期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到2,130篇文章
< 1 2 … 107 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Systematic review of mitochondrial dysfunction and oxidative stress in aging:A focus on neuromuscular junctions 认领 引用
1
作者 Senlin Chai Ning Zhang +8 位作者 Can Cui Zhengyuan Bao Qianjin Wang Wujian Lin Ronald Man Yeung Wong Sheung Wai Law Rebecca Schönmehl Christoph Brochhausen Wing Hoi Cheung 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第5期1947-1960,共14页
Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pa... Mitochondrial dysfunction and oxidative stress are widely regarded as primary drivers of aging and are associated with several neurodegenerative diseases.The degeneration of motor neurons during aging is a critical pathological factor contributing to the progression of sarcopenia.However,the morphological and functional changes in mitochondria and their interplay in the degeneration of the neuromuscular junction during aging remain poorly understood.A defined systematic search of the Pub Med,Web of Science and Embase databases(last accessed on October 30,2024)was conducted with search terms including'mitochondria','aging'and'NMJ'.Clinical and preclinical studies of mitochondrial dysfunction and neuromuscular junction degeneration during aging.Twentyseven studies were included in this systematic review.This systematic review provides a summary of morphological,functional and biological changes in neuromuscular junction,mitochondrial morphology,biosynthesis,respiratory chain function,and mitophagy during aging.We focus on the interactions and mechanisms underlying the relationship between mitochondria and neuromuscular junctions during aging.Aging is characterized by significant reductions in mitochondrial fusion/fission cycles,biosynthesis,and mitochondrial quality control,which may lead to neuromuscular junction dysfunction,denervation and poor physical performance.Motor nerve terminals that exhibit redox sensitivity are among the first to exhibit abnormalities,ultimately leading to an early decline in muscle strength through impaired neuromuscular junction transmission function.Parg coactivator 1 alpha is a crucial molecule that regulates mitochondrial biogenesis and modulates various pathways,including the mitochondrial respiratory chain,energy deficiency,oxidative stress,and inflammation.Mitochondrial dysfunction is correlated with neuromuscular junction denervation and acetylcholine receptor fragmentation,resulting in muscle atrophy and a decrease in strength during aging.Physical therapy,pharmacotherapy,and gene therapy can alleviate the structural degeneration and functional deterioration of neuromuscular junction by restoring mitochondrial function.Therefore,mitochondria are considered potential targets for preserving neuromuscular junction morphology and function during aging to treat sarcopenia. 展开更多
关键词 aging mitochondrial dysfunction neuromuscular junction oxidative stress sarcopenia systematic review
暂未订购 下载PDF
Acupuncture and moxibustion for chronic eczema:A systematic review 认领 引用
2
作者 Yi-xi ZHAO Can ZHANG +1 位作者 Yan-yan ZHAO Sheng CHEN 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第2期149-168,共20页
Objective To systemically evaluate the effectiveness and safety of acupuncture and moxibustion for chronic eczema,and to provide evidence for acupuncture and moxibustion in the treatment of chronic eczema.Methods Rand... Objective To systemically evaluate the effectiveness and safety of acupuncture and moxibustion for chronic eczema,and to provide evidence for acupuncture and moxibustion in the treatment of chronic eczema.Methods Randomized controlled trials(RCTs)were retrieved from PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),VIP database,Wanfang database and China Biology Medicine disc(CBM),from the inception of the database to April 23,2025.The control group were sham acupuncture and moxibustion,no treatment,or conventional western medication.The intervention group were acupuncture and moxibustion therapy or acupuncture and moxibustion on the basis of the interventions as the control group.Meta-analysis was performed by using RevMan5.4.0 software according to Cochrane systematic evaluation method.Results Ultimately,53 RCTs were included.The results of the meta-analysis showed that compared with sham acupuncture and moxibustion,no treatment,or conventional western medication,acupuncture and moxibustion treatment for eczema area and severity index(EASI)score(mean difference[MD]=−2.23,95%confidence interval[CI]−2.61 to−1.85;P<0.00001),visual analogue scale(VAS)score(standardized mean difference[SMD]=−1.45,95%CI−2.04 to−0.87;P<0.00001),dermatology life quality index(DLQI)score(MD=−2.36,95%CI−3.25 to−1.48;P<0.00001),immunoglobulin E(IgE)(SMD=−1.26,95%CI−2.46 to−0.05;P=0.04),the overall response rate(odds ratio[OR]=4.58,95%CI 3.84 to 5.46;P<0.00001)and the recurrence rate(OR=0.14,95%CI 0.09 to 0.21;P<0.00001)were all better than those in the control group,and there were no severe adverse events reported.Conclusion Acupuncture and moxibustion can reduce the lesion area and severity of the patients with chronic eczema,effectively alleviate pruritus,improve the quality of life and decrease serum IgE.This therapy owns high overall response rate with low recurrence rate,and without severe adverse events,which is associated with a favorable long-term prognosis. 展开更多
关键词 Acupuncture Moxibustion Chronic eczema Therapeutic effect Systematic review Meta-analysis
暂未订购 下载PDF
Predictors of early cerebrovascular events after transcatheter aortic valve replacement:a systematic review and meta-analysis 认领 引用
3
作者 Yi ZHANG Ying ZHANG +2 位作者 Yi-Jun YAO Tian-Yuan XIONG Mao Chen 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2026年第5期309-316,共8页
Background Early cerebrovascular events(CVEs)following transcatheter aortic valve replacement(TAVR)are severe complications,but effective methods for predicting and preventing these events have not been well establish... Background Early cerebrovascular events(CVEs)following transcatheter aortic valve replacement(TAVR)are severe complications,but effective methods for predicting and preventing these events have not been well established.A systematic review and meta-analysis were performed to identify significant predictors of early CVEs post-TAVR.Methods MEDLINE/Embase databases were searched for articles published between December 2015 and April 2023.Original studies evaluating predictors of CVEs within 30 days post-TAVR after adjusting for confounders were included.Two investigators independently extracted data following the PRISMA statement.Meta-analyses of multivariable data were performed using Der Simonian and Laird random-effects models,with results expressed as odds ratios(ORs)and 95%confidence intervals(CIs).Robustness was assessed via Harbord's test,nonparametric trim-and-fill analysis,leave-one-out sensitivity analysis,the QUIPS quality assessment tools,meta-regression,and subgroup analyses.Results Among the 74 included studies,multivariate meta-analyses identified 11 predictors of early CVEs,including 9 patientlevel predictors-a CHA2DS2-VASc≥5,no prior heart failure,diabetes,isolated aortic stenosis,carotid artery stenosis,peripheral artery disease,advanced age,New York Heart Association class≥Ⅲ,and significant left ventricular outflow tract calcificationand 2 procedure-level predictors:the absence of cerebral embolization protection and post-dilation.Additionally,10 patient-level factors and 5 procedure-level factors were not associated with early CVEs,although significant heterogeneity was observed in most analyses.Conclusions This study identified multiple patient-level and procedure-level factors associated or not associated with early CVEs after TAVR.These findings support the development of a comprehensive risk prediction model that can accommodate diverse patient populations and evolving procedural techniques,thereby enhancing clinical risk management strategies. 展开更多
关键词 Meta analysis Transcatheter Aortic Valve Replacement transcatheter aortic valve replacement tavr cerebrovascular events cves following Predictors CHA DS VASc Score systematic review Early Cerebrovascular Events
暂未订购 下载PDF
Association between periodontal disease and prostatic disease:a systematic review and meta-analysis of observational studies 认领 引用
4
作者 Qiang Li Lan Wu +5 位作者 Yi Zhang Di Huang Song Ou-Yang Jia-Yu Yang Bing-Hui Li Xian-Tao Zeng 《The Canadian Journal of Urology》 SCIE 2026年第1期7-20,共14页
Objective:Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases,which prompted us to explore the potential association.T... Objective:Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases,which prompted us to explore the potential association.To evaluate whether periodontal disease is associated with an increased risk of prostatic disease,including prostate cancer,benign prostatic hyperplasia(BPH),and prostatitis.Methods:A systematic search of observational studies concerning the relationship between periodontal disease and prostatic disease was performed in online databases PubMed,Embase,Web of Science,Scopus,CENTRAL,CNKI,and WanFang.Searches were conducted from database inception to 31 July 2025.Pooled hazard ratio(HR)or odds ratio(OR)with 95%confidence intervals(CIs)were synthesized.Subgroup analysis was used to detect the origin of heterogeneity,sensitivity analysis was employed to evaluate the robustness of the results,and publication bias analyses were also performed.R software was used to perform statistical analyses.Results:Sixteen studies that met the preset criteria were included in this study.In the pooled analysis,periodontal disease was associated with increased risk of prostate cancer(HR=1.23,95%CI:1.16-1.29,p<0.001)or BPH(OR=1.55,95%CI:1.41-1.70,p<0.001).Sensitivity analysis confirmed the robustness of the results.No obvious publication biaswas found in the meta-analysis.Only one cohort study reported that chronic periodontitis increases the risk of prostatitis(HR=2.521,95%CI:1.685-4.005,p<0.001).The effect of periodontal treatment on prostatic disease is still unclear.Conclusions:The systematic review and meta-analysis identified an observational association between periodontal disease and increased risks of prostate cancer and BPH.Because all included studies were observational,these results indicate association rather than causation,and further prospective and mechanistic studies are required to clarify temporality and causality. 展开更多
关键词 Periodontal diseases prostatic diseases prostatic neoplasms prostatic hyperplasia systematic review meta-analysis
暂未订购 下载PDF
Artificial intelligence assisted 3D in the robotic urooncology?A systematic review and narrative synthesis of current applications,challenges and future directions 认领 引用
5
作者 Bara Barakat Bilal Al-Absi +3 位作者 Boris Hadaschik Christian Rehme Samer Schakaki Joerg Bauer 《The Canadian Journal of Urology》 SCIE 2026年第1期105-116,共12页
Background:Artificial intelligence(AI)-assisted threedimensional(3D)surgical platforms,integrated with augmented reality,have the potential to improve intraoperative anatomical recognition and provide surgeons with an... Background:Artificial intelligence(AI)-assisted threedimensional(3D)surgical platforms,integrated with augmented reality,have the potential to improve intraoperative anatomical recognition and provide surgeons with an immersive,dynamic operating environment during urooncological procedures.This review aims to examine the current applications of AI in robotic uro-oncology,with a particular focus on its role in facilitating intraoperative navigation during complex surgeries.Methods:A systematic literature search was performed across PubMed,the National Library of Medicine,MEDLINE,the Cochrane Central Register of Controlled Trials(CENTRAL),ClinicalTrials.gov,and Google Scholar to identify relevant studies published up to July 2025.The search strategy incorporated a predefined set of keywords,including AI,machine learning,radical prostatectomy(RP),robotic-assisted radical prostatectomy(RARP),robotassisted partial nephrectomy(RAPN),and robot-assisted radical cystectomy(RARC).Only clinical trials,full-text peer-reviewed publications,and original research articles were included.Studies were eligible for inclusion if they evaluated or described applications of AI in RARP,RAPN,or RARC.Results:Technological advancements have substantially transformed the field of uro-oncologic surgery.In particular,AI and AI-assisted intraoperative navigation in RARP demonstrate considerable potential to objectively assess surgical performance and predict clinical outcomes.In RAPN,the adoption of preoperative,interactive 3D virtualmodels for surgical planning has influenced surgical decisions,thus,enhanced precision in resection planning correlates with superior nephron-sparing outcomes and optimized selective clamping.AI applications in RARC,techniques such as augmented reality(AR)can overlay critical information on the surgical field,by facilitating navigation through complex anatomical planes and enhancing identification of critical structures.Conclusion:AI appears to enhance robotic uro-oncologic procedures by increasing operative precision and supporting individualised surgical treatment strategies. 展开更多
关键词 artificial intelligence robot-assisted surgery machine learning deep learning automatic three-dimensional surgical navigation intuitive surgical systematic review
暂未订购 下载PDF
Abortion prevalence and its related factors in Iran:A systematic review and meta-analysis 认领 引用
6
作者 Roghaye Ahangari Abolfazl Mohammadbeigi +1 位作者 Azadeh Asgarian Seyedeh Sakineh Latifi-Rostami 《Asian pacific Journal of Reproduction》 CAS 2026年第3期124-131,共8页
Objective:To estimate the pooled prevalence rate of different types of abortion and the most important related factors of abortion in Iran based on a systematic review and meta-analysis.Methods:This systematic review ... Objective:To estimate the pooled prevalence rate of different types of abortion and the most important related factors of abortion in Iran based on a systematic review and meta-analysis.Methods:This systematic review and meta-analysis was conducted on the Iranian studies during the February 1,2012 to December 31,2024.Abortion prevalence and its influencing factors were evaluated.Relevant keywords were used to find eligible studies in Web of Science,PubMed,Google Scholar,Scopus,Science-Direct and SID databases.Due to high heterogeneity in included studies,random-effects model was utilized to estimate the pooled estimated of abortion and its subgroups.Results:Out of 231 reviewed articles,only 11 articles on 24429 women were finally included.The pooled prevalence of induced abortion,spontaneous abortion,legal abortion and overall abortion was estimated as 7.65%(95%CI 4.24 to 11.95),5.92%(95%CI 0.24 to 18.32),1.66%(95%CI 0.83 to 2.76)and 7.23%(95%CI 1.07 to 18.22),respectively.Conclusions:Abortion is a worldwide major public health problem even in Iran and related to different socioeconomic and psychosocial factors.Its prevalence in Iran is high and it remains as reproductive health concern in Iran due to low fertility rate and oncoming up down population growth. 展开更多
关键词 Abortion Miscarriage Risk factors Prevalence Iran Systematic review
暂未订购 下载PDF
Correlation between non-alcoholic fatty liver disease and erectile dysfunction:A systematic narrative review 认领 引用
7
作者 Yan-Fei He Ning Bian +6 位作者 Huan-Zhi Wang Xiao-Dong Hu Jun-Qiang Liu Shuang-Feng Lu Ni Wu Qin-Tong He Hu-Ming Li 《World Journal of Hepatology》 2026年第4期190-199,共10页
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,as well as a growing public health concern.Erectile dysfunction(ED)is one of the most common sexual dysfunctions in... BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,as well as a growing public health concern.Erectile dysfunction(ED)is one of the most common sexual dysfunctions in men.Currently,clinical research on the relationship between NAFLD and ED is limited.AIM To systematically review and narrative synthesize the existing evidence on the association between NAFLD and ED,and to elucidate potential underlying mechanisms.METHODS We conducted a comprehensive search of various electronic databases to identify original observational studies investigating the association between NAFLD and ED.However,due to significant heterogeneity among the included studies and the limited number of eligible investigations,we opted for a narrative synthesis instead of a meta-analysis.RESULTS A total of seven observational studies,involving 4442 participants(2043 of whom had NAFLD),were included in the analysis.The evidence consistently indicates a significant positive association between NAFLD and ED.Key influencing factors identified across the studies included age,components of metabolic syndrome,insulin resistance,serum testosterone levels,and psychological factors such as anxiety.CONCLUSION Existing evidence indicates a strong correlation between NAFLD and ED.The strength of this association is influenced by various factors,including age,insulin resistance,testosterone levels,and anxiety.NAFLD is an important risk factor for ED.Further high-quality studies are needed to confirm this relationship and explain its underlying mechanisms. 展开更多
关键词 Non-alcoholic fatty liver disease Erectile dysfunction Chronic liver diseases Sexual dysfunction Metabolic syndrome Insulin resistance Systematic review Narrative synthesis
暂未订购 下载PDF
Investigating the Mental Health of Left-Behind Children in China’s Rural Areas:A Systematic Review Approach 认领 引用
8
作者 Jian Li Yide Chen +1 位作者 Xinyi Zhao Eryong Xue 《International Journal of Mental Health Promotion》 2026年第3期1-25,共25页
Background:The mobility of people in rural areas may lead to more and more left-behind children(LBC)appearing,and being an LBC brings a lot of risks to mental health,which could greatly hinder children’s development ... Background:The mobility of people in rural areas may lead to more and more left-behind children(LBC)appearing,and being an LBC brings a lot of risks to mental health,which could greatly hinder children’s development and undermine their happiness and safety in life.Previous scholars have conducted plenty of studies that focused on Chinese rural LBCs’mental health issues,such as what they exactly look like and some potential factors,but there remains a paucity of reviews about the relationship among certain mental health issues.We will try to figure out how the most common mental health issues of LBC in China’s rural areas correlate with each other,as well as their related factors.Methods:In this study,we used a systematic review approach to analyze 35 publications from Web of Science and EBSCO(to August 2025),followed by the sorting standards of Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2020.Results:By mainly using quantitative techniques,we found that Chinese rural LBC are more likely to have mental health issues than children who have no experience of being left behind,and they often suffer from depression,social anxiety,internet addiction,and suicidal ideation.These four mental health issues share influencing factors and positively correlate with each other.We also found that Chinese rural LBCs are somewhat resilient towards the risk factors of mental health issues,and national or social policies and interventions can really help them a lot.Conclusion:For Chinese rural LBC,there are important relationships among the common psychological disorders they often suffer,along with multiple factors that affect their mental health,which can help related scholars and practitioners pay attention to such mechanisms and think more comprehensively when they try to help the children who are left behind. 展开更多
关键词 Left-behind children rural area China mental health systematic review
暂未订购 下载PDF
Ferroptosis as a Translational Axis in Small Cell Lung Cancer:A Systematic Review of Redox Pathways and Precision Oncology Prospects 认领 引用
9
作者 Donatella Coradduzza Anna La Salvia +1 位作者 Giuseppe Fanciulli Maria Rosaria De Miglio 《Oncology Research》 SCIE 2026年第4期122-157,共36页
Background:An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer(SCLC).The systematic review aimed to summarize the characteristics of ferro... Background:An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer(SCLC).The systematic review aimed to summarize the characteristics of ferroptosis from its pathogenetic role to translational therapeutic implications in SCLC.Methods:This systematic review,registered in PROSPERO(CRD420251090058),followed PRISMA 2020 guidelines.Comprehensive research of PubMed,Scopus,and Web of Science was performed for studies published between January 2010 and July 2025 investigating ferroptosis mechanisms,genetic or pharmacological modulation,or molecular profiling in SCLC.Two reviewers independently performed data extraction and quality assessment.Results:Nineteen preclinical studies met the inclusion criteria.Key regulators included solute carrier family 7 member 11(SLC7A11),glutathione peroxidase 4(GPX4),ferroptosis suppressor protein 1(FSP1),and acyl-CoA synthetase long chain family member 4(ACSL4).The molecular subtypes of SCLC,achaete-scute homolog 1(ASCL1),neuronal differentiation 1(NEUROD1),POU class 2 homeobox 3(POU2F3),and Yes1 associated transcriptional regulator(YAP1)exhibit differential ferroptosis gene expressions,influencing therapeutic responsiveness.Non-neuroendocrine subtypes are more ferroptosis-prone,whereas neuroendocrine variants display enhanced antioxidant defenses.Ferroptosis induction also promotes immune activation through stimulator of interferon genes(STING)-mediated CD8+T-cell recruitment.Conclusions:Ferroptosis constitutes a promising therapeutic axis in SCLC.Integrating ferroptosis biomarkers into molecular stratification frameworks could refine patient selection and support precision oncology strategies,warranting further translational and clinical validation. 展开更多
关键词 Small cell lung cancer ferroptosis lipid peroxidation glutathione peroxidase 4 solute carrier family 7 member 11 molecular subtypes immunotherapy oxidative stress regulated cell death translational oncology systematic review
暂未订购 下载PDF
Factors associated with aseptic loosening after primary total hip arthroplasty:A systematic review and meta-analysis 认领 引用
10
作者 Guo-Qing Li Ji Zhang Yong Huang 《World Journal of Orthopedics》 2026年第1期149-163,共15页
BACKGROUND Aseptic loosening remains the leading cause of revision in primary total hip arthroplasty(pTHA).However,the literature demonstrates significant variability regarding the relative contributions of different ... BACKGROUND Aseptic loosening remains the leading cause of revision in primary total hip arthroplasty(pTHA).However,the literature demonstrates significant variability regarding the relative contributions of different factors.AIM To investigate the key determinants of aseptic loosening,we performed a systematic review and meta-analysis.METHODS A comprehensive search of PubMed,Web of Science,EMBASE,and the Cochrane Library was conducted,encompassing studies from database inception to January 1,2025.Meta-analyses were performed to evaluate factors associated with aseptic loosening following pTHA.Inclusion and exclusion criteria were systematically applied at each stage to ensure methodological transparency and reproducibility.Study quality was assessed using standardized categories.Pooled odds ratio(OR)with corresponding 95%confidence interval were calculated with random-or fixed-effects models to generate reliability estimates,and study heterogeneity was visualized using forest plots.Ten factors,categorized into patient-,surgeon-,and device-related domains,were reviewed and meta-analyzed.Funnel plot analysis demonstrated a relatively symmetrical distribution,suggesting minimal publication bias.RESULTS A meta-analysis of 20 studies(520789 participants)found a pooled prevalence of 1.96%.Significant risk factors for aseptic loosening after pTHA included elevated body mass index(OR=1.116,P<0.001),higher Charlson comorbidity index(OR=1.378,P<0.001),prosthesis-related factors(OR=1.497,P<0.001),and adverse lifestyles(OR=2.198,P=0.037).Protective factors were non-white race(OR=0.445,P<0.001)and favorable genetics(OR=0.723,P<0.001).Male sex increased risk(OR=1.232,P=0.016),while age and anatomy were not significant.Surgical expertise showed a slight protective effect(OR=1.048,P<0.001).A comprehensive understanding of the modifiable and non-modifiable factors contributing to aseptic loosening after pTHA requires consideration of patient-related factors,surgical expertise,and prosthesis characteristics.CONCLUSION The identification of these factors is critical for risk mitigation.High-risk patients should receive targeted counseling regarding individualized profiles.Further studies are warranted to establish clearer causal relationships and identify additional contributing factors. 展开更多
关键词 Factors Aseptic loosening Primary total hip arthroplasty Systematic review Meta-analysis
暂未订购 下载PDF
Electroacupuncture for the treatment of ischemic stroke:A preclinical meta-analysis and systematic review 认领 引用 被引量：4
11
作者 Guohui Yang Chong Guan +7 位作者 Meixi Liu Yi Lin Ying Xing Yashuo Feng Haozheng Li Yi Wu Nianhong Wang Lu Luo 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1191-1210,共20页
Stroke remains a leading cause of death and disability worldwide,and electroacupuncture has a long history of use in stroke treatment.This meta-analysis and systematic review aimed to evaluate the efficacy of electroa... Stroke remains a leading cause of death and disability worldwide,and electroacupuncture has a long history of use in stroke treatment.This meta-analysis and systematic review aimed to evaluate the efficacy of electroacupuncture and explore its potential mechanisms in animal models of ischemic stroke.The PubMed,EMBASE,Web of Science,CENTRAL,and CINAHL databases were comprehensively searched up to May 1,2024.This review included articles on preclinical investigations of the efficacy and mechanisms of electroacupuncture in treating ischemic stroke.Data from 70 eligible studies were analyzed in Stata 18.0,using a random-effects model to calculate the standardized mean difference(Hedge’s g).The risk of bias was assessed using RevMan 5.4 software,and the quality of evidence was rated according to the Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)system.Subgroup analyses were conducted to test the consistency of the results and sensitivity analyses were used to assess their robustness.The quality assessment revealed that most studies adequately handled incomplete data and selective reporting.However,several methodological limitations were identified:only 4 studies demonstrated a low risk of allocation concealment,26 achieved a low risk of outcome assessment bias,and 9 had a high risk of randomization bias.Additionally,there was an unclear risk regarding participant blinding and other methodological aspects.The GRADE assessment rated 12 outcomes as moderate quality and 6 as low quality.The mechanisms of electroacupuncture treatment for ischemic stroke can be categorized as five primary pathways:(1)Electroacupuncture significantly reduced infarct volume and apoptotic cell death(P<0.01)in ischemic stroke models;(2)electroacupuncture significantly decreased the levels of pro-inflammatory factors(P<0.01)while increasing the levels of anti-inflammatory factors(P=0.02);(3)electroacupuncture reduced the levels of oxidative stress indicators(P<0.01)and enhanced the expression of antioxidant enzymes(P<0.01);(4)electroacupuncture significantly promoted nerve regeneration(P<0.01);and(5)electroacupuncture influenced blood flow remodeling(P<0.01)and angiogenesis(P<0.01).Subgroup analyses indicated that electroacupuncture was most effective in the transient middle cerebral artery occlusion model(P<0.01)and in post-middle cerebral artery occlusion intervention(P<0.01).Dispersive waves were found to outperform continuous waves with respect to neuroprotection and anti-inflammatory effects(P<0.01),while scalp acupoints demonstrated greater efficacy than body acupoints(P<0.01).The heterogeneity among the included studies was minimal,and sensitivity analyses indicated stable results.Their methodological quality was generally satisfactory.In conclusion,electroacupuncture is effective in treating cerebral ischemia by modulating cell apoptosis,oxidative stress,inflammation,stroke-induced nerve regeneration,blood flow remodeling,and angiogenesis.The efficacy of electroacupuncture may be influenced by factors such as the middle cerebral artery occlusion model,the timing of intervention onset,waveform,and acupoint selection.Despite the moderate to low quality of evidence,these findings suggest that electroacupuncture has clinical potential for improving outcomes in ischemic stroke. 展开更多
关键词 apoptosis angiogenesis electroacupuncture ischemic stroke inflammation metaanalysis nerve regeneration oxidative stress randomized controlled trial systematic review
暂未订购 下载PDF
Staging laparoscopy in esophagogastric junction cancer:Systematic review and meta-analysis 认领 引用 被引量：1
12
作者 Roberto de la Plaza Llamas Diego Ribera Díaz +5 位作者 Paula Betancor Díaz Daniel A Díaz Candelas Raquel A Latorre-Fragua Ludovica Gorini Rodrigo Arellano González Ignacio A Gemio del Rey 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期376-394,共19页
BACKGROUND Staging laparoscopy(SL)is a valuable tool for detecting occult peritoneal or hepatic metastases in patients with gastroesophageal junction(GEJ)cancer,especially when imaging suggests resectability.Despite a... BACKGROUND Staging laparoscopy(SL)is a valuable tool for detecting occult peritoneal or hepatic metastases in patients with gastroesophageal junction(GEJ)cancer,especially when imaging suggests resectability.Despite advances in cross-sectional imaging methodologies such as computed tomography,positron emission tomography/computed tomography and endoscopic ultrasound,these techniques may miss low-volume or superficial peritoneal disease.Early identification of metastatic spread through SL can avoid unnecessary surgery,reduce morbidity,and improve treatment planning.However,its use in GEJ tumors-particularly Siewert types Ⅰ and Ⅱ-remains debated.Understanding the diagnostic performance(DP)of SL is essential for optimizing staging strategies.AIM To evaluate the DP of SL in identifying abdominal metastatic disease in patients with clinically resectable GEJ tumors.METHODS Systematic review and meta-analysis in accordance with PRISMA 2020 guidelines.A comprehensive PubMed search was performed up to March 29,2024,using Medical Subject Headings terms related to GEJ,laparoscopy,and cancer staging.Inclusion criteria:Studies assessing SL in patients with GEJ tumors.Primary outcome was the rate of upstaging to stage Ⅳ due to peritoneal or hepatic metastases.Secondary outcomes included details on techniques,patient characteristics,and procedural factors.Risk of bias was evaluated using Risk of Bias in Non-randomised Studies of Interventions and certainty of evidence with Grading of Recommendations,Assessment,Development and Evaluation.RESULTS Eighteen studies involving 1591 patients were included.SL upstaged 22%of patients(95%confidence interval:17-27)to stage Ⅳ due to occult metastatic disease.The pooled positivity rates were positive peritoneal malignancy(17.5%),peritoneal carcinomatosis(13%),malignant peritoneal cytology(9%),and hepatic metastases(9.2%).SL avoided unnecessary surgery in 19.8%of cases.Subgroup analysis revealed consistent performance in Siewert Ⅱ tumors(DP=13%,I2=0),while in Siewert Ⅰ tumors it was more heterogeneous(DP=18%,I2=93.7%).Only five studies reported complications,mostly minor,with no procedure-related mortality.No comorbidities,carcinomatosis scoring,conversion to open surgery,complications of follow-up,readmissions,postoperative length of stay,or delay in initiating neoadjuvant therapy were recorded.CONCLUSION SL improves staging accuracy in GEJ cancers,especially Siewert Ⅱ.Despite heterogeneity and limited data stratification,SL may guide therapeutic decisions and help avoid unnecessary or futile surgeries. 展开更多
关键词 Esophagogastric junction Laparoscopy Neoplasm staging Staging laparoscopy Systematic review Meta-analysis
暂未订购 下载PDF
The evolution and current landscape of AI in geographical research:A large-scale systematic review 认领 引用 被引量：1
13
作者 Chenjin An Jianghao Wang Chenghu Zhou 《Geography and Sustainability》 CSCD 2026年第1期1-14,共14页
With the rapid advancement of Artificial Intelligence(AI)technologies,its applications have become increasingly widespread across various aspects of geography,offering unprecedented analytical capabilities across disc... With the rapid advancement of Artificial Intelligence(AI)technologies,its applications have become increasingly widespread across various aspects of geography,offering unprecedented analytical capabilities across disciplinary boundaries.Despite this revolutionary potential,a comprehensive understanding of the current research landscape and development trajectory of AI in geographical sciences remains limited.To fill this gap,we conducted a large-scale systematic review based on 400,000 geographical publications published from 1990 to 2023.We utilized large language model(LLM)prompt engineering,topic modeling and other natural language processing techniques to analyze the publications.Our findings reveal that AI applications constitute 8.1% of geographical research,with publication volume having increased 20-fold over three decades.Both China and the United States have been the leading contributors to AI-driven geographical studies,together accounting for 62.78% of all publications in this field.Notably,more than half of the studies used traditional machine learning methods.Among the various geographical topics,remote sensing applications and spatial data analysis emerged as the most extensively explored areas using AI techniques,with image feature extraction being the topic with the deepest level of adoption and most significant ongoing impact of AI methods.This systematic review provides critical insights into the integration trajectory of AI within geographical sciences,establishing a foundation for identifying emerging research opportunities and enhancing our understanding of AI’s transformative role in advancing geographical knowledge. 展开更多
关键词 Geography Artificial intelligence LLM Systematic review
暂未订购 下载PDF
Moxibustion for chemotherapy-induced myelosuppression:A systematic review and meta-analysis 认领 引用
14
作者 Dan XUE Rong-lin LAN +2 位作者 Hua-tao HU Yun-bin ZHANG Xian-bao HUANG 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2026年第1期18-28,共11页
Objective:To evaluate the effectiveness and safety of moxibustion for chemotherapy-induced myelosuppression.Methods:The randomized controlled trials of moxibustion for chemotherapy-induced myelosuppression were search... Objective:To evaluate the effectiveness and safety of moxibustion for chemotherapy-induced myelosuppression.Methods:The randomized controlled trials of moxibustion for chemotherapy-induced myelosuppression were searched in PubMed,Cochrane Library,Web of Science,Embase,China Journal Full-text Database,SinoMed,Wanfang Data Knowledge Service Platform,and VIP Chinese Journal Service Platform,from the inception of each database to July 30,2024.RevMan5.3 and Stata18.0 were used for meta-analysis,and the quality of included literature was evaluated by Cochrane Risk of Bias(RoB)assessment tool.Results:A total of 19 articles were included.Moxibustion can increase white blood cell count(MD=1.06,95%CI:0.45-1.68,P=0.0007),platelet count(MD=32.02,95%CI:16.33-47.72,P<0.00001),hemoglobin content(MD=5.57,95%CI:1.61-9.53,P=0.006)and neutrophil count(MD=1.20,95%CI:0.94-1.45,P<0.00001).Moxibustion could alleviate chemotherapy-induced myelosuppression(RR=0.70,95%CI:0.56-0.86,P=0.0007),reduced the incidences of leukopenia(RR=0.39,95%CI:0.26-0.59,P<0.000001)and thrombocytopenia(RR=0.33,95%CI:0.21-0.53,P<0.000001),and can improve the score of quality of life(MD=0.55,95%CI:0.32-0.79,P<0.00001).Conclusion:Moxibustion can increase the white blood cell count,platelet count,hemoglobin content and neutrophil count of patients after chemotherapy,alleviate myelosuppression,and the incidences of leukopenia and thrombocytopenia induced by chemotherapy,and improve the quality of life.Moxibustion is effective and safe for chemotherapy-induced myelosuppression.However,due to the relatively low quality of included studies,there are certain limitations.More high-quality studies are needed in the future to provide more reliable evidence-based basis for clinical practice. 展开更多
关键词 Myelosuppression Post-chemotherapy Moxibustion Tumor Systematic review Meta analysis
暂未订购 下载PDF
Healthcare professionals’perspectives on disclosure of diagnosis and related issues in childhood cancer:A mixed methods systematic review 认领 引用
15
作者 Run Xie Xiaoyan Huang +4 位作者 Yiran Du Ying Gu Qiongfang Kang Hongsheng Wang Daqian Zhu 《International Journal of Nursing Sciences》 CSCD 2026年第1期96-104,I0006,共9页
Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of... Objectives This review aimed to systematically synthesize the available research on the disclosure of diagnosis and related issues in childhood cancer from the perspectives of healthcare professionals,with the goal of informing the optimization of disclosure processes and meeting the communication needs of affected families.Methods In accordance with the Joanna Briggs Institute(JBI)methodology for mixed methods systematic reviews,the convergent segregated approach was used in this review.Articles were retrieved from 11 databases,including PubMed,Web of Science,CINAHL,CENTRAL,Embase,Ovid/Medline,PsycINFO,PsycArticles,Scopus,ERIC,and China National Knowledge Infrastructure(CNKI).The quality of the selected articles was assessed using the Mixed Method Appraisal Tool(MMAT).The review protocol was registered on PROSPERO(CRD42024542746).Results A total of 21 studies from 10 countries were included.Their methodological quality was generally medium to high,with MMAT scores ranging from 60%to 100%.The synthesis yielded three core themes:1)the spectrum of professional and societal attitudes toward disclosure;2)the dynamic practices of navigating disclosure amid uncertainty,including timing and environment,stakeholders,and content of disclosure;and 3)factors influencing disclosure,including children’s,parental,healthcare professionals’,and socio-cultural factors.Conclusions This review synthesized the perspectives and experiences of healthcare professionals regarding disclosure in childhood cancer,highlighting the complexity and multidimensional nature of this process in clinical practice.Future research should further investigate the experiences and needs of children and their parents,explore cultural variations in disclosure practices,develop context-appropriate assessment tools,and construct multidimensional intervention strategies to enhance the humanistic care and professional effectiveness of the disclosure process. 展开更多
关键词 Communication Cancer Disclosure Healthcare professionals Mixed methods Pediatric Systematic review
暂未订购 下载PDF
Systematic explorations for the effect of nitric acid on radiolysis of TODGA/kerosene:extraction behavior and DFT investigations for the complexation of lanthanides 认领 引用
16
作者 Jia-Wei Zheng Shu-Yi Yang +2 位作者 Hao Wu Yan Wu Yue-Zhou Wei 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2026年第5期264-277,共14页
N,N,N',N'-tetraoctyl diglycolamide(TODGA)is a potential extractant for the co-extraction of lanthanides and actinides in high-level liquid waste.In this study,the radiolysis and extraction properties of TODGA ... N,N,N',N'-tetraoctyl diglycolamide(TODGA)is a potential extractant for the co-extraction of lanthanides and actinides in high-level liquid waste.In this study,the radiolysis and extraction properties of TODGA in kerosene solvents contacted with the aqueous phase of varying HNO3 concentrations were systematically investigated,and the complexation mechanism was analyzed in conjunction with density functional theory(DFT)calculations.After γ-irradiation,the variation of TODGA concentration was detected,and the variation trends in the relative content of radiolysis products(RPs)with sample type and absorbed dose were demonstrated.Results indicated that the breaking of the amide bond,ether bond,and Camide-Cetherbond was the primary radiolysis routes.The aqueous-phase precipitate was studied as a potential new mode of TODGA radiolysis in ultrapure water aqueous phase.Moreover,TODGA/kerosene exhibited excellent extraction capabilities for lanthanides even after absorbing 100 kGy,and HNO3 can maintain a portion of TODGA's extraction capacity.The DFT method was applied to calculate and evaluate the complexing ability of TODGA and some of its RPs toward lanthanides.The results revealed that the complexing ability of TODGA for Ce(Ⅲ),Eu(Ⅲ),and Dy(Ⅲ)was enhanced successively,and the complexing ability of the RPs with intact oxygen-containing structures could not be neglected. 展开更多
关键词 TODGA Kerosene Systematic research Radiolysis product Extraction DFT calculation
暂未订购 下载PDF
Evaluating acupuncture as a therapeutic intervention for post-COVID-19 olfactory dysfunction:a systematic review and pilot study 认领 引用
17
作者 Dongjue Wei Choryin Leung +9 位作者 Alan Yatlun Wong Shu Yang Peipei Du Yiping Wong Bacon FL Ng Rowena Wong Ka Ming Yau Hungwai Cho Chifung Choy Lidan Zhong 《Acupuncture and Herbal Medicine》 CAS CSCD 2026年第1期105-118,共14页
Objective:Olfactory dysfunction(OD)is a common and persistent symptom of coronavirus disease 2019(COVID-19)for which effective treatments remain limited.Acupuncture,widely used in Chinese medicine for olfactory disord... Objective:Olfactory dysfunction(OD)is a common and persistent symptom of coronavirus disease 2019(COVID-19)for which effective treatments remain limited.Acupuncture,widely used in Chinese medicine for olfactory disorders has uncertain efficacy in post-COVID-19 OD.Therefore,in this study,we aimed to explore the feasibility and preliminary efficacy of acupuncture in patients with post-COVID-19 OD.Methods:This study was a dual-phased study.Phase I involved a systematic review conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,encompassing eight databases.Phase II consisted of a pilot randomized controlled trial(RCT)enrolling 25 patients with moderate to severe post-COVID-19 OD.Participants were randomly assigned to receive either real(group A)or sham(group B)acupuncture.The intervention included eight sessions over 4 weeks,with assessments at baseline,post-cycle 1,2-week washout,post-cycle-2 treatment,and 2-week follow-up.The primary outcome was the change in scores on the 12-item Assessment of Self-Reported Olfactory Functioning and Quality of Life(ASOF).Secondary outcomes included the short version of the Questionnaire of Olfactory Disorders-Negative Statements(sQOD-NS)and the traditional Chinese version of the University of Pennsylvania Smell Identification Test(UPSIT-TC).Results:The systematic review identified 22 studies(15 case reports,seven RCTs)suggesting that acupuncture may positively influence olfactory function.In the pilot RCT,no significant baseline differences were observed between groups.Group A showed steady improvement across all ASOF domains during Cycle 1(SOC,mean=5.86;SRP,mean=3.26;ORQ,mean=3.98),with slight declines during cycle 2 and 2-week follow-up,though scores remained above baseline.Post-cycle 1,group A showed higher mean SOC and ORQ scores compared with group B(7.00 vs.4.67;3.98 vs.3.39).Improvements in secondary outcomes were also more pronounced in group A,whereas group B showed minimal changes.Conclusion:Acupuncture appears to be a safe and potentially effective treatment for post-COVID-19 OD,warranting validation through larger clinical trials. 展开更多
关键词 Acupuncture COVID-19 Olfactory dysfunction Pilot study Systematic literature review
暂未订购 下载PDF
Assessing Large Language Models for Early Article Identification in Otolaryngology—Head and Neck Surgery Systematic Reviews 认领 引用
18
作者 Ajibola B.Bakare Young Lee +2 位作者 Jhuree Hong Claus-Peter Richter Jonathan P.Kuriakose 《Health Care Science》 CSCD 2026年第1期19-28,共10页
Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Ja... Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Jabbour et al.2017,Wong et al.2018,and Wu et al.2021)were replicated using ChatGPTv3.5 and Bard.Outputs(author,title,publication year,and journal)were compared to the original references and cross-referenced with medical databases for authenticity and recall.Results:Several themes emerged when comparing Bard and ChatGPT across the three reviews.Bard generated more outputs and had greater recall in Wong et al.'s review,with a broader date range in Jabbour et al.'s review.In Wu et al.'s review,ChatGPT-2 had higher recall and identified more authentic outputs than Bard-2.Conclusion:Large language models(LLMs)failed to fully replicate peer-reviewed methodologies,producing outputs with inaccuracies but identifying relevant,especially recent,articles missed by the references.While human-led PRISMA-based reviews remain the gold standard,refining LLMs for literature reviews shows potential. 展开更多
关键词 artificial intelligence Bard ChatGPT large language models systematic review
暂未订购 下载PDF
Systematic Algebraic Method to Identify Clifford Operations for Quantum Error-Correction Codes 认领 引用
19
作者 Sheng-Chen Liu Yu-Xuan Lin +1 位作者 Ying-Xiang Wang Liang-You Peng 《Chinese Physics Letters》 SCIE EI CAS CSCD 2026年第4期122-141,共20页
In the domain of quantum error correction,a critical task involves identifying logical operations on logical qubits for various quantum codes.However,owing to the inherent complexity of many quantum codes,devising an ... In the domain of quantum error correction,a critical task involves identifying logical operations on logical qubits for various quantum codes.However,owing to the inherent complexity of many quantum codes,devising an efficient method to implement the desired logical operations utilizing the structure of these codes presents a significant challenge.In previous studies,several methods were used to realize specific logical operations for certain quantum codes;however,they usually do not work for other quantum codes. 展开更多
关键词 logical operations quantum codesdevising quantum codeshoweverthey systematic algebraic method quantum codeshoweverowing quantum error correctiona quantum co identifying logical operations logical qubits
暂未订购 下载PDF
The Frontier of Melanoma Treatment:Defeating Immunotherapy Resistance-A Systematic Review 认领 引用
20
作者 Kamila Mozga Olga Synowiecka +4 位作者 Igor Rydzyk Anna Marek Ewelina Wieczorek Alicja Petniak Paulina Gil-Kulik 《Oncology Research》 SCIE 2026年第2期90-108,共19页
Objectives:Immunotherapy based on immune checkpoint blockade(ICB)has become a key treatment for melanoma.However,the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop met... Objectives:Immunotherapy based on immune checkpoint blockade(ICB)has become a key treatment for melanoma.However,the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance.This study aims to collect the most recent information on melanoma immunotherapy,discuss potential strategies to overcome resistance to immunotherapy,and identify areas that require further analysis.Methods:To achieve this goal,scientific publications from 2021-2024 available in PubMed and Google Scholar databases were analyzed.The databases were searched using the following terms:“melanoma”,“immunotherapy”,“Immune Checkpoint Blockade”,and“immunoresistance”.Results:The results of preclinical and early-stage clinical research indicate the potential application of tank-binding kinase 1(TBK-1),fecal microbiota transplant(FMT),Toll-like Receptor 9(TLR9),lipid nanoparticles(LNPs)containing a stimulator of an interferon gene agonist(STING),BRAF inhibitors,Lymphocyte Activation Gene(LAG-3),T-Cell Immunoglobulin and ITIM Domain(TIGIT),and oncolytic viruses(OVs)as potential methods to enhance melanoma sensitivity to ICB.Discussion:To optimize immunotherapy,further research is needed to determine the detailed mechanisms of action,safety profiles,tolerability,and precise patient selection criteria for methods capable of overcoming melanoma’s immunoresistance. 展开更多
关键词 Melanoma immunotherapy immune checkpoint blockade(ICB) immunoresistance systematic review
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 107 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈