Tree-ring width(RW),density,elemental com-position,and stable carbon and oxygen isotope(δ13C,δ18O)are widely used as proxies to assess climate change,ecology,and environmental pollution;however,a specific pret...Tree-ring width(RW),density,elemental com-position,and stable carbon and oxygen isotope(δ13C,δ18O)are widely used as proxies to assess climate change,ecology,and environmental pollution;however,a specific pretreat-ment has been needed for each proxy.Here,we developed a method by which each proxy can be measured in the same sample.First,the sample is polished for ring width meas-urement.After obtaining the ring width data,the sample is cut to form a 1-mm-thick wood plate.The sample is then mounted in a vertical sample holder,and gradually scanned by an X-ray beam.Simultaneously,the count rates of the fluorescent photons of elements(for chemical characteriza-tion)and a radiographic grayscale image(for wood density)are obtained,i.e.the density and the element content are obtained.Then,cellulose is isolated from the 1-mm wood plate by removal of lignin,and hemicellulose.After producing this cellulose plate,cellulose subsamples are separated by knife under the microscope for inter-annual and intra-annual stable carbon and oxygen isotope(δ13C,δ18O)analysis.Based on this method,RW,density,elemental composition,δ13C,and δ18O can be measured from the same sample,which reduces sample amount and treatment time,and is helpful for multi-proxy comparison and combination research.展开更多
Based on the analysis of the correlation between the tree-ring width of Pinus tabulaeformis and the climate factors in the western Hedong sandy land of Ningxia, a conversion equation between the annual precipitation a...Based on the analysis of the correlation between the tree-ring width of Pinus tabulaeformis and the climate factors in the western Hedong sandy land of Ningxia, a conversion equation between the annual precipitation and the tree-ring width since 1899 was reconstructed. The results of cross verification indicated that the conversion equation is stable and the reconstructed results are reliable. The result of reconstructed annual precipitation showed the remarkable fluctuation of precipitation and dry-to-wet variation before the 1940s. The smaller fluctuation and high frequent changes of precipitation occurred during the period of 1940s-1980s and after the 1980s the change trend of the precipitation became high periodic extent and low frequent. The study found that there were some coincidences with the climate change in Changling Mountains, Helan Mountains and the east of Qilian Mountains. The relatively dry periods in the beginning of 20th century, 1920s to 1930s, the end of the 20th century and 2004 to 2006 in the western Hedong sandy land of Ningxia accelerated the desertification, while the relatively humid period during the periods of the 1910s-1920s, 1930s-1940s and 1990s is favorable to prevent and control the desertification, and to weaken the climate warming and drying. The periods of annual precipitation variation in the western Hedong sandy land of Ningxia since 1899 are approximately 2-4 years, 5-7 years and 10 years.展开更多
Tree-ring standardized chronologies are developed by 78 cores collected from the eastern and western Helan Mountain. Statistical analysis shows that both the STD and RES chronologies correlate negatively with the temp...Tree-ring standardized chronologies are developed by 78 cores collected from the eastern and western Helan Mountain. Statistical analysis shows that both the STD and RES chronologies correlate negatively with the temperature of different periods of early half year, especially with January to August mean (JA) temperature, which means that JA temperature is one of the predominant limiting factors of tree growth in the Helan Mountain. Based on this analysis, we reconstructed JA temperature, and the explained variance is 43.3% (F=21.422, p〈0.001 ). The comparatively high temperature periods in the reconstruction were: 1805-1818 1828-1857, 1899-1907, 1919-1931 and 1968-1995; and the comparatively low temperatu re periods happened in 1858-1872, 1883-1895 and 1935-1953. Ten-year moving average curve shows three slow uplifting trends: 1766-1853, 1862-1931 and 1944-1995. Each temperature increase was followed by a sudden temperature decrease about 10 years, that is to say, the JA temperature in the Helan Mountain is characterized by slow increase and sudden decrease. The 70- and 10.77-year periodicities detected in the temperature series correspond to the Gleissberg (80-year) and Schwabe (11-year) periodicities of solar activity respectively, the 2.11-2.62 years cycles are considered to be influenced by QBO (Quasi-Biennial-Oscillation) and the local environmental change.展开更多
Regional tree-ring width chronology of the Scots pine (Pinus sylvestris L.) was constructed from 8 sites in the forest-steppe belt situated in the foothills of the Selenga River basin, Russia. Moisture information con...Regional tree-ring width chronology of the Scots pine (Pinus sylvestris L.) was constructed from 8 sites in the forest-steppe belt situated in the foothills of the Selenga River basin, Russia. Moisture information contained in tree-ring width chronology was obtained through linear regression reconstruction models of annual August–July precipitation and annual water discharge of the Selenga River during the period 1767–2015. Comparison of the smoothed series allowed estimating long-term variation component of these moisture regime parameters with a high precision. At the same time, regional drought indices are less correlated with pine radial growth, because they have contribution of the other environmental variables, which are much less reflected in the tree-ring of the investigated pine forest stands. Reconstructed dynamic of the moisture regime parameters is supported by documental evident of many socially significant events in the regional history, such as crop failures caused by both droughts and floods, and catastrophic fire in the Irkutsk City in 1879. Also, dependence of the amount of precipitation in the study area on the atmospheric circulation in Central Asia is revealed to have a similar pattern with other regions, i.e., a negative relationship of precipitation with the development of large high atmospheric pressure area within its center in the Altai and Tianshan mountains.展开更多
August-June precipitation has been reconstructed back to AD 1720 for the northern Greater Higgnan Mountains, China, by use ofPinus sylvestris var. mongolica tree-ring width. The reconstruction explains the variance of...August-June precipitation has been reconstructed back to AD 1720 for the northern Greater Higgnan Mountains, China, by use ofPinus sylvestris var. mongolica tree-ring width. The reconstruction explains the variance of 39% in observed precipitation from 1973 to 2008. Some extremely dry/wet signals in historical documents and other precipitation reconstructions in previous studies are precisely captured in our reconstruction. Wet periods occurred during the periods of 1730 to 1746, 1789 to 1812, 1844 to 1903, 1920 to 1930, 1942 to 1961, and 1985 to 1998; while periods of 1747 to 1788, 1813 to 1843, 1904 to 1919, 1931 to 1941, and 1962 to 1984 were relatively dry. Power spectral and wavelet analyses demon- strated the existence of significant 24-year, 12-year, and 2-year cycles of variability.展开更多
The physiological response mechanisms of trees to climate change are complex,particularly across varying elevations and among different tree species.In this study,we collected tree ring samples from two dominant conif...The physiological response mechanisms of trees to climate change are complex,particularly across varying elevations and among different tree species.In this study,we collected tree ring samples from two dominant conifer species(Picea crassifolia and Pinus tabuliformis)at three elevations at the edge of the Tengger Desert.We used tree-ring width(TRW)and tree ring oxygen isotopes(δ18OTR)to investigate how species and elevations affect their responses to climate change.Pearson’s correlation analysis and relative importance analysis were used to study the specific response processes of the two conifers to climate.The results showed that the TRW was mainly controlled by Standardized Precipitation Evapotranspiration Index(SPEI)during the growing season,which means that drought stress had the greatest effect on it.Andδ18OTRmainly responded to summer relative humidity.Both TRW andδ18OTRof P.crassifolia showed higher sensitivity to climate change.This sensitivity is largely attributed to the rapid uptake of precipitation by its developed shallow-rooted root system,which allows it to retain the precipitation signal in both TRW andδ18OTR.However,P.crassifolia may be more susceptible to drought stress and growth decline or even death in the context of a warming region.Our results are important for understanding the impacts of climate change on forest ecosystems using multiple indicators and developing corresponding ecological conservation measures.展开更多
The northeastern permafrost region of China is one of the most vulnerable areas to climate warming in midlatitude areas.Despite this,the specific pathways of water vapor circulation and transport in this area remain p...The northeastern permafrost region of China is one of the most vulnerable areas to climate warming in midlatitude areas.Despite this,the specific pathways of water vapor circulation and transport in this area remain poorly understood.Additionally,there is ongoing debate on whether the oxygen isotope of precipitation(δ18Op)is primarily influenced by the temperature or the precipitation amount effects.Tree-ring samples were collected from various sites and tree species across the region,and 12 stable oxygen isotopes(δ18Oc)series constructed to investigate the water vapor signals embedded within.Our findings revealed consistentδ18Oc variations across different sites and species,reflecting relative humidity signals during the growing season(June to September)(r=−0.764,P<0.001,n=40).By applying an improved model to simulateδ18Op,a“temperature effect”was identified.Bothδ18Oc andδ18Op provided valuable insights into the regional water vapor circulation,withδ18Oc offering a stronger climate signal.A binary linear regression model further revealed thatδ18Op had a greater influence onδ18Oc than relative humidity.The regional climate is primarily driven by the East Asian summer monsoon and large-scale water vapor circulation associated with the El Niño-Southern Oscillation.Because of future warming and drying trends,trees in this region are expected to face increasing drought stress.展开更多
Using five well-replicated Qilian juniper(Sabina przewalskii Kom.)tree-ring width index se-ries,monthly normalized difference vegetation index(NDVI)of grassland,and climatic data from 1982 to 2001,the relationships be...Using five well-replicated Qilian juniper(Sabina przewalskii Kom.)tree-ring width index se-ries,monthly normalized difference vegetation index(NDVI)of grassland,and climatic data from 1982 to 2001,the relationships between tree-ring width index,NDVI of grassland,and climatic data were analyzed firstly.Then,the relationship between tree-ring width index and NDVI of grassland was explored.The re-sults showed that:(1)Temperature and precipitation in June influenced tree-ring width index and NDVI of grassland deeply in Delingha.(2)There were sig-nificant relationships between five tree-ring width index series(DLH1-DLH5)and monthly NDVI of grassland from June to September,with the most significant relationship being between tree-ring width index series and NDVI of grassland in August.(3)The PC1(the first principal component derived from DLH1-DLH5 series)exhibited good agreement with monthly NDVI of grassland in the grass growth sea-son(from June to September)and the averaged NDVI in the growth season,which was attributed to their common responses to water-supply limit in Delingha.This study may allow an increase in studying the past dynamics of grassland in Delingha in that the variation of grassland NDVI during the last millennium has been reconstructed from PC1.展开更多
Tree rings provide long-term records of tree growth and climate changes,which makes them ideal benchmarks for forest modeling.Tree-ring information has greatly improved the reliability of 3-PG,which is one of the most...Tree rings provide long-term records of tree growth and climate changes,which makes them ideal benchmarks for forest modeling.Tree-ring information has greatly improved the reliability of 3-PG,which is one of the most commonly used process-based forest growth models.Here,we strengthen 3-PG's ability to simulate tree-ring width and stable carbon isotopes(δ13C)by enhancing its descriptions of tree physiology.The major upgrade was adding a carbon storage pool for tree-ring formation using stored carbohydrates.We also incorporated previous modifications(replacing the age modifier with a height modifier)of 3-PG and tested their efficacy in improving tree-ring simulations.We ran the model based on two grand fir(Abies grandis)stands.The updated model greatly improved the simulations for both tree-ring widths andδ13C.The results represent one of the best tree-ringδ13C simulations,which accurately captured the amplitude in annual variations ofδ13C.The correlations(R2)between simulations and observations reached 0.50 and 0.73 at two stands,respectively.The new model also greatly improved the simulations of raw tree-ring widths and detrended ring-width index(RWI).Because of better descriptions of tree physiology and more accurate simulations of tree rings than the previous model version,the updated 3-PG should provide more reliable simulations than previous 3-PG versions when tree-ring information is used as a benchmark in future studies.展开更多
Leaf morphology is an important agronomic trait that affects photosynthetic efficiency and plant architecture.Some KNOXI(ClassⅠKNOTTED1-LIKE HOMEOBOX)or CIN-TCP(CINCINNATA-LIKE TEOSINTE BRANCHED1,CYCLOIDEA,and PROLIF...Leaf morphology is an important agronomic trait that affects photosynthetic efficiency and plant architecture.Some KNOXI(ClassⅠKNOTTED1-LIKE HOMEOBOX)or CIN-TCP(CINCINNATA-LIKE TEOSINTE BRANCHED1,CYCLOIDEA,and PROLIFERATING CELL FACTORS)transcription factors control leaf development by influencing GA(gibberellin)content.However,the knowledge about their interaction in regulating leaf morphogenesis is still scarce,especially in woody fruit plants such as citrus.In this study,we found that the expression of CsTCP13(a citrus CIN-TCP gene)dramatically decreased with a decreasing leaf length-width ratio in citrus.Transiently silencing CsTCP13 in citrus produced wider leaves and significantly decreased Cs GA20ox1(a key citrus GA20-oxidase gene for GA biosynthesis)expression and GAs(GA3,GA4,and GA7)contents.Conversely,stable overexpression of CsTCP13 in tobacco generated narrower leaves and significantly increased GA20ox1 expression and GA1content;it also significantly shortened the distance between veins and reduced the number of epidermal cells per unit area of leaf.Moreover,transactivation assays showed that CsTCP13 had transcriptional activation,and yeast two-hybrid,split-luciferase complementation,and bimolecular fluorescence complementation assays confirmed that CsTCP13 interacted with CsKNAT1(a citrus KNOXI protein).Furthermore,yeast one-hybrid and dual-luciferase assays validated that CsTCP13 promoted while CsKNAT1 and its interacting protein CsKNAT6 inhibited Cs GA20ox1 expression by binding to its promoter.Interestingly,CsKNAT1 or the CsKNAT1-CsKNAT6 complex interacted with CsTCP13 to attenuate its promotion effect on Cs GA20ox1 expression.Taken together,our findings revealed a novel regulatory mechanism that CsTCP13 regulates citrus leaf width through directly influencing Cs GA20ox1 expression and then GA content,which can be negatively affected by the interaction with CsKNAT1 or the CsKNAT1-CsKNAT6 complex.展开更多
Investigating the detonation reaction zone structures of high explosives is significant for understanding detonation reaction mechanism.This study employed an integrated approach combining machine learning prediction,...Investigating the detonation reaction zone structures of high explosives is significant for understanding detonation reaction mechanism.This study employed an integrated approach combining machine learning prediction,theoretical calculation,and experimental characterization to determine the detonation reaction zone width of CL-20-based aluminized explosive.In this study,the detonation reaction zone refers to the reaction zone between the von Neumann(VN)peak and sonic point,which usually means the so-called detonation driving zone(DDZ).For the machine learning prediction,an ensemble model integrating Random Forest and Support Vector Regression was developed to predict the reaction zone width using a dataset of 19 publicly available samples.For the theoretical calculation,the Wood-Kirkwood(W-K)detonation theory model was utilized to implement numerical calculation of the reaction zone structures,incorporating chemical reaction kinetics to describe the detonation reaction progress.In experimental characterization,the Photon Doppler Velocimetry(PDV)was applied with LiF as the optical window to measure the particle velocity profile of detonation products and derive the reaction zone width.The results indicate that the reaction zone width values are 0.25 mm,0.28 mm,and 0.26 mm obtained from machine learning prediction,theoretical calculation,and experimental characterization,respectively.The corresponding velocities at the Chapman-Jouguet(CJ)point are 1,938 m/s,2,047 m/s,and 1,982 m/s,respectively.The maximum relative deviation in reaction zone width among three methods is approximately 7.7%,while that for CJ particle velocity is approximately 3.3%.These results from all three methods agree well within engineering error.This validates the effectiveness of integrating machine learning prediction,theoretical calculation and advanced experimental techniques for studying the detonation reaction zone structures of high explosives.This research provides insights into the detonation reaction mechanism and reaction zone characteristics of CL-20-based aluminized explosive.展开更多
Developing predictive models for rock avalanche runout is crucial for hazard risk mitigation and management,while also deepening the understanding of rock avalanche dynamics.In this study,a database of 63 representati...Developing predictive models for rock avalanche runout is crucial for hazard risk mitigation and management,while also deepening the understanding of rock avalanche dynamics.In this study,a database of 63 representative rock avalanches was compiled,and the geometric characteristics of these events were analyzed.Traditional regression methods were compared with neural network regression(NNR)approaches to find the optimal model.Model parameters,loss functions,and evaluation metrics were examined to determine optimal configurations.Based on correlation analyses and model performance,this study recommends the use of source area width as an alternative to failure volume in runout prediction models,effectively addressing the common challenge of estimating avalanche volume.Ultimately,an NNR-based model,utilizing mean squared logarithmic error as the loss function and incorporating source area width and fall height as input parameters,was identified as the optimal approach.This model achieved prediction errors within a−50% to 50% range with 95.2% probability,yielding a mean absolute percentage error of 23.22% and an R2 of 0.85.These findings enhance rock avalanche prediction methodologies,providing more accurate tools for assessing the potential impact zones of destructive geological events.展开更多
Reconstructing the hydrological change based on dendrohydrological data has important implications for understanding the dynamic distribution and evolution pattern of a given river. The widespread, long-living conifer...Reconstructing the hydrological change based on dendrohydrological data has important implications for understanding the dynamic distribution and evolution pattern of a given river. The widespread, long-living coniferous forests on the Altay Mountains provide a good example for carrying out the dendrohydrological studies. In this study, a regional composite tree-ring width chronology developed by Lariat sibirica Ledeb. and Picea obovata Ledeb. was used to reconstruct a 301-year annual (from preceding July to succeeding June) streamflow for the Haba River, which originates in the southern Altay Mountains, Xinjiang, China. Results indicated that the reconstructed streamflow series and the observations were fitting well, and explained 47.5% of the variation in the observed streamflow of 1957-2008. Moreover, floods and droughts in 1949-2000 were precisely captured by the streamflow reconstruction. Based on the frequencies of the wettest/driest years and decades, we identified the 19th century as the century with the largest occurrence of hydrological fluctuations for the last 300 years. After applying a 21-year moving average, we found five wet (1724-1758, 1780-1810, 1822-1853, 1931-1967, and 1986-2004) and four dry (1759-1779, 1811-1821, 1854-1930, and 1968-1985) periods in the streamflow reconstruction. Furthermore, four periods (1770-1796, 1816-1836, 1884-1949, and 1973-1997) identified by the streamflow series had an obvious increasing trend. The increasing trend of streamflow since the 1970s was the biggest in the last 300 years and coincided with the recent warming-wetting trend in northwestern China. A significant correlation between streamflow and precipitation in the Altay Mountains indicated that the streamflow reconstruction contained not only local, but also broad-scale, hydro-climatic signals. The 24-year, 12-year, and 2.2-4.5-year cycles of the reconstruction revealed that the streamflow variability of the Haba River may be influenced by solar activity and the atmosphere-ocean system.展开更多
Microwave ablation(MWA)is a minimally invasive technique for treating hepatic tumors,necessitating precise monitoring to ensure treatment efficacy and minimize damage to surrounding tissues.This study explores the pot...Microwave ablation(MWA)is a minimally invasive technique for treating hepatic tumors,necessitating precise monitoring to ensure treatment efficacy and minimize damage to surrounding tissues.This study explores the potential of photoacoustic imaging(PAI)in monitoring MWA by examining ex vivo porcine liver tissues.In this study,a comprehensive analysis of photoacoustic signals was performed to compare the main lobe width(MLW)between ablated and normal regions in porcine liver tissue.Histological staining with succinate dehydrogenase(SDH)and shear wave elastography(SWE)were employed to validate the changes in tissue elasticity after ablation.The analysis demonstrated a notable reduction in the MLW of the average A-lines in ablated tissues compared to nonablated regions(p<0.01).This reduction,attributed to increased tissue density and enhanced elasticity,indicates accelerated sound propagation in thermally ablated areas,which then serves as a critical parameter for mapping tissue characteristics.The reconstruction of the MLW distribution successfully delineated the ablated regions,and was consistent with the results of SDH staining and SWE.In addition,MLW-based imaging exhibited higher spatial resolution compared to SWE.Incorporating MLW analysis into PAI may be a promising strategy to improve the accuracy and effectiveness of MWA monitoring in clinical settings.展开更多
Droughts are the most frequent natural disaster in regions at the margins of the East Asian summer monsoon(EASM),which pose threats to agriculture,the economy,and human lives.However,the limitations of only approximat...Droughts are the most frequent natural disaster in regions at the margins of the East Asian summer monsoon(EASM),which pose threats to agriculture,the economy,and human lives.However,the limitations of only approximately 60 years of meteorological observations hamper our understanding of the characteristics and mechanisms of local hydroclimate.Trees growing in the marginal region of the EASM are usually sensitive to moisture variations and have played important roles in past hydroclimatic reconstructions.Here,a 303-year tree-ring-width chronology of Pinus tabulaeformis from Mt.Lama,which is located in the junction of the Liaoning Province and Inner Mongolia,China,was used to reconstruct the May-August Palmer drought severity index(PDSI)in the marginal region of the EASM.The transfer function explains 48.0%(or 47.2%after adjusting for the loss of the degrees of freedom)of the variance over the calibration period from 1946 to 2012.A spatial correlation analysis demonstrates that our PDSI reconstruction can represent the drought variability on the northernmost margin of the EASM.The winter Asian polar vortex area index showed a delayed impact on the summer EASM precipitation in the following year.展开更多
This study investigates the width of the secondary eyewall(SE)immediately following its formation in tropical cyclones with surface environmental winds aligned and counter-aligned with environmental vertical wind shea...This study investigates the width of the secondary eyewall(SE)immediately following its formation in tropical cyclones with surface environmental winds aligned and counter-aligned with environmental vertical wind shear(VWS),using idealized numerical experiments.Results reveal that the SE develops greater radial extent when surface winds align with VWS compared to counter-aligned conditions.In alignment configurations,shear-enhanced surface winds on the right flank amplify surface enthalpy fluxes,thereby elevating boundary-layer entropy within the downshear outer-core region.Subsequently,more vigorous outer rainbands develop,inducing marked acceleration of tangential winds in the outer core preceding SE formation.The resultant radial expansion of supergradient winds near the boundary-layer top triggers widespread convective activity immediately beyond the inner core.Progressive axisymmetrization of this convective forcing ultimately generates an expansive SE structure.展开更多
The study conducted by Martli et al,on the preoperative risk stratification of malignant potential in pancreatic cystic neoplasms(PCNs),identifies age and red cell distribution width(RDW)as independent predictors.This...The study conducted by Martli et al,on the preoperative risk stratification of malignant potential in pancreatic cystic neoplasms(PCNs),identifies age and red cell distribution width(RDW)as independent predictors.This study offers a simple and cost-effective clinical tool for preoperative assessments.The significance lies in its integration of routine laboratory parameters with clinical features,effectively addressing the limitations associated with the accessibility and operator dependency of imaging and invasive diagnostic methods.However,factors such as the retrospective design,single-center setting,small sample size,and selection bias because of the inclusion of only surgical cases limit the generalizability of the findings.Future studies should emphasize multi-center prospective validation to further clarify the biological role of RDW in the malignant transformation of PCNs and to explore integrated models that combine RDW with imaging characteristics and molecular biomarkers,ultimately enhancing precision in individualized clinical decision-making.展开更多
BACKGROUND Red cell distribution width(RDW)measures the red blood cell size variation.Elevated RDW has been associated with various adverse health outcomes,including cardiovascular diseases.AIM To analyze current evid...BACKGROUND Red cell distribution width(RDW)measures the red blood cell size variation.Elevated RDW has been associated with various adverse health outcomes,including cardiovascular diseases.AIM To analyze current evidence on the prognostic significance of high RDW in patients with heart failure(HF).METHODS A comprehensive literature search was conducted across multiple databases,including PubMed,EMBASE,and Google Scholar,up to May 2024.Studies were included if they investigated the relationship between RDW levels and outcomes in HF patients.Compared to those in the lowest quartile.The primary outcome was all-cause mortality.Compared to those in the lowest quartile.Heterogeneity was assessed using the I2 statistic,we assessed the impact of individual studies on the overall estimate using a leave-one-out sensitivity analysis and publication bias was evaluated through a contour-enhanced funnel plot and Luis Furuya-Kanamori(LFK)index.RESULTS Seven studies,including a total of 11460 HF patients,were analyzed.The participants'mean age varied between 60 years and 80 years,with 6562(57.26%)in the lower quartile.Patients in the highest quartile of RDW(>15.21%)had a significantly increased risk of all-cause mortality,with an odds ratio of 1.84(95%CI:1.31-2.57,P<0.001),compared to those in the lowest quartile(RDW:14.1%-15.20%).There was significant variability in the included studies'results(I2=93%,P<0.01),as well as potential publication bias suggested by the high LFK index(8.47).Sensitivity analysis reinforced the robustness of these findings,showing that the results were not unduly influenced by any single study.CONCLUSION This meta-analysis confirms that high RDW is a robust predictor of adverse outcomes in patients with HF,highlighting its potential utility as a simple,cost-effective biomarker for risk stratification.Future research should focus on elucidating the mechanisms underlying this association and exploring the potential benefits of RDWguided therapeutic strategies in HF management.展开更多
The purpose of this study was to clarify the effects of different sidewalk widths on the driving characteristics of electric wheelchairs and on the user’s psychology and safety.Eighteen participants drove electric wh...The purpose of this study was to clarify the effects of different sidewalk widths on the driving characteristics of electric wheelchairs and on the user’s psychology and safety.Eighteen participants drove electric wheelchairs on both wide and narrow sidewalks.Data collection included:(1)the number of cyclists and pedestrians passing by,(2)driving speed,(3)an 11-item questionnaire,and(4)a post-test ride interview.The results showed that the number of cyclists and pedestrians they passed and their driving speed were significantly higher on wide sidewalks.On the other hand,on narrow sidewalks,negative evaluations were frequently given,including the difficulty of avoiding steps,slopes,and utility poles,anxiety and psychological tension associated with pedestrian consideration,and difficulty in operation.These results indicate that sidewalk width is not just a physical space,but also an important environmental factor that strongly influences users’anxiety,operational burden,and distance adjustment from pedestrians.Creating a safe and comfortable mobility environment requires both improvements to sidewalk infrastructure and innovations in mobility devices.展开更多
Tree-ring width chronologies of Larix chinensis were developed from the northern and southern slopes of the Qinling Mountains in Shaanxi Province,and climatic factors affecting the tree-ring widths of L.chinensis were...Tree-ring width chronologies of Larix chinensis were developed from the northern and southern slopes of the Qinling Mountains in Shaanxi Province,and climatic factors affecting the tree-ring widths of L.chinensis were examined.Correlation analysis showed that similar correlations between tree-ring width chronologies and climatic factors demonstrated that radial growth responded to climate change on both slopes.The radial growth of L.chinensis was mainly limited by temperature,especially the growing season.In contrast,both chronologies were negatively correlated with precipitation in May of the previous year and April of the current year.Spatial climate-correlation analyses with gridded land-surface climate data revealed that our tree-ring width chronologies contained a strong regional temperature signal over much of northcentral and eastern China.Spatial correlation with seasurface temperature fields highlights the influence of the Pacific Ocean,Indian Ocean,and North Atlantic Ocean.Wavelet coherence analysis indicated the existence of some decadal and interannual cycles in the two tree-ring width chronologies.This may suggest the influences of El Nin˜o-Southern Oscillation and solar activity on tree growth in the Qinling Mountains.These findings will help us understand the growth response of L.chinensis to climate change in the Qinling region,and they provide critical information for future climate reconstructions based on this species in semi-humid regions.展开更多
基金supported the National Natural Science Foundation of China (42022059,41888101)the Strategic Priority Research Program of the Chinese Academy of Sciences,China (Grant No.XDB26020000)+1 种基金the Key Research Program of the Institute of Geology and Geophysics (CAS Grant IGGCAS-201905)the CAS Youth Interdisciplinary Team (JCTD-2021-05).
摘要Tree-ring width(RW),density,elemental com-position,and stable carbon and oxygen isotope(δ13C,δ18O)are widely used as proxies to assess climate change,ecology,and environmental pollution;however,a specific pretreat-ment has been needed for each proxy.Here,we developed a method by which each proxy can be measured in the same sample.First,the sample is polished for ring width meas-urement.After obtaining the ring width data,the sample is cut to form a 1-mm-thick wood plate.The sample is then mounted in a vertical sample holder,and gradually scanned by an X-ray beam.Simultaneously,the count rates of the fluorescent photons of elements(for chemical characteriza-tion)and a radiographic grayscale image(for wood density)are obtained,i.e.the density and the element content are obtained.Then,cellulose is isolated from the 1-mm wood plate by removal of lignin,and hemicellulose.After producing this cellulose plate,cellulose subsamples are separated by knife under the microscope for inter-annual and intra-annual stable carbon and oxygen isotope(δ13C,δ18O)analysis.Based on this method,RW,density,elemental composition,δ13C,and δ18O can be measured from the same sample,which reduces sample amount and treatment time,and is helpful for multi-proxy comparison and combination research.
基金supported by the National Natural Science Foundation of China (40801004, 40671184)the Research Fund for the Doctoral Program of Higher Education (20070027019)
摘要Based on the analysis of the correlation between the tree-ring width of Pinus tabulaeformis and the climate factors in the western Hedong sandy land of Ningxia, a conversion equation between the annual precipitation and the tree-ring width since 1899 was reconstructed. The results of cross verification indicated that the conversion equation is stable and the reconstructed results are reliable. The result of reconstructed annual precipitation showed the remarkable fluctuation of precipitation and dry-to-wet variation before the 1940s. The smaller fluctuation and high frequent changes of precipitation occurred during the period of 1940s-1980s and after the 1980s the change trend of the precipitation became high periodic extent and low frequent. The study found that there were some coincidences with the climate change in Changling Mountains, Helan Mountains and the east of Qilian Mountains. The relatively dry periods in the beginning of 20th century, 1920s to 1930s, the end of the 20th century and 2004 to 2006 in the western Hedong sandy land of Ningxia accelerated the desertification, while the relatively humid period during the periods of the 1910s-1920s, 1930s-1940s and 1990s is favorable to prevent and control the desertification, and to weaken the climate warming and drying. The periods of annual precipitation variation in the western Hedong sandy land of Ningxia since 1899 are approximately 2-4 years, 5-7 years and 10 years.
基金National Natural Science Foundation of China, No.40525004 No.40599420+2 种基金 No.90211081 No.40531003 No.40121303
摘要Tree-ring standardized chronologies are developed by 78 cores collected from the eastern and western Helan Mountain. Statistical analysis shows that both the STD and RES chronologies correlate negatively with the temperature of different periods of early half year, especially with January to August mean (JA) temperature, which means that JA temperature is one of the predominant limiting factors of tree growth in the Helan Mountain. Based on this analysis, we reconstructed JA temperature, and the explained variance is 43.3% (F=21.422, p〈0.001 ). The comparatively high temperature periods in the reconstruction were: 1805-1818 1828-1857, 1899-1907, 1919-1931 and 1968-1995; and the comparatively low temperatu re periods happened in 1858-1872, 1883-1895 and 1935-1953. Ten-year moving average curve shows three slow uplifting trends: 1766-1853, 1862-1931 and 1944-1995. Each temperature increase was followed by a sudden temperature decrease about 10 years, that is to say, the JA temperature in the Helan Mountain is characterized by slow increase and sudden decrease. The 70- and 10.77-year periodicities detected in the temperature series correspond to the Gleissberg (80-year) and Schwabe (11-year) periodicities of solar activity respectively, the 2.11-2.62 years cycles are considered to be influenced by QBO (Quasi-Biennial-Oscillation) and the local environmental change.
基金funded by the Russian Foundation for Basic Research (17-04-00315)the Russian Science Foundation (14-14-00219)
摘要Regional tree-ring width chronology of the Scots pine (Pinus sylvestris L.) was constructed from 8 sites in the forest-steppe belt situated in the foothills of the Selenga River basin, Russia. Moisture information contained in tree-ring width chronology was obtained through linear regression reconstruction models of annual August–July precipitation and annual water discharge of the Selenga River during the period 1767–2015. Comparison of the smoothed series allowed estimating long-term variation component of these moisture regime parameters with a high precision. At the same time, regional drought indices are less correlated with pine radial growth, because they have contribution of the other environmental variables, which are much less reflected in the tree-ring of the investigated pine forest stands. Reconstructed dynamic of the moisture regime parameters is supported by documental evident of many socially significant events in the regional history, such as crop failures caused by both droughts and floods, and catastrophic fire in the Irkutsk City in 1879. Also, dependence of the amount of precipitation in the study area on the atmospheric circulation in Central Asia is revealed to have a similar pattern with other regions, i.e., a negative relationship of precipitation with the development of large high atmospheric pressure area within its center in the Altai and Tianshan mountains.
基金supported by the Climate Change Special Project of China Meteorological Administration (CCSF201438)the Meteorology Public Welfare Industry Research Special Project (GYHY201106013-3 and GYHY200806011)the Basic Research Operating Expenses of the Central-level Public Welfare Research Institutes (IDM201204)
摘要August-June precipitation has been reconstructed back to AD 1720 for the northern Greater Higgnan Mountains, China, by use ofPinus sylvestris var. mongolica tree-ring width. The reconstruction explains the variance of 39% in observed precipitation from 1973 to 2008. Some extremely dry/wet signals in historical documents and other precipitation reconstructions in previous studies are precisely captured in our reconstruction. Wet periods occurred during the periods of 1730 to 1746, 1789 to 1812, 1844 to 1903, 1920 to 1930, 1942 to 1961, and 1985 to 1998; while periods of 1747 to 1788, 1813 to 1843, 1904 to 1919, 1931 to 1941, and 1962 to 1984 were relatively dry. Power spectral and wavelet analyses demon- strated the existence of significant 24-year, 12-year, and 2-year cycles of variability.
基金supported by National Natural Science Foundation of China(no.42371038)Basic Research Innovation Group Project of Gansu Province(no.22JR5RA129)the 2022 Major Scientific Research Project Cultivation Plan of Northwest Normal University(NWNU-LKZD2022-04).
摘要The physiological response mechanisms of trees to climate change are complex,particularly across varying elevations and among different tree species.In this study,we collected tree ring samples from two dominant conifer species(Picea crassifolia and Pinus tabuliformis)at three elevations at the edge of the Tengger Desert.We used tree-ring width(TRW)and tree ring oxygen isotopes(δ18OTR)to investigate how species and elevations affect their responses to climate change.Pearson’s correlation analysis and relative importance analysis were used to study the specific response processes of the two conifers to climate.The results showed that the TRW was mainly controlled by Standardized Precipitation Evapotranspiration Index(SPEI)during the growing season,which means that drought stress had the greatest effect on it.Andδ18OTRmainly responded to summer relative humidity.Both TRW andδ18OTRof P.crassifolia showed higher sensitivity to climate change.This sensitivity is largely attributed to the rapid uptake of precipitation by its developed shallow-rooted root system,which allows it to retain the precipitation signal in both TRW andδ18OTR.However,P.crassifolia may be more susceptible to drought stress and growth decline or even death in the context of a warming region.Our results are important for understanding the impacts of climate change on forest ecosystems using multiple indicators and developing corresponding ecological conservation measures.
基金supported by the National Natural Science Foundation of China(Grant Nos.42173080 and 42488201)the Chinese Academy of Sciences(Grant No.XDB40010300)the Young Talent Support Plan of Xi’an Jiaotong University.
摘要The northeastern permafrost region of China is one of the most vulnerable areas to climate warming in midlatitude areas.Despite this,the specific pathways of water vapor circulation and transport in this area remain poorly understood.Additionally,there is ongoing debate on whether the oxygen isotope of precipitation(δ18Op)is primarily influenced by the temperature or the precipitation amount effects.Tree-ring samples were collected from various sites and tree species across the region,and 12 stable oxygen isotopes(δ18Oc)series constructed to investigate the water vapor signals embedded within.Our findings revealed consistentδ18Oc variations across different sites and species,reflecting relative humidity signals during the growing season(June to September)(r=−0.764,P<0.001,n=40).By applying an improved model to simulateδ18Op,a“temperature effect”was identified.Bothδ18Oc andδ18Op provided valuable insights into the regional water vapor circulation,withδ18Oc offering a stronger climate signal.A binary linear regression model further revealed thatδ18Op had a greater influence onδ18Oc than relative humidity.The regional climate is primarily driven by the East Asian summer monsoon and large-scale water vapor circulation associated with the El Niño-Southern Oscillation.Because of future warming and drying trends,trees in this region are expected to face increasing drought stress.
基金This work Was supported by the Key Program of the National Natural Science Foundation of China(Grant No.40331006)the Key Project of Knowledge Innovation of the Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences(Grant No.CXI0G-E01-05-02).
摘要Using five well-replicated Qilian juniper(Sabina przewalskii Kom.)tree-ring width index se-ries,monthly normalized difference vegetation index(NDVI)of grassland,and climatic data from 1982 to 2001,the relationships between tree-ring width index,NDVI of grassland,and climatic data were analyzed firstly.Then,the relationship between tree-ring width index and NDVI of grassland was explored.The re-sults showed that:(1)Temperature and precipitation in June influenced tree-ring width index and NDVI of grassland deeply in Delingha.(2)There were sig-nificant relationships between five tree-ring width index series(DLH1-DLH5)and monthly NDVI of grassland from June to September,with the most significant relationship being between tree-ring width index series and NDVI of grassland in August.(3)The PC1(the first principal component derived from DLH1-DLH5 series)exhibited good agreement with monthly NDVI of grassland in the grass growth sea-son(from June to September)and the averaged NDVI in the growth season,which was attributed to their common responses to water-supply limit in Delingha.This study may allow an increase in studying the past dynamics of grassland in Delingha in that the variation of grassland NDVI during the last millennium has been reconstructed from PC1.
基金supported by the National Natural Science Foundation of China(Nos.42271048,42430503,and 31971492).
摘要Tree rings provide long-term records of tree growth and climate changes,which makes them ideal benchmarks for forest modeling.Tree-ring information has greatly improved the reliability of 3-PG,which is one of the most commonly used process-based forest growth models.Here,we strengthen 3-PG's ability to simulate tree-ring width and stable carbon isotopes(δ13C)by enhancing its descriptions of tree physiology.The major upgrade was adding a carbon storage pool for tree-ring formation using stored carbohydrates.We also incorporated previous modifications(replacing the age modifier with a height modifier)of 3-PG and tested their efficacy in improving tree-ring simulations.We ran the model based on two grand fir(Abies grandis)stands.The updated model greatly improved the simulations for both tree-ring widths andδ13C.The results represent one of the best tree-ringδ13C simulations,which accurately captured the amplitude in annual variations ofδ13C.The correlations(R2)between simulations and observations reached 0.50 and 0.73 at two stands,respectively.The new model also greatly improved the simulations of raw tree-ring widths and detrended ring-width index(RWI).Because of better descriptions of tree physiology and more accurate simulations of tree rings than the previous model version,the updated 3-PG should provide more reliable simulations than previous 3-PG versions when tree-ring information is used as a benchmark in future studies.
基金supported by the National Natural Science Foundation of China(Grant No.32172509)the earmarked fund for CARS-26。
摘要Leaf morphology is an important agronomic trait that affects photosynthetic efficiency and plant architecture.Some KNOXI(ClassⅠKNOTTED1-LIKE HOMEOBOX)or CIN-TCP(CINCINNATA-LIKE TEOSINTE BRANCHED1,CYCLOIDEA,and PROLIFERATING CELL FACTORS)transcription factors control leaf development by influencing GA(gibberellin)content.However,the knowledge about their interaction in regulating leaf morphogenesis is still scarce,especially in woody fruit plants such as citrus.In this study,we found that the expression of CsTCP13(a citrus CIN-TCP gene)dramatically decreased with a decreasing leaf length-width ratio in citrus.Transiently silencing CsTCP13 in citrus produced wider leaves and significantly decreased Cs GA20ox1(a key citrus GA20-oxidase gene for GA biosynthesis)expression and GAs(GA3,GA4,and GA7)contents.Conversely,stable overexpression of CsTCP13 in tobacco generated narrower leaves and significantly increased GA20ox1 expression and GA1content;it also significantly shortened the distance between veins and reduced the number of epidermal cells per unit area of leaf.Moreover,transactivation assays showed that CsTCP13 had transcriptional activation,and yeast two-hybrid,split-luciferase complementation,and bimolecular fluorescence complementation assays confirmed that CsTCP13 interacted with CsKNAT1(a citrus KNOXI protein).Furthermore,yeast one-hybrid and dual-luciferase assays validated that CsTCP13 promoted while CsKNAT1 and its interacting protein CsKNAT6 inhibited Cs GA20ox1 expression by binding to its promoter.Interestingly,CsKNAT1 or the CsKNAT1-CsKNAT6 complex interacted with CsTCP13 to attenuate its promotion effect on Cs GA20ox1 expression.Taken together,our findings revealed a novel regulatory mechanism that CsTCP13 regulates citrus leaf width through directly influencing Cs GA20ox1 expression and then GA content,which can be negatively affected by the interaction with CsKNAT1 or the CsKNAT1-CsKNAT6 complex.
摘要Investigating the detonation reaction zone structures of high explosives is significant for understanding detonation reaction mechanism.This study employed an integrated approach combining machine learning prediction,theoretical calculation,and experimental characterization to determine the detonation reaction zone width of CL-20-based aluminized explosive.In this study,the detonation reaction zone refers to the reaction zone between the von Neumann(VN)peak and sonic point,which usually means the so-called detonation driving zone(DDZ).For the machine learning prediction,an ensemble model integrating Random Forest and Support Vector Regression was developed to predict the reaction zone width using a dataset of 19 publicly available samples.For the theoretical calculation,the Wood-Kirkwood(W-K)detonation theory model was utilized to implement numerical calculation of the reaction zone structures,incorporating chemical reaction kinetics to describe the detonation reaction progress.In experimental characterization,the Photon Doppler Velocimetry(PDV)was applied with LiF as the optical window to measure the particle velocity profile of detonation products and derive the reaction zone width.The results indicate that the reaction zone width values are 0.25 mm,0.28 mm,and 0.26 mm obtained from machine learning prediction,theoretical calculation,and experimental characterization,respectively.The corresponding velocities at the Chapman-Jouguet(CJ)point are 1,938 m/s,2,047 m/s,and 1,982 m/s,respectively.The maximum relative deviation in reaction zone width among three methods is approximately 7.7%,while that for CJ particle velocity is approximately 3.3%.These results from all three methods agree well within engineering error.This validates the effectiveness of integrating machine learning prediction,theoretical calculation and advanced experimental techniques for studying the detonation reaction zone structures of high explosives.This research provides insights into the detonation reaction mechanism and reaction zone characteristics of CL-20-based aluminized explosive.
基金funded by the National Key R&D Program of China(2023YFC3007201)National Natural Science Foundation of China(42377167)。
摘要Developing predictive models for rock avalanche runout is crucial for hazard risk mitigation and management,while also deepening the understanding of rock avalanche dynamics.In this study,a database of 63 representative rock avalanches was compiled,and the geometric characteristics of these events were analyzed.Traditional regression methods were compared with neural network regression(NNR)approaches to find the optimal model.Model parameters,loss functions,and evaluation metrics were examined to determine optimal configurations.Based on correlation analyses and model performance,this study recommends the use of source area width as an alternative to failure volume in runout prediction models,effectively addressing the common challenge of estimating avalanche volume.Ultimately,an NNR-based model,utilizing mean squared logarithmic error as the loss function and incorporating source area width and fall height as input parameters,was identified as the optimal approach.This model achieved prediction errors within a−50% to 50% range with 95.2% probability,yielding a mean absolute percentage error of 23.22% and an R2 of 0.85.These findings enhance rock avalanche prediction methodologies,providing more accurate tools for assessing the potential impact zones of destructive geological events.
基金supported by the National Natural Science Foundation of China (41275120, 41605047)the Shanghai Cooperation Organization Science and Technology Partnership (2017E01032)+1 种基金the Special Foundation for Asian Regional Cooperation (Climate Reconstruction of Tian Shan in China, Kyrgyzstan and Tajikistan)the Autonomous Region Youth Science and Technology Innovation Talents Training Project (qn2015bs025)
摘要Reconstructing the hydrological change based on dendrohydrological data has important implications for understanding the dynamic distribution and evolution pattern of a given river. The widespread, long-living coniferous forests on the Altay Mountains provide a good example for carrying out the dendrohydrological studies. In this study, a regional composite tree-ring width chronology developed by Lariat sibirica Ledeb. and Picea obovata Ledeb. was used to reconstruct a 301-year annual (from preceding July to succeeding June) streamflow for the Haba River, which originates in the southern Altay Mountains, Xinjiang, China. Results indicated that the reconstructed streamflow series and the observations were fitting well, and explained 47.5% of the variation in the observed streamflow of 1957-2008. Moreover, floods and droughts in 1949-2000 were precisely captured by the streamflow reconstruction. Based on the frequencies of the wettest/driest years and decades, we identified the 19th century as the century with the largest occurrence of hydrological fluctuations for the last 300 years. After applying a 21-year moving average, we found five wet (1724-1758, 1780-1810, 1822-1853, 1931-1967, and 1986-2004) and four dry (1759-1779, 1811-1821, 1854-1930, and 1968-1985) periods in the streamflow reconstruction. Furthermore, four periods (1770-1796, 1816-1836, 1884-1949, and 1973-1997) identified by the streamflow series had an obvious increasing trend. The increasing trend of streamflow since the 1970s was the biggest in the last 300 years and coincided with the recent warming-wetting trend in northwestern China. A significant correlation between streamflow and precipitation in the Altay Mountains indicated that the streamflow reconstruction contained not only local, but also broad-scale, hydro-climatic signals. The 24-year, 12-year, and 2.2-4.5-year cycles of the reconstruction revealed that the streamflow variability of the Haba River may be influenced by solar activity and the atmosphere-ocean system.
基金supported by the National Natural Science Foundation of China(82427808,61875085)the Jiangsu Provincial University Natural Science Foundation(25KJB413004)+1 种基金the Nanjing Health Science and Technology Development Foundation(ZKX24043)the Fundamental Research Funds for the Central Universities(NJ2024029).
摘要Microwave ablation(MWA)is a minimally invasive technique for treating hepatic tumors,necessitating precise monitoring to ensure treatment efficacy and minimize damage to surrounding tissues.This study explores the potential of photoacoustic imaging(PAI)in monitoring MWA by examining ex vivo porcine liver tissues.In this study,a comprehensive analysis of photoacoustic signals was performed to compare the main lobe width(MLW)between ablated and normal regions in porcine liver tissue.Histological staining with succinate dehydrogenase(SDH)and shear wave elastography(SWE)were employed to validate the changes in tissue elasticity after ablation.The analysis demonstrated a notable reduction in the MLW of the average A-lines in ablated tissues compared to nonablated regions(p<0.01).This reduction,attributed to increased tissue density and enhanced elasticity,indicates accelerated sound propagation in thermally ablated areas,which then serves as a critical parameter for mapping tissue characteristics.The reconstruction of the MLW distribution successfully delineated the ablated regions,and was consistent with the results of SDH staining and SWE.In addition,MLW-based imaging exhibited higher spatial resolution compared to SWE.Incorporating MLW analysis into PAI may be a promising strategy to improve the accuracy and effectiveness of MWA monitoring in clinical settings.
基金The Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDB40000000National Natural Science Foundation of China,No.41630531State Key Laboratory of Loess and Quaternary Geology,Institute of Earth Environment,CAS,No.SKLLQG2041。
摘要Droughts are the most frequent natural disaster in regions at the margins of the East Asian summer monsoon(EASM),which pose threats to agriculture,the economy,and human lives.However,the limitations of only approximately 60 years of meteorological observations hamper our understanding of the characteristics and mechanisms of local hydroclimate.Trees growing in the marginal region of the EASM are usually sensitive to moisture variations and have played important roles in past hydroclimatic reconstructions.Here,a 303-year tree-ring-width chronology of Pinus tabulaeformis from Mt.Lama,which is located in the junction of the Liaoning Province and Inner Mongolia,China,was used to reconstruct the May-August Palmer drought severity index(PDSI)in the marginal region of the EASM.The transfer function explains 48.0%(or 47.2%after adjusting for the loss of the degrees of freedom)of the variance over the calibration period from 1946 to 2012.A spatial correlation analysis demonstrates that our PDSI reconstruction can represent the drought variability on the northernmost margin of the EASM.The winter Asian polar vortex area index showed a delayed impact on the summer EASM precipitation in the following year.
基金jointly supported by the National Natural Science Foundation of China[grant numbers U2342202,42175005,and 42175016]the Qing Lan Project[grant number R2023Q06]。
摘要This study investigates the width of the secondary eyewall(SE)immediately following its formation in tropical cyclones with surface environmental winds aligned and counter-aligned with environmental vertical wind shear(VWS),using idealized numerical experiments.Results reveal that the SE develops greater radial extent when surface winds align with VWS compared to counter-aligned conditions.In alignment configurations,shear-enhanced surface winds on the right flank amplify surface enthalpy fluxes,thereby elevating boundary-layer entropy within the downshear outer-core region.Subsequently,more vigorous outer rainbands develop,inducing marked acceleration of tangential winds in the outer core preceding SE formation.The resultant radial expansion of supergradient winds near the boundary-layer top triggers widespread convective activity immediately beyond the inner core.Progressive axisymmetrization of this convective forcing ultimately generates an expansive SE structure.
摘要The study conducted by Martli et al,on the preoperative risk stratification of malignant potential in pancreatic cystic neoplasms(PCNs),identifies age and red cell distribution width(RDW)as independent predictors.This study offers a simple and cost-effective clinical tool for preoperative assessments.The significance lies in its integration of routine laboratory parameters with clinical features,effectively addressing the limitations associated with the accessibility and operator dependency of imaging and invasive diagnostic methods.However,factors such as the retrospective design,single-center setting,small sample size,and selection bias because of the inclusion of only surgical cases limit the generalizability of the findings.Future studies should emphasize multi-center prospective validation to further clarify the biological role of RDW in the malignant transformation of PCNs and to explore integrated models that combine RDW with imaging characteristics and molecular biomarkers,ultimately enhancing precision in individualized clinical decision-making.
摘要BACKGROUND Red cell distribution width(RDW)measures the red blood cell size variation.Elevated RDW has been associated with various adverse health outcomes,including cardiovascular diseases.AIM To analyze current evidence on the prognostic significance of high RDW in patients with heart failure(HF).METHODS A comprehensive literature search was conducted across multiple databases,including PubMed,EMBASE,and Google Scholar,up to May 2024.Studies were included if they investigated the relationship between RDW levels and outcomes in HF patients.Compared to those in the lowest quartile.The primary outcome was all-cause mortality.Compared to those in the lowest quartile.Heterogeneity was assessed using the I2 statistic,we assessed the impact of individual studies on the overall estimate using a leave-one-out sensitivity analysis and publication bias was evaluated through a contour-enhanced funnel plot and Luis Furuya-Kanamori(LFK)index.RESULTS Seven studies,including a total of 11460 HF patients,were analyzed.The participants'mean age varied between 60 years and 80 years,with 6562(57.26%)in the lower quartile.Patients in the highest quartile of RDW(>15.21%)had a significantly increased risk of all-cause mortality,with an odds ratio of 1.84(95%CI:1.31-2.57,P<0.001),compared to those in the lowest quartile(RDW:14.1%-15.20%).There was significant variability in the included studies'results(I2=93%,P<0.01),as well as potential publication bias suggested by the high LFK index(8.47).Sensitivity analysis reinforced the robustness of these findings,showing that the results were not unduly influenced by any single study.CONCLUSION This meta-analysis confirms that high RDW is a robust predictor of adverse outcomes in patients with HF,highlighting its potential utility as a simple,cost-effective biomarker for risk stratification.Future research should focus on elucidating the mechanisms underlying this association and exploring the potential benefits of RDWguided therapeutic strategies in HF management.
基金supported by the Grant-in-Aid for Scientific Research(C)“Verification of Opportunities to Go out and Improvement of QOL by Using an Electric Wheelchair in Daily Life”(Research Project 25K05636).
摘要The purpose of this study was to clarify the effects of different sidewalk widths on the driving characteristics of electric wheelchairs and on the user’s psychology and safety.Eighteen participants drove electric wheelchairs on both wide and narrow sidewalks.Data collection included:(1)the number of cyclists and pedestrians passing by,(2)driving speed,(3)an 11-item questionnaire,and(4)a post-test ride interview.The results showed that the number of cyclists and pedestrians they passed and their driving speed were significantly higher on wide sidewalks.On the other hand,on narrow sidewalks,negative evaluations were frequently given,including the difficulty of avoiding steps,slopes,and utility poles,anxiety and psychological tension associated with pedestrian consideration,and difficulty in operation.These results indicate that sidewalk width is not just a physical space,but also an important environmental factor that strongly influences users’anxiety,operational burden,and distance adjustment from pedestrians.Creating a safe and comfortable mobility environment requires both improvements to sidewalk infrastructure and innovations in mobility devices.
基金funded by National Natural Science Foundation of China(No.31370587)
摘要Tree-ring width chronologies of Larix chinensis were developed from the northern and southern slopes of the Qinling Mountains in Shaanxi Province,and climatic factors affecting the tree-ring widths of L.chinensis were examined.Correlation analysis showed that similar correlations between tree-ring width chronologies and climatic factors demonstrated that radial growth responded to climate change on both slopes.The radial growth of L.chinensis was mainly limited by temperature,especially the growing season.In contrast,both chronologies were negatively correlated with precipitation in May of the previous year and April of the current year.Spatial climate-correlation analyses with gridded land-surface climate data revealed that our tree-ring width chronologies contained a strong regional temperature signal over much of northcentral and eastern China.Spatial correlation with seasurface temperature fields highlights the influence of the Pacific Ocean,Indian Ocean,and North Atlantic Ocean.Wavelet coherence analysis indicated the existence of some decadal and interannual cycles in the two tree-ring width chronologies.This may suggest the influences of El Nin˜o-Southern Oscillation and solar activity on tree growth in the Qinling Mountains.These findings will help us understand the growth response of L.chinensis to climate change in the Qinling region,and they provide critical information for future climate reconstructions based on this species in semi-humid regions.