDS),so as to improve the etiological diagnosis efficiency for ARDS patients.Methods:...Objective:This study aimed to develop a rapid,accurate pathogen detection system for emergency acute respiratory distress syndrome(ARDS),so as to improve the etiological diagnosis efficiency for ARDS patients.Methods:An integrated detection platform integrating nucleic acid extraction,multiplex amplification and fluorescence readout was constructed by combining microfluidic chip technology with multiplex loop-mediated isothermal amplification(mLAMP).The polydimethylsiloxane(PDMS)-based microfluidic chip was structurally optimized with eight independent amplification chambers preloaded with pathogen-specific LAMP primers and fluorescent probes targeting common ARDS-related pathogens,including influenza virus and Streptococcus pneumoniae,Aspergillus spp.Clinical samples were used for system performance validation,and the sensitivity,specificity and detection efficiency of the platform were evaluated with conventional real-time polymerase chain reaction(RT-PCR)as the gold standard.Results:The entire detection procedure from sample loading to result interpretation was completed within 90 min using the proposed system.The platform achieved a limit of detection of 10 copies/μL for target pathogens with a specificity of 95.7%and no observable cross-reactivity.The clinical detection consistency with standard PCR reached 96.2%.The miniaturized chip with a dimension of 8×5×1 cm is portable and fully adaptable to point-of-care testing scenarios.Conclusion:This study establishes a portable,high-efficiency mLAMP microfluidic detection system.It enables rapid and accurate etiological detection for emergency ARDS,providing a reliable technical basis for early anti-infective precise intervention and clinical prognosis improvement.展开更多
Vanadium flow batteries(VFBs)are well suitable for grid-scale energy storage owing to their long lifespan,high efficiency and safety.State of charge(SOC)monitoring is essential for battery health assessment and system...Vanadium flow batteries(VFBs)are well suitable for grid-scale energy storage owing to their long lifespan,high efficiency and safety.State of charge(SOC)monitoring is essential for battery health assessment and system management.However,accurate SOC determination during operation remains challenging due to vanadium ion crossover and side reactions that disrupt the valence and concentration balance between positive and negative electrolytes.Herein,an inverted transformer model,namely iTransformer,is employed to predict the SOC in VFB systems during charge–discharge cycles.The iTransformer-SOC model can achieve high accuracy and robustness.Even with training limited to the first three cycles,the model predicts SOC for the next 21 cycles with mean absolute percentage error(MAPE)less than 0.03.It can adapt to power variations and electrolyte rebalancing scenarios.Most importantly,an iTransformer-based SOC monitoring system was validated and confirmed by a 10 kW VFB system,demonstrating superior performance in predicting SOC of complete charge–discharge cycles(MAPE<0.05,less than 1/3 of the traditional open-circuit voltage(OCV)method's error).This datadriven approach provides a robust framework for real-time SOC monitoring in VFB systems,serving as a complementary alternative to physics-based model without requiring prior knowledge of system dynamics.展开更多
Wafer-scale fabrication of high-performance microelectro-mechanical systems(MEMS)bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into su...Wafer-scale fabrication of high-performance microelectro-mechanical systems(MEMS)bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into suspended MEMS architectures.Here,a wafer-level manufacturing strategy is presented that redefines the MEMS process flow as“film first,cantilever later.”Through kinetically controlled self-assembly,wet-chemically synthesized Pd/SnO2nanospheres are transferred as dense,uniform monolithic films onto 8-inch wafers.An HfO2interface passivation patterning technology resolves long-standing incompatibility between functional sensing films and silicon substrates,enabling precise patterning and reliable integration on suspended MEMS cantilevers.The resulting Pd/SnO2MEMS H2 chips are fabricated onto an 8-inch wafer,demonstrating high sensitivity and consistency.This approach overcomes long-standing wafer-level manufacturing challenges in the formation and patterning of high-performance nanomaterials film,establishing a fully integrated wafer-level process that fundamentally redefines the manufacturing route for tetramethylammonium hydroxide-resistant nanomaterial-based MEMS sensing chips.展开更多
The electro-optic modulator(EOM)converts electronic signals into the optical domain.EOM cascading is a key technology in modern wireless communication,microwave photonic systems,and photonic computing.However,the scal...The electro-optic modulator(EOM)converts electronic signals into the optical domain.EOM cascading is a key technology in modern wireless communication,microwave photonic systems,and photonic computing.However,the scalable cascade of EOMs is hindered by the accumulation of modulator insertion losses,which critically degrade system performance.Erbium-doped waveguide amplifiers(EDWAs)have emerged as a pivotal technology recently,enabling efficient optical loss compensation and facilitating large-scale photonic integration.展开更多
Real-time identification of rock chip size and shape distributions from muck images plays a critical role in intelligently optimizing cutterhead thrust and torque parameters for tunnel boring machines(TBM).However,com...Real-time identification of rock chip size and shape distributions from muck images plays a critical role in intelligently optimizing cutterhead thrust and torque parameters for tunnel boring machines(TBM).However,complex light environments in field images are difficult to recognize via traditional methods.This paper proposes a U-Net-SAM framework integrating semantic segmentation and the vision foundation model—Segment Anything Model(SAM),combined with dropout-based uncertainty analysis,achieving efficient rock chip segmentation and parameter quantification.First,a U-Net is trained to identify the rock mass centroid as an automatic SAM prompt.Next,an overlap region optimization strategy based on Intersection over Union(IoU)and a noise filtering method is employed to tackle boundary blurring and particle adhesion.Finally,a Dropout layer is added to implement the committee-based uncertainty analysis model and quantify predictive uncertainty.Results show that:(1)U-Net-SAM improves mean F1-score and PA by 9.1%and 7.8%over U-Net;(2)A strong correlation between prediction standard deviation(SD)and error rate validates the proposed uncertainty quantification strategy.This framework provides reliable rock chip perception for intelligent TBM tunneling,with potential applications in other engineering scenarios.展开更多
Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which h...Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which have been associated with multiple health-promoting properties(Azuma et al.,2008;Gurbuz et al.,2018).Given its significant hybrid vigor,F1 hybrid varieties are widely preferred in commercial cultivation(Mistry et al.,2018).However,traditional breeding practices predominantly rely on phenotypic selection,a process that is not only labor-intensive but also time-consuming.展开更多
The inherent emission-detection spectral overlap in multi-quantum well(MQW)structures enables on-chip optical interconnects on aⅢ-nitride platform.In this work,by using the spectral overlap from 383 nm to 410 nm,MQW ...The inherent emission-detection spectral overlap in multi-quantum well(MQW)structures enables on-chip optical interconnects on aⅢ-nitride platform.In this work,by using the spectral overlap from 383 nm to 410 nm,MQW diodes act as multifunctional optoelectronic nodes that can be configured as either optical transmitters or receivers.We introduce a time-division multiplexing scheme to realize bidirectional data exchange through a single waveguide,while parallel waveguides further enable full-duplex optical interconnects.展开更多
Current treatments for neuropathic pain are suboptimal,necessitating the search for more effective therapeutics.Our previous study showed that inhibition of neuroinflammation in the spinal cord induced analgesic effec...Current treatments for neuropathic pain are suboptimal,necessitating the search for more effective therapeutics.Our previous study showed that inhibition of neuroinflammation in the spinal cord induced analgesic effects,and focal repetitive trans-spinal magnetic stimulation showed an anti-neuroinflammatory effect in spinal cord injury rat models.Here,we speculated that repetitive trans-spinal magnetic stimulation might induce an anti-inflammatory effect to alleviate neuropathic pain by upregulating calmodulin-dependent protein kinase kinase beta(CaMKKβ)/adenosine 5′-monophosphate-activated protein kinase(AMPK)/suppressor of cytokine signaling-3(SOCS3)signaling in microglia.Experiments have found that non-invasive focal repetitive trans-spinal magnetic stimulation effectively alleviates mechanical allodynia and spinal neuroinflammation in rats with neuropathic pain induced by chronic sciatic nerve ligation.Further research found that repetitive trans-spinal magnetic stimulation upregulated the expression of SOCS3 in spinal microglia,which subsequently inhibited the phosphorylation of p38 mitogen-activated protein kinase and signal transducer and activator of transcription 3 and nuclear factor-kappa B p65 nuclear translocation in rats with neuropathic pain,thereby suppressing neuroinflammation.The upregulation of SOCS3 by repetitive trans-spinal magnetic stimulation may be achieved through the activation of the CaMKKβ/AMPK signaling pathway in microglia.The results suggested that focal repetitive trans-spinal magnetic stimulation inhibits spinal neuroinflammation and alleviates neuropathic pain by activating the CaMKKβ/AMPK/SOCS3 signaling pathway in spinal microglia.This mechanism provides an effective noninvasive treatment for neuropathic pain caused by peripheral nerve injury.展开更多
Analyzing optical information is a multidimensional task that spans measuring temporal and spatial responses(e.g.,in telecommunications and imaging)to detecting changes in intensity,polarization,and other key properti...Analyzing optical information is a multidimensional task that spans measuring temporal and spatial responses(e.g.,in telecommunications and imaging)to detecting changes in intensity,polarization,and other key properties of light(e.g.,in microscopy and sensing).None of them,however,is as useful as analyzing the spectrum for understanding the source or any possible material the light originated from or passed through[1].展开更多
Neuroinflammation plays an important role in the occurrence and development of neurological diseases.In addition to microglia,the role of astrocytes in neuroinflammation has gradually attracted attention.Photobiomodul...Neuroinflammation plays an important role in the occurrence and development of neurological diseases.In addition to microglia,the role of astrocytes in neuroinflammation has gradually attracted attention.Photobiomodulation(PBM),as a non-invasive treatment,has been shown potential to alleviate inflammation of microglia or astrocytes.In this study,the spatiotemporal regulation and molecular mechanism of PBM on astrocytes were deeply explored by analyzing the effects and genomics at different time points.The results showed that PBM significantly attenuated the upregulation of inflammatory factors and mitochondrial dysfunction in astrocytes under LPS stimulation for 4 h and 24 h.RNA-seq analysis showed that the JAK-STAT pathway played an important role in the early stage of both LPS-induced astrocytic neuroin-flammation and PBM-alleviated astrocytic neuroinflammation.Under PBM treatment,Stat5a translocation to the nucleus and upregulated Socs3 expression were observed in LPS-treated astrocytes,which may inhibit the overactivation of the JAK-STAT inflammatory signaling pathway and thus alleviate astrocyte inflammation.Taken together,this study provides new insight into the molecular mechanism of the potential application of PBM in the treatment of neuroinflammation.展开更多
The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a mol...The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a molding process,which enables the batch detection of pathogens.It explores the rapid lysis and elution processes of pathogens within the microfluidic chips to ensure that nucleic acid extraction,elution,and amplification are completed entirely within the chip.This chip can extract nucleic acids from samples in just 10 min,achieving an extraction efficiency comparable to that of traditional in-tube methods.An oil phase is pre-loaded into the chip to effectively prevent aerosol contamination.This approach allows for the simultaneous detection of 21 common respiratory pathogens,with a detection limit of 10 copies per reaction.Furthermore,applications involving clinical samples demonstrate significant practicality.Compared to many traditional in-tube pathogen detection methods and molecular biology technologies that utilize microfluidic chips,this detection chip not only enables simultaneous detection of multiple pathogens but also demonstrates high sensitivity.展开更多
Clonal hematopoiesis of indeterminate potential(CHIP),driven by leukemia-related somatic mutations in hematopoietic stem cells,previously recognized as a major risk factor for hematological malignancies,has now emerge...Clonal hematopoiesis of indeterminate potential(CHIP),driven by leukemia-related somatic mutations in hematopoietic stem cells,previously recognized as a major risk factor for hematological malignancies,has now emerged as a potent risk factor for chronic inflammation and diverse non-hematologic diseases.CHIP-associated DNA methyltransferase 3 alpha(DNMT3A),tet methylcytosine dioxygenase 2(TET2),and additional sex combs like 1(ASXL1)mutations alter epigenetic programs,skew myelopoiesis,and increase proinflammatory cytokines,resulting in chronic inflammation and immune imbalance.This review integrates mechanistic insights with clinical evidence to delineate CHIP's roles in solid tumors,cardiovascular disorders,and metabolic dysregulation,with an extended discussion of renal dysfunction and neurodegenerative conditions.Furthermore,we also discuss CHIP's diagnostic and therapeutic impacts across multiple disease contexts,advocating for mutation-specific diagnostic paradigms to guide therapeutic interventions.展开更多
Circulating tumor cells(CTCs)are cells that become detached from a primary tumor and enter the vascular or lymphatic system.These cells contain nearly the entire genetic information of the primary tumor.Enrichment and...Circulating tumor cells(CTCs)are cells that become detached from a primary tumor and enter the vascular or lymphatic system.These cells contain nearly the entire genetic information of the primary tumor.Enrichment and detection of CTCs play a crucial role in prognostications and risk assessments of tumor metastasis and recurrence,evaluation of efficacy and potential medications for precision tumor therapy,and detection of dynamic biomarkers during tumor treatment.Current methods of CTC capture often face the challenge of balancing capture rate and purity.To address these issues,we propose a microfluidic biochip based on the principle of immunoaffinity,which incorporates a herringbone microchannel and deterministic lateral displacement(DLD)technology for the capture of CTCs.By manipulating the internal structural design of the microfluidic chip,we optimized the flow field within the chip,thereby enhancing the contact frequency between cells and aptamers and ultimately improving the capture rate.The proposed chip demonstrated a capture efficiency of approximately 91.87%for human breast cancer cells(MCF7),with a release rate of 77.5%.The relative activity of the released cells was approximately 94.08%.Notably,the specificity of the aptamers toward tumor cell surface antigens enables high-purity capture.Additionally,the use of DNA enzymes to digest aptamers facilitates the release of high-activity CTCs,offering a method to simultaneously achieve a high capture rate,purity,and activity enrichment.展开更多
The long-term carbon(C)sequestration potential of plantations hinges on the dynamics and persistence of mature forest C sinks,yet how C storage and stability evolve with increasing forest age remains unclear.Here,we e...The long-term carbon(C)sequestration potential of plantations hinges on the dynamics and persistence of mature forest C sinks,yet how C storage and stability evolve with increasing forest age remains unclear.Here,we examined a chronosequence of mature Pinus massoniana reforestations(32-,45-,and 60-year-old)to quantify ecosystem C storage across plant(tree,shrub,and herb),litter,and soil(0-100 cm)pools,and to assess soil organic carbon(SOC)stability via the ratio of mineral-associated organic carbon(MAOC)vs.particulate organic carbon(POC).Results showed that the total ecosystem C storage remained relatively constant across stand developmental stages,reflecting that plant C storage increased 53.4%from 32 to 45 years,then declined,while SOC storage decreased 53.9%from 32 to 45 years,then increased.In contrast,the 64.0%rise in the MAOC/POC ratio from 32 to 60 years may reflect a trend of enhanced SOC stability.Microbial necromass constituted 45.9%-64.8%of SOC,with fungal necromass dominating bacterial necromass,especially in the subsoils(20-100 cm).Additionally,SOC,POC,and MAOC showed strong positive correlations with microbial necromass but exhibited weak associations with plant and litter C pools.The MAOC/POC ratio correlated strongly with the ratio of fungal necromass carbon(FNC)vs.bacterial necromass carbon(BNC).These results reveal that microbial-especially fungal-necromass may underpin the soil C stability and ecosystem C persistence of mature pine reforestations.Therefore,accurately predicting the long-term C sequestration of mature reforestation requires a mechanistic understanding that integrates both SOC stability and microbial necromass dynamics.展开更多
To achieve continuous demodulation,high precision,and high resolution in the C-band,this paper designs,simulates and prepares a 30-channel array waveguide grating(AWG)based on a silicon dioxide planar optical circuit ...To achieve continuous demodulation,high precision,and high resolution in the C-band,this paper designs,simulates and prepares a 30-channel array waveguide grating(AWG)based on a silicon dioxide planar optical circuit for fiber Bragg grating(FBG)interrogation and couples the prepared AWG with a photodetector array using hybrid integration technology.The test results indicate that the AWG has a good transmission spectrum,a 3 dB bandwidth of 2.15 nm,an insertion loss of approximately 3.6–4.2 dB,and crosstalk of less than−30 dB.The FBG interrogation system can achieve continuous demodulation in the dynamic range of 1521–1569 nm,and realize continuous demodulation in the C-band with a wavelength resolution of 1 pm and a demodulation accuracy of 5.8 pm.This demodulation method provides an optimization direction for researching FBG interrogation systems based on AWGs.展开更多
We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by&quo...We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China".We apologized for the inconvenience caused by this error.展开更多
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
In recent years,mature advanced packaging technologies have increasingly enabled the integration of multiple small dies into larger chips,while retaining chip-scale density and high-bandwidth interconnects.To address ...In recent years,mature advanced packaging technologies have increasingly enabled the integration of multiple small dies into larger chips,while retaining chip-scale density and high-bandwidth interconnects.To address the inefficiencies of manual design and the challenges of heterogeneous optimization in wafer-scale chip(WSC)development,we systematically explore key factors in WSC architecture design.We integrate chip layout,operator mapping,and hardware–software codesign,and formulate the WSC architecture exploration problem as a multi-objective optimization task.First,we establish a hierarchical architecture model for WSCs,unifying the quantification of core constraints and interconnect topology constraints;second,we propose a hierarchical multi-objective collaborative optimization framework to jointly optimize physical constraints and task mapping communication patterns;finally,we develop a WSC optimizer toolchain that supports mixed-granularity simulation and generates optimal configurations for representative workloads.Experimental results demonstrate that compared with traditional computer architectures,the optimized architectures generated by our WSC optimizer achieve up to a 22×throughput improvement and a 5×latency reduction in application domains,such as cryptographic decryption and signal processing.展开更多
基金the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Programthe Deanship of Scientific Research at Northern Border University,Arar,KSA for funding this research work through the project number“NBU-FFR-2025-2903-09”.
摘要Network-on-Chip(NoC)systems are progressively deployed in connecting massively parallel megacore systems in the new computing architecture.As a result,application mapping has become an important aspect of performance and scalability,as current trends require the distribution of computation across network nodes/points.In this paper,we survey a large number of mapping and scheduling techniques designed for NoC architectures.This time,we concentrated on 3D systems.We take a systematic literature review approach to analyze existing methods across static,dynamic,hybrid,and machine-learning-based approaches,alongside preliminary AI-based dynamic models in recent works.We classify them into several main aspects covering power-aware mapping,fault tolerance,load-balancing,and adaptive for dynamic workloads.Also,we assess the efficacy of each method against performance parameters,such as latency,throughput,response time,and error rate.Key challenges,including energy efficiency,real-time adaptability,and reinforcement learning integration,are highlighted as well.To the best of our knowledge,this is one of the recent reviews that identifies both traditional and AI-based algorithms for mapping over a modern NoC,and opens research challenges.Finally,we provide directions for future work toward improved adaptability and scalability via lightweight learned models and hierarchical mapping frameworks.
摘要Objective:This study aimed to develop a rapid,accurate pathogen detection system for emergency acute respiratory distress syndrome(ARDS),so as to improve the etiological diagnosis efficiency for ARDS patients.Methods:An integrated detection platform integrating nucleic acid extraction,multiplex amplification and fluorescence readout was constructed by combining microfluidic chip technology with multiplex loop-mediated isothermal amplification(mLAMP).The polydimethylsiloxane(PDMS)-based microfluidic chip was structurally optimized with eight independent amplification chambers preloaded with pathogen-specific LAMP primers and fluorescent probes targeting common ARDS-related pathogens,including influenza virus and Streptococcus pneumoniae,Aspergillus spp.Clinical samples were used for system performance validation,and the sensitivity,specificity and detection efficiency of the platform were evaluated with conventional real-time polymerase chain reaction(RT-PCR)as the gold standard.Results:The entire detection procedure from sample loading to result interpretation was completed within 90 min using the proposed system.The platform achieved a limit of detection of 10 copies/μL for target pathogens with a specificity of 95.7%and no observable cross-reactivity.The clinical detection consistency with standard PCR reached 96.2%.The miniaturized chip with a dimension of 8×5×1 cm is portable and fully adaptable to point-of-care testing scenarios.Conclusion:This study establishes a portable,high-efficiency mLAMP microfluidic detection system.It enables rapid and accurate etiological detection for emergency ARDS,providing a reliable technical basis for early anti-infective precise intervention and clinical prognosis improvement.
基金supported by the Key R&D Projects of the National Natural Science Foundation of China(2022YFB2404904)the National Natural Science Foundation of China(22309178)+1 种基金the Strategic Priority Research Program of the CAS(XDA0400402)the Liaoning International Cooperation Project(2023JH2/10700002)。
摘要Vanadium flow batteries(VFBs)are well suitable for grid-scale energy storage owing to their long lifespan,high efficiency and safety.State of charge(SOC)monitoring is essential for battery health assessment and system management.However,accurate SOC determination during operation remains challenging due to vanadium ion crossover and side reactions that disrupt the valence and concentration balance between positive and negative electrolytes.Herein,an inverted transformer model,namely iTransformer,is employed to predict the SOC in VFB systems during charge–discharge cycles.The iTransformer-SOC model can achieve high accuracy and robustness.Even with training limited to the first three cycles,the model predicts SOC for the next 21 cycles with mean absolute percentage error(MAPE)less than 0.03.It can adapt to power variations and electrolyte rebalancing scenarios.Most importantly,an iTransformer-based SOC monitoring system was validated and confirmed by a 10 kW VFB system,demonstrating superior performance in predicting SOC of complete charge–discharge cycles(MAPE<0.05,less than 1/3 of the traditional open-circuit voltage(OCV)method's error).This datadriven approach provides a robust framework for real-time SOC monitoring in VFB systems,serving as a complementary alternative to physics-based model without requiring prior knowledge of system dynamics.
基金supported by the National Key R&D Program of China(2020YFB2008701).
摘要Wafer-scale fabrication of high-performance microelectro-mechanical systems(MEMS)bio/chemical sensing chips remains constrained by the absence of reliable methods for integrating high-performance nanomaterials into suspended MEMS architectures.Here,a wafer-level manufacturing strategy is presented that redefines the MEMS process flow as“film first,cantilever later.”Through kinetically controlled self-assembly,wet-chemically synthesized Pd/SnO2nanospheres are transferred as dense,uniform monolithic films onto 8-inch wafers.An HfO2interface passivation patterning technology resolves long-standing incompatibility between functional sensing films and silicon substrates,enabling precise patterning and reliable integration on suspended MEMS cantilevers.The resulting Pd/SnO2MEMS H2 chips are fabricated onto an 8-inch wafer,demonstrating high sensitivity and consistency.This approach overcomes long-standing wafer-level manufacturing challenges in the formation and patterning of high-performance nanomaterials film,establishing a fully integrated wafer-level process that fundamentally redefines the manufacturing route for tetramethylammonium hydroxide-resistant nanomaterial-based MEMS sensing chips.
基金National Natural Science Foundation of China(T2225023,62405181)。
摘要The electro-optic modulator(EOM)converts electronic signals into the optical domain.EOM cascading is a key technology in modern wireless communication,microwave photonic systems,and photonic computing.However,the scalable cascade of EOMs is hindered by the accumulation of modulator insertion losses,which critically degrade system performance.Erbium-doped waveguide amplifiers(EDWAs)have emerged as a pivotal technology recently,enabling efficient optical loss compensation and facilitating large-scale photonic integration.
基金financial support of National Natural Science Foundation of China(Grant No.52008039)the Natural Science Foundation of Hunan Province(Grant No.2021JJ40592)support from the Research Grants Council of Hong Kong(Grant No.GRF#16208224).
摘要Real-time identification of rock chip size and shape distributions from muck images plays a critical role in intelligently optimizing cutterhead thrust and torque parameters for tunnel boring machines(TBM).However,complex light environments in field images are difficult to recognize via traditional methods.This paper proposes a U-Net-SAM framework integrating semantic segmentation and the vision foundation model—Segment Anything Model(SAM),combined with dropout-based uncertainty analysis,achieving efficient rock chip segmentation and parameter quantification.First,a U-Net is trained to identify the rock mass centroid as an automatic SAM prompt.Next,an overlap region optimization strategy based on Intersection over Union(IoU)and a noise filtering method is employed to tackle boundary blurring and particle adhesion.Finally,a Dropout layer is added to implement the committee-based uncertainty analysis model and quantify predictive uncertainty.Results show that:(1)U-Net-SAM improves mean F1-score and PA by 9.1%and 7.8%over U-Net;(2)A strong correlation between prediction standard deviation(SD)and error rate validates the proposed uncertainty quantification strategy.This framework provides reliable rock chip perception for intelligent TBM tunneling,with potential applications in other engineering scenarios.
基金supported by Yuelushan Laboratory Breeding Program(Grant No.YLS-2025-ZY02013)The Project of National Key Laboratory for Tropical Crop Breeding(Grant No.NKLTCB202341)+4 种基金The New Variety Breeding Project of the Major Science and Technology Projects of Zhejiang(Grant No.2021C02065-1-3)Hunan Provincial Agricultural Science and Technology Innovation Fund Project(Grant No.2025CX115)Key R&D Projects in Hainan Province(Grant No.ZDYF2023XDNY041)Central Public-interest Scientific Institution Basal Research Fund(Grant No.1630062022003)2024 Sanya Technology Stars Program(Grant No.2024KJFX022).
摘要Eggplant(Solanum melongena L.)is a globally important vegetable crop,renowned for its nutritional value and economic significance.It is abundant in bioactive compounds such as anthocyanins and chlorogenic acid,which have been associated with multiple health-promoting properties(Azuma et al.,2008;Gurbuz et al.,2018).Given its significant hybrid vigor,F1 hybrid varieties are widely preferred in commercial cultivation(Mistry et al.,2018).However,traditional breeding practices predominantly rely on phenotypic selection,a process that is not only labor-intensive but also time-consuming.
基金National Natural Science Foundation of China(U21A20495)Natural Science Foundation of Jiangsu Province(BG2024023)Higher Education Discipline Innovation Project(D17018)。
摘要The inherent emission-detection spectral overlap in multi-quantum well(MQW)structures enables on-chip optical interconnects on aⅢ-nitride platform.In this work,by using the spectral overlap from 383 nm to 410 nm,MQW diodes act as multifunctional optoelectronic nodes that can be configured as either optical transmitters or receivers.We introduce a time-division multiplexing scheme to realize bidirectional data exchange through a single waveguide,while parallel waveguides further enable full-duplex optical interconnects.
基金National Natural Science Foundation of China,Nos.82302877(to QW),82172541(to TW)the Natural Science Foundation of Hunan Province,No.2023JJ30549(to QW)Clinical Medical Technology Innovation Guidance Project of Hunan Provincial Science and Technology Department,No.2021SK51815(to QW).
摘要Current treatments for neuropathic pain are suboptimal,necessitating the search for more effective therapeutics.Our previous study showed that inhibition of neuroinflammation in the spinal cord induced analgesic effects,and focal repetitive trans-spinal magnetic stimulation showed an anti-neuroinflammatory effect in spinal cord injury rat models.Here,we speculated that repetitive trans-spinal magnetic stimulation might induce an anti-inflammatory effect to alleviate neuropathic pain by upregulating calmodulin-dependent protein kinase kinase beta(CaMKKβ)/adenosine 5′-monophosphate-activated protein kinase(AMPK)/suppressor of cytokine signaling-3(SOCS3)signaling in microglia.Experiments have found that non-invasive focal repetitive trans-spinal magnetic stimulation effectively alleviates mechanical allodynia and spinal neuroinflammation in rats with neuropathic pain induced by chronic sciatic nerve ligation.Further research found that repetitive trans-spinal magnetic stimulation upregulated the expression of SOCS3 in spinal microglia,which subsequently inhibited the phosphorylation of p38 mitogen-activated protein kinase and signal transducer and activator of transcription 3 and nuclear factor-kappa B p65 nuclear translocation in rats with neuropathic pain,thereby suppressing neuroinflammation.The upregulation of SOCS3 by repetitive trans-spinal magnetic stimulation may be achieved through the activation of the CaMKKβ/AMPK signaling pathway in microglia.The results suggested that focal repetitive trans-spinal magnetic stimulation inhibits spinal neuroinflammation and alleviates neuropathic pain by activating the CaMKKβ/AMPK/SOCS3 signaling pathway in spinal microglia.This mechanism provides an effective noninvasive treatment for neuropathic pain caused by peripheral nerve injury.
摘要Analyzing optical information is a multidimensional task that spans measuring temporal and spatial responses(e.g.,in telecommunications and imaging)to detecting changes in intensity,polarization,and other key properties of light(e.g.,in microscopy and sensing).None of them,however,is as useful as analyzing the spectrum for understanding the source or any possible material the light originated from or passed through[1].
基金funded in part by the STI2030-Major Projects(2022ZD0212200)Hainan Province Key Area R&D Program(KJRC2023C30)+1 种基金Project of Collaborative Innovation Center of One Health(XTCX2022JKB02)Sanya Yazhou Bay Science and Technology City(SKJC-JYRC-2024-38).
摘要Neuroinflammation plays an important role in the occurrence and development of neurological diseases.In addition to microglia,the role of astrocytes in neuroinflammation has gradually attracted attention.Photobiomodulation(PBM),as a non-invasive treatment,has been shown potential to alleviate inflammation of microglia or astrocytes.In this study,the spatiotemporal regulation and molecular mechanism of PBM on astrocytes were deeply explored by analyzing the effects and genomics at different time points.The results showed that PBM significantly attenuated the upregulation of inflammatory factors and mitochondrial dysfunction in astrocytes under LPS stimulation for 4 h and 24 h.RNA-seq analysis showed that the JAK-STAT pathway played an important role in the early stage of both LPS-induced astrocytic neuroin-flammation and PBM-alleviated astrocytic neuroinflammation.Under PBM treatment,Stat5a translocation to the nucleus and upregulated Socs3 expression were observed in LPS-treated astrocytes,which may inhibit the overactivation of the JAK-STAT inflammatory signaling pathway and thus alleviate astrocyte inflammation.Taken together,this study provides new insight into the molecular mechanism of the potential application of PBM in the treatment of neuroinflammation.
基金supported by grants from the National Key Research and Development Program of China(Nos.2023YFA0915200,2023YFA0915204)the Equipment Research and Development Projects of the Chinese Academy of Sciences(No.PTYQ2024YZ0010)+3 种基金the Science and Technology Commission of Shanghai Municipality Project(No.XTCX-KJ-2024-038)the Natural Science Foundation of Hebei Province of China(No.H2024206249)the Postdoctoral Fellowship Program of CPSF(No.GZC20232838)Science and Technology Commission of Shanghai Municipality(No.22S31901700).
摘要The implementation of multiple pathogen testing is essential for a rapid response to future outbreaks and for reducing disease transmission.This study introduces a 96-channel microfluidic chip,fabricated through a molding process,which enables the batch detection of pathogens.It explores the rapid lysis and elution processes of pathogens within the microfluidic chips to ensure that nucleic acid extraction,elution,and amplification are completed entirely within the chip.This chip can extract nucleic acids from samples in just 10 min,achieving an extraction efficiency comparable to that of traditional in-tube methods.An oil phase is pre-loaded into the chip to effectively prevent aerosol contamination.This approach allows for the simultaneous detection of 21 common respiratory pathogens,with a detection limit of 10 copies per reaction.Furthermore,applications involving clinical samples demonstrate significant practicality.Compared to many traditional in-tube pathogen detection methods and molecular biology technologies that utilize microfluidic chips,this detection chip not only enables simultaneous detection of multiple pathogens but also demonstrates high sensitivity.
基金supported by the National Natural Science Foundation of China(82270147)。
摘要Clonal hematopoiesis of indeterminate potential(CHIP),driven by leukemia-related somatic mutations in hematopoietic stem cells,previously recognized as a major risk factor for hematological malignancies,has now emerged as a potent risk factor for chronic inflammation and diverse non-hematologic diseases.CHIP-associated DNA methyltransferase 3 alpha(DNMT3A),tet methylcytosine dioxygenase 2(TET2),and additional sex combs like 1(ASXL1)mutations alter epigenetic programs,skew myelopoiesis,and increase proinflammatory cytokines,resulting in chronic inflammation and immune imbalance.This review integrates mechanistic insights with clinical evidence to delineate CHIP's roles in solid tumors,cardiovascular disorders,and metabolic dysregulation,with an extended discussion of renal dysfunction and neurodegenerative conditions.Furthermore,we also discuss CHIP's diagnostic and therapeutic impacts across multiple disease contexts,advocating for mutation-specific diagnostic paradigms to guide therapeutic interventions.
基金supported by the State Key Laboratory of High performance Precision Manufacturing(No.HPMKF202412)the Zhejiang Provincial Natural Science Foundation of China(No.LZ25E050001)+1 种基金the National Natural Science Foundation of China(No.52275294)the Zhejiang Provincial‘Pioneer Leading Swan+X’Science and Technology Program(No.2025C02122),China.
摘要Circulating tumor cells(CTCs)are cells that become detached from a primary tumor and enter the vascular or lymphatic system.These cells contain nearly the entire genetic information of the primary tumor.Enrichment and detection of CTCs play a crucial role in prognostications and risk assessments of tumor metastasis and recurrence,evaluation of efficacy and potential medications for precision tumor therapy,and detection of dynamic biomarkers during tumor treatment.Current methods of CTC capture often face the challenge of balancing capture rate and purity.To address these issues,we propose a microfluidic biochip based on the principle of immunoaffinity,which incorporates a herringbone microchannel and deterministic lateral displacement(DLD)technology for the capture of CTCs.By manipulating the internal structural design of the microfluidic chip,we optimized the flow field within the chip,thereby enhancing the contact frequency between cells and aptamers and ultimately improving the capture rate.The proposed chip demonstrated a capture efficiency of approximately 91.87%for human breast cancer cells(MCF7),with a release rate of 77.5%.The relative activity of the released cells was approximately 94.08%.Notably,the specificity of the aptamers toward tumor cell surface antigens enables high-purity capture.Additionally,the use of DNA enzymes to digest aptamers facilitates the release of high-activity CTCs,offering a method to simultaneously achieve a high capture rate,purity,and activity enrichment.
基金supported by the National Natural Science Foundation of China(Nos.32460379 and 32360259)Guizhou Provincial Basic Research Program(ZK[2025]ZHONGDIAN070,ZK[2022]YIBAN101,and ZK[2023]YIBAN110)+1 种基金d Natural Science Project of Guizhou University[202131]Josep Pe~nuelas and Jordi Sardans are financially supported by the Spanish Government grants PID2022-140808NB-I00 and PID2023-153125NB-I00 funded by the MICIU/AEI/10.13039/501100011033 and FEDER,EU.
摘要The long-term carbon(C)sequestration potential of plantations hinges on the dynamics and persistence of mature forest C sinks,yet how C storage and stability evolve with increasing forest age remains unclear.Here,we examined a chronosequence of mature Pinus massoniana reforestations(32-,45-,and 60-year-old)to quantify ecosystem C storage across plant(tree,shrub,and herb),litter,and soil(0-100 cm)pools,and to assess soil organic carbon(SOC)stability via the ratio of mineral-associated organic carbon(MAOC)vs.particulate organic carbon(POC).Results showed that the total ecosystem C storage remained relatively constant across stand developmental stages,reflecting that plant C storage increased 53.4%from 32 to 45 years,then declined,while SOC storage decreased 53.9%from 32 to 45 years,then increased.In contrast,the 64.0%rise in the MAOC/POC ratio from 32 to 60 years may reflect a trend of enhanced SOC stability.Microbial necromass constituted 45.9%-64.8%of SOC,with fungal necromass dominating bacterial necromass,especially in the subsoils(20-100 cm).Additionally,SOC,POC,and MAOC showed strong positive correlations with microbial necromass but exhibited weak associations with plant and litter C pools.The MAOC/POC ratio correlated strongly with the ratio of fungal necromass carbon(FNC)vs.bacterial necromass carbon(BNC).These results reveal that microbial-especially fungal-necromass may underpin the soil C stability and ecosystem C persistence of mature pine reforestations.Therefore,accurately predicting the long-term C sequestration of mature reforestation requires a mechanistic understanding that integrates both SOC stability and microbial necromass dynamics.
基金supported by the National Natural Science Foundation of China(No.62205030)the R&D Program of Beijing Municipal Education Commission(No.KM202211232019).
摘要To achieve continuous demodulation,high precision,and high resolution in the C-band,this paper designs,simulates and prepares a 30-channel array waveguide grating(AWG)based on a silicon dioxide planar optical circuit for fiber Bragg grating(FBG)interrogation and couples the prepared AWG with a photodetector array using hybrid integration technology.The test results indicate that the AWG has a good transmission spectrum,a 3 dB bandwidth of 2.15 nm,an insertion loss of approximately 3.6–4.2 dB,and crosstalk of less than−30 dB.The FBG interrogation system can achieve continuous demodulation in the dynamic range of 1521–1569 nm,and realize continuous demodulation in the C-band with a wavelength resolution of 1 pm and a demodulation accuracy of 5.8 pm.This demodulation method provides an optimization direction for researching FBG interrogation systems based on AWGs.
摘要We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China".We apologized for the inconvenience caused by this error.
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
摘要Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
基金supported by the National Key R&D Program of China(No.2022YFB4401400)the Songshan Laboratory(No.221100211100).
摘要In recent years,mature advanced packaging technologies have increasingly enabled the integration of multiple small dies into larger chips,while retaining chip-scale density and high-bandwidth interconnects.To address the inefficiencies of manual design and the challenges of heterogeneous optimization in wafer-scale chip(WSC)development,we systematically explore key factors in WSC architecture design.We integrate chip layout,operator mapping,and hardware–software codesign,and formulate the WSC architecture exploration problem as a multi-objective optimization task.First,we establish a hierarchical architecture model for WSCs,unifying the quantification of core constraints and interconnect topology constraints;second,we propose a hierarchical multi-objective collaborative optimization framework to jointly optimize physical constraints and task mapping communication patterns;finally,we develop a WSC optimizer toolchain that supports mixed-granularity simulation and generates optimal configurations for representative workloads.Experimental results demonstrate that compared with traditional computer architectures,the optimized architectures generated by our WSC optimizer achieve up to a 22×throughput improvement and a 5×latency reduction in application domains,such as cryptographic decryption and signal processing.