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Extended venous excess ultrasound:A promising addition to pointof-care ultrasound-based venous congestion assessment 认领 引用 被引量：1
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作者 Abhilash Koratala 《World Journal of Cardiology》 2026年第1期95-105,共11页
Systemic congestion is increasingly recognized as a major contributor to organ dysfunction and adverse outcomes in patients with heart failure and in those at risk of fluid overload.The venous excess ultrasound(VExUS)... Systemic congestion is increasingly recognized as a major contributor to organ dysfunction and adverse outcomes in patients with heart failure and in those at risk of fluid overload.The venous excess ultrasound(VExUS)grading system,introduced in 2020,uses Doppler evaluation of the hepatic,portal,and intrarenal veins to quantify venous congestion at the bedside.While abnormal venous waveforms have been recognized for years,the formalization of VExUS has provided a structured and clinically meaningful framework,generating widespread academic interest with over 500 citations to date.This article blends current evidence with the author’s perspective to review the principles,strengths,and limitations of VExUS and to outline the emerging concept of extended VExUS(eVExUS).VExUS has practical limitations when standard windows are inaccessible or unreliable,such as in patients with cirrhosis,advanced kidney disease,or difficult body habitus.The eVExUS approach addresses these challenges by incorporating additional venous Doppler assessments,including the internal jugular,superior vena cava,femoral,and splenic veins,as well as grayscale-based internal jugular measurements to estimate right atrial pressure when inferior vena cava imaging is suboptimal.While eVExUS offers a more adaptable,individualized strategy,its clinical adoption is still in the early stages.Further studies are required to validate eVExUS,link its findings to patient outcomes,and inform the development of tailored imaging protocols for diverse patient populations. 展开更多
关键词 Point of care ultrasound Ultrasound Venous excess ultrasound Congestion Fluid overload Right atrial pressure Doppler Heart failure
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Endoscopic ultrasound-guided transhepatic antegrade stone removal for choledocholithiasis after pancreaticoduodenectomy:A case report and review of literature 认领 引用
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作者 Yu-Ming Li Aimaiti Yasen +4 位作者 Si-Fang Chen Jian Fan Xiao-Bing Huang Guo-Hua Zuo Lu Zheng 《World Journal of Gastroenterology》 SCIE CAS 2026年第8期146-153,共8页
BACKGROUND The special choledocholithiasis(common hepatic duct stone)proximal to hepaticojejunostomy anastomosis following pancreaticoduodenectomy(PD)presents significant therapeutic challenges because of surgically a... BACKGROUND The special choledocholithiasis(common hepatic duct stone)proximal to hepaticojejunostomy anastomosis following pancreaticoduodenectomy(PD)presents significant therapeutic challenges because of surgically altered anatomy,which precludes the use of conventional endoscopic retrograde cholangiopancreatography.Endoscopic ultrasound(EUS)offers a minimally invasive alternative for antegrade stone extraction.Here,we report a rare case of EUS-guided transhepatic antegrade stone removal(EUS-TASR)in a patient with choledocholithiasis occurring eleven years after PD.CASE SUMMARY A 58-year-old male with a history of PD for a duodenal tumor eleven years prior presented with a three-month history of intermittent upper abdominal discomfort.Imaging revealed a nodular filling defect in the common hepatic duct and mild intrahepatic biliary dilatation,confirming choledocholithiasis.Given the altered anatomy,endoscopic retrograde cholangiopancreatography was deemed unfeasible;thus,EUS-TASR with endoscopic nasobiliary drainage was successfully performed.The endoscopic nasobiliary drainage tube was removed on postoperative day 7,and the patient was discharged in stable condition on postoperative day 8.At the ten-month follow-up,the patient remained asymptomatic without complications.CONCLUSION EUS-TASR is a viable,minimally invasive approach for managing choledocholithiasis in post-PD patients with altered anatomy where conventional endoscopic access is restricted. 展开更多
关键词 Choledocholithiasis Pancreaticoduodenectomy Endoscopic ultrasound Endoscopic ultrasound-guided transhepatic antegrade stone removal Case report
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Multimodality ultrasound in Crohn’s disease strictures 认领 引用
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作者 Partha Pal Priyaranjan Kata +5 位作者 Mohammad Abdul Mateen Vamsi Krishna Ankam Deepak Lalan Jha Rajesh Gupta Manu Tandan Nageshwar Reddy Duvvur 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 2026年第1期170-184,共15页
BACKGROUND Stricture formation in Crohn’s disease(CD)poses a significant clinical challenge,often requiring differentiation between inflammatory and fibrotic components to guide appropriate therapy.AIM To evaluate th... BACKGROUND Stricture formation in Crohn’s disease(CD)poses a significant clinical challenge,often requiring differentiation between inflammatory and fibrotic components to guide appropriate therapy.AIM To evaluate the utility of multimodal intestinal ultrasound-including small intestine contrast ultrasonography(SICUS),contrast-enhanced ultrasound(CEUS),and ultrasound-based elastography-in detecting and characterizing CD-related small bowel strictures.METHODS A review was conducted in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.A comprehensive search of PubMed and EMBASE databases from inception to June 2025 yielded 697 records,respectively.After screening and full-text assessment,43 studies were included.Eligible studies reported on the use of SICUS,CEUS,and elastography for detecting or phenotyping CD strictures,with comparisons to cross-sectional imaging,histopathology,endoscopy,or surgical findings.RESULTS Across heterogeneous study designs,SICUS demonstrated high sensitivity for stricture detection(typically approximately 88%-98%)with specificity that varied by cohort and criteria.Common thresholds included bowel wall thickness>3 mm,luminal narrowing2.5 cm.CEUS effectively distinguished fibrotic from inflammatory strictures using time-intensity curve metrics:Fibrotic strictures showed reduced peak enhancement(e.g.,25 dB vs 38 dB),and lower perfusion area under the curve(AUC)values(e.g.,570 intensity time units vs 1168 intensity time units),reflecting diminished vascularity.Cutoffs such as peak enhancement<30 dB and AUC<700 units were associated with fibrosis.Elastography-particularly shear wave elastography achieved AUCs of 0.88-0.91 for fibrosis detection using cutoffs of 2.5-2.9 m/second(sensitivity 80%-88%,specificity 85%-100%).Strain ratio thresholds between 2.2 and 3.0 also differentiated fibrotic from inflammatory lesions with diagnostic AUCs up to 0.91.Among elastography modalities,shear wave elastography consistently outperformed strain elastography and acoustic radiation force impulse in accuracy and reproducibility.CONCLUSION Multimodal intestinal ultrasound-including SICUS,CEUS,and elastography-offers a comprehensive,radiationfree framework to detect,localize,and phenotype CD strictures.While performance is promising,variability in thresholds and reference standards limits generalizability.Standardized acquisition,predefined cut-offs,and multicenter validation are priorities before widespread adoption in treatment algorithms. 展开更多
关键词 Crohn’s disease Intestinal ultrasound Small intestine contrast ultrasonography Contrast-enhanced ultrasound Elastography
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Venous excess doppler ultrasound:What radiologists should know in 2026 认领 引用
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作者 Chail Shah Deepak Shah Abhilash Koratala 《World Journal of Radiology》 2026年第6期1-9,共9页
Systemic venous congestion is increasingly recognized as a key contributor to organ dysfunction and adverse outcomes,particularly in the cardiorenal and critical care settings.Elevated right-sided cardiac pressures ar... Systemic venous congestion is increasingly recognized as a key contributor to organ dysfunction and adverse outcomes,particularly in the cardiorenal and critical care settings.Elevated right-sided cardiac pressures are transmitted retrogradely to the hepatic,splanchnic,and renal venous systems,leading to impaired organ perfusion,increased interstitial pressure,and complications such as acute kidney injury.Conventional clinical markers and biomarkers of congestion lack sensitivity for detecting early or subclinical venous hypertension.In contrast,ultrasound,particularly when incorporating abdominal venous Doppler assessment,enables a more granular,physiologically grounded evaluation of congestion.The venous excess ultrasound(VExUS)score integrates inferior vena cava assessment with hepatic,portal,and intrarenal venous Doppler waveforms to provide a structured framework for grading venous congestion.VExUS has been associated with renal outcomes,and morbidity and mortality in heart failure,and dynamic changes in venous Doppler patterns appear to carry prognostic significance.This review describes the physiologic basis of venous Doppler abnormalities,outlines the components and grading of the VExUS system,and highlights common technical and interpretive pitfalls that affect reliable assessment.Particular emphasis is placed on waveform morphology,electrocardiographic correlation,and optimization of Doppler acquisition.Given that abdominal Doppler studies are frequently performed for indications unrelated to heart failure,radiologists are uniquely positioned to recognize venous congestion on routine imaging.Incorporation of VExUS principles into radiologic reporting,along with standardized acquisition and multidisciplinary education,may enhance the clinical relevance of abdominal and renal vascular examinations and support earlier, physiologically informed hemodynamic intervention. This narrative review synthesizes current evidence,discusses technical and interpretive considerations, and provides practical guidance for radiologists incorporatingVExUS into practice. 展开更多
关键词 Point-of-care ultrasound Ultrasound Venous excess ultrasound Congestion Radiology
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Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration:A new hope for noninvasive treatment of neurodegenerative diseases 认领 引用 被引量：2
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作者 Shu Xia Chen He +4 位作者 Yunfei Li Hao Li Bo Wang Long Xu Xudong Zhao 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第6期2300-2312,共13页
Neurodegenerative diseases,which are characterized by progressive neuronal loss and the lack of disease-modifying therapies,are becoming a major global health challenge.The existing neuromodulation techniques,such as ... Neurodegenerative diseases,which are characterized by progressive neuronal loss and the lack of disease-modifying therapies,are becoming a major global health challenge.The existing neuromodulation techniques,such as deep brain stimulation and transcranial magnetic stimulation,show limitations such as invasiveness,restricted cortical targeting,and irreversible tissue effects.In this context,low-intensity transcranial ultrasound has emerged as a promising noninvasive alternative that can penetrate deep into the brain and modulate neuroplasticity.This review comprehensively assesses the therapeutic mechanisms,efficacy,and translational potential of low-intensity transcranial ultrasound in treating neurodegenerative diseases,with emphasis on its role in promoting neuronal regeneration,modulating neuroinflammation,and enhancing functional recovery.We summarize the findings of previous studies and systematically illustrate the potential of low-intensity transcranial ultrasound in regulating cell death mechanisms,enhancing neural repair and regeneration,and alleviating symptoms associated with neurodegenerative diseases.Preclinical findings indicate that low-intensity transcranial ultrasound can enhance the release of neurotrophic factors(e.g.,brain-derived neurotrophic factor),promote autophagy to clear protein aggregates,modulate microglial activation,and temporarily open the blood-brain barrier to facilitate targeted drug delivery.Existing clinical trial data show that low-intensity transcranial ultrasound can reduce amyloid-βplaques,improve motor and cognitive deficits,and promote remyelination in various disease models.Early clinical trials suggest that low-intensity transcranial ultrasound may enhance cognitive scores in Alzheimer’s disease and alleviate motor symptoms in Parkinson’s disease,all while demonstrating a favorable safety profile.Past studies support the notion that by integrating safety,precision,and reversibility,low-intensity transcranial ultrasound can transform the treatment landscape for neurodegenerative disease.However,more advancements are necessary for future clinical application of low-intensity transcranial ultrasound,including optimizing parameters such as frequency,intensity,and duty cycle;considering individual anatomical differences;and confirming long-term efficacy.We believe establishing standardized protocols,conducting larger trials,and investigating the underlying mechanisms to clarify dose-response relationships and refine personalized application strategies are essential in this regard.Future research should focus on translating preclinical findings into clinical practice,addressing technical challenges,and exploring combination therapies with pharmacological or gene interventions. 展开更多
关键词 Alzheimer’s disease frontotemporal dementia low-intensity transcranial ultrasound multiple sclerosis multiple system atrophy neurodegenerative diseases neuromodulation neuronal regeneration Parkinson’s disease transcranial ultrasound stimulation
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Artificial intelligence in endoscopic ultrasound-guided biliary drainage:Emerging applications,technical challenges,and future directions 认领 引用
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作者 Ahmed Salman Ahmed Elewa +1 位作者 Ahmad Marwan Mohamed AbdAlla Salman 《World Journal of Translational Medicine》 2026年第2期51-59,共9页
Endoscopic ultrasound-guided biliary drainage(EUS-BD)has evolved from a rescue procedure following failed endoscopic retrograde cholangiopancreatography(ERCP)into an important therapeutic option for select patients wi... Endoscopic ultrasound-guided biliary drainage(EUS-BD)has evolved from a rescue procedure following failed endoscopic retrograde cholangiopancreatography(ERCP)into an important therapeutic option for select patients with biliary obstruction.However,EUS-BD remains technically demanding and highly operator-dependent,requiring accurate anatomical recognition,safe route selection,stable access,and precise stent deployment.Artificial intelligence(AI)has the potential to improve the safety,reproducibility,and efficiency of EUS-BD by supporting procedural decision making.This review discusses emerging AI applications in EUS-BD,including the prediction of ERCP failure,pre-procedural imaging assessment,drainage route selection,real-time EUS image interpretation,bile duct recognition,vessel avoidance,needle trajectory planning,device tracking,stent deployment support,adverse event prediction,and post-procedural follow-up.AI can further assist in training and quality assurance through anatomical labeling,procedural feedback,and objective performance assessment.However,direct evidence for AI-guided EUS-BD remains limited,and most AIEUS studies have focused on diagnostic rather than therapeutic applications.The major barriers include limited datasets,a lack of expert-labeled procedural videos,inadequate external validation,challenges in real-time integration,limited model explainability,and ethical and regulatory uncertainties.AI-assisted EUS-BD should therefore be considered as investigational rather than standard practice.Future progress requires multicenter validation studies and clinically meaningful evidence to demonstrate improved procedural performance and patient outcomes. 展开更多
关键词 Artificial intelligence Endoscopic ultrasound Endoscopic ultrasound-guided biliary drainage Therapeutic endoscopic ultrasound Biliary obstruction
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Therapeutic effects of low-intensity transcranial focused ultrasound stimulation on ischemic stroke in rats:An in vivo evaluation using electrical impedance tomography 认领 引用 被引量：1
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作者 Jiecheng Guo Sixuan He +4 位作者 Li Yan Lei Wang Xuetao Shi Huijing Hu Le Li 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第3期1183-1190,共8页
Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance to... Although previous studies have demonstrated that transcranial focused ultrasound stimulation protects the ischemic brain,clear criteria for the stimulation time window and intensity are lacking.Electrical impedance tomography enables real-time monitoring of changes in cerebral blood perfusion within the ischemic brain,but investigating the feasibility of using this method to assess post-stroke rehabilitation in vivo remains critical.In this study,ischemic stroke was induced in rats through middle cerebral artery occlusion surgery.Transcranial focused ultrasound stimulation was used to treat the rat model of ischemia,and electrical impedance tomography was used to measure impedance during both the acute stage of ischemia and the rehabilitation stage following the stimulation.Electrical impedance tomography results indicated that cerebral impedance increased after the onset of ischemia and decreased following transcranial focused ultrasound stimulation.Furthermore,the stimulation promoted motor function recovery,reduced cerebral infarction volume in the rat model of ischemic stroke,and induced the expression of brain-derived neurotrophic factor in the ischemic brain.Our results also revealed a significant correlation between the impedance of the ischemic brain post-intervention and improvements in behavioral scores and infarct volume.This study shows that daily administration of transcranial focused ultrasound stimulation for 20 minutes to the ischemic hemisphere 24 hours after cerebral ischemia enhanced motor recovery in a rat model of ischemia.Additionally,our findings indicate that electrical impedance tomography can serve as a valuable tool for quantitatively evaluating rehabilitation after ischemic stroke in vivo.These findings suggest the feasibility of using impedance data collected via electrical impedance tomography to clinically assess the effects of rehabilitatory interventions for patients with ischemic stroke. 展开更多
关键词 animal model brain stimulation electrical impedance tomography evaluation impedance noninvasive treatment real-time monitoring rehabilitation stroke transcranial focused ultrasound stimulation
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Mechanism by which low-intensity focused ultrasound promotes angiogenesis and neurogenesis after traumatic brain injury in a rat model via the OXA/MAPK signaling pathway 认领 引用 被引量：1
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作者 Bingkai Ren Junwei Kang +4 位作者 Peng Yao Lianghua Huang Yan Wang Yang Bai Zhen Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2026年第9期4297-4310,共14页
Low-intensity focused ultrasound is a type of ultrasound that primarily relies on cavitation and mechanical effects.It is non-invasive,transient,and well tolerated.Previous studies have confirmed that low-intensity fo... Low-intensity focused ultrasound is a type of ultrasound that primarily relies on cavitation and mechanical effects.It is non-invasive,transient,and well tolerated.Previous studies have confirmed that low-intensity focused ultrasound can reduce neuroinflammation after traumatic brain injury and exert neuroprotective effects.However,whether it can also induce angiogenesis and neurogenesis in the brain,as well as the underlying mechanisms,remains unclear.In this preclinical study,a rat model of traumatic brain injury was established using a controlled cortical impact device.The rats were then received 14 days of low-intensity focused ultrasound treatment targeting the thalamus.The results showed that low-intensity focused ultrasound effectively reduced cerebral edema and mitigated blood-brain barrier damage in rats with traumatic brain injury,leading to improved neurological function.Further investigation showed that low-intensity focused ultrasound significantly un-regulated Orexin-A/Orexin-A receptor 1 expression,and intraperitoneal administration of the Orexin-A receptor 1 inhibitor SB334867 prevented the neuroprotective effects of low-intensity focused ultrasound.Subsequent transcriptome sequencing revealed that low-intensity focused ultrasound activated the MAPK signaling pathway.Finally,in an in vitro cell injury model created using tumor necrosis factor-alpha,low-intensity focused ultrasound enhanced endothelial cell migration,stimulated angiogenesis,and supported hippocampal neuron migration and growth.Moreover,the MAPK signaling pathway inhibitor LY3214996 suppressed these effects.Taken together,our findings suggest that low-intensity focused ultrasound enhances angiogenesis and neurogenesis and improves neurological function following traumatic brain injury by regulating the expression of Orexin-A/Orexin-A receptor 1,which activates the MAPK signaling pathway. 展开更多
关键词 angiogenesis blood-brain barrier low-intensity focused ultrasound MAPK signaling pathway nerve repair neurogenesis neurological function orexin-A OX1R traumatic brain injury
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Ultrasound-induced Activation of Tetravalent Platinum Polyglutamate Nanoprodrug Accelerated by Coumarin Derivatives 认领 引用
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作者 Chao-Ying Kong Chu-Wen Luo +2 位作者 Ya-Jun Xu Na Shen Zhao-Hui Tang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第1期44-56,I0009,共13页
Given that platinum-based drugs are widely used clinically as chemotherapeutic agents,their severe toxic side effects have attracted significant attention.Consequently,the development of novel nanoprodrugs based on lo... Given that platinum-based drugs are widely used clinically as chemotherapeutic agents,their severe toxic side effects have attracted significant attention.Consequently,the development of novel nanoprodrugs based on low-toxicity tetravalent platinum(Pt(Ⅳ))com plexes holds substantial research value.Herein,we discovered that coumarin derivatives exhibit inherent antitumor efficacy and significantly enhance superoxide anion radicals(·O2-)generation in aqueous solutions under ultrasound(US)irradiation.Given that·O2-is known to mediate the reduction of Pt(Ⅳ)to divalent platinum(Pt(Ⅱ)),we engineered an US-responsive dual-drug nanoprodrug(P-cisPt(Ⅳ)@5-MOP).This nanoprodrug was prepared by covalently conjugating Pt(Ⅳ)and methoxy polyethylene glycol hydroxyl(m PEG-OH)to a poly(L-glutamic acid)(PLG)carrier,followed by encapsulating coumarin derivatives.Under low-intensity US irradiation(1.5 W/cm2,1 MHz,10 min),P-cisPt(Ⅳ)@5-MOP achieved a Pt(Ⅳ)reduction rate of 91.4%.Furthermore,upon US exposure,its half-maximal inhibitory concentration(IC50)against 4T1 breast cancer cells decreased dramatically from 25.7μmol/L to 0.1μmol/L.Remarkably,this system combined with US therapy yielded a tumor inhibition rate of 90.9%,with 40%of tumor-bea ring mice achieving com plete eradication of tumors,while exhibiting low systemic toxicity.Collectively,this work not only identifies a novel sonosensitizer capable of generating·O2-but also develops a new class of ultrasound-activatable Pt(Ⅳ)nanoprodrug. 展开更多
关键词 Ultrasound activation Ultrasound chemistry Platinum drug Coumarin Superoxide anion radical
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Sequential ultrasound-hot water extraction of Tradescantia zebrina leaves:optimized bioactivities with limited gastrointestinal stability 认领 引用
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作者 Wey-Loon Lim Fai-Chu Wong +1 位作者 Fazilah Abd Manan Tsun-Thai Chai 《Food Innovation and Advances》 2026年第1期37-44,共8页
Tradescantia zebrina is a leafy vegetable with potential as a functional food ingredient,but its optimal extraction and gastrointestinal(GI)stability require investigation.This study aimed to optimize phytochemical ex... Tradescantia zebrina is a leafy vegetable with potential as a functional food ingredient,but its optimal extraction and gastrointestinal(GI)stability require investigation.This study aimed to optimize phytochemical extraction from T.zebrina leaves using hot water extraction(HWE),ultrasound-assisted extraction(UAE),and sequential hybrid methods(UAE+HWE,HWE+UAE),and then evaluated the GI stability of the optimized extract using the INFOGEST model.Among nine extraction treatments,the sequential UAE-20 min followed by HWE-15 min(UAE-20+HWE-15)yielded the highest total phenolic content(TPC,8.11 mg GAE/g)and flavonoid content(TFC,63 mg QE/g),along with the strongest antioxidant activities:2,2-diphenyl-1-picrylhydrazyl(DPPH·)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)radical cation(ABTS·+)scavenging,and Ferric reducing antioxidant power(FRAP).TPC and TFC correlated strongly with antioxidant parameters,while anthocyanin contents did not.Post-digestion analysis of the optimized extract,following solid-phase extraction cleanup,revealed marked reductions in the phenolic and flavonoid content(to 3.28 mg GAE/g and 6.44 mg QE/g,respectively)and a corresponding decline in DPPH·,ABTS·+,and H2O2scavenging activities,FRAP,and anti-inflammatory(albumin denaturation inhibition)activities.Nitric oxide scavenging activity was nearly lost.These findings indicate that while the UAE-20+HWE-15 method is optimal for extraction,the resulting bioactive compounds showed limited stability under simulated GI conditions,highlighting the need for strategies to preserve their activity for functional food applications.This highlights the need for protective strategies,like encapsulation,to preserve its efficacy for functional food applications. 展开更多
关键词 ultrasound assisted extraction gi stability hot water extraction hot water extraction hwe ultrasound assisted sequential extraction sequential hybrid methods uae hwehwe uae infogest modelamong leafy vegetable
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Assessing predictive value of contrast-enhanced ultrasound combined with doppler ultrasound for post-transcatheter arterial chemoembolization prognosis in hepatocellular carcinoma 认领 引用
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作者 Jia-Jiao Qian Min Xu Yan-Song Ji 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第1期266-273,共8页
BACKGROUND Hepatocellular carcinoma(HCC)is a significant global health issue that is often diagnosed in advanced stages.Transcatheter arterial chemoembolization(TACE)is a standard intervention for unresectable HCC;how... BACKGROUND Hepatocellular carcinoma(HCC)is a significant global health issue that is often diagnosed in advanced stages.Transcatheter arterial chemoembolization(TACE)is a standard intervention for unresectable HCC;however,it is frequently followed by tumor recurrence,highlighting the need for reliable prognostic tools.This study evaluated the combined predictive value of contrast-enhanced ultrasound(CEUS)and Doppler ultrasound in assessing the clinical outcomes post-TACE.AIM To develop a comprehensive imaging strategy that can guide personalized treatment planning through an improved assessment of tumor vascularization and liver function,assess the predictive value of CEUS combined with Doppler ultrasound in patients with HCC who underwent TACE.METHODS This retrospective study analyzed 124 patients with HCC who underwent TACE.Based on 1-year outcomes,the patients were stratified into good(n=86)and poor(n=38)prognostic groups.We compared the clinical and ultrasound data(CEUS and Doppler parameters)between the groups to identify prognostic factors.Multivariate logistic regression was used to identify independent predictors,and receiver operating characteristic curve was used to evaluate the predictive power of the combined model for post-TACE prognosis.RESULTS Significant differences were observed between the two groups in terms of TNM stage,number of lesions,tumor size,arrival time(AT),washout time(WT),hepatic artery peak systolic velocity(VPs),portal vein velocity,and blood flow grading(P<0.05).Logistic regression analysis showed that TNM stage,tumor size,number of lesions,hepatic artery VPs,and blood flow grading were risk factors affecting the prognosis of patients with HCC following TACE,whereas AT,WT,and portal vein velocity were protective factors(P<0.05).Receiver operating characteristic curve analysis demonstrated that the area under the curve values for predicting post-TACE prognosis in patients with HCC were as follows:(1)0.704 for AT;(2)0.762 for WT;(3)0.796 for hepatic artery VPs;(4)0.796 for portal vein velocity;(5)0.657 for blood flow grading;and(6)0.942 for the combined model.CONCLUSION The combination of CEUS and Doppler ultrasound parameters,which reflect tumor vascularization and liver function,has high a predictive value for the prognosis of patients with HCC following TACE. 展开更多
关键词 Contrast-enhanced ultrasound Doppler ultrasound Hepatocellular carcinoma Transcatheter arterial chemoembolization Prognosis
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Ultra-high-frequency ultrasound in the detection of recurrent conjunctival melanoma:A case report 认领 引用
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作者 Anna Russo Vittorio Patanè +3 位作者 Maria Cristina Pezzella Teresa Troiani Giuseppe Argenziano Alfonso Reginelli 《World Journal of Clinical Cases》 2026年第4期60-67,共8页
BACKGROUND Conjunctival melanoma is rare and prone to local recurrence,and optimal surveillance imaging of the ocular surface and periocular skin is not standardized.We report the use of ultra-high-frequency ultrasoun... BACKGROUND Conjunctival melanoma is rare and prone to local recurrence,and optimal surveillance imaging of the ocular surface and periocular skin is not standardized.We report the use of ultra-high-frequency ultrasound(UHFUS)to map multiple clinically subtle recurrent nodules in a previously treated conjunctival melanoma(Co-M)patient undergoing immunotherapy.This case supports incorporating UHFUS into multidisciplinary follow-up,showing how it can non-invasively detect occult recurrence and guide staging and treatment planning.CASE SUMMARY A middle-aged patient with a history of conservatively treated left Co-M was referred for suspected local recurrence,reporting a new palpable subcutaneous lump near the lateral orbital rim and a pigmented lesion at the medial canthus of the same eye.Clinical examination confirmed a periocular nodule suggestive of relapse.Cervical lymph node ultrasound showed no suspicious lymphadenopathy.UHFUS(48 MHz)with Doppler of the periocular region revealed epidermal thickening at the medial canthus and three subepidermal nodules in the lower eyelid and lateral canthus,with irregular morphology and increased vascularity,highly suggestive of recurrent melanoma and satellite lesions.The patient was already receiving first-line anti-programmed cell death 1 immunotherapy;high-frequency ultrasound findings refined local staging,confirmed absence of nodal involvement,and supported multidisciplinary planning and imaging-based follow-up.CONCLUSION UHFUS can non-invasively detect and map recurrent Co-M,improving local staging and guiding multidisciplinary follow-up. 展开更多
关键词 High-frequency-ultrasound High-resolution imaging Melanoma Ultra-high-frequency ultrasound Conjunctival melanoma Case report
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An Ultrasound-Triggered Antibacterial Hydrogel With Integrated Antioxidant and Angiogenic Functions for Infected Wound Care 认领 引用
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作者 Jiayan Guo Ximeng Zhang +3 位作者 Bingran Qi Xingru Zhao Shi-Hang Zheng Kezhu Li 《Rare Metals》 SCIE EI CAS CSCD 2026年第5期204-219,共16页
Managing diabetic wounds requires simultaneously addressing their infectious,oxidative,and regenerative impairments.To address this,this study integrates a piezoelectric BiOCl@CuSe heterojunction(PFM-verified)into an ... Managing diabetic wounds requires simultaneously addressing their infectious,oxidative,and regenerative impairments.To address this,this study integrates a piezoelectric BiOCl@CuSe heterojunction(PFM-verified)into an injectable F127/HA hydrogel,creating an ultrasound-responsive smart dressing.Under ultrasound(US)irradiation,the hydrogel(F127/HA-BiOCl@CuSe)efficiently scavenged ROS such as·OH and·O2-via the piezoelectric catalytic effect.Meanwhile,the ultrasoundactivated hydrogel demonstrated an antibacterial rate of over 99%against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),and effectively disrupted bacterial biofilms.In vitro,the hydrogel demonstrated excellent biocompatibility and concurrently promoted endothelial cell migration and angiogenesis,as evidenced by upregulated Ang-1/VEGF expression and enhanced tube formation.It also effectively mitigated H2O2-induced oxidative stress and mitochondrial damage.In a diabetic mouse model of infected full-thickness wounds,the F127/HA-BiOCl@CuSe+ultrasound(US)group achieved the most rapid wound closure,potent bacterial clearance,and superior tissue regeneration within 12 days,marked by enhanced collagen deposition and attenuated inflammation.Collectively,this work presents a novel ultrasound-powered piezoelectric catalytic strategy for synergistic diabetic wound therapy. 展开更多
关键词 angiogenesis antibacterial therapy diabetic wound ROS scavenging ultrasound response
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Real-time Monitoring Unveils Three Distinct Neuronal Response Patterns to SAW Ultrasound via L-type Calcium Channels 认领 引用
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作者 Yiming Chen Wenxu Tang +10 位作者 Yifan Wang Ya Gao Jiaqi Hu Yixuan Lu Long Meng Hairong Zheng Yi Feng Liming Cheng Wenyong Fan Qian Cheng Lei Xue 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第1期75-90,共16页
Ultrasound neuromodulation shows promise for treating neurological disorders,but the underlying mechanisms remain unclear.Here,we developed an integrated surface acoustic wave(SAW)ultrasound chip enabling simultaneous... Ultrasound neuromodulation shows promise for treating neurological disorders,but the underlying mechanisms remain unclear.Here,we developed an integrated surface acoustic wave(SAW)ultrasound chip enabling simultaneous electrophysiological recording and Ca2+ imaging of cultured hippocampal neurons to investigate neuronal excitability and synaptic transmission during ultrasound stimulation.This study revealed,for the first time,three distinct neuronal response patterns induced by SAW ultrasound:an immediate response showing rapid activation,a delayed response exhibiting facilitation after several minutes,and a non-response maintaining baseline activity.Ultrasound stimulation increased action potential firing,enhanced excitatory postsynaptic currents,and elevated intracellular Ca2+ levels.These effects were dependent on extracellular Ca2+ influx and primarily dominated by L-type Ca2+ channels.Our findings suggest that individual neurons exhibit heterogeneous responses to SAW ultrasound stimulation based on their intracellular Ca2+ levels and L-type Ca2+ channel activity.This integrated approach provides new insights into the cellular mechanisms of ultrasound neuromodulation while highlighting the potential of SAW technology for precise,cell-type-specific neural control. 展开更多
关键词 Surface Acoustic Wave Ultrasound Neuromodulation Neuronal Excitability Synaptic Transmission Calcium Signaling
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Transparent high-frequency ultrasound transducer array for real-time interventional photoacoustic guidance 认领 引用
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作者 Junwei Wu Zhongwen Cheng +3 位作者 Chen Liang Yan Chen Lvming Zeng Xuanrong Ji 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第3期70-81,共12页
Photoacoustic tomography(PAT)provides both structural and functional information,making it a powerful tool for guiding interventional procedures.However,conventional ultrasound transducers are generally optically opaq... Photoacoustic tomography(PAT)provides both structural and functional information,making it a powerful tool for guiding interventional procedures.However,conventional ultrasound transducers are generally optically opaque,complicating PAT system design and hindering seamless integration with other optical imaging modalities.A novel transparent ultrasound transducer(TUT)linear array has been developed specifically for real-time interventional guidance.The TUT array-based PAT system demonstrates high performance with 378.2μm lateral resolution,599.1μm axial resolution,and a fast imaging rate of 0.05s/frame.The system’s interventional imaging capability was demonstrated through real-time visualization of needle morphology and dye diffusion during injections in chicken breast tissue.In summary,the TUT array enables potential applications in real-time multimodal imaging,combining photoacoustic,ultrasound,and optical modalities for comprehensive tissue characterization. 展开更多
关键词 Photoacoustic tomography transparent ultrasound transducer interventional guidance
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Enhancing genomic prediction for key production traits in chickens through ultrasound phenotyping and multi-model comparative analysis 认领 引用
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作者 Ranran Zhu Yuxiang Jiang +6 位作者 Wanyi Xiong Yu Zhang Ziyi Lian Danni Gou Zhandeng Li Xiuping Wang Xuemei Deng 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2026年第4期1958-1974,共17页
Background Growth performance and carcass traits are economically vital in poultry breeding.In Wenchang chickens,reducing excessive abdominal fat represents a critical breeding objective.However,as a typical carcass t... Background Growth performance and carcass traits are economically vital in poultry breeding.In Wenchang chickens,reducing excessive abdominal fat represents a critical breeding objective.However,as a typical carcass trait,abdominal fat thickness has traditionally been measurable only post-slaughter,resulting in inefficient and costly selection processes that hinder genetic progress for these traits.To overcome this limitation,we developed an integrated approach combining non-invasive ultrasound phenotyping and multi-model genomic selection to evaluate growth and fat-related traits in Wenchang chickens.Results We genotyped 3,737 chickens using the“Jingxin No.1”55K SNP array and performed longitudinal measurement of abdominal fat thickness(AFT)via ultrasound imaging.A comprehensive evaluation of genomic prediction models revealed that WGBLUP(informed by wssGWAS),and GBLUP models based on LD-pruned whole-genome sequencing(WGS)data significantly outperformed standard GBLUP,with accuracy gains of 5.25%and 6.58%–15.30%,respectively.Among the machine learning algorithms tested,kernel ridge regression(KRR)and support vector regression(SVR)achieved the highest predictive improvement(3.00%–4.15%)while maintaining superior computational efficiency,whereas ensemble methods provide no consistent advantage.Conclusions Our work established ultrasound imaging as a scalable,non-invasive phenotyping platform for poultry breeding.Results demonstrated that integrating wssGWAS-derived biological priors with WGS data substantially improves genomic prediction accuracy for complex traits.This integration,enhanced by computationally efficient machine learning algorithms,provides a powerful and practical strategy to accelerate genetic gain. 展开更多
关键词 Genomic prediction Machine learning Ultrasound phenotyping Wenchang chicken Whole-genome sequencing
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Rock strength assessment in tectonically deformed calcareous rocks integrating equotip,ultrasound velocity,and geo-structural fracture analysis 认领 引用
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作者 Elisa Mammoliti Danica Jablonská +3 位作者 Antonio Ferretti Michele Morici Stefano Mazzoli Mirko Francioni 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第1期196-213,共18页
In complex geological environments,the analysis of drill cores to determine rock strength can be challenging due to the wide variability in the degree of fracturing,leading to subjectivity in the collection of represe... In complex geological environments,the analysis of drill cores to determine rock strength can be challenging due to the wide variability in the degree of fracturing,leading to subjectivity in the collection of representative samples for uniaxial compressive strength testing.This study evaluates non-destructive techniques on calcareous rocks with different tectonic deformations,including Equotip hardness,ultrasound P-wave velocity,thin section analysis,and calcimetry,integrated with photogrammetric fracture analysis.The investigated carbonate rock samples are sourced from drill cores derived from the Umbria-Marche fold and thrust belt(northern Apennines,Italy),including a gently dipping limb of an anticline,a hinge zone of an anticline,and a fault zone associated with a thrust.Fracture intensity,quantified by the P21 parameter using photogrammetric techniques on pre-loading rock samples,is assessed alongside macroscopic identification of discontinuities(such as stylolites,veins,and joints)using marker colours to monitor failures during uniaxial compression testing.Empirical correlations depicted by single and multi-linear relationships indicate a strong dependence between the mechanical and physical properties of limestones.Both Equotip and P-wave velocity are influenced by fracture intensity,but P-wave velocity varies significantly with discontinuity orientation,especially at 45°-90°.To refine uniaxial compressive strength predictions and mitigate multicollinearity,statistical approaches,including linear and multilinear regression,Principal Component Analysis and Gaussian Process Regression,were tested.Findings improve the reliability of non-destructive techniques for assessing rock strength in structurally complex settings,with implications for geotechnical applications. 展开更多
关键词 Non-destructive testing Uniaxial compressive strength Equotip Ultrasound pulse velocity Fracturing Calcareous rocks
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Endoscopic ultrasound in early gastric cancer:Diagnostic accuracy and Tis/T1a lesion over staging risks 认领 引用
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作者 Xue-Yan Qiao Ze-Hua Li +1 位作者 Shi-Yong Lin Ge Wen 《World Journal of Gastroenterology》 SCIE CAS 2026年第7期75-82,共8页
BACKGROUND Accurate T-staging of early gastric cancer(EGC)is critical for selecting the most appropriate treatment strategy.Although the reported diagnostic performance of endoscopic ultrasound(EUS)in determining T st... BACKGROUND Accurate T-staging of early gastric cancer(EGC)is critical for selecting the most appropriate treatment strategy.Although the reported diagnostic performance of endoscopic ultrasound(EUS)in determining T stage varies among studies,it continues to serve as an important tool in the pretreatment assessment of EGC.AIM To identify clinicopathological factors that affect the diagnostic accuracy of EUS in EGC,with particular emphasis on mucosal lesions(Tis/T1a).METHODS We included EGC patients who underwent endoscopic resection or gastrectomy.The diagnostic accuracy of EUS was assessed by comparing its T-stage evaluation with the histopathological results of the resected specimens.Additionally,potential risk factors associated with the over staging of Tis/T1a lesions by EUS were investigated.RESULTS A total of 209 patients were included in this study.The overall diagnostic accuracy of EUS for T staging was 74.64%.However,the sensitivity of EUS in identifying Tis/T1a gastric cancers was relatively low at 41.25%.Risk factor analysis showed that younger age(P=0.035)and the presence of ulceration(P<0.001)were significantly associated with over staging of Tis/T1a lesions.In multivariate analysis,ulceration remained the only independent predictor of over staging,with an odds ratio of 15.25(95% confidence interval:3.23-71.98;P<0.001).CONCLUSION The accuracy of EUS for staging Tis/T1a early gastric cancer is markedly reduced when gastric ulceration is present.Therefore,EUS-based staging should be interpreted cautiously in patients with ulcer-related lesions. 展开更多
关键词 Endoscopic ultrasound Early gastric cancer Tumor staging Over staging Diagnostic accuracy
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Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma 认领 引用
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作者 Ruo-Bing Liu Jun-Yi Xin +1 位作者 Zhe Huang Kai-Yan Li 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第1期122-134,共13页
BACKGROUND The treatment technology of liver cancer is progressing.In addition to traditional surgical resection,combined therapies of immunotherapy based on immune checkpoint inhibitors,chemotherapy,and transcatheter... BACKGROUND The treatment technology of liver cancer is progressing.In addition to traditional surgical resection,combined therapies of immunotherapy based on immune checkpoint inhibitors,chemotherapy,and transcatheter arterial chemoembolization for hepatocellular carcinoma are more and more widely used.Accurate preoperative diagnosis of liver cancer will provide important information for comprehensive treatment and prognosis evaluation of liver cancer.Sonazoidcontrast-enhanced ultrasound is not only helpful for the qualitative diagnosis of liver lesions,but also has great potential in the diagnosis of histological differentiation of liver cancer.AIM To assess the differentiation of hepatocellular carcinoma(HCC)by utilizing the parameters and imaging features of Sonazoid-contrast-enhanced ultrasound(CEUS).METHODS A retrospective analysis was conducted on the CEUS data of 239 lesions through case-control study.These patients received Sonazoid-CEUS within one week before surgery and were confirmed as HCC by postoperative pathology.Within the cases,patients were further categorized into well-differentiated and poorlydifferentiated group.Time-intensity curves of the region of interest in both arterial and Kupffer phases were generated,allowing for the acquisition of quantitative parameters to assess the diagnostic efficacy in distinguishing lesions between these two groups and determining an appropriate cut-off value.RESULTS Univariate analysis showed that the absolute value of enhancement intensity(EIAV),intensity ratio(IR)and intensity difference(ID)in Kupffer phase were statistically different between the groups with different degree(P=0.015,P=0.000,P=0.000).The sensitivity and specificity were 40.2%,82.4%,80.4% and 78.1%,86.9% and 74.5%,respectively,for differentiating HCC lesions with EIAV≥56.384 dB,IR≥1.215 and ID≥9.184 dB.The area under the receiver operating characteristic curve were 0.590,0.877,0.815.There was no significant difference in the parameters of arterial phase,including peak time,initial growth time,rise time and the absolute value of peak intensity of lesions between the two groups(P>0.05).Multivariate analysis showed that the level of alphafetoprotein(AFP)and IR were risk factors for poor differentiation(P=0.001).CONCLUSION Among the parameters of Sonazoid-CEUS,IR in Kupffer phase exhibits superior diagnostic efficacy with high sensitivity and specificity in the diagnose of pathological differentiation of HCC.Combined with preoperative AFP level,a more accurate diagnosis will be obtained.Compared with portal vein phase,Kupffer phase showed the ability to identify HCC lesions more sensitive.These findings hold significant guiding implications and reference value for clinical practice. 展开更多
关键词 Contrast-enhanced ultrasound Hepatocellular carcinoma Quantitative parameters Kupffer phase Pathological differentiation
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Glomerulonephritis through the lens of ultrasound and radiology 认领 引用
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作者 Guido Gembillo Salvatore Silipigni +9 位作者 Concetto Sessa Lorenzo Lo Cicero Luca Soraci Annalisa Cozza Rocco Bruccoleri Luigi Peritore Walter Morale Andrea Corsonello Antonio Bottari Domenico Santoro 《World Journal of Nephrology》 2026年第2期59-77,共19页
Renal biopsy remains the diagnostic reference in glomerulonephritis,and no imaging modality has displaced its central role.The key question is whether imaging can complement histology by providing additional informati... Renal biopsy remains the diagnostic reference in glomerulonephritis,and no imaging modality has displaced its central role.The key question is whether imaging can complement histology by providing additional information on disease activity,prognosis,and treatment response.In clinical practice,conventional ultrasound is the first-line examination.Cortical thinning and elevated intrarenal resistive indices mainly reflect chronic structural damage and haemodynamic adaptation,without identifying the underlying pathological subtype.Techniques such as shear-wave elastography and contrast-enhanced ultrasound attempt to extend assessment beyond morphology by evaluating tissue stiffness and microvascular perfusion,with reported associations with fibrosis in immunoglobulin A nephropathy and microvascular changes in lupus nephritis and membranous nephropathy.Quantitative approaches integrating imaging features with clinical variables have also been explored for fibrosis staging,although broader validation remains limited.Computed tomography and magnetic resonance imaging continue to play a largely structural role,particularly in systemic diseases with renal involvement such as immunoglobulin G4-related nephropathy and vasculitis.Multiparametric magnetic resonance imaging can additionally assess perfusion and tissue microstructure through diffusion-weighted imaging,arterial spin labelling,and blood oxygenation level-dependent sequences.Nuclear medicine techniques may provide complementary molecular information,with exploratory applications in the assessment of inflammatory activity in antineutrophil cytoplasmic antibodies-associated vasculitis and in the evaluation of cortical or fibrotic involvement using newer tracers.Overall,evidence remains heterogeneous,and histological evaluation continues to determine diagnosis and guide treatment. 展开更多
关键词 Chronic kidney disease Glomerulonephritis Ultrasonography Renal biopsy Renal perfusion Contrast-enhanced ultrasound Lupus nephritis Elastography Magnetic resonance imaging Renal fibrosis
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