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One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery 认领 引用 被引量：2
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作者 Xingqun Pu Rongrong Liu +9 位作者 Yuting Xie Chenjing Yang Jingyi Chen Baoling Guo Chun-Xia Zhao Peng Zhao Jian Ruan Fangfu Ye David A Weitz Dong Chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第3期345-350,共6页
Biocompatible amphiphilic nanoparticles(NPs)with tunable particle morphology and surface property are important for their applications as functional materials.However,previously developed methods to prepare amphiphili... Biocompatible amphiphilic nanoparticles(NPs)with tunable particle morphology and surface property are important for their applications as functional materials.However,previously developed methods to prepare amphiphilic NPs generally involve several steps,especially an additional step for surface modification,greatly hindering their largescale production and widespread applications.Here,a versatile one-step strategy is developed to prepare biocompatible amphiphilic dimer NPs with tunable particle morphology and surface property.The amphiphilic dimer NPs,which consist of a hydrophobic shellac bulb and a hydrophilic poly(lactic acid)(PLA)bulb with PLA-poly(ethylene glycol)(PEG)on the bulb surface,are prepared in a single step by controlled co-precipitation and self-assembly.Amphiphilic PLA-PEG/shellac dimer NPs demonstrate excellent tunability in particle morphology,thus showing good performances in controlling the interfacial curvature and emulsion type.In addition,temperatureresponsive PLA-poly(N-isopropyl acrylamide)(PNIPAM)/shellac dimer NPs are prepared following the same method and emulsions stabilized by them show temperature-triggered response.The applications of PLA-PEG-folic acid(FA)/shellac dimer NPs for drug delivery have also been demonstrated,which show a very good performance.The strategy of preparing the dimer NPs is green,scalable,facile and versatile,which provides a good platform for the design of dimer NPs with tunable particle morphology and surface property for diverse applications. 展开更多
关键词 Janus particle Amphiphilic particle Dimer particle Colloidal surfactant Pickering emulsion Drug delivery
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Heterogeneous global responses of dust to wildfires explained by ecosystems’differing moisture-holding capacity 认领 引用
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作者 Qianqian Yang Meng Gao 《Science Bulletin》 SCIE EI CAS CSCD 2026年第12期2986-2990,共5页
Mineral dust ranks among the most prevalent aerosols globally by mass[1],representing a substantial environmental concern with broad impacts on human health[2],biogeochemical processes[3],and the climate system[1].Dus... Mineral dust ranks among the most prevalent aerosols globally by mass[1],representing a substantial environmental concern with broad impacts on human health[2],biogeochemical processes[3],and the climate system[1].Dust emissions originate from natural desert areas,characterized by sparse vegetation and easily erodible surfaces that facilitate particle mobilization,as well as from anthropogenically disturbed regions,affected by agricultural expansion,overgrazing,and deforestation. 展开更多
关键词 mineral dust ecosystems aerosols anthropogenically disturbed regionsaffected dust emissions moisture holding capacity environmental concern human health
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National assessment reveals widespread wind farm impacts on land surface temperature and vegetation in China 认领 引用
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作者 Ziyan Li Yan Li +8 位作者 Yingzuo Qin Laibao Liu Eviatar Bach Alona Armstrong Guoqing Li Mingquan Li Zheng Wang Yongqing Bai Zhengchao Chen 《Geography and Sustainability》 CSCD 2026年第3期202-212,共11页
The rapid development of wind energy in China since 2000 has raised concerns about its impacts on local climate and vegetation.Despite regional and local studies,a comprehensive national assessment is lacking.Here,we ... The rapid development of wind energy in China since 2000 has raised concerns about its impacts on local climate and vegetation.Despite regional and local studies,a comprehensive national assessment is lacking.Here,we analyzed the effects of 675 onshore wind farms,representing>90,000 identified wind turbines in China,on land surface temperature(LST)and vegetation using Moderate-resolution Imaging Spectroradiometer(MODIS)satellite data from 2003 to 2022.We found a daytime cooling effect of-0.05±0.48℃(mean±STD)and a nighttime warming effect of 0.06±0.28℃across all wind farms.The construction of wind farm infrastructure initially reduced peak normalized difference vegetation index(NDVI)by-0.006±0.036,and this adverse impact weakened over time(-0.004 after 7 years),indicating vegetation recovery.The wind farm impacts varied by land cover type.The nighttime warming was largest for barren lands(0.19℃),followed by croplands(0.10℃),grasslands(0.07℃),and forests(0.01℃).These differences contributed to increasing night warming from southern to northern China.The adverse vegetation impacts were largest for forests(-0.010),followed by grasslands(-0.008)and barren lands(-0.003),with croplands(0.001)being almost unaffected.Correlation analysis identified precipitation and mean LST as significant factors influencing spatial variations in nighttime LST impact,with greater vegetation decline reinforcing night warming.Our large-scale analysis provides comprehensive evidence of the heterogeneous environmental impacts of wind farms across China,informing the sustainable development of wind energy. 展开更多
关键词 Wind farm LST Vegetation Land cover NDVI Environmental impact
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Scalable fabrication and active site identification of MOF shell-derived nitrogen-doped carbon hollow frameworks for oxygen reduction 认领 引用 被引量：7
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作者 Jiashen Meng Ziang Liu +6 位作者 Xiong Liu Wei Yang Lianzhou Wang Yan Li Yuan-Cheng Cao Xingcai Zhang Liqiang Mai 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第7期186-192,共7页
Nitrogen-doped carbon materials as promising oxygen reduction reaction(ORR) electrocatalysts attract great interest in fuel cells and metal-air batteries because of their relatively high activity, high surface area, h... Nitrogen-doped carbon materials as promising oxygen reduction reaction(ORR) electrocatalysts attract great interest in fuel cells and metal-air batteries because of their relatively high activity, high surface area, high conductivity and low cost. To maximize their catalytic efficiency, rational design of efficient electrocatalysts with rich exposed active sites is highly desired. Besides, due to the complexity of nitrogen species, the identification of active nitrogen sites for ORR remains challenging. Herein, we develop a facile and scalable template method to construct high-concentration nitrogen-doped carbon hollow frameworks(NC), and reveal the effect of different nitrogen species on theirORRactivity on basis of experimental analysis and theoretical calculations. The formation mechanism is clearly revealed, including low-pressure vapor superassembly of thin zeolitic imidazolate framework(ZIF-8) shell on ZnO templates,in situ carbonization and template removal. The obtained NC-800 displays better ORR activity compared with other NC-700 and NC-900 samples. Our results indicate that the superior ORR activity of NC-800 is mainly attributed to its content balance of three nitrogen species. The graphitic N and pyrrolic N sites are responsible for lowering the working function, while the pyridinic N and pyrrolic N sites as possible active sites are beneficial for increasing the density of states. 展开更多
关键词 MOF shell Nitrogen-doped carbon Hollow framework Oxygen reduction Active nitrogen sites
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Visualization of adaptive polymer flow and displacement in medium-permeable 3D core-on-a-chip 认领 引用 被引量：1
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作者 Yan Zhang Xue-Zhi Zhao +3 位作者 Pei-Hui Han Li-Yuan Zhang David A.Weitz Yu-Jun Feng 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期1018-1029,共12页
Polymer flooding has been witnessed an effective technology for enhancing oil recovery from medium-to low-permeability reservoirs;however, direct visualization of polymer solution flow in such reservoir condition is s... Polymer flooding has been witnessed an effective technology for enhancing oil recovery from medium-to low-permeability reservoirs;however, direct visualization of polymer solution flow in such reservoir condition is still lacking. In this work, a three-dimensional (3D) core-on-a-chip device with a permeability of around 200 mD was prepared and employed to visualize the pore-scale flow and displacement of a self-adaptive polymer (SAP, 8.7 × 106 g·mol−1)−whose microscopic association structure and macroscopic viscosity can reversibly change in response to shear action−versus partially hydrolyzed polyacrylamide (HPAM), by recording their flow curves, monitoring dynamic transportation process via particle imaging velocimetry, and building 3D structure of remaining oil. The results show that, in single-phase flow, all polymer solutions exhibit flow thinning and then thickening regions as flow rate increases, but the transition between two regimes occurs at a small Weissenberg number (10−3−10−1) in this medium-permeable condition. In contrast to HPAM-1 with close weight-average molecular weight (Mw), the adaptive character not only extends SAP's shear-govern region, allowing SAP to propagate piece by piece and achieve higher accessible pore volume, but it also enhances the elastic resistibility of polymer in the extension-dominated regime, increasing the microscopic displacement efficiency. These two effects result in 1.5–3 times more oil recovery factor for SAP than for HPAM-1. Regarding ultra-high-Mw HPAM-2 (25 × 106 g·mol−1), plugging and chain degradation do occur, thus producing lower oil recovery than SAP. This work provides a direct approach for in-situ assessment of polymer-based displacing system under a more authentic condition of practical reservoirs. 展开更多
关键词 Polymer flooding Medium-permeable transparent media Adaptive polymer In-situ rheology Particle imaging velocimetry
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A Hybrid Pre-Assessment Assists in System Optimization to Convert Face Masks into Carbon Nanotubes and Hydrogen 认领 引用
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作者 Hewen Zhou Sunwen Xia +11 位作者 Qing Yang Chao Liu Bo Miao Ning Cai Ondrej Masek Pietro Bartocci Francesco Fantozzi Huamei Zhong Wang Lu Qie Sun Haiping Yang Hanping Chen 《Engineering》 SCIE EI CSCD 2025年第4期204-212,共9页
With extensive attention being paid to the potential environmental hazards of discarded face masks,catalytic pyrolysis technologies have been proposed to realize the valorization of wastes.However,recent catalyst sele... With extensive attention being paid to the potential environmental hazards of discarded face masks,catalytic pyrolysis technologies have been proposed to realize the valorization of wastes.However,recent catalyst selection and system design have focused solely on conversion efficiency,ignoring economic cost and potential life-cycle environmental damage.Here,we propose an economic-environmental hybrid pre-assessment method to help identify catalysts and reactors with less environmental impact and high economic returns among various routes to convert discarded face masks into carbon nanotubes(CNTs)and hydrogen.In catalyst selection,it was found that a widely known Fe-Ni catalyst exhibits higher catalytic activity than a cheaper Fe catalyst,potentially increasing the economic viability of the catalytic pyrolysis system by 38%-55%.The use of this catalyst also results in a carbon reduction of 4.12-10.20kilogram CO2 equivalent for 1 kilogram of discarded face masks,compared with the cheaper Fe catalyst.When the price of CNTs exceeds 1.49×104 USD·t-1,microwave-assisted pyrolysis is the optimal choice due to its superior environmental performance(in terms of its life-cycle greenhouse gas reduction potential,eutrophication potential,and human toxicity)and economic benefits.In contrast,conventional heating pyrolysis may be a more economical option due to its good stability over 43 reaction regeneration cycles,as compared with a microwave-assisted pyrolysis catalyst with a higher conversion efficiency.This study connects foundational science with ecological economics to guide emerging technologies in their research stage toward technical efficiency,economic benefits,and environmental sustainability. 展开更多
关键词 Face mask Catalytic pyrolysis Carbon nanotubes Life-cycle assessment Economic analysis
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A new method to determine the synergistic effects of area ratio and microstructure on the galvanic corrosion of LAS A508/309 L/308 L SS dissimilar metals weld 认领 引用 被引量：5
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作者 Bright O.Okonkwo Hongliang Ming +4 位作者 Jianqiu Wang En-Hou Han Ehsan Rahimi Ali Davoodi Saman Hosseinpour 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第19期38-50,共13页
The synergistic effects of area ratio and microstructure on the galvanic corrosion of A508/309 L/308 L dissimilar metals weld(DMW)are studied by a multi-analytical approach.It was demonstrated that decreasing the anod... The synergistic effects of area ratio and microstructure on the galvanic corrosion of A508/309 L/308 L dissimilar metals weld(DMW)are studied by a multi-analytical approach.It was demonstrated that decreasing the anode/cathode surface area ratio obviously enhances the corrosion rate of A508,both locally and globally.Deeper analyses of the AFM results enabled quantitative comparison of the corrosion behaviour of the different surface constituents.It was revealed that in the galvanic interaction of the DMW,the grain refined region corrodes most,followed by the partial grain refined region and base metal matrix of the A508,respectively.The electrochemical localization index(LI)estimation method and AFM analysis both confirmed the presence of a mixed(localized and uniform)corrosion phenomenon occurring on the surface of the A508 anode metal in the galvanic interaction of the dissimilar metals.Finally,the degree of synergism equation was utilized to describe the synergistic effects of anode/cathode area ratio and the microstructure of the samples on the galvanic corrosion of LAS A508/309 L/308 L SS DMW. 展开更多
关键词 Low alloy steel Stainless steel SEM AFM Galvanic corrosion Inclusion
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First Principles Study on the Stability and Mechanical Properties of MB(M=V,Nb and Ta)Compounds 认领 引用 被引量：1
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作者 QI Chen-Jin FENG Jing +2 位作者 ZHOU Rong-Feng JIANG Ye-Hua ZHOU Rong 《Chinese Physics Letters》 SCIE EI CAS CSCD 2013年第11期144-148,共5页
The first principles calculations based on density functional theory are performed to investigate the stability,chemical bonding,elastic constants,hardness and Debye temperature of MB(M=V,Nb and Ta)compounds.The struc... The first principles calculations based on density functional theory are performed to investigate the stability,chemical bonding,elastic constants,hardness and Debye temperature of MB(M=V,Nb and Ta)compounds.The structures of these borides are optimized,and the lattice parameters are in good agreement with the experimental data.The calculated cohesive energy and formation enthalpy indicate that they are of a thermodynamically stable structure.The mechanical properties,including elastic constants Cij,bulk modulus,Young's modulus,shear modulus and Poisson's ratio,are calculated.The bulk moduli of them ranging from 263.0 to 278.4 GPa are larger than many common Laves phases and TaB with 278.4 GPa being the largest bulk modulus value among them.The population analysis is used to analyze the chemical bonds in these compounds.The hardness of the compounds is also evaluated,and the result reveals that TaB is the hardest compound among them.The Debye temperature of MB is calculated.The results show that the values of MB compounds range from 419.3 to 794.3 K. 展开更多
关键词 compounds structure modulus
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Future Ultrafast Charging Stations for Electric Vehicles in China:Charging Patterns,Grid Impacts and Solutions,and Upgrade Costs 认领 引用 被引量：2
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作者 Yang Zhao Xinyu Chen +2 位作者 Peng Liu Chris P.Nielsen Michael B.McElroy 《Engineering》 SCIE EI CSCD 2025年第5期309-322,共14页
In China,electric vehicle(EV)fast-charging power has quadrupled in the past five years,progressing toward 10-minute ultrafast charging.This rapid increase raises concerns about the impact on the power grid including i... In China,electric vehicle(EV)fast-charging power has quadrupled in the past five years,progressing toward 10-minute ultrafast charging.This rapid increase raises concerns about the impact on the power grid including increased peak power demand and the need for substantial upgrades to power infrastruc-ture.Here,we introduce an integrated model to assess fast and ultrafast charging impacts for represen-tative charging stations in China,combining real-world charging patterns and detailed station optimization models.We find that larger stations with 12 or more chargers experience modest peak power increases of less than 30%when fast-charging power is doubled,primarily because shorter charg-ing sessions are less likely to overlap.For more typical stations(e.g.,8-9 chargers and 120 kW·charger−1),upgrading chargers to 350-550 kW while allowing managed dynamic waiting strategies(of∼1 minute)can reduce overall charging times to∼9 minutes.At stations,deploying battery storage and/or expanding transformers can help manage future increases in station loads,yet the primary device cost of the former is∼4 times higher than that of the latter.Our results offer insights for charging infrastructure planning,EV-grid interactions,and associated policymaking. 展开更多
关键词 Electric vehicle Ultrafast charging Grid impact Charging infrastructure Upgrade cost
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Large-area photonic circuits for terahertz detection and beam profiling 认领 引用
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作者 Alessandro Tomasino Amirhassan Shams-Ansari +1 位作者 Marko Lončar Ileana-Cristina Benea-Chelmus 《Light: Science & Applications》 SCIE EI CAS CSCD 2026年第1期218-230,共13页
Deployment of terahertz communication and spectroscopy systems relies on the availability of low-noise and fast detectors,with plug-and-play capabilities.However,most current technologies are stand-alone,discrete comp... Deployment of terahertz communication and spectroscopy systems relies on the availability of low-noise and fast detectors,with plug-and-play capabilities.However,most current technologies are stand-alone,discrete components.They are often slow or susceptible to temperature drifts and require tight beam focusing to maximize the signal-tonoise of the detector.Here,we demonstrate an integrated photonic architecture in thin-film lithium niobate that addresses these challenges by exploiting the electro-optic modulation induced by a terahertz signal onto an optical beam at telecom frequencies.Leveraging on the low optical losses provided by this platform,we integrate a double array of up to 18 terahertz antennas within a Mach-Zehnder interferometer,considerably extending the device collection area and boosting the interaction efficiency between the terahertz signal and the optical beam.We show that the double array coherently builds up the probe modulation through a mechanism of quasi-phase-matching,driven by a periodic terahertz near-field pattern,circumventing physical inversion of the crystallographic domains.This provides means to fully custom-tailor the frequency response of the device,limit it to a desired frequency band and effectively suppress out-of-band signals.The large detection area ensures correct operation with diverse terahertz beam settings.Furthermore,we show that the antennas act as pixels that allow reconstruction of the terahertz beam profile impinging on the detector area.Our on-chip design in thin-film lithium niobate overcomes the detrimental effects of two-photon absorption and fixed phase-matching conditions,which have plagued previously explored electro-optic detection systems,especially in the telecom band,paving the way for more advanced on-chip terahertz systems. 展开更多
关键词 Mach Zehnder interferometer integrated photonic architecture beam profiling photonic circuits terahertz detection electro optic modulation tight beam focusing lithium niobate
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Green staggered traveling-surface Rayleigh acoustic wave microchips for additive-free cell lysis 认领 引用
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作者 Haiwei Lu Rui Wang +7 位作者 Lavonda Li Shichao Ding Lijie Yan Senlin Wang Chaohui Wang Tengfei Zheng Junying Sun Xingcai Zhang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2026年第3期501-513,I0004,共13页
Efficient coupling between acoustic fields and fluid microenvironments is crucial for advancing applied physics and microfluidic engineering in advanced biomedical,environmental sustainability,and broader industrial a... Efficient coupling between acoustic fields and fluid microenvironments is crucial for advancing applied physics and microfluidic engineering in advanced biomedical,environmental sustainability,and broader industrial applications.Harnessing such interactions for biological processing enables the precise,contactless,and tunable control of cell membrane disruption,facilitating reagent-free,contamination-minimized lysis.However,existing acoustic lysis devices are faced with challenges of limited efficiency and intricate structures.To overcome these limitations,we developed a staggered traveling-surface Rayleigh acoustic wave(STRAW)microchip for additive-free cell lysis.The device consists of a LiNbO3substrate patterned with two sets of interdigital transducers and a circular polydimethylsiloxane ring for confining cell suspension.We constructed a mathematical model for the STRAW-induced mechanical effects and optimized the alignment of interdigital transducers via theoretical modeling and finite-element analysis to maximize torque and acoustic streaming.The proposed STRAW-based platform showed over 95%lysis efficiency within 30 s for MC3T3-E1 mammalian cells,Gram-negative Escherichia coli,and Gram-positive Staphylococcus aureus.Thus,the developed design enables additive-free,structurally straightforward acoustic lysis with demonstrated compatibility across the tested cell types.Beyond basic lysis,this universal platform can be used in point-of-care diagnostics and food and environmental safety monitoring.This work illustrates how fluid structure-wave interactions may inform fluid mechanics and applied physics within a high-performance,low-complexity microfluidic system,paving the way for the widespread integration of STRAW-induced acoustic streaming in diagnostics,industry,and research. 展开更多
关键词 Staggered traveling-surface Rayleigh acoustic wave(STRAW) Acoustic streaming Microfluidics Microchip for additive-free cell lysis(MAC) Sustainability
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Photoluminescence evolution in self-ion-implanted and annealed silicon 认领 引用 被引量：16
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作者 杨宇 王茺 +3 位作者 杨瑞东 李亮 熊飞 Bao Ji-Ming 《Chinese Physics B》 SCIE EI CAS 2009年第11期4906-4911,共6页
Si^＋ ion-implanted silicon wafers are annealed at different temperatures from room temperature to 950℃ and then characterized by using the photoluminescence （PL） technique at different recorded temperatures （RETs... Si^＋ ion-implanted silicon wafers are annealed at different temperatures from room temperature to 950℃ and then characterized by using the photoluminescence （PL） technique at different recorded temperatures （RETs）. Plentiful optical features are observed and identified clearly in these PL curves. The PL spectra of these samples annealed in different temperature ranges are correspondingly dominated by different emission peaks. Several characteristic features, such as an R line, S bands, a W line, the phonon-assistant WTA and SiTO peaks, can be detected in the PL spectra of samples annealed at different temperatures. For the samples annealed at 800℃, emission peaks from the dislocations bounded at the deep energy levels of the forbidden band, such as D1 and D2 bands, can be observed at a temperature as high as 280 K. These data strongly indicate that a severe transformation of defect structures could be manipulated by the annealing and recorded temperatures. The deactivation energies of the main optical features are extracted from the PL data at different temperatures. 展开更多
关键词 photoluminescence silicon self-ion-implanted defects
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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease 认领 引用 被引量：11
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作者 Dandan Chu Mengyang Zhao +8 位作者 Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第6期439-457,共19页
Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Alt... Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases. 展开更多
关键词 Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine
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Three-dimensional bioprinting of gelatin methacryloyl (GelMA) 认领 引用 被引量：18
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作者 Guoliang Ying Nan Jiang +1 位作者 Cunjiang Yu Yu Shrike Zhang 《Bio-Design and Manufacturing》 SCIE EI CAS 2018年第4期215-224,共10页
The three-dimensional (3D)bioprinting technology has progressed tremendously over the past decade.By controlling the size, shape,and architecture of the bioprinted constructs,3D bioprinting allows for the fabrication ... The three-dimensional (3D)bioprinting technology has progressed tremendously over the past decade.By controlling the size, shape,and architecture of the bioprinted constructs,3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural-functional similarity with their in vivo counterparts at high fidelity.The bioink,a blend of biomaterials and living cells possessing both high biocompatibility and printability,is a critical component of bioprinting.In particular, gelatin methacryloyl (GelMA)has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical properties.Current GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed. 展开更多
关键词 Bioprinting Bioink Gelatin methacryloyl (GelMA) Biofabrication -Tissue engineering Tissue model
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Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy 认领 引用 被引量：14
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作者 Di Gao Ting Chen +13 位作者 Shuojia Chen Xuechun Ren Yulong Han Yiwei Li Ying Wang Xiaoqing Guo Hao Wang Xing Chen Ming Guo Yu Shrike Zhang Guosong Hong Xingcai Zhang Zhongmin Tian Zhe Yang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第6期311-331,共21页
Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“prec... Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“precise strike”of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid(HA)and hypoxia-dependent factor carbonic anhydrase IX(CA IX)-inhibitor acetazolamide(AZ).The core of nanobullets is the special zinc(II)phthalocyanine aggregates(ZPA)which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy(PTT),along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy(TDT).The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional(reactive oxygen species(ROS)-mediated)cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis. 展开更多
关键词 Photothermal therapy(PTT) Thermodynamic therapy(TDT) Targeting hybrid nanobullet Hypoxia tumor Zinc phthalocyanine aggregate(ZPA)
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From Bench to the Clinic:The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines 认领 引用 被引量：13
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作者 Diana O.Lopez‑Cantu Xichi Wang +4 位作者 Hector Carrasco‑Magallanes Samson Afewerki Xingcai Zhang Joseph V.Bonventre Guillermo U.Ruiz‑Esparza 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第3期1-31,共31页
During the last decades,the use of nanotechnology in med icine has effectively been translated to the design of drug delivery systems,nanostructured tissues,diagnostic platforms,and novel nanomaterials against several... During the last decades,the use of nanotechnology in med icine has effectively been translated to the design of drug delivery systems,nanostructured tissues,diagnostic platforms,and novel nanomaterials against several human diseases and infectious pathogens.Nanotechnology-enabled vaccines have been positioned as solutions to mitigate the pandemic outbreak caused by the novel pathogen severe acute respiratory syndrome coronavirus 2.To fast-track the development of vaccines,unprecedented industrial and academic collaborations emerged around the world,resulting in the clinical translation of effective vaccines in less than one year.In this article,we provide an overview of the path to translation from the bench to the clinic of nanotechnology-enabled messenger ribonucleic acid vaccines and examine in detail the types of delivery systems used,their mechanisms of action,obtained results during each phase of their clinical development and their regulatory approval process.We also analyze how nanotechnology is impacting global health and economy during the COVID-19 pandemic and beyond. 展开更多
关键词 Nanovaccines mRNA Coronavirus SARS-CoV-2 COVID-19
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Bioresource Upgrade for Sustainable Energy,Environment,and Biomedicine 认领 引用 被引量：9
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作者 Fanghua Li Yiwei Li +13 位作者 KSNovoselov Feng Liang Jiashen Meng Shih‑Hsin Ho Tong Zhao Hui Zhou Awais Ahmad Yinlong Zhu Liangxing Hu Dongxiao Ji Litao Jia Rui Liu Seeram Ramakrishna Xingcai Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第3期48-97,共50页
We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).... We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).We acme energy-efficient technologies for sustainable energy and material recovery and applications.The technologies of thermochemical conversion(TC),biochemical conversion(BC),electrochemical conversion(EC),and photochemical conversion(PTC)are summarized for HALUB.Microalgal biomass could contribute to a biofuel HHV of 35.72 MJ Kg-1and total benefit of 749$on biomass via TC.Specific surface area of biochar reached 3000 m2g-1via pyrolytic carbonization of waste bean dregs.Lignocellulosic biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%.Besides,lignocellulosic biomass can contribute to a current density of 672 mA m-2via EC.Bioresource can be 100%selectively synthesized via electrocatalysis through EC and PTC.Machine learning,techno-economic analysis,and life cycle analysis are essential to various upgrading approaches of HALUB.Sustainable biomaterials,sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis,microfluidic and microanomotors beyond are also highlighted.New techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed. 展开更多
关键词 High availability low utilization biomass(HALUB) Circular economy Machine learning Energy-efficient conversion Nano-catalysis
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Functional Surfactants for Molecular Fishing,Capsule Creation,and Single-Cell Gene Expression 认领 引用 被引量：7
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作者 Mohammad Suman Chowdhury Xingcai Zhang +5 位作者 Leila Amini Pradip Dey Abhishek Kumar Singh Abbas Faghani Michael Schmueck‑Henneresse Rainer Haag 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第9期377-385,共9页
Creating a single surfactant that is open to manipulation,while maintaining its surface activity,robustness,and compatibility,to expand the landscape of surfactant-dependent assays is extremely challenging.We report a... Creating a single surfactant that is open to manipulation,while maintaining its surface activity,robustness,and compatibility,to expand the landscape of surfactant-dependent assays is extremely challenging.We report an oxidation-responsive precursor with thioethers and multiple 1,2-diols for creating a variety of functional surfactants from one parent surfactant.Using these multifunctional surfactants,we stabilize microfluidics-generated aqueous droplets.The droplets encapsulate different components and immerse in a bioinert oil with distinct interfaces where an azide-bearing surfactant allow fishing of biomolecules from the droplets,aldehyde-bearing surfactant allow fabrication of microcapsules,and hydroxyl-bearing surfactants,with/without oxidized thioethers,allow monitoring of single-cell gene expression.Creating multifunctional surfactants poses opportunities for broad applications,including adsorption,bioanalytics,catalysis,formulations,coatings,and programmable subset of emulsions. 展开更多
关键词 Dendronized fluorosurfactants Droplet microfluidics Microcapsules Oxidation-responsive fluorosurfactants Cell encapsulation
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Large conversion of energy in dielectric elastomers by electromechanical phase transition 认领 引用 被引量：9
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作者 Tong-Qing Lu Zhi-Gang Suo 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2012年第4期1106-1114,共9页
When air is pumped in, a tubular balloon initially inflates slightly and homogeneously. A short section of the balloon then forms a bulge, which coexists with the unbulged section of the balloon. As more air is pumped... When air is pumped in, a tubular balloon initially inflates slightly and homogeneously. A short section of the balloon then forms a bulge, which coexists with the unbulged section of the balloon. As more air is pumped in, the bulged section elongates at the expense of the unbulged section, until the entire balloon is bulged. The phenomenon is analogous to the liquid-to-vapor phase transition. Here we study the bulging transition in a dielectric elastomer tube as air is pumped into the balloon and a voltage is applied through the thickness of the membrane. We formulate the condition for coexistent budged and unbulged sections, and identify allowable states set by electrical breakdown and mechanical rupture. We find that the bulging transition dramatically amplifies electromechanical energy conversion. Energy converted in an electromechanical cycle consisting of unbulged and bulged states is thousands of times that in an electromechanical cycle consisting of only unbulged states. 展开更多
关键词 Dielectric elastomer Bulge Electromechanical energy conversion. Tubular balloon Electromechanical transition
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MULTIAXIAL BEHAVIOR OF NANOPOROUS SINGLE CRYSTAL COPPER:A MOLECULAR DYNAMICS STUDY 认领 引用 被引量：3
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作者 Kejie Zhao Liangliang Fan Changqing Chen 《Acta Mechanica Solida Sinica》 SCIE EI 2009年第6期650-656,共7页
The stress-strain behavior and copper are studied by the molecular dynamics incipient yield surface of nanoporous single crystal （MD） method. The problem is modeled by a periodic unit cell subject to multi-axial loa... The stress-strain behavior and copper are studied by the molecular dynamics incipient yield surface of nanoporous single crystal （MD） method. The problem is modeled by a periodic unit cell subject to multi-axial loading. The loading induced defect evolution is explored. The incipient yield surfaces are found to be tension-compression asymmetric. For a given void volume fraction, apparent size effects in the yield surface are predicted： the smaller behaves stronger. The evolution pattern of defects （i.e., dislocation and stacking faults） is insensitive to the model size and void volume fraction. However, it is loading path dependent. Squared prismatic dislocation loops dominate the incipient yielding under hydrostatic tension while stacking-faults are the primary defects for hydrostatic compression and uniaxial tension/compression. 展开更多
关键词 molecular dynamics incipient yield surface size effect dislocations nanoporous single crystal copper
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